A device and methods for a magnetic micro-needle enables the selection of immunomagnetically labelled target cells. By changing the magnetic strength of the needle the speed and selectivity of the cell, selection can be adapted thus differentiating between cells with different amounts of magnetic labelled antigens on the surface of the target cells. The magnetic micro-needle thus makes use of the same cell property as used for their enrichment from the bodily fluid and identification of the target cells by their immunofluorescence profile to allow the use of the same platform avoiding any need to transfer the immunomagnetically enriched sample before selection of the cells by the magnetic micro-needle, making this device ideally suited for subsequent detailed interrogation.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
2.
A DUAL-MODE NONLINEAR RADAR ARRANGED FOR HARMONIC AND INTERMODULATION OPERATION, AS WELL AS A CORRESPONDING METHOD
A dual-mode radar arranged for harmonic and intermodulation operation, said dual-mode radar comprising a transmitter system arranged for detecting an object, said transmitter system comprising a main transmitter arranged for transmitting a first signal towards said object, said first signal having a first frequency, at least one auxiliary transmitter arranged for transmitting a second signal, simultaneously with said first signal, towards said object, said second signal having a second frequency, said second frequency being different, but in a same order of magnitude, to said first frequency, and a receiver system, comprising a receiver arranged for simultaneously receiving a harmonic return signal corresponding to said first signal and receiving an intermodulated return signal corresponding to said first and second signal.
G01S 7/03 - Détails de sous-ensembles HF spécialement adaptés à ceux-ci, p. ex. communs à l'émetteur et au récepteur
G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
G01S 13/32 - Systèmes pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées
G01S 13/58 - Systèmes de détermination de la vitesse ou de la trajectoireSystèmes de détermination du sens d'un mouvement
G01S 13/75 - Systèmes utilisant la reradiation d'ondes radio, p. ex. du type radar secondaireSystèmes analogues utilisant des transpondeurs alimentés par les ondes reçues, p. ex. utilisant des transpondeurs passifs
G01S 7/292 - Récepteurs avec extraction de signaux d'échos recherchés
G01S 13/34 - Systèmes pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées utilisant la transmission d'ondes continues modulées en fréquence, tout en faisant un hétérodynage du signal reçu, ou d’un signal dérivé, avec un signal généré localement, associé au signal transmis simultanément
The invention provides a method for determining a property of a target area of a material, wherein the target area has a size selected from the range of 100 μm2-100 mm2, wherein the method comprises: an exposure stage comprising providing a liquid jet to the target area, wherein the liquid jet has a jet velocity selected from the range of 2-150 m/s; a measurement stage comprising detecting a deformation of the material in the target area and providing a related signal; and an analysis stage comprising determining the property of the target area based on the related signal.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61M 5/30 - Seringues pour injection par projection, sans aiguille, p. ex. utilisables avec des ampoules ou des cartouches échangeables
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
C25B 13/02 - DiaphragmesÉléments d'espacement caractérisés par la configuration ou la forme
C25B 13/05 - DiaphragmesÉléments d'espacement caractérisés par le matériau à base de matériaux inorganiques
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 9/70 - Assemblages comprenant plusieurs cellules
5.
AN ASSEMBLY AND A METHOD FOR DETERMINING A TEMPERATURE DISTRIBUTION OF A FOOT
The invention relates to an assembly and method for determining a temperature distribution of a foot. The assembly comprises : a mat comprising a surface for receiving and conforming to at least part of a plantar surface of the foot, wherein a temperature distribution of the surface of the mat is locally changeable by the plantar surface, and a thermal imaging apparatus comprising a detector responsive to infrared radiation and configured for acquiring a thermal image of at least the surface of the mat. The method uses the thermal imaging apparatus of the assembly to acquire a thermal image of a thermal footprint left on the surface of the mat by at least part of a plantar surface of the foot. The thermal image provides a map or image that substantially corresponds to the temperature distribution of at least part of the plantar surface of the foot.
The invention provides a system (100) for in vitro modelling of biologically induced compression, wherein the system (100) comprises a channel (110), a first matrix material (121) and a second matrix material (122), wherein one or more of the first matrix material (121) and the second matrix material (122) comprises pancreatic stellate cells (126), wherein the channel (110) comprises cells (116), wherein the first matrix material (121) surrounds a first channel part (111) of the channel (110), and wherein the second matrix material (122) surrounds the first matrix material (121) and a second channel part (112) of the channel (110); wherein the first matrix material (121) and the second matrix material (122) both comprise a material independently selected from the group comprising collagen, gelatin and gelatin methacryloyl; wherein the first matrix material (121) comprises thrombin and n1 g/L fibrinogen, wherein n1 is selected from the range of 2 - 10, and wherein the second matrix material (122) comprises n2 g/L fibrinogen, wherein 0≤n2
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
7.
DETERMINING A RELATIONSHIP BETWEEN A PROBE AND MULTIPLE REFERENCES UNDER ENCRYPTION
A method comprises receiving (201) probe information (88) which indicates, for a probe, per feature, an index which represents a value of the feature. The method further comprises selecting (203), per feature, from reference vectors associated with the feature, a reference vector (451-453) corresponding to the index indicated for the feature. The pluralities of reference vectors (423) are stored in a database. Each of the reference vectors comprises feature comparison scores relating to the references and are fully homomorphically encrypted. Feature comparison scores relating to a reference have been obtained from a lookup table based on a value of the corresponding feature for the reference. The method further comprises calculating (205) a vector (455) of evaluations by summing up the selected reference vectors without decrypting them and determining or enabling to determine (207) a relationship between the probe and each of the references based on the vector of evaluations.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
H04L 9/00 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité
A substrate comprises a carrier (10) that promotes a cultivation of biological entities (30), particularly live cells, more particularly live induced pluripotent stem cells (iPSCs). Said carrier comprises an electrostatically charged exposed surface expressing a first polarity. Said surface is covered by an electrostatically charged first sacrificial layer (11) of a second polarity, opposite said first polarity. Said first sacrificial layer (11) is covered by an electrostatically charged second sacrificial layer (12) of said first polarity, wherein said second sacrificial layer comprises moieties to interact with said biologic entities (30). The entities (30) are detached from said substrate (10,11,12) by disintegrating one or more of said sacrificial layers (11,12) by means of an electrically charged agent, particularly by introducing electrically charged molecules or ions.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
The present invention relates to use of glycogen for maintaining viability of non-perfused tissue or sub-optimally perfused tissue, for increasing survival time of a non-perfused or sub-optimally perfused tissue structure, for preventing necrotic core formation in a non-perfused or sub-optimally perfused tissue structure, and/or for increasing production of angiogenic growth factors by non-perfused or sub-optimally perfused tissue. Also foreseen is the use of glycogen in the prevention of tissue implant rejection in a patient, or in the treatment of a tissue pathology in a patient wherein the glycogen may be in combination with replacement tissue and/or scaffold for tissue ingrowth.
Orthosis device (1), comprising a belt (2), comprising a compression layer (4) comprising opposite ends (5) that are moveable towards and away from each other to tighten and untighten the belt; and an actuator (6) comprising a drive (14), wherein the orthosis device is configured to provide temporary support to a lumbar region of a user during a load transfer activity by the user, the belt further comprising a base layer (3); the compression layer being slidably arranged against at least a part of said base layer during tightening and untightening of the belt; and said actuator being configured to selectively switch the orthosis device between an active state and an idle state, wherein, in order to bring the orthosis device into the active state, the actuator is configured to tighten the belt to provide an increased level of support during the load transfer activity; and in order to bring the orthosis device into the idle state, the actuator is configured to untighten the belt to provide an increased level of wearing comfort.
KETEK GmbH Halbleiter- und Reinraumtechnik (Allemagne)
Universiteit Twente (Pays‑Bas)
Inventeur(s)
Bachmann, Michael
Edler, Simon
Jonker, Dirk
Gardeniers, J.G.E.
Abrégé
In an embodiment a reactor includes an electron source having a first gate-insulator-substrate electron-emission structure (GIS-EE) and configured to inject electrons into a fluid and a transportation system for the fluid configured to adjust a velocity of the fluid when passing the electron source, wherein the electron source is configured to provide the electrons to be injected into the fluid in an interior of the electron source and distant from the fluid, wherein the injected electrons are to initiate at least one chemical reaction in the fluid, wherein, when reaching the fluid, at least part of the injected electrons has a kinetic energy of at most 50 eV, wherein the electrons are propagatable only in solid matter from the interior until emission into the fluid, and wherein the GIS-EE includes an electrically conductive substrate, a transfer layer of a material with a band gap of at least 4 eV on the substrate, a gate electrode of a further electrically conductive material directly on the transfer layer, a first electrical connection structure on the substrate, and a second electrical connection structure on the gate electrode.
A method is provided for the analysis of DLA products incorporating aliquots of leukocytes for processing using CellSearch (DLA-CS). The Reduced Enrichment Reagent protocol (RER) is used to process 0.2x109leukocyte aliquots with 10-fold less enrichment reagents than DLA-CS. Using 1.0x109 leukocyte aliquots a 4-fold increase in tumor cells compared to DLA-CS and a 24-fold increase compared to PB-CS was obtained. Using 10-fold less CellSearch capture reagent, we processed standard leukapheresis aliquots with no loss in tumor cell recovery, while attaining a higher purity. The method allows for 26% of the total leukapheresis sample to be processed using CellSearch reagents, enabling a sufficient number of CTC for tumor cell characterization in most metastatic prostate cancer patients. By the use of DNase the normally seen clumping of cells during the magnetic enrichment procedure is prevented, allowing better identification and further processing of the enriched CTC.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
13.
METHOD AND SYSTEM FOR CONTROLLING AN ANGULAR ORIENTATION OF A SPINNING BODY
The invention relates to a method for controlling an angular orientation of a spinning body with respect to an axis of rotation of the spinning body, comprising the steps of: a) providing the spinning body at a first stable angular orientation with respect to its axis of rotation, the spinning body having three principal moments of inertia about three orthogonal principal axes, the three principal moments of inertia defining a tensor of inertia, wherein the three principal moments of inertia each have a first value and wherein the first values of the three principal moments of inertia are identical so that the tensor of inertia is spherical; b) selecting a second angular orientation of the spinning body with respect to its axis of rotation, the second angular orientation being any angular orientation of the spinning body; and c) varying a value of at least one of the principal moments of inertia in accordance with a predetermined schedule, such that: c1. initially the three principal moments of inertia no longer have identical values and the tensor of inertia is non-spherical, thus causing the angular orientation of the spinning body to gradually change from the first angular orientation to the second angular orientation; and c2. eventually the three principal moments of inertia have identical values again and the tensor of inertia is spherical again to stabilize the spinning body in its second angular orientation. The invention further relates to a system for performing this method, and to a spinning body which comprises such a system.
The invention provides a parallel manipulator element (1000), the parallel manipulator element (1000) comprising a joint element (300), a strut (200) and a flexure element (100), wherein: (I) the flexure element (100) comprises (i) a first element end (110) and a second element end (120), (ii) an element length (LFE), (iii) an element width (WFE), (iii) an element thickness (TFE), wherein the element length (LFE) and the element width (WFE) define an element plane (PE), and (iv) a longitudinal element axis (Al), and a width axis (A4); (II) the strut (200) comprises a first strut end (210), a second strut end (220), and a longitudinal strut axis (A3); wherein: (a) the longitudinal element axis (Al) and the strut axis (A3) define a translation plane (PT), and (b) the width axis (A4) is perpendicular to the longitudinal axis (Al) and parallel to the element plane (PE); (c) the joint element (300) is connected to the second strut end (220), wherein the joint element (300) is configured for connecting the strut (200) to a dynamic movable object (2500); (d) the second element end (120) is connected to the first strut end (210), wherein the strut axis (A3) and the element axis (Al) define an angle (a); (e) the first element end (110) is configured for connecting the flexure element (100) to a static object (2010); (f) the flexure element (100) is configured for (i) twisting around the longitudinal element axis (Al), (ii) rotating (bending) around the width axis (A4), and (iii) translating the second element end (120) in a direction parallel to the translation plane (PT), when being connected to the static object (2010) at the first element end (110) and to the dynamic movable object (2500) with the joint element (300) via the second element end (120).
The present application concerns a method for manufacturing an aluminium oxide optical waveguide doped with rare earth ions. The present application further concerns an aluminium oxide optical waveguide doped with rare earth ions that are preferably manufactured by said method. According to the present invention, the method comprises providing a substrate, depositing an aluminium oxide waveguide core layer doped with ions of a rare earth metal onto the substrate, and arranging a cladding layer on the deposited waveguide core, said arranging comprising at least one processing step during which the deposited waveguide core is subjected to a given maximum temperature. The method is characterized in that depositing the waveguide core comprises forming nano-crystallites in the waveguide core. A lowest temperature at which a quenching percentage of the deposited waveguide core significantly increases, exceeds the given maximum temperature, wherein the given maximum temperature is about 400 degrees Celsius or higher.
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM (Pays‑Bas)
UNIVERSITEIT TWENTE (Pays‑Bas)
Inventeur(s)
Van Bochove, Jan Bastiaan
Grijpma, Dirk Wybe
Poot, Andreas Anthonius
Van Dommelen, Lieke Henrica Anna
Van Kuppevelt, Antonius Henricus Minardus Severus Marie
Daamen, Wilhelmina Francisca
Abrégé
Disclosed is a functionalized collagen material comprising insoluble collagen fibrils having attached acrylic side groups, preferably methacrylate groups, and a crosslinked network of said functionalized collagen. Also disclosed is a hybrid polymer co-network made of acryl-functionalized collagen, particularly insoluble collagen fibrils, and an acryl-functionalized hydrophobic biodegradable polymer, preferably poly(trimethylene carbonate). The polymers are dissolved or dispersed in a common solvent, and subjected to reaction so as to enable the acryl groups to form crosslinks within either polymer, and between both of the polymers.
G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
18.
SWITCHABLE OPTICAL LIGHT SOURCE AND LIGHT SWITCHING UNIT
The present application concerns a switchable optical light source comprising a coherent light source and a light switching unit, configured to receive coherent light from the coherent light source. The light switching unit comprises a first optical resonator into which the coherent light is optically coupled, and a second optical resonator optically coupled to the first optical resonator. The first and second optical resonators are both Kerr active and Brillouin active. By changing the coupling factor corresponding to the optical coupling between the first and second optical resonators, and at least one of (A) an optical path length of at least one of the first and second optical resonators and (B) a frequency of the coherent light, the switchable optical light source can be switched between operating in a first operational state, in which the switchable optical light source functions as a Kerr frequency comb generator and a second operational state, in which the switchable optical light source functions as a Brillouin laser.
G02F 1/225 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence dans une structure de guide d'ondes optique
G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence
19.
METHOD FOR DETECTING FLUID PARAMETERS USING A FLOW SENSOR CONFIGURATION
The invention concerns a method for detecting fluid (12) parameters (3) using a sensor configuration (2) of a flow meter (1), comprising: a) flowing training fluids (4) with known fluid parameters through the flow meter, wherein training measurement signals (5) from the sensor configuration are fed to a machine learning model (6); b) training the machine learning model to use real-time measurement signals (7) from the sensor configuration to detect real-time fluid (12) parameters (8); and c) using the trained machine learning model and real-time measurement signals fed to the trained machine learning model, to detect real-time fluid parameters, wherein feeding the real-time measurement signals from the sensor configuration to the machine learning model comprises processing (9) the real-time measurement signals by performing feature extraction or feature learning (10) thereon and feeding the processed real-time measurement signals (19) to the trained machine learning model.
G01F 25/10 - Test ou étalonnage des appareils pour la mesure du volume, du débit volumétrique ou du niveau des liquides, ou des appareils pour compter par volume des débitmètres
G01F 1/84 - Débitmètres massiques du type Coriolis ou gyroscopique
G01N 9/32 - Recherche du poids spécifique ou de la densité des matériauxAnalyse des matériaux en déterminant le poids spécifique ou la densité en utilisant les propriétés d'écoulement des fluides, p. ex. l'écoulement à travers des tubes ou des ouvertures
20.
AN ABERRATION COMPENSATING UNIT AND METHOD, AND A LIGHT OPTICAL DEVICE COMPRISING SUCH A UNIT.
The invention relates to an aberration compensating unit, a light optical device comprising such an aberration compensating unit, and a method for providing an aberration compensation or correction in such a light optical device. The aberration compensating unit comprises a series arrangement of a spatial light modulator and a multi-focus element. The multi-focus element is configured to focus light from the spatial light modulator into an arrangement of multiple foci distributed over a focus plane of the multi-focus element. In the light optical device, the aberration compensating unit is arranged in an optical path of the light optical device between a light source and an objective lens. Both the spatial light modulator and the multi-focus element are configured for providing an at least partial compensation or correction of one or more of the optical components in the light optical device.
G02B 26/06 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la phase de la lumière
B23K 26/064 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples au moyen d'éléments optiques, p. ex. lentilles, miroirs ou prismes
G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,
21.
AMMONIUM POLYPHOSPHATE LOADED PARTICLES AS A FLAME RETARDANT IN POLYMER COMPOSITIONS
The present invention relates to particles comprising a core comprising a water soluble flame retardant, such as ammonium polyphosphate and a shell comprising polyphenols, such as lignosulfonates. These particles may be used as flame retardants, in particular in polymer foams.
C08L 75/08 - Polyuréthanes à partir des polyéthers
C08J 9/12 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent physique de gonflage
The present invention relates to particles comprising a core comprising a water-soluble ammonium polyphosphate and a shell comprising polyphenols, and to the use of these particles as flame retardants, in particular in polyurethane foams.
C08L 75/08 - Polyuréthanes à partir des polyéthers
C08J 9/12 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent physique de gonflage
F25D 3/12 - Dispositifs utilisant d'autres agents froidsDispositifs utilisant des récipients conservant le froid utilisant des gaz solidifiés, p. ex. de la neige carbonique
The present disclosure relates to a magnetic field inductor for navigating and positioning a magnetic manipulation element in a clinical environment. The magnetic field inductor including an electromagnetic coil for generating a magnetic field, the electromagnetic coil comprising at least one conductive element, for instance a copper wire, wound in a plurality of windings around a core extending in axial direction, thereby providing an outer circumferential coil element surface. The magnetic field inductor including a conduit assembly, including at least one fluid conduit for carrying a fluid coolant, the at least one fluid conduit being arranged in a pattern around the outer circumferential coil element surface of the electromagnetic coil and being configured to be in thermally conductive contact with the outer circumferential coil element surface in order to allow conduction of heat between the at least one conductive element and fluid coolant in the at least one fluid conduit.
The invention provides a system (1) to provide life support comprising an ambulatory system (1000) comprising an extracorporeal membrane oxygenation system (200), a mobile gas supply (500), and a mobile frame (100), wherein the extracorporeal membrane oxygenation system (200) comprises (i) a rechargeable power supply (300), (ii) an oxygenator (210), and (iii) a heat exchanger (1400) for controlling a temperature of a blood (2210) flowing through the extracorporeal membrane oxygenation system (200), wherein the system (1) is configured for operating in an ambulatory mode and for operating in a stationary mode; wherein in the ambulatory mode (i) the temperature control fluid inlet (1421) and the temperature control fluid outlet (1422) are closed, (ii) the rechargeable power supply (300) provides the power for (or to) the extracorporeal membrane oxygenation system (200), and (iii) the mobile gas supply (500) is fluidically coupled to the oxygenator (210)); and wherein in the stationary mode (i) a stationary temperature control fluid supply (450) is coupled to the temperature control fluid inlet (1421) and a stationary temperature control fluid discharge (460) is coupled to the temperature control fluid outlet (1422), (ii) a stationary power supply (1300) is coupled to the extracorporeal membrane oxygenation system (200), and (iii) a stationary gas supply (1500) is fluidically coupled to the oxygenator (210).
A61M 5/30 - Seringues pour injection par projection, sans aiguille, p. ex. utilisables avec des ampoules ou des cartouches échangeables
A61B 18/26 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet pour produire une onde de choc, p. ex. lithotritie par laser
27.
THERMAL FLOW SENSOR FOR DETERMINING A FLOW RATE OF A FLUID
The invention relates to a thermal flow sensor (2) for determining a flow rate of a fluid (1), comprising: - a sensor body (11) with a flow section (12), through which fluid flows (3) in a flow direction during use, - a flow sensor configuration (13), comprising multiple flow sensing elements (14), such as two or three, arranged at multiple locations in the flow section for measuring the flow velocity at different locations in the flow section, wherein the multiple flow sensing elements (14) are arranged parallel to each other in a plane parallel to the flow section, and wherein single flow sensing elements (14) of the multiple flow sensing elements (14) can be read out.
The invention relates to a method for determining a flow rate of a fluid (1) independent of the physical properties of the fluid comprising: placing a thermal flow sensor (2) in thermal contact with a fluid flow (3); measuring flow rate; placing a thermal property sensor (4) in a measurement cavity (5) in fluidic contact with the fluid flow, wherein the measurement cavity is fully open to the fluid flow; receiving a portion (6) of the fluid in the measurement cavity of the thermal property sensor, in such a way, that the portion of the fluid is essentially stationary in the measurement cavity; measuring at least one thermal property (K, pep) of the fluid; and compensating the measured flow rate for the at least one measured thermal property.
42 44, an aluminum phyllosilicate material for use in the same, and an adsorbent comprising the aluminum phyllosilicate material. The aluminum phyllosilicate material is characterized by the intercalating moieties and basal spacing, allowing the selectivity in adsorption.
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
The present invention relates to a light source for generating an optical frequency comb. The present invention further relates to a method for manufacturing the optical resonator used in this light source. The present invention additionally relates to microelectromechanical systems, MEMS, optical switch and system comprising the same. The present invention also relates to a sensor and to a method for manufacturing a suspended silicon nitride structure comprised in the sensor. According to the present invention, a single-step LPCVD deposited monolithic stoichiometric Si3N4 layer is used on a mono-crystalline aluminum oxide substrate such as sapphire. The thickness of the Si3N4 layer exceeds 500 nm. This layer can be realized with relatively low residual stress.
C09K 5/06 - Substances qui subissent un changement d'état physique lors de leur utilisation le changement d'état se faisant par passage de l'état liquide à l'état solide, ou vice versa
32.
METHOD FOR MANUFACTURING AN ALUMINIUM OXIDE OPTICAL WAVEGUIDE, AND ALUMINIUM OXIDE OPTICAL WAVEGUIDE
The application concerns a method for manufacturing an optical waveguide. The method comprising providing a substrate, depositing an aluminium oxide waveguide core on the substrate, and arranging a cladding layer on the deposited aluminium oxide waveguide core. The arranging comprising at least one processing step during which the deposited aluminium oxide waveguide core is subjected to a given maximum temperature. The method is characterized in that depositing the aluminium oxide waveguide core comprises forming nano-crystallites in the aluminium oxide waveguide core, and that the temperature the aluminium oxide waveguide core would be required to have for significantly increasing a size of the formed nano¬ crystallites during arranging of the cladding layer exceeds the given maximum temperature, wherein the given maximum temperature is about 800 degrees Celsius or higher.
G02B 6/132 - Circuits optiques intégrés caractérisés par le procédé de fabrication par le dépôt de couches minces
G02B 6/10 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques
C23C 14/00 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement
33.
METHOD FOR MANUFACTURING AN ALUMINIUM NITRIDE OPTICAL WAVEGUIDE, AND ALUMINIUM NITRIDE OPTICAL WAVEGUIDE
characterised in thatcharacterised in that depositing the aluminium nitride waveguide core comprises forming nano-crystallites in the aluminium nitride waveguide core, and in that the temperature the aluminium nitride waveguide core would be required to have for significantly increasing a size of the formed nano-crystallites during arranging of the cladding layer exceeds the given maximum temperature, wherein the given maximum temperature is about 800 degrees Celsius or higher.
G02B 6/10 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques
G02B 6/132 - Circuits optiques intégrés caractérisés par le procédé de fabrication par le dépôt de couches minces
C23C 14/00 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement
13 ABSTRACT The invention relates to a continuum manipulator, including an elongated body defining a virtual axis extending in a longitudinal direction. The elongated body includes at least two magnets, distributed along the virtual axis and arranged such that the magnetic fields of these two magnets 5 are oriented along the virtual axis, at least one flexible segment, each arranged in between two neighboring magnets and having a length defining a distance between two neighboring magnets. Wherein a resilience of the at least one segment and the mutual attractive force active over the distance between the two neighboring magnets are configured such that the elongated body is predisposed to flex under influence of an externally applied first magnetic field comprising a 10 constant component transverse to the magnetic fields of the at least two magnets, and to stretch out in the longitudinal direction in the absence of the first externally applied magnetic field. [Fig. 1.] 15
A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
35.
METHOD AND SYSTEM FOR FORMING MICRO-CAPSULES COMPRISING A CORE SURROUNDED BY A SHELL
A system for forming micro-capsules comprising a core surrounded by a shell comprises a liquid container (1) and jet means (30) for generating and maintaining a liquid jet. The liquid container is connected to supply means (10,15) for supplying a shell liquid to a fill level of said container. The container is bound by a wall (4) having at least one opening (5) below said fill level that is substantially leak-free to said shell liquid. The jet means are connected to a liquid source (20,25) for supplying a liquid flow of a core liquid and comprise a nozzle (30) for ejecting a jet of said core liquid along a jet propagation path (35). The nozzle opens below said fill level (2) within said container at a distance from said opening (5) and is directed to said opening such that said jet propagation path crosses said opening.
The present invention relates to device for detecting at least one target nucleic acid sequence. The device comprises a surface which carries at least one activatable protein which is activated in the presence of the at least one target nucleic acid sequence; one or more reporter constructs which provide a detectable signal upon activation of the activatable protein, wherein the at least one activatable protein and/or the one or more reporter constructs are immobilized, optionally via a linker, to one or more moieties capable of moving along the surface.
The present invention relates to a method for determining CpG methylation of at least one target nucleic acid sequence in a liquid sample, the method comprising a) providing a liquid sample comprising molecules of the at least one target nucleic acid sequence; b) dividing the liquid sample into a plurality of liquid partitions; c) contacting the liquid sample of step a) and/or the liquid partitions of step b) with at least one methylation-sensitive restriction enzyme (MSRE); d) determining proportion of molecules of the at least one target nucleic acid sequence comprising at least one methylated CpG site by detecting proportion of liquid partitions comprising non-restricted molecules of the at least one target nucleic acid sequence and/or detecting proportion of liquid partitions comprising fragments of molecules of the at least one target nucleic acid sequence. The present invention also relates to a kit suitable for performing the method.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
The present invention relates to an optical detector and to an optical detection method. The present invention further relates to an optical sensor and to a method for detecting the quantity and/or presence of a specific molecules in a fluid. The optical detector of the present invention comprises a cascaded optical ring resonator (25A,25B) and is characterized in that the processing unit (5) used for processing the detector signal is configured to obtain transform, T, data by performing a first transform on the detector signal, to select respective T data for each of the closed-loop optical waveguides among the T data, and to perform a second transform being an inverse of the first transform on the selected respective T data for each of the closed-loop optical waveguides, wherein the first transform is configured for transforming data in the time domain to data in the frequency domain.
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
39.
MRI COMPATIBLE ROBOTIC DEVICE FOR ABLATION TREATMENT
MRI compatible robotic device for Ablation Treatment, wherein said robotic device comprises: - a base member for placement on an outer skin surface of a human body; - a needle holding member for holding at least two needles; - a positioning system for moving the needle holding member with respect to the base member in at least two degrees of freedom for positioning the at least two needles at any orientation and at any location within an area of the outer skin surface of the human body that is covered by the robotic device.
A61B 90/11 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre avec des guides pour aiguilles ou instruments, p. ex. des glissières courbes ou des articulations à rotule
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A system comprising a body wearable unit, with one or more cameras, a control system, and an electrical power source and a method for generating wearer data using the system, wherein the method comprises monitoring with one or more cameras a user wearing the wearable unit and providing a related camera signal; generating wearer data based on the related camera signal, wherein the wearer data comprise one or more of (i) wearer posture related data and (ii) wearer movement related data.
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
A43B 3/44 - Chaussures caractérisées par la forme ou l'utilisation avec dispositions électriques ou électroniques avec capteurs, p. ex. pour détecter le contact ou la position
A system for additive manufacturing of a product from an electrically conductive depositable material. The system comprises a support element, a material addition system, and two electrodes. The support element supports the product, wherein the two electrodes comprise electrodes configured at a surface of the support element. The material addition system deposits the material at one or more of (i) the support element and (ii) deposited material, thereby forming the product. Any one of the electrodes is configured for (i) electrically contacting the material being deposited or (ii) electrically contacting the deposited material, during depositing of the material. (i) the material is deposited with a portion of the deposited material and arranged between the electrode and another one of the electrodes to define an electrically conductive path. Alternatively, (ii) a portion of the deposited material is arranged between the electrode and another one of the electrodes to define the electrically conductive path.
A key holder includes a ferrule, a multimode light guide at least partly embedded inside the ferrule, an optical key which has a light scattering material, and a mechanical mount which mounts each of the ferrule, the multimode light guide, and the optical key. The multimode light guide has a front facet and a back facet which are arranged at opposite ends. The back facet of the multimode light guide contacts the optical key. Light can enter into the multimode light guide via the front facet, propagate through the multimode light guide, be scattered by the optical key, and propagate back through the multimode light guide and exit via the front facet. The mechanical mount is detachably connected to a mechanical mount terminator. The front facet of the multimode light guide is oriented in a direction of the mechanical mount terminator.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
G02B 6/38 - Moyens de couplage mécaniques ayant des moyens d'assemblage fibre à fibre
The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
44.
HANDHELD LASER-BASED PERFUSION IMAGING APPARATUS AND METHOD OF USING SAID APPARATUS
Disclosed is a handheld laser-based perfusion imaging apparatus having a light source and an imaging device which are arranged in a fixed orientation to each other in the apparatus. The light source is configured for projecting a beam of coherent light onto a measurement field at a predetermined distance spaced apart from the apparatus. The imaging device is configured for recording speckle intensity maps of the measurement field and/or images of Doppler shifted light of the measurement field. The light source is configured to provide a substantially spherical wavefront or a substantial planar wavefront, at least at the measurement field. Preferably, the apparatus with the light source that provides a substantial planar wavefront, including a gimbal mount. Also disclosed is a method for measuring a perfusion in a tissue using the handheld laser-based perfusion imaging apparatus as described above.
A method and system for concentrating an analyte (A). Liquid droplets (D) of an extractant liquid (Le) are adhered to a wall (10w) of a container, e.g. capillary tube. A sample fluid (Fs) comprising the analyte (A) is provided in the container (10) to contact the liquid droplets (D). The analyte (A) has a higher solubility in the liquid droplets (D) than in the sample fluid (Fs). This causes the analyte (A) to be extracted from the sample fluid (Fs) and concentrated in the liquid droplets (D). After extraction, the liquid droplets (D) are collected, e.g. scraped, from the wall (10w) for obtaining the concentrated analyte (A). A concentrated liquid (La) can be formed by collecting the liquid droplets (D) from the wall (10w). The analyte (A) can be measured in the concentrated liquid (La) using any suitable measurement technique.
A pump configured to pump a magnetic mixture in a flow direction. The pump comprises a channel comprising an ascending portion and a descending portion and a magnetic field generating unit, arranged adjacent to and at least partially enclosing adjoining sections of the ascending portion and the descending portion. The magnetic field generating unit generates a magnetic field varies a magnetic field strength of the magnetic field between a first average field strength, and a second average field strength, lower than the first average field strength, such that: - when the magnetic field has the first average field strength, a first volume of the magnetic mixture present in the ascending portion of the channel is urged to flow in the flow direction, from the ascending portion into the descending portion, and, - when the magnetic field strength is lowered to the second average field strength, the first volume of magnetic mixture present in the enclosed section of the descending portion is allowed, under the influence of gravity, to flow in the flow direction, out of, and thereby at least partially draining the enclosed section of the descending portion.
The invention provides a method for subcooling a cryogenic liquid (1), the method comprising providing a discharge element (2) comprising a first discharge element portion (23) comprising (i) a discharge element inlet opening (21), (ii) a throttle element (25), and (iii) a heat conductive wall (28); providing a cryogenic liquid (1) in an open container (10); immersing the first discharge element portion (23) in the cryogenic liquid (1) in the open container (10); and reducing a pressure in the discharge element (20) at a downstream side (26) of the throttle element (25), thereby inducing a flow of the cryogenic liquid (1) from an upstream side (24) of the throttle element (25) through the throttle element (25), wherein at least part of the cryogenic liquid (1) changes phase at the downstream side (26) of the throttle element (25), thereby providing a heat flow from the cryogenic liquid (1) surrounding the discharge element (20) to the first discharge element portion (23).
KOREA INSTIITUTE OF MEDICAL MICROROBOTICS (République de Corée)
INDUSTRY FOUNDATION OF CHONNAM NATIONAL (République de Corée)
Inventeur(s)
Alaa Eldin Adel Mohamed Mahmoud, Sadek
Mina Maged Michael, Farag
Sarthak, Misra
Islam S. M., Khalil
Park, Jong Oh
Kim, Chang Sei
Abrégé
The invention relates to a spherical electromagnetic actuator. The spherical electromagnetic actuator including a spherical permanent magnet having a center region, a housing comprising a chamber enclosing the spherical magnet and having an inlet for receiving a fluid. The actuator further including three electromagnetic coil assemblies with each coil assembly having at least one coil and a virtual symmetry axis, and wherein the three electromagnetic coil assemblies are arranged such that the three respective symmetry axes intersect at a center region the spherical permanent magnet. The housing is arranged such that in operation the fluid causes the spherical magnet to levitate. And, in operation, the three electromagnetic coil assemblies provide a superpositioned magnetic field manipulating the orientation of the spherical magnet. The invention further relates to a method for controlling the magnetic field of at least one spherical magnetic actuator.
H02K 26/00 - Machines adaptées pour le fonctionnement en moteur-couple, c.-à-d. pour exercer un couple quand elles sont arrêtées
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
H02K 41/03 - Moteurs synchronesMoteurs pas à pasMoteurs à réluctance
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
H02K 11/215 - Dispositifs utilisant un effet magnétique, p. ex. des éléments à effet Hall ou magnéto-résistifs
H02K 11/25 - Dispositifs pour détecter la température ou actionnés par des valeurs de cette variable
H02K 11/27 - Dispositifs pour détecter le courant ou actionnés par des valeurs de cette variable
H02K 11/30 - Association structurelle à des circuits de commande ou à des circuits d’entraînement
The present invention relates to use of a P-containing polymer for measuring 31P-MRI, wherein the P-containing polymer is selected from polyphosphates, polyphosphonates, poly(phosphine oxide)s, polyphosphazenes, polyphosphinates, polyphosphoramidates, polyphosphorodiamidates, polyphosphoamides, polythionophosphates, and polythionophosphonates. The invention furthermore relates to a polyphosphonate copolymer and an aqueous suspension comprising micelles of the polyphosphonate copolymer.
A method for determining a scaled respiratory flow rate and volume during respiration of a patient includes a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure, b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship, c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship, and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation. Step a) is performed during tidal breathing of the patient. A system for performing the aforementioned method.
INSTITUT HOSPITALO-UNIVERSITAIRE DE STRASBOURG (France)
UNIVERSITEIT TWENTE (Pays‑Bas)
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
Inventeur(s)
Stramigioli, Stefano
Cotin, Stéphane
Van As, David
Bessard Duparc, Rémi
Perretta, Silvana
Abrégé
Disclosed is a device for simulating the movement of an endoscope in an environment, including: a tube modelling an endoscope tube; and a tracking module including a housing into which the tube is insertable and movable. The tracking module includes a detector of movements of the tube in the housing and a unit for communicating the detected movements to a controller. The controller is configured to generate, at each instant, an image of a portion of an environment based on the movements of the tube detected by the detector so as to simulate the movement of an endoscope in the environment. The tracking module includes a fastener adapted to fasten the tracking module in a releasable manner onto a support.
A method for monitoring a system for injecting heated air into a patient. The system includes a source of air, a device for heating the air, a cannula for insertion into nostrils of the patient, a first conduit interconnecting the source and the device, and a second conduit interconnecting the device and the cannula. The method includes deriving pressure in the cannula from pressure of the air between the source and the cannula. The method includes measuring a pressure of the air at between the source and the cannula, determining a flow rate of the air in the system, deriving a first function representative of a respiratory flow rate of the patient from the measured pressure and the system air flow rate, deriving a second function representative of a respiratory volume of the patient from the measured pressure and the system air flow rate, and graphically displaying the functions.
The present invention provides a method for separating high-methylated DNA and low- methylated DNA, the method comprising a) providing a liquid sample comprising high- methylated DNA and low-methylated DNA; b) contacting the sample with a surface to which MBD2 proteins are immobilized to allow formation of MBD2-high-methylated DNA complexes on said surface, thereby separating high-methylated DNA and low-methylated DNA. The sample may be a body fluid, preferably a urine sample or a blood plasma sample.
The invention relates to an apparatus and a method for producing a high aspect ratio surface structures on a surface of a substrate. The method comprises the steps of: providing a transfer member, wherein the transfer member extends in a first direction and has a width substantially perpendicular to the first direction, providing a layer of a substance onto the transfer member, wherein the substance and/or the transfer member is/are configured so that there is an adhesion between them, at least partially transferring the substance from the transfer member onto the surface of the substrate by: moving the transfer member and/or the substrate so that the transfer member and the substrate move towards each other until at least the substance contacts the surface of the substrate, and moving the transfer member and/or the substrate so that the transfer member and the substrate move away from each other.
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
A method of printing a cellular solid by direct bubble writing comprises introducing an ink formulation comprising a polymerizable monomer and a gas into a nozzle, which includes a core flow channel radially surrounded by an outer flow channel. The ink formulation is directed into the outer flow channel and the gas is directed into the core flow channel. The ink formulation and the gas are ejected out of the nozzle as a stream of bubbles, where each bubble includes a core comprising the gas and a liquid shell overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell from the liquid shell, and the bubbles are deposited on a substrate moving relative to the nozzle. Thus, a polymeric cellular solid having a predetermined geometry is printed.
B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p. ex. de buses de jet
B29C 64/188 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p. ex. lissage, meulage ou contrôle d’épaisseur
First and second novel membranes for use in a lithographic apparatus are disclosed. The first membrane comprises a core substrate and a metal silicate layer. The metal silicate layer is an outermost layer of the first membrane. The second membrane comprises a core substrate and an yttrium silicate layer. The yttrium silicate layer may be an outermost layer of the membrane or, alternatively, the yttrium silicate layer may be disposed between the core substrate and a layer of yttrium or yttrium oxide. The first and second membranes may be provided within an EUV lithographic apparatus. For example, the membranes may form part of a pellicle. The pellicle may be suitable for use adjacent to a reticle within an EUV lithographic apparatus. Alternatively, the membranes may form part of a dynamic gas lock. Alternatively, the membranes may form part of a spectral filter.
The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: —Providing input signals, —Using said input signals as input variables of a musculoskeletal model, —Determining feedback signals using said musculoskeletal model, —Transmitting said feedback signals to said user of said orthopedic device.
A61F 2/72 - Commandes bioélectriques, p. ex. myoélectriques
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
The invention provides a method for determining a property of a target area (15) of a material (10), wherein the target area (15) has a size selected from the range of 100 μm2− 100 mm2, wherein the method comprises: an exposure stage comprising providing a liquid jet (20) to the target area (15), wherein the liquid jet (20) has a jet velocity selected from the range of 2 − 150 m/s; a measurement stage comprising detecting a deformation (16) of the material in the target area (15) and providing a related signal; and an analysis stage comprising determining the property of the target area (15) based on the related signal.
Ente Ospedaliero Specializzato in Gastroenterologia "Saverio De Bellis" - IRCCS (Italie)
Inventeur(s)
Susarrey Arce, Arturo
Krol, Silke Inge
Berenschot, Johan Willem
Tas, Niels Roelof
Abrégé
The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
60.
Method and apparatus for detecting superparamagnetic material
The invention relates to a method and apparatus for detecting superparamagnetic material. The method comprises applying, by an excitation coil, a magnetic field during a first period to an object to modulate a magnetization of the superparamagnetic material, the magnetic field comprising a first component with a first frequency; positioning a sensing device at a first position from the excitation coil receiving a first signal by a first detection sub-coil in the sensing device and a second signal by a second detection-sub-coil in the sensing device; determining a sensor signal from the first signal and the second signal; determining a detection signal based on the sensor signal; determining a parameter indicating an amount of superparamagnetic material by dividing the detection signal by the first signal, and repeating steps to at at least one different position in order to determine a location where the parameter has a maximal value.
The invention relates to methods for producing a device comprising a plurality of three-dimensional structures. In particular, the invention relates to methods for producing a device comprising a plurality of three-dimensional structures comprising electrodes, in particular three-dimensional electrodes. The invention further relates to uses device comprising a plurality of three-dimensional structures, uses thereof and to methods for culturing cells using such device.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
C30B 28/00 - Production de matériaux polycristallins homogènes de structure déterminée
19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
The present invention relates to a motor system, a stepper motor and a rotor therefor. More in particular, the present invention relates to detecting, in a motor system, an angular position of a rotor of an electric stepper motor. The motor system according to the present invention comprises: a stepper motor, the stepper motor comprising a stator and a rotor, wherein the stator comprises a cavity in which the rotor is arranged, and a plurality of stator coils arranged around a circumference of the cavity, the plurality of stator coils being configured to drive the rotor to rotate in a rotational direction, and wherein the rotor comprises a rotor body having a plurality of rotor poles that are irregularly spaced along a circumference of the rotor body; a driving unit configured to drive each stator coil using a respective driving signal to thereby cause the rotor to rotate; and a position determining unit. The position determining unit is configured to, while the rotor is rotating: measure a current through one or more stator coils among the plurality of stator coils, each current comprising a superposition of at least a driving current as a result of driving a corresponding stator coil and an induced current resulting from a changing magnetic flux through said corresponding stator coil due to the rotating rotor; and determine an angular position of the rotor based on the measured current(s) and a known spacing between the plurality of rotor poles.
H02K 11/21 - Dispositifs pour détecter la vitesse ou la position, ou actionnés par des valeurs de ces variables
H02K 11/27 - Dispositifs pour détecter le courant ou actionnés par des valeurs de cette variable
H02K 37/14 - Moteurs à rotor tournant pas à pas et sans rupteur ou commutateur actionné par le rotor, p. ex. moteurs pas à pas du type à aimant permanent avec des induits fixes et des aimants tournants avec des aimants tournant à l'intérieur des induits
64.
TIME-DOMAIN PHYSICAL UNCLONABLE KEY (TPUK) AUTHENTICATED COMMUNICATION
A method for a PUK authenticated communication includes creating an optical challenge in a time-frequency domain, providing the optical challenge to a tPUK which includes a spatial input channel and a plurality of spatial output channels, and detecting in which of the plurality of spatial output channels a short temporally focused pulse is created. The tPUK provides a complex challenge-response behavior in the time-frequency domain. The optical challenge is created so that the tPUK creates the response having a short temporally focused pulse in only one of the plurality of spatial output channels of the tPUK.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
A fluidic device for processing a fluid or species therein is described. The device comprises a 3D channel including an inlet for receiving a sample fluid and an outlet for outputting the sample fluid. The channel is adapted for guiding flow of the sample fluid in an axial direction from the inlet to the outlet. The channel includes at least two side walls. The device also has a controllable flow inducer having electrodes for inducing, when the sample fluid is flowing through the channel, a motion of the sample fluid in the channel in a plane substantially orthogonal to the axial direction. Along at least one of the side walls at least part of the electrodes are formed by alternatingly at least an electrically conducting portion, an electrically insulating portion and a further electrically conducting portion.
A photovoltaic solar power plant assembly and a method of using said assembly to generate power are disclosed. The assembly includes an array of photovoltaic solar modules arranged in a solar module surface, and an optical structure for redirecting light towards said solar module surface, having a redirected light emitting surface. The optical structure includes: a planar optical waveguide which has a parallel first and second planar waveguide surfaces, wherein the first planar waveguide surface extends parallel to the redirected light emitting surface, wherein the first planar waveguide surface is at least partially covered by a photonic layer which is configured to provide an angular restriction of a light emission from the planar waveguide through the redirected light emitting surface, and a light scattering and/or luminescent material, which material is arranged as particles in the planar optical waveguide and/or in a layer which at least partially covers the second planar waveguide surface.
Stichting voor de Technische Wetenschappen (Pays‑Bas)
UMC Utrecht Holding B.V. (Pays‑Bas)
Universiteit Utrecht Holding B.V. (Pays‑Bas)
Universiteit Twente (Pays‑Bas)
Inventeur(s)
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Guo, Yong
Abrégé
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 71/44 - Polymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
The invention provides a construct (1) comprising a number N of material types (100, 110, . . . ), wherein N is at least 2, wherein at least two of the material types (100, 110, . . . ) comprise granular material (101) comprising particles (10), wherein the granular material (101) at least defines an exterior surface (6) of the construct (1), wherein the construct (1) is self-supporting, and wherein the construct (1) is (i) self-healing or is (ii) configured for being self-healing by changing a liquid (15) content of the construct (1); wherein the different material types (100, 110, . . . ) mutually differ in at least one characteristic (19) selected from the group consisting of a physical characteristic and a chemical characteristic.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
69.
APPARATUS FOR FRICTION STIR APPLICATIONS AND METHOD FOR MANUFACTURING SUCH AN APPARATUS
A friction stir extrusion apparatus for extruding material, comprising a housing, a transport screw and a feeder, the housing comprising a body with a round cavity and extending along a rotational axis and having an input opening for a material feed and an output opening for extruded material; the transport screw having helical ridges along its length is arranged within the cavity and adapted for rotating inside the cavity; the feeder adapted for feeding the material feed to the input opening, wherein a first portion of the cavity is tapered towards the output opening and the transport screw is tapered along the first portion of the cavity, and a gap between a major diameter of the helical ridge of the transport screw and the inner wall of the cavity is constant and non-zero along the first portion.
B23K 20/12 - Soudage non électrique par percussion ou par une autre forme de pression, avec ou sans chauffage, p. ex. revêtement ou placage la chaleur étant produite par frictionSoudage par friction
B29C 48/02 - Petits appareils d’extrusion, p. ex. extrudeuses à main, jouets ou de laboratoire
B29C 48/25 - Éléments constitutifs, détails ou accessoiresOpérations auxiliaires
B29C 48/395 - Moyens pour plastifier ou homogénéiser la matière à mouler ou pour la forcer dans la filière ou la matrice utilisant des vis entourées par un fourreau coopérant, p. ex. des extrudeuses à vis simple
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
G02B 26/00 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
71.
METHOD FOR FORMING A BOND BETWEEN TWO SUBSTRATES OF A DEVICE; DEVICE OBTAINABLE BY THE METHOD; A MICROFLUIDIC DEVICE; AND USE OF THE DEVICE
Provided is a method for forming a bond between two substrates of a device, comprising the steps of: providing a first substrate and a second substrate of a device; providing a first functionalized polyelectrolyte polymer (A) comprising a plurality of electrolyte repeating units, wherein at least one of the electrolyte repeating units is a functionalized repeating unit (G1) comprising a first functional group comprising a first coupling moiety (A1); providing a second functionalized polyelectrolyte polymer (B) comprising a plurality of electrolyte repeating units, wherein at least one of the electrolyte repeating units is a functionalized repeating unit (G2) comprising a second functional group comprising a second coupling moiety (B1); wherein the second coupling moiety (B1) is selected to be complementary for forming a covalent bond to the first coupling moiety (A1) at a temperature below 100ºC; forming a functionalized surface on an exposed surface of the first substrate having the first functionalized polyelectrolyte polymer (A) attached to said first substrate; forming a functionalized surface on an exposed surface of the second substrate having the second functionalized polyelectrolyte polymer (B) attached to said second substrate; contacting at least a part of the functionalized surface of the first substrate onto at least a part of the functionalized surface of the second substrate thereby forming a contact area between the first functionalized polyelectrolyte polymer (A) and the second functionalized polyelectrolyte polymer (B); and forming a covalent bond between the first coupling moiety (A1) and the second coupling moiety (B1) in the contact area between the first substrate and the second substrate for binding the first substrate to the second substrate.
C09J 5/02 - Procédés de collage en généralProcédés de collage non prévus ailleurs, p. ex. relatifs aux amorces comprenant un traitement préalable des surfaces à joindre
72.
ADDITIVE MANUFACTURING OF THERMOPLASTIC COMPOSITES AT AMBIENT CONDITIONS
A method for creating a thermoplastic element by additive manufacturing is presented which includes the steps of: a) providing a resin mixture that at least includes a resin and at least one photo-initiator species in which the resin mixture is liquid at substantially room temperature; b) curing the resin mixture at substantially room temperature using UV-light. The resin mixture for use in the method for manufacturing a thermoplastic element, is substantially liquid at room temperature, and includes at least one photo-initiator species. A device for manufacturing a thermoplastic element is presented that at least includes a preferably moveable nozzle for extruding the resin mixture and a UV-light source arranged at or near an outlet of the nozzle for curing the extruded resin mixture.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
The invention relates to a pressure driven microfluidic chip for delivering a first liquid at a determined flow rate, said chip comprising a first inlet, a container connected to the first inlet, a second inlet connected to the container via a first passage, a second passage connecting the container to an outlet, wherein the first passage has a first resistance to liquid flow, and the second passage has a second resistance to liquid flow. The first resistance may be higher than the second resistance. The invention also relates to a pressure driven method of delivering a first liquid at a determined flow rate comprising using a chip first a first and second passage, wherein the first passage has a first resistance to the flow of the first liquid, and the second passage has a second resistance to flow of the second liquid.
The invention relates to a handheld laser-based perfusion imaging apparatus comprising a light source and an imaging device which are arranged in a fixed orientation to each other in said apparatus. The light source is configured for projecting a beam of coherent light onto a measurement field at a predetermined distance spaced apart from the apparatus. The imaging device is configured for recording speckle intensity maps of the measurement field and/or images of Doppler shifted light of the measurement field. The light source is configured to provide a substantially spherical wavefront or a substantial planar wavefront, at least at the measurement field. Preferably, the apparatus with the light source that provides a substantial planar wavefront, comprises a gimbal mount. Furthermore, the invention relates to a method for measuring a perfusion in a tissue using the handheld laser-based perfusion imaging apparatus as described above.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
75.
PORTABLE SURFACE NANODROPLET-BASED EXTRACTION DEVICE FOR HIGHLY SENSITIVE CHEMICAL ANALYSIS
A method and system for concentrating an analyte (A). Liquid droplets (D) of an extractant liquid (Le) are adhered to a wall (10w) of a container, e.g. capillary tube. A sample fluid (Fs) comprising the analyte (A) is provided in the container (10) to contact the liquid droplets (D). The analyte (A) has a higher solubility in the liquid droplets (D) than in the sample fluid (Fs). This causes the analyte (A) to be extracted from the sample fluid (Fs) and concentrated in the liquid droplets (D). After extraction, the liquid droplets (D) are collected, e.g. scraped, from the wall (10w) for obtaining the concentrated analyte (A). A concentrated liquid (La) can be formed by collecting the liquid droplets (D) from the wall (10w). The analyte (A) can be measured in the concentrated liquid (La) using any suitable measurement technique.
The invention provides a system (1) comprising a body wearable unit (1000), with one or more cameras (200), a control system (300), and an electrical power source (400). The invention further provides a method for generating wearer data using the system (1), wherein the method comprises monitoring with one or more cameras (200) a user wearing the wearable unit (1000) and providing a related camera signal; generating wearer data based on the related camera signal, wherein the wearer data comprise one or more of (i) wearer posture related data and (ii) wearer movement related data.
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
Key holder (1) comprising: a ferrule (2); a multimode light guide (3), in particular a multimode fiber piece (3), at least partly embedded inside the ferrule (2); an optical key (4) comprising a light scattering material; and a mechanical mount (5) mounting the ferrule (2), the multimode light guide (3) and the optical key (4), wherein the multimode light guide (3) comprises a front facet (6) and a back facet (7) provided at opposite ends of the multimode light guide (3) and wherein the back facet (7) of the multimode light guide (3) contacts the optical key (4), wherein the multimode light guide (3) is adapted in such a way that light can enter into the multimode fiber piece (3) via the front facet (6), propagate through the multimode fiber piece (3) in particular via total internal reflection, be scattered by the optical key (4), and propagate back through the multimode light guide (3) and exit via the front facet (6), and wherein the mechanical mount (5) is adapted to be detachably connected to a mechanical mount terminator (50), wherein the front facet (6) of the multimode light guide (3) is oriented in the direction of the mechanical mount terminator (50).
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
G02B 6/38 - Moyens de couplage mécaniques ayant des moyens d'assemblage fibre à fibre
G09C 5/00 - Appareils ou méthodes de chiffrement ou de déchiffrement non prévus dans les autres groupes de la présente sous-classe, p. ex. comportant la dissimulation ou la déformation de données graphiques telles que dessins, messages écrits ou imprimés
A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: —the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5-400 μm, a chamber width we selected from the range of 2hc-10hc, and a chamber length lc defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); —the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).
INSTITUT HOSPITALO-UNIVERSITAIRE DE STRASBOURG (France)
UNIVERSITEIT TWENTE (Pays‑Bas)
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
UNIVERSITÉ DE STRASBOURG (France)
Inventeur(s)
Stramigioli, Stefano
Cotin, Stéphane
Van As, David
Bessard Duparc, Rémi
Perretta, Silvana
Abrégé
The present invention relates to a device (10) for simulating the movement of an endoscope in an environment, comprising. a. a tube modelling an endoscope tube, b. a tracking module (14) comprising a housing (29) into which the tube (22) is insertable and movable, the tracking module (14) comprising means (30) for detecting movements of the tube in the housing and means for communicating the detected movements to a controller (16), the controller (16) being configured to generate, at each instant, an image of a portion of an environment based on the movements of the tube (22) detected by the detecting means (30) so as to simulate the movement of an endoscope in the environment, characterized in that the tracking module (14) comprises fastening means adapted to fasten the tracking module (14) in a releasable manner onto a support.
The invention relates to a method for determining a scaled respiratory flow rate and volume during respiration of a patient, comprising the steps of: a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure; b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship; c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship; and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation wherein step a) is performed during tidal breathing of the patient. The invention further relates to a system for performing this method.
A method for monitoring a system for injecting heated air into a patient is disclosed, wherein the system includes a source of air, a device for heating the air, a cannula for insertion into nostrils of the patient, a first conduit interconnecting the source and the device, and a second conduit interconnecting the device and the cannula. The method comprises deriving a pressure in the cannula from a pressure of the air measured at the first location between the source and the cannula. Additionally or alternatively, the method may comprise the steps of: - continuously or periodically measuring a pressure of the air at a first location between the source and the cannula, - determining a flow rate of the air in the system, - deriving a first function representative of a respiratory flow rate of the patient from the measured pressure and the system air flow rate, - deriving a second function representative of a respiratory volume of the patient from the measured pressure and the system air flow rate, and - displaying the first and second functions in a graphical representation. Also disclosed is an apparatus for performing this method.
The invention provides a system (1000) comprising a microfluidic device (1), wherein the microfluidic device (1) comprises a first side (2), a second side (3), a device plane (6) between the first side (2) and the second side (3), a first channel (100) having a first channel inlet (101) and a first channel outlet (102), a first side chamber (150) extending from the first channel (100) in a direction parallel to the device plane (6), a second channel (200), and a second side chamber (250) extending from the second channel (200) in a direction parallel to the device plane (6); wherein the second channel (200) in combination with the first channel (100) define a double-channel (10) with a double-channel axis (15); and wherein the first side chamber (150) is accessible via a first opening (151) either via the first side (2) or via the second side (3) and wherein the second side chamber (250) is accessible via a second opening (251) either via the first side (2) or via the second side (3).
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
G01N 33/483 - Analyse physique de matériau biologique
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
83.
METHOD FOR CONTROLLING AN ORTHOPEDIC DEVICE AND ORTHOPEDIC DEVICE
The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: - Providing input signals, - Using said input signals as input variables of a musculoskeletal model, - Determining feedback signals using said musculoskeletal model, - Transmitting said feedback signals to said user of said orthopedic device.
ENTE OSPEDALIERO SPECIALIZZATO IN GASTROENTEROLOGIA "SAVERIO DE BELLIS" - IRCCS (Italie)
Inventeur(s)
Susarrey Arce, Arturo
Krol, Silke
Berenschot, Erwin
Tas, Niels
Abrégé
The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
85.
METHOD AND APPARATUS FOR DETECTING SUPERPARAMAGNETIC MATERIAL
The invention relates to a method and apparatus for detecting superpara magnetic material. The method comprises applying, by an excitation coil, a magnetic field during a first period to an object to modulate a magnetization of the superpara magnetic material, the magnetic field comprising a first component with a first frequency; positioning a sensing device at a first position from the excitation coil receiving a first signal by a first detection sub-coil in the sensing device and a second signal by a second detection-sub-coil in the sensing device; determining a sensor signal from the first signal and the second signal; determining a detection signal based on the sensor signal; determining a parameter indicating an amount of superpara magnetic material by dividing the detection signal by the first signal, and repeating steps to at at least one different position in order to determine a location where the parameter has a maximal value.
G01N 27/74 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques des fluides
G01N 27/76 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques des fluides par recherche de la susceptibilité
G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques
G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
A61B 1/313 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'introduction dans des incisions chirurgicales, p. ex. laparoscopes
The present disclosure relates to a conductivity measuring system of a fluid including a solvent and an ionic solute, comprising: —a holder comprising an isolated holder wall defining a fluid channel for holding fluid, wherein the holder is shaped to allow an electrical current induced in the fluid to form a current loop; —an excitation device configured to excite an electric field inside a first part of the fluid channel, the excitation device comprising an electrical signal generator configured to generate an alternating current signal and a conducting slab; —a sensing device arranged at a position remote from the first part of the fluid channel and configured to sense a voltage signal (V) resulting from the changing magnetic field resulting from the current generated inside the fluid by the excitation device.
A fluidic device, in particular a microfluidic chip, for culturing a 3D cell culture comprises a bottom wall defining a bottom side of an open-top chamber arranged for containing a cell culture medium. A fluidic channel extends below the chamber between a channel inlet and a channel outlet for guiding a fluid flow. The bottom wall is provided with a micro-opening through which the chamber and the microfluidic channel are in fluid communication. A side wall extends from the bottom wall circumferentially around the chamber to a top wall opposite the bottom wall. An upper edge of the side wall delimits an open access upper side of the chamber and the top wall is arranged for closing the chamber at the upper side thereof and to be supported by the upper edge of the side wall. A sealing means is provided between opposing surfaces of the upper edge of the side wall and the top wall and arranged for reversible fluid sealing of the side wall and top wall when the chamber is closed at the upper side by the top wall.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A method of printing a cellular solid (120) by direct bubble writing comprises introducing an ink formulation (102) comprising a polymerizable monomer and a gas (104) into a nozzle (106), which includes a core flow channel (108) radially surrounded by an outer flow channel (110). The ink formulation is directed into the outer flow channel (110) and the gas is directed into the core flow channel (108). The ink formulation (102) and the gas (104) are ejected out of the nozzle (106) as a stream of bubbles (112), where each bubble includes a core (114) comprising the gas and a liquid shell (116) overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell (118) from the liquid shell (116), and the bubbles are deposited on a substrate (122) moving relative to the nozzle (106). Thus, a polymeric cellular solid (120) having a predetermined geometry is printed.
B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p. ex. de buses de jet
B29C 64/236 - Moyens d’entraînement pour un mouvement dans une direction dans le plan d’une couche
B29C 64/188 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p. ex. lissage, meulage ou contrôle d’épaisseur
B33Y 40/20 - Posttraitement, p. ex. durcissement, revêtement ou polissage
B22F 12/00 - Appareils ou dispositifs spécialement adaptés à la fabrication additiveMoyens auxiliaires pour la fabrication additiveCombinaisons d’appareils ou de dispositifs pour la fabrication additive avec d’autres appareils ou dispositifs de traitement ou de fabrication
89.
MAGNETIC FIELD GRADIENT APPARATUS AND APPARATUS FOR SEPARATION
The invention relates to a magnet apparatus for generating a magnetic field, the magnet apparatus comprising: at least three coils arranged besides each other along a first axis in a first plane, wherein each coil comprises a conductor comprising a material having superconducting properties at an operating temperature, the coils further comprise two legs and two bent end sections in the first plane, wherein a first and a second leg are arranged parallel to each other along a second axis in the first plane transverse to the first axis, and the two bent sections are arranged opposite to each other; and a controller arranged to control currents through the respective coils to obtain a current distribution in the first plane, wherein a current direction of the current distribution is alternating between opposite directions parallel to the second axis, with a period λ along the first axis. The invention also related to a magnetic density separation apparatus comprising the magnet apparatus.
H01F 27/42 - Circuits spécialement adaptés à la modification ou la compensation des caractéristiques électriques des transformateurs, réactances ou bobines d'arrêt
G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques
90.
Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients
Disclosed are compositions for use in the simultaneous removal of endotoxins from dialysate and uremic solutes from blood during the treatment of patients. The treatment is selected from the group consisting of hemodialysis and hemodiafiltration. The compositions comprise sorbent particles embedded in a membrane comprising a polymer and a hydrophilic additive.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 71/62 - Polycondensats ayant des hétérocycles contenant de l'azote dans la chaîne principale
B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone libreCompositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
A fluidic device for processing a fluid or species therein is described. The device comprises a 3D channel comprising an inlet for receiving a sample fluid and an outlet for outputting the sample fluid. The channel is adapted for guiding flow of the sample fluid in an axial direction from the inlet to the outlet, the channel comprising at least two side walls. The device also comprises a controllable flow inducer comprising electrodes for inducing, when the sample fluid is flowing through the channel, a motion of the sample fluid in the channel in a plane substantially orthogonal to the axial direction. Along at least one of the side walls at least part of the electrodes are formed by alternatingly at least an electrically conducting portion, an electrically insulating portion and a further electrically conducting portion.
The present invention discloses a method and a system for PUK authenticated communication. The method comprises the following steps: creating an optical challenge (1) in a time- frequency domain; providing the optical challenge (1) to a tPUK (2) for creating a response, the tPUK (2) comprising a spatial input channel (3) and a plurality of spatial output channels (4) and the tPUK (2) comprising a complex challenge-response behavior in the time-frequency domain, wherein the challenge (1) is created such that in the response a short temporally focused pulse (7) is created in only one of the spatial output channels (4) of the tPUK (2); and detecting in which output channel (4) the short temporally focused pulse (7) is created.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
G09C 5/00 - Appareils ou méthodes de chiffrement ou de déchiffrement non prévus dans les autres groupes de la présente sous-classe, p. ex. comportant la dissimulation ou la déformation de données graphiques telles que dessins, messages écrits ou imprimés
93.
FOOT PROGRESSION ANGLE DETERMINATION METHOD AND SYSTEM, COMPUTER PROGRAM, AND STORAGE MEDIUM
In a method and system for determining a foot progression angle of a foot, an inertial sensor is connected to the foot. The method comprises a processing system performing the steps of: acquiring, from the sensor, angular velocity data and acceleration data in a sensor coordinate system; identifying, based on said data, a first zero-velocity phase and a subsequent second zero-velocity phase; and during a step of the foot: mapping the angular velocity to a foot coordinate system; integrating the angular velocity to obtain an orientation of the foot direction; mapping the acceleration to the foot coordinate system; subtracting the acceleration of gravity from the acceleration to obtain a corrected acceleration; integrating the corrected acceleration to obtain a linear velocity; integrating the linear velocity to obtain a foot position; and determining the foot progression angle between the orientation of the foot at the first zero-velocity phase or the second zero-velocity phase, and a stepping direction of the foot.
33 as transparent conductive oxide for various applications, by enabling it to be applied on arbitrary substrates. Furthermore, the transparent conductive oxide has favorable optical properties, such as transparency in the IR region.
H01L 31/0392 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur structure cristalline ou par l'orientation particulière des plans cristallins comprenant des films minces déposés sur des substrats métalliques ou isolants
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
A photodetector is provided for sensing radiation in middle and long wave infrared domain. The sensor has a sensor layer of a first material having a first conductivity type and a first permittivity in which the shortest distance of any point in the sensor layer to an adjacent layer having a second conductivity type and a second permittivity lower than the first permittivity is 20 nanometres or less. Conductivity type may be semiconductor n-type or p-type or insulator. If, for example, a silicon sensor layer is sandwiched between two silicon oxide layers, the sensor layer of preferably p-type semiconductor has a maximum thickness of 40 nanometres. If a p-type layer of a first material is sandwiched between a dielectric layer with the second permittivity and an n-type layer of the first material, the maximum thickness is 20 nanometres. Spaced apart, two contacts are provided in contact with the sensor layer.
H01L 31/0232 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails Éléments ou dispositions optiques associés au dispositif
H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
H01L 31/09 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet
96.
PHOTOVOLTAIC SOLAR POWER PLANT ASSEMBLY COMPRISING AN OPTICAL STRUCTURE FOR REDIRECTING LIGHT
The invention relates to a photovoltaic solar power plant assembly and a method of using said assembly to generate power. The assembly comprises an array of photovoltaic solar modules arranged in a solar module surface, and an optical structure for redirecting light towards said solar module surface, comprising a redirected light emitting surface. The optical structure comprises: a planar optical waveguide which comprises a parallel first and second planar waveguide surfaces, wherein said first planar waveguide surface extends parallel to said redirected light emitting surface, wherein said first planar waveguide surface is at least partially covered by a photonic layer which is configured to provide an angular restriction of a light emission from the planar waveguide through said redirected light emitting surface, and a light scattering and/or luminescent material, which material is arranged as particles in the planar optical waveguide and/or in a layer which at least partially covers said second planar waveguide surface.
H01L 31/055 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails adaptés comme dispositifs de conversion photovoltaïque [PV] Éléments optiques directement associés ou intégrés à la cellule PV, p.ex. moyens réflecteurs ou concentrateurs de lumière où la lumière est absorbée et réémise avec une longueur d’onde différente par l’élément optique directement associé ou intégré à la cellule PV, p.ex. en utilisant un matériau luminescent, des concentrateurs fluorescents ou des dispositions de convers
H02S 40/22 - Moyens réflecteurs ou concentrateurs de lumière
A USB communication port comprising a USB male connector (5) and a USB female connector (4) and equipped to transfer information between the USB male connector (5) and the USB female connector (4), wherein the USB male connector (5) is equipped with a first coupling portion and the USB female connector (4) is equipped with a second coupling portion, wherein the first coupling portion and the second coupling portion are arranged to wirelessly transfer data and/or electrical energy between the first coupling portion and the second coupling portion.
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (Pays‑Bas)
Inventeur(s)
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Guo, Yong
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Abrégé
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (Pays‑Bas)
UMC UTRECHT HOLDING B.V. (Pays‑Bas)
UNIVERSITEIT UTRECHT HOLDING B.V. (Pays‑Bas)
UNIVERSITEIT TWENTE (Pays‑Bas)
Inventeur(s)
Stamatialis, Dimitrios
Geremia, Ilaria
Van Nostrum, Cornelus Franciscus
Gerritsen, Karin Gerarda Frederika
Smakman, Robert
Hennink, Wilhelmus Everhardus
Jong, Jacobus Adrianus Wilhelmus
Guo, Yong
Abrégé
The present invention relates to a method for preparing a membrane comprising sorbent particles that bind urea. The invention also relates to the sorbent-comprising membranes per se, and to methods of using the membranes. The membranes are useful for undergoing subsequent reactions with small molecules such as urea, for instance to remove urea from a solution.
The invention provides a construct (1) comprising a number N of material types (100, 110,...), wherein N is at least 2, wherein at least two of the material types (100, 110, …) comprise granular material (101) comprising particles (10), wherein the granular material (101) at least defines an exterior surface (6) of the construct (1), wherein the construct (1) is self-supporting, and wherein the construct (1) is (i) self-healing or is (ii) configured for being self-healing by changing a liquid (15) content of the construct (1); wherein the different material types (100, 110, …) mutually differ in at least one characteristic (19) selected from the group consisting of a physical characteristic and a chemical characteristic.