Abstract

A vaccine for the treatment or prevention of Pseudomonas aeruginosa infection in a subject. A composition comprising one or more immunogens is provided. The composition is for use in vaccine therapy to treat or prevent P. aeruginosa infection in subject.

IPC Classes  ?

• A61K 39/104 - Pseudomonas
• C07K 14/21 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Pseudomonadaceae (F)
• C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum

Abstract

A microneedle for transdermal drug delivery, the microneedle comprising an input channel extending through the microneedle along a longitudinal axis of the microneedle, the input channel defining a sidewall, a first end, and a second end, the input channel configured to receive fluid input into the microneedle. The microneedle comprises one or more outlet channels extending between an interior surface of the sidewall, and an exterior surface of the sidewall, such that each of the one or more outlet channels define a fluid path between the input channel and the exterior surface of the sidewall. The one or more outlet channels are angled relative to the longitudinal axis of the microneedle at an angle which is greater than 0° and less than 90°.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Broadly speaking, the present techniques generally relate to a method for processing images of an organ (or part thereof) using a trained machine learning, ML, model in order to more efficiently and accurately provide information on different tissue regions of the organ. Advantageously, the ML model generates an augmented image of the organ showing the different tissue regions, such as diseased tissue regions and healthy tissue regions. This may help a surgeon to decide where to perform a surgical intervention in a way that only diseased tissue is excised.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation

Abstract

The present invention relates to diagnostic and prognostic methods and their use in diagnosing or predicting disease progression in a subject with Ulcerative Colitis (UC). More particularly, the present invention relates to a gene expression signature and the use thereof in determining the likelihood of progression of Ulcerative Colitis in a subject, as well as compositions for the detection thereof. The invention also extends to the use of biomarkers as targets to improve the treatment of Ulcerative Colitis in patients.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A fractional frequency divider configured to suppress spurious tones resulting from requantization of an accumulated quantization error has a multi-modulus divider (MMD) and one or more digital-to-time converters (DTCs). Each DTC includes a gain and/or digital predistortion, a dithered requantizer having a multibit input signa, a multibit output signal, and a multibit digitally-controllable delay (DCD). The quantized time delay between the input and output of the DTC is determined by the input from the MMD controller, the gain/digital predistortion and the requantizer. The MMD controller provides an input to the DTC that is proportional to the accumulated time quantization error introduced by the MMD controller, the gain/digital predistortion scales by a gain factor to produce a signal (a[k]) that is combined with a discrete-valued dither signal in the dithered requantizer to provide the control input of the DCD.

IPC Classes  ?

• H03K 21/08 - Output circuits
• H03K 5/00 - Manipulation of pulses not covered by one of the other main groups of this subclass
• H03K 5/1252 - Suppression or limitation of noise or interference

Abstract

1212122, and CTH assayed from a biological sample from the subject with no cancer, the individual is predicted to have an increased probability of having disease free status and having an increased chance of overall survival.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to diagnostic and prognostic methods and their use in diagnosing or predicting disease progression in a subject with colorectal cancer (CRC). More particularly, the present invention relates to a gene expression signature and the use thereof in determining the likelihood of progression of CRC to metastatic CRC (mCRC) in a subject, as well as compositions for the detection thereof. The present invention also extends to clinical markers and compositions for use in the treatment and/or prognosis of CRC and in particular mCRC.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention is concerned with an endovascular occlusion device for use in occluding a lumen of the endovascular system to treat certain medical conditions such as vascular malformations, bleeding vessels or occluding vessels in order to induce tissue ischemia or necrosis, the occlusion device including a deformable sleeve displaceable between a collapsed state and an expanded state and a conical array of cantilevered arms extending from a distal end of the sleeve and converging towards distal tips such as to define a first haemostatic valve about the distal end of the sleeve. The distal end of the sleeve will be at least partially covered with a polymer fluid impermeable membrane in order to provide a seal to prevent fluid flow through the occlusion device. The internal valve will be haemostatic regardless of the initial direction of blood flow and will allow distal endovascular delivery of a surgical instrument such as a catheter that can be manipulated and used to deliver therapeutic agents such as liquid or small particle embolics.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present disclosure describes a charging system for directing power flow between multiple devices. The charging system can include a connector box including a vehicle inlet port configured to receive a vehicle connector configured to connect to a direct current (DC) or alternating current (AC) vehicle charging station; a locking mechanism configured to secure the vehicle connector within the vehicle inlet port, wherein the locking mechanism is configured to be activated upon insertion of the vehicle connector into the vehicle inlet port and remain activated until deactivation by an authorized user; and an outlet port configured to supply electrical power received via the vehicle inlet port and to an apparatus, the apparatus configured to supply the electrical power from the outlet port to a vehicle connected to the apparatus in a vehicle charging session.

IPC Classes  ?

• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/18 - Cables specially adapted for charging electric vehicles
• B60L 53/30 - Constructional details of charging stations
• B60L 53/66 - Data transfer between charging stations and vehicles
• B60L 53/68 - Off-site monitoring or control, e.g. remote control

Abstract

Disclosed is a computer-implemented method for real-time classification of cells in a body tissue that includes capturing one or more images of a cytology slide sample of the body tissue, pre-processing the captured one or more images, detecting and extracting a plurality of regions of interest in the pre-processed images using a cell detection process, wherein each region of interest includes one or more cells or cell clusters of interest, segmenting each individual cell or cluster in the regions of interest and extracting pixel content of each segmented cell or cluster, extracting semantic features from each segmented cell image using an embedding extraction model, classifying each individual cell or cell cluster based on corresponding extracted sematic features, and predicting a class of the cytology slide sample, based on one or more positions and relationships among one or more classified cells, using a slide level decision model.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06V 10/426 - Graphical representations
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06T 7/00 - Image analysis

Abstract

This invention relates to a computer-implemented method and system for performing security evaluation on a machine learning (ML) model. The method includes determining a taxonomy of the ML model and of the environment in which the machine learning model is implemented at one or more stages in the model's lifecycle. The method additionally includes generating, based on the determined taxonomy, a set of assumptions about the ML model and the environment. An adversarial test attack is performed on the ML model at a stage in its lifecycle, based at least in part on the set of assumptions, and one or more failure modes in the ML model are identified based on the result of the first adversarial attack. The system may include a threat modelling component, an assessment component, a reporting component, and a risk mitigation component.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

The present disclosure describes a vehicle charging system comprising a vehicle charging gun comprising at least two pins, a protective earth (PE) pin configured to connect to ground and a proximity pilot (PP) pin configured to detect when the vehicle charging gun has been inserted into a vehicle; and an apparatus to couple with the vehicle charging gun, the apparatus comprising: a switch operable between a first position and a second position, the switch being controlled by a controller, wherein, when the switch is in the first position, the switch enables the vehicle or a vehicle charging station to detect that the vehicle charging gun is inserted into a vehicle inlet port of the vehicle, and when the switch is in the second position, the apparatus generates an electrical effect that simulates the removal of the vehicle charging gun from the vehicle inlet port.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 53/12 - Inductive energy transfer
• B60L 53/14 - Conductive energy transfer
• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/60 - Monitoring or controlling charging stations
• B60L 53/66 - Data transfer between charging stations and vehicles
• B60L 53/67 - Controlling two or more charging stations
• B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements
• H01R 13/639 - Additional means for holding or locking coupling parts together after engagement
• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading

Abstract

A device (1) is provided for controlling transmission of electromagnetic radiation through a transparent substrate. The device comprises a first plurality of electrodes (5a, 5b) arranged as a first layer (2) and a second plurality of electrodes (8a, 8b) arranged as a second layer (4) spaced apart from the first layer. A carrier material (6) is located between the first plurality of electrodes and the second plurality of electrodes comprising a plurality of molecules (10) configured to change their orientation in the presence of an electric field thereby to alter the transmission of electromagnetic radiation through the device. The first plurality of electrodes and the second plurality of electrodes are configured to generate an electric field in the carrier material upon application of a potential difference between the first and second plurality of electrodes, to alter the transmission of electromagnetic radiation through the device.

IPC Classes  ?

• G02F 1/169 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on orientable non-spherical particles having a common optical characteristic, e.g. suspended particles of reflective metal flakes
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance

Abstract

A computer implemented method of generating a restructured graph-based dataset (100b) of transactions within a public ledger, the method comprising: providing an original graph-based dataset (100a) of transactions within a public ledger, the original graph-based dataset (100a) comprising nodes (102, 104, 106) and edges (110, 112); determining a relatedness score for each of a plurality of pairs of nodes (102, 104, 106) in the original graph -based dataset (100a); and for each of the pairs of nodes (102, 104, 106): comparing the relatedness score to a threshold; and updating the original graph-based dataset (100a) to include a new edge (114) between the pair of nodes (102, 104, 106) if the relatedness score exceeds the threshold.

IPC Classes  ?

• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
• G06F 18/2323 - Non-hierarchical techniques based on graph theory, e.g. minimum spanning trees [MST] or graph cuts
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 5/022 - Knowledge engineeringKnowledge acquisition
• G06Q 50/26 - Government or public services
• G06Q 20/40 - Authorisation, e.g. identification of payer or payee, verification of customer or shop credentialsReview and approval of payers, e.g. check of credit lines or negative lists

Abstract

The present disclosure describes a connector box, comprising a vehicle inlet port configured to receive a vehicle connector configured to connect to a direct current (DC) or alternating current (AC) vehicle charging station; a locking mechanism configured to secure the vehicle connector within the vehicle inlet port, wherein the locking mechanism is configured to be activated upon insertion of the vehicle connector into the vehicle inlet port and remain activated until deactivation by an authorized user; and an outlet port configured to supply electrical power received via the vehicle inlet port and to an apparatus, the apparatus configured to supply the electrical power from the outlet port to a vehicle connected to the apparatus in a vehicle charging session.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 53/12 - Inductive energy transfer
• B60L 53/14 - Conductive energy transfer
• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/60 - Monitoring or controlling charging stations
• B60L 53/66 - Data transfer between charging stations and vehicles
• B60L 53/67 - Controlling two or more charging stations
• B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements
• H01R 13/639 - Additional means for holding or locking coupling parts together after engagement
• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading

Abstract

The present disclosure describes an apparatus comprising a first set of inlet ports to connect with a vehicle charging station, the first set of inlet ports configured to receive first power from a vehicle charging station; a second set of inlet ports to connect with an external power source, the second set of inlet ports configured to receive second power from the external power source; a first set of outlet ports to supply the first power from the vehicle charging station to a first vehicle in a first configuration and the second power from the external power source to the first vehicle in a second configuration; and a second set of outlet ports to direct the first power from the vehicle charging station to a second apparatus in the second configuration, wherein the second apparatus is configured to supply the first power to a second vehicle.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 53/12 - Inductive energy transfer
• B60L 53/14 - Conductive energy transfer
• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/60 - Monitoring or controlling charging stations
• B60L 53/66 - Data transfer between charging stations and vehicles
• B60L 53/67 - Controlling two or more charging stations
• B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements
• H01R 13/639 - Additional means for holding or locking coupling parts together after engagement
• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading

Goods & Services

Leadership training program consisting of leadership training, mentoring and networking; educational and training services; providing of training; entertainment; sporting and cultural activities.

Abstract

There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

IPC Classes  ?

• C07H 5/10 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium, or tellurium to sulfur
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 11/12 - Mucolytics

Abstract

There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

IPC Classes  ?

• C07H 5/10 - Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium, or tellurium to sulfur
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 11/12 - Mucolytics

Abstract

NicotianaNicotiana tabacum Nicotiana sylvestris Nicotiana sylvestris.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

A composition comprising BpPA26 is provided. The composition is for use in vaccine therapy to treat or prevent pathogenic Burkholderia species infection in a mammal, typically a human or an equine mammal. The species include Burkholderia cepacia complex, Burkholderia mallei, and Burkholderia pseudomallei.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• A61P 31/04 - Antibacterial agents
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

A composition for cell culture, the composition comprising glycosaminoglycan (GAG) having a molecular weight of from 60 to 2000 kDa, wherein the GAG has a molecular weight distribution comprising two or more peaks. Use of the composition for enhancing or influencing ECM deposition in a cell culture; or as a macromolecular crowding agent in cell culture. A cell culture medium comprising the composition. A method of eukaryote cell culture; a method of enhancing or influencing ECM deposition in eukaryote cell culture; and a method of manufacturing a cell culture medium.

IPC Classes  ?

• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The present invention relates to a compound of Formula I, Li(ox)]2[MlmM2nM3k(OH)pFq; wherein M1, M2 and M3 are metals; and X is a halogen chosen from F, Cl and Br; and m, n and k are, independently, a number between 0 and 5, the sum of m, n and k is 5; p and q are, independently, a number between 0 and 8, and the sum of p and q is 8; and to uses thereof and methods of synthesis thereof.

IPC Classes  ?

• C01G 53/00 - Compounds of nickel
• C01G 51/00 - Compounds of cobalt
• C07C 51/41 - Preparation of salts of carboxylic acids by conversion of the acids or their salts into salts with the same carboxylic acid part
• C07F 15/06 - Cobalt compounds
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy

Abstract

An optical element (100) comprises a substrate (110) and a conductive portion (120) configured to, upon application of an electrical current therethrough, generate heat through joule heating. The substrate is configured to receive heat generated in the conductive portion and, in response, undergo thermal expansion so as to change the curvature of a surface of the optical element. A method of changing the curvature of an optical element is also provided. The method comprises generating heat within the optical element so as to cause thermal expansion within the optical element.

IPC Classes  ?

• G02B 3/14 - Fluid-filled or evacuated lenses of variable focal length
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

The present invention composition relates to compositions and combination therapies for use in the prevention, management, amelioration or treatment of a cancer or RASopathy disorders in which targeted therapy is used, the composition comprising two enzyme inhibitors targeting two different conformations of an enzyme, or enzymes in the same functional family, implicated in the cancer or RASopathy disorders. The present invention also relates to methods for identifying enzyme inhibitors which may be suitable for use in treatments.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A microfluidic nucleic acid extraction chip (1), the chip (1) comprising a membrane-containing chamber (6) bonded between a first layer (2) and a second layer (3), wherein the first layer (2) comprises a sample inlet port (4) in fluid communication with the membrane-containing chamber (6) by a first microchannel (8), and a wash buffer inlet port (10) and an elution buffer waste collection port (12) in fluid communication with the membrane-containing chamber (6) by a second microchannel (14); wherein the second layer (3) comprises an elution buffer inlet port (5) in fluid communication with an eluate collection port (7) adapted to deliver extracted nucleic acid to a nucleic acid amplification module via a third microchannel (9); and wherein the membrane-containing chamber (6) is in fluid communication with the second layer (3) through an extraction microchannel (11); and the membrane-containing chamber (6) contains a silica membrane modified with a hyperbranched, cationic group.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

A computer implemented method and system for dynamically recommending footwear size includes receiving a plurality of images of a foot of a user during a current scan of the user foot, analysing the plurality of images to generate a 3D foot profile of the user, determining a foot size of the user based on the 3D foot profile, predicting a foot growth pattern of the user based on the 3D foot profile, and a user profile, recommending one or more footwear size for the user based on the foot size, the predicted foot growth pattern, one or more footwear brands and models, and predicting a time of next scan of the foot based on the recommended footwear size and the predicted foot growth pattern.

IPC Classes  ?

• G06Q 30/0601 - Electronic shopping [e-shopping]

Abstract

Disclosed is a computer-implemented method of dynamically compressing and scaling a base model during run-time, wherein the base model is a deep neural network containing a task-specific head and a backbone divided into a plurality of segments. The method includes providing a plurality of candidate early exit modules and corresponding plurality of candidate threshold values for each segment, heuristically searching a plurality of optimal early exit configurations for the base model, based on a plurality of combinations of accuracy and complexity with respect to the base model, wherein an early exit configuration enumerates which early exit module and what threshold value to be used at output of each segment, loading an optimal early exit configuration onto the base model during run-time, and running the backbone part of the base model segment by segment and ending the run-time at a segment when a confidence value of an output of corresponding early exit module exceeds corresponding threshold value.

IPC Classes  ?

• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
• G06N 3/045 - Combinations of networks
• G06N 3/0985 - Hyperparameter optimisationMeta-learningLearning-to-learn
• G06N 3/096 - Transfer learning
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The invention relates to a serine protease inhibitor (Serpin) comprising a modified Reactive Centre Loop (RCL), wherein the modified RCL comprises a transmembrane serine protease 2 (TMPRSS2) inhibitory sequence having one or more amino acid substitutions at positions P4 to P1′. The invention also relates to a method of treating and/or preventing a condition in a subject in need thereof, where the TMPRSS2 activity is implicated in said condition, the method comprising administering the Serpin of the present invention.

IPC Classes  ?

• A61K 38/55 - Protease inhibitors
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/81 - Protease inhibitors

Abstract

A method of performing hybrid electrochemical and abrasive fluid polishing is provided. The method comprised disposing (202) a workpiece to be polished and a cathode in a flow of polishing fluid, wherein the polishing fluid comprises at least one electrolyte and at least one abrasive medium. The method further comprises connecting (204) the workpiece and the cathode to an electrical power supply. An apparatus (100) is also provided for hybrid electrochemical and abrasive fluid polishing. The apparatus comprises a vessel (102) comprising an inlet (103a) and an outlet (103b) to allow a flow of fluid through the vessel. The apparatus further comprises one or more mounts (104) configured to hold a workpiece (108) to be polished in the vessel between the inlet and the outlet. The apparatus also comprises one or more connectors (106) configured to connect the workpiece and a cathode (110) to an electrical power supply.

IPC Classes  ?

• B23H 5/08 - Electrolytic grinding
• C09G 1/02 - Polishing compositions containing abrasives or grinding agents
• C25F 3/16 - Polishing
• C25F 7/00 - Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objectsServicing or operating

Abstract

A microfluidic chip (1,100) microfluidic chip (1,100) comprising at least two inlets (2, 4, 4a-4j) that meet at a junction (5, 5a, 5b) that is in fluid communication with a proximal end (3) of a channel (8, 8a, 8b, 8c) thereof and an outlet (6) that is in fluid communication with a distal end (7) of the channel (8), wherein the channel (8, 8a, 8b, 8c) comprises either a plurality of spaced-apart baffle structures (10) continuous with an inner wall (12) of the channel (8, 8a, 8b, 8c) or at least one aerofoil-shaped baffle structure (14), or a combination thereof, and forms a microchannel (9) in the channel (8, 8a, 8b, 8c) adapted to accommodate a fluid.

IPC Classes  ?

• B01F 23/41 - Emulsifying
• B01F 25/431 - Straight mixing tubes with baffles or obstructions that do not cause substantial pressure dropBaffles therefor
• B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• B01F 33/30 - Micromixers

Abstract

The present invention relates to a system for measurement of peripheral aberration of the human eye. The system is characterized by a specially designed multifaced mirror having its each face distributed along an elliptical contour. The normal to any point on the elliptical contour bisects an angle formed by the point and the line connecting the two focal points of the elliptical contour. The length of the multifaced mirror is equal to the length of a line segment formed between the intersections of a plurality of tangents drawn at each intersection of the elliptical contour and a plurality of rays. The plurality of rays extends from a focal point at the centre of the entrance pupil to a plurality of other focal points at the centre of the entrance pupil. Each ray has a predetermined difference in gradient with respect to each other adjacent ray.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes

Abstract

A molecular evaluation method for predicting the molecular mechanisms through which a perturbation promotes or inhibits a cellular transition from a first cell state to a second cell state. Cells are clustered in a multi-dimensional representation to identify distinct cell states, with dimensions corresponding to molecular features, which are ranked according to a vector component directed towards a separating hypersurface. Core network components are identified with the highest ranking and a reduced dimension space is used, without the core component dimensions, to assess the effects of perturbations in terms of a Dynamic Phenotype Descriptor (DPD) which represents the remainder of the global network on which the core network acts. Bayesian Modular Response Analysis is used to reconstruct the topology and signs and strengths of causal connections between nodes of the core network and the DPD. A resulting mechanistic model based on ordinary differential equations (ODE) is derived that calculates the quality and quantity of changes which are needed to convert one cell state into another permitting interventions to be identified that will promote or inhibit particular cell transitions.

IPC Classes  ?

• G16B 5/20 - Probabilistic models
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/20 - Supervised data analysis

Abstract

Disclosed is a system and method for assessing spectral residual viability (SRV) and corresponding remaining shelf life (RSL) of a food product, comprising capturing one or more images of the food product by a camera; analysing the one or more images to perform a visual assessment of a plurality of individual attributes of the food product, using respective plurality of vectoral algorithms; estimating a Quality Index (QI) of the food product based on an average summation of each individual analysis of each individual IE attribute; receiving a future storage temperature at which the food product is stored or transported; estimating a SRV and corresponding RSL of the food product based on the QI and the future storage temperature. The present invention provides a system and method that has the functional capability to merge both biologic product specific degradation models with user defined predicted consequence to predict SRV and corresponding RSL of the product.

IPC Classes  ?

• G06V 20/68 - Food, e.g. fruit or vegetables
• G01N 33/02 - Food
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands

Abstract

The present invention provides a tear stimulation device and method for delivering thermal energy at controlled rates to stimulate the creation of a natural tear by activating the thermo-receptors on the sensory nerves of the eye and extended orbital region, modulation of the thermal energy resulting in controlled, repeated tearing to provide a naturally lubricated and nourishing environment in which the ocular surface can heal.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Disclosed is a video summarisation method that includes converting an input video file to a video transcript using speech recognition, segmenting the video transcript into a plurality of paragraphs using a transformer based model, performing relevance ranking of the plurality of paragraphs by assigning a paragraph importance score to each paragraph, based on relevance of each paragraph to an overall content of the video transcript, creating a plurality of candidate summaries from the plurality of paragraphs, each candidate summary comprising two or more paragraphs, performing coherence reranking of the plurality of candidate summaries based on a combination of coherence and relevance of each candidate summary, and selecting a summary based on the coherence reranking.

IPC Classes  ?

• H04N 21/8549 - Creating video summaries, e.g. movie trailer
• G06F 40/40 - Processing or translation of natural language
• G10L 15/26 - Speech to text systems

Abstract

An imaging device comprising: an electromagnetic radiation, EMR, source, configured to provide first EMR, preferably monochromatic EMR, having a first wavelength in a range from 0.1 μm to 3 μm, preferably in a range from 0.4 μm to 1.4 μm, more preferably in range from 0.75 μm to 0.85 μm, most preferably in range from 780 nm to 805 nm, for example about 785 nm; a set of flexible fibre-optic bundles, including a first fibre-optic bundle, having respective proximal ends and distal ends, wherein the proximal end of the first fibre-optic bundle is optically coupled to the EMR source and wherein the distal end of the first fibre-optic bundle is flexibly positionable and/or orientable to illuminate a target with the first EMR, incident thereupon, provided by the EMR source; and an EMR detector configured to detect second EMR, having a second wavelength in a range from 0.1 μm to 3 μm, preferably in a range from 0.4 μm to 1.4 μm, more preferably in range from 0.80 μm to 0.85 μm, most preferably in range from 810 nm to 830 nm, for example about 825 nm, emitted by the illuminated target and to output signals corresponding to the detected second EMR.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres

Abstract

The present disclosure relates to a system and method for treating wastewater, the method comprising the steps of: providing a vessel for receiving wastewater and a gas, wherein the gas comprises one or more constituent gas components; directing the wastewater and a first gas component of the gas to the vessel; reducing the temperature of the contents of the vessel from a first temperature to a second temperature to facilitate the formation of clathrate hydrates comprising the wastewater and the first gas component; increasing the temperature of the contents of the vessel with respect to the second temperature to facilitate melting of the clathrate hydrates; and removing clean water and/or the first gas component from the vessel.

IPC Classes  ?

• B01F 33/05 - Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
• B01F 23/23 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
• B01F 23/411 - Emulsifying using electrical or magnetic fields, heat or vibrations
• B01F 31/00 - Mixers with shaking, oscillating, or vibrating mechanisms
• B01F 35/21 - Measuring
• B01F 35/92 - Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
• C02F 1/22 - Treatment of water, waste water, or sewage by freezing
• C02F 3/28 - Anaerobic digestion processes

Abstract

The present invention relates to a host cell. The host cell finds utility as a biosensor by comprising at least one nucleic acid modification in the nucleic acid sequence of at least one gene. Also disclosed is the host cell for use as a biosensor, use of the host cell as a biosensor, a method of producing a biosensor, and a method of identifying the presence, absence or quantity of an analyte in a sample.

IPC Classes  ?

• C07K 14/245 - Escherichia (G)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• C12R 1/19 - Escherichia coli

Abstract

A method and a generator for producing nanobubbles or nanodroplets at ambient conditions; the method comprising: providing a volume for accommodating a liquid; distributing a medium within the liquid, wherein the medium is provided to the volume at ambient conditions; generating an electric field using an electrode in the proximity of the volume for facilitating the generation of nanobubbles or nanodroplets; wherein the electrode and the liquid are not in direct electrical contact to prevent electrolysis occurring within the volume.

IPC Classes  ?

• B01F 23/23 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
• B01F 23/2375 - Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids characterised by the physical or chemical properties of gases or vapours introduced in the liquid media for obtaining fine bubbles, i.e. bubbles with a size below 100 µm for obtaining bubbles with a size below 1 µm
• B01F 33/05 - Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
• B01F 35/21 - Measuring
• B01F 35/90 - Heating or cooling systems
• C02F 1/22 - Treatment of water, waste water, or sewage by freezing

Abstract

A method of discriminating between a first tissue status and a second tissue status of an organ or a part thereof, the method implemented by a computer comprising a processor and a memory, the method comprising: obtaining a first time series of images, including a first image and a second image, of the organ, having a set of spatial regions including a first spatial region, having the first tissue status, and a second spatial region, during a first time period after a first perfusion of the organ with a first contrast agent and before controlling perfusion of the organ; generating a first set of intensity-time profiles of the set of spatial regions, including a first intensity-time profile of the first spatial region, using respective intensities of the set of spatial regions of the first time series of images; obtaining a second time series of images, including a first image and a second image, of the organ, during a second time period after a second perfusion of the organ with a second contrast agent and after controlling perfusion of the organ; generating a second set of intensity-time profiles of the set of spatial regions, including a first intensity-time profile of the first spatial region and a second intensity-time profile of the second spatial region, using respective intensities of the set of spatial regions of the second series of images; comparing the first set of intensity-time profiles and the second set of intensity-time profiles; and discriminating between the first spatial region and the second spatial region based on a result of comparing the first set of intensity-time profiles and the second set of intensity-time profiles.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

The present invention is concerned with an endovascular occlusion device for use in occluding a lumen of the endovascular system to treat certain medical conditions such as vascular malformations, bleeding vessels or occluding vessels in order to induce tissue ischemia or necrosis, the occlusion device including a deformable sleeve displaceable between a collapsed state and an expanded state and a conical array of cantilevered arms extending from a distal end of the sleeve and converging towards distal tips such as to define a first haemostatic valve about the distal end of the sleeve. The distal end of the sleeve will be at least partially covered with a polymer fluid impermeable membrane in order to provide a seal to prevent fluid flow through the occlusion device. The internal valve will be haemostatic regardless of the initial direction of blood flow and will allow distal endovascular delivery of a surgical instrument such as a catheter that can be manipulated and used to deliver therapeutic agents such as liquid or small particle embolics.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord

Abstract

Protein agglomeration is inhibited in a protein-containing liquid, within an industrial processing plant, using a microwave resonance cavity having an inlet conduit and an outlet conduit. The liquid is transported into and out of the cavity, and while within the cavity, it is exposed to a microwave electromagnetic field. This field exposure reduces the tendency of proteins within the liquid to agglomerate, and inhibits coagulation or protein deposition for an extended period of time after leaving the cavity.

IPC Classes  ?

• A23C 3/07 - Preservation of milk or milk preparations by irradiation, e.g. by microwaves

Abstract

Disclosed is a recurrent DVR model and a DVR based recurrent neural network for generating a non-linear output signal. The recurrent DVR model includes a magnitude recurrent filter that comprises a recurrent neural network for combining a magnitude of a current input signal with previous sequence information of the magnitude recurrent filter in a recurrent manner, to generate an intermediate output magnitude, a phase recurrent filter that comprises a recurrent neural network for combining a phase of a current input signal with previous sequence information of the phase recurrent filter in a recurrent manner, to generate an output phase, a DVR module for performing a DVR operation on the intermediate output magnitude to generate an output magnitude, and a multiplier for multiplying the output magnitude with cos and sine components of the output phase to generate cos and sine magnitude components of the non-linear output signal respectively.

IPC Classes  ?

• H03F 3/34 - DC amplifiers in which all stages are DC-coupled
• H03F 1/32 - Modifications of amplifiers to reduce non-linear distortion
• H03F 3/24 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers of transmitter output stages
• H03F 1/02 - Modifications of amplifiers to raise the efficiency, e.g. gliding Class A stages, use of an auxiliary oscillation
• H03F 1/00 - Details of amplifiers with only discharge tubes, only semiconductor devices or only unspecified devices as amplifying elements

Abstract

A vaccine comprising one or more VTEC immunogens. The vaccine is for use in vaccine therapy to treat or prevent VTEC infection in a mammal and for use in vaccine therapy to treat or prevent HUS in a mammal. A method of diagnosing VTEC infection in a subject is also provided.

IPC Classes  ?

• A61K 39/ -
• A61P 1/ -

Abstract

A surface preparation method (200) for a composite material (104) having an original surface (110), the material (104) comprising fibres (104a) within a matrix (104b), comprises removing (204) a surface portion of the matrix (104b) by plasma ablation so as to reveal and activate (206) a new surface (120) with at least a portion of a plurality of the fibres (104a) exposed thereon, without creating a residual heat-affected zone.

IPC Classes  ?

• H01J 37/02 - Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof Details
• H01J 37/32 - Gas-filled discharge tubes

Abstract

A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

An effective amount of a Saccharomyces cerevisiae-derived (1→3)-β-D-glucan particle for use in a method to program bone marrow hematopoietic stem and progenitor cells (HSPC) to promote multipotent progenitor (MPPs) expansion in favour of myelopoiesis in a subject.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61P 37/04 - Immunostimulants

Abstract

The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress β1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins
• C12N 9/10 - Transferases (2.)
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Abstract

A sensor device (300) comprises a direct or indirect light source (310). The sensor device further comprises a light angle sensor (320) configured to measure the angle and of incident light from the light source. The sensor device also comprises a deformable element (330) configured to support the light source at a position above the light angle sensor so as to direct light onto the light angle sensor. The device is configured to detect displacement of the light source and/or a reference point in or on the deformable element relative to the light angle sensor based, at least in part, on a change in the measured incident light angle produced by a deformation of the element that displaces the light source from a rest position.

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes

Abstract

A microneedle for transdermal drug delivery, the microneedle comprising an input channel extending through the microneedle along a longitudinal axis of the microneedle, the input channel defining a sidewall, a first end, and a second end, the input channel configured to receive fluid input into the microneedle. The microneedle comprises one or more outlet channels extending between an interior surface of the sidewall, and an exterior surface of the sidewall, such that each of the one or more outlet channels define a fluid path between the input channel and the exterior surface of the sidewall. The one or more outlet channels are angled relative to the longitudinal axis of the microneedle at an angle which is greater than 0˚ and less than 90˚.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Serious gaming for interrelated critical infrastructure (CI) resilience improvement includes receiving from a serious gaming participant a selection of an anomalous event for a geographic region for which a hierarchy of CI elements has been modeled, and a specified change in allocation of at least one resource in a corresponding one of the CI elements. A previously determined cascading impact upon the CI elements resulting from the anomalous event is then retrieved and compared to a hypothetical cascading impact produced by a simulation of the model with the specified change. A visualization of the comparison is transmitted to the serious gaming participant so as to show the result of the hypothetical change in resources upon the cascading impact of the event in the hierarchy of CI elements.

IPC Classes  ?

• G06Q 50/26 - Government or public services

Abstract

Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• B60L 53/12 - Inductive energy transfer
• B60L 53/60 - Monitoring or controlling charging stations
• B60L 53/67 - Controlling two or more charging stations
• H01R 13/639 - Additional means for holding or locking coupling parts together after engagement
• B60L 53/16 - Connectors, e.g. plugs or sockets, specially adapted for charging electric vehicles
• B60L 53/10 - Methods of charging batteries, specially adapted for electric vehiclesCharging stations or on-board charging equipment thereforExchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
• B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements
• B60L 53/66 - Data transfer between charging stations and vehicles
• B60L 53/14 - Conductive energy transfer
• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading

Abstract

A heating system (1) for use with a 3D printer, the heating system (1) comprising an infrared heat source (20) that is configured to be proximal to a printhead (500) of the 3D printer, wherein the infrared heat source (20) is configured to (a) heat the material as it is extruded from the printhead (500) and deposited on a substrate, and to (b) apply heat in form of a heat footprint (22) to an area below the printhead (500), including the substrate and the deposited material, after the material is deposited and starts to cool.

IPC Classes  ?

• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B29C 64/209 - HeadsNozzles
• B29C 64/295 - Heating elements
• B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
• H05B 1/02 - Automatic switching arrangements specially adapted to heating apparatus
• H05B 3/40 - Heating elements having the shape of rods or tubes

Abstract

A composition comprising a polymer and a salt of a pharmaceutical compound, wherein the salt is an ionic liquid is described. A solid dosage form comprising such a composition, and a method of preparing the composition are also described.

IPC Classes  ?

• A61K 31/4164 - 1,3-Diazoles
• A61K 31/37 - Coumarins, e.g. psoralen
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline

Abstract

A process for producing a bio-based surfactant comprising an alkyl disulphate salt comprises the steps of methanolysis of medium chain length polyhydroxyalkanoic acid (mcl-PHA) to provide hydroxy fatty acid methyl ester monomers (HFAME's), reduction of the HFAME's to provide 1,3 alkyl diols, sulphation of the 1,3 alkyl diols to provide 1,3 alkyl disulphates, and neutralisation of the alkyl disulphates to provide a bio-based surfactant comprising 1,3 alkyl disulphate salt. A bio-based surfactant comprising a mixture of medium chain length 1,3 alkyl disulphate salts is also described.

IPC Classes  ?

• A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• A61Q 5/02 - Preparations for cleaning the hair
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A61Q 19/10 - Washing or bathing preparations
• C07C 303/24 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
• C11D 1/16 - Sulfonic acids or sulfuric acid estersSalts thereof derived from divalent or polyvalent alcohols
• C12P 7/6409 - Fatty acids

Abstract

Embodiments of the present invention provide a method, system and computer program product for tiered data sharing privacy assurance in responding for requests to inspect investigative data. In an embodiment of the invention, a method for tiered data sharing privacy assurance in responding for requests to inspect investigative data includes receiving a request to access investigative data and applying a privacy test to the request to determine if the request is specific for an individual or generic to any individual. On condition that the privacy test is determined to be generic, the request may be denied. But otherwise, on condition the test is determined to be specific, a data sharing rule that defines a degree to which the investigative data is to be shared may be applied and the request responded to according to the defined degree.

IPC Classes  ?

• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

Abstract

A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of ( 1 + ∑ i = 1 K c i ⁢ z - i ) A digital delta-sigma modulator (DDSM) is disclosed with an input signal x[n], an output signal y[n], a quantization error signal e[n] and a dither signal d[n], having an equation described in the z-domain by Y(z)=STF(z)X(z)+DTF(z)D(z)−NTF(z)E(z) wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: NTF ⁡ ( z ) = Az - Q ( 1 + ∑ i = 1 K c i ⁢ z - i ) where A, Q and K are constants, coefficients ci are real valued and cK≠0 and wherein at least one of the zeroes zj of ( 1 + ∑ i = 1 K c i ⁢ z - i ) satisfies zj≠+1 for j=1, 2, . . . , K

IPC Classes  ?

• H03M 3/00 - Conversion of analogue values to or from differential modulation

Abstract

A device (1) is provided for controlling transmission of electromagnetic radiation through a transparent substrate. The device comprises a first plurality of electrodes (5a, 5b) arranged as a first layer (2) and a second plurality of electrodes (8a, 8b) arranged as a second layer (4) spaced apart from the first layer. A carrier material (6) is located between the first plurality of electrodes and the second plurality of electrodes comprising a plurality of molecules (10) configured to change their orientation in the presence of an electric field thereby to alter the transmission of electromagnetic radiation through the device. The first plurality of electrodes and the second plurality of electrodes are configured to generate an electric field in the carrier material upon application of a potential difference between the first and second plurality of electrodes, to alter the transmission of electromagnetic radiation through the device.

IPC Classes  ?

• G02F 1/169 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on orientable non-spherical particles having a common optical characteristic, e.g. suspended particles of reflective metal flakes
• G02F 1/17 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on variable-absorption elements not provided for in groups
• G02F 1/19 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on variable-reflection or variable-refraction elements not provided for in groups
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance

Abstract

A window system for controlling the transmission of thermal radiation from an external source of electromagnetic radiation comprises a windowpane (101, 103) comprising a transparent substrate, a first electrode layer (2) and a second electrode layer (4). A carrier material (6) is located between the first and second electrode layers comprising a plurality of molecules (10) orientable in the presence of an electric field. A processor (503) is configured to determine a position of an external source of electromagnetic radiation, calculate a direction of incidence of the electromagnetic radiation, determine electrodes in the first and second electrode layer to apply a potential difference between, and apply a potential difference between the determined electrode in the first electrode layer and the determined electrode in the second electrode layer.

IPC Classes  ?

• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
• E06B 3/67 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges characterised by additional arrangements or devices for heat or sound insulation
• G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells

Abstract

Disclosed is a method of pruning an artificial neural network (ANN) that includes recording activations of the ANN on an input dataset that includes a plurality of data inputs of a plurality of classes, scoring each neuron of the ANN based on a class-separation ability of a neuron in corresponding activations, and pruning the one or more neurons based on the scoring. The scoring of a neuron comprises computing a plurality of activation scores of a neuron for corresponding plurality of data inputs for each class, calculating a class centre of the neuron based on an average value of the plurality of activation scores for said class for each class, calculating a set of Euclidean distances for the neuron, for corresponding sets of class pairs, wherein a Euclidean distance is distance between class centres of corresponding pair, and calculating a class-separation score of the neuron, wherein the class-separation score is a median value of the plurality of Euclidean distances.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

wherein Y(z), X(z), D(z) and E(z) are z-transforms of the output signal, the input signal, the dither signal, and the quantization error signal, and wherein STF(z), DTF(z) and NTF(z) correspond to a transfer function of the input signal, a transfer function of the dither signal, and a transfer function of the quantization error signal, and wherein the transfer function of the quantization error signal is of the form: j of j≠+1 for j=1, 2, . . . , K.

IPC Classes  ?

• H03M 7/32 - Conversion to or from delta modulation, i.e. one-bit differential modulation
• H03M 7/36 - Conversion to or from differential modulation with several bits, i.e. the difference between successive samples being coded by more than one bit

Abstract

The present invention relates to a compound of Formula I, Li(ox)]2[M1mM2nM3k(OH)pFq; wherein M1, M2 and M3 are metals; and X is a halogen chosen from F, Cl and Br; and m, n and k are, independently, a number between 0 and 5, the sum of m, n and k is 5; p and q are, independently, a number between 0 and 8, and the sum of p and q is 8; and to uses thereof and methods of synthesis thereof.

IPC Classes  ?

• C07F 15/06 - Cobalt compounds
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• C07C 53/00 - Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
• C07C 55/06 - Oxalic acid
• C01G 51/00 - Compounds of cobalt
• C01G 53/00 - Compounds of nickel

Abstract

Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.

IPC Classes  ?

• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
• A61P 31/14 - Antivirals for RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to a method of diagnosing and/or prognosing preeclampsia. Specifically, the method involves determining the quantitative level of one or more biomarkers in a biological sample from the subject and either diagnosing preeclampsia; prognosing unstable moderate early-onset preeclampsia; and/or diagnosing preeclampsia and prognosing unstable moderate early-onset preeclampsia in the subject.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to proteins and protein libraries particularly for use in methods of screening to identify novel binding partners including diagnostic and therapeutic molecules.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Goods & Services

Promoting and raising public awareness of the importance of the bioeconomy and the production, utilization and conservation of biological resources; promoting and raising public awareness of the importance of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; promoting and raising public awareness of the use of biotechnology in the production of bio-based goods and services from biological material; administrative services, namely, organising and administering grant applications; administrative services, namely, administering peer review of research proposals; administrative services, namely, organising and administering grant schemes, and research programmes in respect of which grants have been made; administrative services, namely, organising and administering research and educational programmes in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; administrative services, namely, administration and management of research grants; administrative services, namely, management of grant funding for research programs in respect of which grants have been made; administrative services, namely, management of grant funding for the research and educational programs of others in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; business consultancy and advisory services. Providing grants, awards and other financial sponsorship in the fields of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; raising funds for research in the fields of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering and research in the foregoing areas; provision of finance and grant aid; funding and investment in relation to research and development; financial assistance and financial aid in research development projects; providing financial grant applications; assessing proposals for research projects for the purpose of making financial grants; providing funding for symposia, seminars and courses of instruction related to environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering subject matter and intellectual property. Treatment and conversion of organic materials; Treatment and conversion of organic materials into energy sources using biological processes and agents; Conversion of plant and animal waste into energy sources; Conversion of plant and animal waste into useable products; waste treatment (conversion); treatment, transformation, recycling and recovery of wastes and bioresources; consultancy in the field of energy production. Education; Education services relating to the bioeconomy and the production, utilization and conservation of biological resources; Education and training relating to nature conservation and the environment; Education in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering; educational services, namely, assessing proposals for research projects and ongoing assessments and review of research projects; provision of training in the field of environmental conservation, bioconversion, science, technology, innovation and engineering; arranging and conducting workshops in respect of research techniques and in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering generally; symposia, seminars and courses of instruction related to scientific subject matter, intellectual property and/or the importance of environmental conservation, science, technology, innovation and engineering generally; publication of books, newspapers, magazines, pamphlets, periodicals and other printed matter, texts and databases in the fields of environmental conservation, bioconversion, science, technology, innovation and engineering; issuing of awards and conducting award ceremonies in the field of environmental conservation, bioconversion, science, technology, innovation and engineering; providing peer review of educational research proposals; providing assessment of educational research projects. Providing assistance and aid in the nature of expert advice and recommendations to Governmental and regulatory organisations in relation to research and development projects; providing peer review in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; providing a database of information relating to environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering in the nature of descriptions of funded projects and reports of progress made on funded projects; providing ongoing review and assessments of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering research projects; Research in the field of environmental conservation, bioconversion, science, technology, biotechnology, innovation and engineering; Professional consultancy relating to the conservation of energy; consultancy in the field of energy-saving and energy use; agricultural research services; laboratory services. Agricultural, horticulture and forestry services; Providing information about agriculture, horticulture, and forestry services; Consultancy and advisory services relating to agriculture, horticulture and forestry; agricultural services relating to environmental conservation.

Abstract

The present invention relates to a method for multivariate spatial data analysis of agricultural fields to provide actionable insights into spatial variability. The method is based on the spatial and temporal correlations of multiple localised parameters. The method comprises the step of combining a historical yield frequency map of a spatially contiguous set of regions with two or more Normalized Difference Vegetation Index (NDVI) maps of the regions from an ongoing cropping season, using multivariate geostatistical techniques such as Geographically Weighted Regression (GWR) model, wherein the latest captured NDVI map is the response variable, and the NDVI maps captured prior to the latest captured NDVI maps and the historical yield frequency map are the explanatory variables. Based on the parameter surface for each explanatory variable for the entire field, regions of interest such as under/over performance or variable performance can be identified. The method further provides a mean of automatically identifying the relative local weightings of each conflated data layer in relation to yield at each point across a field.

IPC Classes  ?

• G06V 20/13 - Satellite images
• G06V 20/10 - Terrestrial scenes
• G06T 7/00 - Image analysis

Abstract

A computer implemented method and system for dynamically recommending footwear size includes receiving a plurality of images of a foot of a user during a current scan of the user foot, analysing the plurality of images to generate a 3D foot profile of the user, determining a foot size of the user based on the 3D foot profile, predicting a foot growth pattern of the user based on the 3D foot profile, and a user profile, recommending one or more footwear size for the user based on the foot size, the predicted foot growth pattern, one or more footwear brands and models, and predicting a time of next scan of the foot based on the recommended footwear size and the predicted foot growth pattern.

IPC Classes  ?

• A43D 1/02 - Foot-measuring devices
• G06Q 30/06 - Buying, selling or leasing transactions

Abstract

The present disclosure relates to a phase-locked loop (PLL) based on a charge-sharing locking technique, capable of both fractional-N and integer-N operation. The PLL comprises a voltage pre-setting stage; an oscillator: a shared capacitive load; and a switching network configured for selectively connecting the voltage pre-setting stage to the shared capacitive load during a voltage pre-setting stage for applying an expectant voltage to the capacitive load. The switching network is being further configured for selectively connecting the capacitive load to the oscillator during a charge-sharing locking stage for correcting a phase error in response to a difference between the expected voltage of the capacitor and the voltage of the oscillator. Frequency-tracking and waveform-learning stages are also provided for maintaining PVT (process, voltage, temperature) robustness and for suppressing fractional-N spur, respectively.

IPC Classes  ?

• H03L 7/099 - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
• H03L 7/04 - Automatic control of frequency or phaseSynchronisation using a frequency discriminator comprising a passive frequency-determining element wherein the frequency-determining element comprises distributed inductance and capacitance
• H03L 7/085 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal

Abstract

A clinical decision support system and method provides a practitioner with an indication of individual specific prospective usefulness of a referral. The practitioner is provided with individual-specific indication of prospective usefulness of findings for a referral, wherein comparative and statistical input data is supplemented by nuanced data to predict the usefulness of findings from optional and/or select subsequent diagnostic tests relative to individual specific propensity for a condition/disease.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

The invention relates to a method of determining the likelihood of an individual transitioning to a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of the individual transitioning to a first episode of psychosis (FEP). The invention also relates to a method of predicting the functional outcome for an individual following a first episode of psychosis (FEP), the method comprising determining the level of selected markers in a bodily fluid sample from the individual, wherein the increase or decrease in the markers is predictive of an increased risk of functional disability outcome for the individual.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a system for measurement of peripheral aberration of the human eye. The system is characterized by a specially designed multifaced mirror having its each face distributed along an elliptical contour. The normal to any point on the elliptical contour bisects an angle formed by the point and the line connecting the two focal points of the elliptical contour. The length of the multifaced mirror is equal to the length of a line segment formed between the intersections of a plurality of tangents drawn at each intersection of the elliptical contour and a plurality of rays. The plurality of rays extends from a focal point at the centre of the entrance pupil to a plurality of other focal points at the centre of the entrance pupil. Each ray has a predetermined difference in gradient with respect to each other adjacent ray.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
• A61B 3/14 - Arrangements specially adapted for eye photography

Abstract

38 ABSTRACT REMOTE MONITORING OF RESPIRATION 5 A computer-implemented method is provided for characterising breathing audio data. The method/system comprises acquiring breathing audio data. The method/system further comprises determining an estimated respiration rate based on the breathing audio data. The method/system also comprises identifying exhales in the breathing audio data using the estimated respiration rate. One or more computer-readable storage media are10 also provided comprising instructions that, when executed by a computer, cause the computer to determine an estimated respiration rate based on breathing audio data, and identify exhales in the breathing audio data using the estimated respiration rate. [To be accompanied, when published, by Figure 1 of the drawings.]15

IPC Classes  ?

• A61B 7/00 - Instruments for auscultation
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

Hyperbranched cationic polymers are described. The polymers employ a 4-branching monomer resulting in an increase in the number of functional terminal groups due to the extra branching units, providing excellent transfection efficiency and cytocompatibility in different cell types, including aADSC, HeLa, Neu7 and RDEB keratinocytes, and delivering different genetic therapy approaches such GFP plasmid DNA and a ribonucleoprotein CRISP-Cas 9 complex for COL7A1 exon 80 skipping. In addition, the extra branching units of the polymer of the invention increases the positive charge on the polymer, which provides for improved endosomal escape within the cell. The 4-branching unit can be a diamine component, or a tetraacrylate component, although other 4-branching monomers may be employed such as for example any component with tetra acrylamide groups (i.e. 4-arm PEG acrylamide, 4-arm PEG maleimide), any component with tetra N- hydroxysuccinimide (NHS) groups (i.e. 4-arm PEG-succinimidyl carbonate NHS ester), any type of tetrathiol component (i.e. Pentaerythritol tetrakis(3-mercaptopropionate), 4-arm PEG-thiol, Tetra(2- mercaptoethyl)silane), and any tetraepoxy component (i.e. TetraGlycidyl methylenedianiline, Tetraglycidyl 1, 1′-methylenebis(naphthalene-2,7-diol), Pentaerythritol tetraglycidyl ether, 4-arm peg epoxide).

IPC Classes  ?

• C08G 73/02 - Polyamines
• C08G 63/685 - Polyesters containing atoms other than carbon, hydrogen, and oxygen containing nitrogen
• C08G 83/00 - Macromolecular compounds not provided for in groups
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

A method of performing hybrid electrochemical and abrasive fluid polishing is provided. The method comprised disposing (202) a workpiece to be polished and a cathode in a flow of polishing fluid, wherein the polishing fluid comprises at least one electrolyte and at least one abrasive medium. The method further comprises connecting (204) the workpiece and the cathode to an electrical power supply. An apparatus (100) is also provided for hybrid electrochemical and abrasive fluid polishing. The apparatus comprises a vessel (102) comprising an inlet (103a) and an outlet (103b) to allow a flow of fluid through the vessel. The apparatus further comprises one or more mounts (104) configured to hold a workpiece (108) to be polished in the vessel between the inlet and the outlet. The apparatus also comprises one or more connectors (106) configured to connect the workpiece and a cathode (110) to an electrical power supply.

IPC Classes  ?

• C25F 3/16 - Polishing
• B23H 5/08 - Electrolytic grinding
• C25F 3/24 - Polishing of heavy metals of iron or steel
• C25F 3/26 - Polishing of heavy metals of refractory metals
• H01L 21/321 - After-treatment

Abstract

A continuous liquid-liquid phase separator (100) comprising a porous insert (101) housed concentrically within a non-permeable outer tube (102), the outer tube (102) having an inside surface (103), and wherein the configuration of the outer tube (102) and porous insert (101) form an annular gap (104) therebetween.

IPC Classes  ?

• B01D 63/06 - Tubular membrane modules
• B01D 71/36 - Polytetrafluoroethene

Abstract

A molecular evaluation method for predicting the molecular mechanisms through which a perturbation promotes or inhibits a cellular transition from a first cell state to a second cell state. Cells are clustered in a multi-dimensional representation to identify distinct cell states, with dimensions corresponding to molecular features, which are ranked according to a vector component directed towards a separating hypersurface. Core network components are identified with the highest ranking and a reduced dimension space is used, without the core component dimensions, to assess the effects of perturbations in terms of a Dynamic Phenotype Descriptor (DPD) which represents the remainder of the global network on which the core network acts. Bayesian Modular Response Analysis is used to reconstruct the topology and signs and strengths of causal connections between nodes of the core network and the DPD. A resulting mechanistic model based on ordinary differential equations (ODE) is derived that calculates the quality and quantity of changes which are needed to convert one cell state into another permitting interventions to be identified that will promote or inhibit particular cell transitions.

IPC Classes  ?

• G16B 5/10 - Boolean models
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The present invention provides a tear stimulation device and method for delivering thermal energy at controlled rates to stimulate the creation of a natural tear by activating the thermo-receptors on the sensory nerves of the eye and extended orbital region, modulation of the thermal energy resulting in controlled, repeated tearing to provide a naturally lubricated and nourishing environment in which the ocular surface can heal.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
• A61F 7/02 - Compresses or poultices for effecting heating or cooling

Abstract

Mycobacterium tuberculosisMycobacterium bovis (M. bovis)Mycobacterium bovis (M. bovis) and other intracellular mycobacterial pathogens. In particular the invention relates to a panel of biomarkers which indicate increased gene expression that is indicative of tuberculosis infection in a subject. Suitably such a panel may allow advantageous characterisation of an infection status of a subject, for example an animal, for example cattle.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

The present invention provides a tissue anchor and a system and method employing same, the anchors including a body having a first section and a second section reversibly engagable with one another, each section including a plurality of barbs in the form of microneedles projecting from the underside therefore, the barbs on one section being inclined towards barbs on the other section, such that tissue may be captured and deformed between the barbs through displacement of the first section relative to the second section in order to achieve robust retention of the tissue anchor at a deployment site.

IPC Classes  ?

• A61B 17/064 - Surgical staples
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A lung perfusion solution comprises a base solution comprising a physiological mixture of electrolytes and buffers, 3.5-5.5% (w/v) a first macromolecule having a molecular weight of 40-100 KDa, and an amount of a second, high molecular weight, macromolecule sufficient to adjust the relative viscosity of the solution to 2.0-3.0.

IPC Classes  ?

• A01N 1/165 - Pressure processes, e.g. following predefined pressure changes over time
• A01N 1/126 - Physiologically active agents, e.g. antioxidants or nutrients
• A01N 1/143 - Apparatus for organ perfusion

Abstract

A nanoparticulate composition comprises a gene editing ribonucleoprotein system complexed within a cationic polymer. The cationic polymer may be a Poly-beta amino ester hyperbranched polymer, especially a 4-branching hyperbranched polymer. The gene editing ribonucleoprotein system may be a CRISPR-Cas9 gene editing system configured to excise a mutation or exon in a gene, replace a mutation in a gene, or produce a knock-down or knock-out of a gene, and in particular configured to excise exon 80 of the COL7A1 gene which codes for the collagen VII protein. Data shows that using

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• A61K 9/51 - Nanocapsules

Abstract

Cannabis sativaCannabis sativaCannabis sativa plant is grown under continuous light conditions; providing a flower induction, pollination and seed setting period during which the plant is grown under short-day conditions; and providing a seed-ripening period during which the plant is grown under continuous light and water stress conditions. The vegetative growth period is a period of from 10 to 30 days and the flower induction, pollination and seed-setting period is a period of from 21 to 35 days.

IPC Classes  ?

• A01G 7/00 - Botany in general
• A01G 22/00 - Cultivation of specific crops or plants not otherwise provided for

Abstract

The invention provides a method of preparing a silica-protein sub-micron particle, the method comprising contacting, in an aqueous medium having a pH in the range of about 7.5 to 10 and having an ionic strength in the range of about 1.2 to 60 mM, (i) protein sub-micron particle cores comprising 0.2 to 3 μmoles, per mg of the protein sub-micron particle cores, of a basic compound of formula (I) or an ester and/or amide thereof wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3, with (ii) orthosilicic acid or an ester thereof, in an amount equivalent to 5 to 60% (w/w) orthosilicic acid per mg of the protein sub-micron particle cores, to form the silica-protein sub-micron particle. The invention also provides a method of making a GLP-1 receptor agonist sub-micron particle core, by a. contacting a peptide in an aqueous medium at a pH of about 5.0-8.0 and comprising about 0.3-1.3 mM peptide, wherein the peptide is a GLP-1 receptor agonist, with the above-mentioned basic compound of formula (I) or an ester and/or amide thereof: wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3; in a molar ratio between the peptide and the basic compound of from 1:about 20 to 1:about 90 to form a step a. reaction mixture having a pH of about 7.5 to 10.0; optionally about 9.5; b. contacting the step a. reaction mixture with zinc to form a step b. reaction mixture, wherein the ratio of peptide:basic compound:zinc in the step b. reaction mixture is 1:about 20 to 110:9 to 30; whereby the GLP-1 receptor agonist sub-micron particle core is formed. The invention also provides a method of making an insulin sub-micron particle core, the method comprising the steps of: a. contacting insulin in an aqueous medium having a pH of less than about 6.0 and comprising about 0.50 to about 1.50 mg/mL insulin, with the aforementioned basic compound of formula (I) or an ester and/or amide thereof; in a molar ratio between the insulin and the basic compound of from about 1:40 to about 1:140 to form a step a. reaction mixture having a pH of about 7.5 to 10; b. contacting the step a. reaction mixture with zinc to form a step b. reaction mixture, wherein the molar ratio of insulin:zinc in the step b. reaction mixture is 1:about 0.5 to about 10; whereby the insulin sub-micron particle core is formed.

IPC Classes  ?

• A61K 38/28 - Insulins
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 38/26 - Glucagons
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

An imaging apparatus for imaging a sample (7) comprises an array of electronically addressable pixels (6) wherein each pixel is arranged to support a surface plasmon resonance therein to generate an evanescent electromagnetic field. This field extends transversely from the pixel so as to be salient from the array at a first side of the array for illuminating the sample at said first side. A light source (15) is arranged to illuminate the array with excitation light therewith to generate said surface plasmon resonance. An optical detector (12A, 12B, 12C) is arranged at a second side of the array which is opposite to said first side of the array for detecting optical radiation returned from the array in response to illumination of the array by said excitation light. A processing unit (4) is arranged to associate the detected optical radiation with the address of the pixel or pixels within the array at which the surface plasmon resonance was generated.

IPC Classes  ?

• G01N 21/552 - Attenuated total reflection
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed herein is a method of treating a substance use disorder in a subject suffering from sustained substance exposure, comprising: administering to the subject a therapeutically effective amount of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), or a pharmaceutically acceptable derivative or salt thereof.

IPC Classes  ?

• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 25/30 - Drugs for disorders of the nervous system for treating abuse or dependence
• A61P 39/02 - Antidotes

Abstract

A method (100) of determining the temporal occurrences of one or more events characterising movement of a person is provided. The method comprises processing (102) kinematic data relating to movement of the person to determine the temporal occurrences of the events. The processing of the kinematic data comprises processing the kinematic data using the Teager-Kaiser energy operator. A system for measuring the temporal occurrences of one or more events characterising movement of a person is also provided.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

The present application relates to a surgical delivery device (10) suitable for submucosal dye delivery or for introduction or extraction of fluidic or gaseous material into or from tissue (T), the surgical delivery device comprising an elongate main body (12) defining an evacuatable chamber (18) internally thereof, a lateral window (20) in the body in communication with the chamber and a guideway (24a) extending through the body and into the chamber.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 17/34 - TrocarsPuncturing needles
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

Protein agglomeration is inhibited in a protein-containing liquid, within an industrial processing plant, using a microwave resonance cavity having an inlet conduit and an outlet conduit. The liquid is transported into and out of the cavity, and while within the cavity, it is exposed to a microwave electromagnetic field. This field exposure reduces the tendency of proteins within the liquid to agglomerate, and inhibits coagulation or protein deposition for an extended period of time after leaving the cavity.

IPC Classes  ?

• A23C 3/07 - Preservation of milk or milk preparations by irradiation, e.g. by microwaves
• A23L 3/01 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by heating using irradiation or electric treatment using microwaves or dielectric heating

Abstract

Computer implemented methods for calculating configurational energy of a system with periodic boundary conditions having a plurality of particles are described. In an embodiment the method comprises steps of defining a cut-off radius defining a non-electrostatic interaction potential cut-off distance between particles in the system; defining a set of cell vectors to generate a simulation cell; defining a set of supercell vectors to generate a supercell that comprises a plurality of replicas of the simulation cell; calculating, for each particle located within the supercell, non-electrostatic pair potentials between the particle and any and all additional particles surrounding the particle within the cut-off radius, said non-electrostatic pair potentials resulting from the interaction of the particle with any and all other particles located within the cut-off radius; and summing all distinct non-electrostatic pair potentials to provide a non-electrostatic configurational energy of the system.

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G16C 20/50 - Molecular design, e.g. of drugs
• G06F 30/20 - Design optimisation, verification or simulation

Abstract

A broadband power amplifier circuit is disclosed for providing load modulation, and includes an active element for receiving an impedance matched signal and for amplifying the impedance matched signal to supply an amplified signal, and an output matching network having a load impedance and coupled to the active element for receiving the amplified signal, the output matching network matches the load impedance to an optimum load impedance of the active element.

IPC Classes  ?

• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
• H03F 1/02 - Modifications of amplifiers to raise the efficiency, e.g. gliding Class A stages, use of an auxiliary oscillation
• H03F 3/24 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers of transmitter output stages
• H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics

Abstract

A whole (1→3)-β-D-glucan particle for treating or preventing a hepatic metabolic condition associated with obesity or diabetes in a subject is provided. The method comprises administering an effective amount of a whole (1→3)-β-D-glucan particle to said subject. The glucan is β-1,6 branched β-1,3 glucan.

IPC Classes  ?

• A61K 31/716 - Glucans
• A23L 33/14 - Yeasts or derivatives thereof
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A composition comprising a polymer and a salt of a pharmaceutical compound, wherein the salt is an ionic liquid is described. A solid dosage form comprising such a composition, and a method of preparing the composition are also described.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/37 - Coumarins, e.g. psoralen
• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Abstract

The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress β1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Abstract

The invention provides a method of prognosing and/or diagnosing heart disease or heart failure in a subject, comprising determining the methylation status and/or expression level of at least one methylation marker selected from the group consisting of MFSD2B, miR24-1, TTPA, GALNT15, ITGBL1, SMOC2, MSR1, PVT1, MYOM3, COX17, MYBPC3, HEY2, and MRPL44 wherein the methylation status and/or expression level of at least one methylation marker is indicative of the prognosis and/or diagnosis of said subject. A panel of biomarkers, means, a kit and a device for use in assessing risk of HCM, ISCM and DCM are disclosed.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention relates to a device for use in the delivery of an active agent. Specifically, the present invention relates to a device comprising a scaffold that can be formed from a polymer or co-polymer; a matrix; and at least one active agent. The device finds utility in the delivery of at least one active agent, and is useful in methods of reducing cell infiltration, inflammation and collagen deposition in a tissue or treating fibrosis in a tissue. In an aspect, the device can alleviate post-operative inflammation and/or fibrosis; and can also improve patient compliance for effective delivery of an active agent.

IPC Classes  ?

• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/20 - Polysaccharides
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 31/04 - Macromolecular materials
• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 31/14 - Materials characterised by their function or physical properties
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention provides a fractional-N frequency synthesizer comprising a divider controller comprising a multistage noise Shaping (MASH) digital delta-sigma modulator comprising L error feedback modulator (EFM) stages, wherein the jth EFM stage is configured to receive as an input the sum of the error of the preceding EFM stage and a high amplitude dither signal derived from the error of the kth EFM stage, where 1≤j≤k≤L.

IPC Classes  ?

• H03L 7/197 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop using a frequency divider or counter in the loop a time difference being used for locking the loop, the counter counting between numbers which are variable in time or the frequency divider dividing by a factor variable in time, e.g. for obtaining fractional frequency division
• H03M 3/00 - Conversion of analogue values to or from differential modulation

Abstract

A method of analysing a target bodily tissue of a subject. The method involves manipulating image data from the target bodily tissue and a background bodily tissue after dosing the subject with a contrast agent. The relative intensities of the light emitted from selected areas of the target bodily tissue and background bodily tissue at different time points after dosing are compared to determine whether 1) the intensity of light emitted from the target bodily tissue is lower than the intensity of light emitted from the background bodily tissue during the first part of the time period; and/or 2) the intensity of light emitted from the target bodily tissue is higher than the intensity of light emitted from the background bodily tissue during the second part of the time period; to assist in the determination of whether the target bodily tissue is benign or malignant.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements