Abstract

A metal organic chemical vapor deposition (MOCVD) device for manufacturing superconducting tapes and a method of fabricating superconducting tapes is disclosed. The device includes an ohmic heat terminal assembly to heat a superconductor substrate tape through ohmic heating. The assembly includes a first roller exterior to a housing and configured to heat multiple superconductor substrate tapes and guide the superconductor substrate tapes to multiple tape tracks and a second roller exterior to the housing and configured to heat the multiple superconductor substrate tapes and guide the heated superconductor substrate tapes out of the multiple tape tracks. Each of the multiple tape tracks includes a first precursor flow channel configured to supply longitudinal laminar precursor flow for deposition on one side of the superconductor substrate tape and a first wall shield flow channel configured to supply longitudinal shield gas flow on the one side of the superconductor substrate tape.

IPC Classes  ?

• H10N 60/01 - Manufacture or treatment
• C23C 14/12 - Organic material
• C23C 14/54 - Controlling or regulating the coating process
• C23C 16/02 - Pretreatment of the material to be coated
• C23C 16/18 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of metallic material from metallo-organic compounds
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• C23C 16/54 - Apparatus specially adapted for continuous coating
• H01B 1/20 - Conductive material dispersed in non-conductive organic material
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

xx 1-xx 2-yy yy 2xx 1-x-x- δδ2-yy yy 2x yxxx ∈ (0.6, 1])]. The present disclosure also pertains to thermoelectric modules that include the compositions. Additionally, the present disclosure pertains to methods of converting energy from a heat source to electricity by applying the heat source to a thermoelectric module. The present disclosure also pertains to methods of designing a composition with simultaneous band convergence. The present disclosure also pertains to steps of testing the thermal or temporal stability of the composition.

IPC Classes  ?

• H10N 10/853 - Thermoelectric active materials comprising inorganic compositions comprising arsenic, antimony or bismuth
• C22C 12/00 - Alloys based on antimony or bismuth
• C04B 35/515 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides

Abstract

Substituted phenylpyridine compounds are disclosed. Also disclosed is the use of the phenylpyridine compounds in methods of treatment and for inhibiting RIPK2 and/or NOD2 cell signaling.

IPC Classes  ?

• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 213/61 - Halogen atoms or nitro radicals

Abstract

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

IPC Classes  ?

• A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
• A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein are compounds and derivatives thereof for use as inhibitors of receptor interacting kinase 3 (RIPK3). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with RIPK3 activity, including inflammatory and degenerative diseases and disorders.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/13 - Amines, e.g. amantadine
• C07D 401/02 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 487/02 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains two hetero rings
• C07D 487/04 - Ortho-condensed systems
• A61K 31/33 - Heterocyclic compounds
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

A device comprising a wearable cap comprising at least one sensor component, wherein the at least one sensor component comprises a sensor and a holder, wherein the holder is integrated into the wearable cap, wherein the holder is configured to receive the sensor, wherein a lower surface of the sensor extends through the holder and comprises a conductive element configured to contact a scalp of a wearable cap user, the at least one sensor component comprising two attachment components, wherein the attachment components are affixed to a surface of the wearable cap at opposing ends of the holder, the at least one sensor component comprising a tensioning band, wherein the tensioning band is secured at both ends to the respective attachment components, wherein the tensioning band in the secured position passes over an upper surface of the sensor and generates a downward force on the sensor and holder.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]

Abstract

Presently disclosed is a linker useful for conjugating a protein or peptide that is labeled by an alkyne group to a biotin moiety, and methods for making and using the linker. One use of the linker is to identify or purify alkyne-tagged peptides. In such methods, the linker is joined to the alkyne group by a click reaction, and then the biotin-conjugated peptides are immobilized on an avidin- or streptavidin-coated substrate. Unbound peptides or proteins are washed away and then the immobilized peptides or proteins are cleaved from the substrate, preferably by a mild acid treatment. The thus isolated peptides can be analyzed by a variety of methods, e.g., to prepare a profile of labeled sites in a living cell.

IPC Classes  ?

• C07K 17/06 - Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07D 213/30 - Oxygen atoms
• C07D 495/04 - Ortho-condensed systems

Abstract

Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.

IPC Classes  ?

• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61P 25/08 - AntiepilepticsAnticonvulsants

Abstract

An apparatus used with supplied power for treating air in an environment and method of use. A housing is mobile in the environment and has an intake and an exhaust. At least one prime mover is disposed in the housing and is operable to move the air in the environment through the housing from the intake to the exhaust. At least one permeable barrier is disposed in the housing and is configured to impede the moved air flow therethrough up to an impedance threshold. The permeable barrier is in electrical communication to the supplied power and is heated to a surface temperature.

IPC Classes  ?

• B01D 46/42 - Auxiliary equipment or operation thereof
• A61L 9/20 - Ultraviolet radiation
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
• B01D 46/44 - Auxiliary equipment or operation thereof controlling filtration
• B60H 3/06 - Filtering
• F24F 8/10 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
• F24F 8/22 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by sterilisation using UV light

Abstract

An isolated, modified gamma-glutamyl transpeptidase (GOT) enzyme with nucleotide of SEQ ID NO; 1 or SEQ ID NO:2 and encoding the protein of SEQ ID NO: 3, wherein the enzyme is coupled to a polyethylene glycol (PEG). The modified GGT enzyme depletes circulating glutamine without impacting circulating asparagine in mammals, increases circulating cystine/cystine in mammals, can be used in combination with L-cyst(e)inase to treat cancers, can be used with anti-TIGIT antibodies to treat cancers, can be used as an immunosuppressive agent and induces G-CSF and GM-CSF expression in mammals.

IPC Classes  ?

• A61K 38/45 - Transferases (2)
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61P 35/00 - Antineoplastic agents
• C12N 9/10 - Transferases (2.)

Abstract

Embodiments of the present disclosure pertain to a composition that includes a particle, an antigen, and a modulator. The modulator may include, without limitation, an agonist, an activator of the immune system, or combinations thereof. The antigen may be operable to elicit an immune response in a subject against respiratory syncytial virus (RSV). Additional embodiments of the present disclosure pertain to methods of treating or preventing a respiratory infection in a subject by administering a composition of the present disclosure to the subject.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61P 31/14 - Antivirals for RNA viruses
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
• C07K 14/115 - Paramyxoviridae, e.g. parainfluenza virus

Abstract

A purification device and method for treating air flow of an air handling system. A high-efficiency particulate air (HEPA) filter can be disposed across a plenum of the purification device that is configured for passage of the air flow. A heater can be disposed across the plenum and may have a permeable barrier that is configured to allow the air flow to pass therethrough. A metal material of the permeable barrier can be connected in electrical communication to a supplied power. The permeable barrier can have an active surface area configured to interact with a pathogen of the air flow and can be heated by the supplied power to a surface temperature directed to kill the pathogen.

IPC Classes  ?

• B01D 46/42 - Auxiliary equipment or operation thereof
• A61L 9/20 - Ultraviolet radiation
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
• B01D 46/44 - Auxiliary equipment or operation thereof controlling filtration
• B60H 3/06 - Filtering
• F24F 8/10 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
• F24F 8/22 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by sterilisation using UV light

Abstract

This invention relates to gallium zeolites. This invention also relates to systems and methods utilizing the gallium zeolites.

IPC Classes  ?

• C07C 1/24 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by elimination of water
• B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
• B01J 29/40 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
• B01J 29/70 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of types characterised by their specific structure not provided for in groups

Abstract

The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.

IPC Classes  ?

• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - OintmentsBases therefor
• A61K 9/51 - Nanocapsules
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 35/00 - Antineoplastic agents

Abstract

A system and a computer implemented method are disclosed to model breast shape using three-dimensional spherical harmonics with adjustable parameters to modulate breast size, projection, and/or ptosis. The method includes receiving a 3D image including a breast, identifying the breast in the 3D image, extracting 3D image data of the breast from the 3D image, forming a closed object using the 3D image data of the breast to create a zero-genus surface, mapping the 3D image data of the breast to a predefined template using spherical coordinates, and determining a 3D spherical harmonic descriptor of the 3D image data of the breast.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A system includes a function generator configured to generate a plurality of signals that are transmitted from the function generator, through a first transducer, and to a battery. The system also includes a data acquisition system configured to measure a plurality of responses that are transmitted from the battery, through a second transducer, and to the data acquisition system. The responses include a plurality of first responses of the battery in response to first signals, and a second response of the battery in response to a second signal. The system also includes a computing system configured to train a machine learning model based upon the first responses and a plurality of corresponding actual SoC values to produce a trained machine learning model. The trained machine learning model is then configured to predict the SoC value of the battery based upon the second response.

IPC Classes  ?

• G01R 31/382 - Arrangements for monitoring battery or accumulator variables, e.g. SoC
• B60L 58/12 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries responding to state of charge [SoC]
• G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables

Abstract

A method of rapidly determining a UGT-transferase substrate includes contacting a UGT-transferase with a UDP-sugar conjugate and a probe to form an assay mixture, subjecting the assay mixture to reaction conditions to form a reacted mixture, contacting the reacted mixture with a UDP-reactive dye under conditions suitable to associate the UDP with the UDP-reactive dye, and spectrophotometrically determining the amount of free UDP, wherein if the concentration of free UDP is greater than a concentration of free UDP in a reference sample prepared in the absence of the UGT-transferase, then the probe molecule is a designated a substrate.

IPC Classes  ?

• C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A method for oil recovery includes inputting into a computer system depletion data and rock and fluid properties of a reservoir. The method also includes computing, with the computer system, a difference between a producing current gas-oil ratio and a solution gas-oil ratio to provide a free gas oil ratio. In addition, the method includes referring, with the computer system, to a gas-oil relative permeability curve of the reservoir. Further, the method includes matching, with the computer system, the free gas oil ratio to a gas saturation on the gas-oil relative permeability curve to provide a free gas saturation. Still further, the method includes calculating, with the computer system, a current oil saturation of the hydrocarbon reservoir. Moreover, the method includes determining, with the computer system, that a current reservoir pressure is less than a bubble point pressure. The method also includes calculating, with the computer system, a time to repressure the hydrocarbon reservoir by waterflooding. In addition, the method includes calculating, with the computer system, a number of wells for waterflooding. Further, the method includes comparing, with the computer system, the data related to properties of the hydrocarbon reservoir to oil recovery screening criteria. Still further, the method includes selecting a flooding technique from a plurality of flooding techniques, with the computer system, based on satisfying the oil recovery screening criteria with the data related to properties of the hydrocarbon reservoir. Moreover, the method includes flooding the reservoir with the flooding technique.

IPC Classes  ?

• G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]
• C09K 8/594 - Compositions used in combination with injected gas
• E21B 43/16 - Enhanced recovery methods for obtaining hydrocarbons
• E21B 43/20 - Displacing by water
• G06Q 50/02 - AgricultureFishingForestryMining

Abstract

Organic charge storage materials capable of storing magnesium ions with fast kinetics are disclosed. The organic charge storage materials include bis-benzoquinone derivatives. The bis-benzoquinone derivatives stabilize the materials so that high energy (for example, greater than 600 Wh/kg) and stable cycling (for example, greater than 50% retention after 15 cycles) are simultaneously achieved. Energy storage devices including the bis-benzoquinone derivatives are also disclosed.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• C07C 50/04 - Benzoquinones, i.e. C6H4O2
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids

Abstract

A bio-inspired autonomous underwater vehicle (BAUV) for inspecting subsea equipment, the BAUV including a body extending between a front end and a rear end, a caudal fin coupled to the rear end of the body for providing thrust to the BAUV, an electric motor positioned within the body and including a mechanical motor output coupled to the caudal fin for adjusting a magnitude of the thrust provided by the caudal fin, an electromechanical servo positioned within the body and including a mechanical servo output coupled to caudal fin for adjusting a direction of the thrust provided by the caudal fin, a camera supported by the body for providing images of the external environment, and an onboard controller in signal communication with the motor, the servo, and the camera for controlling the operation of the motor and the servo based on images captured by the camera.

IPC Classes  ?

• B63G 8/00 - Underwater vessels, e.g. submarines
• B63H 1/36 - Swinging flaps, e.g. fishtail type
• G06N 3/008 - Artificial life, i.e. computing arrangements simulating life based on physical entities controlled by simulated intelligence so as to replicate intelligent life forms, e.g. based on robots replicating pets or humans in their appearance or behaviour
• G06T 5/73 - DeblurringSharpening
• G01N 33/18 - Water
• B63C 11/52 - Tools specially adapted for working underwater, not otherwise provided for

Abstract

The present disclosure is directed to oral compositions and methods of use thereof. The oral composition comprises one or more comprising absorbent or absorbing complex, such as charcoal, silica, diatomaceous earth, bentonite, kaolin, sodium aluminosilicate, synthetic, surface modified or coated absorbent/adsorbent, providing scavenging for drugs/metabolites/toxins/bioagents. The composition, such as a gum, will be taken orally by a user and transfer a drug/metabolite/toxin/bioagent from saliva of said user to the composition and then removed.

IPC Classes  ?

• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A61K 8/25 - SiliconCompounds thereof
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 8/73 - Polysaccharides

Abstract

A method of estimating a micro-seismic cloud related to a hydraulic fracturing operation. The method includes receiving a treating pressure signal generated during hydraulic fracture propagation, calculating a complex wavelet transform coefficient on the received treating pressure signal, calculating energy of the received treating pressure signal at multiple scales to create a signal-energy scalogram, normalizing the signal-energy scalogram to create a normalized signal-energy scalogram, and establishing a correlation between signatures of dynamic fracture propagation modes identified in the normalized signal-energy scalogram and corresponding fracture propagation mode influence on temporal development of a micro-seismic events cloud.

IPC Classes  ?

• G01V 1/30 - Analysis
• E21B 43/26 - Methods for stimulating production by forming crevices or fractures
• G01V 1/50 - Analysing data

Abstract

The present disclosure provides methods of predicting, quantifying, and/or treating high-risk opioid addiction.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

The present disclosure describes a miniarray that includes a substrate having on one surface thereof an immobilized capture antibody that specifically binds VSIG4 antigen and an assay area of immobilized human double-stranded DNA (to capture anti-dsDNA antibody). Assay areas of the miniarray can further include immobilized capture antibodies that specifically bind ALCAM antigen, TNFRSF1b antigen, OPN antigen, IGFBP2 antigen and VCAM1 antigen. Also disclosed are a cassette for conveniently handling the miniarray and kits and methods for a point of care immunoassay that can distinguish among healthy patients, patients having flaring Lupus Nephritis and patients having inactive Lupus Nephritis.

IPC Classes  ?

• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
• A61P 37/00 - Drugs for immunological or allergic disorders
• C12Q 1/6804 - Nucleic acid analysis using immunogens

Abstract

1-xx0.20.80.8N catalysts, particularly under high-current alkaline conditions, in water electrolysis for hydrogen and oxygen production.

IPC Classes  ?

• C25B 1/02 - Hydrogen or oxygen
• B01J 23/28 - Molybdenum
• B01J 23/75 - Cobalt
• B01J 23/755 - Nickel
• B01J 23/887 - Molybdenum containing in addition other metals, oxides or hydroxides provided for in groups
• B01J 27/24 - Nitrogen compounds
• B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
• B01J 23/68 - Silver or gold with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium

Abstract

A recyclable covalent adaptable network (a sorbent polymer) for direct air capture and method for producing and using the same is disclosed. The method for using the sorbent polymer for capturing carbon dioxide includes creating a pre-polymer through controlled radical polymerization (CRP) of at least one monomer comprising a first monomer, the first monomer having a β-ketoester moiety that is reactive. The method further includes crosslinking the pre-polymer by reacting the β-ketoester moieties of the pre-polymer with a crosslinker having primary amines and secondary amines to form the sorbent polymer which is a covalent adaptable network (CAN) comprising a network of exchangeable enaminone linkages. The method also includes exposing the sorbent polymer to an airflow such that the secondary amines adsorb carbon dioxide from the airflow, and heating the sorbent polymer to release the carbon dioxide adsorbed by the secondary amines of the CAN.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
• C08L 33/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
• C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
• C08F 2/38 - Polymerisation using regulators, e.g. chain terminating agents

Abstract

Disclosed herein is a separation matrix comprising an immunoglobulin binding protein and methods of using the same.

IPC Classes  ?

• C07K 1/14 - ExtractionSeparationPurification
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/537 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
• B01D 15/08 - Selective adsorption, e.g. chromatography
• B01D 57/00 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g.
• B01D 43/00 - Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration

Abstract

Provided here are systems and method for non-intrusive authentication of a user. Such systems and methods may include in an embodiment a waveform generator to generate a message, encrypt the message, and transmit the encrypted message to one or more transmitters. The system may include a decryption engine to receive a bone conduction signal from one or more receivers, process the bone conduction signal, decrypt the processed bone conduction signal, and separate a bone conduction token portion from the decrypted bone conduction signal. The system may include an authentication engine to analyze the bone conduction signal, authenticate a user for the operation detected based on a comparison of the analyzed bone conduction signal and the pilot portion of the message exceeding a preselected threshold, and verify bone conduction signal authenticity via the bone conduction token portion and the token portion.

IPC Classes  ?

• G10L 17/04 - Training, enrolment or model building
• G06F 21/32 - User authentication using biometric data, e.g. fingerprints, iris scans or voiceprints
• G10L 17/02 - Preprocessing operations, e.g. segment selectionPattern representation or modelling, e.g. based on linear discriminant analysis [LDA] or principal componentsFeature selection or extraction
• G10L 17/26 - Recognition of special voice characteristics, e.g. for use in lie detectorsRecognition of animal voices
• G10L 21/0208 - Noise filtering
• H04L 9/08 - Key distribution
• H04L 9/14 - Arrangements for secret or secure communicationsNetwork security protocols using a plurality of keys or algorithms
• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
• H04M 1/72463 - User interfaces specially adapted for cordless or mobile telephones with means for adapting the functionality of the device according to specific conditions to restrict the functionality of the device
• H04R 1/10 - EarpiecesAttachments therefor

Abstract

This invention relates to magnetic iron oxide nanoparticles (NPs), and to methods of making the magnetic iron oxide nanoparticles (NPs) with tunable particle sizes and crystallite size. More specifically, this invention provides methods for making highly crystalline iron oxide nanospheres (IONSs) that exhibit enhanced ferrimagnetic (FM) properties. In addition, the method allows precise modulation of the nanoparticle crystallinity, which in turn enables the ability to finely tune their magnetic properties from ferrimagnetic (FM) properties to superparamagnetic (SPM) properties.

IPC Classes  ?

• B82Y 25/00 - Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82Y 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

A hydrogen storage system comprising (i) a nanoporous solid; (ii) an aqueous fluid-promoter mixture and (iii) one or more pressure-inducing liquids. A method of storing hydrogen comprising contacting a nanoporous solid with an aqueous fluid-promoter mixture under conditions suitable for the formation of a hydrated solid; and contacting the hydrated solid with at least one pressure-inducing liquid under conditions suitable for the formation of a hydrogen storage material.

IPC Classes  ?

• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/16 - Alumino-silicates
• B01J 20/18 - Synthetic zeolitic molecular sieves
• C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
• C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof

Abstract

A headset device is described herein comprising a band comprising an outer surface and an inner surface, wherein the band comprises a plurality of EEG sensors located on an inner lateral area of the inner surface, wherein the inner lateral area corresponds to a temporal region of the wearer of the headset, wherein the band comprises at least one EOG sensor located on the inner surface above an eye of the wearer, wherein the band comprises a video camera on the outer surface, wherein the camera is directed in a line of sight of the wearer.

IPC Classes  ?

• A61B 5/256 - Wearable electrodes, e.g. having straps or bands
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/297 - Bioelectric electrodes therefor specially adapted for particular uses for electrooculography [EOG]Bioelectric electrodes therefor specially adapted for particular uses for electroretinography [ERG]
• A61B 5/31 - Input circuits therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/372 - Analysis of electroencephalograms
• A61B 5/282 - Holders for multiple electrodes

Abstract

A method is described herein comprising receiving an electroencephalography (EEG) signal from a plurality of EEG sensors during performance of a plurality of tasks, receiving an electrospinography (ESG) signal from a plurality of ESG sensors during the performance of a plurality of tasks, receiving an electromyography data (EMG) signal from a plurality of EMG sensors during the performance of the plurality of tasks, filtering the EEG signal, the ESG signal, and the EMG signal, identifying independent components in the EEG signal for each participant using independent component analysis, wherein the independent components correspond to dipole activity associated with participants' performance of the plurality of tasks, and analyzing the independent components and corresponding ESG signal to determine associations among participant independent components and between each participants independent components and respective ESG signal.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/369 - Electroencephalography [EEG]
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Described herein are compositions and methods for the prevention of pathogens such as conditions in an animal (e.g., a subject). In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/1271 - Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/14 - Antivirals for RNA viruses
• A61P 37/04 - Immunostimulants
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

Methods for spray deposition of large-area covalent organic frameworks may comprise spray depositing a first monomer solution from a first nozzle and a second monomer solution from a second nozzle onto a collection surface, the first monomer solution comprising a first monomer and a first solvent, and second monomer solution comprising a second monomer and a second solvent; wherein the first monomer comprises a diamine and the second monomer comprises a trialdehyde, or the first monomer comprises a triamine and the second monomer comprises a dialdehyde; and reacting the first monomer with the second monomer and optionally a catalyst upon the collection surface to form a covalent organic framework.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/60 - Polyamines
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• C08G 83/00 - Macromolecular compounds not provided for in groups

Abstract

A detoxification device for removing pathogens from air within an environment. The detoxification device may include a filtration media for catching and retaining particles larger than about 0.3 micrometers (μm) with an efficiency of at least 99%. The detoxification device may also include a heating element having a metallic foam. The heating element may be heated upon application of an electrical current to the heating element. The heating element may, upon being heated, heat the filtration media to a target temperature that is effective to kill a pathogen.

IPC Classes  ?

• B01D 46/42 - Auxiliary equipment or operation thereof
• A61L 9/014 - Deodorant compositions containing sorbent material, e.g. activated carbon
• A61L 9/16 - Disinfection, sterilisation or deodorisation of air using physical phenomena
• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
• B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
• B01D 46/44 - Auxiliary equipment or operation thereof controlling filtration
• B01D 46/52 - Particle separators, e.g. dust precipitators, using filters embodying folded material
• F24F 8/108 - Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering using dry filter elements
• H05B 1/02 - Automatic switching arrangements specially adapted to heating apparatus
• H05B 3/12 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material

Abstract

An apparatus for payload delivery to a cell includes a laser source configured to generate laser energy and a substrate implanted with photoacoustic launch pads. The apparatus is configured to create a pore in a cell membrane by: absorbing the laser energy by the substrate; increasing the temperature of the photoacoustic launch pads in response to the laser energy; creating a vapor nanobubble by causing fluid surrounding the cell to absorb heat and expand in response to the increased temperature of the photoacoustic launch pads; causing the vapor nanobubble to collapse, disrupting a membrane of the cell; forming a pore in the cell membrane in response to disrupting the membrane of the cell; and delivering a payload into the cell based on causing fluid surrounding the cell containing the payload to enter the cell via the pore.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

NNN-heterocyclic carbene functionalized transition metal dichalcogenides. This invention also relates to articles of manufacture comprising N-heterocyclic carbene functionalized transition metal dichalcogenides.

IPC Classes  ?

• B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
• C23C 14/12 - Organic material
• C07D 235/04 - BenzimidazolesHydrogenated benzimidazoles

Abstract

Disclosed are probes based on papilloma virus and modified SV40 comprising a green fluorescent protein marker gene that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 15/86 - Viral vectors
• C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 15/86 - Viral vectors
• C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Embodiments pertain to an interlayer suitable for use in solid-state batteries. Such interlayers generally include: (1) a plurality of carbon nanomaterials; and (2) a plurality of magnesium (Mg) nanoparticles uniformly dispersed on the carbon nanomaterials. After lithiation, the interlayers also include a percolating network operational for regulating ion flux through the interlayer due to the volume expansion of Mg nanoparticles. Additional embodiments pertain to solid-state batteries that include such interlayers, methods of forming such interlayers, and methods of forming solid-state batteries that include the interlayers.

IPC Classes  ?

• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials
• H01M 10/0561 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of inorganic materials only
• H01M 10/05 - Accumulators with non-aqueous electrolyte

Abstract

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

IPC Classes  ?

• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents

Abstract

This invention relates to magnetic iron oxide nanoparticle-based sensors and biosensors. This invention also relates to sensing methods utilizing magnetic iron oxide nanoparticle-based sensors. This invention also relates to biosensing methods utilizing magnetic iron oxide nanoparticle-based biosensors. A key approach is to utilize magnetic iron oxide nanoparticles (spherical shape) with appropriate particle size and magnetic properties (superparamagnetic and ferrimagnetic properties) to enhance the efficiency, sensitivity, and selectivity of magnetic nanoparticle-based sensors and biosensors by selecting nanoparticles with suitable particle size and crystallite size. Another key approach is to utilize magnetic iron oxide nanoparticles (cuboid shape) with appropriate particle size and ferrimagnetic properties to enhance the efficiency, sensitivity, and selectivity of magnetic nanoparticle-based sensors and biosensors by selecting nanoparticles with suitable particle size.

IPC Classes  ?

• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

This invention relates to the utilization of superpararmagnetic polycrystalline iron oxide nanoparticles for magnetic hperthermia applications and methods. The present invention provides a magnetic hyperthermia method for treating a condition in a subject, the method comprising: obtaining at least one superparamagnetic nanoparticle, wherein the at least one superparamagnetic nanoparticle comprises a plurality of iron oxide primary crystals, wherein the plurality of iron oxide primary crystals comprise a plurality of crystallites.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/14 - Particulate form, e.g. powders
• A61P 35/00 - Antineoplastic agents
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 25/00 - Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• C01G 49/08 - Ferroso-ferric oxide [Fe3O4]

Abstract

The present disclosure relates to the detection of analytes in high volumetric flow applications. Particular embodiments relate to the use of fluorescence polarization/anisotropy based for detection of analytes in a flow cell. In one testing format, an analyte of interest is probed with reagents containing fluorescent labeled recognition elements. When present in a sample or portion of a sample, thee labeled analyte produces a shift in fluorescence polarization/anisotropy/intensity/lifetime as the output signal following the binding of the recognition elements to the analytes.

IPC Classes  ?

• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

Abstract

22222 from ambient air.

IPC Classes  ?

• B01D 53/1475 -
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

Method for classification of building damage induced by a natural disaster event; the method comprising: - obtaining microwave radar remote sensing data of a geographical region impacted by the natural disaster event, the remote sensing data having been generated after the natural disaster event; - obtaining building data from at least one geographical database, wherein the building data pertains to areas of buildings at outer edges of outside walls of said buildings; - enriching the remote sensing data with the building data; - segmenting the enriched remote sensing data into segments corresponding with buildings based on the building data; - extracting textural features from the segmented remote sensing data; - obtaining a machine learning, ML, classifier which has been trained to classify building damage of each segment of the segmented remote sensing data into a building damage level classification comprising at least two building damage levels; wherein the training is based on remote sensing data of a plurality of different types of natural disaster events and of at least two different types of geographical regions; and - classifying building damage of each segment of the segmented remote sensing data into the building damage level classification, using the ML classifier.

IPC Classes  ?

• G06V 10/54 - Extraction of image or video features relating to texture
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 20/17 - Terrestrial scenes taken from planes or by drones
• G06V 20/10 - Terrestrial scenes
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting

Abstract

A soleus contraction measurement system includes a sensor configured to measure rotational movement when positioned on a user's foot with an X-axis oriented laterally across the user's foot, a Y-axis oriented parallel to the user's foot, a Z-axis orthogonal to the X-axis and the Y-axis, and a positive X-axis rotational movement corresponding to an increasing ankle angle, and a memory storing computer-executable instructions for controlling a processor to: measure an X-axis rotational movement, identify a positive X-axis rotational movement as a plantarflexion and a negative X-axis rotational movement as an ankle dorsiflexion, deem the plantarflexion a performed soleus contraction when the plantarflexion is immediately followed by the ankle dorsiflexion for two consecutive cycles of plantarflexion and ankle dorsiflexion, and cause performance information regarding the performed soleus contractions to be communicated.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

An overhead signage structure includes a first vertical post and a second vertical post laterally-spaced from the first vertical post. Each post has a vertically oriented central axis, a lower end fixably coupled to the ground, and an upper end distal the ground. In addition, the signage structure includes a horizontal beam comprising a first decommissioned wind turbine blade. The beam has a horizontally oriented central axis, a first end, and a second end opposite the first end. The first end of the beam is fixably coupled to the upper end of the first vertical post and the second end of the beam is fixably coupled to the upper end of the second vertical post. Further, the signage structure includes one or more signs fixably coupled to the beam.

IPC Classes  ?

• E01F 9/673 - Upright bodies, e.g. marker posts or bollardsSupports for road signs characterised by means for fixing for holding sign posts or the like
• E01F 9/654 - Upright bodies, e.g. marker posts or bollardsSupports for road signs characterised by form or by structural features, e.g. for enabling displacement or deflection in the form of three-dimensional bodies, e.g. conesUpright bodies, e.g. marker posts or bollardsSupports for road signs characterised by form or by structural features, e.g. for enabling displacement or deflection capable of assuming three-dimensional form, e.g. by inflation or erection to form a geometric body

Abstract

A composition composed of highly reactive metal particles that are ball milled, bead milled or blended and dispersed in a solvent with/without polymer for significantly reducing the viscosity of heavy oil for extracting viscous heavy oil, such that the composition reacts with water and oil to produce heat, H2 gas, and hydroxide to lower the oil viscosity and facilitate extraction from an underground formation or transport of heavy oil, such as in a pipe from one place to another place.

IPC Classes  ?

• C09K 8/594 - Compositions used in combination with injected gas
• C09K 8/592 - Compositions used in combination with generated heat, e.g. by steam injection
• E21B 43/20 - Displacing by water

Abstract

A blood glucose monitoring system having an insulin pump operational to administer insulin to the subject, sensors associated with the subject and operational to measure the blood glucose levels of a subject, and a computing device in electronic communication with the insulin pump. The computing device includes computer readable storage mediums having program code embodied therewith. The computing device includes a closed-loop insulin delivery algorithm trained to predict the blood glucose level of the subject. The algorithm includes a data-driven multi-step- ahead blood glucose predictor integrated with a linear time-varying model predictive control law. The computing device includes programming instructions for feeding the subject's blood glucose level into the algorithm, using the algorithm to predict if the blood glucose level of the subject is expected to reach a level representing hypoglycemia or hyperglycemia, and transmitting insulin administration instructions to the insulin pump based on the prediction.

IPC Classes  ?

• A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
• A61M 5/142 - Pressure infusion, e.g. using pumps
• A61M 5/145 - Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
• G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A corrective lens for correcting aberrations of an eye of a patient includes a central region formed in the center of the corrective lens preventing light transmission. The corrective lens further includes a slotted transmissive region formed in the central region, the slotted transmissive region allowing light transmission therethrough.

IPC Classes  ?

• G02C 7/02 - LensesLens systems
• G02C 7/04 - Contact lenses for the eyes

Abstract

Exemplary embodiments are directed to a system having a resonant cavity at least partially filled with a dielectric material. The system also includes a laser source configured to emit a laser beam through a hole in the resonant cavity. An optical sensor captures at least a portion of laser beam that as passed through resonant cavity and generates a voltage based on the captured laser beam.

IPC Classes  ?

• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01R 13/00 - Arrangements for displaying electric variables or waveforms

Abstract

Embodiments pertain to an interlayer suitable for use in solid-state batteries. Such interlayers generally include: (1) a plurality of carbon nanomaterials; and (2) a plurality of metallic nanoparticles uniformly dispersed on the carbon nanomaterials. The interlayers also include a percolating network operational for regulating ion flux through the interlayer. Additional embodiments pertain to solid- state batteries that include such interlayers, methods of forming such interlayers, and methods of forming solid-state batteries that include the interlayers.

IPC Classes  ?

• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• B22F 1/054 - Nanosized particles
• C01B 32/00 - CarbonCompounds thereof
• C01B 32/15 - Nanosized carbon materials
• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials

Abstract

Embodiments of the present disclosure pertain to a nucleic acid sequence that includes a promoter operatively linked to a heterologous nucleotide sequence encoding a cyclic GMP-AMP synthase (cGAS) polypeptide. The nucleotide sequence also encodes a stabilizing peptide, such as a small ubiquitin modifying protein (SUMO) polypeptide. Further embodiments of the present disclosure pertain to fusion proteins that include a cGAS polypeptide and a stabilizing peptide. Additional embodiments of the present disclosure pertain to a recombinant cell that expresses a heterologous nucleotide sequence of the present disclosure. Further embodiments of the present disclosure pertain to methods of utilizing the recombinant cells of the present disclosure to produce 2'3' cyclic GMP-AMP (2'3'-cGAMP).

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12P 19/36 - Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate

Abstract

Elbow erosion monitoring is of great significance to the safety of pipeline systems and maintenance personnel. A percussion method is used to monitor pipe erosion. Under different erosion degrees, the mass reduction of the elbow is measured by high-precision electronic scale and the residual thickness of the elbow is detected by telescoping gauge. Machine learning algorithm, the K- Nearest Neighbor and recurrent network method are employed to identify the different wall thickness level and erosion mass level.

IPC Classes  ?

• E21B 47/107 - Locating fluid leaks, intrusions or movements using acoustic means
• E21B 47/14 - Means for transmitting measuring-signals or control signals from the well to the surface, or from the surface to the well, e.g. for logging while drilling using acoustic waves
• G01H 9/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
• G01V 1/50 - Analysing data

Abstract

A method of forming a single-crystalline group-III-nitride (III-N) thick film includes epitaxially growing or depositing, on a silicon (Si) (111) substrate, one or more metallic interlayers or a superlattice structure including a plurality of pairs of a metallic layer and a semiconductor layer, epitaxially growing or depositing, on a top layer of the superlattice structure that is located opposite to the Si (111) substrate or on a top layer of the one or more metallic interlayers that is located opposite to the Si (111) substrate, the single-crystalline group-III-N thick film, epitaxially growing or depositing, on a top layer of the single-crystalline group-III-N thick film, a secondary substrate, removing the one or more metallic interlayers or the metallic layers from the superlattice structure to separate the Si (111) substrate, and transferring the single-crystalline group-III-N thick film on to the secondary substrate.

IPC Classes  ?

• C30B 23/02 - Epitaxial-layer growth
• C30B 29/38 - Nitrides
• C30B 25/18 - Epitaxial-layer growth characterised by the substrate
• C30B 29/68 - Crystals with laminate structure, e.g. "superlattices"

Abstract

Described to compositions and methods for recycling lithium-ion battery materials. More specifically, described herein to acid- and base-free compositions and methods for the recovery of lithium and other valuable materials such as Ni, Co, Mn, Cu, Al, graphite, etc. from lithium-containing battery materials for subsequent purification and reuse. Certain methods described herein for recovering lithium from a lithium-ion battery comprise isolating a bulk material from a cathode or the cathode and an anode of a lithium-ion battery, the bulk material comprising lithium, reacting the bulk material with a persulfate compound to form lithium sulfate or a hydrate thereof, and recovering the lithium sulfate or the hydrate thereof.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• C22B 26/12 - Obtaining lithium
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof

Abstract

The invention refers to a computer-implemented method for calibrating a pair of digital elevation maps (DEMI, DEM2), where the digital elevation maps (DEMI, DEM2) of the pair have been acquired from measurements of a first radar sensor equipment (RE1) and indicate for different time points the height of a predetermined terrain (TR) on a surface of a celestial body, wherein the method processes a time series (ts) of SAR images (TSIM) of the predetermined terrain (TR) acquired from measurements of a second radar sensor equipment (RE2), the method comprising the following steps: a) determining candidate calibration points (ccp) from the time series (ts) of SAR images (TSIM) based on dispersion measures (D) of respective pixel positions within the SAR images (TSIM) of the time series (ts); b) identifying pixel positions as calibration points (cp) within the digital elevation maps (DM1, DM2) of the pair based on the candidate calibration points (ccp); c) determining height value differences (Δ) between the digital elevation maps (DEMI, DEM2) of the pair at the calibration points (cp); d) fitting a two-dimensional curve (CS) to the height value differences (A) at the calibration points (cp), the two-dimensional curve (CS) describing the height value differences (Δ) over the pixel positions representing corresponding points within the predetermined terrain (TR); e) correcting the height values (hvl, hv2) of one digital elevation map (DEMI, DEM2) of the pair by the height value differences (Δ) of the two-dimensional curve (CS).

IPC Classes  ?

• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
• G01S 13/87 - Combinations of radar systems, e.g. primary radar and secondary radar
• G01S 13/90 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging using synthetic aperture techniques

Abstract

In an embodiment, a deliberation experience system includes processor-executable instructions to: generate a deliberation platform including a plurality of forums and a manager dashboard to facilitate monitoring deliberation in each forum of the plurality of forums, the manager dashboard presented on a manager user device; receive a first input from the manager user device indicative of assigning a respective set of participant user devices to each forum and communicatively couple the respective set of participant user devices to each forum; receive a second input from the manager user device indicative of a selected issue guide of a plurality of issue guides, the selected issue guide including a plurality of discussion topics; and instruct a computer-automated moderator to initiate a guided discussion on each forum by progressing through each discussion topic of the selected issue guide in each forum and moderating discussion between participants on each forum.

IPC Classes  ?

• G06F 3/0486 - Drag-and-drop
• G06F 3/0482 - Interaction with lists of selectable items, e.g. menus

Abstract

Nanoparticles and nanonetworks formed of these nanoparticles are provided. Methods for forming such nanoparticles and nanonetworks are also provided, as well as uses of the nanoparticles and/or nanonetworks, including their use for drug delivery.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/365 - Lactones
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin

Abstract

A method for training a deep learning model includes training a first sorting deep learning model (DLM) using a training dataset to predict a presence of a target attribute in a first datapoint of the training dataset based on a presence of a first environmental attribute in the first datapoint, training a second sorting DLM using the training dataset to predict the absence of the target attribute in a second datapoint of the training dataset based on a presence of the first environmental attribute in the second datapoint, comparing a first difficulty score with a second difficulty score of the second sorting DLM, assigning the datapoints to a first environment in response to the first difficulty score being less than the second difficulty score, and assigning the datapoints to a second environment in response to the first difficulty score being greater than the second difficulty score.

IPC Classes  ?

• G06N 3/02 - Neural networks
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning

Abstract

A system for forecasting energy consumption by vehicles in a mixed-vehicle fleet. The system includes neural network(s) that generate a predictive function for vehicles in each of a number of classes (e.g., electric vehicles, hybrid vehicles, internal combustion vehicles, vehicle models, model years, etc.). To capture both the generalizable patterns that govern energy consumption across all vehicle classes and the features and relationships that are specific to each class, the neural network(s) include a multi-task learning model that includes shared layers for all of the classes of vehicles and a set of vehicle-specific layers for each class. In some of those embodiments, for example to predict to energy consumption of an additional class with limited data, the neural networks further include an inductive transfer learning model that includes the shared layers transferred from the multi-task learning model and vehicle-specific layers for the additional class.

IPC Classes  ?

• H04L 67/12 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
• B60L 3/12 - Recording operating variables
• G06N 3/096 - Transfer learning
• G07C 5/08 - Registering or indicating performance data other than driving, working, idle, or waiting time, with or without registering driving, working, idle, or waiting time

Abstract

Loss of cardiomyocytes underlies most causes of heart failure, and normal repair processes are inadequate to deal with extensive myocardial damage. The inventors have identified mutations of the N-terminus of serum respose factor (SRF)'s MADS box, termed STEMINs, that block cardiac differentiation, but also powerfully activate the stem cell marker genes Nanog and Octomer 4, as well as cyclins, which promotes adult myocyte replication. SRF Stemin mutations are not cardiac-specific, and also propel mammalian fibroblasts into a proliferative state. Thus, STEMINs may be useful for regeneration of all tissue and organ types, by activating partial pluripotency programs and enhacing repair by increased cell replication. Following withdrawal of STEMINs, the cells then return to normal cell identity.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C12N 15/86 - Viral vectors

Abstract

A corrective lens for correcting of myopia of an eye of a patient includes an internal diffractive region and a concave spherical surface. The corrective lens controls longitudinal chromatic aberration by changing a longitudinal focus of blue and red light relative to a focal point of green light.

IPC Classes  ?

• G02C 7/06 - LensesLens systems bifocalLensesLens systems multifocal
• A61F 2/16 - Intraocular lenses
• B29D 11/00 - Producing optical elements, e.g. lenses or prisms
• G02B 5/18 - Diffracting gratings

Abstract

A nail trimming assistive device includes a support frame having a brace portion defining a brace receptacle for receiving a user's hand and a support portion defining a support receptacle for receiving a separate support member. The nail trimming assistive device additionally includes a clamping member configured to apply a clamping force to the support member when received in the support receptacle, an actuator to displace the clamping member along a clamping axis into and out of engagement with the support member, and a flexible retaining member having an open configuration in which a free end thereof is spaced from the support frame, and a closed configuration in which the free end is coupled to the support frame.

IPC Classes  ?

• A45D 29/22 - Finger-supports
• A45D 29/02 - Nail clippers or cutters
• A45D 29/00 - Manicuring or pedicuring implements

Abstract

A method of preparing a water electrolysis catalyst comprising subjecting at least a portion of a substrate to a temperature of from about 400 °C to about 1500 °C for a time period of from about 5 seconds to about 30 minutes to form a heat-treated substrate; contacting the heat-treated substrate with a fluid comprising a transition metal salt under conditions suitable for formation of the water electrolysis catalyst wherein the catalyst has an overpotential ranging from about 100 mV to about 1000 mV in a water electrolysis reaction at a current density of 500 mA/cm2.

IPC Classes  ?

• B01J 37/08 - Heat treatment
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/051 - Electrodes formed of electrocatalysts on a substrate or carrier
• B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
• B01J 23/745 - Iron
• B01J 23/755 - Nickel

Abstract

This invention relates to nickel catalysts with alkali ions for homopolymerization and copolymerization.

IPC Classes  ?

• C08F 4/70 - Iron group metals, platinum group metals, or compounds thereof
• C08F 2/06 - Organic solvent
• C08F 10/02 - Ethene
• C08F 210/02 - Ethene

Abstract

The present invention relates to cultivating fungus and to materials and/or methods for producing, growing, and/or cultivating fungus.

IPC Classes  ?

• A01G 18/00 - Cultivation of mushrooms
• C12N 1/14 - Fungi Culture media therefor
• A01N 65/03 - Algae
• A01G 33/00 - Cultivation of seaweed

Abstract

A method of manufacturing a polymer electrolyte membrane comprising solubilizing an ionomer in a first solvent to produce a solubilized ionomer; thermally-treating the solubilized ionomer to produce a thermally-treated solubilized ionomer;solubilizing a structuring agent in a second solvent to form a solubilized structuring agent; and contacting the thermally-treated solubilized ionomer with the solubilized structuring agent to form a composite solution; and casting the composite solution onto a substrate to form a cast membrane. An electrochemical device comprising a polymer membrane wherein the polymer membrane comprises a sulfonic acid containing-polymer and a structuring agent characterized by an extent of entanglement of from about 5% to about 25%.

IPC Classes  ?

• H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers
• H01M 4/88 - Processes of manufacture
• H01M 8/1032 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having sulfur, e.g. sulfonated-polyethersulfones [S-PES]
• H01M 8/1046 - Mixtures of at least one polymer and at least one additive

Abstract

A corrective lens for controlling myopia of an eye of a patient. The corrective lens includes a central region at least partially preventing light transmission, and a light transmissive region formed at least through a center area of the central region.

IPC Classes  ?

• G02C 7/16 - Shades, shieldsObturators, e.g. with pinhole, with slot
• G02C 7/04 - Contact lenses for the eyes

Abstract

The present inventions concerns a method for identifying at least one biological characteristic of a complex molecular structure, the method comprising producing an interaction network representation of the complex molecular structure from a structural file, wherein said representation comprises nodes connected by edges, and using the interaction network representation to identify said at least one biological characteristic of the complex molecular structure. The present inventions also concerns a computer program comprising software instructions which, when executed by a computer, implement a method according to the invention.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G16C 20/50 - Molecular design, e.g. of drugs
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Abstract

This invention relates to contorted polyamide polymers. This invention also relates to contorted polyamide membranes, methods of making the contorted polyamide membranes, and methods of using the contorted polyamide membranes.

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• C07D 487/08 - Bridged systems
• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors

Abstract

Peptoid compositions targeting RAS proteins and methods of treatment of cancers using these peptoid compositions are described here. Also provided are fatty acid conjugated peptoid compositions that interact with KRAS, HRAS, or NRAS proteins. Certain peptoid compositions inhibit function of a KRAS protein in a cancer cell. The KRAS protein can be a mutant or wild type KRAS protein. The peptoid composition can be administered along with a MEK inhibitor or an ERK inhibitor.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• C07K 14/785 - Alveolar surfactant peptidesPulmonary surfactant peptides

Abstract

An imaging system for capturing images of the periphery of an eye of a patient is disclosed. An optical signal source provides an optical source light. A microlens array is placed at the pupil conjugate of the patient. An image sensor receives focused light from the microlens array. A horizontal scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in the horizontal plane to the eye. A vertical scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in a vertical plane to the eye. A controller controls the horizontal scan system and the vertical scan system. The horizontal scan system captures images in a horizontal scan. The vertical scan system captures images in a vertical scan. Both the horizontal scan system and the vertical scan system are activated to capture images in a diagonal scan.

IPC Classes  ?

• A61B 3/14 - Arrangements specially adapted for eye photography
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

Abstract

A centrifugal mixing system includes an outer shell having an inlet end and an outlet end, an inner cylinder rotatably positioned in the outer shell including a heterogenous pattern including one or more untreated surfaces and one or more hydrophobic surfaces where the one or more hydrophobic surfaces, and a motor coupled to the inner cylinder and configured to rotate the inner cylinder within and relative to the outer shell about a rotational axis to mix a fluid received from the fluid inlet and disposed in an annulus formed between the inner cylinder and the outer shell in response to rotation of the inner cylinder about the rotational axis.

IPC Classes  ?

• B01F 27/053 - Stirrers characterised by their elements, materials or mechanical properties characterised by their materials
• B01F 27/111 - Centrifugal stirrers, i.e. stirrers with radial outletsStirrers of the turbine type, e.g. with means to guide the flow
• B01F 27/94 - Mixers with rotary stirring devices in fixed receptaclesKneaders with stirrers rotating about a substantially vertical axis with rotary cylinders or cones

Abstract

A method, computer program product and system for ensuring a smooth user experience in a multi-user augmented reality system. A computing device ("master") shares a quadtree data structure of an image with a virtual 3D object with another computing device ("slave"), which inputs the quadtree data structure into a machine learning (ML) model to obtain ML results which is used by the slave to render an image of the virtual 3D object in the field of view of the slave, which may experience slight offset. The slave transforms the rendered image into a quadtree data structure, which is shared with the master along with the ML results. The master then inputs the received information into its ML model. The ML results from the ML model may include correction values, which may be applied to the image previously rendered by the master. This iterative process continues until corrections are not necessary.

IPC Classes  ?

• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 7/10 - SegmentationEdge detection
• G06T 7/149 - SegmentationEdge detection involving deformable models, e.g. active contour models
• G06N 20/00 - Machine learning
• G06T 13/00 - Animation

Abstract

The present disclosure pertains to compositions suitable for use in differentiating cardiac progenitor cells to cells that resemble cardiac Purkinje cells. Additional embodiments pertain to methods of generating such differentiated cardiac cells by exposing cardiac progenitor cells to the compositions. The present disclosure also pertains to methods of treating or preventing a cardiovascular disease in a subject by administering the compositions or differentiated cardiac cells to the subject. Further embodiments pertain to methods of generating a cardiac tissue by exposing cardiac progenitor cells to a composition of the present disclosure and associating the cardiac progenitor cells with a tissue scaffold. The present disclosure also pertains to the use of the differentiated cardiac progenitor cells to assess the efficacy of one or more compounds in the treatment or prevention of a cardiovascular disease. The present disclosure also pertains to the differentiated cardiac cells and cardiac tissues that include them.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

Embodiments of the present disclosure pertains to one or more novel peptoids, derivatives thereof, multimers thereof, and combinations thereof. The peptoids may be suitable for use in treating or preventing a cancer in a subject, detecting a cancer in a subject, or as research and development tools. Further embodiments pertain to methods of inhibiting the growth of cancer cells by exposing the cancer cells to the peptoids. Additional embodiments of the present disclosure pertain to methods of treating or preventing a cancer in a subject by administering the peptoids to the subject. Further embodiments pertain to methods of detecting cancer in a subject by exposing cells susceptible of being cancerous to the peptoids, detecting the presence or absence of vimentin associated with cells susceptible of being cancerous, and correlating the presence or absence of the vimentin to the presence or absence of the cancer in the subject.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

A system and method to detect cognitive impairment is disclosed. A head mounted sensor is operable to be worn by a user. The head mounted sensor includes an optical sensor for collecting an optical response from a region of interest in the brain of the user. A user input interface receives a user test input from a test device executing a stimulation test to the user. A controller is coupled to the sensor device and the user input interface. The controller collects optical response data from the optical sensor and test input data from the test device. The controller determines a hemoglobin level in the region of interest based on the optical response data. The determined hemoglobin level in the region of interest is correlated with the user test input in response to the stimulation test. Brain activity is evaluated based on the determined hemoglobin level.

IPC Classes  ?

• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06V 40/00 - Recognition of biometric, human-related or animal-related patterns in image or video data
• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics

Abstract

Mycobacterium tuberculosisMycobacterium tuberculosis. Additional embodiments of the present disclosure pertain to methods of treating or preventing tuberculosis in a subject by administering a composition of the present disclosure to the subject.

IPC Classes  ?

• A61K 39/04 - Mycobacterium, e.g. Mycobacterium tuberculosis
• A61K 39/116 - Polyvalent bacterial antigens
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 31/06 - Antibacterial agents for tuberculosis
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61P 37/04 - Immunostimulants

Abstract

A hydrogen storage device comprising (i) hydrogen gas and (ii) a host framework material. A hydrogen discharge device comprising (i) hydrogen gas and (ii) a host framework material. A method of storing hydrogen comprising introducing hydrogen gas to a host framework material comprising a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof under conditions suitable for the formation of hydrogen gas hydrates. A battery comprising a host framework material comprising hydrogen gas hydrates wherein the host framework material comprises a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof.

IPC Classes  ?

• C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
• H01M 10/34 - Gastight accumulators

Abstract

Embodiments of the present disclosure pertain to methods of separating nucleic acids from a sample by applying the sample to a fiber-based electrophoresis medium and generating an electric field across the fiber-based electrophoresis medium, where the generated electric field induces migration and separation of the nucleic acids across the fiber-based electrophoresis medium. The methods of the present disclosure may also include a step of detecting one or more of the separated nucleic acids on the fiber-based electrophoresis medium, diagnosing a disease or condition based on the detecting, and implementing a treatment decision based on the diagnosis. Additional embodiments of the present disclosure pertain to nucleic acid separation systems for separating nucleic acids and methods of making them.

IPC Classes  ?

• C12Q 1/6858 - Allele-specific amplification
• C12Q 1/686 - Polymerase chain reaction [PCR]
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

This invention relates to hydrogen storage materials, and to devices, systems and methods utilizing the hydrogen storage materials.

IPC Classes  ?

• C01B 39/24 - Type Y
• C01B 3/00 - HydrogenGaseous mixtures containing hydrogenSeparation of hydrogen from mixtures containing itPurification of hydrogen
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

PRPH2PRPH2-associatcd inherited retinal disorders. Preferred embodiments for the downregulation of rhodopsin utilize antisense oligonucleotides (ASO) that lead to producing less rhodopsin such as by degradation of rhodopsin mRNA.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Embodiments of the present disclosure pertain to a housing unit that includes: (1) a container with a top area and a base area; (2) a cavity within the container between the top area and the base area and configured to house an object; and (3) an opening on the top area, where the opening includes (a) a plurality of shutter elements surrounding the opening, and (b) an actuation system operatively connected to the shutter elements and configured to adjust the positions of the shutter elements relative to the opening. Additional embodiments of the present disclosure pertain to methods of altering objects by placing an object in a cavity of a housing unit through its opening and then altering the object in the cavity. The housing units and methods of the present disclosure may be utilized to alter objects for various purposes, such as vascular anastomosis training.

IPC Classes  ?

• G09B 23/32 - Anatomical models with moving parts
• G09B 23/34 - Anatomical models with removable parts

Abstract

Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems

Abstract

Embodiments of the present disclosure pertain to methods of enriching one or more molecules in a medium by applying a spatially non-uniform alternating current electric field (AC electric field) to the medium, where the AC electric field enriches the molecules in the medium through initiating electromigration of the molecules. The methods may also include steps of sensing and/or purifying the molecules. Additional embodiments of the present disclosure pertain to systems for enriching one or more molecules, where the system includes a housing unit operational to house a medium that includes the molecules to be enriched, and an electrode operational to be electrically connected to the medium and apply an AC electric field to the medium.

IPC Classes  ?

• B01D 59/42 - Separation by electrochemical methods by electromigrationSeparation by electrochemical methods by electrophoresis
• G01N 1/40 - Concentrating samples

Abstract

This invention relates to materials and methods for iodine capture from a variety of sources and media, and at water/organic solvent interfaces.

IPC Classes  ?

• C07C 251/86 - Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• C02F 1/26 - Treatment of water, waste water, or sewage by extraction
• C07C 249/16 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
• C07D 213/76 - Nitrogen atoms to which a second hetero atom is attached
• C30B 29/54 - Organic compounds
• G21F 9/02 - Treating gases

Abstract

Organic semiconductor microelectronic devices (OSMDs) can be fabricated through direct 3D printing using a gel-pen technique. The technique utilizes in situ electrochemical deposition of the meniscus provided by a wet hydrogel cartridge at the electrode interface. Bioactive proteins such as laminin, fibronectin and. glucose oxidase can be incorporated in the gel and entrapped within the OSMDs.

IPC Classes  ?

• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
• H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing

Abstract

In an embodiment, the present disclosure pertains to electric field generators that include a signal generator electrically connected to a power amplifier, a impedance matching circuit electrically connected to the power amplifier, and a power divider electrically connected to the impedance matching circuit and to at least one of a first wall, a second wall, a third wall, a fourth wall, or a base area. In an additional embodiment, the present disclosure pertains to method of determining radio frequency (RF)-induced heating on a medical device utilizing an electric field generator of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making electric field generators for testing a medical device.

IPC Classes  ?

• G01R 33/28 - Details of apparatus provided for in groups
• G01N 25/00 - Investigating or analysing materials by the use of thermal means
• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
• H03F 3/20 - Power amplifiers, e.g. Class B amplifiers, Class C amplifiers

Abstract

An ultra-thin film superconducting tape and method for fabricating same is disclosed. Embodiments are directed to a superconducting tape being fabricated by processes which include removing a portion of the superconducting tape's substrate subsequent the substrate's initial formation, whereby a thickness of the superconducting tape is reduced to 15-80 μm.

IPC Classes  ?

• H10N 60/01 - Manufacture or treatment
• H10N 60/20 - Permanent superconducting devices
• H10N 60/85 - Superconducting active materials

Abstract

This invention relates to materials for electrodes, to materials for lithium-ion batteries, and to materials for lithium-ion storage.

IPC Classes  ?

• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• C07C 49/792 - Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.

IPC Classes  ?

• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

A template for the production of nanowires or nanostructures includes a substrate, a first neutral layer disposed on the substrate, a vertically aligned lamellar block copolymer film layer disposed on the first neutral layer, and a second neutral layer disposed on the block copolymer film layer. The vertically aligned lamellar block copolymer film layer can be formed from a block copolymer via Shear-Directed Self-Assembly (SDSA) using a cold zone annealing soft shear (CZA-SS) methodology.

IPC Classes  ?

• C08F 220/10 - Esters
• C08F 220/02 - Monocarboxylic acids having less than ten carbon atomsDerivatives thereof
• C08F 220/06 - Acrylic acidMethacrylic acidMetal salts or ammonium salts thereof
• C08L 33/04 - Homopolymers or copolymers of esters
• C08F 287/00 - Macromolecular compounds obtained by polymerising monomers on to block polymers
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids

Abstract

A system for tracking an eye of a user includes one or more piezoelectric sensors positionable on the face of the user, and an eye tracking computer system in signal communication with the one or more piezoelectric sensors so as to receive signals from the one or more piezoelectric sensors, wherein the computer system is configured to detect movement in at least one direction of the eye of the user based on the signals received by the computer system from the one or more piezoelectric sensors when the one or more piezoelectric sensors are positioned on the face of the user in one or more locations each spaced from the eyelids of the user.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A method for reducing the metal content in a water source includes dissolving an amount of a solubilizing anion in a low grade water comprising one or more cations under conditions suitable to formed a suspension comprising insoluble solubilizing anion-cation complexes wherein the anion comprises; and separating the insoluble solubilizing anion-cation complexes from the suspension to obtain a higher grade water having a metal content reduced by from about 50% to about 100%.

IPC Classes  ?

• C02F 1/00 - Treatment of water, waste water, or sewage
• C02F 11/14 - Treatment of sludgeDevices therefor by de-watering, drying or thickening with addition of chemical agents
• C02F 1/28 - Treatment of water, waste water, or sewage by sorption

Abstract

This invention relates to catalysts for microwave reforming of hydrocarbons, systems incorporing the catalysts for microwave reforming of hydrocarbons, and methods for using the catalysts for microwave reforming of hydrocarbons.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/19 -
• B01J 35/30 - Catalysts, in general, characterised by their form or physical properties characterised by their physical properties

Abstract

This invention relates to an mRNA-based vaccine composition for strains of herpes simplex virus (HSV), such as herpes simplex virus-2 (HSV-2). The mRNA vaccine composition comprises a combination of herpesvirus glycoprotein D (gD) and gB-pf mRNA, either alone or in combination with gE and/or gC mRNA.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses

Abstract

Described herein are polymers comprising a terminus having a structure according to formula (1): wherein R is a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic.

IPC Classes  ?

• C08F 4/70 - Iron group metals, platinum group metals, or compounds thereof
• C08F 2/38 - Polymerisation using regulators, e.g. chain terminating agents
• C08F 10/02 - Ethene
• C08F 10/14 - Monomers containing five or more carbon atoms
• C08F 212/08 - Styrene
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule

Abstract

An underwater device with buoyancy control as well as a method and computer program product for buoyancy control of an underwater device. Upon receiving an estimate of a current depth of the underwater device, a calculation is performed to determine the difference between the estimated current depth of the underwater device and the target. Based on such a difference exceeding a threshold value, an input to fuel cells in the underwater device is generated to either produce a net gas rate which is accumulated by flexible membranes to gain a volume which generates a positive buoyancy force or to intake gasses which generates a negative buoyancy force. The positive buoyancy force and the negative buoyancy force are used to control the depth of the underwater device to reach a target depth from the current depth.

IPC Classes  ?

• B63G 8/00 - Underwater vessels, e.g. submarines
• B63G 8/22 - Adjustment of buoyancy by water ballastingEmptying equipment for ballast tanks
• B63G 8/24 - Automatic depth adjustmentSafety equipment for increasing buoyancy, e.g. detachable ballast, floating bodies
• H01M 8/00 - Fuel cellsManufacture thereof
• F03B 13/00 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates
• B63B 22/20 - Ballast means
• B63B 22/18 - Buoys having means to control attitude or position, e.g. reaction surfaces or tether