Abstract

A method for measuring a parameter of a substrate, comprises receiving pump radiation. A metrology target on the substrate is irradiated with the received radiation, thereby generating, through resonances, harmonic generated radiation. Using a metrology sensor, intensities are detected of at least two opposite radiation orders of the harmonic generated radiation diffracted by the metrology target. The parameter of the substrate is determined based on the intensities of the at least two opposite radiation orders and a peak wavelength of the harmonic generated radiation.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G01B 11/02 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness

Abstract

A method and a system for operating a quantum logic gate in an array of trapped ion qubits are described, wherein the method may comprise trapping an array of ion qubits using an electro-magnetic trap; determining an optical signal function to be applied to a first ion qubit and a second ion qubit in the qubit array based on gate operation conditions; generating a polarized optical signal, preferably a linearly polarized pulse, based on the optical signal function; and, applying the polarized optical signal to the first ion qubit and second ion qubit using a first optical tweezer focused onto the first ion qubit and a second optical tweezer focused onto the second ion qubit.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Fusarium oxysporumFusarium oxysporum.Fusarium oxysporum.

IPC Classes  ?

• A01H 1/04 - Processes of selection
• A01H 5/08 - Fruits
• A01H 6/82 - Solanaceae, e.g. pepper, tobacco, potato, tomato or eggplant
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 9/22 - Ribonucleases
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Disclosed is a Fourier-transform spectrometer comprising a beamsplitting arrangement operable to define a first radiation source and a second radiation source from a common radiation source, and at least one detector operable to detect interferogram data as a function of detection position in at least a first detection plane direction of a detection plane, the interferogram data resulting from interference of a first diverging beam emitted from said first radiation source and a second diverging beam emitted from said second radiation source. A processor is operable to: perform a linearization correction to said interferogram data to obtain linearized interferogram data; and Fourier transform the linearized interferogram data to obtain spectral characteristic data relating to the common radiation source.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/453 - Interferometric spectrometry by correlation of the amplitudes
• G01J 3/36 - Investigating two or more bands of a spectrum by separate detectors

Abstract

A metrology system (100, 300, 400) for analyzing fuel at a target location in an EUV radiation source is disclosed. The metrology system comprises at least one radiation-emitting device (105, 110, 115, 305, 310, 315, 405, 410, 415) configured to emit radiation that is directed towards the target location (120, 320, 420). The metrology system also comprises at least one radiation-sensitive device (150, 350, 450) configured to sense radiation from the at least one radiation-emitting device that has passed through fuel at the target location. The at least one radiation-emitting device is configured to emit radiation of at least two different wavelengths. A radiation source (SO) for an EUV lithography apparatus, and a method of analyzing a fuel at a target location in such an EUV radiation source are also disclosed.

IPC Classes  ?

• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

A spectroscopic method and system for simultaneously analyzing molecular structure and size, of a single compound or of a mixture (M) of different molecules (M1, M2). A liquid volume (V) is provided with the mixture (M) having an initial concentration difference (ΔM) between different sub-volumes (Vm,Vs) which are fluidly interconnected and arranged at different locations along a spatial coordinate (X). A time- dependent spectrum (α[t,vj) is measured of light (L) interacting with part of the liquid volume (V), while the concentration difference (ΔM) at least partially equilibrates by diffusion of the different molecules (M1, M2) between the different sub-volumes (Vm,Vs) along the spatial coordinate (X). The time-dependent spectrum (α[t,vj) comprises respective distinct spectral signatures (α1,α2) of the respective different molecules (M1, M2). Each spectral signature (α1,α2) can have a distinct time- dependent evolution (τ1,τ2) in the time-dependent spectrum (α[t,vj) resulting from respective distinct diffusion characteristics (D1,D2) of the different molecules (M1, M2).

IPC Classes  ?

• G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
• G01N 21/05 - Flow-through cuvettes

Abstract

A method for determining a vertical position of a structure on a substrate with respect to a nominal vertical position is disclosed. The method comprises obtaining complex field data relating to scattered radiation from said structure, for a plurality of different wavelengths, determining variation in a phase parameter with wavelength from said complex field data; and determining said vertical position with respect to a nominal vertical position from the determined variation in phase with wavelength.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G01N 21/21 - Polarisation-affecting properties
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

Disclosed is an illumination arrangement for providing at least one radiation beam for use as an illumination beam and/or reference beam in a metrology device. The illumination arrangement comprises at least one radiation beam modifier module operable to receive source illumination and output a modified radiation beam comprising a first beam component and a second beam component. Each radiation beam modifier module comprises at least one path length varying arrangement for controllably varying the optical path length of at least one of said first beam component and said second beam component, such that said first beam component and second beam component of said modified radiation beam comprise a respective different optical path length.

IPC Classes  ?

• G03F 9/00 - Registration or positioning of originals, masks, frames, photographic sheets or textured or patterned surfaces, e.g. automatically
• G02B 5/18 - Diffracting gratings
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G03H 1/04 - Processes or apparatus for producing holograms
• G03F 7/20 - ExposureApparatus therefor
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G02B 21/10 - Condensers affording dark-field illumination
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 26/06 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
• G02B 27/42 - Diffraction optics

Abstract

In accordance with the present invention there is provided a nanoparticle, comprising—a core, —an outer layer, and —a buffer layer located between said core and said outer layer, wherein the buffer layer prevents energy transfer between the core and the outer layer. In another aspect of the invention there is provided a nanoparticle as described herein for use in therapy, a nanoparticle according as described herein for use in treatment of a tumor, and a nanoparticle as used herein for use in in vivo imaging According to another aspect of the invention there is provided a method for the production of a nanoparticle as described herein, comprising the steps of—heating of a solution comprising core precursors, followed by—injection of a dispersion comprising buffer layer precursors, followed by—injection of a dispersion comprising outer layer precursors. Another aspect of the invention is a method for in vivo imaging or treatment or both of a human or animal, comprising the steps of: —administering nanoparticles as described herein to a patient, —irradiating at least part of the patient's body with one or more types of radiation. According to yet another aspect of the invention there is provided the use of a nanoparticle as described herein for therapy, in vivo imaging, or both.

IPC Classes  ?

• C01F 17/36 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6 halogen being the only anion, e.g. NaYF4
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The present invention relates to a method for vegetable sidestream valorisation. The method comprises (a) mixing vegetables with a composition comprising Lactobacilli reuteri bacteria; and (b) fermenting the mixture, whereby a vegetable paste is obtained. Fermentation is for 24-44 hours only and there is no need to add water, heat or nutrients.

IPC Classes  ?

• A23L 19/20 - Products from fruits or vegetablesPreparation or treatment thereof by pickling, e.g. sauerkraut or pickles
• A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics

Abstract

Methods and systems are disclosed for determining a power budget for processor cores of a multi-core processor. The method comprises determining or receiving a threshold temperature for each processor core of the plurality of processor cores, and determining or receiving a current temperature for each processor core of the plurality of processor cores. The method further comprises analytically computing, for one or more processor cores of the plurality of processor cores, one or more respective amounts of power that result in the one or more processor cores attaining their respective threshold temperature at the end of a current epoch, based on the current temperatures and on a thermal model of the processor. The thermal model may comprise a mathematical representation of heat generation and heat flow in the processor. The method further comprises determining a power budget for the one or more processor cores based on the computed one or more respective amounts of power. In an embodiment, the method may further comprise determining or receiving the thermal model.

IPC Classes  ?

• G06F 1/20 - Cooling means
• G06F 1/3206 - Monitoring of events, devices or parameters that trigger a change in power modality
• G06F 1/324 - Power saving characterised by the action undertaken by lowering clock frequency
• G06F 1/3296 - Power saving characterised by the action undertaken by lowering the supply or operating voltage

Abstract

Disclosed is a method for measuring a target located on a substrate beneath at least one layer. The method comprises exciting said at least one layer with pump radiation comprising at least one pump wavelength, so as to generate an acoustic wave within said at least one layer which reflects of said target thereby generating an acoustic replica of said target at a surface of said substrate and illuminating said acoustic replica with probe radiation comprising at least one probe wavelength and capturing the resultant scattered probe radiation, scattered from the acoustic replica. One or both of said exciting step and said illuminating step comprises generating Surface Plasmon Polaritons (SPPs) on residual topography of said at least one layer resultant from said target.

IPC Classes  ?

• G03F 9/00 - Registration or positioning of originals, masks, frames, photographic sheets or textured or patterned surfaces, e.g. automatically

Abstract

BacillusBacillusBacillus host cell of the invention under conditions conducive for the production of the polypeptide or compound of interest.

IPC Classes  ?

• C07K 14/32 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Bacillus (G)
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
• C12P 7/02 - Preparation of oxygen-containing organic compounds containing a hydroxy group
• C12P 13/02 - Amides, e.g. chloramphenicol
• C12P 17/04 - Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin
• C12P 17/06 - Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
• C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
• C12P 23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
• C12P 25/00 - Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin

Abstract

The present invention relates to variants of a monomeric Scarlet Red Fluorescent protein (mScarlet RFP) having enhanced intrinsic brightness and maturation. Said variants comprise at least amino acid substitutions V196I and/or G220A, and optionally amino acid substitution T74I, when compared to the amino acid sequence of synthetically designed mScarlet RFP. The V196I and/or G220A variants of the present invention may comprise one or more further amino acid substitutions. Preferred additional amino substitutions are E219V or the combination of T107S and G156V. The combination of E219V, T107S and G156V in addition to V196I and/or G220A, and optionally T74I, was found to have a beneficial effect on the intrinsic brightness and maturation of the variants of the invention. In particular, the addition of Y84W, Y194F in addition to E219V, T107S, G156V, V196I and/or G220A with optionally K48R, K183R or T74I, N99I, A105T, T128G, K140R was of even larger benefit for the intrinsic brightness and maturation of the variants of the invention.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

A resist composition for use in the fabrication of integrated circuits, the use of a resist composition, and a lithographic method utilising a resist composition, wherein the resist composition comprises an alkyltin-oxo cage having a counterion selected from tetrakis(pentafluorophenyl) borate, tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, tetrakis[3,5-bis(tert-butyl)phenyl]borate, and tetrakis[(3,5-bis(l,l,l,3,3,3-hexafluoro-2-methoxypropan-2-yl)phenyl)phenyl]borate. A lithographic method comprising the steps of: a) providing a resist composition comprising an alkyltin-oxo cage having a counterion selected from the above borate groups; b) exposing the resist composition to a patterned radiation beam or an electron beam to form a pattern in the resist composition; and c) developing the resist to form a circuit pattern.

IPC Classes  ?

• G03F 7/004 - Photosensitive materials

Abstract

Disclosed is a metrology apparatus and method for measurement of a diffractive structure on a substrate. The metrology apparatus comprises a radiation source operable to provide first radiation for excitation of the diffractive structure such that high harmonic second radiation is generated from said diffractive structure and/or substrate; and a detection arrangement operable to detect said second radiation, at least a portion of which having been diffracted by said diffractive structure.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 21/956 - Inspecting patterns on the surface of objects
• G01N 23/22 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material

Abstract

Disclosed is a metrology apparatus for measurement of a target formed on a substrate by a lithographic process and associated method. The metrology apparatus comprises a radiation source operable to provide first radiation; a configured solid high harmonic generation medium being configured to receive and be excited by said first radiation to generate high harmonic second radiation from an output surface of the configured solid high harmonic generation medium; and a detection arrangement operable to detect said second radiation, at least a portion of which having been scattered by said target. The configured solid high harmonic generation medium is configured to shape the beam of said second radiation and/or separate said first and second radiation.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G02F 1/35 - Non-linear optics
• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The invention provides a stereo lithographic 3D printing assembly comprising a digital projection system for projecting a first pattern having a first resolution at a projection location, and a photo mask system for projecting a second pattern having a second resolution at said projection location. This provides a fast 3D printing assembly allowing high resolution details.

IPC Classes  ?

• B29C 64/286 - Optical filters, e.g. masks
• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

Abstract

Disclosed is a wavefront sensor for measuring a wavefront of a radiation. The wavefront sensor comprises a mask comprising a pattern located in path of the radiation to interact with the radiation. The radiation impinging on the mask forms a radiation detection pattern on a radiation detector subsequent to the mask, and the pattern of the mask is designed at least partly based on a requirement of the radiation detection pattern.

IPC Classes  ?

• G01J 1/04 - Optical or mechanical part
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength
• G03F 7/20 - ExposureApparatus therefor

Abstract

In accordance with the present invention there is provided a nanoparticle, comprising - a core, - an outer layer, and - a buffer layer located between said core and said outer layer, wherein the buffer layer prevents energy transfer between the core and the outer layer. In another aspect of the invention there is provided a nanoparticle as described herein for use in therapy, a nanoparticle according as described herein for use in treatment of a tumor, and a nanoparticle as used herein for use in in vivo imaging. According to another aspect of the invention there is provided a method for the production of a nanoparticle as described herein, comprising the steps of - heating of a solution comprising core precursors, followed by - injection of a dispersion comprising buffer layer precursors, followed by - injection of a dispersion comprising outer layer precursors. Another aspect of the invention is a method for in vivo imaging or treatment or both of a human or animal, comprising the steps of: - administering nanoparticles as described herein to a patient, - irradiating at least part of the patient's body with one or more types of radiation. According to yet another aspect of the invention there is provided the use of a nanoparticle as described herein for therapy, in vivo imaging, or both.

IPC Classes  ?

• C01F 17/30 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

An EUV radiation source comprising a fuel emitter configured to produce fuel droplets; a laser system configured to illuminate a fuel droplet at a plasma formation region, the laser system comprising: a first laser configured to produce radiation of a first wavelength in a first radiation beam, a second laser configured to produce radiation of a second wavelength in a second radiation beam, and a first parametric amplifier arranged to receive the radiation of the first wavelength and radiation of the second wavelength and generate an amplified radiation beam; and a beam delivery system for delivering the amplified radiation beam to the plasma formation region.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma
• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves

Abstract

In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a PDE2 inhibitor, a PDE11 inhibitor or a combination thereof, optionally together with a GUCY2C agonist.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Methods and apparatus for forming a patterned layer of material are disclosed. In one arrangement, a deposition-process material is provided in gaseous form. A layer of the deposition-process material is formed on the substrate by causing condensation or deposition of the gaseous deposition-process material. A selected portion of the layer of deposition-process material is irradiated to modify the deposition-process material in the selected portion.

IPC Classes  ?

• C23C 16/04 - Coating on selected surface areas, e.g. using masks
• C23C 16/26 - Deposition of carbon only
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• C23C 16/46 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for heating the substrate
• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation
• C23C 16/56 - After-treatment
• C23C 14/04 - Coating on selected surface areas, e.g. using masks
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• G03F 7/004 - Photosensitive materials
• G03F 7/16 - Coating processesApparatus therefor
• G03F 7/36 - Imagewise removal not covered by groups , e.g. using gas streams, using plasma

Abstract

A dark field digital holographic microscope is disclosed which is configured to determine a characteristic of interest of a structure. The dark field digital holographic microscope comprises an illumination device configured to provide at least: a first beam pair comprising a first illumination beam of radiation (1010) and a first reference beam of radiation (1030) and a second beam pair comprising a second illumination beam of radiation (1020) and a second reference beam of radiation (1040); and one or more optical elements (1070) operable to capture a first scattered radiation and to capture a second scattered radiation scattered by the structure resultant from the first and second illumination beams respectively. The beams of the first beam pair are mutually coherent and the beams of the second beam pair are mutually coherent. The illumination device is configured to impose incoherence (ADI) between the first beam pair and second beam pair.

IPC Classes  ?

• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/26 - Processes or apparatus specially adapted to produce multiple holograms or to obtain images from them, e.g. multicolour technique
• G03F 7/20 - ExposureApparatus therefor

Abstract

The present invention relates to a liquid composition comprising living green microalgae for improving plant growth. The liquid composition is prepared by growing green microalgae at a pH of 10-12 in the presence of hydrogen carbonate as the inorganic carbon source. The liquid composition may be stored at 4 to 25 degrees C. until use. The liquid composition may be used to improve fertilizers.

IPC Classes  ?

• A01G 33/00 - Cultivation of seaweed
• C05G 5/23 - Solutions
• C05F 11/00 - Other organic fertilisers
• C05G 5/27 - Dispersions, e.g. suspensions or emulsions
• C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity

Abstract

Disclosed is a method for a metrology measurement on an area of a substrate comprising at least a portion of a target structure. The method comprises receiving a radiation information representing a portion of radiation scattered by the are, and using a filter in a Fourier domain for removing or suppressing at least a portion of the received radiation information that does not relate to radiation that has been scattered by the target structure for obtaining a filtered radiation information for the metrology measurement, wherein characteristics of the filter are based on target information about the target structure.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G01N 21/956 - Inspecting patterns on the surface of objects

Abstract

Disclosed is a method of determining a complex-valued field relating to a structure, comprising: obtaining image data relating to a series of images of the structure, for which at least one measurement parameter is varied over the series and obtaining a trained network operable to map a series of images to a corresponding complex-valued field. The method comprises inputting the image data into said trained network and non-iteratively determining the complex-valued field relating to the structure as the output of the trained network. A method of training the trained network is also disclosed.

IPC Classes  ?

• G03F 1/84 - Inspecting
• G01N 21/956 - Inspecting patterns on the surface of objects
• G03F 7/20 - ExposureApparatus therefor
• G06T 7/00 - Image analysis
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

The invention provides a stereo lithographic 3D printing assembly comprising a digital projection system for projecting a digitally defined first pattern having a first resolution at a projection location, and a photo mask system for projecting a second pattern having a second resolution and said second pattern and said first pattern aligned with one another at said projection location, said photo mask system providing at least one photo mask between said digital projection system and said projection location. This provides a fast 3D printing assembly allowing high resolution details.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B29C 64/286 - Optical filters, e.g. masks
• G03F 7/20 - ExposureApparatus therefor

Abstract

The invention provides a stereo lithographic 3D printing assembly comprising a digital projection system for projecting a digitally defined first pattern having a first resolution at a projection location, and a photo mask system for projecting a second pattern having a second resolution and said second pattern and said first pattern aligned with one another at said projection location, said photo mask system providing at least one photo mask between said digital projection system and said projection location. This provides a fast 3D printing assembly allowing high resolution details.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G03F 7/20 - ExposureApparatus therefor
• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B29C 64/286 - Optical filters, e.g. masks
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

Abstract

The invention pertains to a process for preparing phosphoric acid from a solid phosphorus-containing material, comprising the steps of: - reacting a solid phosphorus-containing material with strong acid in an amount of 1.0-15 mole acid, calculated as protons, per mole of phosphorus (calculated as P) in the solid phosphorus-containing material in a monophasic reaction medium comprising an organic solvent, to form a solution of phosphoric acid in organic solvent and remaining solid material, - separating the solution of phosphoric acid in organic solvent from the remaining solid material. It has been found that phosphoric acid can be recovered from a solid phosphorus-containing material in high purity and efficiency via a solid-state rearrangement/elution process. The process according to the invention does not require the use of the large amounts of water required by the conventional dissolution/extraction processes known in the art. The solution of phosphoric acid in organic solvent can be used as a starting material for further processes.

IPC Classes  ?

• C01B 25/222 - Preparation by reacting phosphate containing material with an acid, e.g. wet process with sulfuric acid, a mixture of acids mainly consisting of sulfuric acid or a mixture of compounds forming it in situ, e.g. a mixture of sulfur dioxide, water and oxygen
• C01B 25/28 - Ammonium phosphates
• C01B 25/46 - Preparation involving solvent-solvent extraction
• C07D 251/56 - Preparation of melamine

Abstract

Geobacillus stearothermophilus Geobacillus stearothermophilus wherein the variants comprise one or more amino acid substitutions compared to the amino acid sequence of the parent LysEDH. These amine dehydrogenase variants are suitable biocatalysts for reductive amination of carbonyl containing compounds of which the acyl group is attached to a group that cannot readily be replaced by another group.These amine dehydrogenase variants are also suitable biocatalysts for the oxidative deamination of racemic chiral amines.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Abstract

The invention pertains to a process for manufacturing silicon or germanium quantum dots which process comprises the steps of reacting a Zintl salt or intermetallie compound of post-transition metals or metalloids of silicon or germanium with a halogen-containing oxidizing agent to form halide-terminated silicon or germanium quantum dots; subjecting the halide-terminated silicon or germanium quantum dots to a reduction step by reaction with a reducing agent, to form hydride-terminated silicon or germanium quantum dots; and subjecting the hydride-terminated silicon or germanium quantum dots to, respectively, a hydrosilylation reaction or hydrogermylation reaction with a passivating agent, to form passivated silicon or germanium quantum dots. The process according to the invention makes it possible to obtain quantum dots with a high quantum yield. The invention also pertains to silicon or germanium quantum dots with a quantum yield of at least 20% at an excitation wavelength of 350 nm, and/or at least 15% at 370 nm.

IPC Classes  ?

• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C09K 11/59 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing silicon
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor

Abstract

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

An EUV radiation source of a laser-produced-plasma type, comprising: a fuel emitter configured to produce fuel droplets; and a laser system configured to illuminate a fuel droplet with radiation for converting the fuel droplet into a plasma at a plasma formation region; wherein the laser system comprises: a laser configured to produce radiation of a first wavelength; and a nonlinear medium configured to receive radiation of the first wavelength, produce radiation of a second wavelength using a nonlinear optical process at a radiation conversion region, and deliver radiation of the second wavelength to the plasma formation region; wherein the second wavelength is longer than the first wavelength.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a PDE2 inhibitor, a PDE11 inhibitor or a combination thereof, optionally together with a GUCY2C agonist.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 25/16 - Anti-Parkinson drugs
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/10 - Peptides having 12 to 20 amino acids

Abstract

Disclosed is a method for obtaining a computationally determined interference electric field describing scattering of radiation by a pair of structures comprising a first structure and a second structure on a substrate. The method comprises determining a first electric field relating to first radiation scattered by the first structure; determining a second electric field relating to second radiation scattered by the second structure; and computationally determining the interference of the first electric field and second electric field, to obtain a computationally determined interference electric field.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor

Abstract

The invention pertains to a process for manufacturing aromatic nitriles, wherein a starting material selected from the group of aromatic primary alcohols and aromatic aldehydes is contacted under reaction conditions in a reaction vessel with an inorganic amine compound and molecular oxygen in the presence of a Cu-dependent alcohol oxidase. The process of the invention makes it possible to prepare aromatic nitriles from easily available starting materials, namely aromatic primary alcohols or aldehydes, in high efficiency, without having to rely on cyanidesor azides, or stringent reaction conditions.

IPC Classes  ?

• C12P 13/00 - Preparation of nitrogen-containing organic compounds
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)

Abstract

Device (1) for multi-dimensional liquid analysis, such as chromatography. The device comprises a first analysis channel (3) and one or more second analysis channels (5). The first analysis channel comprises a channel wall (21) with outlets (11) connecting the first analysis channel to one of the plurality of second analysis channels, and a valve (7) for opening or closing at least one of the one or more outlets (11)·

IPC Classes  ?

• G01N 30/46 - Flow patterns using more than one column
• G01N 30/20 - Injection using a sampling valve
• G01N 30/60 - Construction of the column
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a GUCY2C agonist. The invention also relates to test systems and cells that are suited to identify new candidate compounds for the treatment of Parkinson's disease.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 25/16 - Anti-Parkinson drugs
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• C12N 9/88 - Lyases (4.)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention provides an assembly comprising: a recording assembly for recording a time-based brain-related signal; a stimulus generator for providing a stimulus, and a computer assembly, functionally coupled to said recording assembly and to said stimulus generator, said computer assembly comprising: a memory for storing at least a data segment of said time-based brain-related signal during recording of said time-based brain-related signal, and a computer program which, when running on said computer assembly, functionally real-time performs: retrieving a most-recent data segment of said stored data segment of said time-based brain-related signal; fitting at least one curve to said retrieved most-recent data segment; predicting a future continuation of said most-recent data segment using said at least one curve fitted to said most-recent data segment; detecting a predefined pattern in said predicted future continuation for predicting occurrence of said predefined pattern, and defining a predicted event time of said predefined pattern, said predicted event time being in the future with respect to said most-recent data segment, and actuating said stimulus generator for providing a stimulus within a predefined event time window of said predicted event time.

IPC Classes  ?

• A61B 5/048 - Detecting the frequency distribution of signals
• A61B 5/0484 - Electroencephalography using evoked response
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a liquid composition comprising living green microalgae for improving plant growth. The liquid composition is prepared by growing green microalgae at a pH of 10-12 in the presence of hydrogen carbonate as the inorganic carbon source. The liquid composition may be stored at 4 to 25 degrees C until use. The liquid composition may be used to improve fertilizers.

IPC Classes  ?

• A01G 33/00 - Cultivation of seaweed
• C05F 11/00 - Other organic fertilisers
• C05G 3/00 - Mixtures of one or more fertilisers with additives not having a specifically fertilising activity

Abstract

Method for manufacturing fluoro(hydro)carbon-substituted silicon or germanium quantum dots which comprises the steps of: - reacting a Zintl salt or intermetallic compound of post- transition metals or metalloids of silicon or germanium with a halogen-containing oxidizing agent to form halide-terminated silicon or germanium quantum dots, - reacting the halide-terminated silicon or germanium quantum dots with a fluoro(hydro)carbon agent selected from the group of metal-fluoro (hydro)carbon compounds of the formula MRq, wherein M is a metal selected from Group 1, 2, 4, 11, 12, 13, or 14 of the periodic table of elements, q is an integer which corresponds to the valence of the metal, and R is CFnHm- fluoro/hydro-carbon, wherein n is 1 or 2, m is 0 or 1, and the total of n and m is 2, wherein each R may be the same or different, metal-fluoro (hydro)carbon halide compounds of the formula NQaRp wherein N is a metal selected from Group 1, 2, 4, 11, 12, 13, or 14 of the periodic table of elements, Q is a halogen selected from F, Cl, Br, or I, wherein each Q may be the same or different, a and p are integers in the range of 1- 3, and the total of a and p corresponds to the valence of the metal, and R is as defined above, and metal-fluoro (hydro)carbon compounds of the formula CuR2Li, wherein R is as defined above, to form fluoro(hydro)carbon-substituted silicon or germanium quantum dots. The method makes it possible to obtain quantum dots with a tailored emission spectrum with high quality in a stable process. The particles obtained by this process are also claimed.

IPC Classes  ?

• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C09K 11/59 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing silicon
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor

Abstract

Methods and apparatus are disclosed for determining a characteristic of a structure. In one arrangement, the structure is illuminated with first illumination radiation to generate first scattered radiation. A first interference pattern is formed by interference between a portion of the first scattered radiation reaching a sensor and first reference radiation. The structure is also illuminated with second illumination radiation from a different direction. A second interference pattern is formed using second reference radiation. The first and second interference patterns are used to determine the characteristic of the structure. Azimuthal angles of the first and second reference radiations onto the sensor are different.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor

Abstract

Disclosed is a method and associated apparatus for measuring a characteristic of interest relating to a structure on a substrate. The method comprises calculating a value for the characteristic of interest directly from the effect of the characteristic of interest on at least the phase of illuminating radiation when scattered by the structure, subsequent to illuminating said structure with said illuminating radiation.

IPC Classes  ?

• G02B 27/42 - Diffraction optics
• G03F 7/20 - ExposureApparatus therefor
• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto

Abstract

A radiation source (SO) of a laser-produced plasma type is described. The radiation source (SO) comprises a droplet generator (3a) configured to provide a fuel droplet (60). The radiation source (SO) comprises a laser system (1) configured to provide a pre-pulse and a main-pulse. The pre-pulse is operative to condition the fuel droplet (60) for receipt of main pulse. The main pulse is operative to convert the conditioned fuel droplet (60) into plasma. The radiation source (SO) comprises a sensing system (16) configured for sensing a characteristic of an oscillation of a spatial mass distribution of the fuel droplet (60). The radiation source (SO) comprises a control system (44) operative to adjust a polarization of the pre-pulse under control of the sensed characteristic. The polarization of the pre- pulse may affect the spatial mass distribution of the conditioned fuel droplet (60).

IPC Classes  ?

• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

Methods and apparatus for forming a patterned layer of carbon are disclosed. In one arrangement, a selected portion of a surface of a solid structure is irradiated with extreme ultraviolet radiation in the presence of a carbon-containing precursor. The radiation interacts with the solid structure in the selected portion to cause formation of a layer of carbon in the selected portion from the carbon-containing precursor. The layer of carbon is formed in a pattern defined by the selected portion.

IPC Classes  ?

• C23C 16/04 - Coating on selected surface areas, e.g. using masks
• C23C 16/26 - Deposition of carbon only
• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation
• C23C 16/56 - After-treatment

Abstract

Multi-chromatic photoluminescent, oxide-capped semiconductor nanocrystals and methods for forming such semiconductor nanocrystals. The method includes exposing one or more oxide-capped semiconductors, preferably type IV semiconductor nanocrystals, to electron beam radiation, wherein the radiation has an energy between 1 and 30 keV, the radiation introducing color centers in the oxide that exhibit photoluminescence in at least the green band of the visible spectrum.

IPC Classes  ?

• C09K 11/59 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing silicon
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Described is a metrology system for determining a characteristic of interest relating to at least one structure on a substrate, and associated method. The metrology system comprises a processor being configured to computationally determine phase and amplitude information from a detected characteristic of scattered radiation having been reflected or scattered by the at least one structure as a result of illumination of said at least one structure with illumination radiation in a measurement acquisition, and use the determined phase and amplitude to determine the characteristic of interest.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G03F 7/20 - ExposureApparatus therefor

Goods & Services

Computer software (recorded programmes) in the field of scientific, human and industrial analysis and research; Downloadable electronic publications in the field of scientific, human and industrial analysis and research; Scientific, nautical, surveying, photographic, cinematographic, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Recording substrates [magnetic]; Phonograph records; CD discs; DVDs/ high density optical discs; USB flash drives; Calculators; Data processing equipment; Computers; Decorative magnets; Luminous signs. Printed matter, printed documents and publications relating to the field of education, teaching, training and instruction, books, newspapers, handbooks (manuals), periodicals, magazines, prospectuses, printed forms; Stationery instructional and teaching material (excluding apparatus), Tickets, Seals [stamps], Forms, printed, Posters, albums, Yearbooks and calendars, Geographical maps, Signboards of paper or cardboard, Envelopes [stationery], Paper sheets [stationery]; Pencils, fountain pens, Nibs, Pen rests, Pencil lead holders, Lithographs, photographs, Blueprints, Paper weights and post cards, Bags (envelopes, pouches) of paper or plastic, for packaging. Training, education, teaching, Education, educational information, Vocational guidance [education or training advice]; Cross-border cooperation in the fields of teaching and training; Organisation of competitions for teaching purposes, Educational examination; Academies (education), Correspondence courses, distance learning; Arranging and conducting of training workshops, colloquiums, conferences, congresses, exhibitions, seminars, symposiums and concerts, organisation of exhibitions for cultural or educational purposes, organisation of sports competitions; Publication of activity reports, books, magazines, CD-ROMs, publication of texts, other than publicity texts, online publication of electronic books and journals, lending of books; Practical training [demonstration]; Providing of sports, scientific and cultural facilities; Entertainment, providing recreation facilities, Entertainment information, Recreation information, Ticket agents services (entertainment), Production of shows, Holiday camp services (entertainment), Club services (entertainment or education), Planning (Party -) [entertainment], Sport camp services, Museum facilities (Providing -) [presentation, exhibitions], Videotape and DVD editing/ high density optical discs, Production of television and radio programs; Layout design, other than for advertising purposes, Film production services, Videotaping/ Digital versatile discs ( DVD's)/ high density optical discs, Library services, Mobile library services; Discotheques; Cinema presentations, Rental of motion pictures, Rental of sound recordings; Photographic reporting. Human and industrial scientific analysis and research in the following disciplines: the arts, plastic arts, foreign languages, foreign literature and civilisations, humanities, music, cultural and artistic activities, performing arts, visual arts, language and linguistics, philosophy, law, communication and information science and technology, marketing techniques, management of companies and administrations, economic and social administration, public administration, economics, management, economic science, accounting, checks and audits, finance, journalism, management, political science, social science, physical and sports education, geography, history, archaeology, psychology, sociology, science and techniques in the field of physical and sporting activities, theology, human resource management, anthropology, ethnology, demography, urban planning and landscaping, vocational training and science, chemistry, biology, physics, civil and industrial engineering, computing, mathematics, life sciences, earth sciences, astronomy and environmental science, agronomy, engineering science, astrophysics, bioinformatics, biophysics, biochemistry, geophysics, medical science, odontological science, health, medicine, dental surgery, pharmacy, logopaedics, orthoptics, acupuncture, maieutics; Cross-border cooperation in the field of human and industrial scientific research; Engineering, engineering drawing, Material testing, Research and development for others; Engineering services, Research in the field of environmental protection; Architecture, Interior decoration consultation, Urban planning, Construction drafting; Quality control; Computer system design, conversion of data or of documents from a physical carrier to an electronic carrier, development (design) of software, computer programming, database recovery, providing of search engines for the Internet; Authenticating works of art.

Abstract

A method for determining a characteristic of a feature in an object, the feature being disposed below a surface of the object is disclosed. The surface of the object is irradiated with a pulsed pump radiation beam so as to produce an acoustic wave in the object. The surface of the object is then irradiated with a measurement radiation beam. A portion of the measurement radiation beam scattered from the surface is received and a characteristic of the feature in the object is determined from at least a portion of the measurement radiation beam scattered from the surface within a measurement time period. A temporal intensity distribution of the pulsed pump radiation beam is selected such that in the measurement time period a signal to background ratio is greater than a signal to background ratio achieved using a single pulse of the pulsed pump radiation beam. The signal to background ratio is a ratio of: (a) signals generated at the surface by reflections of acoustic waves from the feature to (b) background signals generated at the surface by reflections of acoustic waves which have not reflected from the feature.

IPC Classes  ?

• G03F 9/00 - Registration or positioning of originals, masks, frames, photographic sheets or textured or patterned surfaces, e.g. automatically

Abstract

A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G01J 9/00 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength

Abstract

The invention provides an optical music recognition (OMR) assembly for converting sheet music, representing a music part as a first temporal representation, into a machine-processable representation of said piece of music that represents at least a pitch and duration of notes that are graphically represented in said sheet music and form said music part as a second temporal representation, said assembly comprising a data processor system and software which, when running on said data processor system: - retrieves a machine-processable representation of said sheet music; - generate a series of time slices of said sheet music, by applying a sliding window on said over said machine-processable representation of at least part of said sheet music; - defines a sequence-to-sequence system, said sequence-to-sequence system comprising: provide a convolutional neural network (CNN) for converting said time slices into a sequence of third representations of said sheet music, said CNN comprising an input layer and an output layer; provide a first, encoder recurrent neural network (RNN) as an encoder on said sequence of third representations, for providing a hidden representation of said sheet music, said first RNN having an input layer that is functionally coupled to said output layer of said CNN, and an output layer; * provide a second, decoder recurrent neural network (RNN) as a decoder to said hidden representation, for converting said hidden representation into said machine- processable representation, said second RNN having an input layer that is functionally coupled to said output layer of said first RNN, and an output for providing said machine-processable representation.

IPC Classes  ?

• G10H 1/00 - Details of electrophonic musical instruments
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/02 - Neural networks
• G10G 1/04 - TransposingTranscribing

Abstract

The invention provides a device for detecting post-traumatic stress disorder (PTSD) in a subject, comprising a data processing assembly and a computer program product which, when running on said data processing assembly: - retrieves a first dataset representative of an electromagnetic brain-related signal from a frontal brain region of said subject during a non-rapid eye movement (NREM) stage sleep; - retrieves a second dataset representative of an electromagnetic brain-related signal from an occipital brain region of said subject during a rapid eye movement (REM) stage sleep; - calculates a first frequency spectrum from said first dataset and a second frequency spectrum from said second dataset; - evaluates a neuromarker from said first frequency spectrum and said second frequency spectrum, said neuromarker providing an indication for a presence of said PTSD in said subject.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/048 - Detecting the frequency distribution of signals
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a GUCY2C agonist. The invention also relates to test systems and cells that are suited to identify new candidate compounds for the treatment of Parkinson's disease.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention provides an assembly comprising: - a recording assembly for recording a time-based brain-related signal; - a stimulus generator for providing a stimulus, and - a computer assembly, functionally coupled to said recording assembly and to said stimulus generator, said computer assembly comprising: - a memory for storing at least a data segment of said time-based brain-related signal during recording of said time-based brain-related signal, and - a computer program which, when running on said computer assembly, functionally real-time performs: - retrieving a most-recent data segment of said stored data segment of said time-based brain-related signal; - fitting at least one curve to said retrieved most-recent data segment; - predicting a future continuation of said most-recent data segment using said at least one curve fitted to said most-recent data segment; - detecting a predefined pattern in said predicted future continuation for predicting occurrence of said predefined pattern, and defining a predicted event time of said predefined pattern, said predicted event time being in the future with respect to said most-recent data segment, and - actuating said stimulus generator for providing a stimulus within a predefined event time window of said predicted event time.

IPC Classes  ?

• A61B 5/0482 - Electroencephalography using biofeedback
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia

Abstract

A method of forming a high-resolution image of a sample using a scanning microscope controlled by a processor is described wherein the method comprises the steps of receiving or generating control information for controlling a scanning microscope, the control information defining a plurality of different periodic patterns on the basis of one or more pattern parameters, preferably the one or more pattern parameters, including at least one of: a spatial frequency, a periodicity direction, an initial phase; using the control information to control the scanning microscope to expose the sample to multiple illumination patterns, each exposure to an illumination pattern causing one or more optical excitations in the sample, the light originating from said optical excitations forming an emission light signal; controlling an imaging system to capture multiple images, each image being associated with an emission light signal of one of the multiple exposures, and, using a structured light reconstruction algorithm for forming a high-resolution image on the basis of the one or more pattern parameters.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

A lithographic apparatus is a machine that applies a desired pattern onto a substrate, usually onto a target portion of the substrate. As increasing numbers of layers, using increasing numbers of specific materials, are deposited on substrates, it becomes increasingly difficult to detect alignment marks accurately, in part due to one or more of the materials used in one or more of the layers being wholly or partially opaque to the radiation used to detect alignment marks. In a first step, the substrate is illuminated with excitation radiation. In a second step, at least one effect associated with a reflected material effect scattered by a buried structure is measured in a suitable fashion. The effect may in an example comprise a physical displacement of the surface of the substrate. In a third step, at least one characteristic of the structure based on the measured effect is derived.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G03F 9/00 - Registration or positioning of originals, masks, frames, photographic sheets or textured or patterned surfaces, e.g. automatically
• G01B 17/06 - Measuring arrangements characterised by the use of infrasonic, sonic, or ultrasonic vibrations for measuring contours or curvatures

Abstract

Method and system for scanning microscopy are described. The system comprises a first optical system configured to move one or more focused illumination light spots over or through an optical active sample, the one or more focused illumination light spots causing local optical excitations in the optical active sample, the local optical excitations generating emission light. The system further comprises a second optical system configured to form at least a first emission light beam comprising first optical information and second emission light beam comprising second optical information on the basis of the emission light associated with the local optical excitations. The scanning microscopy system also comprises a lens system configured to focus the first emission light beam onto an image plane of an imaging system for forming a first image and configured to focus the second emission light beam onto the image plane of the imaging system for forming a second image. The system also comprises a moveable scanning mirror that is configured to move the focused first and second emission light beam over the image area of the imaging system when the one or more focused illumination light spots are moved over or through the sample.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

An EUV radiation source (42, 300) is used for example in a lithographic apparatus or inspection apparatus. For generating EUV radiation (302), laser radiation (304) in a second waveband is directed to a target of liquid tin fuel (69) to cause generation of a plasma. Grating radiation (328) is delivered to the target prior to and/or during delivery of the laser radiation (304), producing an electromagnetic field having a spatial distribution that includes multiple peaks and troughs across the target (406). This causes a corresponding spatial variation in a property of the target, such as the refractive index. If high enough in energy, or it may cause ablation or plasma formation in a grating pattern. By one or more mechanisms, such as surface plasmon polaritons, this periodic variation in the optical properties of the target enhances absorption of the laser energy to improve conversion efficiency of the radiation source apparatus.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

IPC Classes  ?

• C07K 1/04 - General processes for the preparation of peptides on carriers
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
• C07K 7/64 - Cyclic peptides containing only normal peptide links
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to a chimeric gene for the extracellular production in plant cells, transformed with the chimeric gene, of a pathogen effector, the chimeric gene comprising: (a) a promoter sequence which functions in plant cells; and (b) a coding sequence, operably linked to the promoter, encoding a fusion protein consisting of a pathogen effector fused in translation frame to a signal peptide for targeting said pathogen effector to the plant secretory pathway

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C07K 14/37 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi

Abstract

The invention is related to multi-chromatic photoluminescent, oxide-capped semiconductor nanocrystals and methods for forming such semiconductor nanocrystals. The method includes exposing one or more oxide-capped semiconductor, preferably type IV semiconductor, nanocrystals to electron beam radiation, wherein the radiation has an energy between 1 and 30 ke V, the radiation introducing color centers in the oxide that exhibit photoluminescence in at least the green band of the visible spectrum.

IPC Classes  ?

• C09K 11/59 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing silicon
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor

Abstract

In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G02B 21/16 - Microscopes adapted for ultraviolet illumination
• G01N 21/47 - Scattering, i.e. diffuse reflection

Abstract

A method is described for for assembling semiconductor nanocrystals comprising: - providing a binary system comprising semiconductor nanocrystals with an effective particle diameter of at most 20 nm, a first solvent, and a second solvent, - the system having * a Ta, which is which is the temperature of the system at which aggregation starts to take place, * a Ts, which is the solvent separation temperature of the system, * an aggregation temperature range, which is the range between Ta and Ts with Ta being included and Ts not being included, * a homogeneous temperature range which is below Ta when Ta is lower than Ts and which is above Ta when Ta is higher than Ts, * a heterogeneous temperature range which is above Ts when Ta is lower than Ts and below Ts when Ta is higher than Ts, and, - bringing the temperature of the binary system from a value in the homogeneous temperature range to a value in the aggregation temperature range, thereby causing formation of an aggregate of said semiconductor nanocrystals.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C09K 11/08 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials
• C30B 29/48 - AIIBVI compounds

Abstract

A multilayer reflector for use in EUV lithography, for example, comprises alternating layers of Mo and RbxSiy. The RbxSiy and Mo interface is thermodynamically stable, reducing intermingling of the layers and preventing reduction in reflectivity. The RbxSiy layer can be hydrogenated to form RbSiH3. For the case of Mo/RbSiH3 an interlayer of RbH between Mo and RbSiH3 layers can be used. An Mo/RbH multilayer mirror is also useful.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• G03F 1/24 - Reflection masksPreparation thereof
• G02B 5/08 - Mirrors
• G21K 1/06 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diffraction, refraction, or reflection, e.g. monochromators

Abstract

Some embodiments are directed to a system and a method for estimating gaze from a set of eye measurement points that are indicative of a gaze pattern of a user viewing a scene. Some other embodiments are directed to obtaining sets of eye measurement points from different users viewing the same scene. In another embodiment, the different sets of eye measurement points are mapped to a common coordinate system for reciprocal calibration In yet another embodiment, a scene transformation for mapping the common coordinate system to a coordinate system associated with the scene can be calculated by matching eye measurement points from the common coordinate system to interest points of the scene. The scene transformation is thereby calculated more accurately than individually calculated scene transformations, thereby providing a more accurate estimate of the gaze points.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The invention provides a method for recognition of information in digital image data, said method comprising a learning phase on a data set of example digital images having known information, and characteristics of categories are computed automatically from each example digital image and compared to its known category, said method comprises training a convolutional neural network comprising network parameters using said data set, in which via deep learning each layer of said convolutional neural network is represented by a linear decomposition of all filters as learned in each layer into basis functions.

IPC Classes  ?

• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G06K 9/46 - Extraction of features or characteristics of the image

Abstract

The present invention relates to compositions comprising anti-cariogenic bacteria for use in the oral cavity, which are able to minimize dental caries risk induced by sugar consumption and maintain good oral health. The compositions according to the invention comprise hydrogen peroxide- producing oral bacteria and fermentable saccharides and are able to inhibit cariogenic, acid-producing bacteria even at pH values of 5.5 or less. The probiotic compositions according to the invention are suitable for oral application and are preferably used in the oral cavity.

IPC Classes  ?

• A23G 4/12 - Chewing gum characterised by the composition containing microorganisms or enzymesChewing gum characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
• A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates

Abstract

The present invention relates to a photosensitizer comprising a porphyrin compound of the formula (I) wherein: Ar1, Ar2, Ar3 and Ar4, are each independently selected from aryl or heteroaryl, wherein each of said aryl or heteroaryl substituents may be optionally substituted, X1, X2, X3, and X4 are each independently selected from H or halogen, whereby at least one of X1, X2, X3, and X4 is halogen; X5 and X6 are each independently selected from H, hydrocarbyl or a halogen-containing group, or are linked together form an aromatic ring; X7 and X8 are each independently selected from H, hydrocarbyl or a halogen-containing group, or are linked together form an aromatic ring; and M is a metal, P or Si.

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings

Abstract

The invention pertains to a method for reduction of the cyanide content of a metals-containing wastewater fraction by contacting a wastewater fraction comprising cyanide compounds and metal compounds, with a metals content of at least 100 ppm, with hydrogen peroxide and a solid catalyst comprising at least 50 wt. % of a copper salt with a solubility of less than 10 exp (- 5) mol/liter (in water at 20°C, 1 atm). It has been found that when a solid catalyst comprising at least 50 wt. % of a copper salt with a solubility of less than 10 exp (- 5) mol/liter (in water at 20°C, 1 atm) is used in combination with hydrogen peroxide in the reduction of the cyanide content of a cyanide compound-containing wastewater fraction having a metal compound content of at least 100 ppm, a method is obtained which shows an efficient removal of cyanide compounds from a difficult to treat fraction.

IPC Classes  ?

• C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
• C02F 101/18 - Cyanides
• C02F 101/20 - Heavy metals or heavy metal compounds
• C02F 101/38 - Organic compounds containing nitrogen
• C02F 103/16 - Nature of the water, waste water, sewage or sludge to be treated from metallurgical processes, i.e. from the production, refining or treatment of metals, e.g. galvanic wastes

Abstract

The present subject matter relates to a device for trapping and eluting a liquid chromatography eluate. The device comprises a thermal modulator configured such that it may be fitted with a trapping column located at least substantially within the thermal modulator, and a temperature control unit operationally coupled to the thermal modulator. The thermal modulator has a heating, a cooling and a thermal maintenance mode. In the heating mode the thermal modulator is configured to increase the temperature of the trapping column when fitted by at least 25°C at a rate of at least 1°C per second; in the cooling mode the thermal modulator is configured to decrease the temperature of the trapping column when fitted by at least 25°C at a rate of at least 1°C per second; and in thermal maintenance mode the thermal modulator is configured to maintain the temperature of the trapping column when fitted. The device may be used in a 2D-LC system. The device may be used in a method of on-line solvent switching for an effluent from a liquid chromatography column. The device may focus analytes.

IPC Classes  ?

• G01N 30/40 - Flow patterns using back flushing
• G01N 30/46 - Flow patterns using more than one column
• G01N 30/30 - Control of physical parameters of the fluid carrier of temperature

Abstract

The invention enables estimating gaze from a set of eye measurement points which are indicative of a gaze pattern of a user viewing a scene. Herein, use is made of the insight that gaze patterns of different users are similar for a same scene (010). The invention involves obtaining different sets of eye measurement points from different users viewing the same scene. The different sets of eye measurement points may be mapped to a common coordinate system, and there by mutually calibrated, based on the assumption that geometrically similar topologies between the different sets of eye measurement points are to be mapped to similar coordinates in the common coordinate system as they represent a similar or same gaze pattern.A scene transformation for mapping the common coordinate system to a coordinate system associated with the scene can be calculated by matching eye measurement points from the common coordinate system to interest points(012) of the scene. The scene transformation is thereby calculated more accurately than individually calculated scene transformations, thereby providing a more accurate estimate of the gaze points.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The invention relates to a novel catalytic composition comprising at least one nickel precursor A with at least one diphosphinamine ligand B1 of formula (R1 )(R'1 )P-N(R3)-P(R2)(R'2) or an iminobisphosphine ligand B2 of formula (R3)N=P(R1 )(R'1 )-P(R2)(R'2) or an iminobisphosphine ligand B'2 of formula (R3)N=P(R2)(R'2)-P(R1 )(R'1 ). The invention also relates to the use of said catalytic composition in a method for the oligomerisation of olefins.

IPC Classes  ?

• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony

Abstract

The invention relates to a novel disymmetric nickel-based complex and to the method for the production thereof from at least one diphosphinamine ligand B1 of formula (R1)(R'1)P-N(R3)-P(R2)(R'2), or an iminobisphosphine ligand B2 of formula (R3)N=P(R1)(R'1)-P(R2)(R'2). The invention also relates to the use of said complex in a method for the oligomerisation of olefins.

IPC Classes  ?

• C07F 15/04 - Nickel compounds
• C08F 4/80 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from metals not provided for in group selected from iron group metals or platinum group metals
• C08F 10/02 - Ethene
• C08F 10/06 - Propene

Abstract

The invention pertains to a process for separating a mixture of alkanes which comprises straight-chain alkanes and branched alkanes, wherein the mixture is contacted with a molecular sieve under adsorption conditions resulting in adsorption of at least part of the alkane mixture onto the molecular sieve to form an adsorbed fraction, and subsequently subjecting the molecular sieve to desorption conditions thereby desorbing at least part of the adsorbed fraction from the molecular sieve, wherein the molecular sieve is a molecular sieve of ZIF-77 topology and pore size. It has been found that the use of a molecular sieve with ZIF-77 topology and pore size results in a process with a very high selectivity. More in particular, it has been found that a material with this structure shows a high adsorption selectivity, defined as the adsorbed amount of the total of straight-chain alkane and mono-methyl branched alkane divided by the absorbed amount of the total of higher-branched alkane. High adsorption selectivity leads to smaller equipment volumes, and lower capital and energy requirements.

IPC Classes  ?

• C07C 7/13 - Purification, separation or stabilisation of hydrocarbonsUse of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers by molecular-sieve technique
• C07C 9/10 - Acyclic saturated hydrocarbons with one to four carbon atoms with four carbon atoms
• C07C 9/14 - Acyclic saturated hydrocarbons with five to fifteen carbon atoms
• C07C 9/18 - Branched-chain hydrocarbons with five carbon atoms
• C07C 9/22 - Acyclic saturated hydrocarbons with more than fifteen carbon atoms
• C10G 25/03 - Refining of hydrocarbon oils, in the absence of hydrogen, with solid sorbents with ion-exchange material with crystalline alumino-silicates, e.g. molecular sieves
• C10G 53/08 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only including at least one sorption step

Abstract

The invention pertains to a process for manufacturing a glycerol-tricarboxylic acid polyester foam which comprises the steps of combining glycerol and a tri-carboxylic acid to provide a liquid reaction mixture and contacting the reaction mixture with a substrate under polymerization conditions, wherein the substrate has a top layer comprising one or more of metal, metal oxide, and metal halide. The invention also pertains to a glycerol-tricarboxylic polyester foam, in particular a glycerol-citric acid polyester foam, which has a closed cell foam structure wherein at least 90 vol.% of the foam, preferably at least 95% of the foam, is built up from cells having a diameter below 2 mm. The foamed polyester of the present invention is "green", biodegradable, and non-toxic, and can be cleanly combusted. It finds application in, int. al., packaging materials, insulation materials, and materials with a short life cycle.

IPC Classes  ?

• C08G 63/12 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
• C08G 83/00 - Macromolecular compounds not provided for in groups
• C08J 9/34 - Chemical features in the manufacture of articles consisting of a foamed macromolecular core and a macromolecular surface layer having a higher density than the core
• C08J 9/02 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by the reacting monomers or modifying agents during the preparation or modification of macromolecules

Abstract

The invention relates to a process for the oxidation of water under formation of molecular oxygen, comprising a step wherein a compound according to Formula I or a compound according to Formula II is reacted with water. The invention also relates to a compound according to Formula I and to a compound according to Formula II. The invention further relates to a solid material comprising a compound according to Formula I, and to a solid material comprising a compound according to Formula II. In particular, the invention relates to an electrode comprising a compound according to Formula I, and to an electrode comprising a compound according to Formula II.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• C01B 13/02 - Preparation of oxygen

Abstract

An activatable device (15) is provided which comprises a device (13) and an activatable imaging probe (1) attached to it. The probe comprises a chromophore (3) and an interaction moiety (5) attached to the chromophore. By interaction of a target (23) with the interaction moiety the optical properties of the probe are altered. An activatable imaging probe for attachment to such activatable device is also provided.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Ά composite material comprising 10-98 wt. % of a bio-based particulate or fibrous filler and at least 2 wt. % of a polyester derived from an aliphatic polyalcohol with 2-15 carbon atoms and a polyacid, wherein the polyacid comprises at least 10 wt. % of tricarboxylic acid. Preferably, the filler is in the form of particles, fibers, and/or random or non-random layers. A plant-based filler may be used, in particular a cellulosic or lignocellulosic material, more in particular one or more materials selected from wood chips, wood flakes, sawdust, pulp, e.g., pulp of (recycled) paper or other fiber pulp, and plant-derived fibers such as cotton, linen, flax, and hemp. An animal- derived filler, in particular an animal-derived fiber such as wool, hair, silk, or feathers may also be used. Preferably the polyacohol is selected from one or more of glycerol, sorbitol, xylitol, mannitol, 1, 2-propane diol, 1,3- propane diol, and 1, 2-ethane diol, in particular glycerol. The polyacid preferably is an aliphatic diacid or triacid with 3-15 carbon atoms. Examples of suitable acids include citric acid, succinic acid, and itaconic acid. The composite material according to the invention has fire- retardant properties, which makes it particularly suitable for applications where fire-retardancy is an issue.

IPC Classes  ?

• C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs
• C09D 167/00 - Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chainCoating compositions based on derivatives of such polymers
• C09D 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C09J 167/00 - Adhesives based on polyesters obtained by reactions forming a carboxylic ester link in the main chainAdhesives based on derivatives of such polymers
• C09J 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C08J 7/04 - Coating
• C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive

Abstract

Laminate comprising a carrier and a coating layer, wherein the coating layer is applied over at least part of the carrier, the coating layer comprising a polyester derived from an aliphatic polyalcohol with 2-15 carbon atoms and a polyacid, the coating layer having a thickness in the range of 10-4000 microns, wherein the aliphatic polyalcohol contains at least 50 mol. % of glycerol and the polyacid contains at least 30 wt. % of tricarboxylic acid. Optionally a second carrier may be applied over at least part of the coating layer. If so desired, a further coating layer is applied over at least part of the second carrier, with optional further carrier-coating stacks applied over the further carrier. Preferably the tricarboxylic acid is citric acid. The laminate according to the invention may be, e.g., a multiplex-type material. The laminate according to the invention has fire-retardant properties which makes it particularly suitable for use in applications where fire-retardancy is an issue.

IPC Classes  ?

• C09D 167/00 - Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chainCoating compositions based on derivatives of such polymers
• C09D 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C09J 167/00 - Adhesives based on polyesters obtained by reactions forming a carboxylic ester link in the main chainAdhesives based on derivatives of such polymers
• C09J 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C08J 7/04 - Coating
• C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive

Abstract

A composite material comprising 20-98 wt.% of a synthetic particulate or fibrous filler and at least 2 wt.% of a polyester derived from an aliphatic polyalcohol with 2-15 carbon atoms and a polyacid, wherein the alcohol comprises at least 50 mole% of glycerol, and the acid comprises at least 50 wt.% of tricarboxylic acid. Preferably, the filler is in the form of particles, fibers, and/or random or non-random layers. Preferably, the filler is based on one or more of ceramic, including glass, in particular glass fibers, polymer, in particular polymer fibers, and carbon, in particular carbon fibers. The use of glass fiber based sheet-like material as filler is a particular embodiment of the invention. The composite material according to the invention has fire- retardant properties, which makes it particularly suitable for applications where fire-retardancy is an issue.

IPC Classes  ?

• C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs
• C09D 167/00 - Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chainCoating compositions based on derivatives of such polymers
• C09D 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C09J 167/00 - Adhesives based on polyesters obtained by reactions forming a carboxylic ester link in the main chainAdhesives based on derivatives of such polymers
• C09J 167/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C08J 7/04 - Coating
• C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive

Abstract

A testing system with a control unit (10) connected to a plurality of sending and or receiving transducers (5, 6). In combination, the control unit (10) and transducers (5, 6) are arranged to receive a current signal originating from the sample, to calculate a fidelity index η by correlating a tail part of the current signal with a reference signal, and to compare the fidelity index η with a threshold value ηthr

IPC Classes  ?

• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G01N 29/50 - Processing the detected response signal using auto-correlation techniques or cross-correlation techniques
• G01N 29/44 - Processing the detected response signal

Abstract

The invention pertains to a process for producing a glycerol tri-carboxylic acid polyester foam which comprises the steps of combining glycerol and a tri-carboxylic acid in the liquid phase to provide a reaction mixture, and keeping the reaction mixture at a temperature of between 80°C and 130°C from the start of the reaction until a conversion of at least 90% is obtained. The foamed polyester of the present invention is "green", biodegradable, and non-toxic, and can be cleanly combusted. It finds application in, int. al., packaging materials, insulation materials, and materials with a short life cycle.

IPC Classes  ?

• C08G 63/12 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds

Abstract

A method for detecting a person's interest direction, wherein a processor performs the steps of: determine in real time an interest vector of a person from video data captured by a video camera; determine in real time a salient peak closest to the determined interest vector; determine in real time a saliency-corrected interest vector from the eyes of said person to said closest salient peak; determine in real time the deviation between the determined interest vector and the determined saliency-correctedinterestvector; determine in real time further interest vectors of said person from said video data; and calculate in real time recalibrated interest vectors by using a calibration error value calculated from said determined deviation.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The invention pertains to a diphosphine-transition metal complex comprising a diphosphine-transition metal ligand that is covalently bonded to an insoluble mesoporous support having an average pore diameter of from 4.5 nm to 50 nm, characterized in that the ligand as attached to the support has the formula: wherein R is aryl, C1-C4 alkyl, aralkyl, alkylaryl; C1-C4 alkoxy, aralkoxy, or alkylaryloxy; P is a phosphorous atom; M is a transition metal; X is a bond, CH2, 0, S or NH2; Y is C or N; A is a linking moiety which is bonded to the mesoporous support; the ring formed by X, Y and the two aromatic rings is a 5- or 6-membered ring; and wherein the aromatic rings may be unsubstituted or substituted. The invention further relates to the use of the diphosphine- transition metal complex as a catalyst in a reaction selected from hydroformylation, hydrogenation, carbonylation or carbon-carbon coupling.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• C07F 19/00 - Metal compounds according to more than one of main groups
• B01J 31/24 - Phosphines
• C07C 45/49 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide

Abstract

The present invention relates to a stereoregular copolymer having the general formula 1: (-CHR1-)n wherein the copolymer comprises a chain of n carbon atoms, each carbon atom bearing a R1 group, each R1 group being independently selected from the group consisting of: -H and hydrocarbyl-groups having between 1 and 50 carbon atoms and optionally one or more hetero atoms, and wherein the copolymer comprises at least two different R1 groups, and wherein n is an integer ranging from 50 to 1000000. The present invention also relates to a method for preparing such copolymers.

IPC Classes  ?

• C08F 2/00 - Processes of polymerisation

Abstract

A photovoltaic device is provided comprising a thin-film of an energy conversion material. The energy conversion material includes one or more quantum structures, where the quantum structures comprise a semiconductor material having an indirect band-gap in the bulk. The average size of the quantum structures is selected such that a direct and an indirect band-gaps are modified in the semiconductor material such that the direct band-gap provides charge carrier generation when the quantum structures are exposed to light.

IPC Classes  ?

• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/028 - Inorganic materials including, apart from doping material or other impurities, only elements of Group IV of the Periodic System

Abstract

The invention relates to a method for imaging an object, comprising the illumination of the object, and the detection of light coming from an area where the object is located and, based on the detected light, forming the image, with the illumination of the object taking place by distinguishing image elements in an imaging plane or space, and by separately illuminating the object parts corresponding with these image elements, while simultaneously registering the applied illumination dose of these object parts, and wherein the image is subsequently constructed by assembling the image elements corresponding with the illuminated object parts, subject to the light output and illumination doses pertaining to those image elements, wherein the illumination dose of each separate object part depends at least on a light output and/or illumination dose of another object part or several other object parts.

IPC Classes  ?

• G02B 21/06 - Means for illuminating specimen
• G02B 27/34 - Fiducial marks or measuring scales within the optical system illuminated

Abstract

A process of producing an organic compoundand/or an intermediary compound as defined herein by feeding carbon dioxide to a culture of a cyanobacterial cell and subjecting said culture to light, wherein said cell is capable of expressing a nucleic acid molecule, wherein the expression of said nucleic acid molecule confer on the cell the ability to convert a glycolytic intermediate into said organic compound and/or into said intermediary compound and wherein said nucleic acid molecule is under the control of a regulatory system which responds to a change in the concentration of a nutrient in said culture.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12P 5/02 - Preparation of hydrocarbons acyclic
• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12P 7/06 - Ethanol, i.e. non-beverage
• C12P 7/16 - Butanols
• C12P 7/18 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
• C12P 7/20 - Glycerol
• C12P 7/24 - Preparation of oxygen-containing organic compounds containing a carbonyl group
• C12P 7/28 - Acetone-containing products
• C12P 7/56 - Lactic acid

Abstract

The invention relates to a coordination complex system comprising a ligand having the formula: R1-SO2-NH-P (XR2)2 (1a); or R1-SO2-N=PH (XR2)2 (1b); or R1-SO(OH)=N-P(XR2)2 (1c); wherein X is independently O, S, NH, or a bond; R1 and R2 are independently selected from hydrogen and substituted or unsubstituted alkyl or aryl; wherein at least one equivalent of the ligand is complexed to an equivalent of a metal selected from a transition metal and lanthanide. The invention also relates to the use of said coordination complexes as catalysts in the hydrof ormylation, hydrogenation, transfer hydrogenation, hydrocyanation, polymerization, isomerization, carbonylation, cross-coupling, metathesis, CH activation, allylic substitution, aldol condensation, or Michael addition.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
• C07B 53/00 - Asymmetric syntheses

Abstract

The present invention relates to methods for inducing changes in epigenetic gene control in a chromatin domains in eukaryotic cells, and to nucleic acid constructs and host cells for use in such methods. The methods use nucleic acid constructs that are preferablyintegrated at a predetermined chromatin region of the host cell's genome, which nucleic acid construct comprise binding sites for a DNA-binding protein. Proteins that induces or are suspected to induce epigenetic gene control may then be targetedtothe integrated nucleic acid construct by means of fusion to the DNA binding protein. The targeting protein that induces or is suspected to induce epigenetic gene control to the integrated nucleic acid construct then allows to determine its effects on chromatin structure, gene expression, and epigenetic status of the chromatin locus.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The present invention discloses a method for the preparation of a polymer from vinyl group-containing monomers comprising the step of polymerizing the vinyl group-containing monomers in the presence of a metal catalyst having a moiety M2+(Y)4(X)2, wherein M is a transition metal selected from the group of Ru, Mn, Fe, Co, Zr, Rh and Os, each Y independently is a nitrogen-containing aromatic mono-ring ligand, at least one ligand Y being substituted on at least one position with a carbon-containing substituent and, optionally, either two or four ligands Y being covalently bonded to each other in pairs, and X is selected from H2O, CH3CN, (CH3) 2S0, NH3, and a mono-, di- or tri (C1-C4) -alkyl amine. The catalyst advantageously enables the synthesis of polymers with high molecular weights and low polydispersities from monomer compounds containing a vinyl group. The present invention further discloses specific novel ruthenium catalysts.

IPC Classes  ?

• C08F 12/08 - Styrene
• C08F 4/80 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from metals not provided for in group selected from iron group metals or platinum group metals

Abstract

The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the production of phosphorous compounds which process allows an easy and effective separation of the reaction products from impurities by applying a solid alkaline ion-exchange resin.

IPC Classes  ?

• C07F 9/141 - Esters of phosphorous acids
• C07F 9/6574 - Esters of oxyacids of phosphorus

Abstract

The invention is directed to a method by which the bonding strength between zirconia-based materials and other materials can be improved, and to zirconia-based materials obtainable by this method and which have improved surface properties. According to the present invention there is provided a method for increasing the bond strength between stabilized zirconia and another material, wherein said stabilized zirconia comprises ZrO2 and at least one stabilizing compound. The method of the invention results in stabilized zirconia which has an improved bond strength with other materials, which bond strength is stable with time. The surface modified stabilized zirconia of the invention can be used in prosthetic restorations, implants, solid electrolytes, fuel cells, oxygen sensors, cutting abrasives, or electrical insulators.

IPC Classes  ?

• C04B 37/00 - Joining burned ceramic articles with other burned ceramic articles or other articles by heating
• C04B 35/486 - Fine ceramics
• C04B 41/53 - After-treatment of mortars, concrete, artificial stone or ceramicsTreatment of natural stone involving the removal of part of the materials of the treated article
• C04B 41/45 - Coating or impregnating
• A61C 13/09 - Multilayer teeth
• A61C 5/08 - Tooth crowns; Making same; Securing crowns in the mouth
• A61K 6/00 - Preparations for dentistry

Abstract

The present invention describes a novel cross-linker, a method for preparing one or more cross-linked biomolecules, biomolecular complexes of two or more biomolecules, a method for preparing cross-linked fragments from such cross-linked biomolecules and/or biomolecular complexes, a method for cleavage and reduction of such cross-linked biomolecules and/or biomolecular complexes, a method for identifying cross-links in such cross-linked biomolecules and/or biomolecular complexes, as well as a method for determining relative amounts of cross-links in a biomolecule or biomolecular complex in two or more samples.

IPC Classes  ?

• C07D 207/416 - 2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms

Abstract

Method of characterizing an image comprising: defining one or more image areas of the image; analyzing color and/or intensity transitions within the image area of a predefined color basis; creating a density profile of said transitions in said image area; and fitting said density profile to a predefined parametrization function According to the method said density profile is characteristic for an image and can be used for image characterization purposes.

IPC Classes  ?

• G06K 9/64 - Methods or arrangements for recognition using electronic means using simultaneous comparisons or correlations of the image signals with a plurality of references, e.g. resistor matrix
• G06K 9/46 - Extraction of features or characteristics of the image

Abstract

A method for making dihydroxyacetone phosphate (DHAP) comprising treating dihydroxyacetone with a bacterial acid phosphatase in the presence of pyrophosphate. The invention further pertains to a method for making, preferably in one pot, stereospecif ically a compound of the formula: R-C*H(OH) -C*H(OH) -CO-CH2-OH comprising the steps: a) treating dihydroxyacetone with a bacterial acid phosphatase in the presence of pyrophosphate to make dihydroxyacetone phosphate; b) treating the dihydroxyacetone phosphate with R-CHO and an aldolase, wherein R-CHO is any aldehyde, preferably R is selected from H, unsubstituted or substituted (cyclo) alkyl , and a carbohydrate moiety, and C* stands for a chiral carbon atom to a phosphate of the formula: R-C*H(0H) -C*H(OH) -CO-CH2-OPO3H2; and c) dephosphorylating the phosphate of step b) by treating said phosphate with a bacterial acid phosphatase.

IPC Classes  ?

• C12P 7/28 - Acetone-containing products
• C12P 19/26 - Preparation of nitrogen-containing carbohydrates
• C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring

Abstract

Method of characterizing an object comprising: defining one or more image areas of the object; analyzing color and/or intensity transitions within the image area of a predefined color basis; creating a density profile of said transitions in said image area; and fitting said density profile to a predefined parametrization function According to the method said density profile is characteristic for an object and can be used for object recognition purposes.

IPC Classes  ?

• G06K 9/64 - Methods or arrangements for recognition using electronic means using simultaneous comparisons or correlations of the image signals with a plurality of references, e.g. resistor matrix
• G06K 9/46 - Extraction of features or characteristics of the image