Orthosis device (1), comprising a belt (2), comprising a compression layer (4) comprising opposite ends (5) that are moveable towards and away from each other to tighten and untighten the belt; and an actuator (6) comprising a drive (14), wherein the orthosis device is configured to provide temporary support to a lumbar region of a user during a load transfer activity by the user, the belt further comprising a base layer (3); the compression layer being slidably arranged against at least a part of said base layer during tightening and untightening of the belt; and said actuator being configured to selectively switch the orthosis device between an active state and an idle state, wherein, in order to bring the orthosis device into the active state, the actuator is configured to tighten the belt to provide an increased level of support during the load transfer activity; and in order to bring the orthosis device into the idle state, the actuator is configured to untighten the belt to provide an increased level of wearing comfort.
KETEK GmbH Halbleiter- und Reinraumtechnik (Germany)
Universiteit Twente (Netherlands)
Inventor
Bachmann, Michael
Edler, Simon
Jonker, Dirk
Gardeniers, J.G.E.
Abstract
In an embodiment a reactor includes an electron source having a first gate-insulator-substrate electron-emission structure (GIS-EE) and configured to inject electrons into a fluid and a transportation system for the fluid configured to adjust a velocity of the fluid when passing the electron source, wherein the electron source is configured to provide the electrons to be injected into the fluid in an interior of the electron source and distant from the fluid, wherein the injected electrons are to initiate at least one chemical reaction in the fluid, wherein, when reaching the fluid, at least part of the injected electrons has a kinetic energy of at most 50 eV, wherein the electrons are propagatable only in solid matter from the interior until emission into the fluid, and wherein the GIS-EE includes an electrically conductive substrate, a transfer layer of a material with a band gap of at least 4 eV on the substrate, a gate electrode of a further electrically conductive material directly on the transfer layer, a first electrical connection structure on the substrate, and a second electrical connection structure on the gate electrode.
A method is provided for the analysis of DLA products incorporating aliquots of leukocytes for processing using CellSearch (DLA-CS). The Reduced Enrichment Reagent protocol (RER) is used to process 0.2x109leukocyte aliquots with 10-fold less enrichment reagents than DLA-CS. Using 1.0x109 leukocyte aliquots a 4-fold increase in tumor cells compared to DLA-CS and a 24-fold increase compared to PB-CS was obtained. Using 10-fold less CellSearch capture reagent, we processed standard leukapheresis aliquots with no loss in tumor cell recovery, while attaining a higher purity. The method allows for 26% of the total leukapheresis sample to be processed using CellSearch reagents, enabling a sufficient number of CTC for tumor cell characterization in most metastatic prostate cancer patients. By the use of DNase the normally seen clumping of cells during the magnetic enrichment procedure is prevented, allowing better identification and further processing of the enriched CTC.
The invention relates to a method for controlling an angular orientation of a spinning body with respect to an axis of rotation of the spinning body, comprising the steps of: a) providing the spinning body at a first stable angular orientation with respect to its axis of rotation, the spinning body having three principal moments of inertia about three orthogonal principal axes, the three principal moments of inertia defining a tensor of inertia, wherein the three principal moments of inertia each have a first value and wherein the first values of the three principal moments of inertia are identical so that the tensor of inertia is spherical; b) selecting a second angular orientation of the spinning body with respect to its axis of rotation, the second angular orientation being any angular orientation of the spinning body; and c) varying a value of at least one of the principal moments of inertia in accordance with a predetermined schedule, such that: c1. initially the three principal moments of inertia no longer have identical values and the tensor of inertia is non-spherical, thus causing the angular orientation of the spinning body to gradually change from the first angular orientation to the second angular orientation; and c2. eventually the three principal moments of inertia have identical values again and the tensor of inertia is spherical again to stabilize the spinning body in its second angular orientation. The invention further relates to a system for performing this method, and to a spinning body which comprises such a system.
The invention provides a parallel manipulator element (1000), the parallel manipulator element (1000) comprising a joint element (300), a strut (200) and a flexure element (100), wherein: (I) the flexure element (100) comprises (i) a first element end (110) and a second element end (120), (ii) an element length (LFE), (iii) an element width (WFE), (iii) an element thickness (TFE), wherein the element length (LFE) and the element width (WFE) define an element plane (PE), and (iv) a longitudinal element axis (Al), and a width axis (A4); (II) the strut (200) comprises a first strut end (210), a second strut end (220), and a longitudinal strut axis (A3); wherein: (a) the longitudinal element axis (Al) and the strut axis (A3) define a translation plane (PT), and (b) the width axis (A4) is perpendicular to the longitudinal axis (Al) and parallel to the element plane (PE); (c) the joint element (300) is connected to the second strut end (220), wherein the joint element (300) is configured for connecting the strut (200) to a dynamic movable object (2500); (d) the second element end (120) is connected to the first strut end (210), wherein the strut axis (A3) and the element axis (Al) define an angle (a); (e) the first element end (110) is configured for connecting the flexure element (100) to a static object (2010); (f) the flexure element (100) is configured for (i) twisting around the longitudinal element axis (Al), (ii) rotating (bending) around the width axis (A4), and (iii) translating the second element end (120) in a direction parallel to the translation plane (PT), when being connected to the static object (2010) at the first element end (110) and to the dynamic movable object (2500) with the joint element (300) via the second element end (120).
The present application concerns a method for manufacturing an aluminium oxide optical waveguide doped with rare earth ions. The present application further concerns an aluminium oxide optical waveguide doped with rare earth ions that are preferably manufactured by said method. According to the present invention, the method comprises providing a substrate, depositing an aluminium oxide waveguide core layer doped with ions of a rare earth metal onto the substrate, and arranging a cladding layer on the deposited waveguide core, said arranging comprising at least one processing step during which the deposited waveguide core is subjected to a given maximum temperature. The method is characterized in that depositing the waveguide core comprises forming nano-crystallites in the waveguide core. A lowest temperature at which a quenching percentage of the deposited waveguide core significantly increases, exceeds the given maximum temperature, wherein the given maximum temperature is about 400 degrees Celsius or higher.
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM (Netherlands)
UNIVERSITEIT TWENTE (Netherlands)
Inventor
Van Bochove, Jan Bastiaan
Grijpma, Dirk Wybe
Poot, Andreas Anthonius
Van Dommelen, Lieke Henrica Anna
Van Kuppevelt, Antonius Henricus Minardus Severus Marie
Daamen, Wilhelmina Francisca
Abstract
Disclosed is a functionalized collagen material comprising insoluble collagen fibrils having attached acrylic side groups, preferably methacrylate groups, and a crosslinked network of said functionalized collagen. Also disclosed is a hybrid polymer co-network made of acryl-functionalized collagen, particularly insoluble collagen fibrils, and an acryl-functionalized hydrophobic biodegradable polymer, preferably poly(trimethylene carbonate). The polymers are dissolved or dispersed in a common solvent, and subjected to reaction so as to enable the acryl groups to form crosslinks within either polymer, and between both of the polymers.
The present application concerns a switchable optical light source comprising a coherent light source and a light switching unit, configured to receive coherent light from the coherent light source. The light switching unit comprises a first optical resonator into which the coherent light is optically coupled, and a second optical resonator optically coupled to the first optical resonator. The first and second optical resonators are both Kerr active and Brillouin active. By changing the coupling factor corresponding to the optical coupling between the first and second optical resonators, and at least one of (A) an optical path length of at least one of the first and second optical resonators and (B) a frequency of the coherent light, the switchable optical light source can be switched between operating in a first operational state, in which the switchable optical light source functions as a Kerr frequency comb generator and a second operational state, in which the switchable optical light source functions as a Brillouin laser.
G02F 1/225 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference in an optical waveguide structure
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
10.
METHOD FOR DETECTING FLUID PARAMETERS USING A FLOW SENSOR CONFIGURATION
The invention concerns a method for detecting fluid (12) parameters (3) using a sensor configuration (2) of a flow meter (1), comprising: a) flowing training fluids (4) with known fluid parameters through the flow meter, wherein training measurement signals (5) from the sensor configuration are fed to a machine learning model (6); b) training the machine learning model to use real-time measurement signals (7) from the sensor configuration to detect real-time fluid (12) parameters (8); and c) using the trained machine learning model and real-time measurement signals fed to the trained machine learning model, to detect real-time fluid parameters, wherein feeding the real-time measurement signals from the sensor configuration to the machine learning model comprises processing (9) the real-time measurement signals by performing feature extraction or feature learning (10) thereon and feeding the processed real-time measurement signals (19) to the trained machine learning model.
G01N 9/32 - Investigating density or specific gravity of materialsAnalysing materials by determining density or specific gravity by using flow properties of fluids, e.g. flow through tubes or apertures
11.
AN ABERRATION COMPENSATING UNIT AND METHOD, AND A LIGHT OPTICAL DEVICE COMPRISING SUCH A UNIT.
The invention relates to an aberration compensating unit, a light optical device comprising such an aberration compensating unit, and a method for providing an aberration compensation or correction in such a light optical device. The aberration compensating unit comprises a series arrangement of a spatial light modulator and a multi-focus element. The multi-focus element is configured to focus light from the spatial light modulator into an arrangement of multiple foci distributed over a focus plane of the multi-focus element. In the light optical device, the aberration compensating unit is arranged in an optical path of the light optical device between a light source and an objective lens. Both the spatial light modulator and the multi-focus element are configured for providing an at least partial compensation or correction of one or more of the optical components in the light optical device.
B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
12.
AMMONIUM POLYPHOSPHATE LOADED PARTICLES AS A FLAME RETARDANT IN POLYMER COMPOSITIONS
The present invention relates to particles comprising a core comprising a water soluble flame retardant, such as ammonium polyphosphate and a shell comprising polyphenols, such as lignosulfonates. These particles may be used as flame retardants, in particular in polymer foams.
C08J 9/12 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
The present invention relates to particles comprising a core comprising a water-soluble ammonium polyphosphate and a shell comprising polyphenols, and to the use of these particles as flame retardants, in particular in polyurethane foams.
C08J 9/12 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
The present disclosure relates to a magnetic field inductor for navigating and positioning a magnetic manipulation element in a clinical environment. The magnetic field inductor including an electromagnetic coil for generating a magnetic field, the electromagnetic coil comprising at least one conductive element, for instance a copper wire, wound in a plurality of windings around a core extending in axial direction, thereby providing an outer circumferential coil element surface. The magnetic field inductor including a conduit assembly, including at least one fluid conduit for carrying a fluid coolant, the at least one fluid conduit being arranged in a pattern around the outer circumferential coil element surface of the electromagnetic coil and being configured to be in thermally conductive contact with the outer circumferential coil element surface in order to allow conduction of heat between the at least one conductive element and fluid coolant in the at least one fluid conduit.
The invention provides a system (1) to provide life support comprising an ambulatory system (1000) comprising an extracorporeal membrane oxygenation system (200), a mobile gas supply (500), and a mobile frame (100), wherein the extracorporeal membrane oxygenation system (200) comprises (i) a rechargeable power supply (300), (ii) an oxygenator (210), and (iii) a heat exchanger (1400) for controlling a temperature of a blood (2210) flowing through the extracorporeal membrane oxygenation system (200), wherein the system (1) is configured for operating in an ambulatory mode and for operating in a stationary mode; wherein in the ambulatory mode (i) the temperature control fluid inlet (1421) and the temperature control fluid outlet (1422) are closed, (ii) the rechargeable power supply (300) provides the power for (or to) the extracorporeal membrane oxygenation system (200), and (iii) the mobile gas supply (500) is fluidically coupled to the oxygenator (210)); and wherein in the stationary mode (i) a stationary temperature control fluid supply (450) is coupled to the temperature control fluid inlet (1421) and a stationary temperature control fluid discharge (460) is coupled to the temperature control fluid outlet (1422), (ii) a stationary power supply (1300) is coupled to the extracorporeal membrane oxygenation system (200), and (iii) a stationary gas supply (1500) is fluidically coupled to the oxygenator (210).
A61M 5/30 - Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or cartridges
A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
18.
THERMAL FLOW SENSOR FOR DETERMINING A FLOW RATE OF A FLUID
The invention relates to a thermal flow sensor (2) for determining a flow rate of a fluid (1), comprising: - a sensor body (11) with a flow section (12), through which fluid flows (3) in a flow direction during use, - a flow sensor configuration (13), comprising multiple flow sensing elements (14), such as two or three, arranged at multiple locations in the flow section for measuring the flow velocity at different locations in the flow section, wherein the multiple flow sensing elements (14) are arranged parallel to each other in a plane parallel to the flow section, and wherein single flow sensing elements (14) of the multiple flow sensing elements (14) can be read out.
The invention relates to a method for determining a flow rate of a fluid (1) independent of the physical properties of the fluid comprising: placing a thermal flow sensor (2) in thermal contact with a fluid flow (3); measuring flow rate; placing a thermal property sensor (4) in a measurement cavity (5) in fluidic contact with the fluid flow, wherein the measurement cavity is fully open to the fluid flow; receiving a portion (6) of the fluid in the measurement cavity of the thermal property sensor, in such a way, that the portion of the fluid is essentially stationary in the measurement cavity; measuring at least one thermal property (K, pep) of the fluid; and compensating the measured flow rate for the at least one measured thermal property.
42 44, an aluminum phyllosilicate material for use in the same, and an adsorbent comprising the aluminum phyllosilicate material. The aluminum phyllosilicate material is characterized by the intercalating moieties and basal spacing, allowing the selectivity in adsorption.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
The present invention relates to a light source for generating an optical frequency comb. The present invention further relates to a method for manufacturing the optical resonator used in this light source. The present invention additionally relates to microelectromechanical systems, MEMS, optical switch and system comprising the same. The present invention also relates to a sensor and to a method for manufacturing a suspended silicon nitride structure comprised in the sensor. According to the present invention, a single-step LPCVD deposited monolithic stoichiometric Si3N4 layer is used on a mono-crystalline aluminum oxide substrate such as sapphire. The thickness of the Si3N4 layer exceeds 500 nm. This layer can be realized with relatively low residual stress.
The application concerns a method for manufacturing an optical waveguide. The method comprising providing a substrate, depositing an aluminium oxide waveguide core on the substrate, and arranging a cladding layer on the deposited aluminium oxide waveguide core. The arranging comprising at least one processing step during which the deposited aluminium oxide waveguide core is subjected to a given maximum temperature. The method is characterized in that depositing the aluminium oxide waveguide core comprises forming nano-crystallites in the aluminium oxide waveguide core, and that the temperature the aluminium oxide waveguide core would be required to have for significantly increasing a size of the formed nano¬ crystallites during arranging of the cladding layer exceeds the given maximum temperature, wherein the given maximum temperature is about 800 degrees Celsius or higher.
G02B 6/132 - Integrated optical circuits characterised by the manufacturing method by deposition of thin films
G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
24.
METHOD FOR MANUFACTURING AN ALUMINIUM NITRIDE OPTICAL WAVEGUIDE, AND ALUMINIUM NITRIDE OPTICAL WAVEGUIDE
characterised in thatcharacterised in that depositing the aluminium nitride waveguide core comprises forming nano-crystallites in the aluminium nitride waveguide core, and in that the temperature the aluminium nitride waveguide core would be required to have for significantly increasing a size of the formed nano-crystallites during arranging of the cladding layer exceeds the given maximum temperature, wherein the given maximum temperature is about 800 degrees Celsius or higher.
G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
G02B 6/132 - Integrated optical circuits characterised by the manufacturing method by deposition of thin films
C23C 14/00 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
13 ABSTRACT The invention relates to a continuum manipulator, including an elongated body defining a virtual axis extending in a longitudinal direction. The elongated body includes at least two magnets, distributed along the virtual axis and arranged such that the magnetic fields of these two magnets 5 are oriented along the virtual axis, at least one flexible segment, each arranged in between two neighboring magnets and having a length defining a distance between two neighboring magnets. Wherein a resilience of the at least one segment and the mutual attractive force active over the distance between the two neighboring magnets are configured such that the elongated body is predisposed to flex under influence of an externally applied first magnetic field comprising a 10 constant component transverse to the magnetic fields of the at least two magnets, and to stretch out in the longitudinal direction in the absence of the first externally applied magnetic field. [Fig. 1.] 15
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
26.
METHOD AND SYSTEM FOR FORMING MICRO-CAPSULES COMPRISING A CORE SURROUNDED BY A SHELL
A system for forming micro-capsules comprising a core surrounded by a shell comprises a liquid container (1) and jet means (30) for generating and maintaining a liquid jet. The liquid container is connected to supply means (10,15) for supplying a shell liquid to a fill level of said container. The container is bound by a wall (4) having at least one opening (5) below said fill level that is substantially leak-free to said shell liquid. The jet means are connected to a liquid source (20,25) for supplying a liquid flow of a core liquid and comprise a nozzle (30) for ejecting a jet of said core liquid along a jet propagation path (35). The nozzle opens below said fill level (2) within said container at a distance from said opening (5) and is directed to said opening such that said jet propagation path crosses said opening.
The present invention relates to device for detecting at least one target nucleic acid sequence. The device comprises a surface which carries at least one activatable protein which is activated in the presence of the at least one target nucleic acid sequence; one or more reporter constructs which provide a detectable signal upon activation of the activatable protein, wherein the at least one activatable protein and/or the one or more reporter constructs are immobilized, optionally via a linker, to one or more moieties capable of moving along the surface.
The present invention relates to a method for determining CpG methylation of at least one target nucleic acid sequence in a liquid sample, the method comprising a) providing a liquid sample comprising molecules of the at least one target nucleic acid sequence; b) dividing the liquid sample into a plurality of liquid partitions; c) contacting the liquid sample of step a) and/or the liquid partitions of step b) with at least one methylation-sensitive restriction enzyme (MSRE); d) determining proportion of molecules of the at least one target nucleic acid sequence comprising at least one methylated CpG site by detecting proportion of liquid partitions comprising non-restricted molecules of the at least one target nucleic acid sequence and/or detecting proportion of liquid partitions comprising fragments of molecules of the at least one target nucleic acid sequence. The present invention also relates to a kit suitable for performing the method.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
The present invention relates to an optical detector and to an optical detection method. The present invention further relates to an optical sensor and to a method for detecting the quantity and/or presence of a specific molecules in a fluid. The optical detector of the present invention comprises a cascaded optical ring resonator (25A,25B) and is characterized in that the processing unit (5) used for processing the detector signal is configured to obtain transform, T, data by performing a first transform on the detector signal, to select respective T data for each of the closed-loop optical waveguides among the T data, and to perform a second transform being an inverse of the first transform on the selected respective T data for each of the closed-loop optical waveguides, wherein the first transform is configured for transforming data in the time domain to data in the frequency domain.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
G01N 21/53 - Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
30.
MRI COMPATIBLE ROBOTIC DEVICE FOR ABLATION TREATMENT
MRI compatible robotic device for Ablation Treatment, wherein said robotic device comprises: - a base member for placement on an outer skin surface of a human body; - a needle holding member for holding at least two needles; - a positioning system for moving the needle holding member with respect to the base member in at least two degrees of freedom for positioning the at least two needles at any orientation and at any location within an area of the outer skin surface of the human body that is covered by the robotic device.
A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
A system comprising a body wearable unit, with one or more cameras, a control system, and an electrical power source and a method for generating wearer data using the system, wherein the method comprises monitoring with one or more cameras a user wearing the wearable unit and providing a related camera signal; generating wearer data based on the related camera signal, wherein the wearer data comprise one or more of (i) wearer posture related data and (ii) wearer movement related data.
A43B 3/44 - Footwear characterised by the shape or the use with electrical or electronic arrangements with sensors, e.g. for detecting contact or position
32.
KEY HOLDER FOR AN OPTICAL KEY AND SYSTEM COMPRISING THE KEY HOLDER FOR AUTHENTICATING AN OPTICAL KEY BY VERIFYING A MATCH OF CHALLENGE-RESPONSE PAIRS
A key holder includes a ferrule, a multimode light guide at least partly embedded inside the ferrule, an optical key which has a light scattering material, and a mechanical mount which mounts each of the ferrule, the multimode light guide, and the optical key. The multimode light guide has a front facet and a back facet which are arranged at opposite ends. The back facet of the multimode light guide contacts the optical key. Light can enter into the multimode light guide via the front facet, propagate through the multimode light guide, be scattered by the optical key, and propagate back through the multimode light guide and exit via the front facet. The mechanical mount is detachably connected to a mechanical mount terminator. The front facet of the multimode light guide is oriented in a direction of the mechanical mount terminator.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
G02B 6/38 - Mechanical coupling means having fibre to fibre mating means
A system for additive manufacturing of a product from an electrically conductive depositable material. The system comprises a support element, a material addition system, and two electrodes. The support element supports the product, wherein the two electrodes comprise electrodes configured at a surface of the support element. The material addition system deposits the material at one or more of (i) the support element and (ii) deposited material, thereby forming the product. Any one of the electrodes is configured for (i) electrically contacting the material being deposited or (ii) electrically contacting the deposited material, during depositing of the material. (i) the material is deposited with a portion of the deposited material and arranged between the electrode and another one of the electrodes to define an electrically conductive path. Alternatively, (ii) a portion of the deposited material is arranged between the electrode and another one of the electrodes to define the electrically conductive path.
The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
Disclosed is a handheld laser-based perfusion imaging apparatus having a light source and an imaging device which are arranged in a fixed orientation to each other in the apparatus. The light source is configured for projecting a beam of coherent light onto a measurement field at a predetermined distance spaced apart from the apparatus. The imaging device is configured for recording speckle intensity maps of the measurement field and/or images of Doppler shifted light of the measurement field. The light source is configured to provide a substantially spherical wavefront or a substantial planar wavefront, at least at the measurement field. Preferably, the apparatus with the light source that provides a substantial planar wavefront, including a gimbal mount. Also disclosed is a method for measuring a perfusion in a tissue using the handheld laser-based perfusion imaging apparatus as described above.
A method and system for concentrating an analyte (A). Liquid droplets (D) of an extractant liquid (Le) are adhered to a wall (10w) of a container, e.g. capillary tube. A sample fluid (Fs) comprising the analyte (A) is provided in the container (10) to contact the liquid droplets (D). The analyte (A) has a higher solubility in the liquid droplets (D) than in the sample fluid (Fs). This causes the analyte (A) to be extracted from the sample fluid (Fs) and concentrated in the liquid droplets (D). After extraction, the liquid droplets (D) are collected, e.g. scraped, from the wall (10w) for obtaining the concentrated analyte (A). A concentrated liquid (La) can be formed by collecting the liquid droplets (D) from the wall (10w). The analyte (A) can be measured in the concentrated liquid (La) using any suitable measurement technique.
A pump configured to pump a magnetic mixture in a flow direction. The pump comprises a channel comprising an ascending portion and a descending portion and a magnetic field generating unit, arranged adjacent to and at least partially enclosing adjoining sections of the ascending portion and the descending portion. The magnetic field generating unit generates a magnetic field varies a magnetic field strength of the magnetic field between a first average field strength, and a second average field strength, lower than the first average field strength, such that: - when the magnetic field has the first average field strength, a first volume of the magnetic mixture present in the ascending portion of the channel is urged to flow in the flow direction, from the ascending portion into the descending portion, and, - when the magnetic field strength is lowered to the second average field strength, the first volume of magnetic mixture present in the enclosed section of the descending portion is allowed, under the influence of gravity, to flow in the flow direction, out of, and thereby at least partially draining the enclosed section of the descending portion.
The invention provides a method for subcooling a cryogenic liquid (1), the method comprising providing a discharge element (2) comprising a first discharge element portion (23) comprising (i) a discharge element inlet opening (21), (ii) a throttle element (25), and (iii) a heat conductive wall (28); providing a cryogenic liquid (1) in an open container (10); immersing the first discharge element portion (23) in the cryogenic liquid (1) in the open container (10); and reducing a pressure in the discharge element (20) at a downstream side (26) of the throttle element (25), thereby inducing a flow of the cryogenic liquid (1) from an upstream side (24) of the throttle element (25) through the throttle element (25), wherein at least part of the cryogenic liquid (1) changes phase at the downstream side (26) of the throttle element (25), thereby providing a heat flow from the cryogenic liquid (1) surrounding the discharge element (20) to the first discharge element portion (23).
KOREA INSTIITUTE OF MEDICAL MICROROBOTICS (Republic of Korea)
INDUSTRY FOUNDATION OF CHONNAM NATIONAL (Republic of Korea)
Inventor
Alaa Eldin Adel Mohamed Mahmoud, Sadek
Mina Maged Michael, Farag
Sarthak, Misra
Islam S. M., Khalil
Park, Jong Oh
Kim, Chang Sei
Abstract
The invention relates to a spherical electromagnetic actuator. The spherical electromagnetic actuator including a spherical permanent magnet having a center region, a housing comprising a chamber enclosing the spherical magnet and having an inlet for receiving a fluid. The actuator further including three electromagnetic coil assemblies with each coil assembly having at least one coil and a virtual symmetry axis, and wherein the three electromagnetic coil assemblies are arranged such that the three respective symmetry axes intersect at a center region the spherical permanent magnet. The housing is arranged such that in operation the fluid causes the spherical magnet to levitate. And, in operation, the three electromagnetic coil assemblies provide a superpositioned magnetic field manipulating the orientation of the spherical magnet. The invention further relates to a method for controlling the magnetic field of at least one spherical magnetic actuator.
H02K 26/00 - Machines adapted to function as torque motors, i.e. to exert a torque when stalled
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
H02K 41/03 - Synchronous motorsMotors moving step by stepReluctance motors
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
H02K 11/215 - Magnetic effect devices, e.g. Hall-effect or magneto-resistive elements
H02K 11/25 - Devices for sensing temperature, or actuated thereby
H02K 11/27 - Devices for sensing current, or actuated thereby
H02K 11/30 - Structural association with control circuits or drive circuits
The present invention relates to use of a P-containing polymer for measuring 31P-MRI, wherein the P-containing polymer is selected from polyphosphates, polyphosphonates, poly(phosphine oxide)s, polyphosphazenes, polyphosphinates, polyphosphoramidates, polyphosphorodiamidates, polyphosphoamides, polythionophosphates, and polythionophosphonates. The invention furthermore relates to a polyphosphonate copolymer and an aqueous suspension comprising micelles of the polyphosphonate copolymer.
A method for determining a scaled respiratory flow rate and volume during respiration of a patient includes a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure, b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship, c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship, and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation. Step a) is performed during tidal breathing of the patient. A system for performing the aforementioned method.
INSTITUT HOSPITALO-UNIVERSITAIRE DE STRASBOURG (France)
UNIVERSITEIT TWENTE (Netherlands)
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
Inventor
Stramigioli, Stefano
Cotin, Stéphane
Van As, David
Bessard Duparc, Rémi
Perretta, Silvana
Abstract
Disclosed is a device for simulating the movement of an endoscope in an environment, including: a tube modelling an endoscope tube; and a tracking module including a housing into which the tube is insertable and movable. The tracking module includes a detector of movements of the tube in the housing and a unit for communicating the detected movements to a controller. The controller is configured to generate, at each instant, an image of a portion of an environment based on the movements of the tube detected by the detector so as to simulate the movement of an endoscope in the environment. The tracking module includes a fastener adapted to fasten the tracking module in a releasable manner onto a support.
A method for monitoring a system for injecting heated air into a patient. The system includes a source of air, a device for heating the air, a cannula for insertion into nostrils of the patient, a first conduit interconnecting the source and the device, and a second conduit interconnecting the device and the cannula. The method includes deriving pressure in the cannula from pressure of the air between the source and the cannula. The method includes measuring a pressure of the air at between the source and the cannula, determining a flow rate of the air in the system, deriving a first function representative of a respiratory flow rate of the patient from the measured pressure and the system air flow rate, deriving a second function representative of a respiratory volume of the patient from the measured pressure and the system air flow rate, and graphically displaying the functions.
The present invention provides a method for separating high-methylated DNA and low- methylated DNA, the method comprising a) providing a liquid sample comprising high- methylated DNA and low-methylated DNA; b) contacting the sample with a surface to which MBD2 proteins are immobilized to allow formation of MBD2-high-methylated DNA complexes on said surface, thereby separating high-methylated DNA and low-methylated DNA. The sample may be a body fluid, preferably a urine sample or a blood plasma sample.
The invention relates to an apparatus and a method for producing a high aspect ratio surface structures on a surface of a substrate. The method comprises the steps of: providing a transfer member, wherein the transfer member extends in a first direction and has a width substantially perpendicular to the first direction, providing a layer of a substance onto the transfer member, wherein the substance and/or the transfer member is/are configured so that there is an adhesion between them, at least partially transferring the substance from the transfer member onto the surface of the substrate by: moving the transfer member and/or the substrate so that the transfer member and the substrate move towards each other until at least the substance contacts the surface of the substrate, and moving the transfer member and/or the substrate so that the transfer member and the substrate move away from each other.
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
A method of printing a cellular solid by direct bubble writing comprises introducing an ink formulation comprising a polymerizable monomer and a gas into a nozzle, which includes a core flow channel radially surrounded by an outer flow channel. The ink formulation is directed into the outer flow channel and the gas is directed into the core flow channel. The ink formulation and the gas are ejected out of the nozzle as a stream of bubbles, where each bubble includes a core comprising the gas and a liquid shell overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell from the liquid shell, and the bubbles are deposited on a substrate moving relative to the nozzle. Thus, a polymeric cellular solid having a predetermined geometry is printed.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/188 - Processes of additive manufacturing involving additional operations performed on the added layers, e.g. smoothing, grinding or thickness control
First and second novel membranes for use in a lithographic apparatus are disclosed. The first membrane comprises a core substrate and a metal silicate layer. The metal silicate layer is an outermost layer of the first membrane. The second membrane comprises a core substrate and an yttrium silicate layer. The yttrium silicate layer may be an outermost layer of the membrane or, alternatively, the yttrium silicate layer may be disposed between the core substrate and a layer of yttrium or yttrium oxide. The first and second membranes may be provided within an EUV lithographic apparatus. For example, the membranes may form part of a pellicle. The pellicle may be suitable for use adjacent to a reticle within an EUV lithographic apparatus. Alternatively, the membranes may form part of a dynamic gas lock. Alternatively, the membranes may form part of a spectral filter.
The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: —Providing input signals, —Using said input signals as input variables of a musculoskeletal model, —Determining feedback signals using said musculoskeletal model, —Transmitting said feedback signals to said user of said orthopedic device.
The invention provides a method for determining a property of a target area (15) of a material (10), wherein the target area (15) has a size selected from the range of 100 μm2− 100 mm2, wherein the method comprises: an exposure stage comprising providing a liquid jet (20) to the target area (15), wherein the liquid jet (20) has a jet velocity selected from the range of 2 − 150 m/s; a measurement stage comprising detecting a deformation (16) of the material in the target area (15) and providing a related signal; and an analysis stage comprising determining the property of the target area (15) based on the related signal.
Ente Ospedaliero Specializzato in Gastroenterologia "Saverio De Bellis" - IRCCS (Italy)
Inventor
Susarrey Arce, Arturo
Krol, Silke Inge
Berenschot, Johan Willem
Tas, Niels Roelof
Abstract
The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.
The invention relates to a method and apparatus for detecting superparamagnetic material. The method comprises applying, by an excitation coil, a magnetic field during a first period to an object to modulate a magnetization of the superparamagnetic material, the magnetic field comprising a first component with a first frequency; positioning a sensing device at a first position from the excitation coil receiving a first signal by a first detection sub-coil in the sensing device and a second signal by a second detection-sub-coil in the sensing device; determining a sensor signal from the first signal and the second signal; determining a detection signal based on the sensor signal; determining a parameter indicating an amount of superparamagnetic material by dividing the detection signal by the first signal, and repeating steps to at at least one different position in order to determine a location where the parameter has a maximal value.
The invention relates to methods for producing a device comprising a plurality of three-dimensional structures. In particular, the invention relates to methods for producing a device comprising a plurality of three-dimensional structures comprising electrodes, in particular three-dimensional electrodes. The invention further relates to uses device comprising a plurality of three-dimensional structures, uses thereof and to methods for culturing cells using such device.
19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.
The present invention relates to a motor system, a stepper motor and a rotor therefor. More in particular, the present invention relates to detecting, in a motor system, an angular position of a rotor of an electric stepper motor. The motor system according to the present invention comprises: a stepper motor, the stepper motor comprising a stator and a rotor, wherein the stator comprises a cavity in which the rotor is arranged, and a plurality of stator coils arranged around a circumference of the cavity, the plurality of stator coils being configured to drive the rotor to rotate in a rotational direction, and wherein the rotor comprises a rotor body having a plurality of rotor poles that are irregularly spaced along a circumference of the rotor body; a driving unit configured to drive each stator coil using a respective driving signal to thereby cause the rotor to rotate; and a position determining unit. The position determining unit is configured to, while the rotor is rotating: measure a current through one or more stator coils among the plurality of stator coils, each current comprising a superposition of at least a driving current as a result of driving a corresponding stator coil and an induced current resulting from a changing magnetic flux through said corresponding stator coil due to the rotating rotor; and determine an angular position of the rotor based on the measured current(s) and a known spacing between the plurality of rotor poles.
H02K 11/21 - Devices for sensing speed or position, or actuated thereby
H02K 11/27 - Devices for sensing current, or actuated thereby
H02K 37/14 - Motors with rotor rotating step by step and without interrupter or commutator driven by the rotor, e.g. stepping motors of permanent magnet type with stationary armatures and rotating magnets with magnets rotating within the armatures
55.
TIME-DOMAIN PHYSICAL UNCLONABLE KEY (TPUK) AUTHENTICATED COMMUNICATION
A method for a PUK authenticated communication includes creating an optical challenge in a time-frequency domain, providing the optical challenge to a tPUK which includes a spatial input channel and a plurality of spatial output channels, and detecting in which of the plurality of spatial output channels a short temporally focused pulse is created. The tPUK provides a complex challenge-response behavior in the time-frequency domain. The optical challenge is created so that the tPUK creates the response having a short temporally focused pulse in only one of the plurality of spatial output channels of the tPUK.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
A fluidic device for processing a fluid or species therein is described. The device comprises a 3D channel including an inlet for receiving a sample fluid and an outlet for outputting the sample fluid. The channel is adapted for guiding flow of the sample fluid in an axial direction from the inlet to the outlet. The channel includes at least two side walls. The device also has a controllable flow inducer having electrodes for inducing, when the sample fluid is flowing through the channel, a motion of the sample fluid in the channel in a plane substantially orthogonal to the axial direction. Along at least one of the side walls at least part of the electrodes are formed by alternatingly at least an electrically conducting portion, an electrically insulating portion and a further electrically conducting portion.
A photovoltaic solar power plant assembly and a method of using said assembly to generate power are disclosed. The assembly includes an array of photovoltaic solar modules arranged in a solar module surface, and an optical structure for redirecting light towards said solar module surface, having a redirected light emitting surface. The optical structure includes: a planar optical waveguide which has a parallel first and second planar waveguide surfaces, wherein the first planar waveguide surface extends parallel to the redirected light emitting surface, wherein the first planar waveguide surface is at least partially covered by a photonic layer which is configured to provide an angular restriction of a light emission from the planar waveguide through the redirected light emitting surface, and a light scattering and/or luminescent material, which material is arranged as particles in the planar optical waveguide and/or in a layer which at least partially covers the second planar waveguide surface.
Stichting voor de Technische Wetenschappen (Netherlands)
UMC Utrecht Holding B.V. (Netherlands)
Universiteit Utrecht Holding B.V. (Netherlands)
Universiteit Twente (Netherlands)
Inventor
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Guo, Yong
Abstract
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
The invention provides a construct (1) comprising a number N of material types (100, 110, . . . ), wherein N is at least 2, wherein at least two of the material types (100, 110, . . . ) comprise granular material (101) comprising particles (10), wherein the granular material (101) at least defines an exterior surface (6) of the construct (1), wherein the construct (1) is self-supporting, and wherein the construct (1) is (i) self-healing or is (ii) configured for being self-healing by changing a liquid (15) content of the construct (1); wherein the different material types (100, 110, . . . ) mutually differ in at least one characteristic (19) selected from the group consisting of a physical characteristic and a chemical characteristic.
A friction stir extrusion apparatus for extruding material, comprising a housing, a transport screw and a feeder, the housing comprising a body with a round cavity and extending along a rotational axis and having an input opening for a material feed and an output opening for extruded material; the transport screw having helical ridges along its length is arranged within the cavity and adapted for rotating inside the cavity; the feeder adapted for feeding the material feed to the input opening, wherein a first portion of the cavity is tapered towards the output opening and the transport screw is tapered along the first portion of the cavity, and a gap between a major diameter of the helical ridge of the transport screw and the inner wall of the cavity is constant and non-zero along the first portion.
B23K 20/12 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating the heat being generated by frictionFriction welding
B29C 48/02 - Small extruding apparatus, e.g. handheld, toy or laboratory extruders
B29C 48/25 - Component parts, details or accessoriesAuxiliary operations
B29C 48/395 - Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
G02F 1/355 - Non-linear optics characterised by the materials used
G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
62.
METHOD FOR FORMING A BOND BETWEEN TWO SUBSTRATES OF A DEVICE; DEVICE OBTAINABLE BY THE METHOD; A MICROFLUIDIC DEVICE; AND USE OF THE DEVICE
Provided is a method for forming a bond between two substrates of a device, comprising the steps of: providing a first substrate and a second substrate of a device; providing a first functionalized polyelectrolyte polymer (A) comprising a plurality of electrolyte repeating units, wherein at least one of the electrolyte repeating units is a functionalized repeating unit (G1) comprising a first functional group comprising a first coupling moiety (A1); providing a second functionalized polyelectrolyte polymer (B) comprising a plurality of electrolyte repeating units, wherein at least one of the electrolyte repeating units is a functionalized repeating unit (G2) comprising a second functional group comprising a second coupling moiety (B1); wherein the second coupling moiety (B1) is selected to be complementary for forming a covalent bond to the first coupling moiety (A1) at a temperature below 100ºC; forming a functionalized surface on an exposed surface of the first substrate having the first functionalized polyelectrolyte polymer (A) attached to said first substrate; forming a functionalized surface on an exposed surface of the second substrate having the second functionalized polyelectrolyte polymer (B) attached to said second substrate; contacting at least a part of the functionalized surface of the first substrate onto at least a part of the functionalized surface of the second substrate thereby forming a contact area between the first functionalized polyelectrolyte polymer (A) and the second functionalized polyelectrolyte polymer (B); and forming a covalent bond between the first coupling moiety (A1) and the second coupling moiety (B1) in the contact area between the first substrate and the second substrate for binding the first substrate to the second substrate.
C09J 5/02 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving pretreatment of the surfaces to be joined
63.
ADDITIVE MANUFACTURING OF THERMOPLASTIC COMPOSITES AT AMBIENT CONDITIONS
A method for creating a thermoplastic element by additive manufacturing is presented which includes the steps of: a) providing a resin mixture that at least includes a resin and at least one photo-initiator species in which the resin mixture is liquid at substantially room temperature; b) curing the resin mixture at substantially room temperature using UV-light. The resin mixture for use in the method for manufacturing a thermoplastic element, is substantially liquid at room temperature, and includes at least one photo-initiator species. A device for manufacturing a thermoplastic element is presented that at least includes a preferably moveable nozzle for extruding the resin mixture and a UV-light source arranged at or near an outlet of the nozzle for curing the extruded resin mixture.
The invention relates to a pressure driven microfluidic chip for delivering a first liquid at a determined flow rate, said chip comprising a first inlet, a container connected to the first inlet, a second inlet connected to the container via a first passage, a second passage connecting the container to an outlet, wherein the first passage has a first resistance to liquid flow, and the second passage has a second resistance to liquid flow. The first resistance may be higher than the second resistance. The invention also relates to a pressure driven method of delivering a first liquid at a determined flow rate comprising using a chip first a first and second passage, wherein the first passage has a first resistance to the flow of the first liquid, and the second passage has a second resistance to flow of the second liquid.
The invention relates to a handheld laser-based perfusion imaging apparatus comprising a light source and an imaging device which are arranged in a fixed orientation to each other in said apparatus. The light source is configured for projecting a beam of coherent light onto a measurement field at a predetermined distance spaced apart from the apparatus. The imaging device is configured for recording speckle intensity maps of the measurement field and/or images of Doppler shifted light of the measurement field. The light source is configured to provide a substantially spherical wavefront or a substantial planar wavefront, at least at the measurement field. Preferably, the apparatus with the light source that provides a substantial planar wavefront, comprises a gimbal mount. Furthermore, the invention relates to a method for measuring a perfusion in a tissue using the handheld laser-based perfusion imaging apparatus as described above.
The invention provides a system (1) comprising a body wearable unit (1000), with one or more cameras (200), a control system (300), and an electrical power source (400). The invention further provides a method for generating wearer data using the system (1), wherein the method comprises monitoring with one or more cameras (200) a user wearing the wearable unit (1000) and providing a related camera signal; generating wearer data based on the related camera signal, wherein the wearer data comprise one or more of (i) wearer posture related data and (ii) wearer movement related data.
A method and system for concentrating an analyte (A). Liquid droplets (D) of an extractant liquid (Le) are adhered to a wall (10w) of a container, e.g. capillary tube. A sample fluid (Fs) comprising the analyte (A) is provided in the container (10) to contact the liquid droplets (D). The analyte (A) has a higher solubility in the liquid droplets (D) than in the sample fluid (Fs). This causes the analyte (A) to be extracted from the sample fluid (Fs) and concentrated in the liquid droplets (D). After extraction, the liquid droplets (D) are collected, e.g. scraped, from the wall (10w) for obtaining the concentrated analyte (A). A concentrated liquid (La) can be formed by collecting the liquid droplets (D) from the wall (10w). The analyte (A) can be measured in the concentrated liquid (La) using any suitable measurement technique.
Key holder (1) comprising: a ferrule (2); a multimode light guide (3), in particular a multimode fiber piece (3), at least partly embedded inside the ferrule (2); an optical key (4) comprising a light scattering material; and a mechanical mount (5) mounting the ferrule (2), the multimode light guide (3) and the optical key (4), wherein the multimode light guide (3) comprises a front facet (6) and a back facet (7) provided at opposite ends of the multimode light guide (3) and wherein the back facet (7) of the multimode light guide (3) contacts the optical key (4), wherein the multimode light guide (3) is adapted in such a way that light can enter into the multimode fiber piece (3) via the front facet (6), propagate through the multimode fiber piece (3) in particular via total internal reflection, be scattered by the optical key (4), and propagate back through the multimode light guide (3) and exit via the front facet (6), and wherein the mechanical mount (5) is adapted to be detachably connected to a mechanical mount terminator (50), wherein the front facet (6) of the multimode light guide (3) is oriented in the direction of the mechanical mount terminator (50).
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
G02B 6/38 - Mechanical coupling means having fibre to fibre mating means
G09C 5/00 - Ciphering or deciphering apparatus or methods not provided for in other groups of this subclass, e.g. involving the concealment or deformation of graphic data such as designs, written or printed messages
A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: —the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5-400 μm, a chamber width we selected from the range of 2hc-10hc, and a chamber length lc defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); —the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).
INSTITUT HOSPITALO-UNIVERSITAIRE DE STRASBOURG (France)
UNIVERSITEIT TWENTE (Netherlands)
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
Inventor
Stramigioli, Stefano
Cotin, Stéphane
Van As, David
Bessard Duparc, Rémi
Perretta, Silvana
Abstract
The present invention relates to a device (10) for simulating the movement of an endoscope in an environment, comprising. a. a tube modelling an endoscope tube, b. a tracking module (14) comprising a housing (29) into which the tube (22) is insertable and movable, the tracking module (14) comprising means (30) for detecting movements of the tube in the housing and means for communicating the detected movements to a controller (16), the controller (16) being configured to generate, at each instant, an image of a portion of an environment based on the movements of the tube (22) detected by the detecting means (30) so as to simulate the movement of an endoscope in the environment, characterized in that the tracking module (14) comprises fastening means adapted to fasten the tracking module (14) in a releasable manner onto a support.
The invention relates to a method for determining a scaled respiratory flow rate and volume during respiration of a patient, comprising the steps of: a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure; b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship; c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship; and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation wherein step a) is performed during tidal breathing of the patient. The invention further relates to a system for performing this method.
A method for monitoring a system for injecting heated air into a patient is disclosed, wherein the system includes a source of air, a device for heating the air, a cannula for insertion into nostrils of the patient, a first conduit interconnecting the source and the device, and a second conduit interconnecting the device and the cannula. The method comprises deriving a pressure in the cannula from a pressure of the air measured at the first location between the source and the cannula. Additionally or alternatively, the method may comprise the steps of: - continuously or periodically measuring a pressure of the air at a first location between the source and the cannula, - determining a flow rate of the air in the system, - deriving a first function representative of a respiratory flow rate of the patient from the measured pressure and the system air flow rate, - deriving a second function representative of a respiratory volume of the patient from the measured pressure and the system air flow rate, and - displaying the first and second functions in a graphical representation. Also disclosed is an apparatus for performing this method.
The invention provides a system (1000) comprising a microfluidic device (1), wherein the microfluidic device (1) comprises a first side (2), a second side (3), a device plane (6) between the first side (2) and the second side (3), a first channel (100) having a first channel inlet (101) and a first channel outlet (102), a first side chamber (150) extending from the first channel (100) in a direction parallel to the device plane (6), a second channel (200), and a second side chamber (250) extending from the second channel (200) in a direction parallel to the device plane (6); wherein the second channel (200) in combination with the first channel (100) define a double-channel (10) with a double-channel axis (15); and wherein the first side chamber (150) is accessible via a first opening (151) either via the first side (2) or via the second side (3) and wherein the second side chamber (250) is accessible via a second opening (251) either via the first side (2) or via the second side (3).
The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: - Providing input signals, - Using said input signals as input variables of a musculoskeletal model, - Determining feedback signals using said musculoskeletal model, - Transmitting said feedback signals to said user of said orthopedic device.
ENTE OSPEDALIERO SPECIALIZZATO IN GASTROENTEROLOGIA "SAVERIO DE BELLIS" - IRCCS (Italy)
Inventor
Susarrey Arce, Arturo
Krol, Silke
Berenschot, Erwin
Tas, Niels
Abstract
The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.
ENTE OSPEDALIERO SPECIALIZZATO IN GASTROENTEROLOGIA "SAVERIO DE BELLIS" - IRCCS (Italy)
Inventor
Susarrey Arce, Arturo
Krol, Silke Inge
Berenschot, Johan Willem
Tas, Niels Roelof
Abstract
The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.
The invention relates to a method and apparatus for detecting superpara magnetic material. The method comprises applying, by an excitation coil, a magnetic field during a first period to an object to modulate a magnetization of the superpara magnetic material, the magnetic field comprising a first component with a first frequency; positioning a sensing device at a first position from the excitation coil receiving a first signal by a first detection sub-coil in the sensing device and a second signal by a second detection-sub-coil in the sensing device; determining a sensor signal from the first signal and the second signal; determining a detection signal based on the sensor signal; determining a parameter indicating an amount of superpara magnetic material by dividing the detection signal by the first signal, and repeating steps to at at least one different position in order to determine a location where the parameter has a maximal value.
G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
G01N 27/76 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids by investigating susceptibility
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
A61B 1/313 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
The present disclosure relates to a conductivity measuring system of a fluid including a solvent and an ionic solute, comprising: —a holder comprising an isolated holder wall defining a fluid channel for holding fluid, wherein the holder is shaped to allow an electrical current induced in the fluid to form a current loop; —an excitation device configured to excite an electric field inside a first part of the fluid channel, the excitation device comprising an electrical signal generator configured to generate an alternating current signal and a conducting slab; —a sensing device arranged at a position remote from the first part of the fluid channel and configured to sense a voltage signal (V) resulting from the changing magnetic field resulting from the current generated inside the fluid by the excitation device.
A fluidic device, in particular a microfluidic chip, for culturing a 3D cell culture comprises a bottom wall defining a bottom side of an open-top chamber arranged for containing a cell culture medium. A fluidic channel extends below the chamber between a channel inlet and a channel outlet for guiding a fluid flow. The bottom wall is provided with a micro-opening through which the chamber and the microfluidic channel are in fluid communication. A side wall extends from the bottom wall circumferentially around the chamber to a top wall opposite the bottom wall. An upper edge of the side wall delimits an open access upper side of the chamber and the top wall is arranged for closing the chamber at the upper side thereof and to be supported by the upper edge of the side wall. A sealing means is provided between opposing surfaces of the upper edge of the side wall and the top wall and arranged for reversible fluid sealing of the side wall and top wall when the chamber is closed at the upper side by the top wall.
A method of printing a cellular solid (120) by direct bubble writing comprises introducing an ink formulation (102) comprising a polymerizable monomer and a gas (104) into a nozzle (106), which includes a core flow channel (108) radially surrounded by an outer flow channel (110). The ink formulation is directed into the outer flow channel (110) and the gas is directed into the core flow channel (108). The ink formulation (102) and the gas (104) are ejected out of the nozzle (106) as a stream of bubbles (112), where each bubble includes a core (114) comprising the gas and a liquid shell (116) overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell (118) from the liquid shell (116), and the bubbles are deposited on a substrate (122) moving relative to the nozzle (106). Thus, a polymeric cellular solid (120) having a predetermined geometry is printed.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/236 - Driving means for motion in a direction within the plane of a layer
B29C 64/188 - Processes of additive manufacturing involving additional operations performed on the added layers, e.g. smoothing, grinding or thickness control
B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
B22F 12/00 - Apparatus or devices specially adapted for additive manufacturingAuxiliary means for additive manufacturingCombinations of additive manufacturing apparatus or devices with other processing apparatus or devices
81.
MAGNETIC FIELD GRADIENT APPARATUS AND APPARATUS FOR SEPARATION
The invention relates to a magnet apparatus for generating a magnetic field, the magnet apparatus comprising: at least three coils arranged besides each other along a first axis in a first plane, wherein each coil comprises a conductor comprising a material having superconducting properties at an operating temperature, the coils further comprise two legs and two bent end sections in the first plane, wherein a first and a second leg are arranged parallel to each other along a second axis in the first plane transverse to the first axis, and the two bent sections are arranged opposite to each other; and a controller arranged to control currents through the respective coils to obtain a current distribution in the first plane, wherein a current direction of the current distribution is alternating between opposite directions parallel to the second axis, with a period λ along the first axis. The invention also related to a magnetic density separation apparatus comprising the magnet apparatus.
H01F 27/42 - Circuits specially adapted for the purpose of modifying, or compensating for, electric characteristics of transformers, reactors or choke coils
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
82.
Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients
Disclosed are compositions for use in the simultaneous removal of endotoxins from dialysate and uremic solutes from blood during the treatment of patients. The treatment is selected from the group consisting of hemodialysis and hemodiafiltration. The compositions comprise sorbent particles embedded in a membrane comprising a polymer and a hydrophilic additive.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
B01D 71/62 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A fluidic device for processing a fluid or species therein is described. The device comprises a 3D channel comprising an inlet for receiving a sample fluid and an outlet for outputting the sample fluid. The channel is adapted for guiding flow of the sample fluid in an axial direction from the inlet to the outlet, the channel comprising at least two side walls. The device also comprises a controllable flow inducer comprising electrodes for inducing, when the sample fluid is flowing through the channel, a motion of the sample fluid in the channel in a plane substantially orthogonal to the axial direction. Along at least one of the side walls at least part of the electrodes are formed by alternatingly at least an electrically conducting portion, an electrically insulating portion and a further electrically conducting portion.
The present invention discloses a method and a system for PUK authenticated communication. The method comprises the following steps: creating an optical challenge (1) in a time- frequency domain; providing the optical challenge (1) to a tPUK (2) for creating a response, the tPUK (2) comprising a spatial input channel (3) and a plurality of spatial output channels (4) and the tPUK (2) comprising a complex challenge-response behavior in the time-frequency domain, wherein the challenge (1) is created such that in the response a short temporally focused pulse (7) is created in only one of the spatial output channels (4) of the tPUK (2); and detecting in which output channel (4) the short temporally focused pulse (7) is created.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
G09C 5/00 - Ciphering or deciphering apparatus or methods not provided for in other groups of this subclass, e.g. involving the concealment or deformation of graphic data such as designs, written or printed messages
85.
FOOT PROGRESSION ANGLE DETERMINATION METHOD AND SYSTEM, COMPUTER PROGRAM, AND STORAGE MEDIUM
In a method and system for determining a foot progression angle of a foot, an inertial sensor is connected to the foot. The method comprises a processing system performing the steps of: acquiring, from the sensor, angular velocity data and acceleration data in a sensor coordinate system; identifying, based on said data, a first zero-velocity phase and a subsequent second zero-velocity phase; and during a step of the foot: mapping the angular velocity to a foot coordinate system; integrating the angular velocity to obtain an orientation of the foot direction; mapping the acceleration to the foot coordinate system; subtracting the acceleration of gravity from the acceleration to obtain a corrected acceleration; integrating the corrected acceleration to obtain a linear velocity; integrating the linear velocity to obtain a foot position; and determining the foot progression angle between the orientation of the foot at the first zero-velocity phase or the second zero-velocity phase, and a stepping direction of the foot.
33 as transparent conductive oxide for various applications, by enabling it to be applied on arbitrary substrates. Furthermore, the transparent conductive oxide has favorable optical properties, such as transparency in the IR region.
H01L 31/0392 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their crystalline structure or particular orientation of the crystalline planes including thin films deposited on metallic or insulating substrates
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
A photodetector is provided for sensing radiation in middle and long wave infrared domain. The sensor has a sensor layer of a first material having a first conductivity type and a first permittivity in which the shortest distance of any point in the sensor layer to an adjacent layer having a second conductivity type and a second permittivity lower than the first permittivity is 20 nanometres or less. Conductivity type may be semiconductor n-type or p-type or insulator. If, for example, a silicon sensor layer is sandwiched between two silicon oxide layers, the sensor layer of preferably p-type semiconductor has a maximum thickness of 40 nanometres. If a p-type layer of a first material is sandwiched between a dielectric layer with the second permittivity and an n-type layer of the first material, the maximum thickness is 20 nanometres. Spaced apart, two contacts are provided in contact with the sensor layer.
H01L 31/0232 - Optical elements or arrangements associated with the device
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 31/09 - Devices sensitive to infrared, visible or ultra- violet radiation
88.
PHOTOVOLTAIC SOLAR POWER PLANT ASSEMBLY COMPRISING AN OPTICAL STRUCTURE FOR REDIRECTING LIGHT
The invention relates to a photovoltaic solar power plant assembly and a method of using said assembly to generate power. The assembly comprises an array of photovoltaic solar modules arranged in a solar module surface, and an optical structure for redirecting light towards said solar module surface, comprising a redirected light emitting surface. The optical structure comprises: a planar optical waveguide which comprises a parallel first and second planar waveguide surfaces, wherein said first planar waveguide surface extends parallel to said redirected light emitting surface, wherein said first planar waveguide surface is at least partially covered by a photonic layer which is configured to provide an angular restriction of a light emission from the planar waveguide through said redirected light emitting surface, and a light scattering and/or luminescent material, which material is arranged as particles in the planar optical waveguide and/or in a layer which at least partially covers said second planar waveguide surface.
H01L 31/055 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means where light is absorbed and re-emitted at a different wavelength by the optical element directly associated or integrated with the PV cell, e.g. by using luminescent material, fluorescent concentrators or up-conversion arrangements
H02S 40/22 - Light-reflecting or light-concentrating means
A USB communication port comprising a USB male connector (5) and a USB female connector (4) and equipped to transfer information between the USB male connector (5) and the USB female connector (4), wherein the USB male connector (5) is equipped with a first coupling portion and the USB female connector (4) is equipped with a second coupling portion, wherein the first coupling portion and the second coupling portion are arranged to wirelessly transfer data and/or electrical energy between the first coupling portion and the second coupling portion.
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (Netherlands)
Inventor
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Guo, Yong
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Abstract
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (Netherlands)
UMC UTRECHT HOLDING B.V. (Netherlands)
UNIVERSITEIT UTRECHT HOLDING B.V. (Netherlands)
UNIVERSITEIT TWENTE (Netherlands)
Inventor
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Guo, Yong
Abstract
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
The invention provides a construct (1) comprising a number N of material types (100, 110,...), wherein N is at least 2, wherein at least two of the material types (100, 110, …) comprise granular material (101) comprising particles (10), wherein the granular material (101) at least defines an exterior surface (6) of the construct (1), wherein the construct (1) is self-supporting, and wherein the construct (1) is (i) self-healing or is (ii) configured for being self-healing by changing a liquid (15) content of the construct (1); wherein the different material types (100, 110, …) mutually differ in at least one characteristic (19) selected from the group consisting of a physical characteristic and a chemical characteristic.
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (Netherlands)
UNIVERSITEIT TWENTE (Netherlands)
Inventor
Zhao, Yiyuan
Veltkamp, Henk-Willem
Schut, Thomas Victor Paul
De Boer, Meint Jelle
Wiegerink, Remco John
Groenesteijn, Jarno
Lötters, Joost Conrad
Abstract
A method for manufacturing a pair of parallel micro machined channels, using a substrate of a first material and comprising the steps of: - forming two primary perforations in said substrate, spaced apart from each other by a distance that is larger than a width of the channels to be formed; - forming two channel outlines in said substrate, the two channel outlines being spaced apart from each other; - filling the outer circumferential surface of the two channel outlines with a second material, to form said first micro machined channel and said second micro machined channel; - forming two secondary perforations in said substrate, at positions radially outside of the micro machined channels formed in the previous step; - forming two ducts in said substrate, while ensuring that some of the substrate-forming first material remains present between the channels.
The invention relates to a method for estimating positions of a subject's feet and centre of mass relative to each other during gait. The method comprises a step of collecting measurement data from a first inertial measurement unit located at a first foot or first shank of the subject, from a second inertial measurement unit located at a second foot or second shank of the subject, and from a third inertial measurement unit located at a pelvis of the subject. Further, the method includes a step of evaluating relative positions of the first and second foot and the center of mass of the subject over time, using the measurement data of the first, second and third inertial measurement unit. The method may include a step of applying the assumption that a moment around a center of mass of the subject vanishes for determining an estimation of relative foot positions.
The present invention relates to a mold for preparing a hollow 3D cell tissue structure such as an organoid, and uses thereof. Methods for preparing a hollow 3D cell tissue structure such as an organoid, in particular a human heart mimic, are also provided.
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) (Spain)
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES (ICFO) (Spain)
NOVELIC DOO BEOGRAD-NOVI BEOGRAD (NOVELIC) (Serbia)
UNIVERSITAT POLITÈCNICA DE CATALUNYA (UPC) (Spain)
Inventor
Mitjans Prat, Francesc
Padilla García, Laura
Kozyreff, Gregory
Acharyya, Nirmalendu
De Goede, Michiel
Chang, Lantian
Dijkstra, Meindert
Garcia Blanco, Sonia M.
Ramón Azcón, Javier
Obregón Núñez, Raquel
Martínez Fraiz, Elena
Toudert, Johann
Martorell Pena, Jordi
Brankovic, Veselin
Mihajlovic, Veljko
Parausic, Marko
Tasovac, Darko
Abstract
The present invention provides a sensor comprising at least one whispering gallery mode resonator, wherein the resonator comprises a Bragg grating arranged over at least a portion of the perimeter of the resonator and wherein the resonator is selectively functionalized for the attachment of analyte receptors.
A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: - the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5 - 400 μm, a chamber width wc selected from the range of 2hc - 10hc, and a chamber length lc defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); - the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).
The invention provides a sensor (100) for sensing a predetermined particle (10) in a fluid (11), wherein the sensor (100) comprises (i) an electrode (110) and (ii) an recognition element (112), wherein the electrode (110) comprises an electrode face (111) configured accessible to the fluid (11), to the predetermined particle (10) in the fluid (11), and to a redox mediator (12) in the fluid (11); and wherein the recognition element (112) is configured to at least temporarily selectively bind with the predetermined particle (10), thereby limiting access of the redox mediator (12) to the electrode face (111) during the binding of the predetermined particle with the recognition element (112).
The invention pertains to a process for manufacturing silicon or germanium quantum dots which process comprises the steps of reacting a Zintl salt or intermetallie compound of post-transition metals or metalloids of silicon or germanium with a halogen-containing oxidizing agent to form halide-terminated silicon or germanium quantum dots; subjecting the halide-terminated silicon or germanium quantum dots to a reduction step by reaction with a reducing agent, to form hydride-terminated silicon or germanium quantum dots; and subjecting the hydride-terminated silicon or germanium quantum dots to, respectively, a hydrosilylation reaction or hydrogermylation reaction with a passivating agent, to form passivated silicon or germanium quantum dots. The process according to the invention makes it possible to obtain quantum dots with a high quantum yield. The invention also pertains to silicon or germanium quantum dots with a quantum yield of at least 20% at an excitation wavelength of 350 nm, and/or at least 15% at 370 nm.
C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
Aspects of the present disclosure describe systems, methods and structures including an integrated-optics-based externa-cavity laser configured for mode-hop-free wavelength tuning having an increased continuous tuning range with an ultra-narrow linewidth by increasing tuning sensitivity. Ultra-narrow linewidth is provided by extending cavity length with a multi-pass resonator based filter that may advantageously include tunable microring resonators that enable single-mode oscillation while contributing to the optical length of the laser with multiple passes of light through the ring(s) per roundtrip in the laser cavity. Further aspects of the present disclosure describe systems, methods, and structures exhibiting an enhanced "tuning sensitivity" – defined by a continuous wavelength shift per induced cavity phase shift by a phase section. Such tuning sensitivity is increased by approximately a factor of 3 for synchronous tuning of phase section and ring resonators as compared to tuning phase section only.
patents
