Abstract

The present invention relates to methods for amplifying and sequencing the full-length genome of a hepatitis C vims. The present invention also relates to primers and kits for amplifying and sequencing the full-length genome of a hepatitis C virus.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

A process of manufacturing component with a composite film including a matrix made of thermoplastic polymer and particles inside this matrix. This process includes heating the composite film in order for its temperature to exceed the glass transition temperature of its matrix, then when the composite film is softened, flattening an external face of the composite film by a smooth face resting directly over the whole of this external face, this smooth face forming part of the front face of a flexible membrane, the whole of the rear face of which, located on the side opposite the front face, is pushed against the composite film by a fluid, then cooling the composite film below the glass transition temperature, then withdrawing the membrane in order to mechanically separate its front face from the external face of the composite film.

IPC Classes  ?

• B05D 3/12 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
• B32B 33/00 - Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
• B32B 37/10 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the pressing technique, e.g. using direct action of vacuum or fluid pressure
• B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
• B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
• B29C 70/58 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising fillers only
• B29C 70/88 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts characterised primarily by possessing specific properties, e.g. electrically conductive or locally reinforced
• B30B 5/02 - Presses characterised by the use of pressing means other than those mentioned in groups and wherein the pressing means is in the form of a flexible element, e.g. diaphragm, urged by fluid pressure
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
• B32B 7/02 - Physical, chemical or physicochemical properties
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
• B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
• B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
• B32B 27/34 - Layered products essentially comprising synthetic resin comprising polyamides
• B32B 27/36 - Layered products essentially comprising synthetic resin comprising polyesters

Abstract

A computer-implemented method for automatically identifying a faulty behavior of a control system. The method includes receiving, at a test processor, a description of the faulty behavior. The method also includes selecting, using the test processor, a goal state based on a heuristic decision. The method also includes selecting, using the test processor, a selected system state. The method also includes selecting, using the test processor, a selected variable to the control system based on the goal state. The method also includes loading, from a memory, a control model of the control system. The method also includes performing, using the test processor, a simulation of the control model using the selected variable and the selected system state as parameters of the simulation. The method also includes determining, using the test processor, whether the faulty behavior was observed based on the simulation.

IPC Classes  ?

• G06F 11/00 - Error detection; Error correction; Monitoring
• G06F 11/36 - Preventing errors by testing or debugging of software

Abstract

The invention relates to a composition comprising all or part of the aleurone layer of a cereal for the use thereof in the prevention or treatment of alterations induced by at least one pollutant, especially contained in a food.

IPC Classes  ?

• A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• A61K 36/8998 - Hordeum (barley)

Abstract

A microelectronic method for etching a layer to be etched, including: modifying the layer to be etched from a surface of the layer to be etched and over a depth corresponding to at least a portion of thickness of the layer to be etched to form a film, with the modifying including implanting light ions into the layer to be etched; and removing the film includes a selective etching of the film relative to at least one layer underlying the film.

IPC Classes  ?

• H01L 21/302 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to change the physical characteristics of their surfaces, or to change their shape, e.g. etching, polishing, cutting
• H01L 21/311 - Etching the insulating layers
• H01L 21/306 - Chemical or electrical treatment, e.g. electrolytic etching
• H01L 21/3213 - Physical or chemical etching of the layers, e.g. to produce a patterned layer from a pre-deposited extensive layer
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/266 - Bombardment with wave or particle radiation with high-energy radiation producing ion implantation using masks

Abstract

A method for the automated manufacture of an electronic circuit tolerant to faults by temporal redundancy of maximum order N, comprising a step implemented by computer, which involves replacing any memory cell of the circuit with a memory block (40) comprising a chain of memory cells in series, and a selection block which selects, in a temporal redundancy mode of order n1, n1 ∈ [1,N], as output data of the memory block, the majority content of n1 cells of the block, and can further deliver a fault signal if the content of the n1 cells differs. Said method is characterised in that the inserted memory blocks allow dynamic switching from a temporal redundancy mode of order n1 to any other mode of order n2. Said method for N=2, in association with a recording mechanism with backward recovery, makes it possible to mask an error with only double redundancy instead of triple redundancy.

IPC Classes  ?

• G06F 17/50 - Computer-aided design
• H03K 3/037 - Bistable circuits

Abstract

The invention relates to a bioreactor obtained by compression of a mixture comprising an enzyme and a conductor, the inactive surfaces of the bioreactor being coated with impermeable parylene (32), and each active surface of the bioreactor being coated with a nano-porous membrane of parylene (40) glued along the periphery thereof.

IPC Classes  ?

• H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells

Abstract

The invention concerns a device for measuring parasitic movements in a sample (5) to be analysed in an X-ray tomography apparatus, the device comprising: a source (1) emitting an X-ray beam (6) to a detector (3), the sample, carried by a support (13), being traversed by the beam; and a sight (17) carrying at least three balls (21) that are opaque to X-rays, the sight being attached to said support such that, on the detector, images (25) of the balls are around an image (16) of the sample, the shape and the materials of the sight being chosen such that the positions of the balls relative to the support are insensitive to temperature variations.

IPC Classes  ?

• G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material

Abstract

The invention relates to a device for the radio transmission of a data word between a transmitter (1) and a receiver (65), comprising a transmitter (1) that can transmit at least one block of data comprising a preamble word and a data word repeated several times; an elementary synchronisation block allowing the synchronisation of the receiver (65) to the transmitter (1) and the detection of the preamble word; and a synchronous averaging device (67) calculating the average of the data word repeated.

IPC Classes  ?

• H04B 1/69 - Spread spectrum techniques
• H04B 3/54 - Systems for transmission via power distribution lines

Abstract

The invention concerns a bioreactor obtained by compressing a mixture of an enzyme, a conductor and chitosan. The conductor can consist of carbon nanotubes. This bioreactor can be produced according to the following steps: preparing a mixture of powders in which the proportion of enzyme powder relative to a carbon nanotube powder is of the order of 50/50 by weight; preparing a viscous solution of chitosan in a ratio of 5 to 15 (in mg) of chitosan to 0.75 to 1.25 (in ml) of acetic acid diluted to 0.4 to 0.6 % by volume in water; adding the viscous chitosan to the mixture of powders in a proportion be weight of 3 to 5 of powder to 5 to 10 of chitosan; carrying out a first compression followed by light grinding; carrying out a second compression to produce a pellet; and drying at ambient temperature.

IPC Classes  ?

• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 4/88 - Processes of manufacture
• H01M 4/90 - Selection of catalytic material
• H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts

Abstract

Multimenic lectins having a β-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61K 49/14 - Peptides, e.g. proteins
• A23J 3/20 - Proteins from microorganisms or unicellular algae

Abstract

The invention relates to a voltage converter (100), including: a plurality of two-way conversion cells (303), each cell comprising a primary circuit (307, Wp), and a secondary circuit (308, Ws) that is insulated from the primary circuit, wherein each circuit can be separately activated in order to supply an output voltage from the converter; and at least one control circuit (306) configured to, in a first operating mode, control the activated cells in order to transfer electrical energy from the primary circuit to the secondary circuit, and control the inactivated cells in order to transfer electrical energy from the secondary circuit to the primary circuit.

IPC Classes  ?

• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 1/36 - Means for starting or stopping converters
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion

Abstract

The invention relates to a method for the in vitro detection of strains of Legionella pneumophila that are resistant to antibiotics, especially fluoroquinolones. The invention also relates to nucleotide probes and to a kit of reagents allowing the detection of bacterial strains of Legionella pneumophila that are resistant to antibiotics, especially of the fluoroquinolone type.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention concerns a spacer (300) comprising a first part (321) made from a first shape memory material, and a second part (323) made from a second shape memory material.

IPC Classes  ?

• A61F 2/88 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils

Abstract

The present invention relates to a heat exchange structure implementing heat transfer by boiling a liquid and comprising a substrate and at least one layer intended to be in contact with a liquid and disposed at least partially on the substrate. The composition of this layer comprises at least one molecular switch having a lower critical solution temperature TLCST above which it gives the layer non-wetting properties with regard to the liquid and below which it gives the layer wetting properties with regard to the liquid, said lower critical solution temperature TLCST of the molecular switch being chosen so as to be greater than or equal to the saturation temperature Tsat of the liquid. The present invention also relates to an assembly and to a heat exchange device comprising such a structure, to the uses of same and to the methods for producing such a structure and assembly.

IPC Classes  ?

• F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing

Abstract

A method for processing cardiac signals includes accepting, from a sensor system, a set of one or more signals, the signals including components of a desired cardiac signal and components of a substantially periodic interfering signal. The method is applicable for extraction of desired fetal cardiac signals from signals with interference from the maternal cardiac signal. A periodicity of the interfering signal is determined, and one or more iterations of mitigating an effect of a component of the signals that exhibit periodicity at the determined periodicity of the interfering signal are performed. In some examples, the method further includes determining a periodicity of the desired cardiac signal, and performing one or more iterations of enhancing an effect of a component of the signals that exhibit periodicity at the determined periodicity of the desired cardiac signal.

IPC Classes  ?

• A61B 5/0444 - Foetal cardiography
• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The invention concerns a plasma generator in a vacuum chamber comprising at least one elementary generator opening into the chamber, the elementary generator comprising: - a microwave generator, - an impedance adapter extending in a coaxial direction, the adapter being configured to adapt the impedance of the plasma to the impedance of the microwave generator and to protect the microwave generator, the microwave generator being located in the extension of the adapter and connected directly to the adapter.

IPC Classes  ?

• H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy
• H01J 37/32 - Gas-filled discharge tubes
• H01P 7/04 - Coaxial resonators

Abstract

The invention relates to a matrix device for measuring characteristics of an X-ray beam. Said device includes a first set (32) of detection cells of a size different from the cells of at least one second set (33, 34) of detection cells. Each cell corresponds to an ionization chamber including a detection electrode. The detection electrodes of all the cells have the same effective surface for collecting charges.

IPC Classes  ?

• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation

Abstract

The invention relates to a method for producing a Schottky diode, comprising the following steps: a) oxygenating the surface of a semiconductive layer (105) of monocrystalline diamond, in such a way as to replace hydrogen surface terminations of the semiconductive layer (105) with oxygen surface terminations; and b) forming, by physical vapour deposition, a first conductive layer of zirconium or indium-tin oxide on the surface of the semiconductive layer (105).

IPC Classes  ?

• H01L 21/285 - Deposition of conductive or insulating materials for electrodes from a gas or vapour, e.g. condensation
• H01L 29/47 - Schottky barrier electrodes
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

The invention relates to a supercapacitor (10) to be submerged in a medium (15) containing a biological material and an oxidant, wherein the anode (A) comprises a first enzyme that can catalyse the oxidation of the biological material and the cathode (K) comprises a second enzyme that can catalyse the reduction of the oxidant, and wherein each of the anode and cathode electrodes consists of a solid agglomerate of a conductive material mixed with the first or the second enzyme, said agglomerate having a specific surface that is larger than or equal to 20 m2/g and an average pore size varying between 0.7 nm and 10 pm.

IPC Classes  ?

• H01G 11/36 - Nanostructures, e.g. nanofibres, nanotubes or fullerenes
• H01G 11/62 - Liquid electrolytes characterised by the solute, e.g. salts, anions or cations therein

Abstract

The invention relates to an implantable energy source comprising at least one energy storage sub-system (171) constructed in the form of a stack of thin layers (175) on a substrate (176), characterised in that said energy storage sub-system has a plurality of through-openings (174) for allowing the development and the passage of blood vessels. Preferably, the energy source thereof has a thickness of less than, or equal to, 1 mm, over at least 80% of its surface.

IPC Classes  ?

• A61N 1/378 - Electrical supply
• H01L 31/042 - PV modules or arrays of single PV cells

Abstract

The invention relates to a microelectronic method for etching a layer to be etched, comprising the following steps: - modifying the layer to be etched from the surface of the layer to be etched and over a depth corresponding to at least a portion of the thickness of the layer to be etched so as to form a film, the modification comprising implanting light ions in the layer to be etched; - removing the film comprising a selective etching of the film relative to at least one layer underlying the film.

IPC Classes  ?

• H01L 21/306 - Chemical or electrical treatment, e.g. electrolytic etching
• H01L 21/311 - Etching the insulating layers
• H01L 21/3213 - Physical or chemical etching of the layers, e.g. to produce a patterned layer from a pre-deposited extensive layer

Abstract

A method for removing a part from a mold and to a machine for molding the part, the part made of a material having a glass-transition temperature and a melting temperature that is higher than the glass-transition temperature, and which is shaped in the cavity of a mold, includes at least two mold portions defining the shaping cavity therebetween. The mold is at a temperature between the glass-transition temperature and the melting temperature. The method includes opening the mold by spacing apart the mold portions, locally spraying a cooling gas toward the part remaining in a portion of the mold using at least one nozzle, and, after a predetermined time period following the start of spraying the gas, ejecting the part from the portion of the mold, the time period being such that the part reaches a temperature that is lower than the glass-transition temperature thereof.

IPC Classes  ?

• B22D 17/22 - Dies; Die plates; Die supports; Cooling equipment for dies; Accessories for loosening and ejecting castings from dies
• B22D 25/06 - Special casting characterised by the nature of the product by its physical properties
• B22D 27/04 - Influencing the temperature of the metal, e.g. by heating or cooling the mould
• B22D 29/00 - Removing castings from moulds, not restricted to casting processes covered by a single main group; Removing cores; Handling ingots
• B22D 30/00 - Cooling castings, not restricted to casting processes covered by a single main group

Abstract

System (3) for the reversible storage of hydrogen, comprising: at least one reservoir (9) comprising a material (11) for storing hydrogen by absorption in the form of a metal hydride and for releasing hydrogen from storage by desorption; and at least one device (13) in thermal contact with the material in order, on the one hand, to extract heat from the material while the hydrogen is being absorbed, the device being intended to be in thermal contact with a cold source (7) receiving the extracted heat and, on the other hand, to supply heat to the material during the desorption of the hydrogen, the device being intended to be in thermal contact with a hot source (5) supplying the added heat. The device comprises a plurality of heat pipes (41-43-45) for transporting at least a fraction of the added heat and/or for transporting at least a fraction of the extracted heat. Assembly comprising such a system and a hot source and a cold source both in thermal contact with the device.

IPC Classes  ?

• F17C 11/00 - Use of gas-solvents or gas-sorbents in vessels

Abstract

The invention relates to an electrode, to the method for manufacturing same and to a device for storing and delivering electric power including same. The electrode of the invention includes a mounting, made of a conductor or semiconductor material, said mounting including, on at least one of the surfaces thereof, at least one nanostructure made of a semiconductor material, characterised by also including a protective layer made of a material selected among a dielectric material having an intrinsic capacity of 1.5 10-6 to 10 10-6 F/cm2 and a metal, said layer having a thickness that is less than the height of said nanostructure, and covering the at least one nanostructure. The invention is useful in the field of electrochemical storage and, in particular, in the field of ultracapacitors.

IPC Classes  ?

• H01G 11/24 - Electrodes characterised by the structural features of powders or particles used therefor
• H01G 11/30 - Electrodes characterised by their material
• H01G 11/48 - Conductive polymers
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01M 4/134 - Electrodes based on metals, Si or alloys

Abstract

The invention relates to a radiofrequency propagation line including a conducting strip (31) connected to a conducting plane (37) parallel to the plane of the conducting strip, wherein the conducting plane includes a network of nanowires (36) made of an electrically conductive, non-magnetic material extending orthogonally to the plane of the conducting strip, in the direction of said conducting strip.

IPC Classes  ?

• H01P 3/00 - Waveguides; Transmission lines of the waveguide type
• H01P 3/08 - Microstrips; Strip lines

Abstract

The invention relates to a novel use of ultrafine nanoparticles, which are of use as a diagnostic, therapeutic or theranostic agent, characterized by the mode of administration thereof via the airways. The invention is also directed towards the uses which follow from this new mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of lung diseases. In the therapeutic field, the uses envisaged are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), for neutron therapy, and of agents for PDT (photodynamic therapy), in particular for treating lung tumours.

IPC Classes  ?

• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/18 - Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle.

IPC Classes  ?

• C07K 9/00 - Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• A61K 49/00 - Preparations for testing in vivo

Abstract

The invention relates to a voltage converter (100), including: a plurality of two-way conversion cells (303), each cell comprising a primary circuit (307, Wp), and a secondary circuit (308, Ws) that is insulated from the primary circuit, wherein each circuit can be separately activated in order to supply an output voltage from the converter; and at least one control circuit (306) configured to, in a first operating mode, control the activated cells in order to transfer electrical energy from the primary circuit to the secondary circuit, and control the inactivated cells in order to transfer electrical energy from the secondary circuit to the primary circuit.

IPC Classes  ?

• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 1/36 - Means for starting or stopping converters
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion

Abstract

The present invention relates to pyrrolic derivatives I, processes for their preparation, and their use as new antibacterial drugs.

IPC Classes  ?

• C07D 207/333 - Radicals substituted by oxygen or sulfur atoms
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61P 31/04 - Antibacterial agents

Abstract

A device for crystallizing a molecule to be crystallized, which includes: at least one crystallization cell that includes a crystallization chamber for receiving a first solution S1 containing the molecule to be crystallized and the crystal seeds thereof, a dialysis membrane, and a container to be filled with a second solution S2 that contains constituents selected from the group containing crystallization agents, additives and buffers; and at least one image acquisition means. The crystallization device is characterized in that it includes: at least one addition means arranged to add, to the container, constituents selected from the group containing crystallization agents, additives and buffers of solution S2; and/or at least one sampling means arranged to collect, from the container, all or a portion of solution S2. The invention also relates to a crystallization method.

IPC Classes  ?

• C30B 7/08 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
• C30B 7/00 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
• C30B 29/54 - Organic compounds
• C30B 29/58 - Macromolecular compounds

Abstract

The invention relates to a method for producing a component comprising a conductive grid (9) insulated from a semiconductor monocrystalline diamond substrate (2) by an insulating region (7), comprising the following steps: a) oxygenating the surface of the substrate (2) so as to replace the hydrogen surface terminations of the substrate with oxygen surface terminations; and b) forming the insulating region (7) on the surface of the substrate (2) by repeated monatomic layer deposition (ALD).

IPC Classes  ?

• H01L 21/28 - Manufacture of electrodes on semiconductor bodies using processes or apparatus not provided for in groups
• H01L 29/51 - Insulating materials associated therewith
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 21/314 - Inorganic layers
• H01L 29/49 - Metal-insulator semiconductor electrodes

Abstract

The present invention relates to a protein complex isolated from its natural environment and comprising the ZEBRA protein of sequence SEQ ID NO: 1, said isolated protein complex having the following properties: - it is more stable than the ZEBRA protein, in particular it is more resistant to the action of proteases than the ZEBRA protein, - it is capable of specifically binding the AZ125 and AZ130 monoclonal antibodies, - it is soluble in a biological fluid, and in particular in a biological fluid chosen from the group consisting of blood and serum, and to the method for demonstrating said complex and the uses of this method for the prognosis or diagnosis of lymphoproliferative episodes associated with EBV.

IPC Classes  ?

• C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C07K 14/05 - Epstein-Barr virus

Abstract

The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.

IPC Classes  ?

• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C07C 59/215 - Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen-containing groups

Abstract

The invention relates to a device for measuring an atomic force, comprising a beam (1) whereof a first end carries a microtip (2); a microtip position sensor (6); means (4) of moving the second end of the beam in the axis z of the microtip; a low-frequency servo loop (13) using a signal (11) of the detector and acting on the means of moving to keep the microtip fixed when the force applied to the microtip varies; whereby the variation in force, ΔF, is given by the expression ΔF = k Δz, where k designates the stiffness of the beam and Δz the movement of the means of moving.

IPC Classes  ?

• G01Q 60/32 - AC mode
• G01Q 60/36 - DC mode
• G01Q 10/06 - Circuits or algorithms therefor
• B82Y 35/00 - Methods or apparatus for measurement or analysis of nanostructures

Abstract

The invention relates to a method for functionalizing an electrically conductive substrate, which is not a substrate made of gold, via a layer of chemical compounds, said method comprising the following steps: - a step in which the electrically conductive substrate is placed in contact with chemical compounds comprising at least a disulfide terminal group; - a step in which the disulfide terminal group of said chemical compounds is electro-oxidized, causing said chemical compounds to form a layer at the surface of the electrically conductive substrate.

IPC Classes  ?

• B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
• B05D 3/14 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
• C07D 257/00 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
• C07D 339/00 - Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
• G11B 9/00 - Recording or reproducing using a method or means not covered by one of the main groups ; Record carriers therefor
• G11C 11/00 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
• C07D 409/00 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

Abstract

The invention relates to an optical device for the interferometric analysis of the condition of the internal surface of a tube (11). The device comprises an optical fibre (3), the free end of which is pointed and then bevelled at the single core thereof and the bevelled surface is metallised (10), such that only part of the surface of the fibre core participates in reflecting the incident beam perpendicularly to the axis of the fibre.

IPC Classes  ?

• G01B 9/02 - Interferometers
• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures

Abstract

The present invention relates to an adhesion substrate for at least one animal or human cell, at the surface of which an adhesion unit for at least one animal or human cell is created, said unit comprising at least two zones which adhere to said cell, which are spaced apart by a zone which does not adhere to said cell, on which a polymer which does not adhere to said cell is immobilized, characterized in that the polymer is selected so as to exhibit a conformation which can be modified by variation of a parameter of the environment in which the substrate is situated, to a method for preparing such a substrate and to the cell analysis methods using such a substrate.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

IPC Classes  ?

• C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/4045 - Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• A61P 31/04 - Antibacterial agents

Abstract

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

IPC Classes  ?

• C07D 209/16 - Tryptamines
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/4045 - Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• A61P 31/04 - Antibacterial agents

Abstract

The invention relates to small cell penetrating peptides (CPP) derived from the scorpion toxin maurocalcine and to their use as vectors for the intracellular delivery of various drugs and agents.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans

Abstract

The invention relates to a method for removing a part from a mold and to a machine for molding said part, which is in particular made of a material having a glass-transition temperature and a melting temperature that is higher than the glass-transition temperature, and which is shaped in the cavity of a mold including at least two mold portions (3, 4) defining said shaping cavity (5) therebetween, wherein the mold is at a temperature between said glass-transition temperature and said melting temperature, and wherein the method comprises: opening the mold by spacing apart said mold portions (3, 4); locally spraying a cooling gas toward the part remaining in a portion of the mold using at least one nozzle (9); and, after a predetermined time period following the start of spraying the gas, ejecting the part from said portion of the mold, the time period being such that the part reaches a temperature that is lower than the glass-transition temperature thereof.

IPC Classes  ?

• B22D 17/22 - Dies; Die plates; Die supports; Cooling equipment for dies; Accessories for loosening and ejecting castings from dies
• B22D 27/04 - Influencing the temperature of the metal, e.g. by heating or cooling the mould
• B22D 29/00 - Removing castings from moulds, not restricted to casting processes covered by a single main group; Removing cores; Handling ingots
• B22D 30/00 - Cooling castings, not restricted to casting processes covered by a single main group

Abstract

The present invention relates to a method for predicting and/or diagnosing vascular alterations associated with a disorder in a patient, comprising a step of detecting or quantifying the presence of anti-VE-cadherin autoantibodies in a biological sample obtained from said patient as well as a kit suitable for carrying out such method.

IPC Classes  ?

• G01N 33/564 - Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease

Abstract

The invention relates to novel grafted dinuclear metal complexes of formula (I) or of formula (II) in which M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterizing cellular microparticles.

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The invention relates to a method and a device for forming metallic-glass beads from a metal alloy. The metal alloy, heated in a crucible (7) to a temperature at least equal to the melting point thereof, is extruded through at least one extrusion hole (10) provided in the lower portion of the crucible, so as to flow downward and form a series of separate drops (G) of melted metal alloy, said drops of melted metal alloy entering a cooling liquid (L) so as to solidify, thereby forming metallic-glass beads (B).

IPC Classes  ?

• B22F 9/06 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from liquid material
• B22F 9/08 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from liquid material by casting, e.g. through sieves or in water, by atomising or spraying
• C22C 45/00 - Amorphous alloys

Abstract

The present invention relates to compounds of formula (I), where R1 and R2, identical or different, are each independently a hydrogen atom or a non-substituted or substituted (C1-C12) alkyl group; R3 is a hydrogen atom or a non-substituted or substituted (C1-C6) alkyl group; R4 is a non-substituted or substituted (C1-C12) alkyl group or an aryl or heteroaryl group, said aryl and heteroaryl groups being non-substituted or substituted; and R5 is a non-substituted or substituted (C1-C12) alkyl group; or R4 and R5 are bonded to one another by a saturated hydrocarbon chain having 3 or 4 carbon atoms, optionally in hydrated form or in the form of a salt that is acceptable for being administered to animals or plants, for the use thereof as a potentiator of the effect of an antimicrobial agent or for the use thereof as an antimicrobial agent.

IPC Classes  ?

• C07D 215/06 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
• A61K 31/404 - Indoles, e.g. pindolol

Abstract

The invention relates to a method for the in vitro diagnosis of a brain tumour belonging to the group consisting of two types of tumours - ODG and GBM - and the identification of the type of tumour, comprising the measurement of the expression levels of at least one first and one second miRNA respectively belonging to two different miRNA groups, in a sample from a patient suspected of having one of said brain tumours.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for the in vitro diagnosis of a brain tumour belonging to the group consisting of two types of tumours - ODG and GBM - and the identification of the type of tumour, comprising the measurement of at least two ratios of the expression levels of miRNA pairs extracted from a biological sample from a patient suspected of having one of said brain tumours.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention pertains to rechargeable metal ion cell comprising: - an anode comprising at least one metal; - a charge-carrying electrolyte comprising a charge carrying medium and at least one metal salt; - an organic polymer cathode, wherein said cathode comprises at least one N- substituted polyphenothiazine polymer [polymer (P)], said polymer comprising at least one N-substituted phenothiazine recurring unit of formula: wherein R' is an electron-withdrawing group comprising at least one heteroatom selected from O, S, P and N.

IPC Classes  ?

• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 4/137 - Electrodes based on electro-active polymers
• C07D 279/18 - [b, e]-condensed with two six-membered rings
• C07D 279/22 - [b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
• C07D 279/30 - [b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with acyl radicals attached to the ring nitrogen atom

Abstract

The invention relates to compounds of formula (I) where: R1 ≠ 2-deoxystreptamine and the derivatives thereof substituted in positions 5 and/or 6; R2 and R6 are the same or different and represent a primary, secondary or tertiary amine function: NH2, NHR, NRR' where R and R' = alkyl, aryl, cyclic or otherwise, substituted or otherwise; OR3 and OR4 form alcohol, ether, ester, carbonate, carbamate, sulfonate or sulfamate functions; and if R3 = R4, then R3 and R4 ≠ H; if R3 = H, then R4 ≠ H and R1 ≠ OH; and if R4 = H, then R3 ≠ H and R1 ≠ OH; if R1 = OH, then R3 and R4 ≠ H, and if R1 = OR5, then R3 and/or R4 and/or R5 are not a sugar or a polysaccharide. The invention further relates to the use of said compounds as drugs and, specifically, as antibiotics.

IPC Classes  ?

