ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (USA)
UNIVERSITY OF HOUSTON (USA)
Inventor
Green, Matthew
Sumerlin, Brent
Robertson, Megan
Niimoto, Kacie
Abstract
A recyclable covalent adaptable network (a sorbent polymer) for direct air capture and method for producing and using the same is disclosed. The method for using the sorbent polymer for capturing carbon dioxide includes creating a pre-polymer through controlled radical polymerization (CRP) of at least one monomer comprising a first monomer, the first monomer having a β-ketoester moiety that is reactive. The method further includes crosslinking the pre-polymer by reacting the β-ketoester moieties of the pre-polymer with a crosslinker having primary amines and secondary amines to form the sorbent polymer which is a covalent adaptable network (CAN) comprising a network of exchangeable enaminone linkages. The method also includes exposing the sorbent polymer to an airflow such that the secondary amines adsorb carbon dioxide from the airflow, and heating the sorbent polymer to release the carbon dioxide adsorbed by the secondary amines of the CAN.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
C08L 33/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
C08F 2/38 - Polymerisation using regulators, e.g. chain terminating agents
2.
HIGH PERFORMANCE TRANSITION METAL BASED NITRIDE CATALYSTS FOR ALKALINE WATER ELECTROLYSIS
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G01N 33/537 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
B01D 15/08 - Selective adsorption, e.g. chromatography
B01D 57/00 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g.
B01D 43/00 - Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
4.
SYSTEMS AND METHODS FOR CONTINUOUS, ACTIVE, AND NON-INTRUSIVE USER AUTHENTICATION
Provided here are systems and method for non-intrusive authentication of a user. Such systems and methods may include in an embodiment a waveform generator to generate a message, encrypt the message, and transmit the encrypted message to one or more transmitters. The system may include a decryption engine to receive a bone conduction signal from one or more receivers, process the bone conduction signal, decrypt the processed bone conduction signal, and separate a bone conduction token portion from the decrypted bone conduction signal. The system may include an authentication engine to analyze the bone conduction signal, authenticate a user for the operation detected based on a comparison of the analyzed bone conduction signal and the pilot portion of the message exceeding a preselected threshold, and verify bone conduction signal authenticity via the bone conduction token portion and the token portion.
G10L 17/04 - Training, enrolment or model building
G06F 21/32 - User authentication using biometric data, e.g. fingerprints, iris scans or voiceprints
G10L 17/02 - Preprocessing operations, e.g. segment selectionPattern representation or modelling, e.g. based on linear discriminant analysis [LDA] or principal componentsFeature selection or extraction
G10L 17/26 - Recognition of special voice characteristics, e.g. for use in lie detectorsRecognition of animal voices
H04L 9/14 - Arrangements for secret or secure communicationsNetwork security protocols using a plurality of keys or algorithms
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
H04M 1/72463 - User interfaces specially adapted for cordless or mobile telephones with means for adapting the functionality of the device according to specific conditions to restrict the functionality of the device
This invention relates to magnetic iron oxide nanoparticles (NPs), and to methods of making the magnetic iron oxide nanoparticles (NPs) with tunable particle sizes and crystallite size. More specifically, this invention provides methods for making highly crystalline iron oxide nanospheres (IONSs) that exhibit enhanced ferrimagnetic (FM) properties. In addition, the method allows precise modulation of the nanoparticle crystallinity, which in turn enables the ability to finely tune their magnetic properties from ferrimagnetic (FM) properties to superparamagnetic (SPM) properties.
A hydrogen storage system comprising (i) a nanoporous solid; (ii) an aqueous fluid-promoter mixture and (iii) one or more pressure-inducing liquids. A method of storing hydrogen comprising contacting a nanoporous solid with an aqueous fluid-promoter mixture under conditions suitable for the formation of a hydrated solid; and contacting the hydrated solid with at least one pressure-inducing liquid under conditions suitable for the formation of a hydrogen storage material.
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
A headset device is described herein comprising a band comprising an outer surface and an inner surface, wherein the band comprises a plurality of EEG sensors located on an inner lateral area of the inner surface, wherein the inner lateral area corresponds to a temporal region of the wearer of the headset, wherein the band comprises at least one EOG sensor located on the inner surface above an eye of the wearer, wherein the band comprises a video camera on the outer surface, wherein the camera is directed in a line of sight of the wearer.
A method is described herein comprising receiving an electroencephalography (EEG) signal from a plurality of EEG sensors during performance of a plurality of tasks, receiving an electrospinography (ESG) signal from a plurality of ESG sensors during the performance of a plurality of tasks, receiving an electromyography data (EMG) signal from a plurality of EMG sensors during the performance of the plurality of tasks, filtering the EEG signal, the ESG signal, and the EMG signal, identifying independent components in the EEG signal for each participant using independent component analysis, wherein the independent components correspond to dipole activity associated with participants' performance of the plurality of tasks, and analyzing the independent components and corresponding ESG signal to determine associations among participant independent components and between each participants independent components and respective ESG signal.
Described herein are compositions and methods for the prevention of pathogens such as conditions in an animal (e.g., a subject). In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.
Methods for spray deposition of large-area covalent organic frameworks may comprise spray depositing a first monomer solution from a first nozzle and a second monomer solution from a second nozzle onto a collection surface, the first monomer solution comprising a first monomer and a first solvent, and second monomer solution comprising a second monomer and a second solvent; wherein the first monomer comprises a diamine and the second monomer comprises a trialdehyde, or the first monomer comprises a triamine and the second monomer comprises a dialdehyde; and reacting the first monomer with the second monomer and optionally a catalyst upon the collection surface to form a covalent organic framework.
B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
C08G 83/00 - Macromolecular compounds not provided for in groups
11.
Detoxification Device Having Heated Filter for Killing Pathogens
A detoxification device for removing pathogens from air within an environment. The detoxification device may include a filtration media for catching and retaining particles larger than about 0.3 micrometers (μm) with an efficiency of at least 99%. The detoxification device may also include a heating element having a metallic foam. The heating element may be heated upon application of an electrical current to the heating element. The heating element may, upon being heated, heat the filtration media to a target temperature that is effective to kill a pathogen.
A61L 9/16 - Disinfection, sterilisation or deodorisation of air using physical phenomena
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
B01D 46/44 - Auxiliary equipment or operation thereof controlling filtration
B01D 46/52 - Particle separators, e.g. dust precipitators, using filters embodying folded material
F24F 8/108 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering using dry filter elements
H05B 3/12 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material
12.
APPARATUS, SUBSTRATE, AND METHOD FOR INTERCELLULAR DELIVERY OF PAYLOADS BY PHOTOPORATION
An apparatus for payload delivery to a cell includes a laser source configured to generate laser energy and a substrate implanted with photoacoustic launch pads. The apparatus is configured to create a pore in a cell membrane by: absorbing the laser energy by the substrate; increasing the temperature of the photoacoustic launch pads in response to the laser energy; creating a vapor nanobubble by causing fluid surrounding the cell to absorb heat and expand in response to the increased temperature of the photoacoustic launch pads; causing the vapor nanobubble to collapse, disrupting a membrane of the cell; forming a pore in the cell membrane in response to disrupting the membrane of the cell; and delivering a payload into the cell based on causing fluid surrounding the cell containing the payload to enter the cell via the pore.
NNN-heterocyclic carbene functionalized transition metal dichalcogenides. This invention also relates to articles of manufacture comprising N-heterocyclic carbene functionalized transition metal dichalcogenides.
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
Disclosed are probes based on papilloma virus and modified SV40 comprising a green fluorescent protein marker gene that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
15.
PROBE FOR UNIVERSAL DETECTION OF CIRCULATING TUMOR CELLS
Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
16.
ALL-SOLID-STATE LITHIUM SECONDARY BATTERIES AND METHODS OF PREPARING THE SAME
Embodiments pertain to an interlayer suitable for use in solid-state batteries. Such interlayers generally include: (1) a plurality of carbon nanomaterials; and (2) a plurality of magnesium (Mg) nanoparticles uniformly dispersed on the carbon nanomaterials. After lithiation, the interlayers also include a percolating network operational for regulating ion flux through the interlayer due to the volume expansion of Mg nanoparticles. Additional embodiments pertain to solid-state batteries that include such interlayers, methods of forming such interlayers, and methods of forming solid-state batteries that include the interlayers.
H01M 10/0561 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of inorganic materials only
H01M 10/05 - Accumulators with non-aqueous electrolyte
17.
MAGNETIC IRON OXIDE NANOPARTICLE BASED SENSORS AND BIOSENSORS AND METHODS OF USE THEREOF
This invention relates to magnetic iron oxide nanoparticle-based sensors and biosensors. This invention also relates to sensing methods utilizing magnetic iron oxide nanoparticle-based sensors. This invention also relates to biosensing methods utilizing magnetic iron oxide nanoparticle-based biosensors. A key approach is to utilize magnetic iron oxide nanoparticles (spherical shape) with appropriate particle size and magnetic properties (superparamagnetic and ferrimagnetic properties) to enhance the efficiency, sensitivity, and selectivity of magnetic nanoparticle-based sensors and biosensors by selecting nanoparticles with suitable particle size and crystallite size. Another key approach is to utilize magnetic iron oxide nanoparticles (cuboid shape) with appropriate particle size and ferrimagnetic properties to enhance the efficiency, sensitivity, and selectivity of magnetic nanoparticle-based sensors and biosensors by selecting nanoparticles with suitable particle size.
COMBINATION OF IAP INHIBITORS AND CELLULAR KINASE INHIBITORS, SUCH AS PONATINIB, FOR USE IN THE TREATMENT OF CANCER OR PULMONARY DISEASES, SUCH AS COPD, CYSTIC FIBROSIS, PULMONARY FIBROSIS AND COVID-19
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 11/00 - Drugs for disorders of the respiratory system
This invention relates to the utilization of superpararmagnetic polycrystalline iron oxide nanoparticles for magnetic hperthermia applications and methods. The present invention provides a magnetic hyperthermia method for treating a condition in a subject, the method comprising: obtaining at least one superparamagnetic nanoparticle, wherein the at least one superparamagnetic nanoparticle comprises a plurality of iron oxide primary crystals, wherein the plurality of iron oxide primary crystals comprise a plurality of crystallites.
The present disclosure relates to the detection of analytes in high volumetric flow applications. Particular embodiments relate to the use of fluorescence polarization/anisotropy based for detection of analytes in a flow cell. In one testing format, an analyte of interest is probed with reagents containing fluorescent labeled recognition elements. When present in a sample or portion of a sample, thee labeled analyte produces a shift in fluorescence polarization/anisotropy/intensity/lifetime as the output signal following the binding of the recognition elements to the analytes.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
21.
TRANSITION METAL OXIDE SORBENTS AND TRANSITION METAL HYDROXIDE SORBENTS FOR CARBON DIOXIDE CAPTURE
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
22.
METHOD AND SYSTEM FOR BUILDING-LEVEL CLASSIFICATION OF NATURAL DISASTER-INDUCED BUILDING DAMAGE
Method for classification of building damage induced by a natural disaster event; the method comprising: - obtaining microwave radar remote sensing data of a geographical region impacted by the natural disaster event, the remote sensing data having been generated after the natural disaster event; - obtaining building data from at least one geographical database, wherein the building data pertains to areas of buildings at outer edges of outside walls of said buildings; - enriching the remote sensing data with the building data; - segmenting the enriched remote sensing data into segments corresponding with buildings based on the building data; - extracting textural features from the segmented remote sensing data; - obtaining a machine learning, ML, classifier which has been trained to classify building damage of each segment of the segmented remote sensing data into a building damage level classification comprising at least two building damage levels; wherein the training is based on remote sensing data of a plurality of different types of natural disaster events and of at least two different types of geographical regions; and - classifying building damage of each segment of the segmented remote sensing data into the building damage level classification, using the ML classifier.
G06V 10/54 - Extraction of image or video features relating to texture
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 20/17 - Terrestrial scenes taken from planes or by drones
A soleus contraction measurement system includes a sensor configured to measure rotational movement when positioned on a user's foot with an X-axis oriented laterally across the user's foot, a Y-axis oriented parallel to the user's foot, a Z-axis orthogonal to the X-axis and the Y-axis, and a positive X-axis rotational movement corresponding to an increasing ankle angle, and a memory storing computer-executable instructions for controlling a processor to: measure an X-axis rotational movement, identify a positive X-axis rotational movement as a plantarflexion and a negative X-axis rotational movement as an ankle dorsiflexion, deem the plantarflexion a performed soleus contraction when the plantarflexion is immediately followed by the ankle dorsiflexion for two consecutive cycles of plantarflexion and ankle dorsiflexion, and cause performance information regarding the performed soleus contractions to be communicated.
An overhead signage structure includes a first vertical post and a second vertical post laterally-spaced from the first vertical post. Each post has a vertically oriented central axis, a lower end fixably coupled to the ground, and an upper end distal the ground. In addition, the signage structure includes a horizontal beam comprising a first decommissioned wind turbine blade. The beam has a horizontally oriented central axis, a first end, and a second end opposite the first end. The first end of the beam is fixably coupled to the upper end of the first vertical post and the second end of the beam is fixably coupled to the upper end of the second vertical post. Further, the signage structure includes one or more signs fixably coupled to the beam.
E01F 9/673 - Upright bodies, e.g. marker posts or bollardsSupports for road signs characterised by means for fixing for holding sign posts or the like
E01F 9/654 - Upright bodies, e.g. marker posts or bollardsSupports for road signs characterised by form or by structural features, e.g. for enabling displacement or deflection in the form of three-dimensional bodies, e.g. conesUpright bodies, e.g. marker posts or bollardsSupports for road signs characterised by form or by structural features, e.g. for enabling displacement or deflection capable of assuming three-dimensional form, e.g. by inflation or erection to form a geometric body
25.
METHOD FOR REDUCING THE VISCOSITY OF HEAVY OIL FOR EXTRACTION, TRANSPORT IN PIPES, AND CLEANING THEREOF
A composition composed of highly reactive metal particles that are ball milled, bead milled or blended and dispersed in a solvent with/without polymer for significantly reducing the viscosity of heavy oil for extracting viscous heavy oil, such that the composition reacts with water and oil to produce heat, H2 gas, and hydroxide to lower the oil viscosity and facilitate extraction from an underground formation or transport of heavy oil, such as in a pipe from one place to another place.
A blood glucose monitoring system having an insulin pump operational to administer insulin to the subject, sensors associated with the subject and operational to measure the blood glucose levels of a subject, and a computing device in electronic communication with the insulin pump. The computing device includes computer readable storage mediums having program code embodied therewith. The computing device includes a closed-loop insulin delivery algorithm trained to predict the blood glucose level of the subject. The algorithm includes a data-driven multi-step- ahead blood glucose predictor integrated with a linear time-varying model predictive control law. The computing device includes programming instructions for feeding the subject's blood glucose level into the algorithm, using the algorithm to predict if the blood glucose level of the subject is expected to reach a level representing hypoglycemia or hyperglycemia, and transmitting insulin administration instructions to the insulin pump based on the prediction.
A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
27.
APPARATUS AND METHOD OF IMPROVING RETINAL IMAGE QUALITY WITH A SLOTTED TRANSMISSIVE REGION
A corrective lens for correcting aberrations of an eye of a patient includes a central region formed in the center of the corrective lens preventing light transmission. The corrective lens further includes a slotted transmissive region formed in the central region, the slotted transmissive region allowing light transmission therethrough.
Exemplary embodiments are directed to a system having a resonant cavity at least partially filled with a dielectric material. The system also includes a laser source configured to emit a laser beam through a hole in the resonant cavity. An optical sensor captures at least a portion of laser beam that as passed through resonant cavity and generates a voltage based on the captured laser beam.
Embodiments pertain to an interlayer suitable for use in solid-state batteries. Such interlayers generally include: (1) a plurality of carbon nanomaterials; and (2) a plurality of metallic nanoparticles uniformly dispersed on the carbon nanomaterials. The interlayers also include a percolating network operational for regulating ion flux through the interlayer. Additional embodiments pertain to solid- state batteries that include such interlayers, methods of forming such interlayers, and methods of forming solid-state batteries that include the interlayers.
Embodiments of the present disclosure pertain to a nucleic acid sequence that includes a promoter operatively linked to a heterologous nucleotide sequence encoding a cyclic GMP-AMP synthase (cGAS) polypeptide. The nucleotide sequence also encodes a stabilizing peptide, such as a small ubiquitin modifying protein (SUMO) polypeptide. Further embodiments of the present disclosure pertain to fusion proteins that include a cGAS polypeptide and a stabilizing peptide. Additional embodiments of the present disclosure pertain to a recombinant cell that expresses a heterologous nucleotide sequence of the present disclosure. Further embodiments of the present disclosure pertain to methods of utilizing the recombinant cells of the present disclosure to produce 2'3' cyclic GMP-AMP (2'3'-cGAMP).
Elbow erosion monitoring is of great significance to the safety of pipeline systems and maintenance personnel. A percussion method is used to monitor pipe erosion. Under different erosion degrees, the mass reduction of the elbow is measured by high-precision electronic scale and the residual thickness of the elbow is detected by telescoping gauge. Machine learning algorithm, the K- Nearest Neighbor and recurrent network method are employed to identify the different wall thickness level and erosion mass level.
E21B 47/107 - Locating fluid leaks, intrusions or movements using acoustic means
E21B 47/14 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling using acoustic waves
G01H 9/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
A chamber of a hybrid chemical and physical vapor deposition (HybCPVD) provides high-quality and uniform films on relatively large multiple wafers per growth run at reasonably high deposition rates using a scalable high-throughput process. Transition-metal-alloyed 1II-N single-crystalline and textured thin films are epitaxially and non-epitaxially deposited on a suitable substrate (of. for example, silicon or a metal such as aluminum or titanium) by providing a mixture of various gases in a deposition/growth chamber. The precursors for the chemical reactions include vapor phase of elements of transition metals, vapor phase of chlorides, and vapor phase of hydride. This growth technique provides high growth rate and high-quality epitaxial materials.
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
33.
CRACK-FREE ULTRAWIDE-BANDGAP GROUP-III-NITRIDE SEMICONDUCTOR FILMS DEPOSITED ON SILICON SUBSTRATE
A method of forming a single-crystalline group-III-nitride (III-N) thick film includes epitaxially growing or depositing, on a silicon (Si) (111) substrate, one or more metallic interlayers or a superlattice structure including a plurality of pairs of a metallic layer and a semiconductor layer, epitaxially growing or depositing, on a top layer of the superlattice structure that is located opposite to the Si (111) substrate or on a top layer of the one or more metallic interlayers that is located opposite to the Si (111) substrate, the single-crystalline group-III-N thick film, epitaxially growing or depositing, on a top layer of the single-crystalline group-III-N thick film, a secondary substrate, removing the one or more metallic interlayers or the metallic layers from the superlattice structure to separate the Si (111) substrate, and transferring the single-crystalline group-III-N thick film on to the secondary substrate.
Described to compositions and methods for recycling lithium-ion battery materials. More specifically, described herein to acid- and base-free compositions and methods for the recovery of lithium and other valuable materials such as Ni, Co, Mn, Cu, Al, graphite, etc. from lithium-containing battery materials for subsequent purification and reuse. Certain methods described herein for recovering lithium from a lithium-ion battery comprise isolating a bulk material from a cathode or the cathode and an anode of a lithium-ion battery, the bulk material comprising lithium, reacting the bulk material with a persulfate compound to form lithium sulfate or a hydrate thereof, and recovering the lithium sulfate or the hydrate thereof.
DEUTSCHES ZENTRUM FÜR LUFT- UND RAUMFAHRT E.V. (Germany)
ENVEO ENVIRONMENTAL EARTH OBSERVATION INFORMATION TECHNOLOGY GMBH (Austria)
UNIVERSITY OF HOUSTON SYSTEM (USA)
Inventor
Gonzalez, Carolina
Rizzoli, Paola
Dell'Amore, Luca
Milillo, Pietro
Nagler, Thomas
Abstract
The invention refers to a computer-implemented method for calibrating a pair of digital elevation maps (DEMI, DEM2), where the digital elevation maps (DEMI, DEM2) of the pair have been acquired from measurements of a first radar sensor equipment (RE1) and indicate for different time points the height of a predetermined terrain (TR) on a surface of a celestial body, wherein the method processes a time series (ts) of SAR images (TSIM) of the predetermined terrain (TR) acquired from measurements of a second radar sensor equipment (RE2), the method comprising the following steps: a) determining candidate calibration points (ccp) from the time series (ts) of SAR images (TSIM) based on dispersion measures (D) of respective pixel positions within the SAR images (TSIM) of the time series (ts); b) identifying pixel positions as calibration points (cp) within the digital elevation maps (DM1, DM2) of the pair based on the candidate calibration points (ccp); c) determining height value differences (Δ) between the digital elevation maps (DEMI, DEM2) of the pair at the calibration points (cp); d) fitting a two-dimensional curve (CS) to the height value differences (A) at the calibration points (cp), the two-dimensional curve (CS) describing the height value differences (Δ) over the pixel positions representing corresponding points within the predetermined terrain (TR); e) correcting the height values (hvl, hv2) of one digital elevation map (DEMI, DEM2) of the pair by the height value differences (Δ) of the two-dimensional curve (CS).
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
G01S 13/87 - Combinations of radar systems, e.g. primary radar and secondary radar
G01S 13/90 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging using synthetic aperture techniques
36.
SYSTEMS AND METHODS FOR PROVIDING DELIBERATION PLATFORMS
In an embodiment, a deliberation experience system includes processor-executable instructions to: generate a deliberation platform including a plurality of forums and a manager dashboard to facilitate monitoring deliberation in each forum of the plurality of forums, the manager dashboard presented on a manager user device; receive a first input from the manager user device indicative of assigning a respective set of participant user devices to each forum and communicatively couple the respective set of participant user devices to each forum; receive a second input from the manager user device indicative of a selected issue guide of a plurality of issue guides, the selected issue guide including a plurality of discussion topics; and instruct a computer-automated moderator to initiate a guided discussion on each forum by progressing through each discussion topic of the selected issue guide in each forum and moderating discussion between participants on each forum.
Nanoparticles and nanonetworks formed of these nanoparticles are provided. Methods for forming such nanoparticles and nanonetworks are also provided, as well as uses of the nanoparticles and/or nanonetworks, including their use for drug delivery.
A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
38.
SYSTEMS AND METHODS FOR IMPLEMENTING DEEP LEARNING MODELS USING ENVIRONMENT DISCOVERY
A method for training a deep learning model includes training a first sorting deep learning model (DLM) using a training dataset to predict a presence of a target attribute in a first datapoint of the training dataset based on a presence of a first environmental attribute in the first datapoint, training a second sorting DLM using the training dataset to predict the absence of the target attribute in a second datapoint of the training dataset based on a presence of the first environmental attribute in the second datapoint, comparing a first difficulty score with a second difficulty score of the second sorting DLM, assigning the datapoints to a first environment in response to the first difficulty score being less than the second difficulty score, and assigning the datapoints to a second environment in response to the first difficulty score being greater than the second difficulty score.
A system for forecasting energy consumption by vehicles in a mixed-vehicle fleet. The system includes neural network(s) that generate a predictive function for vehicles in each of a number of classes (e.g., electric vehicles, hybrid vehicles, internal combustion vehicles, vehicle models, model years, etc.). To capture both the generalizable patterns that govern energy consumption across all vehicle classes and the features and relationships that are specific to each class, the neural network(s) include a multi-task learning model that includes shared layers for all of the classes of vehicles and a set of vehicle-specific layers for each class. In some of those embodiments, for example to predict to energy consumption of an additional class with limited data, the neural networks further include an inductive transfer learning model that includes the shared layers transferred from the multi-task learning model and vehicle-specific layers for the additional class.
H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
G07C 5/08 - Registering or indicating performance data other than driving, working, idle, or waiting time, with or without registering driving, working, idle, or waiting time
Loss of cardiomyocytes underlies most causes of heart failure, and normal repair processes are inadequate to deal with extensive myocardial damage. The inventors have identified mutations of the N-terminus of serum respose factor (SRF)'s MADS box, termed STEMINs, that block cardiac differentiation, but also powerfully activate the stem cell marker genes Nanog and Octomer 4, as well as cyclins, which promotes adult myocyte replication. SRF Stemin mutations are not cardiac-specific, and also propel mammalian fibroblasts into a proliferative state. Thus, STEMINs may be useful for regeneration of all tissue and organ types, by activating partial pluripotency programs and enhacing repair by increased cell replication. Following withdrawal of STEMINs, the cells then return to normal cell identity.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A corrective lens for correcting of myopia of an eye of a patient includes an internal diffractive region and a concave spherical surface. The corrective lens controls longitudinal chromatic aberration by changing a longitudinal focus of blue and red light relative to a focal point of green light.
A nail trimming assistive device includes a support frame having a brace portion defining a brace receptacle for receiving a user's hand and a support portion defining a support receptacle for receiving a separate support member. The nail trimming assistive device additionally includes a clamping member configured to apply a clamping force to the support member when received in the support receptacle, an actuator to displace the clamping member along a clamping axis into and out of engagement with the support member, and a flexible retaining member having an open configuration in which a free end thereof is spaced from the support frame, and a closed configuration in which the free end is coupled to the support frame.
A method of preparing a water electrolysis catalyst comprising subjecting at least a portion of a substrate to a temperature of from about 400 °C to about 1500 °C for a time period of from about 5 seconds to about 30 minutes to form a heat-treated substrate; contacting the heat-treated substrate with a fluid comprising a transition metal salt under conditions suitable for formation of the water electrolysis catalyst wherein the catalyst has an overpotential ranging from about 100 mV to about 1000 mV in a water electrolysis reaction at a current density of 500 mA/cm2.
A method of manufacturing a polymer electrolyte membrane comprising solubilizing an ionomer in a first solvent to produce a solubilized ionomer; thermally-treating the solubilized ionomer to produce a thermally-treated solubilized ionomer;solubilizing a structuring agent in a second solvent to form a solubilized structuring agent; and contacting the thermally-treated solubilized ionomer with the solubilized structuring agent to form a composite solution; and casting the composite solution onto a substrate to form a cast membrane. An electrochemical device comprising a polymer membrane wherein the polymer membrane comprises a sulfonic acid containing-polymer and a structuring agent characterized by an extent of entanglement of from about 5% to about 25%.
H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers
H01M 8/1032 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having sulfur, e.g. sulfonated-polyethersulfones [S-PES]
H01M 8/1046 - Mixtures of at least one polymer and at least one additive
47.
CORRECTIVE LENS AND METHOD FOR CONTROLLING MYOPIA EFFECTS OR EYE ABERRATIONS
A corrective lens for controlling myopia of an eye of a patient. The corrective lens includes a central region at least partially preventing light transmission, and a light transmissive region formed at least through a center area of the central region.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE PARIS-SACLAY (France)
UNIVERSITY OF HOUSTON (USA)
Inventor
Fox, George E
Tirumalai, Madhan
Tran, Quyen D
Calvet, Laurie
Abstract
The present inventions concerns a method for identifying at least one biological characteristic of a complex molecular structure, the method comprising producing an interaction network representation of the complex molecular structure from a structural file, wherein said representation comprises nodes connected by edges, and using the interaction network representation to identify said at least one biological characteristic of the complex molecular structure. The present inventions also concerns a computer program comprising software instructions which, when executed by a computer, implement a method according to the invention.
G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
49.
CONTORTED POLYAMIDE MEMBRANES AND METHODS OF USE THEREOF
This invention relates to contorted polyamide polymers. This invention also relates to contorted polyamide membranes, methods of making the contorted polyamide membranes, and methods of using the contorted polyamide membranes.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
Peptoid compositions targeting RAS proteins and methods of treatment of cancers using these peptoid compositions are described here. Also provided are fatty acid conjugated peptoid compositions that interact with KRAS, HRAS, or NRAS proteins. Certain peptoid compositions inhibit function of a KRAS protein in a cancer cell. The KRAS protein can be a mutant or wild type KRAS protein. The peptoid composition can be administered along with a MEK inhibitor or an ERK inhibitor.
An imaging system for capturing images of the periphery of an eye of a patient is disclosed. An optical signal source provides an optical source light. A microlens array is placed at the pupil conjugate of the patient. An image sensor receives focused light from the microlens array. A horizontal scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in the horizontal plane to the eye. A vertical scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in a vertical plane to the eye. A controller controls the horizontal scan system and the vertical scan system. The horizontal scan system captures images in a horizontal scan. The vertical scan system captures images in a vertical scan. Both the horizontal scan system and the vertical scan system are activated to capture images in a diagonal scan.
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
A centrifugal mixing system includes an outer shell having an inlet end and an outlet end, an inner cylinder rotatably positioned in the outer shell including a heterogenous pattern including one or more untreated surfaces and one or more hydrophobic surfaces where the one or more hydrophobic surfaces, and a motor coupled to the inner cylinder and configured to rotate the inner cylinder within and relative to the outer shell about a rotational axis to mix a fluid received from the fluid inlet and disposed in an annulus formed between the inner cylinder and the outer shell in response to rotation of the inner cylinder about the rotational axis.
B01F 27/053 - Stirrers characterised by their elements, materials or mechanical properties characterised by their materials
B01F 27/111 - Centrifugal stirrers, i.e. stirrers with radial outletsStirrers of the turbine type, e.g. with means to guide the flow
B01F 27/94 - Mixers with rotary stirring devices in fixed receptaclesKneaders with stirrers rotating about a substantially vertical axis with rotary cylinders or cones
53.
ENSURING A SMOOTH USER EXPERIENCE IN A MULTI-USER AUGMENTED REALITY SYSTEM
A method, computer program product and system for ensuring a smooth user experience in a multi-user augmented reality system. A computing device ("master") shares a quadtree data structure of an image with a virtual 3D object with another computing device ("slave"), which inputs the quadtree data structure into a machine learning (ML) model to obtain ML results which is used by the slave to render an image of the virtual 3D object in the field of view of the slave, which may experience slight offset. The slave transforms the rendered image into a quadtree data structure, which is shared with the master along with the ML results. The master then inputs the received information into its ML model. The ML results from the ML model may include correction values, which may be applied to the image previously rendered by the master. This iterative process continues until corrections are not necessary.
The present disclosure pertains to compositions suitable for use in differentiating cardiac progenitor cells to cells that resemble cardiac Purkinje cells. Additional embodiments pertain to methods of generating such differentiated cardiac cells by exposing cardiac progenitor cells to the compositions. The present disclosure also pertains to methods of treating or preventing a cardiovascular disease in a subject by administering the compositions or differentiated cardiac cells to the subject. Further embodiments pertain to methods of generating a cardiac tissue by exposing cardiac progenitor cells to a composition of the present disclosure and associating the cardiac progenitor cells with a tissue scaffold. The present disclosure also pertains to the use of the differentiated cardiac progenitor cells to assess the efficacy of one or more compounds in the treatment or prevention of a cardiovascular disease. The present disclosure also pertains to the differentiated cardiac cells and cardiac tissues that include them.
Embodiments of the present disclosure pertains to one or more novel peptoids, derivatives thereof, multimers thereof, and combinations thereof. The peptoids may be suitable for use in treating or preventing a cancer in a subject, detecting a cancer in a subject, or as research and development tools. Further embodiments pertain to methods of inhibiting the growth of cancer cells by exposing the cancer cells to the peptoids. Additional embodiments of the present disclosure pertain to methods of treating or preventing a cancer in a subject by administering the peptoids to the subject. Further embodiments pertain to methods of detecting cancer in a subject by exposing cells susceptible of being cancerous to the peptoids, detecting the presence or absence of vimentin associated with cells susceptible of being cancerous, and correlating the presence or absence of the vimentin to the presence or absence of the cancer in the subject.
A system and method to detect cognitive impairment is disclosed. A head mounted sensor is operable to be worn by a user. The head mounted sensor includes an optical sensor for collecting an optical response from a region of interest in the brain of the user. A user input interface receives a user test input from a test device executing a stimulation test to the user. A controller is coupled to the sensor device and the user input interface. The controller collects optical response data from the optical sensor and test input data from the test device. The controller determines a hemoglobin level in the region of interest based on the optical response data. The determined hemoglobin level in the region of interest is correlated with the user test input in response to the stimulation test. Brain activity is evaluated based on the determined hemoglobin level.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G06V 40/00 - Recognition of biometric, human-related or animal-related patterns in image or video data
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
Mycobacterium tuberculosisMycobacterium tuberculosis. Additional embodiments of the present disclosure pertain to methods of treating or preventing tuberculosis in a subject by administering a composition of the present disclosure to the subject.
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61P 31/06 - Antibacterial agents for tuberculosis
A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A hydrogen storage device comprising (i) hydrogen gas and (ii) a host framework material. A hydrogen discharge device comprising (i) hydrogen gas and (ii) a host framework material. A method of storing hydrogen comprising introducing hydrogen gas to a host framework material comprising a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof under conditions suitable for the formation of hydrogen gas hydrates. A battery comprising a host framework material comprising hydrogen gas hydrates wherein the host framework material comprises a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof.
Embodiments of the present disclosure pertain to methods of separating nucleic acids from a sample by applying the sample to a fiber-based electrophoresis medium and generating an electric field across the fiber-based electrophoresis medium, where the generated electric field induces migration and separation of the nucleic acids across the fiber-based electrophoresis medium. The methods of the present disclosure may also include a step of detecting one or more of the separated nucleic acids on the fiber-based electrophoresis medium, diagnosing a disease or condition based on the detecting, and implementing a treatment decision based on the diagnosis. Additional embodiments of the present disclosure pertain to nucleic acid separation systems for separating nucleic acids and methods of making them.
B01L 7/00 - Heating or cooling apparatusHeat insulating devices
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
60.
HYDROGEN STORAGE MATERIALS AND METHODS OF USE THEREOF
C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
61.
DOWNREGULATION OF RHODOPSIN AS A THERAPEUTIC STRATEGY FOR PERIPHERIN-2-ASSOCIATED INHERITED RETINAL DISORDERS
PRPH2PRPH2-associatcd inherited retinal disorders. Preferred embodiments for the downregulation of rhodopsin utilize antisense oligonucleotides (ASO) that lead to producing less rhodopsin such as by degradation of rhodopsin mRNA.
Embodiments of the present disclosure pertain to a housing unit that includes: (1) a container with a top area and a base area; (2) a cavity within the container between the top area and the base area and configured to house an object; and (3) an opening on the top area, where the opening includes (a) a plurality of shutter elements surrounding the opening, and (b) an actuation system operatively connected to the shutter elements and configured to adjust the positions of the shutter elements relative to the opening. Additional embodiments of the present disclosure pertain to methods of altering objects by placing an object in a cavity of a housing unit through its opening and then altering the object in the cavity. The housing units and methods of the present disclosure may be utilized to alter objects for various purposes, such as vascular anastomosis training.
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
Embodiments of the present disclosure pertain to methods of enriching one or more molecules in a medium by applying a spatially non-uniform alternating current electric field (AC electric field) to the medium, where the AC electric field enriches the molecules in the medium through initiating electromigration of the molecules. The methods may also include steps of sensing and/or purifying the molecules. Additional embodiments of the present disclosure pertain to systems for enriching one or more molecules, where the system includes a housing unit operational to house a medium that includes the molecules to be enriched, and an electrode operational to be electrically connected to the medium and apply an AC electric field to the medium.
C07C 251/86 - Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
C02F 1/26 - Treatment of water, waste water, or sewage by extraction
C07C 249/16 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
C07D 213/76 - Nitrogen atoms to which a second hetero atom is attached
Organic semiconductor microelectronic devices (OSMDs) can be fabricated through direct 3D printing using a gel-pen technique. The technique utilizes in situ electrochemical deposition of the meniscus provided by a wet hydrogel cartridge at the electrode interface. Bioactive proteins such as laminin, fibronectin and. glucose oxidase can be incorporated in the gel and entrapped within the OSMDs.
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
An ultra-thin film superconducting tape and method for fabricating same is disclosed. Embodiments are directed to a superconducting tape being fabricated by processes which include removing a portion of the superconducting tape's substrate subsequent the substrate's initial formation, whereby a thickness of the superconducting tape is reduced to 15-80 μm.
In an embodiment, the present disclosure pertains to electric field generators that include a signal generator electrically connected to a power amplifier, a impedance matching circuit electrically connected to the power amplifier, and a power divider electrically connected to the impedance matching circuit and to at least one of a first wall, a second wall, a third wall, a fourth wall, or a base area. In an additional embodiment, the present disclosure pertains to method of determining radio frequency (RF)-induced heating on a medical device utilizing an electric field generator of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making electric field generators for testing a medical device.
Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
A template for the production of nanowires or nanostructures includes a substrate, a first neutral layer disposed on the substrate, a vertically aligned lamellar block copolymer film layer disposed on the first neutral layer, and a second neutral layer disposed on the block copolymer film layer. The vertically aligned lamellar block copolymer film layer can be formed from a block copolymer via Shear-Directed Self-Assembly (SDSA) using a cold zone annealing soft shear (CZA-SS) methodology.
A system for tracking an eye of a user includes one or more piezoelectric sensors positionable on the face of the user, and an eye tracking computer system in signal communication with the one or more piezoelectric sensors so as to receive signals from the one or more piezoelectric sensors, wherein the computer system is configured to detect movement in at least one direction of the eye of the user based on the signals received by the computer system from the one or more piezoelectric sensors when the one or more piezoelectric sensors are positioned on the face of the user in one or more locations each spaced from the eyelids of the user.
A method for reducing the metal content in a water source includes dissolving an amount of a solubilizing anion in a low grade water comprising one or more cations under conditions suitable to formed a suspension comprising insoluble solubilizing anion-cation complexes wherein the anion comprises; and separating the insoluble solubilizing anion-cation complexes from the suspension to obtain a higher grade water having a metal content reduced by from about 50% to about 100%.
This invention relates to catalysts for microwave reforming of hydrocarbons, systems incorporing the catalysts for microwave reforming of hydrocarbons, and methods for using the catalysts for microwave reforming of hydrocarbons.
This invention relates to an mRNA-based vaccine composition for strains of herpes simplex virus (HSV), such as herpes simplex virus-2 (HSV-2). The mRNA vaccine composition comprises a combination of herpesvirus glycoprotein D (gD) and gB-pf mRNA, either alone or in combination with gE and/or gC mRNA.
Described herein are polymers comprising a terminus having a structure according to formula (1):
wherein R is a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic.
C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
77.
CONTROLLING BUOYANCY OF UNDERWATER DEVICE USING FUEL CELLS AND PROPELLERS
An underwater device with buoyancy control as well as a method and computer program product for buoyancy control of an underwater device. Upon receiving an estimate of a current depth of the underwater device, a calculation is performed to determine the difference between the estimated current depth of the underwater device and the target. Based on such a difference exceeding a threshold value, an input to fuel cells in the underwater device is generated to either produce a net gas rate which is accumulated by flexible membranes to gain a volume which generates a positive buoyancy force or to intake gasses which generates a negative buoyancy force. The positive buoyancy force and the negative buoyancy force are used to control the depth of the underwater device to reach a target depth from the current depth.
F03B 13/00 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates
Provided here are graphene composite materials and methods for producing a composite material containing magnetically aligned graphene nanosheets. One such method includes the steps of (a) dispersing graphene nanosheets and one or more monomers or polymers in a solution including a solvent to form a dilute dispersion; (b) evaporating the solvent from the dilute dispersion to form a concentrated dispersion; (c) applying a magnetic field to the dilute dispersion or the concentrated dispersion to align the GNS therein; and (d) curing the one or more monomers or polymers in the concentrated dispersion to produce the composite material.
A method, computer program product and system for improving the accuracy in artificial intelligence modeling in recognizing patterns and drawings conclusions in a manner that emulates human expertise. An arbitrary distribution of data is received. A free energy surface is constructed, in a memory, that encodes the arbitrary distribution of data, where correlations in the encoded data correspond to separate individual minima on the free energy surface. Information may then be retrieved from the free energy surface, such as via interrogation of the multiple energy functions used to encode the arbitrary distribution of data.
Interconnected zeolite nanosheets with a structural motif resembling self-pillared pentasil zeolites are synthesized through the use of MEL or MFI-type zeolites as crystalline seeds. The use of MEL- or MFI-type zeolites as crystalline seeds induces the spontaneous formation of pillared zeolites, thus avoiding, for the first time, the use of any organic or branching template for the crystallization of these hierarchical structures.
A force application system for placement on and removal from an actuable latch with a robotic arm includes a driving pad configured for attachment to the actuable latch, a force application mechanism configured to increase an input force to an amplified output force that is applied by the force application mechanism to the driving pad, and a frame for engagement by the robotic arm.
Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.
The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture, wherein the stem cells are derived from stratified epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.
INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (USA)
Inventor
Degterev, Alexei
Duddupudi, Anantha Lakshmi
Cuny, Gregory
Shabahang, Shirin
Balachandran, Siddharth
Lee, Seungheon
Abstract
Disclosed are substituted, heterocycle compounds. The substituted heterocycles disclosed herein are shown to be useful in activating necroptosis by activation of MLKL and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
Provided are improved oncolytic viruses with increased bystander cell killing and induced anti-tumor immunity. The oncolytic viruses include an oncolytic herpes virus backbone genetically modified to encode a tumor cell binding component and an immunoglobulin (Ig) binding component.
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C07K 14/485 - Epidermal growth factor [EGF], i.e. urogastrone
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
Embodiments of the present disclosure pertain to methods and clinical decision support systems for distinguishing between a first and a second condition in a subject. Additional embodiments of the present disclosure pertain to computer-implemented methods of distinguishing between the first and the second condition in a subject. Further embodiments of the present disclosure pertain to computing devices that are operable to distinguish between the first and the second condition in a subject.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
89.
ONCOLYTIC VIRUS FOR SYSTEMIC DELIVERY AND ENHANCED ANTI-TUMOR ACTIVITIES
This invention relates to oncolytic viruses which are more resistant to neutralization and phagocytosis by immune systems, and methods for their preparation and treatment of disorders and diseases (such as cancer) with them. Described herein is an oncolytic Herpes Simplex Virus Type 1 (HSV-1) or Herpes Simplex Virus Type 2 (HSV-2) treated in immune sera that contain a high level of anti-HSV antibodies. In one preferred embodiment, the oncolytic virus includes an extracellular CD47 domain inserted into the N-terminus of a glycoprotein in order to inhibit phagocyte activity. The oncolytic virus is suitable for systemic administration for the treatment of cancer.
A combination therapy for use in treatment of substance abuse disorders, including alcohol use disorder (AUD) and opioid use disorder (OUD), includes both mitragynine (MG) and naltrexone (NTX). NTX is understood to be a mu opioid antagonist that is expected to block MG's analgesic effects. However, combining MG and NTX therefore results in a unique, unexpected, and beneficial treatment that decreases alcohol self-administration to a greater extent than either alone.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
A61P 25/30 - Drugs for disorders of the nervous system for treating abuse or dependence
91.
Nickel catalysts with single metal cations for homopolymerization and copolymerization
A computer-implemented method for detecting or monitoring subsurface events includes receiving a data signal obtained from a subsurface region, and performing a continuous wavelet transform whereby a continuous wavelet is superimposed on the received data signal to determine one or more wavelet transform coefficients. The method further includes determining a signal energy from the one or more wavelet transform coefficients at a plurality of distinct scales, and detecting an occurrence of a subsurface event based on the signal energy.
G01V 1/36 - Effecting static or dynamic corrections on records, e.g. correcting spreadCorrelating seismic signalsEliminating effects of unwanted energy
G01V 3/38 - Processing data, e.g. for analysis, for interpretation or for correction
E21B 49/00 - Testing the nature of borehole wallsFormation testingMethods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells
E21B 43/00 - Methods or apparatus for obtaining oil, gas, water, soluble or meltable materials or a slurry of minerals from wells
93.
Nickel catalysts with single alkali ions for homopolymerization and copolymerization
Embodiments of the present disclosure pertain to modified cells that include a fusion protein of NPC intracellular cholesterol transporter 2 protein (NPC2) and another protein. Additional embodiments of the present disclosure pertain to methods of delivering a protein to a target cell by associating the target cell with a modified cell of the present disclosure, which includes a fusion protein of NPC2 and the protein to be delivered. Further embodiments of the present disclosure pertain to methods of treating or preventing a condition in a subject by administering to the subject a modified cell of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making the modified cells of the present disclosure by introducing a fusion protein of the present disclosure to cells.
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A system for image augmentation includes a processor and a memory. The memory includes instructions stored thereon, which when executed by the processor cause the system to access a first image and a second image, generate a path including points, perform a time-continuous transformation of a first distribution of pixels of the first image to a second distribution of pixels of the second image within a time interval along the path based on a mean-field game, and generate an augmented dataset based on the time-continuous transformation. The points start from the first image and end at the second image. The points include augmented images. The augmented images retain a shape of the first image and the second image.
A nuclear magnetic resonance (NMR) power supply system and method are disclosed. The architecture adopts a two-stage topology to reduce the required capacitance by over ten times, leading to a four-fold improvement in power density. The first stage is an isolated converter that only supplies average power, therefore input filter and transformer sizes can be reduced. The second stage is a fast response DC-DC converter followed by a RF transmitter to produce a pulsed RF signal, so that the mid-point voltage after the first stage can be allowed to droop considerably, leading to much smaller sized capacitors. These and other embodiments enforce the isolated converter to only transfer average power, which reduces the power rating and the volume of the system's transformer.
Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The at least one rRNA fragment includes at least one domain that associates with the tRNA fragments. The at least one rRNA fragment catalyzes the synthesis of the peptide through peptidyl transfer of the amino acids from the tRNA fragments independently of messenger RNA (mRNA) templates. Additionally, the peptidyl transfer occurs independently of proteins. Further embodiments of the present disclosure pertain to systems for synthesizing a peptide. Such systems include the rRNA fragments of the present disclosure and optionally a plurality of tRNA fragments.
Provided herein are compositions containing zileuton formulated for parenteral administration and/or extended use. Methods of treatment are directed to subjects who would benefit from extended use of zileuton to provide renal protective effects.
The present disclosure relates to analytic mapping of metagenomic and hydrocarbon footprints of geologic subzones. A plurality of DNA profiles are generated based on a set of distinct geological specimens from each well of a plurality of wells. BioGeo markers, BioGeo signatures and a BioGeo matrix are generated based on the plurality of DNA profiles.
