CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Larrat, Sylvie, Jacqueline, Henriette
Tremeaux, Pauline
Santoni, Elodie
Thelu, Marie-Ange
Abrégé
The present invention relates to methods for amplifying and sequencing the full-length genome of a hepatitis C vims. The present invention also relates to primers and kits for amplifying and sequencing the full-length genome of a hepatitis C virus.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
2.
Process for the manufacture of a component comprising a stack of a functional layer on a composite film
Commissariat a L'Energie Atomique et aux Energies Alternatives (France)
Centre National de la Recherche Scientifique (France)
Universite Joseph Fourier (France)
Inventeur(s)
Viala, Bernard
Takacs, Helene
Tortai, Jean-Herve
Abrégé
A process of manufacturing component with a composite film including a matrix made of thermoplastic polymer and particles inside this matrix. This process includes heating the composite film in order for its temperature to exceed the glass transition temperature of its matrix, then when the composite film is softened, flattening an external face of the composite film by a smooth face resting directly over the whole of this external face, this smooth face forming part of the front face of a flexible membrane, the whole of the rear face of which, located on the side opposite the front face, is pushed against the composite film by a fluid, then cooling the composite film below the glass transition temperature, then withdrawing the membrane in order to mechanically separate its front face from the external face of the composite film.
B05D 3/12 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliqués; Traitement ultérieur des revêtements appliqués, p.ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par des moyens mécaniques
B32B 33/00 - Produits stratifiés caractérisés par des propriétés particulières ou des caractéristiques de surface particulières, p.ex. par des revêtements de surface particuliers; Produits stratifiés conçus pour des buts particuliers non couverts par une seule autre classe
B32B 37/10 - Procédés ou dispositifs pour la stratification, p.ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par la technique de pressage, p.ex. faisant usage de l'action directe du vide ou d'un fluide sous pression
B05D 5/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
B29C 70/58 - Façonnage de matières composites, c. à d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p.ex. des inserts comprenant uniquement des matières de remplissage
B29C 70/88 - Façonnage de matières composites, c. à d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p.ex. des inserts caractérisées principalement par des propriétés spécifiques, p.ex. électriquement conductrices ou renforcées localement
B30B 5/02 - Presses caractérisées par l'emploi d'organes de pression autres que ceux mentionnés dans les groupes et dans lesquels les organes de pression se présentent sous forme d'un élément flexible, mis en action par la pression d'un fluide, p.ex. un diaphragme
B32B 37/00 - Procédés ou dispositifs pour la stratification, p.ex. par polymérisation ou par liaison à l'aide d'ultrasons
B32B 7/02 - Propriétés physiques, chimiques ou physicochimiques
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
B32B 27/18 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers
B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
B32B 27/34 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyamides
B32B 27/36 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyesters
3.
Coverage guided technique for bug finding in control systems and software
A computer-implemented method for automatically identifying a faulty behavior of a control system. The method includes receiving, at a test processor, a description of the faulty behavior. The method also includes selecting, using the test processor, a goal state based on a heuristic decision. The method also includes selecting, using the test processor, a selected system state. The method also includes selecting, using the test processor, a selected variable to the control system based on the goal state. The method also includes loading, from a memory, a control model of the control system. The method also includes performing, using the test processor, a simulation of the control model using the selected variable and the selected system state as parameters of the simulation. The method also includes determining, using the test processor, whether the faulty behavior was observed based on the simulation.
The invention relates to a composition comprising all or part of the aleurone layer of a cereal for the use thereof in the prevention or treatment of alterations induced by at least one pollutant, especially contained in a food.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Posseme, Nicolas
Joubert, Olivier
Vallier, Laurent
Abrégé
A microelectronic method for etching a layer to be etched, including: modifying the layer to be etched from a surface of the layer to be etched and over a depth corresponding to at least a portion of thickness of the layer to be etched to form a film, with the modifying including implanting light ions into the layer to be etched; and removing the film includes a selective etching of the film relative to at least one layer underlying the film.
H01L 21/302 - Traitement des corps semi-conducteurs en utilisant des procédés ou des appareils non couverts par les groupes pour changer leurs caractéristiques physiques de surface ou leur forme, p.ex. gravure, polissage, découpage
H01L 21/306 - Traitement chimique ou électrique, p.ex. gravure électrolytique
H01L 21/3213 - Gravure physique ou chimique des couches, p.ex. pour produire une couche avec une configuration donnée à partir d'une couche étendue déposée au préalable
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
H01L 21/266 - Bombardement par des radiations ondulatoires ou corpusculaires par des radiations d'énergie élevée produisant une implantation d'ions en utilisant des masques
6.
METHOD FOR THE AUTOMATED MANUFACTURE OF AN ELECTRONIC CIRCUIT SUITABLE FOR DETECTING OR MASKING FAULTS BY TEMPORAL REDUNDANCY, AND ASSOCIATED COMPUTER PROGRAMME AND ELECTRONIC CIRCUIT
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Fradet, Pascal
Burlyaev, Dmitry
Girault, Alain
Abrégé
A method for the automated manufacture of an electronic circuit tolerant to faults by temporal redundancy of maximum order N, comprising a step implemented by computer, which involves replacing any memory cell of the circuit with a memory block (40) comprising a chain of memory cells in series, and a selection block which selects, in a temporal redundancy mode of order n1, n1 ∈ [1,N], as output data of the memory block, the majority content of n1 cells of the block, and can further deliver a fault signal if the content of the n1 cells differs. Said method is characterised in that the inserted memory blocks allow dynamic switching from a temporal redundancy mode of order n1 to any other mode of order n2. Said method for N=2, in association with a recording mechanism with backward recovery, makes it possible to mask an error with only double redundancy instead of triple redundancy.
The invention relates to a bioreactor obtained by compression of a mixture comprising an enzyme and a conductor, the inactive surfaces of the bioreactor being coated with impermeable parylene (32), and each active surface of the bioreactor being coated with a nano-porous membrane of parylene (40) glued along the periphery thereof.
H01M 8/16 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible biochimique, c. à d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
C12N 9/00 - Enzymes, p.ex. ligases (6.); Proenzymes; Compositions les contenant; Procédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
H01M 4/86 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes inertes ayant une activité catalytique, p.ex. pour piles à combustible
8.
MEASUREMENT DEVICE FOR CORRECTING PARASITIC MOVEMENTS IN AN X-RAY TOMOGRAPH
The invention concerns a device for measuring parasitic movements in a sample (5) to be analysed in an X-ray tomography apparatus, the device comprising: a source (1) emitting an X-ray beam (6) to a detector (3), the sample, carried by a support (13), being traversed by the beam; and a sight (17) carrying at least three balls (21) that are opaque to X-rays, the sight being attached to said support such that, on the detector, images (25) of the balls are around an image (16) of the sample, the shape and the materials of the sight being chosen such that the positions of the balls relative to the support are insensitive to temperature variations.
G01N 23/04 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p.ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux
9.
METHOD FOR THE RADIO COMMUNICATION OF DIGITAL DATA IN A NOISY ENVIRONMENT
The invention relates to a device for the radio transmission of a data word between a transmitter (1) and a receiver (65), comprising a transmitter (1) that can transmit at least one block of data comprising a preamble word and a data word repeated several times; an elementary synchronisation block allowing the synchronisation of the receiver (65) to the transmitter (1) and the detection of the preamble word; and a synchronous averaging device (67) calculating the average of the data word repeated.
The invention concerns a bioreactor obtained by compressing a mixture of an enzyme, a conductor and chitosan. The conductor can consist of carbon nanotubes. This bioreactor can be produced according to the following steps: preparing a mixture of powders in which the proportion of enzyme powder relative to a carbon nanotube powder is of the order of 50/50 by weight; preparing a viscous solution of chitosan in a ratio of 5 to 15 (in mg) of chitosan to 0.75 to 1.25 (in ml) of acetic acid diluted to 0.4 to 0.6 % by volume in water; adding the viscous chitosan to the mixture of powders in a proportion be weight of 3 to 5 of powder to 5 to 10 of chitosan; carrying out a first compression followed by light grinding; carrying out a second compression to produce a pellet; and drying at ambient temperature.
H01M 4/86 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes inertes ayant une activité catalytique, p.ex. pour piles à combustible
H01M 4/90 - Emploi de matériau catalytique spécifié
H01M 8/16 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible biochimique, c. à d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
11.
NOVEL LECTINS AND APPLICATIONS FOR THE DETECTION OF PATHOLOGICAL STATE MARKERS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS (France)
UNIVERSITÉ JOSEPH FOURIER (France)
Inventeur(s)
Imberty, Anne
Audfray, Aymeric
Arnaud, Julie
Abrégé
Multimenic lectins having a β-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
Centre National de la Recherche Scientifique (France)
Univeriste Joseph Fourier (France)
Inventeur(s)
Trinh, Hieu
Rouger, Nicolas
Crebier, Jean-Christophe
Lembeye, Yves
Abrégé
The invention relates to a voltage converter (100), including: a plurality of two-way conversion cells (303), each cell comprising a primary circuit (307, Wp), and a secondary circuit (308, Ws) that is insulated from the primary circuit, wherein each circuit can be separately activated in order to supply an output voltage from the converter; and at least one control circuit (306) configured to, in a first operating mode, control the activated cells in order to transfer electrical energy from the primary circuit to the secondary circuit, and control the inactivated cells in order to transfer electrical energy from the secondary circuit to the primary circuit.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 1/36 - Moyens pour mettre en marche ou arrêter les convertisseurs
H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation
13.
METHOD FOR THE IN VITRO DETECTION OF STRAINS OF LEGIONELLA PNEUMOPHILA RESISTANT TO ANTIBIOTICS
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Maurin, Max, Maurin, Louis
Schneider, Dominique
Shadoud, Lubana
Jarraud, Sophie
Timsit, Jean François
Etienne, Jérôme
Abrégé
The invention relates to a method for the in vitro detection of strains of Legionella pneumophila that are resistant to antibiotics, especially fluoroquinolones. The invention also relates to nucleotide probes and to a kit of reagents allowing the detection of bacterial strains of Legionella pneumophila that are resistant to antibiotics, especially of the fluoroquinolone type.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (France)
Inventeur(s)
Favier, Denis
Mozer, Pierre
Payan, Yohan
Antherieu, Gabriel
Connesson, Nathanael
Abrégé
The invention concerns a spacer (300) comprising a first part (321) made from a first shape memory material, and a second part (323) made from a second shape memory material.
A61F 2/88 - Stents ayant une forme caractérisée par des éléments filiformes; Stents ayant une forme caractérisée par une structure de type filet ou de type à mailles les éléments filiformes étant sous forme d’enroulements hélicoïdaux ou en spirale
15.
HEAT EXCHANGE STRUCTURE, METHOD FOR PRODUCING SAME, HEAT EXCHANGE DEVICE COMPRISING SUCH A STRUCTURE AND USES OF SAME
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gruss, Jean-Antoine
Bertossi, Rémi
Caney, Nadia
Marty, Philippe
Poncelet, Olivier
Voirand, Antoine
Abrégé
The present invention relates to a heat exchange structure implementing heat transfer by boiling a liquid and comprising a substrate and at least one layer intended to be in contact with a liquid and disposed at least partially on the substrate. The composition of this layer comprises at least one molecular switch having a lower critical solution temperature TLCST above which it gives the layer non-wetting properties with regard to the liquid and below which it gives the layer wetting properties with regard to the liquid, said lower critical solution temperature TLCST of the molecular switch being chosen so as to be greater than or equal to the saturation temperature Tsat of the liquid. The present invention also relates to an assembly and to a heat exchange device comprising such a structure, to the uses of same and to the methods for producing such a structure and assembly.
F28F 13/18 - Dispositions pour modifier le transfert de chaleur, p.ex. accroissement, diminution par application d'un traitement de surface, p.ex. un polissage
A method for processing cardiac signals includes accepting, from a sensor system, a set of one or more signals, the signals including components of a desired cardiac signal and components of a substantially periodic interfering signal. The method is applicable for extraction of desired fetal cardiac signals from signals with interference from the maternal cardiac signal. A periodicity of the interfering signal is determined, and one or more iterations of mitigating an effect of a component of the signals that exhibit periodicity at the determined periodicity of the interfering signal are performed. In some examples, the method further includes determining a periodicity of the desired cardiac signal, and performing one or more iterations of enhancing an effect of a component of the signals that exhibit periodicity at the determined periodicity of the desired cardiac signal.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Pelletier, Jacques
Ponard, Pascal
Lacoste, Ana
Bes, Alexandre
Regnard, Guillaume
Darges, Bernard
Peillex-Delphe, Guy
Abrégé
The invention concerns a plasma generator in a vacuum chamber comprising at least one elementary generator opening into the chamber, the elementary generator comprising: - a microwave generator, - an impedance adapter extending in a coaxial direction, the adapter being configured to adapt the impedance of the plasma to the impedance of the microwave generator and to protect the microwave generator, the microwave generator being located in the extension of the adapter and connected directly to the adapter.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Arnoud, Yannick
Guillaudin, Olivier
Abrégé
The invention relates to a matrix device for measuring characteristics of an X-ray beam. Said device includes a first set (32) of detection cells of a size different from the cells of at least one second set (33, 34) of detection cells. Each cell corresponds to an ionization chamber including a detection electrode. The detection electrodes of all the cells have the same effective surface for collecting charges.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p.ex. sur la position ou la section du faisceau; Mesure de la distribution spatiale de radiations
19.
METHOD FOR PRODUCING A SCHOTTKY DIODE ON A DIAMOND SUBSTRATE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
INSTITUT POLYTECHNIQUE DE GRENOBLE (France)
Inventeur(s)
Eon, David
Gheeraert, Etienne
Muret, Pierre
Pernot, Julien
Traore, Aboulaye
Abrégé
The invention relates to a method for producing a Schottky diode, comprising the following steps: a) oxygenating the surface of a semiconductive layer (105) of monocrystalline diamond, in such a way as to replace hydrogen surface terminations of the semiconductive layer (105) with oxygen surface terminations; and b) forming, by physical vapour deposition, a first conductive layer of zirconium or indium-tin oxide on the surface of the semiconductive layer (105).
H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Cosnier, Serge
Holzinger, Michael
Le Goff, Alan
Agnes, Charles
Abrégé
The invention relates to a supercapacitor (10) to be submerged in a medium (15) containing a biological material and an oxidant, wherein the anode (A) comprises a first enzyme that can catalyse the oxidation of the biological material and the cathode (K) comprises a second enzyme that can catalyse the reduction of the oxidant, and wherein each of the anode and cathode electrodes consists of a solid agglomerate of a conductive material mixed with the first or the second enzyme, said agglomerate having a specific surface that is larger than or equal to 20 m2/g and an average pore size varying between 0.7 nm and 10 pm.
H01G 11/36 - Nanostructures, p.ex. nanofibres, nanotubes ou fullerènes
H01G 11/62 - Condensateurs hybrides, c. à d. ayant des électrodes positive et négative différentes; Condensateurs électriques à double couche [EDL]; Procédés de fabrication desdits condensateurs ou de leurs composants Électrolytes Électrolytes liquides caractérisés par le soluté, p.ex. sels, anions ou cations
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Perraud, Simon
Berger, François
Gaillard, Frédéric
Karst, Nicolas
Pantigny, Philippe
Rouviere, Emmanuelle
Abrégé
The invention relates to an implantable energy source comprising at least one energy storage sub-system (171) constructed in the form of a stack of thin layers (175) on a substrate (176), characterised in that said energy storage sub-system has a plurality of through-openings (174) for allowing the development and the passage of blood vessels. Preferably, the energy source thereof has a thickness of less than, or equal to, 1 mm, over at least 80% of its surface.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Posseme, Nicolas
Joubert, Olivier
Vallier, Laurent
Abrégé
The invention relates to a microelectronic method for etching a layer to be etched, comprising the following steps: - modifying the layer to be etched from the surface of the layer to be etched and over a depth corresponding to at least a portion of the thickness of the layer to be etched so as to form a film, the modification comprising implanting light ions in the layer to be etched; - removing the film comprising a selective etching of the film relative to at least one layer underlying the film.
H01L 21/3213 - Gravure physique ou chimique des couches, p.ex. pour produire une couche avec une configuration donnée à partir d'une couche étendue déposée au préalable
23.
Method for removing a part made of a material having a glass-transition temperature from a mold
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Gravier, Sébastien
Kapelski, Georges
Blandin, Jean-Jacques
Josserond, Charles
Abrégé
A method for removing a part from a mold and to a machine for molding the part, the part made of a material having a glass-transition temperature and a melting temperature that is higher than the glass-transition temperature, and which is shaped in the cavity of a mold, includes at least two mold portions defining the shaping cavity therebetween. The mold is at a temperature between the glass-transition temperature and the melting temperature. The method includes opening the mold by spacing apart the mold portions, locally spraying a cooling gas toward the part remaining in a portion of the mold using at least one nozzle, and, after a predetermined time period following the start of spraying the gas, ejecting the part from the portion of the mold, the time period being such that the part reaches a temperature that is lower than the glass-transition temperature thereof.
B22D 17/22 - Moules métalliques; Plaques de moules; Supports de moules; Equipement de refroidissement des moules; Accessoires pour l'extraction et l'éjection des pièces hors du moule
B22D 25/06 - Coulée particulière caractérisée par la nature du produit par ses propriétés physiques
B22D 27/04 - Action sur la température du métal, p.ex. par chauffage ou refroidissement du moule
B22D 29/00 - Extraction des pièces hors du moule, non limitée à un procédé de coulée couvert par un seul groupe principal; Extraction des noyaux; Manipulation des lingots
B22D 30/00 - Refroidissement des pièces coulées, non limité à des procédés de coulée couverts par un seul groupe principal
24.
SYSTEM FOR THE REVERSIBLE STORAGE OF HYDROGEN IN A MATERIAL IN THE FORM OF A METAL HYDRIDE COMPRISING A PLURALITY OF HEAT PIPES IN THERMAL CONTACT WITH THE MATERIAL
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (France)
UNIVERSITE JOSEPH FOURIER (France)
D.A.T.E. (DEVELOPPEMENT ET APPLICATION DES TECHNIQUES DE L'ENERGIE) (France)
Inventeur(s)
De Rango, Patricia
Marty, Philippe
Delhomme, Baptiste
Moracchioli, Robert
Nachev, Simeon
Abrégé
System (3) for the reversible storage of hydrogen, comprising: at least one reservoir (9) comprising a material (11) for storing hydrogen by absorption in the form of a metal hydride and for releasing hydrogen from storage by desorption; and at least one device (13) in thermal contact with the material in order, on the one hand, to extract heat from the material while the hydrogen is being absorbed, the device being intended to be in thermal contact with a cold source (7) receiving the extracted heat and, on the other hand, to supply heat to the material during the desorption of the hydrogen, the device being intended to be in thermal contact with a hot source (5) supplying the added heat. The device comprises a plurality of heat pipes (41-43-45) for transporting at least a fraction of the added heat and/or for transporting at least a fraction of the extracted heat. Assembly comprising such a system and a hot source and a cold source both in thermal contact with the device.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gentile, Pascal
Sadki, Saïd
Thissandier, Fleur
Hadji, Emmanuel
Abrégé
The invention relates to an electrode, to the method for manufacturing same and to a device for storing and delivering electric power including same. The electrode of the invention includes a mounting, made of a conductor or semiconductor material, said mounting including, on at least one of the surfaces thereof, at least one nanostructure made of a semiconductor material, characterised by also including a protective layer made of a material selected among a dielectric material having an intrinsic capacity of 1.5 10-6 to 10 10-6 F/cm2 and a metal, said layer having a thickness that is less than the height of said nanostructure, and covering the at least one nanostructure. The invention is useful in the field of electrochemical storage and, in particular, in the field of ultracapacitors.
H01G 11/24 - Condensateurs hybrides, c. à d. ayant des électrodes positive et négative différentes; Condensateurs électriques à double couche [EDL]; Procédés de fabrication desdits condensateurs ou de leurs composants Électrodes caractérisées par les propriétés structurelles des poudres ou particules utilisées à cet effet
H01G 11/30 - Condensateurs hybrides, c. à d. ayant des électrodes positive et négative différentes; Condensateurs électriques à double couche [EDL]; Procédés de fabrication desdits condensateurs ou de leurs composants Électrodes caractérisées par leur matériau
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
H01M 4/134 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif Électrodes pour accumulateurs à électrolyte non aqueux, p.ex. pour accumulateurs au lithium; Leurs procédés de fabrication Électrodes à base de métaux, de Si ou d'alliages
The invention relates to a radiofrequency propagation line including a conducting strip (31) connected to a conducting plane (37) parallel to the plane of the conducting strip, wherein the conducting plane includes a network of nanowires (36) made of an electrically conductive, non-magnetic material extending orthogonally to the plane of the conducting strip, in the direction of said conducting strip.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Cremillieux, Yannick
Bianchi, Andrea
Dufort, Sandrine
Coll, Jean-Luc
Lux, François
Tillement, Olivier
Abrégé
The invention relates to a novel use of ultrafine nanoparticles, which are of use as a diagnostic, therapeutic or theranostic agent, characterized by the mode of administration thereof via the airways. The invention is also directed towards the uses which follow from this new mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of lung diseases. In the therapeutic field, the uses envisaged are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), for neutron therapy, and of agents for PDT (photodynamic therapy), in particular for treating lung tumours.
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM) caractérisées par un aspect physique particulier, p.ex. émulsions, microcapsules, liposomes
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p.ex. émulsion, microcapsules, liposomes
Commissariat A L'Energie Atomique Et Aux Energies Alternatives (France)
Universite Joseph Fourier (France)
Inventeur(s)
Delangle, Pascale
Pujol, Anaïs
Dumy, Pascal
Renaudet, Olivier
Ferrand, Michel
Abrégé
The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Trinh, Hieu
Rouger, Nicolas
Crebier, Jean-Christophe
Lembeye, Yves
Abrégé
The invention relates to a voltage converter (100), including: a plurality of two-way conversion cells (303), each cell comprising a primary circuit (307, Wp), and a secondary circuit (308, Ws) that is insulated from the primary circuit, wherein each circuit can be separately activated in order to supply an output voltage from the converter; and at least one control circuit (306) configured to, in a first operating mode, control the activated cells in order to transfer electrical energy from the primary circuit to the secondary circuit, and control the inactivated cells in order to transfer electrical energy from the secondary circuit to the primary circuit.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 1/36 - Moyens pour mettre en marche ou arrêter les convertisseurs
H02M 1/00 - APPAREILS POUR LA TRANSFORMATION DE COURANT ALTERNATIF EN COURANT ALTERNATIF, DE COURANT ALTERNATIF EN COURANT CONTINU OU VICE VERSA OU DE COURANT CONTINU EN COURANT CONTINU ET EMPLOYÉS AVEC LES RÉSEAUX DE DISTRIBUTION D'ÉNERGIE OU DES SYSTÈMES D'ALI; TRANSFORMATION D'UNE PUISSANCE D'ENTRÉE EN COURANT CONTINU OU COURANT ALTERNATIF EN UNE PUISSANCE DE SORTIE DE CHOC; LEUR COMMANDE OU RÉGULATION - Détails d'appareils pour transformation
30.
PYRROLIC DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND THEIR USES AS A DRUG
C07D 207/333 - Radicaux substitués par des atomes d'oxygène ou de soufre
C07D 405/06 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 409/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p.ex. cromakalim
A device for crystallizing a molecule to be crystallized, which includes: at least one crystallization cell that includes a crystallization chamber for receiving a first solution S1 containing the molecule to be crystallized and the crystal seeds thereof, a dialysis membrane, and a container to be filled with a second solution S2 that contains constituents selected from the group containing crystallization agents, additives and buffers; and at least one image acquisition means. The crystallization device is characterized in that it includes: at least one addition means arranged to add, to the container, constituents selected from the group containing crystallization agents, additives and buffers of solution S2; and/or at least one sampling means arranged to collect, from the container, all or a portion of solution S2. The invention also relates to a crystallization method.
C30B 7/08 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p.ex. à partir de solutions aqueuses par refroidissement de la solution
C30B 7/00 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p.ex. à partir de solutions aqueuses
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Chicot, Gauthier
Marechal, Aurélien
Muret, Pierre
Pernot, Julien
Abrégé
The invention relates to a method for producing a component comprising a conductive grid (9) insulated from a semiconductor monocrystalline diamond substrate (2) by an insulating region (7), comprising the following steps: a) oxygenating the surface of the substrate (2) so as to replace the hydrogen surface terminations of the substrate with oxygen surface terminations; and b) forming the insulating region (7) on the surface of the substrate (2) by repeated monatomic layer deposition (ALD).
H01L 21/28 - Fabrication des électrodes sur les corps semi-conducteurs par emploi de procédés ou d'appareils non couverts par les groupes
H01L 29/51 - Matériaux isolants associés à ces électrodes
H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
The present invention relates to a protein complex isolated from its natural environment and comprising the ZEBRA protein of sequence SEQ ID NO: 1, said isolated protein complex having the following properties: - it is more stable than the ZEBRA protein, in particular it is more resistant to the action of proteases than the ZEBRA protein, - it is capable of specifically binding the AZ125 and AZ130 monoclonal antibodies, - it is soluble in a biological fluid, and in particular in a biological fluid chosen from the group consisting of blood and serum, and to the method for demonstrating said complex and the uses of this method for the prognosis or diagnosis of lymphoproliferative episodes associated with EBV.
C07K 16/08 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gans, Pierre
Boisbouvier, Jérôme
Ayala, Isabel
Hamelin, Olivier
Abrégé
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p.ex. glutathion
C07C 59/215 - Composés saturés ne comportant qu'un groupe carboxyle et contenant des groupes cétone contenant des groupes avec de l'oxygène lié par liaison simple
The invention relates to a device for measuring an atomic force, comprising a beam (1) whereof a first end carries a microtip (2); a microtip position sensor (6); means (4) of moving the second end of the beam in the axis z of the microtip; a low-frequency servo loop (13) using a signal (11) of the detector and acting on the means of moving to keep the microtip fixed when the force applied to the microtip varies; whereby the variation in force, ΔF, is given by the expression ΔF = k Δz, where k designates the stiffness of the beam and Δz the movement of the means of moving.
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Jalaguier, Eric
Buckley, Julien
Chevalier, Xavier
Royal, Guy
Abrégé
The invention relates to a method for functionalizing an electrically conductive substrate, which is not a substrate made of gold, via a layer of chemical compounds, said method comprising the following steps: - a step in which the electrically conductive substrate is placed in contact with chemical compounds comprising at least a disulfide terminal group; - a step in which the disulfide terminal group of said chemical compounds is electro-oxidized, causing said chemical compounds to form a layer at the surface of the electrically conductive substrate.
B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion
B05D 3/14 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliqués; Traitement ultérieur des revêtements appliqués, p.ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par des moyens électriques
C07D 257/00 - Composés hétérocycliques contenant des cycles comportant quatre atomes d'azote comme uniques hétéro-atomes du cycle
C07D 339/00 - Composés hétérocycliques contenant des cycles comportant deux atomes de soufre comme uniques hétéro-atomes du cycle
G11B 9/00 - Enregistrement ou reproduction par un procédé ou des moyens non couverts par un des groupes principaux ; Supports d'enregistrement correspondants
G11C 11/00 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants
C07D 409/00 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle
37.
OPTICAL DEVICE FOR INTERFEROMETRIC ANALYSIS OF THE CONDITION OF THE INTERNAL SURFACE OF A TUBE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Chevrier, Joël
Huant, Serge
Abrégé
The invention relates to an optical device for the interferometric analysis of the condition of the internal surface of a tube (11). The device comprises an optical fibre (3), the free end of which is pointed and then bevelled at the single core thereof and the bevelled surface is metallised (10), such that only part of the surface of the fibre core participates in reflecting the incident beam perpendicularly to the axis of the fibre.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Balland, Martial
Mandal, Kalpana
Bureau, Lionel
Abrégé
The present invention relates to an adhesion substrate for at least one animal or human cell, at the surface of which an adhesion unit for at least one animal or human cell is created, said unit comprising at least two zones which adhere to said cell, which are spaced apart by a zone which does not adhere to said cell, on which a polymer which does not adhere to said cell is immobilized, characterized in that the polymer is selected so as to exhibit a conformation which can be modified by variation of a parameter of the environment in which the substrate is situated, to a method for preparing such a substrate and to the cell analysis methods using such a substrate.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
39.
BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/4045 - Indole-alkylamines; Leurs amides, p.ex. sérotonine, mélatonine
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
De Waard, Michel
Abrégé
The invention relates to small cell penetrating peptides (CPP) derived from the scorpion toxin maurocalcine and to their use as vectors for the intracellular delivery of various drugs and agents.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Gravier, Sébastien
Kapelski, Georges
Blandin, Jean-Jacques
Josserond, Charles
Abrégé
The invention relates to a method for removing a part from a mold and to a machine for molding said part, which is in particular made of a material having a glass-transition temperature and a melting temperature that is higher than the glass-transition temperature, and which is shaped in the cavity of a mold including at least two mold portions (3, 4) defining said shaping cavity (5) therebetween, wherein the mold is at a temperature between said glass-transition temperature and said melting temperature, and wherein the method comprises: opening the mold by spacing apart said mold portions (3, 4); locally spraying a cooling gas toward the part remaining in a portion of the mold using at least one nozzle (9); and, after a predetermined time period following the start of spraying the gas, ejecting the part from said portion of the mold, the time period being such that the part reaches a temperature that is lower than the glass-transition temperature thereof.
B22D 17/22 - Moules métalliques; Plaques de moules; Supports de moules; Equipement de refroidissement des moules; Accessoires pour l'extraction et l'éjection des pièces hors du moule
B22D 27/04 - Action sur la température du métal, p.ex. par chauffage ou refroidissement du moule
B22D 29/00 - Extraction des pièces hors du moule, non limitée à un procédé de coulée couvert par un seul groupe principal; Extraction des noyaux; Manipulation des lingots
B22D 30/00 - Refroidissement des pièces coulées, non limité à des procédés de coulée couverts par un seul groupe principal
43.
ANTI-VE-CADHERIN AUTOANTIBODIES AS A BIOMARKER OF VASCULAR ALTERATIONS ASSOCIATED WITH DISORDERS
INSERM (Institut National de la Santé et de la Recherche Médicale) (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
UNIVERSITÉ JOSEPH FOURNIER (France)
Inventeur(s)
Vilgrain, Isabelle
Gulino-Debrac, Danielle
Bouillet, Laurence
Abrégé
The present invention relates to a method for predicting and/or diagnosing vascular alterations associated with a disorder in a patient, comprising a step of detecting or quantifying the presence of anti-VE-cadherin autoantibodies in a biological sample obtained from said patient as well as a kit suitable for carrying out such method.
G01N 33/564 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes
44.
GRAFTED DINUCLEAR METAL COMPLEXES, AND USE THEREOF AS CELLULAR MICROPARTICLE SENSORS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE DE CAEN BASSE-NORMANDIE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Belle, Catherine
Gellon, Gisèle
Plawinski, Laurent
Doeuvre, Loïc
Angles Cano, Eduardo
Abrégé
The invention relates to novel grafted dinuclear metal complexes of formula (I) or of formula (II) in which M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterizing cellular microparticles.
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
45.
METHOD AND DEVICE FOR FORMING METALLIC-GLASS BEADS
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Gravier, Sébastien
Kapelski, Georges
Blandin, Jean-Jacques
Josserond, Charles
Abrégé
The invention relates to a method and a device for forming metallic-glass beads from a metal alloy. The metal alloy, heated in a crucible (7) to a temperature at least equal to the melting point thereof, is extruded through at least one extrusion hole (10) provided in the lower portion of the crucible, so as to flow downward and form a series of separate drops (G) of melted metal alloy, said drops of melted metal alloy entering a cooling liquid (L) so as to solidify, thereby forming metallic-glass beads (B).
B22F 9/06 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide
B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensions; Appareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p.ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Doleans-Jordheim, Anne
Freney, Jean
Dumontet, Charles
Boumendjel, Ahcène
Veron, Jean-Baptiste
Wong, Yung-Sing
Abrégé
The present invention relates to compounds of formula (I), where R1 and R2, identical or different, are each independently a hydrogen atom or a non-substituted or substituted (C1-C12) alkyl group; R3 is a hydrogen atom or a non-substituted or substituted (C1-C6) alkyl group; R4 is a non-substituted or substituted (C1-C12) alkyl group or an aryl or heteroaryl group, said aryl and heteroaryl groups being non-substituted or substituted; and R5 is a non-substituted or substituted (C1-C12) alkyl group; or R4 and R5 are bonded to one another by a saturated hydrocarbon chain having 3 or 4 carbon atoms, optionally in hydrated form or in the form of a salt that is acceptable for being administered to animals or plants, for the use thereof as a potentiator of the effect of an antimicrobial agent or for the use thereof as an antimicrobial agent.
C07D 215/06 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle comportant uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés à l'atome d'azote du cycle
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Issartel, Jean-Paul
Berger, François
Lages, Elodie
Guttin, Audrey
El Atifi-Borel, Michèle
Ipas, Hélène
Abrégé
The invention relates to a method for the in vitro diagnosis of a brain tumour belonging to the group consisting of two types of tumours - ODG and GBM - and the identification of the type of tumour, comprising the measurement of the expression levels of at least one first and one second miRNA respectively belonging to two different miRNA groups, in a sample from a patient suspected of having one of said brain tumours.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
48.
INTRA-TISSUE IN VITRO DIAGNOSIS METHOD FOR DIAGNOSING BRAIN TUMOURS
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Issartel, Jean-Paul
Berger, François
Lages, Elodie
Guttin, Audrey
El Atifi-Borel, Michèle
Ipas, Hélène
Abrégé
The invention relates to a method for the in vitro diagnosis of a brain tumour belonging to the group consisting of two types of tumours - ODG and GBM - and the identification of the type of tumour, comprising the measurement of at least two ratios of the expression levels of miRNA pairs extracted from a biological sample from a patient suspected of having one of said brain tumours.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT POLYTECHNIQUE DE GRENOBLE (France)
Inventeur(s)
Deronzier, Alain
Godet-Bar, Thibault
Lepretre, Jean-Claude
Sanchez, Jean-Yves
Abrégé
The invention pertains to rechargeable metal ion cell comprising: - an anode comprising at least one metal; - a charge-carrying electrolyte comprising a charge carrying medium and at least one metal salt; - an organic polymer cathode, wherein said cathode comprises at least one N- substituted polyphenothiazine polymer [polymer (P)], said polymer comprising at least one N-substituted phenothiazine recurring unit of formula: wherein R' is an electron-withdrawing group comprising at least one heteroatom selected from O, S, P and N.
H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif
H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques
H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
H01M 4/137 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif Électrodes pour accumulateurs à électrolyte non aqueux, p.ex. pour accumulateurs au lithium; Leurs procédés de fabrication Électrodes à base de polymères électro-actifs
C07D 279/18 - Thiazines-1, 4; Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons
C07D 279/22 - Thiazines-1, 4; Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons avec des atomes de carbone liés directement à l'atome d'azote du cycle
C07D 279/30 - Thiazines-1, 4; Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques condensés en [b, e] avec deux cycles à six chaînons avec des atomes de carbone liés directement à l'atome d'azote du cycle avec des radicaux acyle liés à l'atome d'azote du cycle
50.
DERIVATIVES OF 6-AMINO-6-DEOXYGLUCOSAMINE AND USE OF SAME AS ANTIBACTERIAL AGENTS
The invention relates to compounds of formula (I) where: R1 ≠ 2-deoxystreptamine and the derivatives thereof substituted in positions 5 and/or 6; R2 and R6 are the same or different and represent a primary, secondary or tertiary amine function: NH2, NHR, NRR' where R and R' = alkyl, aryl, cyclic or otherwise, substituted or otherwise; OR3 and OR4 form alcohol, ether, ester, carbonate, carbamate, sulfonate or sulfamate functions; and if R3 = R4, then R3 and R4 ≠ H; if R3 = H, then R4 ≠ H and R1 ≠ OH; and if R4 = H, then R3 ≠ H and R1 ≠ OH; if R1 = OH, then R3 and R4 ≠ H, and if R1 = OR5, then R3 and/or R4 and/or R5 are not a sugar or a polysaccharide. The invention further relates to the use of said compounds as drugs and, specifically, as antibiotics.
A61K 31/7008 - Composés ayant un groupe amino lié directement à un atome de carbone du radical saccharide, p.ex. D-galactosamine, ranimustine
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p.ex. phloridzine liés à un système carbocyclique condensé, p.ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
INSTITUT CATALÀ DE NANOTECNOLOGIA (ICN) (Espagne)
INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles Louis
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writable magnetic element comprising a film multilayer containing a write magnetic film, characterized in that the multilayer comprises a central film (13, 53, 100) made of at least one magnetic material having a magnetization with a magnetization direction parallel to the plane of the central film (13, 53, 100), the latter being sandwiched between a first external film (12, 52, 101) and a second external film (14, 54, 102) both made of non-magnetic materials, the first external film (12, 52, 101) comprising a first non-magnetic material and the second external film (14, 54, 102) comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and in that the element comprises a device for making a write current flow through the second external film (14, 54, 102) and the central film (13, 53, 100) in a flow direction parallel to the plane of the central film (13, 53, 100) and at an angle α of 90o ± 60o, especially of 90o ± 30o and more particularly 90o ± 15o to said magnetization direction, so as to generate a useful magnetic field in the central film (13, 53, 100), this current being made to flow either in a first direction, or in a second direction opposite to the first direction, so as to orient the magnetization direction in a first magnetization direction or in a second magnetization direction opposite to the first magnetization direction.
G11C 11/14 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments à pellicules minces
G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
H01L 27/22 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun utilisant des effets de champ magnétique analogues
52.
USE OF SPECIFIC GENES OR THEIR ENCODED PROTEINS FOR A PROGNOSIS METHOD OF CLASSIFIED LUNG CANCER
The present invention relates to the use of at least one element for the implementation of a prognosis method, preferably in vitro, of the survival rate of a patient afflicted by a lung cancer, said lung cancer being previously classified as a lung tumour belonging from the group consisting of squamous cell carcinoma (SQC), adenocarcinoma (ADK), large cell neuro-endocrine tumours (LCNE) and basaloid tumours (BAS).
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
Centre National de la Recherche Scientifique (France)
Commissariat a l'Energie Atomique Et Aux Energies Alternatives (France)
Universite Joseph Fourier (France)
Institut Catala de Nanotechnologia (ICN) (Espagne)
Institucio Catalana de Recerca I Estudis Avancats (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting magnetization having a magnetization direction that is parallel to the plane of the central layer, which layer is sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and wherein it includes a device to cause a write current to pass through the second outer layer and the central layer in a current flow direction parallel to the plane of the central layer at an angle α lying in the range 90°±60°, in particular 90°±30°, and more particularly 90°±15° relative to said magnetization direction in order to generate an effective magnetic field in the central layer, the current being applied either in a first direction or in a second direction opposite to the first, in order to orient the magnetization direction in a first magnetization direction or in a second magnetization direction opposite to the first.
H01L 21/00 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de dispositifs à semi-conducteurs ou de dispositifs à l'état solide, ou bien de leurs parties constitutives
54.
USE OF SPECIFIC GENES FOR THE PROGNOSIS OF LUNG CANCER AND THE CORRESPONDING PROGNOSIS METHOD
The invention relates to the use of at least 13 genes chosen among a set of 28 genes for carrying out a method for identifying at least 66% of patients of those having a survival rate of at most about 20% at 30 months, among a population of patients afflicted by lung cancer having an estimated survival rate of at least 30% at 30 months based on the diagnosis of said lung cancer according to histopathological criteria.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
55.
PRODUCTION OF POLYCRYSTALLINE SILICON BY NATURAL SINTERING FOR PHOTOVOLTAIC APPLICATIONS
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Lebrun, Jean-Marie
Missien, Jean-Michel
Pascal, Céline
Garandet, Jean-Paul
Servant, Florence
Abrégé
The invention relates to a silicon sintering process, with no external force added, which comprises positioning a silicon sample in a furnace and then heat-treating this sample at least at a certain temperature and with at least a partial pressure of oxidizing species in order to control the thickness of a silicon oxide layer on the surface thereof.
H01L 31/0368 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur structure cristalline ou par l'orientation particulière des plans cristallins comprenant des semi-conducteurs polycristallins
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
56.
ELECTROCHEMICAL GENERATOR AND METHOD OF PRODUCING SUCH A GENERATOR
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Crepel, Lauréline
Alloin, Fannie
Lepretre, Jean-Claude
Martinet, Sébastien
Abrégé
The invention relates to an electrochemical generator comprising a first electrode covered by a passivation layer having a compound formed by the repetition of a unit of formula (7) in which n is an integer between 1 and 10, preferably between 1 and 4; R1 and R2 are identical or different and chosen independently from the group formed by -CH2- and a cyclic or acyclic, linear or branched alkyl chain; R3 is chosen from the group formed by -CH3, a cyclic or acyclic, linear or branched alkyl chain and a group of formula (8) in which: A' is a monocyclic or polycyclic, aromatic hydrocarbon group, chosen from the group formed by phenyl, aryl groups and condensed, polyaromatic groups, these being optionally substituted; R4 is chosen from the group formed by -CH2- and a cyclic or acyclic, linear or branched alkyl chain; and A is identical to or different from A'. The unit has no hydroxyl functions and is grafted onto the first electrode via group A, and when R3 is a group of formula (8), via groups A and A'.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
H01M 10/0567 - Matériaux liquides caracterisés par les additifs
H01M 10/0563 - Matériaux liquides, p.ex. pour éléments au Li-SOCl2
57.
ARYL DIAZONIUM SALT AND USE IN AN ELECTROLYTIC SOLUTION OF AN ELECTROCHEMICAL GENERATOR
COMMISSARIAT À L' ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Crepel, Lauréline
Alloin, Fannie
Lepretre, Jean-Claude
Martinet, Sébastien
Abrégé
The invention relates to an aryl diazonium salt free of hydroxyl functions of general formula (1) in which n is an integer between 1 and 10, preferably between 1 and 4, X" represents a counterion of the diazonium cation chosen from halides, BF4-, NO3-, HSO4-, PF6-, CH3COO-, N(SO2CF3)2-, CF3SO3-, CH3SO3-, CF3COO-, (CH3O)(H)PO2-, N(CN)2-, R1, R2 and R4 are identical or different and are chosen independently from the group constituted by -CH2-, a cyclic or acyclic, linear or branched alkyl chain and A and A' are identical or different and independently represent a monocyclic or polycyclic aromatic hydrocarbon-based group chosen from the group constituted by phenyl, aryl groups, and condensed polyaromatic groups, which are optionally substituted.
H01M 4/02 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif
H01M 10/36 - Accumulateurs non prévus dans les groupes
H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
H01M 4/13 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Électrodes Électrodes composées d'un ou comprenant un matériau actif Électrodes pour accumulateurs à électrolyte non aqueux, p.ex. pour accumulateurs au lithium; Leurs procédés de fabrication
The invention relates to a high-frequency transmission line comprising a central conductor strip (6) associated with at least one conductor shielding plane (4). In said transmission line, at least some of the space between the conductor plane and the conductor strip comprises a ferroelectric material (10).
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Cosnier, Serge
Holzinger, Michael
Le Goff, Alan
Zebda, Abdelkader
Abrégé
The invention relates to a biopile electrode or biosensor electrode intended to be immersed in a liquid medium containing a target and an oxidizer, respectively a reducer, in which the anode comprises an enzyme able to catalyse the oxidation of a target, and the cathode comprises an enzyme able to catalyse the reduction of the oxidizer, and in which each of the anode electrode and cathode electrode consists of a solid agglomeration of carbon nanotubes mixed with the enzyme, and is secured to an electrode wire.
H01M 4/90 - Emploi de matériau catalytique spécifié
H01M 8/16 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible biochimique, c. à d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
INSTITUT CATALÀ DE NANOTECNOLOGIA (ICN) (Espagne)
INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles Louis
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writeable magnetic element, comprising a stack of layers having a magnetic writing layer, characterised in that the stack comprises a central layer (13, 53, 90) made of at least one magnetic material having a direction of magnetisation that is parallel or perpendicular to the plane of the central layer, wherein said central layer, which forms such a magnetic writing layer, is sandwiched between a first (12, 52, 91) and second (14, 54, 92) outer layer made of non-magnetic materials, the first outer layer (12, 52, 91) comprising a first non-magnetic material and the second outer layer (14, 54, 92) comprising a second non-magnetic material other than the first non-magnetic material, wherein at least the second non-magnetic material is electrically conductive, and characterised in that said element comprises a device for passing a writing current only through the second outer layer and the central layer, and optionally through the first outer layer only in the event the latter is conductive, said writing current circulating in a current direction that is parallel to the plane of the central layer, as well as a device for applying, in the presence of said writing current, a writing magnetic field in a magnetic-field direction that is perpendicular to the plane of the central layer (13, 53, 90), the memory being written to in one of the directions of magnetisation by controlling the direction of the applied writing magnetic field.
H01L 43/08 - Résistances commandées par un champ magnétique
G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
H01F 10/32 - Multicouches couplées par échange de spin, p.ex. superréseaux à structure nanométrique
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
INSTITUT CATALÀ DE NANOTECNOLOGIA (ICN) (Espagne)
INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles, Louis
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writeable magnetic element, comprising a stack of layers having a magnetic writing layer, characterised in that the stack comprises a such a magnetic writing layer, namely a central layer (13, 53, 70, 23, 63, 80) made of at least one magnetic material having a direction of magnetisation that is parallel or perpendicular to the plane of the central layer, which is sandwiched between a first (12, 52, 71, 22, 62) and second (14, 54, 72, 24, 64, 82) outer layer made of non-magnetic materials, the first outer layer (12, 52, 71, 22, 62) comprising a first non-magnetic material and the second outer layer (14, 54, 72, 24, 64, 82) comprising a second non-magnetic material other than the first non-magnetic material, wherein at least the second non-magnetic material is electrically conductive, and characterised in that said element comprises a device for passing a writing current only through the second outer layer and the central layer, and optionally through the first outer layer only in the event the latter is conductive, said writing current circulating in a current direction that is parallel to the plane of the central layer, as well as a device for applying a magnetic field having a component in one magnetic-field direction that is either parallel or perpendicular to the plane of the central layer (13, 53, 70, 23, 63, 80) and to the current direction, and in that the direction of magnetisation and the magnetic-field direction are mutually perpendicular.
G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliers; Eléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
Centre National de la Recherche Scientifique (France)
Commissariat a l'Energie Atomique et aux Energies Alternatives (France)
Universite Joseph Fourier (France)
Institut Catala de Nanotechnologia (Espagne)
Institucio Catalana de Recerca I Estudis Avancats (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting a direction of magnetization that is perpendicular to the plane of the central layer, said central layer being sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, and wherein it includes a device for causing current to flow through the second outer layer in a current flow direction parallel to the plane of the central layer, and a device for applying a magnetic field along a magnetic field direction that is perpendicular to the plane of the central layer.
Centre National de la Recherche Scientifique (France)
Commissariat a l'Energie Atomique et aux Energies Alternatives (France)
Universite Joseph Fourier (France)
Institut Catala de Nanotechnologia (ICN) (Espagne)
Institucio Catalana de Recerca I Estudis Avancats (ICREA) (Espagne)
Inventeur(s)
Gaudin, Gilles
Miron, Ioan Mihai
Gambardella, Pietro
Schuhl, Alain
Abrégé
The invention relates to a writable magnetic element comprising a stack of layers presenting a write magnetic layer, wherein the stack has a central layer of at least one magnetic material presenting a direction of magnetization that is parallel or perpendicular to the plane of the central layer, said central layer being sandwiched between first and second outer layers of non-magnetic materials, the first outer layer comprising a first non-magnetic material and the second outer layer comprising a second non-magnetic material that is different from the first non-magnetic material, at least the second non-magnetic material being electrically conductive, wherein it includes a device for causing current to flow through the second outer layer and the central layer in a current flow direction parallel to the plane of the central layer, and a device for applying a magnetic field having a component along a magnetic field direction that is either parallel or perpendicular to the plane of the central layer and the current flow direction, and wherein the magnetization direction and the magnetic field direction are mutually perpendicular.
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Blin, Dominique
Abrégé
The present invention relates to a device for controlling a blood flow produced in a hemorrhagic area (4) of biological tissue (8), including a flexible plate (2) that is arranged so as to be placed opposite said area (4) and includes: a substantially sealed peripheral bearing means (3) capable of being applied onto the biological tissue (8) while surrounding the hemorrhagic area; a bottom wall (5) that defines, together with the bearing means (3), a hollow space (6) opposite the area (4); a connection means (14, 15) arranged so as to connect the hollow space (6), outside the flexible plate (2), to an outer suction source so as to create, within the hollow space (6), a vacuum for suctioning and tightly applying the surface (7) of the tissue (8) against the peripheral bearing means (3); and a hollow contact pad (11) which is placed between the area (4) and the bottom wall (5), which has a recess in the center thereof on the area (4) side and along an axis (10) substantially perpendicular to the bottom wall, and which is arranged so as to be in contact with the area (4) when the vacuum is created in the space (6).
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
A61M 27/00 - Appareillage pour drainage des blessures
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Blin, Dominique
Abrégé
The present invention relates to a hemostatic device (23) for controlling a blood flow occurring in a hemorrhagic zone (4) located in a hollow component, comprising: - a flexible plate (26) equipped with two opposing faces (27, 28), substantially parallel, said plate comprising an empty internal volume (29) between its two faces, and - connection means (30) linked for connecting the internal volume (29) to suction means external to said device, so as to create a depression in this internal volume (29), said connection means typically comprising a connecting tube (31), each of the faces (27, 28) being equipped with holes (32) that communicate, via these faces (27, 28), the internal volume (29) and the exterior of the plate such that when said depression is created in the internal volume, the suction is applied simultaneously to two opposite walls of the hollow component so as to keep them close together.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
A61M 27/00 - Appareillage pour drainage des blessures
66.
DEVICE FOR CONTROLLING A BLOOD FLOW PRODUCED IN A HEMORRHAGIC AREA
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
Inventeur(s)
Blin, Dominique
Abrégé
The present invention relates to a device for controlling a blood flow produced in a hemorrhagic area (4) of biological tissue (8), including a flexible plate (2) that is arranged so as to be placed opposite said area (4) and includes: a substantially sealed peripheral bearing means (3) capable of being applied onto the biological tissue (8) while surrounding the hemorrhagic area; a bottom wall (5) that defines, together with the bearing means (3), a hollow space (6) opposite the area (4); a connection means (14, 15) arranged so as to connect the hollow space (6), outside the flexible plate (2), to an outer suction source so as to create, within the hollow space (6), a vacuum for suctioning and tightly applying the surface (7) of the tissue (8) against the peripheral bearing means (3); and a hollow contact pad (11) which is placed between the area (4) and the bottom wall (5), which has a recess in the center thereof on the area (4) side and along an axis (10) substantially perpendicular to the bottom wall, and which is arranged so as to be in contact with the area (4) when the vacuum is created in the space (6).
A61M 1/00 - Dispositifs de succion ou de pompage à usage médical; Dispositifs pour retirer, traiter ou transporter les liquides du corps; Systèmes de drainage
A61M 27/00 - Appareillage pour drainage des blessures
The invention relates to a triangular patch resonator with a triangle pattern (30), in which the two sides of the triangle that are symmetrical in relation to an axis are associated respectively with an input coupler and an output coupler, comprising slots in the form of three-arm stars, namely: a first slot (41) extending along the aforementioned axis on each side of the centre of the triangle and two other slots (42, 43) extending symmetrically from the base of the first slot, with none of said slots opening out to the exterior. In addition, an adjustable capacitor (51-53) is connected through each of the slots.
The invention relates to a device for processing a fluid, in particular sludge, including: an enclosure (E) delimiting a chamber (C) for the flow of the fluid, and including a longitudinal tubular wall (2) and end walls, at least one transmitting device including a bar (6) which is immersed and extends longitudinally into said chamber, and which is capable of radially generating an ultrasonic vibration, and an arrangement (12) placed in the space between the tubular wall (2) and the bar (6) of the transmitting device and including at least one obstacle (13) which deflects the flow of the fluid, and which has an inner edge located at a distance from the bar in such a manner as to leave at least one inner passage between said inner edge and the bar, said inner passage being placed in the area of a bulge of the radial ultrasonic vibration, in such a manner that the fluid can pass from one side of said obstacle to the other by flowing along the bar, and in correspondence with said bulge of the radial ultrasonic vibration.
The present invention relates to the use of a peptide comprising the amino acid sequence SEQ ID NO: 1, or of a peptide comprising an amino acid sequence having 93%, especially 95%, in particular 98% sequence identity homology with the sequence SEQ ID NO: 1, for obtaining a transporter intended for the internalization of a molecule of diagnostic or therapeutic interest into target cells.
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
A61K 47/42 - Protéines; Polypeptides; Leurs produits de dégradation; Leurs dérivés p.ex. albumine, gélatine ou zéine
The invention relates to a high-frequency transmission line including a conductive tape (6) associated with a shielding surface (4) that is placed under the line structure and is divided into parallel microstrips in a direction generally orthogonal to the direction of the line, said microstrips being movable relative to the conductive tape.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT CURIE (France)
Inventeur(s)
Popov, Andrei
Juhem, Aurélie
Florent, Jean-Claude
N'Guyen, Chi-Hung
Abrégé
The invention relates to the use of isoquinolones for preparing drugs, including novel isoquinolones. The invention also relates to said novel isoquinolones as well as to the method for synthesising same. In particular, the invention relates to isoquinolone derivatives used in the treatment of pathological angiogeneses, specifically cancer.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
C07D 217/22 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle contenant l'azote
G01N 33/573 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour enzymes ou isoenzymes
C07K 16/40 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre des enzymes
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
73.
DEVICE FOR TRANSIENTLY CONTACTING AT LEAST ONE UNIT FOR CAPTURING BIOLOGICAL TARGETS WITH A FLUID CONTAINING THEM, METHOD FOR RECOVERING THE CAPTURED TARGETS AND SYSTEM FOR CONTACTING AND RECOVERY
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Caillat, Patrice
Berger, François
Campagnolo, Raymond
Cosnier, Marie-Line
Zaccaria, Affif
Abrégé
The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device (1) according to the invention comprises: - a sampling tip (2) having a contacting end intended to be introduced into a medium containing said fluid, and - the or each capturing unit which is bound to said end and which comprises a capture substrate (3) defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer (4) designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
74.
PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gans, Pierre
Boisbouvier, Jérôme
Ayala, Isabel
Hamelin, Olivier
Abrégé
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
C07C 51/367 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par introduction de groupes fonctionnels contenant l'oxygène lié uniquement par une liaison simple
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gans, Pierre
Boisbouvier, Jerome
Ayala, Isabel
Hamelin, Olivier
Abrégé
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
C07C 51/367 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides par des réactions ne créant pas de groupes carboxyle par introduction de groupes fonctionnels contenant l'oxygène lié uniquement par une liaison simple
The present application relates to the use of miRNAs as biomarkers in glioma diagnosis. The application moreover relates to the use of miRNAs as biomarkers in glioblastoma and oligodendroglioma diagnosis.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
77.
Capacitive detector, method for manufacturing same, and device for measuring the integral
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G08B 21/00 - Alarmes réagissant à une seule condition particulière, indésirable ou anormale, et non prévues ailleurs
78.
CONTROL SYSTEM AND METHOD FOR PRECISELY GUIDING A PERCUTANEOUS NEEDLE TOWARD THE PROSTATE
The present invention relates to a needle holder device (40) for treating the prostate, involving a series of steps of inserting a needle into the prostate, comprising a rectal probe (2) for ultrasonic 3D imaging and a computer for processing the image acquired by said probe and for computing the position of the needle (3) relative to the prostate. The computer is controlled so as to periodically output information on the movement of the prostate after each of the insertion steps in order to validate the insertion parameters relative to a treatment schedule and, if need be, modifying the insertion parameters relative to said schedule in the event the movement is greater than a threshold value.
A61B 8/08 - Détection de mouvements ou de changements organiques, p.ex. tumeurs, kystes, gonflements
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux, p.ex. tourniquets
A61B 19/00 - Instruments, outillage ou accessoires pour la chirurgie ou le diagnostic non couverts par l'un des groupes A61B 1/00-A61B 18/00, p.ex. pour stéréotaxie, opération aseptique, traitement de la luxation, protecteurs des bords des blessures(masques de protection du visage A41D 13/11; blouses de chirurgien ou vêtements pour malades A41D 13/12; dispositifs pour retirer, traiter ou transporter les liquides du corps A61M 1/00)
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (Espagne)
UNIVERSITE' JOSEPH FOURIER (France)
Inventeur(s)
Bernardi, Anna
Sattin, Sara
Clerici, Mario, Salvatore
Berzi, Angela, Maria, Vittoria
Rojo, Francisco, Javier
Sanchez, Macarena
Reina, Jose, Juan
Fieschi, Franck
Abrégé
The present invention finds application in the field of medicine and, in particular, it relates to new compounds for the treatment and/or prevention of HIV; Ebola, Dengue, Hepatitis C, SARS or tuberculosis infections.
C07H 15/207 - Cycles cyclohexane non substitués par des atomes d'azote, p.ex. kasugamycines
A61K 31/7034 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p.ex. phloridzine
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Omnes, Franck Jacques
Agnes, Charles
Ruffinatto, Sébastien
Mailley, Pascal
Abrégé
The invention relates to a method for grafting compounds onto a material including, on the surface thereof, an element selected from among carbon, silicon, and germanium, said method including the following steps: a) providing a material including, on the surface thereof, sp3 hybridized carbon, silicon, and/or germanium atoms having at least one hydrogen atom, and b) placing the material as provided in step a) in contact, in a solvent, with a compound (C) containing at least one unprotonated amino function, whereby said compound (C) is grafted onto said material.
B05D 5/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/53 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet
G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
Centre National de la Recherche Scientifique (C.N.R.S.) (France)
Universite Joseph Fourier (France)
Inventeur(s)
De Rango, Patricia
Chaise, Albin
Fruchart, Daniel
Marty, Philippe
Miraglia, Salvatore
Abrégé
The tank is of the type including a container (4) for housing hydrogen, and metallic hydride placed inside the container. According to one aspect of the invention, it includes at least one solid body (6) formed of a compacted material including metallic hydride and a matrix. Application in particular for tanks for internal combustion engines or for fuel cells, in particular for motor vehicles, as well as for any stationary or mobile application using hydrogen.
B01D 53/04 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse avec adsorbants fixes
F17C 11/00 - Utilisation de solvants ou d'absorbants des gaz dans les récipients
F17C 1/00 - Récipients sous pression, p.ex. bouteilles de gaz, réservoirs de gaz, cartouches échangeables
C01B 3/00 - Hydrogène; Mélanges gazeux contenant de l'hydrogène; Séparation de l'hydrogène à partir de mélanges en contenant; Purification de l'hydrogène
82.
METHOD FOR ETCHING A MATERIAL IN THE PRESENCE OF A GAS
The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing said compound; placing the structure (1) in a position such that the surface of the material to be etched is in the presence of the solution and additional bubbles of a gas; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating reactive cavitation bubbles such that the chemical species is generated in the presence of these additional bubbles and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.
The invention relates to a method for assaying the circulating extracellular portion of the IRAP ("insulin-responsive aminopeptidase") protein, including at least one step of quantitatively assaying the released and purified extracellular portion of the IRAP using at least one marked peptide, said marked peptide specifically interacting with said extracellular portion of the IRAP.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
G01N 33/68 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des protéines, peptides ou amino-acides
84.
METHOD FOR ETCHING A MATERIAL IN THE PRESENCE OF SOLID PARTICLES
The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing the compound and a powder of particles or solid grains (13) in suspension; placing the material to be etched in the presence of the solution; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating active cavitation bubbles such that the chemical species is generated and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.
The present invention relates to a polypeptide comprising or constituted of the sequence RILAR (SEQ ID NO: 3), the use thereof in imaging methods, in diagnostic or prognostic methods and for use as a medicament.
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p.ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénal
87.
OPTICAL FIBRE DEVICE FOR INTERFEROMETRIC ANALYSIS OF THE SURFACE CONDITION OF AN OBJECT
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
Inventeur(s)
Chevrier, Joël
Huant, Serge
Schwartz, Wilfrid
Siria, Alessandro
Abrégé
The invention relates to an optical device for the interferometric analysis of the surface condition of an object (2), including: a light source (1); an optical fibre (42) capable of receiving the incident light wave and transmitting said wave to the object (2); a detector (9) capable of detecting a combination between a light wave (45) reflected by the optical fibre and a light wave (46) returned by the object; and in which the optical fibre (42) has a free end in the shape of a cone, with a vertex angle of between 15 and 25 degrees, the tip of the cone having dimensions of less than 50 x 50 nm, and the tip of the cone being placed, while in use, at a distance of between 5 and 50 μm from the surface of the object.
G01B 11/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer des contours ou des courbes
G01B 21/00 - Dispositions pour la mesure ou leurs détails, où la technique de mesure n'est pas couverte par les autres groupes de la présente sous-classe, est non spécifiée ou est non significative
G01B 7/34 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer la rugosité ou l'irrégularité des surfaces
The present invention relates to a method and device for controlling a crystallisation using a steam source (10) in an isothermal system (8) to monitor the crystallization or recrystallization of a solid matter sample (9) that is initially at least partially amorphous and/or at least partially crystalline and contained within the system (8), said steam source (10) including at least one solvent for crystallizing said solid matter, the steam diffusion (14) of which causes the crystallization or recrystallization of the sample (9), said steam source (10) being such that the heat exchange amounts within the system during the crystallization or recrystallization of the sample (9) other than the crystallization or recrystallization heat of the sample are less than about 10%, particularly 5%, and advantageously 1% of the crystallization or recrystallization heat of the sample. The steam source (10) is preferably a pure solvent or a solvent mixture in which no solute is dissolved.
G01N 25/14 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en utilisant la distillation, l'extraction, la sublimation, la condensation, la congélation ou la cristallisation
A method for processing cardiac signals includes accepting, from a sensor system, a set of one or more signals, the signals including components of a desired cardiac signal and components of a substantially periodic interfering signal. The method is applicable for extraction of desired fetal cardiac signals from signals with interference from the maternal cardiac signal. A periodicity of the interfering signal is determined, and one or more iterations of mitigating an effect of a component of the signals that exhibit periodicity at the determined periodicity of the interfering signal are performed. In some examples, the method further includes determining a periodicity of the desired cardiac signal, and performing one or more iterations of enhancing an effect of a component of the signals that exhibit periodicity at the determined periodicity of the desired cardiac signal.
The device is characterized in that it comprises, in combination, a horizontal circular support plate (1) for animals (2), rotated about a vertical axis (3), a cylindrical wall (4) the outside diameter of which is approximately the same as that of the rotating plate (1), this wall delimiting an internal confining space (7) forming a cage for housing the animals moving freely on the plate, a fixed intermediate partition (12) extending inside the cylindrical wall (4) and dividing the internal confining space into two opposed compartments (13, 14), an upper closing lid (15), which is preferably removable, secured to the intermediate partition (12) and extending parallel to the plate (1), and a system (36) for supplying breathing gas through the closing lid (15) for the animals (2) present in the two opposed compartments (13, 14) of the confining space (7).
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
UNIVERSITE JOSEPH FOURIER (France)
Inventeur(s)
Gavillet, Jérôme
Caney, Nadia
Colasson, Stéphane
Marty, Philippe
Phan, Hai Trieu
Abrégé
The invention relates to a heat exchange structure that comprises a main surface (6) provided with blind holes (8) formed in said surface (6), the inner surface of the holes (8) and the surface (10) of said main surface outside the holes being covered with nanoparticles (12), the inside of the holes (8) having a non-wettability property relative to a given liquid, and the surface (10) of the surface between the holes (8) having a wettability property relative to said liquid.
H01L 23/373 - Refroidissement facilité par l'emploi de matériaux particuliers pour le dispositif
H01L 23/427 - Refroidissement par changement d'état, p.ex. caloducs
H01L 23/473 - Dispositions pour le refroidissement, le chauffage, la ventilation ou la compensation de la température impliquant le transfert de chaleur par des fluides en circulation par une circulation de liquides
F28D 15/04 - Appareils échangeurs de chaleur dans lesquels l'agent intermédiaire de transfert de chaleur en tubes fermés passe dans ou à travers les parois des canalisations dans lesquels l'agent se condense et s'évapore, p.ex. tubes caloporteurs avec des tubes ayant une structure capillaire
F28F 13/18 - Dispositions pour modifier le transfert de chaleur, p.ex. accroissement, diminution par application d'un traitement de surface, p.ex. un polissage
I.N.S.E.R.M. (Institut National de la Santé et de la Recherche Médicale) (France)
Inventeur(s)
Ghezzi, Catherine
Fagret, Daniel
Demongeot, Jacques
Perret, Pascale, Marie-Pierre
Abrégé
The present invention relates to the use of at least one glucose derivative, halogenated in the 6-position, for implementing a method for determining the insulin resistance in a mammal, in particular a human, by measuring - the variation in the amount (as a function of time) of the abovementioned derivative, in muscle cells, for a given period Δt, after administration of the abovementioned derivative, and - the variation in the amount (as a function of time) of the abovementioned derivative, in the abovementioned muscle cells, for a period substantially equal to the abovementioned period Δt, after administration of the abovementioned derivative, preceded by an administration of insulin.
G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
The present invention relates to an NS5B protein of the hepatitis C virus (HCV), efficient for replication, which carries a point mutation in at least one of the following positions: - at the position corresponding to residue 262 of SEQ ID NO: 1; and/or - at the position corresponding to residue 265 of SEQ ID NO: 1; and/or - at the position corresponding to residue 316 of SEQ ID NO: 1.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
95.
HYBRID PROTEINS COMPRISING MEMBRANE RECEPTOR AND ION CHANNEL, AND THEIR USE AS BIOSENSORS
The present invention relates to the use of a hybrid protein comprising the sequence of a first membrane receptor fused at its C-terminus to the N-terminus of an ion channel, and possibly containing a linker between the C-terminus of said first membrane receptor and the N-terminus part of said ion channel, said linker being absent in the natural configuration of said first membrane receptor and said ion channel, as a biosensor for: the screening of drugs modulating the activity of said first membrane receptor in its natural configuration, and/or for the in vitro diagnosis of pathologies associated with the presence or the variation of amount of a molecule modifying the activity of said first membrane receptor in its natural configuration.
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p.ex. acides nucléiques
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE (France)
Inventeur(s)
Pellissier, Aymeric
Gondran, Chantal
Lenouvel, François
Cinquin, Philippe
Cosnier, Serge
Mathe, Stéphane
Abrégé
The invention relates to a battery (10) that includes first and second chambers (14A, 14B) containing a solvent and separated by a wall (16) permeable to said solvent and impermeable to hydroxyl and/or hydronium ions, a first electrode (18A) provided in the first chamber, a second electrode (18B) provided in the second chamber. A first redox pair includes a first oxidiser and a first reducer involved in first oxidation-reduction reactions leading to an electron exchange with the first electrode. A second redox pair includes a second oxidiser and a second reducer involved in second oxidation-reduction reactions leading to an electron exchange with the second electrode. The wall is impervious to the first and second redox pairs. First enzymes or first micro-organisms are provided in the first or second chamber, and promote third oxidation-reduction reactions leading to the conversion of a first substance in order to produce a second substance containing basic or acidic species in the solvent of the first and/or second chamber.
H01M 8/16 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible biochimique, c. à d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
H01M 8/20 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication Éléments à combustible indirects, p.ex. éléments à combustible avec un couple REDOX irréversible
98.
DEVICE FOR POSITIONING A MOVEABLE OBJECT OF SUBMICRON SCALE
The invention relates to a device for positioning a moveable object (1) which can be moved over a distance of the order of 1 nanometre in a time of 1 microsecond or less, comprising: a microtip (6); first piezoelectric positioning, polarization, detection and control means (8, 10) for moving the microtip relative to the object and bringing it to a distance of the order of 1 nanometre from the object, in order to make a tunnel current flow between the microtip and the object, for measuring the tunnel current and for slaving, depending on the measured tunnel current, the distance between the microtip and the object to a constant value (dref); and second positioning and control means (4, 10) which are capacitively coupled to the object so as to oppose an attractive force between the object and the microtip depending on the measured tunnel current, the second means being tied to a reference plane (3).
G01P 15/08 - Mesure de l'accélération; Mesure de la décélération; Mesure des chocs, c. à d. d'une variation brusque de l'accélération en ayant recours aux forces d'inertie avec conversion en valeurs électriques ou magnétiques
G01P 15/13 - Mesure de l'accélération; Mesure de la décélération; Mesure des chocs, c. à d. d'une variation brusque de l'accélération en ayant recours aux forces d'inertie avec conversion en valeurs électriques ou magnétiques en mesurant la force nécessaire pour remettre à sa position de repos une masse d'épreuve soumise aux forces d'inertie
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (France)
Inventeur(s)
Pison-Rousseaux, Sophie
Khochbin, Saadi
Abrégé
The invention relates to the use of one element chosen among a nucleic acid molecule, a fragment of said nucleic acid molecule and a variant of the said nucleic acid molecule for the in vitro or ex vivo diagnosis of any type of somatic or ovarian cancers, wherein at least one of any of the above described elements is abnormally expressed in cancer cells of at least one type of the somatic or ovarian cancers, and wherein each type of somatic or ovarian cancer cells abnormally expresses at least one of the above described elements.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
100.
CAPACITIVE DETECTOR, METHOD FOR MANUFACTURING SAME, AND DEVICE FOR MEASURING THE INTEGRAL
The invention relates to a capacitive detector and device for measuring the detector integral, including: a ribbon in a dielectric material (2), first and second electrodes (4, 5) shaped like combs and formed on a first surface of said ribbon, and a third electrode formed on the other surface of said ribbon and facing said first and second electrodes; the thickness (e) of the dielectric ribbon (2) is less than or equal to said predetermined period (λ) divided by four times pi, or λ/4π≥e; and the relationship resulting from division, in the numerator, of the capacity (C) between two adjacent branches (9, 11) of said first and second electrodes in the presence of at least one fluid having dielectric permittivity (εf) and, in the denominator, by the dielectric permittivity (εf) of the fluid multiplied by the capacity (Co) between the two adjacent branches of the first and second electrodes in the presence of the void is greater than or equal to one, or C/εf.Co≥ l. The invention further relates to a method for manufacturing a detector respecting the above conditions.
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p.ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p.ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques