Abrégé

PlasmodiumPlasmodium infection. The compound of formula (I) is a compound of general formula: where -R1 is a thiol-reactive group and -L-, -X- and -Y are as described in further detail in the description.

Classes IPC  ?

• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61P 33/06 - Antipaludéens
• C07D 471/04 - Systèmes condensés en ortho

Abrégé

A signal generator is provided that is configured to generate a signal adapted to be delivered to the brain of a subject to alleviate nausea in the subject. The stimulation signal is defined by a waveform having a frequency and a phase. The stimulation signal is characterized by one or more instantaneous disruptions of the phase of the waveform. A system (100) for alleviating nausea is provided. The system (100) comprises: the signal generator (102) configured to generate the stimulation signal; and one or more electrodes (104, 106a-c) configured to deliver the stimulation signal to the brain of a subject.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/04 - Électrodes

Abrégé

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires

Abrégé

The present invention relates to a method of optimising an instruction set for a chemical synthesis and a chemical synthesiser for use in a method of optimising an instruction set for a chemical synthesis. The method comprises (i) performing a chemical synthesis in a reaction vessel of a chemical synthesiser operating according to an instruction set to produce a reaction product, (ii) recording reaction data using an analytical unit of the synthesiser during the chemical synthesis and/or recording product data on the reaction product, (iii) analysing the reaction data and/or product data using a control unit of the chemical synthesiser to determine a characteristic of the synthesis; and (iv) adjusting one or more reaction parameters of the instruction set, to provide an adjusted instruction set, based on a prediction that the adjustment will improve the characteristic of the synthesis.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés

Abrégé

The invention provides a method for the exploration of chemical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product has a superior fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical inputs. Each reaction in the second series differs in one or more chemical and/or physical inputs. The invention also provides an automated exploration apparatus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

Classes IPC  ?

• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
• C40B 40/00 - Bibliothèques en soi, p. ex. matrices, mélanges
• C40B 50/00 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire
• C40B 60/02 - Appareils intégrés spécialement adaptés à la création, au criblage de bibliothèques et à l'identification des éléments des bibliothèques

Abrégé

A method for the dielectrophoretic assembly of nanowires onto a substrate, including the steps: (i) providing a suspension of nanowires in a carrier liquid; (ii) providing a substrate; (iii) providing an array of electrodes on an electrode array support; (iv) bringing the substrate into proximity with the electrode array support at a first surface of the substrate; (v) locating at least a second surface of the substrate, opposite to the first surface, in the suspension of nanowires; and (vi) applying a voltage signal to the array of electrodes. Accordingly, there is generated, through the substrate, a corresponding electric field in the suspension of nanowires and a dielectrophoretic force on the nanowires in the suspension of nanowires. This causes dielectrophoretic assembly of nanowires onto the second surface of the substrate in an arrangement corresponding to the array of electrodes.

Classes IPC  ?

• B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• H10K 85/00 - Matériaux organiques utilisés dans le corps ou les électrodes des dispositifs couverts par la présente sous-classe
• B03C 5/00 - Séparation de particules des liquides dans lesquels elles sont dispersées, par effet électrostatique
• B03C 5/02 - Séparateurs
• H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
• H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices

Abrégé

The invention relates to the field of medicine, in particular of cardiology. The present invention is based on the identification of Runx 1 as a therapeutic target in heart failure with preserved ejection fraction (HFpEF)and addresses the pressing need for HFpEF therapies. Accordingly, the present invention relates to novel methods for the prophylaxis and treatment of HFpEF, and particularly, although not exclusively, to Runxf inhibitors for use in the prophylaxis and treatment of HFpEF. The invention provides methods of prophylaxis or treatment of HFpEF and compounds and compositions for use in those methods.

Classes IPC  ?

• A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
• A61K 31/5513 - 1,4-Benzodiazépines, p. ex. diazépam
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque

Abrégé

The present invention relates to a gel composition comprising: (a) a supramolecular gel formed from or comprising a network of one or more low molecular weight gelators (LMWGs) in an aqueous solution; wherein the supramolecular gel: (i) has a storage modulus (G') of from 100 to 1,000,000 Pa; (ii) has a loss modulus (G'') such that G''/G' is from 0.01 to 0.5; and (iii) has a breakage strain of from 0.1 to 300%. Additionally, the invention relates to processes for preparing such gel compositions. The present invention also relates to a gel composition comprising an encapsulated component, processes for preparing such gel compositions and processes relating to storing, transporting and extracting such encapsulated components.

Classes IPC  ?

• C08G 83/00 - Composés macromoléculaires non prévus dans les groupes
• C08L 101/14 - Compositions contenant des composés macromoléculaires non spécifiés caractérisées par des propriétés physiques, p. ex. anisotropie, viscosité ou conductivité électrique les composés macromoléculaires étant solubles dans l'eau ou gonflables dans l'eau, p. ex. gels aqueux
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• C08J 3/075 - Gels macromoléculaires

Abrégé

A computer-implemented method for upscaling the resolution of an image which uses a co-registered pair of images comprises a first image having a first resolution and a second image having a second resolution that is lower than the first resolution. The method determines local or global relationships between the images, and generates an upscaled version of the second image (a super-resolved image) using the local or global relationships and the pixel data of the first image. Embodiments of the invention may be applied to any imaging modalities, for example the first image and the second image may be derived from two different imaging modalities (e.g., images based on different wavelengths). For example, the first image may comprise a high-resolution intensity image and the second image may comprise a lower-resolution fluorescence lifetime imaging microscopy image.

Classes IPC  ?

• G06T 3/4053 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement basé sur la super-résolution, c.-à-d. où la résolution de l’image obtenue est plus élevée que la résolution du capteur

Abrégé

An antenna system comprising: a receiving antenna section configured to receive a wireless radio frequency signal; and a rectifier system connected to the receiving antenna section by a primary transmission line that is configured to convey the radio frequency signal received by the receiving antenna section. The rectifier system is configured to convert the received radio frequency signal into a direct current power signal. The antenna system further comprises: a processing unit configured to be powered by the direct current power signal from the rectifier system; and a coupler configured to capacitively couple a portion of the radio frequency signal conveyed by the primary transmission line for processing by the processing unit without passing through the rectifier system.

Classes IPC  ?

• H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
• H01Q 1/24 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets avec appareil récepteur
• H02J 50/20 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant des micro-ondes ou des ondes radio fréquence
• H02J 50/27 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant des micro-ondes ou des ondes radio fréquence caractérisés par le type d'antennes de réception, p. ex. les antennes redresseuses

Abrégé

Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Classes IPC  ?

• A61K 35/68 - Protozoaires, p. ex. flagelles, amibes, sporozoaires, plasmodium ou toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs
• C12N 15/79 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes

Abrégé

The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

Classes IPC  ?

• C07D 215/48 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
• A61K 51/04 - Composés organiques

Abrégé

A neural microprobe is disclosed. The neural microprobe comprises a stacked structure having a base layer, a core layer, a metal layer, and a ceiling layer. The base layer is formed from a first species of biocompatible polymer. The core layer is formed from a second species of biocompatible polymer deposited on the base layer. The metal layer is deposited on the core layer. The ceiling layer is formed from the first species of biocompatible polymer deposited on the metal layer and comprises a plurality of trenches etched through the ceiling layer to expose portions of the metal layer, said exposed portions defining electrodes of an electrode array of the neural microprobe. The first species of biocompatible polymer has a lower coefficient of thermal expansion than the second species. A method of manufacturing a neural microprobe comprises providing a first mask on the ceiling layer, wherein the first mask is lithographically patterned to define a plurality of gaps in the first mask; providing a second mask on the first mask; etching, with a first etchant, through the second mask and the gaps in the first mask, trenches in the ceiling layer to expose the portions of the metal layer defining the electrodes of the electrode array; and etching, with a second etchant, the stacked structure to remove any remaining portions of the first and second masks, and to release a base layer of the stacked structure from the release layer.

Classes IPC  ?

• A61B 5/24 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau

Abrégé

A bioelectronics system is provided. The bioelectronics system comprises an implant device having multiple pairs of electrodes integrated therein and an implantable control electronics module. The implantable control electronics module comprises: a multiplexer configured to enable a separate signal to be independently applied across each pair of electrodes, a microcontroller, and a wireless communication module. The implantable control electronics module further comprises either: (i) an impedance analyser configured to measure a respective complex impedance across each pair of electrodes, wherein the microcontroller is configured to encode the measured complex impedances as complex impedance information, and the wireless communication module is configured to transmit the complex impedance information to a remote unit for analysis; or (ii) a waveform generator configured to apply respectively determined waveform profiles across each pair of electrodes, wherein the microcontroller is configured to determine the respective waveform profiles to be applied across each pair of electrodes based on instructions received, from a remote unit and by the wireless communication module, to deliver an electrical signal across the multiple pairs of electrodes.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/0537 - Mesure de la composition du corps par impédance, p. ex. de l’hydratation des tissus ou de la teneur en graisses
• A61B 5/0538 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps invasive, p. ex. en utilisant un cathéter
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers

Abrégé

The invention relates to an apparatus and methods for performing air-sensitive and/or water-sensitive reactions autonomously, for example with an automated chemical synthesiser. The automated chemical synthesiser comprises a first reactionware in fluid communication with a reagent manifold, a vacuum line and a gas line, wherein the synthesiser further comprises a control unit for automatically and independently controlling fluid communication of the reactionware with the reagent manifold, vacuum line and gas line, and the gas line is for the supply of anaerobic and/or anhydrous gas. The synthesiser is operable to provide an anaerobic and/or anhydrous environment, such as atmosphere, within a reactionware, such that chemical syntheses which are sensitive to oxygen and/or water may be performed in the reactionware.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• B01J 3/00 - Procédés utilisant une pression supérieure ou inférieure à la pression atmosphérique pour obtenir des modifications chimiques ou physiques de la matièreAppareils à cet effet
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01J 4/00 - Dispositifs d'alimentationDispositifs de commande d'alimentation ou d'évacuation
• B01J 19/24 - Réacteurs fixes sans élément interne mobile

Abrégé

A coil array for use with a magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is disclosed. The coil array comprises no more than eight transmitter coils arranged around a central axis of the coil array in first and second circumferential rows that are respectively positioned proximal to the head and neck of a patient when in use and are displaced longitudinally along the central axis with respect to each other. A coil assembly for use with a magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is also disclosed. The coil assembly comprises the disclosed coil array and a receiver coil array. A magnetic resonance imaging apparatus that is operable with a permanent magnetic field of 7 T is disclosed. Said apparatus comprises the disclosed coil assembly.

Classes IPC  ?

• G01R 33/34 - Détails de structure, p. ex. résonateurs

Abrégé

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

Classes IPC  ?

• A01N 37/46 - Dérivés N-acylés
• A01N 47/44 - GuanidineSes dérivés
• A01P 7/04 - Insecticides
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BR-CA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.

Classes IPC  ?

• C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture

Abrégé

Described herein are molecules and compounds for use in medicine, as medicaments and for the treatment or prevention of cardiac diseases.

Classes IPC  ?

• A61K 38/46 - Hydrolases (3)
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides

Abrégé

The invention relates to protein bacteriocins (PBs) as therapeutic agents, and specifically to protein complexes comprising two or more PB molecules associated with a protein scaffold which comprises cognate immunity protein domains for the effector portions of the respective PBs. In particular, the invention provides an anti-bacterial protein complex comprising (a) a first PB molecule and a second PB molecule; and (b) an immunity protein scaffold comprising a first immunity protein domain and a second immunity protein domain; wherein the first and second immunity protein domains are non-covalently bound to the respective first and second PB molecules.

Classes IPC  ?

• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• C07K 14/21 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
• C07K 14/24 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant d'Entérobacteriaceae (F), p. ex. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
• C07K 14/245 - Escherichia (G)
• C07K 14/255 - Salmonella (G)
• C07K 14/26 - Klebsiella (G)
• C07K 14/265 - Enterobacter (G)
• C12N 9/22 - Ribonucléases
• C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• A61K 38/46 - Hydrolases (3)
• A61P 31/04 - Agents antibactériens

Abrégé

There is disclosed an apparatus (100) and method for determining a fluorescence lifetime of a sample (102), the apparatus comprising an interferometer (106). The method comprises interfering, by a beam splitter (110) of the interferometer (106), a fluorescence signal from a sample (102) received along a first arm (108a) of the interferometer with a reference pulse (118) received along a second arm (108b) of the interferometer (106). The reference pulse (118) has a frequency selected to interfere with the fluorescence signal. The method further comprises outputting, by a first photon detector (134a) that receives a first combined signal output from the beam splitter (110), a first detection signal indicative of the number of photons in the first combined signal; outputting, by a second photon detector (134b) that receives a second combined signal output from the beam splitter (110), a second detection signal indicative of the number of photons in the second combined signal; and determining the fluorescence lifetime of the sample (102) based on a correlation between the first and second detection signals over a range of relative path delays between the first and second arms (108a,108b) of the interferometer (106).

Classes IPC  ?

• G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

There is provided a method and a system for determining an activity being performed by a person and/or monitoring occupancy in an environment. The environment comprises a plurality of passive RFID tags. The method comprises: receiving, over a sample period, in response to an interrogation signal, one or more response signals from one or more of the passive RFID tags; determining, for each passive RFID tag, a normalised count value based on a number of response signals received from said passive RFID tag over the sample period; and using a machine learning algorithm to determine the activity being performed in the environment and/or monitor occupancy of the environment. The machine learning algorithm is configured to take the normalised count values as inputs, and determine, based on the normalised count values, the activity or occupancy during the sample period.

Classes IPC  ?

• G06Q 10/02 - Réservations, p. ex. pour billetterie, services ou manifestations
• G06Q 10/10 - BureautiqueGestion du temps
• G06Q 50/40 - Procédés d’affaires s’appliquant à l’industrie du transport
• G06K 17/00 - Méthodes ou dispositions pour faire travailler en coopération des équipements couverts par plusieurs des groupes principaux , p. ex. fichiers automatiques de cartes incluant les opérations de transport et de lecture

Abrégé

The invention relates to polypeptides, in particular polypeptides comprising a diyne linkage. The invention provides a polypeptide of Formula (I), a polypeptide and amino acids for the preparation of the diyne linked polypeptides, and methods for the preparation of the diyne linked polypeptides. The invention also provides medical uses of the polypeptides.

Classes IPC  ?

• A61K 38/12 - Peptides cycliques
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The invention relates in general to the field of CAR-T cells. The invention in particular relates to improved methods for obtaining CAR-T cells, and improved CAR-T cells, as well as uses thereof. The method in further relates to activating or expressing a phosphodiesterase (PDE) in T-cells during CAR-T cell generation.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• C07K 14/725 - Récepteurs de lymphocytes-T
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK

Abrégé

MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• C12N 15/86 - Vecteurs viraux

Abrégé

A granular material conveyance apparatus [100] comprises a discharge conduit [102] comprising a proximal end [102a] configured to receive granular material from a granular material source and a distal end [102b] separated from the proximal end [102a] along a longitudinal direction of the conduit [102]. The discharge conduit [102] is movable with respect to the granular material source. An end effector [110] is engaged externally with respect to the discharge conduit [102] so as to be translatable along the longitudinal direction of the discharge conduit [102]. The discharge conduit [102] further comprises a conveyor [106] configured to move the granular material along a conveyance path [108] disposed within the discharge conduit [102] from the proximal end [102a] towards the distal end [102b] of the discharge conduit [102]. The end effector [110] has an inlet [112] in communication with the conveyance path [108] at least at a plurality of positions of the end effector [110] with respect to the discharge conduit [102] to allow the granular material to be conveyed from the discharge conduit [102] and into the end effector [110]. Also disclosed is a method and apparatus for transferring granular material between a filling module [202] and a receiving module [204].

Classes IPC  ?

• B65G 33/22 - Transporteurs rotatifs à vis ou à hélice pour matériaux solides fluents comportant une vis ou plusieurs vis enfermées dans un carter tubulaire avec moyens pour retarder l'écoulement du matériau à l'extrémité de décharge du carter
• B65G 33/14 - Transporteurs rotatifs à vis ou à hélice pour matériaux solides fluents comportant une vis ou plusieurs vis enfermées dans un carter tubulaire
• B65G 33/24 - Transporteurs rotatifs à vis ou à hélice Détails

Abrégé

The present invention concerns a structurally distinct immunosuppressive mimic of TGF-β that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-β mimic which fully replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.

Classes IPC  ?

• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• C07K 14/495 - Facteur de croissance transformant [TGF]
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK

Abrégé

The invention relates to a product for use in the treatment, prevention or amelioration of prostate cancer in a subject in need thereof, wherein the product induces the expression of PDE4D7 or promotes activity of phosphodiesterase 4D7. The product may be a direct or indirect activator of PDE4D7 activity or a product for expressing or promoting expression of PDE4D7 in a subject. The invention further defines a kit of parts and an in vitro or ex vivo use of the product.

Classes IPC  ?

• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 35/00 - Agents anticancéreux
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

nrr , nii Qrr , Qii i ) and normalized three-dimensional magnetization vector (I) are accurately obtained.

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation

Abrégé

A biomagnetic sensor that incorporates an integrated active noise cancellation unit that uses a gradiometer to remove ambient magnetic noise from a detection signal obtained from a tunnelling magnetoresistive (TMR) sensor unit that is indicative of a magnetic field adjacent to biological tissue. The ambient magnetic noise can thus be removed in real time at a front end of the sensor (e.g. as part of circuity in the sensor body itself). The active noise cancellation technique proposed herein may be effective enough to enable the biomagnetic sensor to be used in an unshielded environment (i.e. an environment that is subject to the Earth's magnetic field, for example), which widens significantly the potential uses for the sensor.

Classes IPC  ?

• A61B 5/242 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques
• A61B 5/248 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques spécialement adaptée aux signaux magnétoneurographiques [MNG], p. ex. aux signaux magnétospinographiques [MSG]
• A61B 5/305 - Réjection de mode commun
• A61B 5/30 - Circuits d’entrée à cet effet
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The invention relates to a method and apparatus for performing and characterising a chemical synthesis, such as those performed with an automated chemical synthesis platform, including such that are portable platforms, the method comprising the steps of: performing a chemical synthesis in a chemical synthesiser; recording analytical data during the chemical synthesis, and developing a profile for the analytical data recorded over time; and comparing the profile for the chemical synthesis against a reference profile, which reference profile is the analytical data recorded over time for a reference chemical synthesis, wherein the chemical synthesis and the reference chemical synthesis share at least the same reagents and method steps for the same intended product, such as the chemical synthesis and the reference chemical synthesis sharing the same instruction set. The method and apparatus are for intended for use in replication of approved, chemical syntheses based on common reaction platforms.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques

Produits et services

Software; Internet of Things [IoT] sensors; Internet of Things [IoT] gateways; computer hardware modules for use with the Internet of Things [IoT]; computer application software for use in implementing the Internet of Things [IoT]; development kits; software development kits; sensors; imaging apparatus. Business advisory services; business project management. Education; training. Software as a Service [SaaS]; product development; product development consultation; research and development services; scientific and technological consulting; engineering services; design and development of prototypes; technical research in the field of computer vision; laboratory testing services; engineering testing services; design of integrated circuits; design of electric circuit boards.

Abrégé

The disclosed invention relates to a method for identifying biomarkers for the stratification of hypertensive patients among different hypertension diseases: endocrine forms of hypertension and primary hypertension. The method is a machine-learning based method using one trained classifier on a predefined input dataset to rank several combinations of omics biomarkers (miRNA, steroids, metanephrines, small metabolites) on the basis of the computation of at least one evaluation parameter. A combination of biomarkers is selected to stratify the hypertensive patient among said plurality of hypertension diseases. Also, the disclosed invention relates to a method for stratifying hypertensive patients, such as hypertensive patients with endocrine forms of hypertension (EHT). The method comprises operating a trained classifier on a combination of biomarkers determined from the hypertensive patient to stratify the hypertensive patient among several types of hypertensive patients such as endocrine forms of hypertension and primary hypertension.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

Plants modified to exhibit reduced plasticity and related methods and compositions are disclosed. The plants have reduced developmental plasticity in response to changes in light and temperature conditions, and exhibit additional features such as earlier, more consistent and uniform flowering regardless of changes in day length and temperature, and reduced listing in the field.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 15/29 - Gènes codant pour des protéines végétales, p. ex. thaumatine
• C12N 5/04 - Cellules ou tissus végétaux
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• A01H 1/00 - Procédés de modification des génotypes
• A01H 3/00 - Procédés de modification des phénotypes
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 9/22 - Ribonucléases

Abrégé

The invention relates to the treatment of chronic myeloid leukemia (CML). In particular it relates to the treatment of CML with inhibitors of mitochondrial pyruvate transport, which are able to target leukemic stem cells (LSCs) which are resistant to therapy with tyrosine kinase inhibitors (TKIs). Combination therapies with BCR-ABL kinase inhibitors are also described.

Classes IPC  ?

• A61K 31/26 - Esters d'acide cyanique ou isocyaniqueEsters d'acide thiocyanique ou isothiocyanique
• A61K 31/27 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carbamiques ou thiocarbamiques, p. ex. méprobamate, carbachol, néostigmine
• A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides methods for reducing a nitro compound using a mediator, such as a polyoxometalate. A method of the invention comprises oxidising a reduced mediator to yield a mediator, and reducing a nitro compound as a first step; whilst reducing the mediator to yield a reduced mediator as a second step, which reduced mediator is subsequently used in the first step.

Classes IPC  ?

• C25B 3/09 - Composés contenant au moins un atome d’azote
• C25B 3/25 - Réduction

Classes IPC  ?

• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
• G16C 20/80 - Visualisation de données
• G16C 20/90 - Langages de programmationArchitectures informatiquesSystèmes de bases de donnéesStockage de données

Abrégé

The invention relates to a method for generating a database for chemical syntheses and a method for performing a chemical synthesis using a database. The method for generating a database comprises generating a series of instruction sets for a series of chemical syntheses from the literature, wherein each instruction set is a machine readable and executable universal language for a chemical synthesiser; assembling the series of instructions sets within a database, and making the instruction sets available for access and autonomous execution by a chemical synthesiser. The method for performing a chemical synthesis comprises accessing an instruction set from a database, providing the instruction set to a chemical synthesiser, and autonomously executing the instruction set on the chemical synthesiser thereby to perform the chemical synthesis. The invention makes use of a standardised and step-focussed syntax to describe the chemical syntheses, and a universal synthesis automation platform.

Classes IPC  ?

• G16C 20/80 - Visualisation de données
• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
• G16C 20/90 - Langages de programmationArchitectures informatiquesSystèmes de bases de donnéesStockage de données

Abrégé

The present invention relates to solute carrier proteins as targets for cancer therapy. In particular, it relates to the inhibition of serine transport by two or more solute carrier proteins. The compositions, uses and methods of the present invention have utility in the treatment of cancer.

Classes IPC  ?

• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
• A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 35/00 - Agents anticancéreux

Classes IPC  ?

• G01N 21/55 - Réflexion spéculaire
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé

Abrégé

A localised surface plasmonic sensing device is disclosed. This comprises: a substrate; a first, second, third and fourth (at least) array of localised surface plasmon resonance island structures on the substrate, each array located to be spaced apart and isolated from each other on the substrate. Each array also has different surface functionalisations for selective interaction with respective analytes. The selective interaction with respective analytes of the first, second, third and fourth surface functionalisations is other than by specific binding of the respective analytes, thereby allowing for cross-reactive sensing by simultaneous analysis of localised surface plasmons at each array of localised surface plasmon resonance island structures. Also disclosed is a method of analysing a fluid to detect the presence and/or concentration of at least one analyte, using such a device.

Classes IPC  ?

• G01N 21/55 - Réflexion spéculaire
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé

Abrégé

A heat pump system for controlling the internal temperature of a building. The system comprises a compressor, a first heat exchanger, an expansion device and a second heat exchanger which are fluidly coupled together by a flow of refrigerant to define a refrigerant circuit, and a thermal energy storage means which is thermally couplable to the refrigerant circuit to exchange thermal energy with the refrigerant. The heat pump system is configured to be operable in a normal heating mode and in a defrosting mode. In the normal heating mode, thermal energy is transferred from the second heat exchanger into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building. In the defrosting mode thermal energy is transferred from the thermal energy storage means into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building and by the second heat exchanger to defrost the second heat exchanger. The heat pump system comprises a switching assembly which is configured to switch between the normal heating and defrosting modes, and wherein the switching assembly is configured, when operating the heat pump system in the defrosting mode, to direct refrigerant exiting the first heat exchanger to flow through the second heat exchanger to cause residual heat in the refrigerant to defrost the second heat exchanger.

Classes IPC  ?

• F25B 47/02 - Cycles de dégivrage

Abrégé

A microfluidic device comprises a semi-permeable membrane, a first channel and a second channel. The first and second channels are provided on opposing sides of the membrane and in registration with each other. A first pump provides a flow of a fluid sample along the first channel in a first direction. A second pump provides a flow of a diluent along the second channel in a second direction opposite to the first direction such the diluent flows in reverse direction to the fluid sample. A third channel is provided, with first and second ends, the first end in communication with the first channel to receive the fluid sample therefrom. A plurality of electrodes is provided in the third channel and configured to form a dielectrophoresis capture region in the third channel. An opening is provided at the second end of the third channel, and a metallic surface provided at the second end of the third channel opposite to the opening.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A particulate transport apparatus comprising a reciprocation mechanism having a lower end and an upper end. The reciprocation mechanism comprises a sequence of pockets arranged along a particulate transport path of the reciprocation mechanism. Each pocket is arranged so that, when the reciprocation mechanism is arranged in an upright orientation and caused to reciprocate with a source of particulate at the lower end of the reciprocation mechanism, particulate is thrown from each pocket in the sequence to a respective next pocket in the sequence to effect an overall upright particulate transport path towards the upper end of the reciprocation mechanism.

Classes IPC  ?

• B65G 49/00 - Systèmes transporteurs caractérisés par leur utilisation à des fins particulières, non prévus ailleurs
• B65G 35/00 - Transporteurs mécaniques non prévus ailleurs
• B65G 53/40 - Dispositifs d'alimentation ou de décharge
• B65G 59/02 - Désempilage par le haut de la pile
• B65G 27/04 - Porte-charges autres que les canaux ou conduits hélicoïdaux ou en spirale

Abrégé

The present disclosure relates to methods for treating tendinopathy, e.g., rotator cuff tendinopathy, using IL-17 antagonists, e.g., secukinumab. Also disclosed herein are uses of IL-17 antagonists. e.g., IL-17 antibodies, such as secukinumab, for treating tendinopathy patients, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

Classes IPC  ?

• C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
• A61P 19/04 - Médicaments pour le traitement des troubles du squelette des troubles non-spécifiques du tissu conjonctif

Abrégé

A vital signs monitoring system configured to estimate the heart rates of two or more subjects using a plurality of subcarriers of a radio frequency (RF) signal.

Classes IPC  ?

• A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

Pseudomonas aeruginosa infections. Methods of using S-type pyocin proteins, particularly those comprising an S2, SD2, S5 or AP41 targeting portion or an S2, SD2, S5 or AP41 effector portion are provided.

Classes IPC  ?

• C07K 14/21 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Pseudomonadaceae (F)
• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

The present invention provides a chemical computer comprising a matrix, an input device and an analytical device. The matrix comprises a plurality of interconnected reaction spaces holding a reaction mixture, and the reaction spaces are interconnected by fluid channels. The input device is for independently addressing each of a plurality of reaction spaces within the matrix, and to independently address one or more fluid channels. The analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provided the use of the chemical computer as such, and methods of computing using the chemical computer, where such methods comprise the step of addressing the reaction spaces, optionally addressing the fluid channels, and analysing a reaction characteristic of a reaction mixture in a reaction space.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• G16C 20/00 - Chémo-informatique, c.-à-d. TIC spécialement adaptées au maniement des données physicochimiques ou structurelles des particules, des éléments, des composés ou des mélanges chimiques
• G06N 5/00 - Agencements informatiques utilisant des modèles fondés sur la connaissance
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

The present invention provides a chemical computer comprising a matrix, an input device and an analytical device. The matrix comprises a plurality of interconnected reaction spaces holding a reaction mixture, and the reaction spaces are interconnected by fluid channels. The input device is for independently addressing each of a plurality of reaction spaces within the matrix, and to independently address one or more fluid channels. The analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provided the use of the chemical computer as such, and methods of computing using the chemical computer, where such methods comprise the step of addressing the reaction spaces, optionally addressing the fluid channels, and analysing a reaction characteristic of a reaction mixture in a reaction space.

Classes IPC  ?

• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]
• G16C 20/00 - Chémo-informatique, c.-à-d. TIC spécialement adaptées au maniement des données physicochimiques ou structurelles des particules, des éléments, des composés ou des mélanges chimiques

Abrégé

The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.

Classes IPC  ?

• G01R 1/067 - Sondes de mesure
• C23F 4/00 - Procédés pour enlever des matériaux métalliques des surfaces, non couverts par le groupe ou
• G01R 3/00 - Appareils ou procédés spécialement adaptés à la fabrication des appareils de mesure

Abrégé

The invention provides a method for the exploration of chemical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product has a superior fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical inputs. Each reaction in the second series differs in one or more chemical and/or physical inputs. The invention also provides an automated exploration apparatus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
• G16C 60/00 - Science informatique des matériaux, c.-à-d. TIC spécialement adaptées à la recherche des propriétés physiques ou chimiques de matériaux ou de phénomènes associés à leur conception, synthèse, traitement, caractérisation ou utilisation
• C40B 50/00 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire
• C40B 60/02 - Appareils intégrés spécialement adaptés à la création, au criblage de bibliothèques et à l'identification des éléments des bibliothèques
• C40B 40/18 - Bibliothèques comprenant uniquement des composés inorganiques ou des matériaux inorganiques

Abrégé

The invention provides a method for the exploration of chem¬ ical space through a multigenerational series of synthetic stages. In a first stage, a series of reactions is performed. The products of the first series are analysed, and a first product from the series of reactions is selected. The first product is used as a chemical input for each of the reactions in a second series of reactions. The products of the second series are analysed. The first and second stages are performed autonomously. The selection of a product in the first stage comprises the comparison of the products from the first series of reactions against a fitness function, where the selected product lias a superi¬ or fitness compared with one or more other products in the first series. Each reaction in the first series differs in one or more chemical and/or physical in¬ puts. Each reaction in the second series differs in one or more chemical and/ or physical inputs. The invention also provides an automated exploration ap¬ paratus for performing the method, and the apparatus comprises a controller, and a chemical synthesiser and an analytical unit which are operable by the controller, as described herein.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• C40B 40/18 - Bibliothèques comprenant uniquement des composés inorganiques ou des matériaux inorganiques
• C40B 50/00 - Procédés de création de bibliothèques, p. ex. synthèse combinatoire
• C40B 60/02 - Appareils intégrés spécialement adaptés à la création, au criblage de bibliothèques et à l'identification des éléments des bibliothèques
• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
• G16C 60/00 - Science informatique des matériaux, c.-à-d. TIC spécialement adaptées à la recherche des propriétés physiques ou chimiques de matériaux ou de phénomènes associés à leur conception, synthèse, traitement, caractérisation ou utilisation

Abrégé

a) with color pixels the value of which is a function of a reflectivity and a speed of the subject; —a processing of the micro-Doppler images (6) for: computing a so-called monochromatic image having monochromatic pixels, each having a given monochromatic intensity, on the basis of the color pixels of each color micro-Doppler image; transforming the monochromatic image into a binary image by segmentation, according to a binary luminous intensity threshold, of the monochromatic pixels, producing binary pixels, the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel, with respect to the threshold.

Classes IPC  ?

• G01S 13/89 - Radar ou systèmes analogues, spécialement adaptés pour des applications spécifiques pour la cartographie ou la représentation
• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G08B 21/04 - Alarmes pour assurer la sécurité des personnes réagissant à la non-activité, p. ex. de personnes âgées

Abrégé

A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5μ. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride. The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.

Classes IPC  ?

• H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

Classes IPC  ?

• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Classes IPC  ?

• G01N 21/76 - ChimioluminescenceBioluminescence
• G01N 21/84 - Systèmes spécialement adaptés à des applications particulières
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS

Abrégé

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

A surface plasmonic sensing device (10) comprises a substrate (12) and a first array (20) and a second array (22) of localised surface plasmon resonance island structures (20, 22) on the substrate (12). The surface plasmon resonance island structures (20, 22) of the first (20) and second (22) array respectively have first and second surface functionalisation for selective interaction with respective analytes. The first surface functionalisation is different to the second surface functionalisation. The first (20) and second (22) arrays are interspersed with each other to provide a composite array in a main sensing region (14) of the device (10). Also disclosed is a method for manufacturing a surface plasmonic sensing device (10) and a method of analysing a fluid comprising a mixture of two or more analytes. The surface plasmonic sensing device (10) may further comprise a reference region (16) and an auxiliary sensing region (18).

Classes IPC  ?

• G01N 21/552 - Réflexion totale atténuée

Abrégé

An ultrasonic transducer for surgical applications is disclosed. The ultrasonic transducer comprises: a back mass; a front mass; an ultrasonic actuator arrangement held between the back mass and the front mass; and an ultrasonic horn arrangement forward of the front mass. The back mass, ultrasonic actuator arrangement, front mass and ultrasonic horn arrangement are arranged along a longitudinal axis of the transducer. Vibrations generated by the ultrasonic actuator arrangement are conducted into the front mass and into the ultrasonic horn arrangement along a vibrational energy transfer path and are amplitude amplified by the ultrasonic horn arrangement. One or more of the back mass, front mass and ultrasonic horn arrangement includes a plurality of openings opening towards the longitudinal axis and intersecting the vibrational energy transfer path and configured to provide an increased mechanical compliance in a direction along the vibrational energy transfer path.

Classes IPC  ?

• A61B 17/32 - Instruments chirurgicaux coupants

Abrégé

The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BRCA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

A system that provides the ability to integrate both diagnostic tissue detection and therapeutic tissue treatment functionality in an implantable medical device (IMD), such as a graft or stent. The system comprises: an IMD having a pair of electrodes configured to contact biological tissue at an implant location; an impedance sensor configured to detect data indicative of a complex impedance of the biological tissue at the electrodes for a plurality of frequencies; and an analysis device configured to determine one or more cell types in the biological tissue using information indicative of variation in phase and magnitude of the complex impedance across the plurality of frequencies. The system may include a signal generator for applying a treatment signal to the same electrodes.

Classes IPC  ?

• A61B 5/0537 - Mesure de la composition du corps par impédance, p. ex. de l’hydratation des tissus ou de la teneur en graisses
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/0538 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps invasive, p. ex. en utilisant un cathéter
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers

Abrégé

A readout integrated circuit (IC) architecture for a tunnelling magnetoresistive (TMR) sensor which uses common mode feedback to achieve a performance level suitable for accurate detection of biomagnetic signals. The architecture uses a three-operational amplifier configuration with chopper stabilization. The architecture may form part of a fully integrated biomagnetic sensor electronics package that includes an array of TMR sensors together with modules for signal amplification and conditioning, data conversion and communication.

Classes IPC  ?

• A61B 5/242 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G01R 33/00 - Dispositions ou appareils pour la mesure des grandeurs magnétiques
• G01R 33/09 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs magnéto-résistifs

Abrégé

A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 μm.

Classes IPC  ?

• A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
• A61M 15/00 - Inhalateurs
• B05B 17/06 - Appareils de pulvérisation ou d'atomisation de liquides ou d'autres matériaux fluides, non couverts par les autres groupes de la présente sous-classe opérant suivant des procédés particuliers utilisant des vibrations ultrasonores
• H03H 9/145 - Moyens d'excitation, p. ex. électrodes, bobines pour réseaux utilisant des ondes acoustiques de surface

Abrégé

The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

Classes IPC  ?

• A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale

Abrégé

Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Classes IPC  ?

• A61K 35/68 - Protozoaires, p. ex. flagelles, amibes, sporozoaires, plasmodium ou toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs
• C12N 15/79 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes

Abrégé

A heat pump system for controlling the internal temperature of a building. The system comprises a compressor, a first heat exchanger, an expansion device and a second heat exchanger which are fluidly coupled together by a flow of refrigerant to define a refrigerant circuit, and a thermal energy storage means which is thermally couplable to the refrigerant circuit to exchange thermal energy with the refrigerant. The heat pump system is configured to be operable in a normal heating mode and in a defrosting mode. In the normal heating mode, thermal energy is transferred from the second heat exchanger into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building. In the defrosting mode thermal energy is transferred from the thermal energy storage means into the refrigerant and transferred from the refrigerant by the first heat exchanger to heat the building and by the second heat exchanger to defrost the second heat exchanger. The heat pump system comprises a switching assembly which is configured to switch between the normal heating and defrosting modes, and wherein the switching assembly is configured, when operating the heat pump system in the defrosting mode, to direct refrigerant exiting the first heat exchanger to flow through the second heat exchanger to cause residual heat in the refrigerant to defrost the second heat exchanger.

Classes IPC  ?

• F25B 47/02 - Cycles de dégivrage

Abrégé

A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.

Classes IPC  ?

• H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche
• G01J 1/44 - Circuits électriques
• G01S 7/4863 - Réseaux des détecteurs, p. ex. portes de transfert de charge
• H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives

Abrégé

The invention relates to methods of increasing stomatal function in plants, which as a result leads to an increase in carbon assimilation and/or water use efficiency and ultimately an increase in yield. In particular the methods of the invention relate to the expression of light-gated potassium channels in the stomatal complex. Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

Classes IPC  ?

• G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques

Abrégé

The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.

Classes IPC  ?

• G01R 1/067 - Sondes de mesure
• G01R 3/00 - Appareils ou procédés spécialement adaptés à la fabrication des appareils de mesure
• C23F 4/00 - Procédés pour enlever des matériaux métalliques des surfaces, non couverts par le groupe ou
• G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet

Abrégé

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

Classes IPC  ?

• A01N 37/46 - Dérivés N-acylés

Abrégé

The present invention relates to analogues of insect neuropeptides having activity against hemipteran and dipteran insects, such as aphids and fruit flies, and their use as insect control agents (e.g. insecticides) and plant protection agents.

Classes IPC  ?

• A01N 37/46 - Dérivés N-acylés
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.

Classes IPC  ?

• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• C07K 14/495 - Facteur de croissance transformant [TGF]
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.

Classes IPC  ?

• G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques

Abrégé

Provided is a fluid handling device having multiple flow pathways through the device. The device has a fluid directing manifold comprising an array of interconnected multi-directional valves, and a plurality of ports in fluid connection with the array. The device also has a controller to set the position of the multi-directional valves. The manifold is configured to provide at least two independent flow paths between a pair of ports within the manifold. Also provided is a method of using the device, and an automated chemical synthesis platform comprising the device.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions

Abrégé

The present invention provides a method for estimating the molecular complexity of a sample, for example to determine whether biotic or synthetic components are present in the sample. The method comprises the steps of (a) performing one of MS/MS, NMR or IR on a sample; (b) determining the unique peaks in the resulting spectrum; and (c) calculating the molecular assembly index of the sample based on the number of unique peaks in the spectrum.

Classes IPC  ?

• G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A surface plasmonic sensing device (10) comprises a substrate (12) and a first array (20) and a second array (22) of localised surface plasmon resonance island structures (20, 22) on the substrate (12). The surface plasmon resonance island structures (20, 22) of the first (20) and second (22) array respectively have first and second surface functionalisation for selective interaction with respective analytes. The first surface functionalisation is different to the second surface functionalisation. The first (20) and second (22) arrays are interspersed with each other to provide a composite array in a main sensing region (14) of the device (10). Also disclosed is a method for manufacturing a surface plasmonic sensing device (10) and a method of analysing a fluid comprising a mixture of two or more analytes. The surface plasmonic sensing device (10) may further comprise a reference region (16) and an auxiliary sensing region (18).

Classes IPC  ?

• G01N 21/552 - Réflexion totale atténuée
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
• G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique

Abrégé

A method and a system for generating a hyper-entangled high-dimensional time-bin frequency-bin state, the method comprising generating a hyper-entangled state composed of a time-bin and frequency-bin encoded state, and individually modifying at least one of: i) the amplitude and ii) the phase of the state components at different frequency-bins and different time-bins of the hyper-entangled state. The system comprises a non-linear medium exited with multiple pulses in broad phase-matching conditions, a frequency mode separator and an amplitude/phase modulator, the frequency mode separator temporally and spatially separating frequency modes of the hyper-entangled state, the amplitude/phase modulator individually modifying at least one of: i) the amplitude (and ii) the phase of the state components at different frequency-bins and different time-bins of the hyper-entangled state.

Classes IPC  ?

• G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique
• G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique

Abrégé

Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem.

Classes IPC  ?

• G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• G06J 1/00 - Dispositions de calcul hybride

Abrégé

The present invention is based on the identification of a network of biomarkers which are characteristic of disease remission in patients with rheumatoid arthritis. The biomarkers provide a sensitive read-out of patient pathological status which allows treatment to be tailored, administered, evaluated and withdrawn in the appropriate clinical circumstances avoiding disease relapse, flare and unnecessary treatment with toxic and costly drugs. Accordingly, the present invention relates to novel diagnostic assays for disease remission in patients with rheumatoid arthritis. The invention also relates to methods, devices and kits for identifying patients in remission, evaluating therapeutic effectiveness in achieving remission and predicting the likelihood of relapse.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/564 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour complexes immunologiques préexistants ou maladies auto-immunes

Abrégé

The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

Classes IPC  ?

• C07D 215/48 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
• A61K 51/04 - Composés organiques

Abrégé

The invention relates to a device (1) for characterising the actimetry of a subject in real time, having a radar (2) transmitting and receiving radar signals and having a software interface for configuring the form of the transmitted signal; means (3) for processing and computing which are connected to the radar (2) and have a classifier (3a) trained using a database, the means (3) for processing and computing being configured to perform, in real time: - acquisition of colour micro-doppler images (6) having a plurality of colour channels (R, V, B), each having micro-doppler signatures (6a) with colour pixels the value of which depends on a reflectivity and a speed of the subject; - processing of the micro-doppler images (6) to compute an image which is referred to as monochromatic and has monochromatic pixels, each having a given monochromatic intensity, from the colour pixels of each colour micro-doppler image; - transformation of the monochromatic image into a binary image through segmentation, according to an intensity threshold, of the monochromatic pixels, producing binary pixels the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel relative to the threshold.

Classes IPC  ?

• G01S 13/00 - Systèmes utilisant la réflexion ou la reradiation d'ondes radio, p. ex. systèmes radarSystèmes analogues utilisant la réflexion ou la reradiation d'ondes dont la nature ou la longueur d'onde sont sans importance ou non spécifiées

Abrégé

A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency-multiplexed reference signal, and feeding the polarization- and frequency-multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.

Classes IPC  ?

• G01B 9/02015 - Interféromètres caractérisés par la configuration du parcours du faisceau
• G01B 9/02001 - Interféromètres caractérisés par la commande ou la génération des propriétés intrinsèques du rayonnement

Abrégé

A system and a method for phase extraction of a multi-path interferometer, the method comprising generating a reference signal of a coherence length longer than an arm length difference of the multi-path interferometer; splitting the reference signal into a frequency shifted reference signal and an unshifted reference signal; recombining the frequency shifted reference signal and the unshifted reference signal into a polarization- and frequency- multiplexed reference signal, and feeding the polarization- and frequency- multiplexed reference signal to the multi-path interferometer; detecting frequency shifted and unshifted output signals of the multi-path interferometer; and determining the interferometer phase from the detected signal.

Classes IPC  ?

• G01B 9/02017 - Interféromètres caractérisés par la configuration du parcours du faisceau avec plusieurs interactions entre l’objet ciblé et les faisceaux lumineux, p. ex. les réflexions des faisceaux provenant de positions différentes

Abrégé

The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.

Classes IPC  ?

• H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

An imaging apparatus configured to obtain a temporally resolvable signal from an entire scene to be imaged. Instead of scanning the scene to build a three-dimensional image, the imaging apparatus maps the temporally resolvable signal from the entire scene to three-dimensional image data using a mapping model, which may comprise a machine learning algorithm. The temporally resolvable signal can be a reflected signal emitted from the scene in response to a measurement signal pulse emitted by the imaging apparatus. The machine learning algorithm may be trained using a training set comprising temporally resolvable signals associated with corresponding three-dimensional images. The measurement signal pulse may be an acoustic signal (e.g. ultrasound), or may comprise visible light, or radiation in the super high frequency (SHF) or extremely high frequency (EHF) ranges.

Classes IPC  ?

• G01S 7/41 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe utilisant l'analyse du signal d'écho pour la caractérisation de la cibleSignature de cibleSurface équivalente de cible
• G01S 13/89 - Radar ou systèmes analogues, spécialement adaptés pour des applications spécifiques pour la cartographie ou la représentation
• G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
• G01S 17/10 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes à modulation d'impulsion interrompues
• G01S 17/89 - Systèmes lidar, spécialement adaptés pour des applications spécifiques pour la cartographie ou l'imagerie
• G06N 3/02 - Réseaux neuronaux

Abrégé

A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

Classes IPC  ?

• H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
• G02F 1/35 - Optique non linéaire
• H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
• H01S 3/067 - Lasers à fibre optique
• H01S 3/13 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude
• H01S 3/136 - Stabilisation de paramètres de sortie de laser, p. ex. fréquence ou amplitude par commande de dispositifs placés dans la cavité

Abrégé

The invention relates to methods of increasing stomatal function in plants, which as a result leads to an increase in carbon assimilation and/or water use efficiency and ultimately an increase in yield. In particular the methods of the invention relate to the expression of light-gated potassium channels in the stomatal complex. Also described are genetically altered plants characterised by the above phenotype as well as methods of producing such plants.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

The invention provides means of diagnosing and treating microvascular angina (MVA). Diagnostic applications of intra-coronary guidewires are provided. Treatment of MVA patients with zibotentan is disclosed. The MVA patient can be identified and selected for treatment via the diagnostic applications provided.

Classes IPC  ?

• A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale

Abrégé

A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Classes IPC  ?

• G01N 21/80 - Indication de la valeur du pH
• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS

Abrégé

The invention relates to CAP2b analogues having activity against hemipteran insects such as aphids, and their use as insect control agents (e.g. insecticides) and plant protection agents. In particular it has been found that a known CAP2b analogue designated 1895, and new CAP2b analogues including molecules designated 2129, 2315, 2316 and 2320, have activity against hemipteran insects and so find use for control of hemipteran insects and plant protection.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A01N 37/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A01M 1/20 - Capture ou destruction des insectes par les poisons, les narcotiques ou le feu

Abrégé

The invention relates to CAP2b analogues having activity against hemipteran insects such as aphids, and their use as insect control agents (e.g. insecticides) and plant protection agents. In particular it has been found that a known CAP2b analogue designated 1895, and new CAP2b analogues including molecules designated 2129, 2315, 2316 and 2320, have activity against hemipteran insects and so find use for control of hemipteran insects and plant protection.

Classes IPC  ?

• A01M 1/20 - Capture ou destruction des insectes par les poisons, les narcotiques ou le feu
• A01N 37/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Abrégé

44 2-288 2-44 2-) in the reaction space; and an ultrasonicator for providing an ultrasonic field at the working electrode.

Classes IPC  ?

• C25B 1/28 - Percomposés
• C25B 9/06 - Cellules comportant des électrodes fixes de dimensions stables; Assemblages de leurs éléments de structure
• C02F 1/46 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques

Abrégé

A method of fabricating a field-effect transistor in which a native oxide layer is removed prior to etching a gate recess. The cleaning step ensures that the etch of the gate recess starts at the same time across an entire sample, such that a uniform gate recess depth and profile can be achieved across an array of field-effect transistors. This results in a highly uniform switch-off voltage for the field-effect transistors in the array.

Classes IPC  ?

• H01L 27/146 - Structures de capteurs d'images
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
• H01L 31/0304 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
• H01L 31/103 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel étant du type PN à homojonction

Abrégé

Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Classes IPC  ?

• A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
• A61K 35/68 - Protozoaires, p. ex. flagelles, amibes, sporozoaires, plasmodium ou toxoplasma
• C07K 14/45 - Toxoplasma
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs
• C12N 15/79 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes

Abrégé

The invention relates to a method of pre-surgical risk stratification of a prostate cancer subject, comprising determining a gene expression profile for phosphodiesterase 4D variant 7 (PDE4D7) in a biological sample obtained from the subject, determining a gene expression profile for DExH-box helicase 9 (DHX9) in the same or another biological sample obtained from the subject, and determining a pre-surgical prognostic risk score for the subject based on the gene expression profile for PDE4D7 and the gene expression profile for DHX9. This may allow for an improved stratification of the subject in a pre-surgical setting that may result in better primary treatment decisions. For instance, the pre-surgical prognostic risk score may allow to make better recommendations on whether to select active surveillance vs. active intervention, e.g., radical prostatectomy, for certain sub-populations of prostate cancer patients.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

Classes IPC  ?

• G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe

Abrégé

The invention provides a chemical computer having a matrix, an input device and an analytical device. The matrix is a plurality of interconnected reaction spaces holding a reaction mixture; the input device is provided to independently address each of a plurality of reaction spaces within the matrix; and the analytical device has a sensor to analyse a reaction characteristic of a reaction mixture in one or more reaction spaces. Also provides are methods for using the chemical computer, and the use of the chemical computer as a logic gate.

Classes IPC  ?

• G06N 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion

Abrégé

A single photon avalanche diode (SPAD) device is presented. The SPAD device comprising: a Si-based avalanche layer formed over an n-type semiconductor contact layer; a p-type charge sheet layer formed in or on the avalanche layer, the p-type charge sheet layer having an in-plane width; a Ge-based absorber layer, formed over the charge sheet layer and/or the avalanche layer, and overlapping the charge sheet layer, the Ge-based absorber layer having an in-plane width; wherein, at least in one in-plane direction, the in-plane width of the Ge-based absorber layer is greater than the in-plane width of the p-type charge sheet layer.

Classes IPC  ?

• H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche