Abstract

A signal generator is provided that is configured to generate a signal adapted to be delivered to the brain of a subject to alleviate nausea in the subject. The stimulation signal is defined by a waveform having a frequency and a phase. The stimulation signal is characterized by one or more instantaneous disruptions of the phase of the waveform. A system (100) for alleviating nausea is provided. The system (100) comprises: the signal generator (102) configured to generate the stimulation signal; and one or more electrodes (104, 106a-c) configured to deliver the stimulation signal to the brain of a subject.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

The present invention relates to a method of optimising an instruction set for a chemical synthesis and a chemical synthesiser for use in a method of optimising an instruction set for a chemical synthesis. The method comprises (i) performing a chemical synthesis in a reaction vessel of a chemical synthesiser operating according to an instruction set to produce a reaction product, (ii) recording reaction data using an analytical unit of the synthesiser during the chemical synthesis and/or recording product data on the reaction product, (iii) analysing the reaction data and/or product data using a control unit of the chemical synthesiser to determine a characteristic of the synthesis; and (iv) adjusting one or more reaction parameters of the instruction set, to provide an adjusted instruction set, based on a prediction that the adjustment will improve the characteristic of the synthesis.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

Abstract

The invention provides a method for the exploration of chemical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product has a superior fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical inputs. Each reaction in the second series differs in one or more chemical and/or physical inputs. The invention also provides an automated exploration apparatus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

IPC Classes  ?

• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• C40B 40/00 - Libraries per se, e.g. arrays, mixtures
• C40B 50/00 - Methods of creating libraries, e.g. combinatorial synthesis
• C40B 60/02 - Integrated apparatus specially adapted for creating libraries, screening libraries and for identifying library members

Abstract

A method for the dielectrophoretic assembly of nanowires onto a substrate, including the steps: (i) providing a suspension of nanowires in a carrier liquid; (ii) providing a substrate; (iii) providing an array of electrodes on an electrode array support; (iv) bringing the substrate into proximity with the electrode array support at a first surface of the substrate; (v) locating at least a second surface of the substrate, opposite to the first surface, in the suspension of nanowires; and (vi) applying a voltage signal to the array of electrodes. Accordingly, there is generated, through the substrate, a corresponding electric field in the suspension of nanowires and a dielectrophoretic force on the nanowires in the suspension of nanowires. This causes dielectrophoretic assembly of nanowires onto the second surface of the substrate in an arrangement corresponding to the array of electrodes.

IPC Classes  ?

• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H10K 85/00 - Organic materials used in the body or electrodes of devices covered by this subclass
• B03C 5/00 - Separating dispersed particles from liquids by electrostatic effect
• B03C 5/02 - Separators
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions

Abstract

The invention relates to the field of medicine, in particular of cardiology. The present invention is based on the identification of Runx 1 as a therapeutic target in heart failure with preserved ejection fraction (HFpEF)and addresses the pressing need for HFpEF therapies. Accordingly, the present invention relates to novel methods for the prophylaxis and treatment of HFpEF, and particularly, although not exclusively, to Runxf inhibitors for use in the prophylaxis and treatment of HFpEF. The invention provides methods of prophylaxis or treatment of HFpEF and compounds and compositions for use in those methods.

IPC Classes  ?

• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure

Abstract

The present invention relates to a gel composition comprising: (a) a supramolecular gel formed from or comprising a network of one or more low molecular weight gelators (LMWGs) in an aqueous solution; wherein the supramolecular gel: (i) has a storage modulus (G') of from 100 to 1,000,000 Pa; (ii) has a loss modulus (G'') such that G''/G' is from 0.01 to 0.5; and (iii) has a breakage strain of from 0.1 to 300%. Additionally, the invention relates to processes for preparing such gel compositions. The present invention also relates to a gel composition comprising an encapsulated component, processes for preparing such gel compositions and processes relating to storing, transporting and extracting such encapsulated components.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• C08L 101/14 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
• A61K 9/06 - OintmentsBases therefor
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• C08J 3/075 - Macromolecular gels

Abstract

A computer-implemented method for upscaling the resolution of an image which uses a co-registered pair of images comprises a first image having a first resolution and a second image having a second resolution that is lower than the first resolution. The method determines local or global relationships between the images, and generates an upscaled version of the second image (a super-resolved image) using the local or global relationships and the pixel data of the first image. Embodiments of the invention may be applied to any imaging modalities, for example the first image and the second image may be derived from two different imaging modalities (e.g., images based on different wavelengths). For example, the first image may comprise a high-resolution intensity image and the second image may comprise a lower-resolution fluorescence lifetime imaging microscopy image.

IPC Classes  ?

• G06T 3/4053 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution

Abstract

An antenna system comprising: a receiving antenna section configured to receive a wireless radio frequency signal; and a rectifier system connected to the receiving antenna section by a primary transmission line that is configured to convey the radio frequency signal received by the receiving antenna section. The rectifier system is configured to convert the received radio frequency signal into a direct current power signal. The antenna system further comprises: a processing unit configured to be powered by the direct current power signal from the rectifier system; and a coupler configured to capacitively couple a portion of the radio frequency signal conveyed by the primary transmission line for processing by the processing unit without passing through the rectifier system.

IPC Classes  ?

• H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
• H01Q 1/24 - SupportsMounting means by structural association with other equipment or articles with receiving set
• H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
• H02J 50/27 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves characterised by the type of receiving antennas, e.g. rectennas

Abstract

Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

IPC Classes  ?

• A61K 35/68 - Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

IPC Classes  ?

• C07D 215/48 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 51/04 - Organic compounds

Abstract

A neural microprobe is disclosed. The neural microprobe comprises a stacked structure having a base layer, a core layer, a metal layer, and a ceiling layer. The base layer is formed from a first species of biocompatible polymer. The core layer is formed from a second species of biocompatible polymer deposited on the base layer. The metal layer is deposited on the core layer. The ceiling layer is formed from the first species of biocompatible polymer deposited on the metal layer and comprises a plurality of trenches etched through the ceiling layer to expose portions of the metal layer, said exposed portions defining electrodes of an electrode array of the neural microprobe. The first species of biocompatible polymer has a lower coefficient of thermal expansion than the second species. A method of manufacturing a neural microprobe comprises providing a first mask on the ceiling layer, wherein the first mask is lithographically patterned to define a plurality of gaps in the first mask; providing a second mask on the first mask; etching, with a first etchant, through the second mask and the gaps in the first mask, trenches in the ceiling layer to expose the portions of the metal layer defining the electrodes of the electrode array; and etching, with a second etchant, the stacked structure to remove any remaining portions of the first and second masks, and to release a base layer of the stacked structure from the release layer.

IPC Classes  ?

• A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A bioelectronics system is provided. The bioelectronics system comprises an implant device having multiple pairs of electrodes integrated therein and an implantable control electronics module. The implantable control electronics module comprises: a multiplexer configured to enable a separate signal to be independently applied across each pair of electrodes, a microcontroller, and a wireless communication module. The implantable control electronics module further comprises either: (i) an impedance analyser configured to measure a respective complex impedance across each pair of electrodes, wherein the microcontroller is configured to encode the measured complex impedances as complex impedance information, and the wireless communication module is configured to transmit the complex impedance information to a remote unit for analysis; or (ii) a waveform generator configured to apply respectively determined waveform profiles across each pair of electrodes, wherein the microcontroller is configured to determine the respective waveform profiles to be applied across each pair of electrodes based on instructions received, from a remote unit and by the wireless communication module, to deliver an electrical signal across the multiple pairs of electrodes.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
• A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
• A61N 1/375 - Constructional arrangements, e.g. casings

Abstract

The invention relates to an apparatus and methods for performing air-sensitive and/or water-sensitive reactions autonomously, for example with an automated chemical synthesiser. The automated chemical synthesiser comprises a first reactionware in fluid communication with a reagent manifold, a vacuum line and a gas line, wherein the synthesiser further comprises a control unit for automatically and independently controlling fluid communication of the reactionware with the reagent manifold, vacuum line and gas line, and the gas line is for the supply of anaerobic and/or anhydrous gas. The synthesiser is operable to provide an anaerobic and/or anhydrous environment, such as atmosphere, within a reactionware, such that chemical syntheses which are sensitive to oxygen and/or water may be performed in the reactionware.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01J 3/00 - Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matterApparatus therefor
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01J 4/00 - Feed devicesFeed or outlet control devices
• B01J 19/24 - Stationary reactors without moving elements inside

Abstract

A coil array for use with a magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is disclosed. The coil array comprises no more than eight transmitter coils arranged around a central axis of the coil array in first and second circumferential rows that are respectively positioned proximal to the head and neck of a patient when in use and are displaced longitudinally along the central axis with respect to each other. A coil assembly for use with a magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is also disclosed. The coil assembly comprises the disclosed coil array and a receiver coil array. A magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is disclosed. Said apparatus comprises the disclosed coil assembly.

IPC Classes  ?

• G01R 33/34 - Constructional details, e.g. resonators

Abstract

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

IPC Classes  ?

• A01N 37/46 - N-acyl derivatives
• A01N 47/44 - GuanidineDerivatives thereof
• A01P 7/04 - Insecticides
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BR-CA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.

IPC Classes  ?

• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Abstract

Described herein are molecules and compounds for use in medicine, as medicaments and for the treatment or prevention of cardiac diseases.

IPC Classes  ?

• A61K 38/46 - Hydrolases (3)
• A61K 38/08 - Peptides having 5 to 11 amino acids

Abstract

The invention relates to protein bacteriocins (PBs) as therapeutic agents, and specifically to protein complexes comprising two or more PB molecules associated with a protein scaffold which comprises cognate immunity protein domains for the effector portions of the respective PBs. In particular, the invention provides an anti-bacterial protein complex comprising (a) a first PB molecule and a second PB molecule; and (b) an immunity protein scaffold comprising a first immunity protein domain and a second immunity protein domain; wherein the first and second immunity protein domains are non-covalently bound to the respective first and second PB molecules.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/21 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Pseudomonadaceae (F)
• C07K 14/24 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
• C07K 14/245 - Escherichia (G)
• C07K 14/255 - Salmonella (G)
• C07K 14/26 - Klebsiella (G)
• C07K 14/265 - Enterobacter (G)
• C12N 9/22 - Ribonucleases
• C12N 9/96 - Stabilising an enzyme by forming an adduct or a compositionForming enzyme conjugates
• C12N 15/62 - DNA sequences coding for fusion proteins
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/46 - Hydrolases (3)
• A61P 31/04 - Antibacterial agents

Abstract

There is disclosed an apparatus (100) and method for determining a fluorescence lifetime of a sample (102), the apparatus comprising an interferometer (106). The method comprises interfering, by a beam splitter (110) of the interferometer (106), a fluorescence signal from a sample (102) received along a first arm (108a) of the interferometer with a reference pulse (118) received along a second arm (108b) of the interferometer (106). The reference pulse (118) has a frequency selected to interfere with the fluorescence signal. The method further comprises outputting, by a first photon detector (134a) that receives a first combined signal output from the beam splitter (110), a first detection signal indicative of the number of photons in the first combined signal; outputting, by a second photon detector (134b) that receives a second combined signal output from the beam splitter (110), a second detection signal indicative of the number of photons in the second combined signal; and determining the fluorescence lifetime of the sample (102) based on a correlation between the first and second detection signals over a range of relative path delays between the first and second arms (108a,108b) of the interferometer (106).

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/64 - FluorescencePhosphorescence

Abstract

There is provided a method and a system for determining an activity being performed by a person and/or monitoring occupancy in an environment. The environment comprises a plurality of passive RFID tags. The method comprises: receiving, over a sample period, in response to an interrogation signal, one or more response signals from one or more of the passive RFID tags; determining, for each passive RFID tag, a normalised count value based on a number of response signals received from said passive RFID tag over the sample period; and using a machine learning algorithm to determine the activity being performed in the environment and/or monitor occupancy of the environment. The machine learning algorithm is configured to take the normalised count values as inputs, and determine, based on the normalised count values, the activity or occupancy during the sample period.

IPC Classes  ?

• G06Q 10/02 - Reservations, e.g. for tickets, services or events
• G06Q 10/10 - Office automationTime management
• G06Q 50/40 - Business processes related to the transportation industry
• G06K 17/00 - Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups , e.g. automatic card files incorporating conveying and reading operations

Abstract

The invention relates to polypeptides, in particular polypeptides comprising a diyne linkage. The invention provides a polypeptide of Formula (I), a polypeptide and amino acids for the preparation of the diyne linked polypeptides, and methods for the preparation of the diyne linked polypeptides. The invention also provides medical uses of the polypeptides.

IPC Classes  ?

• A61K 38/12 - Cyclic peptides
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The invention relates in general to the field of CAR-T cells. The invention in particular relates to improved methods for obtaining CAR-T cells, and improved CAR-T cells, as well as uses thereof. The method in further relates to activating or expressing a phosphodiesterase (PDE) in T-cells during CAR-T cell generation.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C07K 14/725 - T-cell receptors
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 15/86 - Viral vectors

Abstract

A granular material conveyance apparatus [100] comprises a discharge conduit [102] comprising a proximal end [102a] configured to receive granular material from a granular material source and a distal end [102b] separated from the proximal end [102a] along a longitudinal direction of the conduit [102]. The discharge conduit [102] is movable with respect to the granular material source. An end effector [110] is engaged externally with respect to the discharge conduit [102] so as to be translatable along the longitudinal direction of the discharge conduit [102]. The discharge conduit [102] further comprises a conveyor [106] configured to move the granular material along a conveyance path [108] disposed within the discharge conduit [102] from the proximal end [102a] towards the distal end [102b] of the discharge conduit [102]. The end effector [110] has an inlet [112] in communication with the conveyance path [108] at least at a plurality of positions of the end effector [110] with respect to the discharge conduit [102] to allow the granular material to be conveyed from the discharge conduit [102] and into the end effector [110]. Also disclosed is a method and apparatus for transferring granular material between a filling module [202] and a receiving module [204].

IPC Classes  ?

• B65G 33/22 - Screw or rotary spiral conveyors for fluent solid materials comprising a screw or screws enclosed in a tubular housing with means for retarding material flow at the delivery end of the housing
• B65G 33/14 - Screw or rotary spiral conveyors for fluent solid materials comprising a screw or screws enclosed in a tubular housing
• B65G 33/24 - Screw or rotary spiral conveyors Details

Abstract

The present invention concerns a structurally distinct immunosuppressive mimic of TGF-β that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-β mimic which fully replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 14/495 - Transforming growth factor [TGF]
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

The invention relates to a product for use in the treatment, prevention or amelioration of prostate cancer in a subject in need thereof, wherein the product induces the expression of PDE4D7 or promotes activity of phosphodiesterase 4D7. The product may be a direct or indirect activator of PDE4D7 activity or a product for expressing or promoting expression of PDE4D7 in a subject. The invention further defines a kit of parts and an in vitro or ex vivo use of the product.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 35/00 - Antineoplastic agents
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

Abstract

nrr , nii Qrr , Qii i ) and normalized three-dimensional magnetization vector (I) are accurately obtained.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties

Abstract

A biomagnetic sensor that incorporates an integrated active noise cancellation unit that uses a gradiometer to remove ambient magnetic noise from a detection signal obtained from a tunnelling magnetoresistive (TMR) sensor unit that is indicative of a magnetic field adjacent to biological tissue. The ambient magnetic noise can thus be removed in real time at a front end of the sensor (e.g. as part of circuity in the sensor body itself). The active noise cancellation technique proposed herein may be effective enough to enable the biomagnetic sensor to be used in an unshielded environment (i.e. an environment that is subject to the Earth's magnetic field, for example), which widens significantly the potential uses for the sensor.

IPC Classes  ?

• A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
• A61B 5/248 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoneurographic [MNG] signals, e.g. magnetospinographic [MSG] signals
• A61B 5/305 - Common mode rejection
• A61B 5/30 - Input circuits therefor
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a method and apparatus for performing and characterising a chemical synthesis, such as those performed with an automated chemical synthesis platform, including such that are portable platforms, the method comprising the steps of: performing a chemical synthesis in a chemical synthesiser; recording analytical data during the chemical synthesis, and developing a profile for the analytical data recorded over time; and comparing the profile for the chemical synthesis against a reference profile, which reference profile is the analytical data recorded over time for a reference chemical synthesis, wherein the chemical synthesis and the reference chemical synthesis share at least the same reagents and method steps for the same intended product, such as the chemical synthesis and the reference chemical synthesis sharing the same instruction set. The method and apparatus are for intended for use in replication of approved, chemical syntheses based on common reaction platforms.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Goods & Services

Software; Internet of Things [IoT] sensors; Internet of Things [IoT] gateways; computer hardware modules for use with the Internet of Things [IoT]; computer application software for use in implementing the Internet of Things [IoT]; development kits; software development kits; sensors; imaging apparatus. Business advisory services; business project management. Education; training. Software as a Service [SaaS]; product development; product development consultation; research and development services; scientific and technological consulting; engineering services; design and development of prototypes; technical research in the field of computer vision; laboratory testing services; engineering testing services; design of integrated circuits; design of electric circuit boards.

Abstract

The disclosed invention relates to a method for identifying biomarkers for the stratification of hypertensive patients among different hypertension diseases: endocrine forms of hypertension and primary hypertension. The method is a machine-learning based method using one trained classifier on a predefined input dataset to rank several combinations of omics biomarkers (miRNA, steroids, metanephrines, small metabolites) on the basis of the computation of at least one evaluation parameter. A combination of biomarkers is selected to stratify the hypertensive patient among said plurality of hypertension diseases. Also, the disclosed invention relates to a method for stratifying hypertensive patients, such as hypertensive patients with endocrine forms of hypertension (EHT). The method comprises operating a trained classifier on a combination of biomarkers determined from the hypertensive patient to stratify the hypertensive patient among several types of hypertensive patients such as endocrine forms of hypertension and primary hypertension.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Plants modified to exhibit reduced plasticity and related methods and compositions are disclosed. The plants have reduced developmental plasticity in response to changes in light and temperature conditions, and exhibit additional features such as earlier, more consistent and uniform flowering regardless of changes in day length and temperature, and reduced listing in the field.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• C12N 5/04 - Plant cells or tissues
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A01H 1/00 - Processes for modifying genotypes
• A01H 3/00 - Processes for modifying phenotypes
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases

Abstract

The invention relates to the treatment of chronic myeloid leukemia (CML). In particular it relates to the treatment of CML with inhibitors of mitochondrial pyruvate transport, which are able to target leukemic stem cells (LSCs) which are resistant to therapy with tyrosine kinase inhibitors (TKIs). Combination therapies with BCR-ABL kinase inhibitors are also described.

IPC Classes  ?

• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides methods for reducing a nitro compound using a mediator, such as a polyoxometalate. A method of the invention comprises oxidising a reduced mediator to yield a mediator, and reducing a nitro compound as a first step; whilst reducing the mediator to yield a reduced mediator as a second step, which reduced mediator is subsequently used in the first step.

IPC Classes  ?

• C25B 3/09 - Nitrogen containing compounds
• C25B 3/25 - Reduction

IPC Classes  ?

• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• G16C 20/80 - Data visualisation
• G16C 20/90 - Programming languagesComputing architecturesDatabase systemsData warehousing

Abstract

The invention relates to a method for generating a database for chemical syntheses and a method for performing a chemical synthesis using a database. The method for generating a database comprises generating a series of instruction sets for a series of chemical syntheses from the literature, wherein each instruction set is a machine readable and executable universal language for a chemical synthesiser; assembling the series of instructions sets within a database, and making the instruction sets available for access and autonomous execution by a chemical synthesiser. The method for performing a chemical synthesis comprises accessing an instruction set from a database, providing the instruction set to a chemical synthesiser, and autonomously executing the instruction set on the chemical synthesiser thereby to perform the chemical synthesis. The invention makes use of a standardised and step-focussed syntax to describe the chemical syntheses, and a universal synthesis automation platform.

IPC Classes  ?

• G16C 20/80 - Data visualisation
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• G16C 20/90 - Programming languagesComputing architecturesDatabase systemsData warehousing

Abstract

The present invention relates to solute carrier proteins as targets for cancer therapy. In particular, it relates to the inhibition of serine transport by two or more solute carrier proteins. The compositions, uses and methods of the present invention have utility in the treatment of cancer.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents

IPC Classes  ?

• G01N 21/55 - Specular reflectivity
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

Abstract

A localised surface plasmonic sensing device is disclosed. This comprises: a substrate; a first, second, third and fourth (at least) array of localised surface plasmon resonance island structures on the substrate, each array located to be spaced apart and isolated from each other on the substrate. Each array also has different surface functionalisations for selective interaction with respective analytes. The selective interaction with respective analytes of the first, second, third and fourth surface functionalisations is other than by specific binding of the respective analytes, thereby allowing for cross-reactive sensing by simultaneous analysis of localised surface plasmons at each array of localised surface plasmon resonance island structures. Also disclosed is a method of analysing a fluid to detect the presence and/or concentration of at least one analyte, using such a device.

IPC Classes  ?

• G01N 21/55 - Specular reflectivity
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

Abstract

A heat pump system for controlling the internal temperature of a building. The system comprises a compressor, a first heat exchanger, an expansion device and a second heat exchanger which are fluidly coupled together by a flow of refrigerant to define a refrigerant circuit, and a thermal energy storage means which is thermally couplable to the refrigerant circuit to exchange thermal energy with the refrigerant. The heat pump system is configured to be operable in a normal heating mode and in a defrosting mode. In the normal heating mode, thermal energy is transferred from the second heat exchanger into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building. In the defrosting mode thermal energy is transferred from the thermal energy storage means into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building and by the second heat exchanger to defrost the second heat exchanger. The heat pump system comprises a switching assembly which is configured to switch between the normal heating and defrosting modes, and wherein the switching assembly is configured, when operating the heat pump system in the defrosting mode, to direct refrigerant exiting the first heat exchanger to flow through the second heat exchanger to cause residual heat in the refrigerant to defrost the second heat exchanger.

IPC Classes  ?

• F25B 47/02 - Defrosting cycles

Abstract

A microfluidic device comprises a semi-permeable membrane, a first channel and a second channel. The first and second channels are provided on opposing sides of the membrane and in registration with each other. A first pump provides a flow of a fluid sample along the first channel in a first direction. A second pump provides a flow of a diluent along the second channel in a second direction opposite to the first direction such the diluent flows in reverse direction to the fluid sample. A third channel is provided, with first and second ends, the first end in communication with the first channel to receive the fluid sample therefrom. A plurality of electrodes is provided in the third channel and configured to form a dielectrophoresis capture region in the third channel. An opening is provided at the second end of the third channel, and a metallic surface provided at the second end of the third channel opposite to the opening.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A particulate transport apparatus comprising a reciprocation mechanism having a lower end and an upper end. The reciprocation mechanism comprises a sequence of pockets arranged along a particulate transport path of the reciprocation mechanism. Each pocket is arranged so that, when the reciprocation mechanism is arranged in an upright orientation and caused to reciprocate with a source of particulate at the lower end of the reciprocation mechanism, particulate is thrown from each pocket in the sequence to a respective next pocket in the sequence to effect an overall upright particulate transport path towards the upper end of the reciprocation mechanism.

IPC Classes  ?

• B65G 49/00 - Conveying systems characterised by their application for specified purposes not otherwise provided for
• B65G 35/00 - Mechanical conveyors not otherwise provided for
• B65G 53/40 - Feeding or discharging devices
• B65G 59/02 - De-stacking from the top of the stack
• B65G 27/04 - Load-carriers other than helical or spiral channels or conduits

Abstract

The present disclosure relates to methods for treating tendinopathy, e.g., rotator cuff tendinopathy, using IL-17 antagonists, e.g., secukinumab. Also disclosed herein are uses of IL-17 antagonists. e.g., IL-17 antibodies, such as secukinumab, for treating tendinopathy patients, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

IPC Classes  ?

• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue

Abstract

A vital signs monitoring system configured to estimate the heart rates of two or more subjects using a plurality of subcarriers of a radio frequency (RF) signal.

IPC Classes  ?

• A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves using microwaves or terahertz waves
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Pseudomonas aeruginosa infections. Methods of using S-type pyocin proteins, particularly those comprising an S2, SD2, S5 or AP41 targeting portion or an S2, SD2, S5 or AP41 effector portion are provided.

IPC Classes  ?

• C07K 14/21 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Pseudomonadaceae (F)
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention provides a chemical computer comprising a matrix, an input device and an analytical device. The matrix comprises a plurality of interconnected reaction spaces holding a reaction mixture, and the reaction spaces are interconnected by fluid channels. The input device is for independently addressing each of a plurality of reaction spaces within the matrix, and to independently address one or more fluid channels. The analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provided the use of the chemical computer as such, and methods of computing using the chemical computer, where such methods comprise the step of addressing the reaction spaces, optionally addressing the fluid channels, and analysing a reaction characteristic of a reaction mixture in a reaction space.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G16C 20/00 - Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
• G06N 5/00 - Computing arrangements using knowledge-based models
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention provides a chemical computer comprising a matrix, an input device and an analytical device. The matrix comprises a plurality of interconnected reaction spaces holding a reaction mixture, and the reaction spaces are interconnected by fluid channels. The input device is for independently addressing each of a plurality of reaction spaces within the matrix, and to independently address one or more fluid channels. The analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provided the use of the chemical computer as such, and methods of computing using the chemical computer, where such methods comprise the step of addressing the reaction spaces, optionally addressing the fluid channels, and analysing a reaction characteristic of a reaction mixture in a reaction space.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G16C 20/00 - Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures

Abstract

The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.

IPC Classes  ?

• G01R 1/067 - Measuring probes
• C23F 4/00 - Processes for removing metallic material from surfaces, not provided for in group or
• G01R 3/00 - Apparatus or processes specially adapted for the manufacture of measuring instruments

Abstract

The invention provides a method for the exploration of chemical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product has a superior fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical inputs. Each reaction in the second series differs in one or more chemical and/or physical inputs. The invention also provides an automated exploration apparatus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
• C40B 50/00 - Methods of creating libraries, e.g. combinatorial synthesis
• C40B 60/02 - Integrated apparatus specially adapted for creating libraries, screening libraries and for identifying library members
• C40B 40/18 - Libraries containing only inorganic compounds or inorganic materials

Abstract

The invention provides a method for the exploration of chem¬ ical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product lias a superi¬ or fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical in¬ puts. Each reaction in the second series differs in one or more chemical and/ or physical inputs. The invention also provides an automated exploration ap¬ paratus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• C40B 40/18 - Libraries containing only inorganic compounds or inorganic materials
• C40B 50/00 - Methods of creating libraries, e.g. combinatorial synthesis
• C40B 60/02 - Integrated apparatus specially adapted for creating libraries, screening libraries and for identifying library members
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation

Abstract

A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5μ. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride. The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.

IPC Classes  ?

• H01M 4/02 - Electrodes composed of, or comprising, active material
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

a) with color pixels the value of which is a function of a reflectivity and a speed of the subject; —a processing of the micro-Doppler images (6) for: computing a so-called monochromatic image having monochromatic pixels, each having a given monochromatic intensity, on the basis of the color pixels of each color micro-Doppler image; transforming the monochromatic image into a binary image by segmentation, according to a binary luminous intensity threshold, of the monochromatic pixels, producing binary pixels, the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel, with respect to the threshold.

IPC Classes  ?

• G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G08B 21/04 - Alarms for ensuring the safety of persons responsive to non-activity, e.g. of elderly persons

Abstract

A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

IPC Classes  ?

• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

A surface plasmonic sensing device (10) comprises a substrate (12) and a first array (20) and a second array (22) of localised surface plasmon resonance island structures (20, 22) on the substrate (12). The surface plasmon resonance island structures (20, 22) of the first (20) and second (22) array respectively have first and second surface functionalisation for selective interaction with respective analytes. The first surface functionalisation is different to the second surface functionalisation. The first (20) and second (22) arrays are interspersed with each other to provide a composite array in a main sensing region (14) of the device (10). Also disclosed is a method for manufacturing a surface plasmonic sensing device (10) and a method of analysing a fluid comprising a mixture of two or more analytes. The surface plasmonic sensing device (10) may further comprise a reference region (16) and an auxiliary sensing region (18).

IPC Classes  ?

• G01N 21/552 - Attenuated total reflection

Abstract

An ultrasonic transducer for surgical applications is disclosed. The ultrasonic transducer comprises: a back mass; a front mass; an ultrasonic actuator arrangement held between the back mass and the front mass; and an ultrasonic horn arrangement forward of the front mass. The back mass, ultrasonic actuator arrangement, front mass and ultrasonic horn arrangement are arranged along a longitudinal axis of the transducer. Vibrations generated by the ultrasonic actuator arrangement are conducted into the front mass and into the ultrasonic horn arrangement along a vibrational energy transfer path and are amplitude amplified by the ultrasonic horn arrangement. One or more of the back mass, front mass and ultrasonic horn arrangement includes a plurality of openings opening towards the longitudinal axis and intersecting the vibrational energy transfer path and configured to provide an increased mechanical compliance in a direction along the vibrational energy transfer path.

IPC Classes  ?

• A61B 17/32 - Surgical cutting instruments

Abstract

The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BRCA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A system that provides the ability to integrate both diagnostic tissue detection and therapeutic tissue treatment functionality in an implantable medical device (IMD), such as a graft or stent. The system comprises: an IMD having a pair of electrodes configured to contact biological tissue at an implant location; an impedance sensor configured to detect data indicative of a complex impedance of the biological tissue at the electrodes for a plurality of frequencies; and an analysis device configured to determine one or more cell types in the biological tissue using information indicative of variation in phase and magnitude of the complex impedance across the plurality of frequencies. The system may include a signal generator for applying a treatment signal to the same electrodes.

IPC Classes  ?

• A61B 5/0537 - Measuring body composition by impedance, e.g. tissue hydration or fat content
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
• A61N 1/375 - Constructional arrangements, e.g. casings

Abstract

A readout integrated circuit (IC) architecture for a tunnelling magnetoresistive (TMR) sensor which uses common mode feedback to achieve a performance level suitable for accurate detection of biomagnetic signals. The architecture uses a three-operational amplifier configuration with chopper stabilization. The architecture may form part of a fully integrated biomagnetic sensor electronics package that includes an array of TMR sensors together with modules for signal amplification and conditioning, data conversion and communication.

IPC Classes  ?

• A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 33/00 - Arrangements or instruments for measuring magnetic variables
• G01R 33/09 - Magneto-resistive devices

Abstract

A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 μm.

IPC Classes  ?

• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61M 15/00 - Inhalators
• B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
• H03H 9/145 - Driving means, e.g. electrodes, coils for networks using surface acoustic waves

Abstract

The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

IPC Classes  ?

• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

IPC Classes  ?

• A61K 35/68 - Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

A heat pump system for controlling the internal temperature of a building. The system comprises a compressor, a first heat exchanger, an expansion device and a second heat exchanger which are fluidly coupled together by a flow of refrigerant to define a refrigerant circuit, and a thermal energy storage means which is thermally couplable to the refrigerant circuit to exchange thermal energy with the refrigerant. The heat pump system is configured to be operable in a normal heating mode and in a defrosting mode. In the normal heating mode, thermal energy is transferred from the second heat exchanger into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building. In the defrosting mode thermal energy is transferred from the thermal energy storage means into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building and by the second heat exchanger to defrost the second heat exchanger. The heat pump system comprises a switching assembly which is configured to switch between the normal heating and defrosting modes, and wherein the switching assembly is configured, when operating the heat pump system in the defrosting mode, to direct refrigerant exiting the first heat exchanger to flow through the second heat exchanger to cause residual heat in the refrigerant to defrost the second heat exchanger.

IPC Classes  ?

• F25B 47/02 - Defrosting cycles

Abstract

A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.

IPC Classes  ?

• H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode
• G01J 1/44 - Electric circuits
• G01S 7/4863 - Detector arrays, e.g. charge-transfer gates
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The invention relates to methods of increasing stomatal function in plants, which as a result leads to an increase in carbon assimilation and/or water use efficiency and ultimately an increase in yield. In particular the methods of the invention relate to the expression of light-gated potassium channels in the stomatal complex. Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

IPC Classes  ?

• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Abstract

The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.

IPC Classes  ?

• G01R 1/067 - Measuring probes
• G01R 3/00 - Apparatus or processes specially adapted for the manufacture of measuring instruments
• C23F 4/00 - Processes for removing metallic material from surfaces, not provided for in group or
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

IPC Classes  ?

• A01N 37/46 - N-acyl derivatives

Abstract

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

IPC Classes  ?

• A01N 37/46 - N-acyl derivatives
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• C07K 14/495 - Transforming growth factor [TGF]
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.

IPC Classes  ?

• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Abstract

Provided is a fluid handling device having multiple flow pathways through the device. The device has a fluid directing manifold comprising an array of interconnected multi-directional valves, and a plurality of ports in fluid connection with the array. The device also has a controller to set the position of the multi-directional valves. The manifold is configured to provide at least two independent flow paths between a pair of ports within the manifold. Also provided is a method of using the device, and an automated chemical synthesis platform comprising the device.

IPC Classes  ?

• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Abstract

The present invention provides a method for estimating the molecular complexity of a sample, for example to determine whether biotic or synthetic components are present in the sample. The method comprises the steps of (a) performing one of MS/MS, NMR or IR on a sample; (b) determining the unique peaks in the resulting spectrum; and (c) calculating the molecular assembly index of the sample based on the number of unique peaks in the spectrum.

IPC Classes  ?

• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A surface plasmonic sensing device (10) comprises a substrate (12) and a first array (20) and a second array (22) of localised surface plasmon resonance island structures (20, 22) on the substrate (12). The surface plasmon resonance island structures (20, 22) of the first (20) and second (22) array respectively have first and second surface functionalisation for selective interaction with respective analytes. The first surface functionalisation is different to the second surface functionalisation. The first (20) and second (22) arrays are interspersed with each other to provide a composite array in a main sensing region (14) of the device (10). Also disclosed is a method for manufacturing a surface plasmonic sensing device (10) and a method of analysing a fluid comprising a mixture of two or more analytes. The surface plasmonic sensing device (10) may further comprise a reference region (16) and an auxiliary sensing region (18).

IPC Classes  ?

• G01N 21/552 - Attenuated total reflection
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

A method and a system for generating a hyper-entangled high-dimensional time-bin frequency-bin state, the method comprising generating a hyper-entangled state composed of a time-bin and frequency-bin encoded state, and individually modifying at least one of: i) the amplitude and ii) the phase of the state components at different frequency-bins and different time-bins of the hyper-entangled state. The system comprises a non-linear medium exited with multiple pulses in broad phase-matching conditions, a frequency mode separator and an amplitude/phase modulator, the frequency mode separator temporally and spatially separating frequency modes of the hyper-entangled state, the amplitude/phase modulator individually modifying at least one of: i) the amplitude (and ii) the phase of the state components at different frequency-bins and different time-bins of the hyper-entangled state.

IPC Classes  ?

• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
• G02F 1/365 - Non-linear optics in an optical waveguide structure

Abstract

Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem.

IPC Classes  ?

• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G06J 1/00 - Hybrid computing arrangements

Abstract

The present invention is based on the identification of a network of biomarkers which are characteristic of disease remission in patients with rheumatoid arthritis. The biomarkers provide a sensitive read-out of patient pathological status which allows treatment to be tailored, administered, evaluated and withdrawn in the appropriate clinical circumstances avoiding disease relapse, flare and unnecessary treatment with toxic and costly drugs. Accordingly, the present invention relates to novel diagnostic assays for disease remission in patients with rheumatoid arthritis. The invention also relates to methods, devices and kits for identifying patients in remission, evaluating therapeutic effectiveness in achieving remission and predicting the likelihood of relapse.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease

Abstract

The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

IPC Classes  ?

• C07D 215/48 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• A61K 51/04 - Organic compounds

Abstract

The invention relates to a device (1) for characterising the actimetry of a subject in real time, having a radar (2) transmitting and receiving radar signals and having a software interface for configuring the form of the transmitted signal; means (3) for processing and computing which are connected to the radar (2) and have a classifier (3a) trained using a database, the means (3) for processing and computing being configured to perform, in real time: - acquisition of colour micro-doppler images (6) having a plurality of colour channels (R, V, B), each having micro-doppler signatures (6a) with colour pixels the value of which depends on a reflectivity and a speed of the subject; - processing of the micro-doppler images (6) to compute an image which is referred to as monochromatic and has monochromatic pixels, each having a given monochromatic intensity, from the colour pixels of each colour micro-doppler image; - transformation of the monochromatic image into a binary image through segmentation, according to an intensity threshold, of the monochromatic pixels, producing binary pixels the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel relative to the threshold.

IPC Classes  ?

• G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified

Abstract

A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency-multiplexed reference signal, and feeding the polarization- and frequency-multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.

IPC Classes  ?

• G01B 9/02015 - Interferometers characterised by the beam path configuration
• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties

Abstract

A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency- multiplexed reference signal, and feeding the polarization- and frequency- multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.

IPC Classes  ?

• G01B 9/02017 - Interferometers characterised by the beam path configuration with multiple interactions between the target object and light beams, e.g. beam reflections occurring from different locations

Abstract

The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.

IPC Classes  ?

• H01M 4/02 - Electrodes composed of, or comprising, active material
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

An imaging apparatus configured to obtain a temporally resolvable signal from an entire scene to be imaged. Instead of scanning the scene to build a three-dimensional image, the imaging apparatus maps the temporally resolvable signal from the entire scene to three-dimensional image data using a mapping model, which may comprise a machine learning algorithm. The temporally resolvable signal can be a reflected signal emitted from the scene in response to a measurement signal pulse emitted by the imaging apparatus. The machine learning algorithm may be trained using a training set comprising temporally resolvable signals associated with corresponding three-dimensional images. The measurement signal pulse may be an acoustic signal (e.g. ultrasound), or may comprise visible light, or radiation in the super high frequency (SHF) or extremely high frequency (EHF) ranges.

IPC Classes  ?

• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
• G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
• G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
• G06N 3/02 - Neural networks

Abstract

A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G02F 1/35 - Non-linear optics
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/067 - Fibre lasers
• H01S 3/13 - Stabilisation of laser output parameters, e.g. frequency or amplitude
• H01S 3/136 - Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling devices placed within the cavity

Abstract

The invention relates to methods of increasing stomatal function in plants, which as a result leads to an increase in carbon assimilation and/or water use efficiency and ultimately an increase in yield. In particular the methods of the invention relate to the expression of light-gated potassium channels in the stomatal complex. Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

IPC Classes  ?

• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

IPC Classes  ?

• G01N 21/80 - Indicating pH value
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The invention relates to CAP2b analogues having activity against hemipteran insects such as aphids, and their use as insect control agents (e.g. insecticides) and plant protection agents. In particular it has been found that a known CAP2b analogue designated 1895, and new CAP2b analogues including molecules designated 2129, 2315, 2316 and 2320, have activity against hemipteran insects and so find use for control of hemipteran insects and plant protection.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A01N 37/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A01M 1/20 - Poisoning, narcotising, or burning insects

Abstract

The invention relates to CAP2b analogues having activity against hemipteran insects such as aphids, and their use as insect control agents (e.g. insecticides) and plant protection agents. In particular it has been found that a known CAP2b analogue designated 1895, and new CAP2b analogues including molecules designated 2129, 2315, 2316 and 2320, have activity against hemipteran insects and so find use for control of hemipteran insects and plant protection.

IPC Classes  ?

• A01M 1/20 - Poisoning, narcotising, or burning insects
• A01N 37/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

44 2-288 2-44 2-) in the reaction space; and an ultrasonicator for providing an ultrasonic field at the working electrode.

IPC Classes  ?

• C25B 1/28 - Per-compounds
• C25B 9/06 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
• C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods

Abstract

A method of fabricating a field-effect transistor in which a native oxide layer is removed prior to etching a gate recess. The cleaning step ensures that the etch of the gate recess starts at the same time across an entire sample, such that a uniform gate recess depth and profile can be achieved across an array of field-effect transistors. This results in a highly uniform switch-off voltage for the field-effect transistors in the array.

IPC Classes  ?

• H01L 27/146 - Imager structures
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 31/0304 - Inorganic materials including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 31/103 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier being of the PN homojunction type

Abstract

Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• A61K 35/68 - Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts

Abstract

The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject, comprising determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining a gene expression profile for DExH-box helicase 9 (DHX9) in the same or another biological sample obtained from the subject, and determining a pre-surgical prognostic risk score for the subject based on the gene expression profile for PDE4D7 and the gene expression profile for DHX9. This may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendations on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

IPC Classes  ?

• G06N 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

IPC Classes  ?

• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.

IPC Classes  ?

• H01L 31/107 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier working in avalanche mode, e.g. avalanche photodiode

Abstract

Provided are novel naphthalene diimide (NDI) compound of Formula 1. The compounds may exhibit colour change from substantially transparent to substantially black upon electrochemical or photochemical stimulus and may be useful in smart windows.

IPC Classes  ?

• C07D 471/06 - Peri-condensed systems
• C09K 9/00 - Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy