Abrégé

xy2z∞233 -33 2-33H-, and –Cl and optionally also substituted at least once by -COO-; where y is 1 to 3; and where z is 0 to 10.

Classes IPC  ?

• G01K 3/04 - Thermomètres donnant une indication autre que la valeur instantanée de la température fournissant des valeurs moyennesThermomètres donnant une indication autre que la valeur instantanée de la température fournissant des valeurs intégrées par rapport au temps
• C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• G01K 11/20 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des matériaux thermo-luminescents

Abrégé

The present invention relates to a redox flow battery comprising: a first compartment comprising a negolyte in the form of an aqueous composition comprising at least one compound of formula (I) The present invention relates to a redox flow battery comprising: a first compartment comprising a negolyte in the form of an aqueous composition comprising at least one compound of formula (I) and/or a salt of the compound of formula (I), and/or a reduced form of the compound of formula (I), wherein X1, X2, X3, X4, X5, X6, X7 and X8 are independently chosen from the group consisting of a hydrogen atom, a halogen, an ether group of formula —O-A, an OH group, COOH group, -A-COOH group, —O-A-COOH group and a linear, cyclic, or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, A representing a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising 1 to 10 carbon atoms, wherein at least one of X1, X2, X3, X4, X5, X6, X7 and X8 comprises an OH or COOH functional group; a second compartment comprising a posolyte in the form of an aqueous composition, comprising at least one electroactive molecule for example ferrocyanide ions [Fe(CN)6]4− and/or ferricyanide ions [Fe(CN)6]3−, the negolyte additionally comprising at least one solubilising base, the solubilising base being characterised in that the pKa of the conjugate acid of the solubilising base is higher than 9.5 in water at 25° C. and in that the volume of the cation of the solubilising base is between 14 and 650 cubic Angstroms.

Classes IPC  ?

• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

Method for operando characterization of the chemical composition of a battery cell, comprising the following steps: inserting an optical fiber made of chalcogenide glass through the battery cell, cycling the battery, while cycling the battery, generating an optical signal and transmitting it through the optical fiber, detecting, using an infrared spectrometer, the transmitted optical signal at an output extremity of the optical fiber, recording the detected optical signal over time, locating, using fiber evanescent wave spectroscopy, signature wavelengths for which the optical signal intensity is above a predetermined threshold within the spectrum, associating the located signature wavelengths to at least one predetermined chemical species.

Classes IPC  ?

• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
• G01N 21/3563 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solidesPréparation des échantillons à cet effet
• H01M 10/48 - Accumulateurs combinés à des dispositions pour mesurer, tester ou indiquer l'état des éléments, p. ex. le niveau ou la densité de l'électrolyte

Abrégé

Elementary cell for electrolysis, the elementary anode having a channel for bubbles of a first gas, the elementary cathode having a channel for bubbles of a second gas, wherein the elementary anode and/or the elementary cathode extend locally into the elementary main channel near the mouth, along a downstream portion of the mouth in an average direction of the elementary main channel.

Classes IPC  ?

• C25B 11/03 - ÉlectrodesLeur fabrication non prévue ailleurs caractérisées par la configuration ou la forme perforées ou foraminées
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 9/07 - Cellules sans séparation des produits
• C25B 9/13 - Cellules électrolytiques individuelles avec circulation d’un électrolyte

Abrégé

The invention relates to an antenna array system (1) comprising: a main powered antenna (30) which is configured to emit a beam directed in a plurality of main directions, the main powered antenna operating in a first frequency band; a set of parasitic antennas (10.1, 10.2, 10.3, 10.4) which are arranged so as to form a first envelope by concentrically surrounding the main powered antenna (30), each antenna comprising a substrate (13.1, 13.2, 13.3, 13.4) which is made of dielectric material, has a face oriented towards the outside of the envelope and provided with a parasitic radiating element (11.1, 11.2, 11.3, 11.4), and is provided with a ground plane, the parasitic radiating element (11.1, 11.2, 11.3, 11.4) being connected to the ground plane via a reactive load (12.1, 12.2, 12.3, 12.4), each parasitic antenna being configured to emit a beam directed in a main direction, the reactive loads (12.1, 12.2, 12.3, 12.4) being configured to selectively activate electromagnetic coupling between the main powered antenna and a pair of parasitic antennas in order to modify the directivity of the main powered antenna.

Classes IPC  ?

• H01Q 3/44 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier les caractéristiques électriques ou magnétiques des dispositifs de réflexion, de réfraction ou de diffraction associés à l'élément rayonnant
• H01Q 5/40 - Structures imbriquées ou entrelacéesDispositions combinées ou présentant un couplage électromagnétique, p. ex. comprenant plusieurs éléments rayonnants alimentés sans connexion commune
• H01Q 9/36 - Disposition verticale de l'élément avec charge au sommet
• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles

Abrégé

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

Classes IPC  ?

• C07D 209/56 - Systèmes cycliques contenant au moins trois cycles
• B01J 31/22 - Complexes organiques
• C07D 209/96 - Systèmes cycliques condensés en spiro
• C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
• C07F 7/18 - Composés comportant une ou plusieurs liaisons C—Si ainsi qu'une ou plusieurs liaisons C—O—Si
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique

Abrégé

The invention relates to a microwave sensor (2) for detecting at least one target gas, the sensor comprising: a substrate (4); a microwave device (5) printed on the substrate (4) and having a deposition opening (7); and a liquid substance (8) sensitive to the at least one target gas, the liquid substance (8) being arranged in the deposition opening (7) so as to be in contact with the microwave device (5), the liquid substance (8) being a deep eutectic solvent and chosen such that the presence of the at least one target gas causes at least one of a change in the dielectric characteristics or a change in the electrical characteristics of the liquid substance (8), resulting in a change in the distribution parameters of the microwave device (5).

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus

Abrégé

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

Classes IPC  ?

• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• C07C 69/608 - Esters d'acides carboxyliques avec un groupe carboxyle lié à un atome de carbone acyclique et comportant un cycle autre qu'un cycle aromatique à six chaînons dans la partie acide
• C07C 219/10 - Composés contenant des groupes amino et hydroxy estérifiés liés au même squelette carboné ayant des groupes hydroxy estérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé au moins un des groupes hydroxy étant estérifié par un acide carboxylique ayant le groupe carboxyle estérifiant lié à un atome de carbone acyclique d'un squelette carboné contenant des cycles
• C07D 249/04 - Triazoles-1, 2, 3Triazoles-1, 2, 3 hydrogénés
• C08G 65/00 - Composés macromoléculaires obtenus par des réactions créant une liaison éther dans la chaîne principale de la macromolécule

Abrégé

The inventors have succeeded in developing urea, amide or sulfonamide compounds, in particular urea compounds, bearing two side groups, one of which carries a dialkylaryl moiety, in particular a dialkylphenyl or dialkylpyridinyl moiety. These compounds have the advantage of inhibiting IRE1 RNase activity and sensitizing cancer cells, in particular GB cells, to chemotherapy. The present invention relates to urea, amide or sulfonamide compounds, in particular urea compounds, bearing two side groups, one of which carries a dialkylaryl moiety, in particular a dialkylphenyl or dialkylpyridinyl moiety, including their pharmaceutically acceptable salts and solvates which are useful as sensitizers for chemotherapy of cancer cells, particularly in glioblastoma, and are useful as therapeutic compounds, particularly in the treatment of cancers that may be treated by alkylating agents, such as temozolomide.

Classes IPC  ?

• C07D 215/06 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle comportant uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés à l'atome d'azote du cycle
• C07C 275/28 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné
• C07C 311/13 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant des cycles le squelette carboné contenant des cycles aromatiques à six chaînons
• C07D 215/227 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 2
• C07D 231/56 - BenzopyrazolesBenzopyrazoles hydrogénés
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 471/04 - Systèmes condensés en ortho
• A61P 35/00 - Agents anticancéreux
• A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
• A61K 31/145 - Amines, p. ex. amantadine ayant des atomes de soufre, p. ex. thiurames (N-C(S)-S-C(S)-N ou N-C(S)-S-S-C(S)-N)Sulfinylamines (-N=SO)Sulfonylamines (-N=SO2)
• A61K 31/407 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des systèmes hétérocycliques, p. ex. kétorolac, physostigmine

Abrégé

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is on position 3 and/or 5 of each indenyl, and wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater, as determined using 1H NMR; preferably wherein the aryl or heteroaryl substituent is on the 3-position of each indenyl; catalyst component B comprising a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is an unsubstituted or substituted aryl or heteroaryl; and wherein the unsubstituted or substituted aryl or heteroaryl is not on position 3 and/or 5 of the indenyl; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers.

Classes IPC  ?

• C08F 10/02 - Éthylène

Abrégé

A self-adaptive shielding device is suitable for a lens or a window of a piece of equipment provided with an electrically conductive enclosure containing an optical or RF sensor. The device includes a shielding screen having a switchable RF shielding mesh of micrometric pitch at least partially surrounded by a border of insulator-metal transition material arranged between the mesh and an electrically conductive envelope. A susceptor element is arranged facing the insulator-metal transition material and transforms incident electromagnetic energy (RFH) into activation heat for the insulator-metal transition material. The susceptor element causes a transition to the conductive state of the insulator-metal transition material under the action of the electromagnetic energy so as to electrically connect the mesh to the electrically conductive envelope when the incident electromagnetic energy exceeds a given threshold.

Classes IPC  ?

• H05K 9/00 - Blindage d'appareils ou de composants contre les champs électriques ou magnétiques

Abrégé

The present invention relates to a method for the electrosynthesis of substituted 1,4-naphthoquinones in an electrolytic cell, and to a method for the synthesis of substituted 1,4-naphthoquinones in a flow fuel cell. The present invention also relates to the use of said substituted 1,4-naphthoquinones as a redox molecule in the negolyte of a redox flow battery. Lastly, the present invention relates to a redox flow battery comprising a posolyte comprising a redox molecule and a negolyte comprising at least one substituted 1,4-naphthoquinone obtained by one of the methods according to the invention.

Classes IPC  ?

• C25B 3/07 - Composés contenant au moins un atome d’oxygène
• C25B 3/23 - Oxydation
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytesRégénération des électrolytes
• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
• C07C 46/00 - Préparation de quinones

Abrégé

The tumor microenvironment (TME) is characterized by hostile conditions that lead to the induction of the unfolded protein response (UPR) in both cancer cells and immune infiltrating cells. Mechanistically, DPM1 KO leads to reduced production of key cytokines and cell surface expression of PD-L1 (a major player in the control of adaptive immune response) through ERAD (ER-associated protein degradation). Additionally, DPM1 KO in cancer cells limited M2-like macrophages polarization overcoming immunosuppression and enhances cytotoxic T cell activity. Thus, the inventors' work reveals how tumoral UPR can limit tumor growth and suggests that DPM1 inhibition is a useful strategy for improving cancer immunotherapy. The present invention relates to a method of treating cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a Dolichol-phosphate mannosyltransferase (DPM1) inhibitor.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux
• A61K 38/00 - Préparations médicinales contenant des peptides
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being substituted with one or more substituents, wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater; catalyst component B comprising a bridged metallocene compound with a substituted or unsubstituted cyclopentadienyl group and a substituted or unsubstituted fluorenyl group; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers. The present invention also relates to a metallocene-catalyzed ethylene polymer having: a melt index MI2 ranging from 0.1 g/10 min to 12.0 g/10 min wherein MI2 is determined according to ISO 1133:2005 Method B, condition D, at a temperature 190° C. and a 2.16 kg load using a die of 2.096 mm; a molecular weight distribution Mw/Mn, ranging from 4.0 to 12.0, with Mw being the weight-average molecular weight and Mn being the number-average molecular weight; a rheology long chain branching index grheo of at least 0.90, preferably at least 0.93, preferably at least 0.95; and preferably at least 0.30% by weight of ethyl branching with regard to the total weight of the ethylene polymer measured by 13C NMR, with the proviso that said ethyl branching is not generated from 1-butene incorporation as comonomer.

Classes IPC  ?

• C08F 10/02 - Éthylène

Abrégé

A device for measuring a physical quantity related to an electromagnetic field emitted by an electromagnetic source. The device is configured to simulate the electromagnetic characteristics of a reference object made of a lossy medium, e.g. a biological tissue. The device includes: a dielectric layer including an upper surface faced to the electromagnetic source and a bottom surface, the dielectric layer being at least partly transparent to the electromagnetic field emitted by the electromagnetic source; an electromagnetic field enhancing element arranged relative to the dielectric layer and configured in a manner to enhance the intensity of the electromagnetic field transmitted through the dielectric layer in a pre-determined zone; and a sensor arranged beneath the electromagnetic field enhancing element and configured to measure the physical quantity related to the electromagnetic field transmitted through the dielectric layer and the electromagnetic field enhancing element.

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique

Abrégé

The present invention relates to a passive photoelectrochemical electrochemiluminescent device, systems and methods comprising a photovoltaic element and two electrodes.

Classes IPC  ?

• G01N 21/69 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité électriquement, p. ex. par électroluminescence spécialement adaptés pour les fluides
• G01N 21/76 - ChimioluminescenceBioluminescence
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• H01L 31/14 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails structurellement associés, p.ex. formés dans ou sur un substrat commun, avec une ou plusieurs sources lumineuses électriques, p.ex. avec des sources lumineuses électroluminescentes, et en outre électriquement ou optiquement couplés avec lesdites sour la ou les sources lumineuses étant commandées par le dispositif à semi-conducteur sensible au rayonnement, p.ex. convertisseurs d'images, amplificateurs d'images ou dispositifs de stockage d'image

Abrégé

The present invention relates to a process for the preparation of an optically pure (+) or (−) enantiomer of an iminium salt having the formula (I), aid process comprising the following steps: a) a reduction step of an iminium salt having the formula (II), said salt being in the form of a racemic mixture, in order to obtain a compound having the formula (III) in the form of a racemic mixture, b) a step of chiral HPLC separation of the compound of formula (III) in the form of a racemic mixture, for obtaining an optically pure (+) or (−) enantiomer compound having the formula (IV), and c) an oxidation step of the compound of formula (IV) for obtaining the compound of formula (I).

Classes IPC  ?

• C07D 207/20 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• B01J 31/22 - Complexes organiques
• C07D 471/08 - Systèmes pontés
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• H10K 85/30 - Composés de coordination

Abrégé

PIM2 kinase deregulation has been reported in several cancers. In particular, PIM2 is considered in multiple myeloma as part of the oncogenic process and several PIM kinase inhibitors have been developed showing encouraging results in preclinical studies and clinical trials. Now the inventors have developed an antisense RNA strategy based on a splice-switching oligonucleotide (SSO) so as to induce efficient knockdown of PIM2 expression. This SSO-mediated knockdown is a powerful approach to for cancer treatments. Accordingly, the present invention relates to the use of splice switching oligonucleotides for exon skipping-mediated knockdown of PIM2.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The invention relates to a device (1) which comprises an active electromechanical layer made of a semiconductor material (40), with two polymers, at least one of which is conjugated, arranged between two metal electrodes (2a, 2b) so as to be capable of generating a voltage between the two electrodes (2a, 2b) when the device is folded. The electromechanical layer (4) has a thickness of between 10 and 160 micrometres, at least one of the two electrodes (2a, 2b) being directly bonded to this layer. The electrodes are configured to be flexible and less thick than the active electromechanical layer within a multilayer structure of the device. The conductive polymer PEDOT may be one of the conjugated polymers. The flexoelectric device (1) obtained, protected if necessary in a protective assembly (7) by a flexible encapsulation material of submillimetric thickness, can be used in the form of a band in a sensor (C) for detecting a curvature or a position of an object.

Classes IPC  ?

• G01B 1/00 - Instruments de mesure caractérisés par l'usage d'un matériau spécifique
• G01B 7/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer les déformations dans un solide, p. ex. au moyen d'une jauge de contrainte à résistance
• G01L 1/00 - Mesure des forces ou des contraintes, en général
• H10N 30/30 - Dispositifs piézo-électriques ou électrostrictifs à entrée mécanique et sortie électrique, p. ex. fonctionnant comme générateurs ou comme capteurs
• H10N 30/077 - Formation de parties ou de corps piézo-électriques ou électrostrictifs sur un élément électrique ou sur un autre support par dépôt de couches piézo-électriques ou électrostrictives, p. ex. par impression par aérosol ou par sérigraphie par dépôt en phase liquide
• H10N 30/098 - Formation de matériaux organiques
• H10N 30/857 - Compositions macromoléculaires

Abrégé

Process for the hydrochlorination of alkenes, comprising the following steps: a)- preparing an organic solution A of a compound (I) comprising at least one alkene function by dissolving it potentially in an organic solvent; b)- mixing the solution A with a aqueous solution B comprising hydrochloric acid; c)- stirring the mixture comprising solution A and solution B at stirring speed of at least 500 rpm, and at a temperature in the range from -5 to 105°C for at least half an hour.

Classes IPC  ?

• C07C 17/08 - Préparation d'hydrocarbures halogénés par addition d'halogénures d'hydrogène à des hydrocarbures non saturés
• C07C 29/62 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par introduction d'atomes d'halogènePréparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 41/22 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par introduction d'atomes d'halogènePréparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 45/63 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par introduction d'atomes d'halogènePréparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par des réactions ne créant pas de groupe C=O par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 51/363 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par introduction d'atomes d'halogènePréparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 67/287 - Préparation d'esters d'acides carboxyliques par modification de la partie hydroxyle de l'ester sans introduction d'un groupe ester par introduction d'atomes d'halogènePréparation d'esters d'acides carboxyliques par modification de la partie hydroxyle de l'ester sans introduction d'un groupe ester par substitution d'atomes d'halogène par des atomes d'autres halogènes
• C07C 253/30 - Préparation de nitriles d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes cyano
• C07D 209/48 - Iso-indolesIso-indoles hydrogénés avec des atomes d'oxygène en positions 1 et 3, p. ex. phtalimide

Abrégé

The invention relates to a method for inhibiting the nitrification process in soil, wherein one or more miRNAs are applied to the soil in order to inhibit the expression of one or more genes participating in the nitrification process in said soil, such as the genes encoding the AMO (ammonia monooxygenase) enzyme and/or the HAO (hydroxylamine oxidoreductase) enzyme.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C05G 3/00 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais
• C05G 3/90 - Mélanges d'un ou plusieurs engrais avec des additifs n'ayant pas une activité spécifique d'engrais pour influer sur la nitrification des composés d’ammonium ou de l’urée dans le sol
• C05G 3/60 - Biocides ou conservateurs, p. ex. désinfectants, pesticides ou herbicidesProduits repoussant ou attirant les animaux nuisibles

Abrégé

Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide with an increasing incidence and limited therapeutic options. Therefore, there is an urgent need to open the field to new concepts for identifying clinically relevant therapeutic targets and biomarkers. Here, the inventors explored the role and the clinical relevance of circular RNA circLTBP2 in iCCA. In particular, CircLTBP2 (hsa_circ_0032603) was identified as a novel TGFβ-induced circRNA in several CCA cell lines. CircLTBP2 promotes tumor cell proliferation, migration and resistance to gemcitabine-induced apoptosis in vitro and tumor growth in vivo. Mechanistically, circLTBP2 acts as a competitive RNA regulating notably the activity of the tumor suppressor microRNA miR-338-3p, leading to the overexpression of its pro-metastatic targets. The restoration of miR-338-3p levels in iCCA cells reversed the pro-tumorigenic effects driven by circLTBP2, including the resistance to gemcitabine-induced apoptosis. In addition, circLTBP2 expression predicted a reduced survival, as detected in tumor tissues but also in serum exosomes isolated from patients with iCCA. In conclusion, CircLTBP2 is a novel effector of the pro-tumorigenic arm of TGFβ and a clinically relevant biomarker easily detected from liquid biopsies in iCCA. Thus, the present invention relates to the circulating RNA circLTBP2 as a biomarker and biotarget in intrahepatic cholangiocarcinomas.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention provides a method for depositing a film onto the surface of a complex three-dimensional substrate, while avoiding the fracturing and drawbacks observed in the prior art, resulting in a consistent deposition of the conductive film onto a substrate.

Classes IPC  ?

• B82Y 40/00 - Fabrication ou traitement des nanostructures
• H05K 3/20 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché par apposition d'un parcours conducteur préfabriqué
• H05K 3/22 - Traitement secondaire des circuits imprimés

Abrégé

CAMexpPP; - a pulsed light source (4) capable of generating light pulses that are intended to illuminate a measurement zone of the sample; - a synchronisation unit (5) configured to synchronise the emission of each light pulse with the exposure time of the camera according to a series of light pulses; - a unit for defining a series of light pulses (6) in order to define an increasing sequence of time intervals between two pulses; - an image construction unit (7) configured to construct a set of pairs of images in order to define an increasing sequence of time intervals between two images.

Classes IPC  ?

• H04N 23/74 - Circuits de compensation de la variation de luminosité dans la scène en influençant la luminosité de la scène à l'aide de moyens d'éclairage
• H04N 23/56 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande munis de moyens d'éclairage
• H04N 23/73 - Circuits de compensation de la variation de luminosité dans la scène en influençant le temps d'exposition
• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G02B 21/00 - Microscopes
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
• G01N 15/1434 - Dispositions optiques
• G01N 15/10 - Recherche de particules individuelles

Abrégé

Antenna includes at least one first resonant cavity and a second resonant cavity, each resonant cavity being closed by a base at one end and including a radiating element superimposed on the base of the resonant cavity, the radiating element of the first cavity being able to transmit a signal on a first frequency band and the radiating element of the second cavity being able to transmit a signal on a second frequency band separate from the first frequency band, characterized in that a first distance between the base and radiating element of the first cavity differs from a second distance between the base and radiating element of the second cavity.

Classes IPC  ?

• H01Q 5/30 - Dispositions permettant un fonctionnement sur différentes gammes d’ondes
• H01Q 1/28 - Adaptation pour l'utilisation dans ou sur les avions, les missiles, les satellites ou les ballons

Abrégé

The present invention pertains to a method for the prognosis or clear cell renal cell carcinoma (ccRCC) based on cell clusters identified by deconvolution of a single-cell malignancy atlas. The present inventors have designed and validated a scRNA-seq protocol to characterize the malignant cells (MC) in ccRCC tumors from ccRCC patients. By applying an in silico deconvolution approach 5 to a bulk RNA-seq dataset of ccRCCs, the present inventors have shown that the predicted proportion of specific cells clusters were strongly associated with specific prognoses and notably allow for the accurate stratification of patients. The markers identified by the present inventors particularly allow identifying high-grade patients who would have erroneously been classified as low- grade according to the current classification system.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

A dual-band analogue filter that is passing for IFF signals and ADS-B signals in a first and a second frequency band, and to reject signals received outside these bands, implemented using multi-planar technology, and comprising, in succession: a layer comprising an input port and an output port, a layer comprising a ground plane having openings facing the input port and the output port, a layer comprising N band-pass resonators, a layer comprising N band-stop resonators, arranged such that: the band-pass resonators are connected in pairs by coupling, the first and the last band-pass resonator are connected to the input port and the output port by electromagnetic coupling, each band-pass resonator is connected to a band-stop resonator by electromagnetic coupling.

Classes IPC  ?

• H04B 1/00 - Détails des systèmes de transmission, non couverts par l'un des groupes Détails des systèmes de transmission non caractérisés par le milieu utilisé pour la transmission
• H01P 1/203 - Filtres triplaque

Abrégé

The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1 and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention. an optional activator: an optional support: and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process. the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers: polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer. The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1 and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention. an optional activator: an optional support: and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process. the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers: polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer.

Classes IPC  ?

• C08F 4/76 - MétauxHydrures métalliquesComposés organiques de métalLeur utilisation comme précurseurs de catalyseurs choisis parmi les métaux non prévus dans le groupe choisis parmi les métaux réfractaires choisis parmi le titane, le zirconium, le hafnium, le vanadium, le niobium ou le tantale
• C08F 2/06 - Solvant organique
• C08F 210/06 - Propène

Abrégé

Wide-angle impedance-matching device (102) for a radiating-element array antenna, comprising:- a transmission screen (103) having a first surface intended to be positioned facing the radiating-element array parallel to the radiating aperture of the antenna and being configured to match the impedance of the antenna for an H-plane scan,- and a set of metal pins (104) placed orthogonally, on at least one surface of the transmission screen (103), at the intersection of at least some of the respective anti-symmetry planes of the electric field radiated by the antenna for an H-plane scan, for two linear polarizations in two orthogonal directions, said set of metal pins (104) being configured to match the impedance of the antenna for an E-plane scan.

Classes IPC  ?

• H01Q 1/38 - Forme structurale pour éléments rayonnants, p. ex. cône, spirale, parapluie formés par une couche conductrice sur un support isolant
• H01Q 9/04 - Antennes résonnantes
• H01Q 15/24 - Dispositifs polarisantsFiltres polarisants
• H01Q 21/06 - Réseaux d'unités d'antennes, de même polarisation, excitées individuellement et espacées entre elles
• H01Q 21/29 - Combinaisons d'unités d'antennes de types différents interagissant entre elles pour donner une caractéristique directionnelle désirée
• H03H 7/38 - Réseaux d'adaptation d'impédance

Abrégé

The present invention relates to an optically pure (+) or (−) enantiomer of a ruthenium complex having formula (I) as well as the preparation method of said enantiomer, and uses thereof as catalyst, in particular in asymmetric olefin metathesis.

Classes IPC  ?

• B01J 31/22 - Complexes organiques
• B01J 37/00 - Procédés de préparation des catalyseurs, en généralProcédés d'activation des catalyseurs, en général
• C07C 6/04 - Réactions de métathèse sur une liaison carbone-carbone non saturée sur une double liaison carbone-carbone
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique

Abrégé

A method of manufacturing a composite material including at least one ply integrating at least one electronic element situated at the surface of the ply. Also, materials obtained thereof and devices including such materials. The method includes: a) preparing or providing a first substrate having at least one layer; b) applying at least one electronic element onto a face of the first substrate; c) at least partially impregnating the so-obtained product within an impregnation material to form a matrix incorporating the at least one electronic element and the first substrate; d) preparing or providing an impregnable second substrate, the second substrate being placed on top of the impregnated at least one electronic element so that the at least one electronic element is interposed between the first substrate and the second substrate; e) removing the first substrate from the impregnated product obtained; and f) recovering the composite material.

Classes IPC  ?

• B29C 70/86 - Incorporation dans des couches de renforcement imprégnées cohérentes
• B29C 70/54 - Parties constitutives, détails ou accessoiresOpérations auxiliaires
• B29L 31/34 - Appareils électriques, p. ex. bougies ou leurs parties constitutives

Abrégé

The present invention relates to relates to a pharmaceutical composition comprising a combination of N-acetylcysteine with at least one inhibitor of regulated necrotic cell death, such as necroptosis and/or ferroptosis.

Classes IPC  ?

• A61K 31/16 - Amides, p. ex. acides hydroxamiques
• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61K 31/353 - 3,4-Dihydrobenzopyranes, p. ex. chromane, catéchine
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 17/18 - Antioxydants, p. ex. antiradicaux

Abrégé

The present invention relates to the use of a compound of formula (I) as a catalyst for the oxidation of an olefin into a ketone and to a process of oxidation of an olefin into a ketone comprising a step (a) of reacting said olefin with an oxidant in the presence of a catalyst of formula (I).

Classes IPC  ?

• C07C 45/36 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par oxydation avec l'oxygène moléculaire de restes —CHx dans des composés non saturés dans des composés contenant des cycles aromatiques à six chaînons
• C07C 49/76 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons
• B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine

Abrégé

The invention relates to the field of diagnosing steatohepatitis, in particular alcoholic steatohepatitis. By following studies on a cohort of nearly 200 patients, the inventors showed that four or five specific, readily available markers, when combined in a function, make it possible, by themselves, to highly accurately diagnose steatohepatitis at the early stages of the disease, when the subject is still asymptomatic. In particular, the invention relates to a non-invasive, highly performant method of diagnosing steatohepatitis in a subject, which combines in a function the values of the age, the blood concentration of cytokeratin 18 and at least two of: the body mass index, the blood concentration of α-2-macroglobulin and a data representative of liver stiffness as obtained by an ex vivo imaging technique. The method of the invention makes it possible to identify asymptomatic patients that may then benefit from potential therapeutics and/or be motivated to reduce alcohol consumption.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A device for controlling radiofrequency beams comprising a set of cells. Each cell comprises a support frame and an excitation element, and emits and/or receives beams in an invariant manner according to the direction of propagation of the beam. The frame is inscribed within a generally tubular shape, oriented along the axis Z of a reference frame, having a cross section of perimeter P, and comprises an entrance, an exit and a number N of slots between the exit and a position Zo located between the entrance and the exit. Each slot has a variable width along Z. The slot width has a minimum value at the position Zo, and a maximum value at the exit that is determined on the basis of the perimeter P and the number N.

Classes IPC  ?

• H01Q 13/08 - Terminaisons rayonnantes de lignes de transmission micro-ondes à deux conducteurs, p. ex. lignes coaxiales ou lignes micro-rayées
• H04B 7/06 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission

Abrégé

The invention proposes a device (10) for controlling radiofrequency beams comprising a set of cells (100). Each cell comprises a support frame (130) and an excitation element (150), and emits and/or receives beams in an invariant manner according to the direction of propagation of the beam. The frame is inscribed within a generally tubular shape, oriented along the axis Z of a reference frame (X,Y,Z), having a cross section of perimeter P, and comprises an entrance (131), an exit (132) and a number N of slots (133-n) between the exit and a position Zo located between the entrance and the exit. Each slot has a variable width along Z. The slot width has a minimum value at the position Zo, and a maximum value at the exit that is determined on the basis of the perimeter P and the number N.

Classes IPC  ?

• B33Y 10/00 - Procédés de fabrication additive
• H01Q 1/12 - SupportsMoyens de montage
• H01Q 1/36 - Forme structurale pour éléments rayonnants, p. ex. cône, spirale, parapluie
• H01Q 3/26 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la phase relative ou l’amplitude relative et l’énergie d’excitation entre plusieurs éléments rayonnants actifsDispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante
• H01Q 21/29 - Combinaisons d'unités d'antennes de types différents interagissant entre elles pour donner une caractéristique directionnelle désirée

Abrégé

A system for controlling the activation/deactivation of an electromagnetic shielding screen of a porthole or a protective window of an optoelectronic equipment, which includes, a radiofrequency electromagnetic sensor, with a bandwidth adapted to a cut-off band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, connected to a detector-rectifier with a sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured, in the presence of the electromagnetic field with a power exceeding said minimum value, to activate said device for activating/deactivating the electromagnetic shielding screen by capturing the electromagnetic energy supplied by said electromagnetic fields with a power exceeding said minimum value.

Classes IPC  ?

• G01J 1/02 - Photométrie, p. ex. posemètres photographiques Parties constitutives
• H05K 9/00 - Blindage d'appareils ou de composants contre les champs électriques ou magnétiques

Abrégé

A quasi-optical beamformer includes a plurality N> 1 of power feeds (PF), each of the i∈[1; N] power feeds (PF) being configured to emit a respective radio-frequency beam denoted Ri, a radio-frequency transmission line (LT) fed at a first end by the power feeds and comprising at a second end a plurality of network ports (PR) that are configured to collect radio-frequency radiation, the transmission line (LT) comprising a radio-frequency waveguide (GO) that comprises at least two metal plates (PM) that are stacked so as to guide the radio-frequency beams Ri, i∈[1; N] towards the network ports (PR), the transmission line (LT) extending along a central main axis denoted axis x, a first reflector (M1) having a first centre (C1) centred on the axis x and a first effective radius of curvature and being configured to reflect the guided radio-frequency beams Ri, i∈[1; N], a second reflector (M2) having a second effective radius of curvature and being configured to reflect the radio-frequency beams (RFi) reflected by the first reflector so as to direct them towards the network ports so as to form output radio-frequency beams (RSi), the first and second effective radii of curvature and an arrangement of the power feeds (PF) with respect to the first reflector being configured so that: each of the output radio-frequency beams (RSi) is a plane wave, and a transverse amplitude distribution Ai, on the network ports (PR), of each output radio-frequency beam (RSi), is substantially identical.

Classes IPC  ?

• H01Q 19/06 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des dispositifs de réfraction ou de diffraction, p. ex. lentilles
• H01Q 9/04 - Antennes résonnantes
• H01Q 23/00 - Antennes comportant des circuits ou des éléments de circuit actifs qui leur sont intégrés ou liés
• H04B 7/06 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission

Abrégé

FT{ΔTenppee(ω)) (5a, 5b, 5c) from said first Fourier transform

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique
• G01N 25/72 - Recherche de la présence de criques

Abrégé

Quasi-optical beamformer (1) comprising.-a plurality N > 1 of powei feeds (PF), each of the i c [1;N] power feeds (PF) being configured to emit a respective radio-frequency beam denoted Ri,- a radio-frequency transmission line (LT) fed at a first end by the power feeds and comprising at a second end a plurality of network ports (PR) that are configured to collect radio-frequency radiation, the transmission line (LT) comprising a radio-frequency waveguide (GO) that comprises at least two metal plates (PM) that are stacked so as to guide the radio-frequency beams Ri, i c [1; IV] towards the network ports (PR), the lransmission line (LT) extending along a cenlral main axis denoted axis x,- a first reflector (M1) having a first centre (C1) centred on the axis x and a first effective radius of curvature and being configured to reflect the guided radio-frequency beams Roi c [1; N],- a second reflector (M2) having a second effective radius of curvature and being configured to reflect the radio-frequency beams (RF) reflected by the first reflector so as to direct them towards the network ports so as to form output radio-frequency beams (RSi), the first and second effective radii of curvature and an arrangement of the power feeds (PF) with respect to the first reflector being configured so that- each of the output radio-frequency beams (RS,) is a plane wave, and- a transverse amplitude distribution Ai, on the network ports (PR), of each output radio-frequency beam (RS), is substantially identical

Classes IPC  ?

• H01Q 15/14 - Surfaces réfléchissantesStructures équivalentes
• H01Q 19/17 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des surfaces réfléchissantes où les surfaces sont concaves la source rayonnante primaire comprenant plusieurs éléments rayonnants
• H05K 1/02 - Circuits imprimés Détails

Abrégé

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis. The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61K 31/404 - Indoles, p. ex. pindolol
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61P 39/06 - Antiradicaux libres ou antioxydants
• C07D 209/12 - Radicaux substitués par des atomes d'oxygène

Abrégé

The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

Classes IPC  ?

• C07D 235/04 - BenzimidazolesBenzimidazoles hydrogénés
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a device and method for measuring an electromagnetic dosimetric quantity received by an object illuminated by an electromagnetic (EM) field (23) emitted by an electromagnetic source (2), comprising: - a screen (3) comprising a top surface (31) faced to the electromagnetic source (2) and a bottom surface (32) opposite to the top surface (31 ), said screen (3) being adapted to absorb at least a portion of the EM field emitted by the electromagnetic source (2); - the screen comprising a plurality unit cells (33); - at least one thermal sensor (5) arranged relative to the bottom surface of the screen (3) and configured to measure a physical quantity relative to the heat distribution along a surface of the screen induced due to the absorption of the electromagnetic field in the screen medium; - a processing unit (6) linked to the at least one thermal sensor (5) and configured to calculate the electromagnetic dosimetric quantities from the measured heat distribution, the information relative to the EM field emitted by the EM source, and the predetermined EM and thermal properties of the screen.

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique

Abrégé

The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.

Classes IPC  ?

• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
• B01L 9/00 - Dispositifs de supportDispositifs de serrage

Abrégé

Composite material comprising a ROMP-derived polyolefin embedded in a silicone matrix The present invention relates to a composite material comprising inclusions of a polyolefin obtainable by ring-opening metathesis polymerization of at least one cycloolefin, within a silicone matrix. It is also directed to a method for the preparation of this composite material and to the use of this composite material in the manufacture of various items.

Classes IPC  ?

• C08L 83/04 - Polysiloxanes
• C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle

Abrégé

The invention relates to the use of a ternary alloy having the formula SixTiyNiz, wherein x, y and z are natural numbers, for use in electrolysis and photoelectrolysis, in particular photo-oxidation of water. One aspect of the invention relates to a method for the manufacture of an electrode, the method comprising a step of heating a carrier comprising a surface having a layer of silicon on which a layer of TiO2 is disposed, the layer of TiO2 being covered with a layer of NiO; the heating step being carried out at a temperature above 1,000° C., and preferably between 1,150° C. and 1,250° C. The invention also relates to an electrode comprising a carrier, said electrode having either: an outer surface on which particles of a ternary alloy having the formula SixTiyNiz are positioned, wherein x, y and z are natural numbers, and wherein the particles form protrusions; or an outer surface consisting of a layer of said alloy, the layer comprising protrusions.

Classes IPC  ?

• C25B 11/089 - Alliages
• C25B 11/059 - Silicium
• C25B 11/087 - Composé photo-catalytique
• C23C 16/40 - Oxydes
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction

Abrégé

The invention relates to a sealed porous support comprising at least one surface, said surface being covered with a first layer comprising natural latex and a second layer comprising a natural or synthetic wax, the first layer being in contact with the at least one surface of the porous support, and the second layer being in contact with the natural or synthetic wax. The invention also relates to a method for obtaining such a support.

Classes IPC  ?

• D06M 15/693 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés macromoléculairesUn tel traitement combiné avec un traitement mécanique avec du caoutchouc naturel ou synthétique ou leurs dérivés
• D06N 3/18 - Cuir artificiel, toile cirée ou matériau similaire obtenu par enduction de nappes fibreuses avec une substance macromoléculaire, p. ex. avec des résines, du caoutchouc ou leurs dérivés ayant deux couches de substances macromoléculaires différentes
• D21H 19/12 - Couches sans pigments appliquées sous forme d'une solution utilisant de l'eau comme solvant unique, p. ex. en présence de composés acides ou alcalins
• D21H 19/18 - Couches sans pigments appliquées sous une forme autre que la solution aqueuse définie dans le groupe comprenant des cires
• D21H 19/82 - Papier comprenant plusieurs couches superposées
• C09D 107/00 - Compositions de revêtement à base de caoutchouc naturel
• C09D 191/06 - Cires
• D21H 27/10 - Papier d'emballage
• C08L 7/02 - Latex
• B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion
• B05D 7/22 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à des surfaces internes, p. ex. à l'intérieur de tubes
• B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers

Abrégé

The invention relates to a composition comprising natural latex and a natural or synthetic wax, the proportion of the natural latex to the natural or synthetic wax being 40:60 to 60:40 by weight. The invention also relates to the use of such a composition for sealing a surface.

Classes IPC  ?

• C08L 7/02 - Latex
• B32B 29/06 - Produits stratifiés composés essentiellement de papier ou de carton spécialement traité, p. ex. glacé, parcheminé
• B65D 65/40 - Emploi de stratifiés pour des buts particuliers d'emballage
• C08L 91/06 - Cires

Abrégé

The invention relates to a method for preparing a polyester polymer material, which comprises preparing a reaction medium comprising a mixture of at least one monomer chosen from ω-hydroxylated fatty acids and ω-hydroxylated fatty acid esters of an alcohol comprising an aliphatic chain comprising from 1 to 18 carbon atoms, and at least one phenolic compound, the total content of phenolic compound(s) being within a range of values from 0.3 to 42 mg equivalent of gallic acid per gram of the mixture. The method then comprises heating this reaction medium in order to carry out the polymerisation of the monomer and the phenolic compound and the cross-linking of the polymer thus formed.

Classes IPC  ?

• C08G 63/06 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés dérivés des acides hydroxycarboxyliques

Abrégé

The present invention belongs to the field of catalytic chemistry, and more specifically to catalysed oxidation of lignin. It also relates to synthesis of catalyst compounds. The present invention belongs to the field of catalytic chemistry, and more specifically to catalysed oxidation of lignin. It also relates to synthesis of catalyst compounds. The present invention relates to new acridinium-based photoredox catalyst compounds and their use thereof in a chemical reaction, preferably in depolymerisation of lignin models and ultimately lignin. The invention also relates to the method of synthesis of the new acridinium-based photoredox catalyst compounds according to the invention.

Classes IPC  ?

• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques
• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général
• B01J 37/34 - Irradiation ou application d'énergie électrique, magnétique ou ondulatoire, p. ex. d'ondes ultrasonores
• C07D 219/02 - Composés hétérocycliques contenant les systèmes cycliques de l'acridine ou de l'acridine hydrogénée avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du système cyclique

Abrégé

Disclosed is an absorbent structure which is a honeycomb structure extending between two end faces and which includes tubular cells, each cell having walls delimiting the cell, the walls extending between the two end faces, the walls being formed from a dielectric material, at least one cell having at least one strip of electrically conductive coating arranged in at least one wall or over a surface of at least one wall, the honeycomb structure being characterized by parameters chosen so that the absorbent structure provides an attenuation of at least 10 dB for each incident wave in a frequency range having a frequency spread greater than or equal to 15 GHz.

Classes IPC  ?

• H01Q 17/00 - Dispositifs pour absorber les ondes rayonnées par une antenneCombinaisons de tels dispositifs avec des éléments ou systèmes d'antennes actives

Abrégé

An active light-emitting layer composition including a thermally activated delayed fluorescence (TADF) molecule with TADF properties as a host material and a luminescent molecule with circularly polarized (CP) properties as a dopant. Also, a light-emitting device, such as an organic light-emitting diodes (OLED), including the active light-emitting layer made of this composition.

Classes IPC  ?

• H10K 85/60 - Composés organiques à faible poids moléculaire
• C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• C07C 255/51 - Nitriles d'acides carboxyliques ayant des groupes cyano liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné à des atomes de carbone de cycles aromatiques à six chaînons non condensés contenant au moins deux groupes cyano liés au squelette carboné
• C07D 213/06 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus de l'atome d'azote du cycle
• C07C 211/50 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné ayant des groupes amino liés à un seul cycle aromatique à six chaînons ayant au moins deux groupes amino liés au squelette carboné avec au moins deux groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné

Abrégé

The method of the invention comprises the steps of: obtaining a flexible temporary substrate made from a material capable of dissolving in a bath of liquid while remaining at the surface thereof and of returning to its initial state when dried after having been taken out of the bath; obtaining a former having at least one convex surface region capable of mating with at least one concave surface region; forming an electronic function on one face of the temporary substrate; placing the temporary substrate bearing the electronic function in the bath to form a film on the surface of the bath; transferring the electronic function and the film bearing same onto the at least one convex surface of the former; removing the former from the bath and drying same in order to cause the temporary substrate to return to its initial state; moulding the part on the former; removing the former to obtain the desired part covered with the temporary substrate, which can either be kept or removed.

Classes IPC  ?

• B29C 45/14 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet en incorporant des parties ou des couches préformées, p. ex. moulage par injection autour d'inserts ou sur des objets à recouvrir
• H05K 3/00 - Appareils ou procédés pour la fabrication de circuits imprimés

Abrégé

A device for controlling radiofrequency beams of a given polarization, the device includes a set of at least one cell, comprising a support frame and at least one interconnection internal to the frame. The frame is inscribed within a prism, having a given axis Z′ and faces connected to one another by edges oriented along the axis Z′. The frame comprises corner elements, each having a rim coincident with an edge and being arranged such that the frame has, on each face, a slot (440-n) extending along the axis Z′. The interconnection comprises inductive rods, each comprising two ends of which a first end is connected to a rim, the second ends being connected to one another at a connection point positioned in the centre of the frame in a plane orthogonal to the axis Z′. Each cell is configured to carry out polarization-invariant transmission and/or reflection of beams.

Classes IPC  ?

• H01Q 3/46 - Lentilles actives ou réseaux réfléchissants

Abrégé

What is proposed is a device (300) for controlling radiofrequency beams of a given polarization, the device comprising a set of at least one cell (400), comprising a support frame (420) and at least one interconnection (460) internal to the frame. The frame is inscribed within a prism, having a given axis Z' and Ar faces connected to one another by Ar edges oriented along the axis Z'. The frame comprises Ar corner elements, each having a rim coincident with an edge and being arranged such that the frame has, on each face, a slot (440-n) extending along the axis Z'. The interconnection comprises Ar inductive rods (462-n), each comprising two ends of which a first end is connected to a rim, the second ends being connected to one another at a connection point positioned in the centre of the frame in a plane orthogonal to the axis Z'. Each cell is configured to carry out polarization-invariant transmission and/or reflection of beams.

Classes IPC  ?

• H01Q 15/10 - Dispositifs de réfraction ou diffraction, p. ex. lentille, prisme concernant un réseau de discontinuité d'impédance tridimensionnel, p. ex. trous dans une surface conductrice ou disques conducteurs formant diélectrique artificiel

Abrégé

An optically transparent electromagnetic shielding assembly exhibiting a shielding efficiency that is increased when a conducting or polarizable fluid produces a low electrical impedance value between a periphery and a central region of a window. Such shielding assembly is useful in detection systems that are exposed to varying intensities of electromagnetic radiation, such as microwave radiation.

Classes IPC  ?

• H01L 31/0203 - Conteneurs; Encapsulations
• H01L 23/552 - Protection contre les radiations, p. ex. la lumière
• H01L 25/16 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant de types couverts par plusieurs des sous-classes , , , , ou , p. ex. circuit hybrides

Abrégé

CD95L is a transmembrane glycoprotein that acts through cell contact. After cleavage by metalloproteases, a soluble CD95L (cleaved CD95L or cl-CD95L) is released into the bloodstream. This soluble ligand contributes to aggravate chronic inflammatory disorders such as systemic lupus erythematosus (SLE) and may exert pro-oncogenic functions by promoting the survival of ovarian and breast cancers and chemotherapy resistance of lung cancers. The inventors hypothesized that monoclonal antibodies targeting the Metalloprotease-Cleavage Sites of CD95L (MCSCs) encompassing amino-acid residues 103 to 145 could prevent the access to metalloproteases and inhibit CD95L shedding. Therefore, they generated antibodies covering different epitopes within MCSC and two of them (i.e., 3C7 and 9F5), efficiently abrogated the cleavage of CD95L by MMP2 and MMP3. The results indicate that these MCSC- targeting mAbs can compete with MMPs and represent original and attractive therapeutic options to block the release of the inflammatory s-CD95L.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 35/00 - Agents anticancéreux

Abrégé

A multilayer waveguide structure (2) for a radiofrequency antenna comprises: - a stack of substrates (4) separated by each other by interface layers (10), the substrates having a permittivity larger or equal to 1, and - metal vias (12) or metal trenches formed in at least some of the substrates. Each interface layer (10) comprises a first metal layer (16), a second metal layer (18), and an adhesive layer (14) between the first metal layer (16) and the second metal layer (18). At least one of said interface layer (10) comprises patterned structures (R12), for which the adhesive layer (14) is thinner while still preventing a direct electric contact between the first and second metal layers (16, 18), and each said patterned structure (R12) is located near or at the base or the top of a metal via (12) or metal trench.

Classes IPC  ?

• H01P 5/02 - Dispositifs de couplage du type guide d'ondes à coefficient de couplage invariable
• H05K 3/46 - Fabrication de circuits multi-couches
• H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
• H01P 5/12 - Dispositifs de couplage présentant au moins trois accès

Abrégé

A multilayer waveguide structure (2) for a radiofrequency antenna comprises: - a stack of substrates (4) separated by each other by interface layers (10), the substrates having a permittivity larger or equal to 1, and - metal vias (12) or metal trenches formed in at least some of the substrates. Each interface layer (10) comprises a first metal layer (16), a second metal layer (18), and an adhesive layer (14) between the first metal layer (16) and the second metal layer (18). At least one of said interface layer (10) comprises patterned structures (R12), for which the adhesive layer (14) is thinner while still preventing a direct electric contact between the first and second metal layers (16, 18), and each said patterned structure (R12) is located near or at the base or the top of a metal via (12) or metal trench.

Classes IPC  ?

• H01P 5/02 - Dispositifs de couplage du type guide d'ondes à coefficient de couplage invariable
• H01P 5/12 - Dispositifs de couplage présentant au moins trois accès
• H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
• H05K 3/46 - Fabrication de circuits multi-couches

Abrégé

The present invention relates to compounds simultaneously having thermally activated delayed fluorescence (TADF), circularly polarised luminescence (CPL) and aggregation-induced emission enhancement (AIEE) properties. The invention also relates to the use of such compounds as a photocatalyst or as a dopant, in particular in the emitting layers of light-emitting diodes (OLEDs), as well as light-emitting devices or light-emitting diodes (OLEDs) comprising such compounds.

Classes IPC  ?

• H10K 85/60 - Composés organiques à faible poids moléculaire
• C07D 491/22 - Composés hétérocycliques contenant dans le système cyclique condensé, à la fois un ou plusieurs cycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, et un ou plusieurs cycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus dans les groupes , , ou dans lesquels le système condensé contient au moins quatre hétérocycles
• H10K 50/11 - OLED ou diodes électroluminescentes polymères [PLED] caractérisées par les couches électroluminescentes [EL]

Abrégé

The present invention relates to a redox flow battery, comprising: - a first compartment comprising a negolyte, in the form of an aqueous composition, comprising at least one compound of formula (I) and/or a salt of the compound of formula (I), and/or a reduced form of the compound of formula (I), wherein X1, X2, X3, X4, X5, X6, X7and X8are independently selected from the group consisting of a hydrogen atom, a halogen, an ether group of formula -O-A, an OH group, a COOH group, an -A-COOH group, an -O-A-COOH group and a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, A representing a linear, cyclic or branched, saturated or unsaturated hydrocarbon group comprising from 1 to 10 carbon atoms, wherein at least one of X1, X2, X3, X4, X5, X6, X7and X866]4-66]3-, the negolyte additionally comprising at least one solubilising base, the solubilising base being characterised in that the pKa of the conjugate acid of the solubilising base is higher than 9.5 in water at 25°C and in that the volume of the cation of the solubilising base is between 14 and 650 cubic Angstroms.

Classes IPC  ?

• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
• C08K 5/13 - PhénolsPhénolates

Abrégé

The inventors have succeeded in developing urea, oxalamide, amide, thiourea, carbamate or ester compounds, in particular urea compounds, bearing two side groups, one of which carries a hydroxyphenyl or phenyl moiety, in particular a hydroxyphenyl moiety. These compounds have the advantage of inhibiting IRE1 RNase activity and sensitizing cancer cells, in particular GB cells, to chemotherapy. The present invention relates to urea, oxalamide, amide, thiourea, carbamate or ester compounds, in particular urea compounds containing a hydroxyphenyl or phenyl moiety, in particular a hydroxyphenyl moiety, including their pharmaceutically acceptable salts and solvates which are useful as sensitizers for chemotherapy of cancer cells, particularly in glioblastoma, and are useful as therapeutic compounds, particularly in the treatment of cancers that may be treated by alkylating agents, such as temozolomide.

Classes IPC  ?

• C07D 215/38 - Atomes d'azote
• C07D 277/82 - Atomes d'azote
• C07C 275/00 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 31/428 - Thiazoles condensés avec des carbocycles
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to the use of a hydroperoxy alcohol-type compound, or a 1,2,4-trioxane compound thereof, as an antimicrobial agent, making it possible for it to be used in various applications and in particular as a preservative and/or to improve the antimicrobial properties of at least one preservative, to modulate the skin microbiota, in the treatment or prevention of diseases affecting the skin, the mucous membrane and/or skin appendages or even to cleanse, sanitise, disinfect and/or sterilise a surface other than the skin, skin appendages and mucous membranes, in particular a hard surface or a textile. It also relates to a composition comprising such a compound. In addition to its antimicrobial properties, the aforementioned compound has good safety and emollient properties, making it particularly suitable for cosmetic use.

Classes IPC  ?

• A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
• A61K 31/327 - Composés peroxy, p. ex. hydroperoxydes, peroxydes, peroxyacides
• A61Q 5/00 - Préparations pour les soins des cheveux
• A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61Q 5/02 - Préparations pour le lavage des cheveux
• A61Q 19/10 - Préparations pour le nettoyage ou le bain
• A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

The present invention provides inhibitory peptides for use in the diagnostic and/or treatment of tauopathies, in particular Alzheimer's Disease and Pick's Disease. The inhibitory peptides comprise a hexapeptide sequence that specifically inhibits interactions of the PHF6 sequence within pathological Tau protein.

Classes IPC  ?

• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

2wnww being the weight- average molecular weight and Mn being the number-average molecular weight; a rheology long chain branching index grheo of at least 0.90, preferably at least 0.93, preferably at least 0.95; and preferably at least 0.30 % by weight of ethyl branching with regard to the total weight of the ethylene polymer measured by 13C NMR, with the proviso that said ethyl branching is not generated from 1 -butene incorporation as comonomer.

Classes IPC  ?

• C08F 210/16 - Copolymères de l'éthylène avec des alpha-alcènes, p. ex. caoutchoucs EP
• C07F 17/00 - Metallocènes
• C08F 4/659 - Composant couvert par le groupe contenant une liaison métal de transition-carbone
• C07F 7/00 - Composés contenant des éléments des groupes 4 ou 14 du tableau périodique

Abrégé

The present invention relates to a catalyst composition comprising: catalyst component A comprising the meso form of a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is on position 3 and/or 5 of each indenyl, and wherein at least one of the substituents is an aryl or heteroaryl; wherein the meso/rac ratio of the meso form of the bridged metallocene compound of catalyst component A is 95:5 or greater, as determined using 1H NMR; preferably wherein the aryl or heteroaryl substituent is on the 3- position of each indenyl; catalyst component B comprising a bridged metallocene compound with two indenyl groups, each indenyl being independently substituted with one or more substituents, wherein at least one of the substituents is an unsubstituted or substituted aryl or heteroaryl; and wherein the unsubstituted or substituted aryl or heteroaryl is not on position 3 and/or 5 of the indenyl; and an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to a polymerization process using said composition. The invention further relates to olefin polymers at least partially catalyzed by said catalyst composition and articles comprising said olefin polymers.

Classes IPC  ?

• C08F 210/16 - Copolymères de l'éthylène avec des alpha-alcènes, p. ex. caoutchoucs EP
• C08F 4/659 - Composant couvert par le groupe contenant une liaison métal de transition-carbone

Abrégé

The present invention provides inhibitory peptides for use in the diagnostic and/or treatment of tauopathies, in particular Alzheimer's Disease and Pick's Disease. The inhibitory peptides comprise a hexapeptide sequence that specifically inhibits interactions of the PHF6 sequence within pathological Tau protein.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Chronic inflammatory diseases are becoming a leading cause of death throughout the world. Although such diseases appear to be clinically different, they share many similarities in terms of genetic background and pathophysiological pathways. There is an interest to develop drugs for inhibiting the CD95 -mediated non-apoptotic signaling pathway that contributes to inflammation. In particular, neutralizing anti-CD95L monoclonal antibodies are highly desirable. The inventors a neutralizing anti-CD95L monoclonal antibody (mAb), designated JQ3 (IgGl K). In particular, the neutralizing effect of JQ3 was confirmed since this home-made monoclonal antibody inhibited the CD95-mediated apoptotic signaling pathway induced in T- cell line Jurkat more efficiently than NOK-1 mAb. Interestingly, JQ3 blocked the CD95- mediated Ca2+ response in neutrophils exposed to sera from various inflammatory conditions (COVID19 patients and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients). The present invention thus relates to neutralizing anti-CD95L monoclonal antibodies that revie from JQ3.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61P 35/00 - Agents anticancéreux
• A61P 37/02 - Immunomodulateurs

Abrégé

An isolated monoclonal antibody against the interleukin 1-alpha or beta receptor antagonist, known as IL-1RA. The antibody inhibits the interaction of IL-1RA with the membrane-binding chain thereof, the interleukin-1 receptor. Also, nucleic acid molecule encoding for a light chain of the monoclonal antibody, and a nucleic acid molecule encoding for a heavy chain of the monoclonal antibody. Also, a method for treating an inflammatory, infectious or autoimmune disease, which includes administering the isolated monoclonal antibody or a nucleic acid coding for the isolated monoclonal antibody, and a method of or the diagnosis of an inflammatory, infectious or autoimmune diseases, which includes contacting a biological sample with the isolated monoclonal antibody.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61P 31/04 - Agents antibactériens

Abrégé

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): (I) (II) as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

Classes IPC  ?

• C07D 209/58 - Systèmes cycliques contenant au moins trois cycles condensés en [b] ou en [c]

Abrégé

A technique and device for managing blocks of commands intended for a microscopy imaging device configured to acquire images of a sample. Each block of commands includes driving commands serving to drive a plurality of functional modules of the imaging device. Each command is defined by at least one acquisition parameter. The technique includes executing a first, predefined block of commands to acquire first images, and upon positive verification, by image analysis of a stop condition upon executing the first block, stopping the first block to execute a second predefined block of commands to acquire second images, the commands of the second block being defined by at least one second acquisition parameter, dynamically defined depending on the image analysis.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

The present invention relates to an iminium salt having the following formula (I) and also to a ruthenium complex having the following formula (II): (I) (II) as well as the use of said ruthenium complex as catalyst, in particular in olefin metathesis.

Classes IPC  ?

• C07D 209/58 - Systèmes cycliques contenant au moins trois cycles condensés en [b] ou en [c]
• B01J 31/00 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique

Abrégé

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

Classes IPC  ?

• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament
• C07C 31/27 - Alcools polyhydroxyliques contenant des cycles saturés
• C07C 55/26 - Composés saturés comportant plusieurs groupes carboxyle liés à des atomes de carbone acycliques contenant des cycles
• C07C 69/60 - Esters d'acide maléiqueEsters d'acide fumarique
• C07C 69/608 - Esters d'acides carboxyliques avec un groupe carboxyle lié à un atome de carbone acyclique et comportant un cycle autre qu'un cycle aromatique à six chaînons dans la partie acide
• C07C 219/10 - Composés contenant des groupes amino et hydroxy estérifiés liés au même squelette carboné ayant des groupes hydroxy estérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé au moins un des groupes hydroxy étant estérifié par un acide carboxylique ayant le groupe carboxyle estérifiant lié à un atome de carbone acyclique d'un squelette carboné contenant des cycles
• C07D 249/04 - Triazoles-1, 2, 3Triazoles-1, 2, 3 hydrogénés

Abrégé

The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric acid (CFTA) lipids, for drug delivery applications.

Classes IPC  ?

• C07C 31/27 - Alcools polyhydroxyliques contenant des cycles saturés
• C07C 55/26 - Composés saturés comportant plusieurs groupes carboxyle liés à des atomes de carbone acycliques contenant des cycles
• C07C 69/60 - Esters d'acide maléiqueEsters d'acide fumarique
• C07D 249/04 - Triazoles-1, 2, 3Triazoles-1, 2, 3 hydrogénés
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• C07C 219/10 - Composés contenant des groupes amino et hydroxy estérifiés liés au même squelette carboné ayant des groupes hydroxy estérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé au moins un des groupes hydroxy étant estérifié par un acide carboxylique ayant le groupe carboxyle estérifiant lié à un atome de carbone acyclique d'un squelette carboné contenant des cycles
• C07C 69/608 - Esters d'acides carboxyliques avec un groupe carboxyle lié à un atome de carbone acyclique et comportant un cycle autre qu'un cycle aromatique à six chaînons dans la partie acide

Abrégé

The invention relates to a self-adaptive shielding device for a lens or a window (1) of a piece of equipment provided with an electrically conductive enclosure (10) enclosing an optical or RF sensor (20) behind said lens or said window, said device comprising, on at least one face of said lens or said window, a shielding screen comprising a switchable RF shielding mesh (2) with a micrometric pitch at least partially surrounded by an edge of metal-insulator transition material (3) arranged between said mesh and an electrically conductive envelope (11) for shielding said equipment, comprising a susceptor element (5) arranged opposite or in contact with said metal-insulator transition material and suitable for transforming incident electromagnetic energy (RFH) into an amount of heat for activating said metal-insulator transition material (3, 3a, 31), said susceptor element being dimensioned to cause a transition to the conductive state of said metal-insulator transition material (3, 3a, 31, 31a) by means of said electromagnetic energy so as to electrically connect said mesh to said electrically conductive envelope when the incident electromagnetic energy exceeds a given threshold.

Classes IPC  ?

• G02B 26/00 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables
• H05K 9/00 - Blindage d'appareils ou de composants contre les champs électriques ou magnétiques
• G01J 5/06 - Dispositions pour éliminer les effets des radiations perturbatricesDispositions pour compenser les changements de la sensibilité

Abrégé

A device (1) for measuring a physical quantity related to an electromagnetic (EM) field emitted by an electromagnetic source (2), the device configured to simulate the EM characteristics of a reference object made of a lossy medium, e.g. a biological tissue, particularly a human tissue, comprising: - at least one dielectric layer (3) comprising an upper surface faced (31) to the electromagnetic source (2) and a bottom surface (32), said dielectric layer (3) being at least partly transparent to the EM field emitted by the electromagnetic source (2); - at least one electromagnetic field enhancing element (4) arranged relative to the at least one dielectric layer (3) and configured in a manner to enhance the intensity of the electromagnetic field transmitted through the at least one dielectric layer (3) in a predetermined zone (12); - at least one sensor (5) arranged beneath the at least one electromagnetic field enhancing element (4) and configured to measure said physical quantity related to the electromagnetic field transmitted through the at least one dielectric layer (3) and the at least one electromagnetic field enhancing element (4).

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique
• H04B 17/00 - SurveillanceTests
• G09B 23/30 - Modèles anatomiques
• H04M 1/24 - Dispositions pour les tests

Abrégé

A device (1) for measuring a physical quantity related to an electromagnetic (EM) field emitted by an electromagnetic source (2), the device configured to simulate at least one EM scattering characteristic of a reference object made of an EM lossy medium, in particular a biological tissue, comprising: - at least one dielectric layer (3) comprising a top surface (31) oriented to the electromagnetic source (2) and a bottom surface (32), said layer (3) being at least partly transparent to the EM field emitted by the electromagnetic source (2); - at least one aperture focusing element (4) attached to or at least partly embedded in the bottom surface (32) of the dielectric layer (3), said at least one aperture focusing element (4) configured to focus the EM field incident on the at least one aperture element (4) into a focal zone (9); - at least one sensor (5) arranged beneath the at least one aperture focusing element (4) and configured to measure the physical quantity related to the electromagnetic field transmitted through the at least one dielectric layer (3) and the aperture focusing element (4), said at least one sensor (5) being positioned in the focal zone (9).

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique
• G09B 23/30 - Modèles anatomiques
• H04B 17/00 - SurveillanceTests
• H04M 1/24 - Dispositions pour les tests

Abrégé

The present invention relates to the treatment of diseases induced by Enterobacteriae. The inventors evaluated, in a multicellular in vitro model associating cells representing human enterocytes (Caco-2 cells), goblet mucus secreting cells (HT29-MTX) and M cells, whether Bacteroides fragilis, a non-enterotoxigenic strain, could be useful to limit the severity of the Salmonella Heidelberg infection, with an hypermutator phenotype, by analyzing their impact on growth and mucosal translocation. Thus, the present invention relates to a Bacteroides fragilis strain for use in the treatment of diseases induced by Enterobacteriae in a subject in need thereof.

Classes IPC  ?

• A61K 35/741 - Probiotiques
• A61P 31/04 - Agents antibactériens

Abrégé

111.

Classes IPC  ?

• G01R 29/08 - Mesure des caractéristiques du champ électromagnétique
• G09B 23/30 - Modèles anatomiques
• H04B 17/00 - SurveillanceTests
• H04M 1/24 - Dispositions pour les tests

Abrégé

This method for predicting frailty of a subject, using a wearable device, comprising an accelerometer, worn in unsupervised conditions, comprising: •computing (58) a plurality of global features representative of the acceleration signals captured during a predetermined observation period, •extracting (60) segments of acceleration signals within at least one period of walking of the subject within the observation period and computing (62) a plurality of local features representative of the subject's gait, •applying a first frailty assessment module (64) on the plurality of global features to obtain a first output representative of the frailty of the subject, •applying a second frailty assessment module (66) on the plurality of local features to obtain a second output representative of the frailty of the subject, •combining (68) the first and second outputs (64, 66) to predict a status of frailty of the subject amongst the classes {robust, pre-frail, frail} for the predetermined observation period.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

A sensor for detecting a volatile compound or gas. The sensor includes a transducer having: a planar resonator including a plurality of metal tracks, on a printed circuit, of the coplanar type; and a sensitive layer deposited on a predetermined portion of the resonator. The sensitive layer is configured so that the presence of a volatile compound or of a gas to be detected implies a modification of the permittivity of the sensitive layer resulting in a modification of the features of the sensor during its electrical power supply.

Classes IPC  ?

• G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

The invention relates to a device (1) for determining polarimetric information, comprising: - an excitation source (2) suitable for exciting a measurement point (31) of a sample (3) in order to cause a luminescent beam to be emitted by the measurement point; - an optical collection system (5) configured to collect the luminescence signal; - a rotary analyser (7) configured to modulate the intensity of the luminescent beam on the basis of the polarisation angle of the rotary analyser; - a detector (9) able to acquire a signal of the intensity of the modulated luminescent beam; - a synchronisation unit (11) configured to synchronise the acquisition of the signal by the detector (9) and the rotation of the rotary analyser (7) such that the signal acquisition frequency is a multiple of the rotational frequency of the analyser (7); - a data processing unit (20) configured to determine at least one piece of polarimetric information contained in the signal of the luminescent beam.

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

The invention relates to a supramolecular nanotube comprising at least one single-chain magnet including a coordination polymer, said coordination polymer comprising at least one linear macromolecular chain comprising repeating units containing at least one metal, said metal being coordinated by at least one ligand comprising at least one linear carbon chain, said linear carbon chain comprising more than 5 carbons, preferably the linear carbon chain comprises 6 to 30 carbons.

Classes IPC  ?

• C08L 101/12 - Compositions contenant des composés macromoléculaires non spécifiés caractérisées par des propriétés physiques, p. ex. anisotropie, viscosité ou conductivité électrique
• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron

Abrégé

An antenna (100) comprising at least a first resonant cavity (110) and a second resonant cavity (120), each resonant cavity (110, 120) being closed off by a base (112, 122) at one end and comprising a radiating element (111, 121) superimposed on the base of the resonant cavity, the radiating element (111) of the first cavity (110) being able to emit a signal in a first frequency band and the radiating element (121) of the second cavity (120) being able to emit a signal in a second frequency band separate from the first frequency band, characterized in that a first distance between the base (112) and the radiating element (111) of the first cavity (110) is different from a second distance between the base (122) and the radiating element (121) of the second cavity (120).

Classes IPC  ?

• H01Q 1/28 - Adaptation pour l'utilisation dans ou sur les avions, les missiles, les satellites ou les ballons
• H01Q 5/48 - Combinaisons de plusieurs antennes de type dipôle
• H01Q 19/10 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des surfaces réfléchissantes
• H01Q 21/26 - Antennes tourniquet ou similaires comportant des dispositions de trois éléments ou plus allongés disposés radialement et symétriquement dans un plan horizontal par rapport à un centre commun

Abrégé

The present invention relates to a process for the preparation of an optically pure (+) or (-) enantiomer of an iminium salt having the formula (I), aid process comprising the following steps: • a) a reduction step of an iminium salt having the formula (II), said salt being in the form of a racemic mixture, in order to obtain a compound having the formula (III) in the form of a racemic mixture, • b) a step of chiral HPLC separation of the compound of formula (III) in the form of a racemic mixture, for obtaining an optically pure (+) or (-) enantiomer compound having the formula (IV), and • c) an oxidation step of the compound of formula (IV) for obtaining the compound of formula (I).

Classes IPC  ?

• C07D 207/20 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• C07D 471/08 - Systèmes pontés
• B01J 31/22 - Complexes organiques
• C07C 6/02 - Réactions de métathèse sur une liaison carbone-carbone non saturée

Abrégé

The present invention relates to a process for preparing hydroperoxy alcohols using hydrogen peroxide as an oxidant in a solvent selected from water-soluble carboxylic acids, in the presence of a metallic mixed oxide heterogeneous catalyst. It also pertains to the use of this catalyst in the synthesis of hydroperoxy alcohols.

Classes IPC  ?

• C07C 409/02 - Composés peroxy le groupe —O—O— étant lié à un atome de carbone, qui n'est pas substitué de plus par des atomes d'oxygène, et à un atome d'hydrogène, c.-à-d. hydroperoxydes
• B01J 23/00 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe

Abrégé

Method for operando characterization of the chemical composition of a battery cell (12), comprising the following steps: - inserting an optical fiber (14) made of chalcogenide glass through the battery cell (12), - cycling the battery (12), - while cycling the battery (12), generating an optical signal and transmitting it through the optical fiber (14), - detecting, using an infrared spectrometer (20), the transmitted optical signal at an output extremity (14O) of the optical fiber (14), - recording the detected optical signal over time, - locating, using fiber evanescent wave spectroscopy, signature wavelengths for which the optical signal intensity is above a predetermined threshold within the spectrum, - associating said located signature wavelengths to at least one predetermined chemical species.

Classes IPC  ?

• G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
• G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
• G01N 21/552 - Réflexion totale atténuée
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé

Abrégé

The invention relates to a vial (100) for the cryopreservation of multiple biological samples. This vial (100) comprises: a container (110), made in one piece, defining an inner volume (112) and an opening provided with a thread (132); and a threaded cap (150), which cooperates with the thread (132) of the opening so as to selectively close the inner volume (112), in a sealed configuration of the vial (100), or allow the access to the inner volume (112), in an unsealed configuration of the vial (100). According to the invention, the container (110) includes at least one inner partition (124), configured to divide the inner volume (112) in at least two separated chambers (126), each chamber (126) being accessible from the opening (114). Each chamber is configured to receive one biological sample. The vial according to the invention is easy to handle and space-saving. Also disclosed is a mounting base comprising at least one recessed reception volume that is configured to receive such a vial.

Classes IPC  ?

• A01N 1/02 - Conservation de parties vivantes
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01L 9/06 - Supports de tubes à essaiPorte-tubes à essai
• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique

Abrégé

A method of obtaining 3D cell structures including differentiated human hepatic cells. The method includes: a first step of culturing stem cell-derived or immortalized human hepatic progenitors in a non-adherent culture vessel, preferably a low or ultra-low attachment culture vessel; a second step of transferring the stem cell-derived or immortalized human hepatic progenitors to a culture medium including methacrylated gelatin (GelMa), thereby embedding the stem cell-derived or immortalized human hepatic progenitors in a GelMa matrix; and a third step of covering the GelMa matrix with culture medium and culturing the stem cell-derived or immortalized human hepatic progenitors embedded in the GelMa matrix, thereby obtaining 3D cell structures including differentiated human hepatic cells. Also, methods for engineering an artificial liver model or an artificial liver organ, and for assessing in vitro the metabolism, toxicity and/or therapeutic effects of a compound.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

A device for locating target points on a magnetic resonance image of the brain of a subject includes a trained neural network configured to receive as input a 3D MR image of the brain of a subject, and to output the location, on the image, of at least one determined brain target point. The neural network includes a plurality of processing stages. Each processing stage processes an image at a respective resolution, and the processing stage of lowest resolution outputs an estimate of the location of each target point. Each other processing stage is configured to receive, from a lower resolution processing stage, an estimate of the locations of the target points, crop the input image to a smaller region surrounding each estimated target point, determine an updated estimate of the location of each target point, and provide the updated estimation to the processing stage of the next higher resolution.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local

Abrégé

The present invention relates to a catalyst of Formula (I) wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, L1, M1, Q1, and Q2 have the meaning defined in the description and claims. The present invention also relates to a catalyst composition comprising at least one catalyst according to the invention, an optional activator; an optional support; and an optional co-catalyst. The present invention also relates to the use of a catalyst or catalyst composition according to the invention for the preparation of an olefin polymer. The present invention also relates to an olefin polymerization process, the process comprising: contacting a catalyst or a catalyst composition according to the invention, with an olefin monomer, optionally hydrogen, and optionally one or more olefin comonomers; polymerizing the monomer, and the optionally one or more olefin comonomers, in the presence of the at least one catalyst composition, and optional hydrogen, thereby obtaining an olefin polymer. The present invention also relates to olefin polymers and articles comprising said olefin polymer.

Classes IPC  ?

• C08F 4/00 - Catalyseurs de polymérisation
• C08F 110/00 - Homopolymères d'hydrocarbures aliphatiques non saturés contenant une seule liaison double carbone-carbone
• C07F 17/00 - Metallocènes

Abrégé

PIM2 kinase deregulation has been reported in several cancers. In particular, PIM2 is considered in multiple myeloma as part of the oncogenic process and several PIM kinase inhibitors have been developed showing encouraging results in preclinical studies and clinical trials. Now the inventors have developed an antisense RNA strategy based on a splice-switching oligonucleotide (SSO) so as to induce efficient knockdown of PIM2 expression. This SSO-mediated knockdown is a powerful approach to for cancer treatments. Accordingly, the present invention relates to the use of splice switching oligonucleotides for exon skipping-mediated knockdown of PIM2.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The invention relates to an electromagnetic wave damping system including a dielectric support (7) having a first face and a second face, and at least one frequency damping element (6), characterised in that the at least one damping element comprises a first pattern (8) arranged on the first face of the support, and a second pattern (9) arranged on the second face of the support.

Classes IPC  ?

• H01Q 17/00 - Dispositifs pour absorber les ondes rayonnées par une antenneCombinaisons de tels dispositifs avec des éléments ou systèmes d'antennes actives
• H01Q 15/00 - Dispositifs pour la réflexion, la réfraction, la diffraction ou la polarisation des ondes rayonnées par une antenne, p. ex. dispositifs quasi optiques
• H01Q 1/40 - Éléments rayonnants recouverts avec, ou enrobés d'une matière protectrice

Abrégé

The present invention relates to a method for selecting at least one micropeptide able to alter the microbiome influenced by roots of a plant based on identifying miRNAs secreted by said plant in a sample of the roots and/or rhizosphere. The present invention also relates to a micropeptide able to alter the microbiome influenced by roots of a plant and its use as a plant microbiome modulating agent, for example for inducing a phenotype of interest, such as a pathogen resistance and/or a water resistance.

Classes IPC  ?

• A01H 1/00 - Procédés de modification des génotypes
• A01H 3/04 - Procédés de modification des phénotypes par traitement au moyen de produits chimiques
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A01N 33/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux contenant des composés organiques de l'azote

Abrégé

The present invention relates to a method for oxidative cleavage of a substrate consisting of at least one functionalised or non-functionalised linear olefin, in particular a mono- or polyunsaturated aliphatic carboxylic acid, or one of the esters thereof, or at least one non-functionalised cyclic olefin, using hydrogen peroxide, in the presence of a metal catalyst which consists of at least one onium halooxodiperoxometallate. It also relates to a novel catalyst consisting of a specific onium halooxodiperoxometallate which can be used, in particular, in said method.

Classes IPC  ?

• C07C 51/25 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par oxydation avec l'oxygène moléculaire de composés non saturés ne contenant pas de cycle aromatique à six chaînons
• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques

Abrégé

The present invention relates to a method of manufacturing a composite material comprising at least one ply (400) integrating at least one electronic element (200, 201, 202) situated at the surface of said ply (400), and to said materials obtained thereof and devices comprising such materials, said method comprising the following steps: a) preparing or providing a first substrate T (100) comprising at least one layer; b) applying at least one electronic element (200, 201, 202) onto a face of the said first substrate T (100); c) at least partially impregnating the so-obtained product within an impregnation material to form a matrix (302) incorporating the at least one electronic element (200, 201, 202) and the first substrate T (100); d) preparing or providing an impregnable second substrate P (301), said second substrate P (301) being placed on top of the impregnated at least one electronic element (200, 201, 202) so that the at least one electronic element is interposed between the first substrate T (100) and the second substrate P (300); e) removing the first substrate T (100) from the impregnated product obtained in step d); f) recovering the composite material.

Classes IPC  ?

• B29C 70/86 - Incorporation dans des couches de renforcement imprégnées cohérentes

Abrégé

A system for controlling the activation/deactivation of an electromagnetic shielding screen (11a, 11b, 11c, 11d) of a porthole or a protective window of an optoelectronic equipment, which includes, a radiofrequency electromagnetic sensor (1), with a bandwidth adapted to a cut-off band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, connected to a detector-rectifier (2) with a sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device (13, 14, 15, 16) for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured, in the presence of the electromagnetic field with a power exceeding said minimum value, to activate said device (13, 14, 15, 16) for activating/deactivating the electromagnetic shielding screen by capturing the electromagnetic energy supplied by said electromagnetic fields with a power exceeding said minimum value. Figure of the abstract: Figure 1

Classes IPC  ?

• G01J 5/06 - Dispositions pour éliminer les effets des radiations perturbatricesDispositions pour compenser les changements de la sensibilité

Abrégé

Control system for activating/deactivating an electromagnetic shielding screen (11a, 11b, 11c, 11d) of a porthole or of a window for protecting optoelectronic equipment, which comprises, a radiofrequency electromagnetic sensor (1), of passband matched to a blocking band of said shielding screen corresponding to a range of electromagnetic fields to be blocked, which is connected to a detector-rectifier (2) of sensitivity higher than a minimum value of the power of an electromagnetic field to be blocked by means of said shielding screen and a device (13, 14, 15, 16) for activating/deactivating said electromagnetic shielding screen, said detector-rectifier being configured to, in the presence of electromagnetic fields of power exceeding said minimum value, activate said device (13, 14, 15, 16) for activating/deactivating the electromagnetic shielding screen by capturing electromagnetic energy delivered by said electromagnetic fields of power exceeding said minimum value.

Classes IPC  ?

• G01J 5/06 - Dispositions pour éliminer les effets des radiations perturbatricesDispositions pour compenser les changements de la sensibilité

Abrégé

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

Classes IPC  ?

• A61K 31/404 - Indoles, p. ex. pindolol
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07D 209/12 - Radicaux substitués par des atomes d'oxygène
• C07D 471/04 - Systèmes condensés en ortho
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

Classes IPC  ?

• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• C07D 471/04 - Systèmes condensés en ortho