• A61K 31/7008 - Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61P 31/04 - Antibacterial agents
• C07H 15/18 - Acyclic radicals, substituted by carbocyclic rings

Abstract

The invention relates to a writable magnetic element comprising a film multilayer containing a write magnetic film, characterized in that the multilayer comprises a central film (13, 53, 100) made of at least one magnetic material having a magnetization with a magnetization direction parallel to the plane of the central film (13, 53, 100), the latter being sandwiched between a first external film (12, 52, 101) and a second external film (14, 54, 102) both made of non-magnetic materials, the first external film (12, 52, 101) comprising a first non-magnetic material and the second external film (14, 54, 102) comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and in that the element comprises a device for making a write current flow through the second external film (14, 54, 102) and the central film (13, 53, 100) in a flow direction parallel to the plane of the central film (13, 53, 100) and at an angle α of 90o ± 60o, especially of 90o ± 30o and more particularly 90o ± 15o to said magnetization direction, so as to generate a useful magnetic field in the central film (13, 53, 100), this current being made to flow either in a first direction, or in a second direction opposite to the first direction, so as to orient the magnetization direction in a first magnetization direction or in a second magnetization direction opposite to the first magnetization direction.

IPC Classes  ?

• G11C 11/14 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using thin-film elements
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H01L 27/22 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate using similar magnetic field effects

Abstract

The present invention relates to the use of at least one element for the implementation of a prognosis method, preferably in vitro, of the survival rate of a patient afflicted by a lung cancer, said lung cancer being previously classified as a lung tumour belonging from the group consisting of squamous cell carcinoma (SQC), adenocarcinoma (ADK), large cell neuro-endocrine tumours (LCNE) and basaloid tumours (BAS).

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting magnetization having a magnetization direction that is parallel to the plane of the central layer, which layer is sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and wherein it includes a device to cause a write current to pass through the second outer layer and the central layer in a current flow direction parallel to the plane of the central layer at an angle α lying in the range 90°±60°, in particular 90°±30°, and more particularly 90°±15° relative to said magnetization direction in order to generate an effective magnetic field in the central layer, the current being applied either in a first direction or in a second direction opposite to the first, in order to orient the magnetization direction in a first magnetization direction or in a second magnetization direction opposite to the first.

IPC Classes  ?

• H01L 21/00 - Processes or apparatus specially adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof

Abstract

The invention relates to the use of at least 13 genes chosen among a set of 28 genes for carrying out a method for identifying at least 66% of patients of those having a survival rate of at most about 20% at 30 months, among a population of patients afflicted by lung cancer having an estimated survival rate of at least 30% at 30 months based on the diagnosis of said lung cancer according to histopathological criteria.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The invention relates to a silicon sintering process, with no external force added, which comprises positioning a silicon sample in a furnace and then heat-treating this sample at least at a certain temperature and with at least a partial pressure of oxidizing species in order to control the thickness of a silicon oxide layer on the surface thereof.

IPC Classes  ?

• B22F 3/10 - Sintering only
• C01B 33/037 - Purification
• H01L 31/0368 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their crystalline structure or particular orientation of the crystalline planes including polycrystalline semiconductors
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The invention relates to an electrochemical generator comprising a first electrode covered by a passivation layer having a compound formed by the repetition of a unit of formula (7) in which n is an integer between 1 and 10, preferably between 1 and 4; R1 and R2 are identical or different and chosen independently from the group formed by -CH2- and a cyclic or acyclic, linear or branched alkyl chain; R3 is chosen from the group formed by -CH3, a cyclic or acyclic, linear or branched alkyl chain and a group of formula (8) in which: A' is a monocyclic or polycyclic, aromatic hydrocarbon group, chosen from the group formed by phenyl, aryl groups and condensed, polyaromatic groups, these being optionally substituted; R4 is chosen from the group formed by -CH2- and a cyclic or acyclic, linear or branched alkyl chain; and A is identical to or different from A'. The unit has no hydroxyl functions and is grafted onto the first electrode via group A, and when R3 is a group of formula (8), via groups A and A'.

IPC Classes  ?

• H01M 10/052 - Li-accumulators
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodes; Lithium-ion batteries
• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/0563 - Liquid materials, e.g. for Li-SOCl2 cells

Abstract

The invention relates to an aryl diazonium salt free of hydroxyl functions of general formula (1) in which n is an integer between 1 and 10, preferably between 1 and 4, X" represents a counterion of the diazonium cation chosen from halides, BF4-, NO3-, HSO4-, PF6-, CH3COO-, N(SO2CF3)2-, CF3SO3-, CH3SO3-, CF3COO-, (CH3O)(H)PO2-, N(CN)2-, R1, R2 and R4 are identical or different and are chosen independently from the group constituted by -CH2-, a cyclic or acyclic, linear or branched alkyl chain and A and A' are identical or different and independently represent a monocyclic or polycyclic aromatic hydrocarbon-based group chosen from the group constituted by phenyl, aryl groups, and condensed polyaromatic groups, which are optionally substituted.

IPC Classes  ?

• C07C 245/20 - Diazonium compounds
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 10/36 - Accumulators not provided for in groups
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulators; Processes of manufacture thereof

Abstract

The invention relates to a high-frequency transmission line comprising a central conductor strip (6) associated with at least one conductor shielding plane (4). In said transmission line, at least some of the space between the conductor plane and the conductor strip comprises a ferroelectric material (10).

IPC Classes  ?

• H01P 3/00 - Waveguides; Transmission lines of the waveguide type
• H01P 1/18 - Phase-shifters

Abstract

The invention relates to a biopile electrode or biosensor electrode intended to be immersed in a liquid medium containing a target and an oxidizer, respectively a reducer, in which the anode comprises an enzyme able to catalyse the oxidation of a target, and the cathode comprises an enzyme able to catalyse the reduction of the oxidizer, and in which each of the anode electrode and cathode electrode consists of a solid agglomeration of carbon nanotubes mixed with the enzyme, and is secured to an electrode wire.

IPC Classes  ?

• H01M 4/90 - Selection of catalytic material
• H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• H01M 4/88 - Processes of manufacture

Abstract

The invention relates to a writeable magnetic element, comprising a stack of layers having a magnetic writing layer, characterised in that the stack comprises a central layer (13, 53, 90) made of at least one magnetic material having a direction of magnetisation that is parallel or perpendicular to the plane of the central layer, wherein said central layer, which forms such a magnetic writing layer, is sandwiched between a first (12, 52, 91) and second (14, 54, 92) outer layer made of non-magnetic materials, the first outer layer (12, 52, 91) comprising a first non-magnetic material and the second outer layer (14, 54, 92) comprising a second non-magnetic material other than the first non-magnetic material, wherein at least the second non-magnetic material is electrically conductive, and characterised in that said element comprises a device for passing a writing current only through the second outer layer and the central layer, and optionally through the first outer layer only in the event the latter is conductive, said writing current circulating in a current direction that is parallel to the plane of the central layer, as well as a device for applying, in the presence of said writing current, a writing magnetic field in a magnetic-field direction that is perpendicular to the plane of the central layer (13, 53, 90), the memory being written to in one of the directions of magnetisation by controlling the direction of the applied writing magnetic field.

IPC Classes  ?

• H01L 43/08 - Magnetic-field-controlled resistors
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices

Abstract

The invention relates to a writeable magnetic element, comprising a stack of layers having a magnetic writing layer, characterised in that the stack comprises a such a magnetic writing layer, namely a central layer (13, 53, 70, 23, 63, 80) made of at least one magnetic material having a direction of magnetisation that is parallel or perpendicular to the plane of the central layer, which is sandwiched between a first (12, 52, 71, 22, 62) and second (14, 54, 72, 24, 64, 82) outer layer made of non-magnetic materials, the first outer layer (12, 52, 71, 22, 62) comprising a first non-magnetic material and the second outer layer (14, 54, 72, 24, 64, 82) comprising a second non-magnetic material other than the first non-magnetic material, wherein at least the second non-magnetic material is electrically conductive, and characterised in that said element comprises a device for passing a writing current only through the second outer layer and the central layer, and optionally through the first outer layer only in the event the latter is conductive, said writing current circulating in a current direction that is parallel to the plane of the central layer, as well as a device for applying a magnetic field having a component in one magnetic-field direction that is either parallel or perpendicular to the plane of the central layer (13, 53, 70, 23, 63, 80) and to the current direction, and in that the direction of magnetisation and the magnetic-field direction are mutually perpendicular.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

Abstract

The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting a direction of magnetization that is perpendicular to the plane of the central layer, said central layer being sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and wherein it includes a device for causing current to flow through the second outer layer in a current flow direction parallel to the plane of the central layer, and a device for applying a magnetic field along a magnetic field direction that is perpendicular to the plane of the central layer.

IPC Classes  ?

• H01L 29/82 - Types of semiconductor device controllable by variation of the magnetic field applied to the device

Abstract

The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting a direction of magnetization that is parallel or perpendicular to the plane of the central layer, said central layer being sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, wherein it includes a device for causing current to flow through the second outer layer and the central layer in a current flow direction parallel to the plane of the central layer, and a device for applying a magnetic field having a component along a magnetic field direction that is either parallel or perpendicular to the plane of the central layer and the current flow direction, and wherein the magnetization direction and the magnetic field direction are mutually perpendicular.

IPC Classes  ?

• G11C 11/14 - Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using thin-film elements

Abstract

The present invention relates to a device for controlling a blood flow produced in a hemorrhagic area (4) of biological tissue (8), including a flexible plate (2) that is arranged so as to be placed opposite said area (4) and includes: a substantially sealed peripheral bearing means (3) capable of being applied onto the biological tissue (8) while surrounding the hemorrhagic area; a bottom wall (5) that defines, together with the bearing means (3), a hollow space (6) opposite the area (4); a connection means (14, 15) arranged so as to connect the hollow space (6), outside the flexible plate (2), to an outer suction source so as to create, within the hollow space (6), a vacuum for suctioning and tightly applying the surface (7) of the tissue (8) against the peripheral bearing means (3); and a hollow contact pad (11) which is placed between the area (4) and the bottom wall (5), which has a recess in the center thereof on the area (4) side and along an axis (10) substantially perpendicular to the bottom wall, and which is arranged so as to be in contact with the area (4) when the vacuum is created in the space (6).

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
• A61M 27/00 - Drainage appliances for wounds, or the like
• A61B 17/30 - Surgical pincettes

Abstract

The present invention relates to a hemostatic device (23) for controlling a blood flow occurring in a hemorrhagic zone (4) located in a hollow component, comprising: - a flexible plate (26) equipped with two opposing faces (27, 28), substantially parallel, said plate comprising an empty internal volume (29) between its two faces, and - connection means (30) linked for connecting the internal volume (29) to suction means external to said device, so as to create a depression in this internal volume (29), said connection means typically comprising a connecting tube (31), each of the faces (27, 28) being equipped with holes (32) that communicate, via these faces (27, 28), the internal volume (29) and the exterior of the plate such that when said depression is created in the internal volume, the suction is applied simultaneously to two opposite walls of the hollow component so as to keep them close together.

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

The present invention relates to a device for controlling a blood flow produced in a hemorrhagic area (4) of biological tissue (8), including a flexible plate (2) that is arranged so as to be placed opposite said area (4) and includes: a substantially sealed peripheral bearing means (3) capable of being applied onto the biological tissue (8) while surrounding the hemorrhagic area; a bottom wall (5) that defines, together with the bearing means (3), a hollow space (6) opposite the area (4); a connection means (14, 15) arranged so as to connect the hollow space (6), outside the flexible plate (2), to an outer suction source so as to create, within the hollow space (6), a vacuum for suctioning and tightly applying the surface (7) of the tissue (8) against the peripheral bearing means (3); and a hollow contact pad (11) which is placed between the area (4) and the bottom wall (5), which has a recess in the center thereof on the area (4) side and along an axis (10) substantially perpendicular to the bottom wall, and which is arranged so as to be in contact with the area (4) when the vacuum is created in the space (6).

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
• A61M 27/00 - Drainage appliances for wounds, or the like
• A61B 17/30 - Surgical pincettes

Abstract

The invention relates to a triangular patch resonator with a triangle pattern (30), in which the two sides of the triangle that are symmetrical in relation to an axis are associated respectively with an input coupler and an output coupler, comprising slots in the form of three-arm stars, namely: a first slot (41) extending along the aforementioned axis on each side of the centre of the triangle and two other slots (42, 43) extending symmetrically from the base of the first slot, with none of said slots opening out to the exterior. In addition, an adjustable capacitor (51-53) is connected through each of the slots.

IPC Classes  ?

• H01P 7/08 - Strip line resonators

Abstract

The invention relates to a device for processing a fluid, in particular sludge, including: an enclosure (E) delimiting a chamber (C) for the flow of the fluid, and including a longitudinal tubular wall (2) and end walls, at least one transmitting device including a bar (6) which is immersed and extends longitudinally into said chamber, and which is capable of radially generating an ultrasonic vibration, and an arrangement (12) placed in the space between the tubular wall (2) and the bar (6) of the transmitting device and including at least one obstacle (13) which deflects the flow of the fluid, and which has an inner edge located at a distance from the bar in such a manner as to leave at least one inner passage between said inner edge and the bar, said inner passage being placed in the area of a bulge of the radial ultrasonic vibration, in such a manner that the fluid can pass from one side of said obstacle to the other by flowing along the bar, and in correspondence with said bulge of the radial ultrasonic vibration.

IPC Classes  ?

• C02F 11/00 - Treatment of sludge; Devices therefor
• C02F 11/12 - Treatment of sludge; Devices therefor by de-watering, drying or thickening
• C02F 1/36 - Treatment of water, waste water, or sewage with mechanical oscillations ultrasonic vibrations

Abstract

The present invention relates to the use of a peptide comprising the amino acid sequence SEQ ID NO: 1, or of a peptide comprising an amino acid sequence having 93%, especially 95%, in particular 98% sequence identity homology with the sequence SEQ ID NO: 1, for obtaining a transporter intended for the internalization of a molecule of diagnostic or therapeutic interest into target cells.

IPC Classes  ?

• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
• C12N 15/62 - DNA sequences coding for fusion proteins
• A61K 47/42 - Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Abstract

The invention relates to a high-frequency transmission line including a conductive tape (6) associated with a shielding surface (4) that is placed under the line structure and is divided into parallel microstrips in a direction generally orthogonal to the direction of the line, said microstrips being movable relative to the conductive tape.

IPC Classes  ?

• H01P 3/00 - Waveguides; Transmission lines of the waveguide type
• H01P 3/08 - Microstrips; Strip lines

Abstract

The invention relates to the use of isoquinolones for preparing drugs, including novel isoquinolones. The invention also relates to said novel isoquinolones as well as to the method for synthesising same. In particular, the invention relates to isoquinolone derivatives used in the treatment of pathological angiogeneses, specifically cancer.

IPC Classes  ?

• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• C07D 217/22 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
• C07D 217/24 - Oxygen atoms
• C07D 215/233 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
• A61P 35/00 - Antineoplastic agents

Abstract

The use of the IRAP protein for implementing methods of diagnosis and of prognosis.

IPC Classes  ?

• G01N 33/573 - Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device (1) according to the invention comprises: - a sampling tip (2) having a contacting end intended to be introduced into a medium containing said fluid, and - the or each capturing unit which is bound to said end and which comprises a capture substrate (3) defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer (4) designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.

IPC Classes  ?

• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

Abstract

The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.

IPC Classes  ?

• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07C 51/367 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
• C12P 13/04 - Alpha- or beta-amino acids
• C12P 13/06 - Alanine; Leucine; Isoleucine; Serine; Homoserine
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.

IPC Classes  ?

• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07C 51/367 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
• C12P 13/04 - Alpha- or beta-amino acids
• C12P 13/06 - Alanine; Leucine; Isoleucine; Serine; Homoserine
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

The present application relates to the use of miRNAs as biomarkers in glioma diagnosis. The application moreover relates to the use of miRNAs as biomarkers in glioblastoma and oligodendroglioma diagnosis.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

o)≧1. Method for manufacturing a detector fulfilling the above conditions.

IPC Classes  ?

• G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
• G08B 21/00 - Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for

Abstract

The present invention relates to a needle holder device (40) for treating the prostate, involving a series of steps of inserting a needle into the prostate, comprising a rectal probe (2) for ultrasonic 3D imaging and a computer for processing the image acquired by said probe and for computing the position of the needle (3) relative to the prostate. The computer is controlled so as to periodically output information on the movement of the prostate after each of the insertion steps in order to validate the insertion parameters relative to a treatment schedule and, if need be, modifying the insertion parameters relative to said schedule in the event the movement is greater than a threshold value.

IPC Classes  ?

• A61B 17/34 - Trocars; Puncturing needles
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)

Abstract

The present invention finds application in the field of medicine and, in particular, it relates to new compounds for the treatment and/or prevention of HIV; Ebola, Dengue, Hepatitis C, SARS or tuberculosis infections.

IPC Classes  ?

• C07H 15/207 - Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
• A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
• A61P 31/12 - Antivirals

Abstract

The invention relates to a method for grafting compounds onto a material including, on the surface thereof, an element selected from among carbon, silicon, and germanium, said method including the following steps: a) providing a material including, on the surface thereof, sp3 hybridized carbon, silicon, and/or germanium atoms having at least one hydrogen atom, and b) placing the material as provided in step a) in contact, in a solvent, with a compound (C) containing at least one unprotonated amino function, whereby said compound (C) is grafted onto said material.

IPC Classes  ?

• B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
• B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

The tank is of the type including a container (4) for housing hydrogen, and metallic hydride placed inside the container. According to one aspect of the invention, it includes at least one solid body (6) formed of a compacted material including metallic hydride and a matrix. Application in particular for tanks for internal combustion engines or for fuel cells, in particular for motor vehicles, as well as for any stationary or mobile application using hydrogen.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• F17C 11/00 - Use of gas-solvents or gas-sorbents in vessels
• F17C 1/00 - Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge
• C01B 3/00 - Hydrogen; Gaseous mixtures containing hydrogen; Separation of hydrogen from mixtures containing it; Purification of hydrogen

Abstract

The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing said compound; placing the structure (1) in a position such that the surface of the material to be etched is in the presence of the solution and additional bubbles of a gas; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating reactive cavitation bubbles such that the chemical species is generated in the presence of these additional bubbles and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• C23F 1/02 - Local etching

Abstract

The invention relates to a method for assaying the circulating extracellular portion of the IRAP ("insulin-responsive aminopeptidase") protein, including at least one step of quantitatively assaying the released and purified extracellular portion of the IRAP using at least one marked peptide, said marked peptide specifically interacting with said extracellular portion of the IRAP.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing the compound and a powder of particles or solid grains (13) in suspension; placing the material to be etched in the presence of the solution; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating active cavitation bubbles such that the chemical species is generated and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.

IPC Classes  ?

• H01L 21/306 - Chemical or electrical treatment, e.g. electrolytic etching
• H01L 21/311 - Etching the insulating layers
• C23F 1/00 - Etching metallic material by chemical means

Abstract

This invention relates to fertilization modulation compounds and process for implementing them.

IPC Classes  ?

• A61K 38/46 - Hydrolases (3)
• A61P 15/16 - Masculine contraceptives
• A61P 15/18 - Feminine contraceptives

Abstract

The present invention relates to a polypeptide comprising or constituted of the sequence RILAR (SEQ ID NO: 3), the use thereof in imaging methods, in diagnostic or prognostic methods and for use as a medicament.

IPC Classes  ?

• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 49/00 - Preparations for testing in vivo
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention relates to an optical device for the interferometric analysis of the surface condition of an object (2), including: a light source (1); an optical fibre (42) capable of receiving the incident light wave and transmitting said wave to the object (2); a detector (9) capable of detecting a combination between a light wave (45) reflected by the optical fibre and a light wave (46) returned by the object; and in which the optical fibre (42) has a free end in the shape of a cone, with a vertex angle of between 15 and 25 degrees, the tip of the cone having dimensions of less than 50 x 50 nm, and the tip of the cone being placed, while in use, at a distance of between 5 and 50 μm from the surface of the object.

IPC Classes  ?

• G01B 9/02 - Interferometers
• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G01B 21/00 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
• G01B 7/34 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring roughness or irregularity of surfaces

Abstract

The present invention relates to a method and device for controlling a crystallisation using a steam source (10) in an isothermal system (8) to monitor the crystallization or recrystallization of a solid matter sample (9) that is initially at least partially amorphous and/or at least partially crystalline and contained within the system (8), said steam source (10) including at least one solvent for crystallizing said solid matter, the steam diffusion (14) of which causes the crystallization or recrystallization of the sample (9), said steam source (10) being such that the heat exchange amounts within the system during the crystallization or recrystallization of the sample (9) other than the crystallization or recrystallization heat of the sample are less than about 10%, particularly 5%, and advantageously 1% of the crystallization or recrystallization heat of the sample. The steam source (10) is preferably a pure solvent or a solvent mixture in which no solute is dissolved.

IPC Classes  ?

• G01N 25/14 - Investigating or analysing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation

Abstract

A method for processing cardiac signals includes accepting, from a sensor system, a set of one or more signals, the signals including components of a desired cardiac signal and components of a substantially periodic interfering signal. The method is applicable for extraction of desired fetal cardiac signals from signals with interference from the maternal cardiac signal. A periodicity of the interfering signal is determined, and one or more iterations of mitigating an effect of a component of the signals that exhibit periodicity at the determined periodicity of the interfering signal are performed. In some examples, the method further includes determining a periodicity of the desired cardiac signal, and performing one or more iterations of enhancing an effect of a component of the signals that exhibit periodicity at the determined periodicity of the desired cardiac signal.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/0444 - Foetal cardiography
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

The device is characterized in that it comprises, in combination, a horizontal circular support plate (1) for animals (2), rotated about a vertical axis (3), a cylindrical wall (4) the outside diameter of which is approximately the same as that of the rotating plate (1), this wall delimiting an internal confining space (7) forming a cage for housing the animals moving freely on the plate, a fixed intermediate partition (12) extending inside the cylindrical wall (4) and dividing the internal confining space into two opposed compartments (13, 14), an upper closing lid (15), which is preferably removable, secured to the intermediate partition (12) and extending parallel to the plate (1), and a system (36) for supplying breathing gas through the closing lid (15) for the animals (2) present in the two opposed compartments (13, 14) of the confining space (7).

IPC Classes  ?

• G09B 23/36 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for zoology

Abstract

The invention relates to a heat exchange structure that comprises a main surface (6) provided with blind holes (8) formed in said surface (6), the inner surface of the holes (8) and the surface (10) of said main surface outside the holes being covered with nanoparticles (12), the inside of the holes (8) having a non-wettability property relative to a given liquid, and the surface (10) of the surface between the holes (8) having a wettability property relative to said liquid.

IPC Classes  ?

• H01L 23/373 - Cooling facilitated by selection of materials for the device
• H01L 23/427 - Cooling by change of state, e.g. use of heat pipes
• H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
• F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure
• F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing

Abstract

The present invention relates to the use of at least one glucose derivative, halogenated in the 6-position, for implementing a method for determining the insulin resistance in a mammal, in particular a human, by measuring - the variation in the amount (as a function of time) of the abovementioned derivative, in muscle cells, for a given period Δt, after administration of the abovementioned derivative, and - the variation in the amount (as a function of time) of the abovementioned derivative, in the abovementioned muscle cells, for a period substantially equal to the abovementioned period Δt, after administration of the abovementioned derivative, preceded by an administration of insulin.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 51/04 - Organic compounds
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

The present invention relates to an NS5B protein of the hepatitis C virus (HCV), efficient for replication, which carries a point mutation in at least one of the following positions: - at the position corresponding to residue 262 of SEQ ID NO: 1; and/or - at the position corresponding to residue 265 of SEQ ID NO: 1; and/or - at the position corresponding to residue 316 of SEQ ID NO: 1.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C07K 14/18 - Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus

Abstract

The invention relates to the use of the IRAP protein for implementing methods of diagnosis and of prognosis.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The present invention relates to the use of a hybrid protein comprising the sequence of a first membrane receptor fused at its C-terminus to the N-terminus of an ion channel, and possibly containing a linker between the C-terminus of said first membrane receptor and the N-terminus part of said ion channel, said linker being absent in the natural configuration of said first membrane receptor and said ion channel, as a biosensor for: the screening of drugs modulating the activity of said first membrane receptor in its natural configuration, and/or for the in vitro diagnosis of pathologies associated with the presence or the variation of amount of a molecule modifying the activity of said first membrane receptor in its natural configuration.

IPC Classes  ?

• C07K 14/715 - Receptors; Cell surface antigens; Cell surface determinants for interferons
• C07K 14/72 - Receptors; Cell surface antigens; Cell surface determinants for hormones
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present invention relates to the preparation of oligonucleotides comprising a 5’-phosphate monoester end.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

The invention relates to a battery (10) that includes first and second chambers (14A, 14B) containing a solvent and separated by a wall (16) permeable to said solvent and impermeable to hydroxyl and/or hydronium ions, a first electrode (18A) provided in the first chamber, a second electrode (18B) provided in the second chamber. A first redox pair includes a first oxidiser and a first reducer involved in first oxidation-reduction reactions leading to an electron exchange with the first electrode. A second redox pair includes a second oxidiser and a second reducer involved in second oxidation-reduction reactions leading to an electron exchange with the second electrode. The wall is impervious to the first and second redox pairs. First enzymes or first micro-organisms are provided in the first or second chamber, and promote third oxidation-reduction reactions leading to the conversion of a first substance in order to produce a second substance containing basic or acidic species in the solvent of the first and/or second chamber.

IPC Classes  ?

• H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• H01M 8/20 - Indirect fuel cells, e.g. fuel cells with redox couple being irreversible

Abstract

The invention relates to a device for positioning a moveable object (1) which can be moved over a distance of the order of 1 nanometre in a time of 1 microsecond or less, comprising: a microtip (6); first piezoelectric positioning, polarization, detection and control means (8, 10) for moving the microtip relative to the object and bringing it to a distance of the order of 1 nanometre from the object, in order to make a tunnel current flow between the microtip and the object, for measuring the tunnel current and for slaving, depending on the measured tunnel current, the distance between the microtip and the object to a constant value (dref); and second positioning and control means (4, 10) which are capacitively coupled to the object so as to oppose an attractive force between the object and the microtip depending on the measured tunnel current, the second means being tied to a reference plane (3).

IPC Classes  ?

• G01P 15/08 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values
• G01P 15/13 - Measuring acceleration; Measuring deceleration; Measuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values by measuring the force required to restore a proofmass subjected to inertial forces to a null position
• G01Q 10/06 - Circuits or algorithms therefor
• G01Q 60/10 - STM [Scanning Tunnelling Microscopy] or apparatus therefor, e.g. STM probes

Abstract

The invention relates to the use of one element chosen among a nucleic acid molecule, a fragment of said nucleic acid molecule and a variant of the said nucleic acid molecule for the in vitro or ex vivo diagnosis of any type of somatic or ovarian cancers, wherein at least one of any of the above described elements is abnormally expressed in cancer cells of at least one type of the somatic or ovarian cancers, and wherein each type of somatic or ovarian cancer cells abnormally expresses at least one of the above described elements.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a capacitive detector and device for measuring the detector integral, including: a ribbon in a dielectric material (2), first and second electrodes (4, 5) shaped like combs and formed on a first surface of said ribbon, and a third electrode formed on the other surface of said ribbon and facing said first and second electrodes; the thickness (e) of the dielectric ribbon (2) is less than or equal to said predetermined period (λ) divided by four times pi, or λ/4π≥e; and the relationship resulting from division, in the numerator, of the capacity (C) between two adjacent branches (9, 11) of said first and second electrodes in the presence of at least one fluid having dielectric permittivity (εf) and, in the denominator, by the dielectric permittivity (εf) of the fluid multiplied by the capacity (Co) between the two adjacent branches of the first and second electrodes in the presence of the void is greater than or equal to one, or C/εf.Co≥ l. The invention further relates to a method for manufacturing a detector respecting the above conditions.

IPC Classes  ?

• G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields