Loss of cardiomyocytes underlies most causes of heart failure, and normal repair processes are inadequate to deal with extensive myocardial damage. The inventors have identified mutations of the N-terminus of serum respose factor (SRF)'s MADS box, termed STEMINs, that block cardiac differentiation, but also powerfully activate the stem cell marker genes Nanog and Octomer 4, as well as cyclins, which promotes adult myocyte replication. SRF Stemin mutations are not cardiac-specific, and also propel mammalian fibroblasts into a proliferative state. Thus, STEMINs may be useful for regeneration of all tissue and organ types, by activating partial pluripotency programs and enhacing repair by increased cell replication. Following withdrawal of STEMINs, the cells then return to normal cell identity.
A61K 38/17 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A nail trimming assistive device includes a support frame having a brace portion defining a brace receptacle for receiving a user's hand and a support portion defining a support receptacle for receiving a separate support member. The nail trimming assistive device additionally includes a clamping member configured to apply a clamping force to the support member when received in the support receptacle, an actuator to displace the clamping member along a clamping axis into and out of engagement with the support member, and a flexible retaining member having an open configuration in which a free end thereof is spaced from the support frame, and a closed configuration in which the free end is coupled to the support frame.
3.
MYOPIA CONTROL USING CORRECTED LONGITUDINAL CHROMATIC ABERRATION
A corrective lens for correcting of myopia of an eye of a patient includes an internal diffractive region and a concave spherical surface. The corrective lens controls longitudinal chromatic aberration by changing a longitudinal focus of blue and red light relative to a focal point of green light.
A method of preparing a water electrolysis catalyst comprising subjecting at least a portion of a substrate to a temperature of from about 400 °C to about 1500 °C for a time period of from about 5 seconds to about 30 minutes to form a heat-treated substrate; contacting the heat-treated substrate with a fluid comprising a transition metal salt under conditions suitable for formation of the water electrolysis catalyst wherein the catalyst has an overpotential ranging from about 100 mV to about 1000 mV in a water electrolysis reaction at a current density of 500 mA/cm2.
5.
NICKEL CATALYSTS WITH SINGLE ALKALI IONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION
A method of manufacturing a polymer electrolyte membrane comprising solubilizing an ionomer in a first solvent to produce a solubilized ionomer; thermally-treating the solubilized ionomer to produce a thermally-treated solubilized ionomer;solubilizing a structuring agent in a second solvent to form a solubilized structuring agent; and contacting the thermally-treated solubilized ionomer with the solubilized structuring agent to form a composite solution; and casting the composite solution onto a substrate to form a cast membrane. An electrochemical device comprising a polymer membrane wherein the polymer membrane comprises a sulfonic acid containing-polymer and a structuring agent characterized by an extent of entanglement of from about 5% to about 25%.
H01M 8/1081 - Matériaux d’électrolyte polymère caractérisés par le procédé de fabrication à partir de solutions, de dispersions ou de suspensions de polymères uniquement
H01M 8/1032 - Matériaux d’électrolyte polymère caractérisés par la structure chimique de la chaîne principale du polymère conducteur ionique comprenant du soufre, p.ex. des polyéthersulfones sulfonés [S-PES]
H01M 8/1046 - Mélanges d’au moins un polymère et d’au moins un additif
8.
CORRECTIVE LENS AND METHOD FOR CONTROLLING MYOPIA EFFECTS OR EYE ABERRATIONS
A corrective lens for controlling myopia of an eye of a patient. The corrective lens includes a central region at least partially preventing light transmission, and a light transmissive region formed at least through a center area of the central region.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE PARIS-SACLAY (France)
UNIVERSITY OF HOUSTON (USA)
Inventeur(s)
Fox, George E
Tirumalai, Madhan
Tran, Quyen D
Calvet, Laurie
Abrégé
The present inventions concerns a method for identifying at least one biological characteristic of a complex molecular structure, the method comprising producing an interaction network representation of the complex molecular structure from a structural file, wherein said representation comprises nodes connected by edges, and using the interaction network representation to identify said at least one biological characteristic of the complex molecular structure. The present inventions also concerns a computer program comprising software instructions which, when executed by a computer, implement a method according to the invention.
G16B 15/30 - Ciblage de médicament à l’aide de données structurelles; Prévision d’amarrage ou de liaison moléculaire
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16C 20/50 - Conception moléculaire, p.ex. de médicaments
G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p.ex. relations structurelles ou fonctionnelles ou alignement de structures
10.
CONTORTED POLYAMIDE MEMBRANES AND METHODS OF USE THEREOF
This invention relates to contorted polyamide polymers. This invention also relates to contorted polyamide membranes, methods of making the contorted polyamide membranes, and methods of using the contorted polyamide membranes.
B01D 71/62 - Polycondensats ayant des hétérocycles contenant de l'azote dans la chaîne principale
C08G 69/26 - Polyamides dérivés, soit des acides amino-carboxyliques, soit de polyamines et d'acides polycarboxyliques dérivés de polyamines et d'acides polycarboxyliques
11.
PEPTOID COMPOSITIONS TARGETING RAS PROTEINS AND METHODS OF TREATMENT OF CANCER USING THE SAME
Peptoid compositions targeting RAS proteins and methods of treatment of cancers using these peptoid compositions are described here. Also provided are fatty acid conjugated peptoid compositions that interact with KRAS, HRAS, or NRAS proteins. Certain peptoid compositions inhibit function of a KRAS protein in a cancer cell. The KRAS protein can be a mutant or wild type KRAS protein. The peptoid composition can be administered along with a MEK inhibitor or an ERK inhibitor.
An imaging system for capturing images of the periphery of an eye of a patient is disclosed. An optical signal source provides an optical source light. A microlens array is placed at the pupil conjugate of the patient. An image sensor receives focused light from the microlens array. A horizontal scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in the horizontal plane to the eye. A vertical scan system is coupled to the microlens array and the image sensor to capture wavefront images in a scan range in a vertical plane to the eye. A controller controls the horizontal scan system and the vertical scan system. The horizontal scan system captures images in a horizontal scan. The vertical scan system captures images in a vertical scan. Both the horizontal scan system and the vertical scan system are activated to capture images in a diagonal scan.
A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil
A61B 3/12 - Appareils pour l'examen optique des yeux; Appareils pour l'examen clinique des yeux du type à mesure objective, c. à d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour examiner le fond de l'œil, p.ex. ophtalmoscopes
A centrifugal mixing system includes an outer shell having an inlet end and an outlet end, an inner cylinder rotatably positioned in the outer shell including a heterogenous pattern including one or more untreated surfaces and one or more hydrophobic surfaces where the one or more hydrophobic surfaces, and a motor coupled to the inner cylinder and configured to rotate the inner cylinder within and relative to the outer shell about a rotational axis to mix a fluid received from the fluid inlet and disposed in an annulus formed between the inner cylinder and the outer shell in response to rotation of the inner cylinder about the rotational axis.
B01F 27/053 - Agitateurs caractérisés par leurs éléments, leurs matériaux ou leurs propriétés mécaniques caractérisés par leurs matériaux
B01F 27/111 - Agitateurs centrifuges, c. à d. agitateurs à sortie radiale; Agitateurs de type turbine, p.ex. avec des moyens pour guider le flux
B01F 27/94 - Mélangeurs à agitateurs tournant dans des récipients fixes; Pétrins avec des agitateurs tournant autour d'un axe sensiblement vertical avec des cylindres ou des cônes rotatifs
14.
ENSURING A SMOOTH USER EXPERIENCE IN A MULTI-USER AUGMENTED REALITY SYSTEM
A method, computer program product and system for ensuring a smooth user experience in a multi-user augmented reality system. A computing device ("master") shares a quadtree data structure of an image with a virtual 3D object with another computing device ("slave"), which inputs the quadtree data structure into a machine learning (ML) model to obtain ML results which is used by the slave to render an image of the virtual 3D object in the field of view of the slave, which may experience slight offset. The slave transforms the rendered image into a quadtree data structure, which is shared with the master along with the ML results. The master then inputs the received information into its ML model. The ML results from the ML model may include correction values, which may be applied to the image previously rendered by the master. This iterative process continues until corrections are not necessary.
The present disclosure pertains to compositions suitable for use in differentiating cardiac progenitor cells to cells that resemble cardiac Purkinje cells. Additional embodiments pertain to methods of generating such differentiated cardiac cells by exposing cardiac progenitor cells to the compositions. The present disclosure also pertains to methods of treating or preventing a cardiovascular disease in a subject by administering the compositions or differentiated cardiac cells to the subject. Further embodiments pertain to methods of generating a cardiac tissue by exposing cardiac progenitor cells to a composition of the present disclosure and associating the cardiac progenitor cells with a tissue scaffold. The present disclosure also pertains to the use of the differentiated cardiac progenitor cells to assess the efficacy of one or more compounds in the treatment or prevention of a cardiovascular disease. The present disclosure also pertains to the differentiated cardiac cells and cardiac tissues that include them.
Embodiments of the present disclosure pertains to one or more novel peptoids, derivatives thereof, multimers thereof, and combinations thereof. The peptoids may be suitable for use in treating or preventing a cancer in a subject, detecting a cancer in a subject, or as research and development tools. Further embodiments pertain to methods of inhibiting the growth of cancer cells by exposing the cancer cells to the peptoids. Additional embodiments of the present disclosure pertain to methods of treating or preventing a cancer in a subject by administering the peptoids to the subject. Further embodiments pertain to methods of detecting cancer in a subject by exposing cells susceptible of being cancerous to the peptoids, detecting the presence or absence of vimentin associated with cells susceptible of being cancerous, and correlating the presence or absence of the vimentin to the presence or absence of the cancer in the subject.
A system and method to detect cognitive impairment is disclosed. A head mounted sensor is operable to be worn by a user. The head mounted sensor includes an optical sensor for collecting an optical response from a region of interest in the brain of the user. A user input interface receives a user test input from a test device executing a stimulation test to the user. A controller is coupled to the sensor device and the user input interface. The controller collects optical response data from the optical sensor and test input data from the test device. The controller determines a hemoglobin level in the region of interest based on the optical response data. The determined hemoglobin level in the region of interest is correlated with the user test input in response to the stimulation test. Brain activity is evaluated based on the determined hemoglobin level.
Mycobacterium tuberculosisMycobacterium tuberculosis. Additional embodiments of the present disclosure pertain to methods of treating or preventing tuberculosis in a subject by administering a composition of the present disclosure to the subject.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p.ex. émulsion, particule, complexe d’inclusion, stent ou kit
A hydrogen storage device comprising (i) hydrogen gas and (ii) a host framework material. A hydrogen discharge device comprising (i) hydrogen gas and (ii) a host framework material. A method of storing hydrogen comprising introducing hydrogen gas to a host framework material comprising a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof under conditions suitable for the formation of hydrogen gas hydrates. A battery comprising a host framework material comprising hydrogen gas hydrates wherein the host framework material comprises a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof.
C01B 3/00 - Hydrogène; Mélanges gazeux contenant de l'hydrogène; Séparation de l'hydrogène à partir de mélanges en contenant; Purification de l'hydrogène
Embodiments of the present disclosure pertain to methods of separating nucleic acids from a sample by applying the sample to a fiber-based electrophoresis medium and generating an electric field across the fiber-based electrophoresis medium, where the generated electric field induces migration and separation of the nucleic acids across the fiber-based electrophoresis medium. The methods of the present disclosure may also include a step of detecting one or more of the separated nucleic acids on the fiber-based electrophoresis medium, diagnosing a disease or condition based on the detecting, and implementing a treatment decision based on the diagnosis. Additional embodiments of the present disclosure pertain to nucleic acid separation systems for separating nucleic acids and methods of making them.
PRPH2PRPH2-associatcd inherited retinal disorders. Preferred embodiments for the downregulation of rhodopsin utilize antisense oligonucleotides (ASO) that lead to producing less rhodopsin such as by degradation of rhodopsin mRNA.
Embodiments of the present disclosure pertain to a housing unit that includes: (1) a container with a top area and a base area; (2) a cavity within the container between the top area and the base area and configured to house an object; and (3) an opening on the top area, where the opening includes (a) a plurality of shutter elements surrounding the opening, and (b) an actuation system operatively connected to the shutter elements and configured to adjust the positions of the shutter elements relative to the opening. Additional embodiments of the present disclosure pertain to methods of altering objects by placing an object in a cavity of a housing unit through its opening and then altering the object in the cavity. The housing units and methods of the present disclosure may be utilized to alter objects for various purposes, such as vascular anastomosis training.
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
Embodiments of the present disclosure pertain to methods of enriching one or more molecules in a medium by applying a spatially non-uniform alternating current electric field (AC electric field) to the medium, where the AC electric field enriches the molecules in the medium through initiating electromigration of the molecules. The methods may also include steps of sensing and/or purifying the molecules. Additional embodiments of the present disclosure pertain to systems for enriching one or more molecules, where the system includes a housing unit operational to house a medium that includes the molecules to be enriched, and an electrode operational to be electrically connected to the medium and apply an AC electric field to the medium.
C07C 251/86 - Hydrazones ayant des atomes de carbone, liés par des liaisons doubles, de groupes hydrazone liés à des atomes de carbone de cycles aromatiques à six chaînons
B01D 53/02 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse
C02F 1/26 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par extraction
C07C 249/16 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné d'hydrazones
C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome
Organic semiconductor microelectronic devices (OSMDs) can be fabricated through direct 3D printing using a gel-pen technique. The technique utilizes in situ electrochemical deposition of the meniscus provided by a wet hydrogel cartridge at the electrode interface. Bioactive proteins such as laminin, fibronectin and. glucose oxidase can be incorporated in the gel and entrapped within the OSMDs.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux
H10K 71/12 - Dépôt d'une matière active organique en utilisant un dépôt liquide, p. ex. revêtement par centrifugation
H10K 71/13 - Dépôt d'une matière active organique en utilisant un dépôt liquide, p. ex. revêtement par centrifugation en utilisant des techniques d'impression, p. ex. l’impression par jet d'encre ou la sérigraphie
An ultra-thin film superconducting tape and method for fabricating same is disclosed. Embodiments are directed to a superconducting tape being fabricated by processes which include removing a portion of the superconducting tape's substrate subsequent the substrate's initial formation, whereby a thickness of the superconducting tape is reduced to 15-80 μm.
In an embodiment, the present disclosure pertains to electric field generators that include a signal generator electrically connected to a power amplifier, a impedance matching circuit electrically connected to the power amplifier, and a power divider electrically connected to the impedance matching circuit and to at least one of a first wall, a second wall, a third wall, a fourth wall, or a base area. In an additional embodiment, the present disclosure pertains to method of determining radio frequency (RF)-induced heating on a medical device utilizing an electric field generator of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making electric field generators for testing a medical device.
G01R 33/28 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique - Détails des appareils prévus dans les groupes
G01N 25/00 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques
H03F 1/56 - Modifications des impédances d'entrée ou de sortie, non prévues ailleurs
H03F 3/20 - Amplificateurs de puissance, p.ex. amplificateurs de classe B, amplificateur de classe C
30.
CYCLOTETRABENZIL COMPOUNDS FOR ELECTROCHEMICAL LITHIUM-ION STORAGE
H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques
C07C 49/792 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons polycycliques contenant des cycles autres que des cycles aromatiques à six chaînons
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
31.
FORCE-MODULATED HYBRIDIZATION FOR VISUALIZING NUCLEIC ACID LENGTH AND FUNCTION
Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p.ex. séquençage par hybridation [SBH]
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissement; Dispositifs d'isolation thermique
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p.ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p.ex. transfert d’énergie de résonance
32.
HYBRID NANOSTRUCTURES AND METHODS OF MAKING THE SAME
A template for the production of nanowires or nanostructures includes a substrate, a first neutral layer disposed on the substrate, a vertically aligned lamellar block copolymer film layer disposed on the first neutral layer, and a second neutral layer disposed on the block copolymer film layer. The vertically aligned lamellar block copolymer film layer can be formed from a block copolymer via Shear-Directed Self-Assembly (SDSA) using a cold zone annealing soft shear (CZA-SS) methodology.
C08F 220/02 - Acides monocarboxyliques contenant moins de dix atomes de carbone; Leurs dérivés
C08F 220/06 - Acide acrylique; Acide méthacrylique; Leurs sels métalliques ou leurs sels d'ammonium
C08L 33/04 - Homopolymères ou copolymères des esters
C08F 287/00 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères séquencés
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
33.
SKIN-ATTACHABLE SENSOR SYSTEM AND METHOD FOR TRACKING EYE MOVEMENT AND POSITION
A system for tracking an eye of a user includes one or more piezoelectric sensors positionable on the face of the user, and an eye tracking computer system in signal communication with the one or more piezoelectric sensors so as to receive signals from the one or more piezoelectric sensors, wherein the computer system is configured to detect movement in at least one direction of the eye of the user based on the signals received by the computer system from the one or more piezoelectric sensors when the one or more piezoelectric sensors are positioned on the face of the user in one or more locations each spaced from the eyelids of the user.
A method for reducing the metal content in a water source includes dissolving an amount of a solubilizing anion in a low grade water comprising one or more cations under conditions suitable to formed a suspension comprising insoluble solubilizing anion-cation complexes wherein the anion comprises; and separating the insoluble solubilizing anion-cation complexes from the suspension to obtain a higher grade water having a metal content reduced by from about 50% to about 100%.
This invention relates to catalysts for microwave reforming of hydrocarbons, systems incorporing the catalysts for microwave reforming of hydrocarbons, and methods for using the catalysts for microwave reforming of hydrocarbons.
This invention relates to an mRNA-based vaccine composition for strains of herpes simplex virus (HSV), such as herpes simplex virus-2 (HSV-2). The mRNA vaccine composition comprises a combination of herpesvirus glycoprotein D (gD) and gB-pf mRNA, either alone or in combination with gE and/or gC mRNA.
Described herein are polymers comprising a terminus having a structure according to formula (1):
Described herein are polymers comprising a terminus having a structure according to formula (1):
Described herein are polymers comprising a terminus having a structure according to formula (1):
wherein R is a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic.
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
38.
CONTROLLING BUOYANCY OF UNDERWATER DEVICE USING FUEL CELLS AND PROPELLERS
An underwater device with buoyancy control as well as a method and computer program product for buoyancy control of an underwater device. Upon receiving an estimate of a current depth of the underwater device, a calculation is performed to determine the difference between the estimated current depth of the underwater device and the target. Based on such a difference exceeding a threshold value, an input to fuel cells in the underwater device is generated to either produce a net gas rate which is accumulated by flexible membranes to gain a volume which generates a positive buoyancy force or to intake gasses which generates a negative buoyancy force. The positive buoyancy force and the negative buoyancy force are used to control the depth of the underwater device to reach a target depth from the current depth.
B63G 8/22 - Réglage de la flottabilité par ballastage d'eau; Equipement pour vider les réservoirs de ballastage
B63G 8/24 - Réglage automatique de la profondeur; Dispositifs de sécurité pour augmenter la flottabilité, p.ex. ballast amovible, corps flottants
H01M 8/00 - PROCÉDÉS OU MOYENS POUR LA CONVERSION DIRECTE DE L'ÉNERGIE CHIMIQUE EN ÉNERGIE ÉLECTRIQUE, p.ex. BATTERIES Éléments à combustible; Leur fabrication
F03B 13/00 - Adaptations des "machines" ou machines motrices pour une utilisation particulière; Combinaisons des "machines" ou machines motrices avec les appareils entraînés ou qu'ils entraînent; Centrales électriques ou ensembles machine-appareil
Provided here are graphene composite materials and methods for producing a composite material containing magnetically aligned graphene nanosheets. One such method includes the steps of (a) dispersing graphene nanosheets and one or more monomers or polymers in a solution including a solvent to form a dilute dispersion; (b) evaporating the solvent from the dilute dispersion to form a concentrated dispersion; (c) applying a magnetic field to the dilute dispersion or the concentrated dispersion to align the GNS therein; and (d) curing the one or more monomers or polymers in the concentrated dispersion to produce the composite material.
A method, computer program product and system for improving the accuracy in artificial intelligence modeling in recognizing patterns and drawings conclusions in a manner that emulates human expertise. An arbitrary distribution of data is received. A free energy surface is constructed, in a memory, that encodes the arbitrary distribution of data, where correlations in the encoded data correspond to separate individual minima on the free energy surface. Information may then be retrieved from the free energy surface, such as via interrogation of the multiple energy functions used to encode the arbitrary distribution of data.
Interconnected zeolite nanosheets with a structural motif resembling self-pillared pentasil zeolites are synthesized through the use of MEL or MFI-type zeolites as crystalline seeds. The use of MEL- or MFI-type zeolites as crystalline seeds induces the spontaneous formation of pillared zeolites, thus avoiding, for the first time, the use of any organic or branching template for the crystallization of these hierarchical structures.
B01J 29/40 - Zéolites aluminosilicates cristallines; Leurs composés isomorphes du type pentasil, p.ex. types ZSM-5, ZSM-8 ou ZSM-11
B01J 35/40 - caractérisés par leurs dimensions, p. ex. granulométrie (catalyseurs sous forme de colloïdes B01J 35/23;taille des cristallites B01J 35/77)
A force application system for placement on and removal from an actuable latch with a robotic arm includes a driving pad configured for attachment to the actuable latch, a force application mechanism configured to increase an input force to an amplified output force that is applied by the force application mechanism to the driving pad, and a frame for engagement by the robotic arm.
Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
45.
NICKEL CATALYSTS WITH TWO METAL CATIONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION
A superconductor tape and method for manufacturing, measuring, monitoring, and controlling same are disclosed. Embodiments are directed to a superconductor tape which includes a superconductor film overlying a buffer layer which overlies a substrate. In one embodiment, the superconductor film is defined as having a c-axis lattice constant higher than 11.74 Angstroms. In another embodiment, the superconductor film comprises BaMO3, where M=Zr, Sn, Ta, Nb, Hf, or Ce, and which has a (101) peak of BaMO3 elongated along an axis that is between 60° to 90° from an axis of the (001) peaks of the superconductor film. These and other embodiments achieve well-aligned nanocolumnar defects and thus a high lift factor, which can result in superior critical current performance of the tape in, for example, high magnetic fields.
The present invention relates to a culture media system that is useful for the isolation and epigenetically stable propagation of normal stem cells in culture, wherein the stem cells are derived from stratified epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.
INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (USA)
Inventeur(s)
Degterev, Alexei
Duddupudi, Anantha Lakshmi
Cuny, Gregory
Shabahang, Shirin
Balachandran, Siddharth
Lee, Seungheon
Abrégé
Disclosed are substituted, heterocycle compounds. The substituted heterocycles disclosed herein are shown to be useful in activating necroptosis by activation of MLKL and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
Provided are improved oncolytic viruses with increased bystander cell killing and induced anti-tumor immunity. The oncolytic viruses include an oncolytic herpes virus backbone genetically modified to encode a tumor cell binding component and an immunoglobulin (Ig) binding component.
C07K 14/195 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries
C07K 14/485 - Facteur de croissance de l'épiderme (EGF) (urogastrone)
C07K 16/32 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des produits de traduction des oncogènes
Embodiments of the present disclosure pertain to methods and clinical decision support systems for distinguishing between a first and a second condition in a subject. Additional embodiments of the present disclosure pertain to computer-implemented methods of distinguishing between the first and the second condition in a subject. Further embodiments of the present disclosure pertain to computing devices that are operable to distinguish between the first and the second condition in a subject.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p.ex. pour des analyses d’échantillon de patient
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p.ex. pour analyser les cas antérieurs d’autres patients
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p.ex. de la grippe
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santé; TIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p.ex. pour la gestion du personnel hospitalier ou de salles d’opération
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p.ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p.ex. pour s’assurer de l’administration correcte aux patients
51.
ONCOLYTIC VIRUS FOR SYSTEMIC DELIVERY AND ENHANCED ANTI-TUMOR ACTIVITIES
This invention relates to oncolytic viruses which are more resistant to neutralization and phagocytosis by immune systems, and methods for their preparation and treatment of disorders and diseases (such as cancer) with them. Described herein is an oncolytic Herpes Simplex Virus Type 1 (HSV-1) or Herpes Simplex Virus Type 2 (HSV-2) treated in immune sera that contain a high level of anti-HSV antibodies. In one preferred embodiment, the oncolytic virus includes an extracellular CD47 domain inserted into the N-terminus of a glycoprotein in order to inhibit phagocyte activity. The oncolytic virus is suitable for systemic administration for the treatment of cancer.
A combination therapy for use in treatment of substance abuse disorders, including alcohol use disorder (AUD) and opioid use disorder (OUD), includes both mitragynine (MG) and naltrexone (NTX). NTX is understood to be a mu opioid antagonist that is expected to block MG's analgesic effects. However, combining MG and NTX therefore results in a unique, unexpected, and beneficial treatment that decreases alcohol self-administration to a greater extent than either alone.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/485 - Dérivés du morphinane, p.ex. morphine, codéine
A61P 25/30 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance
53.
Nickel catalysts with single metal cations for homopolymerization and copolymerization
A computer-implemented method for detecting or monitoring subsurface events includes receiving a data signal obtained from a subsurface region, and performing a continuous wavelet transform whereby a continuous wavelet is superimposed on the received data signal to determine one or more wavelet transform coefficients. The method further includes determining a signal energy from the one or more wavelet transform coefficients at a plurality of distinct scales, and detecting an occurrence of a subsurface event based on the signal energy.
G01V 1/36 - Exécution de corrections statiques ou dynamiques sur des enregistrements, p.ex. correction de l'étalement; Etablissement d'une corrélation entre signaux sismiques; Elimination des effets produits par un excès d'énergie
G01V 3/38 - Traitement de données, p.ex. pour l'analyse, pour l'interprétation ou pour la correction
E21B 49/00 - Test pour déterminer la nature des parois des trous de forage; Essais de couches; Procédés ou appareils pour prélever des échantillons du terrain ou de fluides en provenance des puits, spécialement adaptés au forage du sol ou aux puits
E21B 43/00 - Procédés ou dispositifs pour l'extraction de pétrole, de gaz, d'eau ou de matériaux solubles ou fusibles ou d'une suspension de matières minérales à partir de puits
55.
Nickel catalysts with single alkali ions for homopolymerization and copolymerization
Embodiments of the present disclosure pertain to modified cells that include a fusion protein of NPC intracellular cholesterol transporter 2 protein (NPC2) and another protein. Additional embodiments of the present disclosure pertain to methods of delivering a protein to a target cell by associating the target cell with a modified cell of the present disclosure, which includes a fusion protein of NPC2 and the protein to be delivered. Further embodiments of the present disclosure pertain to methods of treating or preventing a condition in a subject by administering to the subject a modified cell of the present disclosure. Additional embodiments of the present disclosure pertain to methods of making the modified cells of the present disclosure by introducing a fusion protein of the present disclosure to cells.
A system for image augmentation includes a processor and a memory. The memory includes instructions stored thereon, which when executed by the processor cause the system to access a first image and a second image, generate a path including points, perform a time-continuous transformation of a first distribution of pixels of the first image to a second distribution of pixels of the second image within a time interval along the path based on a mean-field game, and generate an augmented dataset based on the time-continuous transformation. The points start from the first image and end at the second image. The points include augmented images. The augmented images retain a shape of the first image and the second image.
A nuclear magnetic resonance (NMR) power supply system and method are disclosed. The architecture adopts a two-stage topology to reduce the required capacitance by over ten times, leading to a four-fold improvement in power density. The first stage is an isolated converter that only supplies average power, therefore input filter and transformer sizes can be reduced. The second stage is a fast response DC-DC converter followed by a RF transmitter to produce a pulsed RF signal, so that the mid-point voltage after the first stage can be allowed to droop considerably, leading to much smaller sized capacitors. These and other embodiments enforce the isolated converter to only transfer average power, which reduces the power rating and the volume of the system's transformer.
Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The at least one rRNA fragment includes at least one domain that associates with the tRNA fragments. The at least one rRNA fragment catalyzes the synthesis of the peptide through peptidyl transfer of the amino acids from the tRNA fragments independently of messenger RNA (mRNA) templates. Additionally, the peptidyl transfer occurs independently of proteins. Further embodiments of the present disclosure pertain to systems for synthesizing a peptide. Such systems include the rRNA fragments of the present disclosure and optionally a plurality of tRNA fragments.
Provided herein are compositions containing zileuton formulated for parenteral administration and/or extended use. Methods of treatment are directed to subjects who would benefit from extended use of zileuton to provide renal protective effects.
The present disclosure relates to analytic mapping of metagenomic and hydrocarbon footprints of geologic subzones. A plurality of DNA profiles are generated based on a set of distinct geological specimens from each well of a plurality of wells. BioGeo markers, BioGeo signatures and a BioGeo matrix are generated based on the plurality of DNA profiles.
An improved rechargeable battery may utilize materials that are entirely solid-state. The battery may utilize at least one organic active material for an electrode. The battery may utilize a cathode that comprises quinone(s). An electrolyte of the battery may be an ion-conducting inorganic compound. An anode of the battery may comprise an alkali metal. Further, a carbonyl group of the quinone(s) of the cathode may be reduced into a phenolate and coordinated to an alkali metal ion during discharge and vice versa during charging.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p.ex. batteries à insertion ou intercalation de lithium dans les deux électrodes; Batteries à l'ion lithium
H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p.ex. au magnésium ou à l'aluminium
The present invention provides a composition comprising a bimetallic catalyst complex comprising nickel and also, a 2+ cation, 3+ cation, 4+ cation, or 5+ cation. Also provided a method for catalyzing homopolymerization or copolymerization of an optionally substituted olefin, comprising: contacting an optionally substituted olefin with the bimetallic catalyst complex.
Provided here are apparatuses and methods for sample collection. One such sample collection apparatus includes a stencil having a first element, a second element, and a hinge connecting the first element and the second element. The first element has a top layer, an optional middle layer, and a bottom layer bonded together compositely with one or more design cutouts traversing the layers. The second element has an optional top layer and a bottom layer. The apparatus further includes a removable compression clip configured to secure an adsorbent media to the stencil. The apparatus may include an optional rivet to attach the removable compression clip to the stencil in a movable manner around the rivet. Also provided is a method for collecting a plurality of samples using the sample collection apparatus provided herein.
A61B 10/00 - Autres méthodes ou instruments pour le diagnostic, p.ex. pour le diagnostic de vaccination; Détermination du sexe; Détermination de la période d'ovulation; Instruments pour gratter la gorge
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
67.
NICKEL CATALYSTS WITH TWO ALKALI IONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION
The present invention provides a catalyst composition comprising at least four bimetallic catalyst complexes, wherein the at least four bimetallic catalyst complexes comprise nickel catalysts with alkali ions. Also provided a method for catalyzing homopolymerization or copolymerization of an optionally substituted olefin, comprising: contacting an optionally substituted olefin with the catalyst composition.
A soleus contraction measurement system includes a sensor configured to measure rotational movement when positioned on a user's foot with an X-axis oriented laterally across the user's foot, a Y-axis oriented parallel to the user's foot, a Z-axis orthogonal to the X-axis and the Y-axis, and a positive X-axis rotational movement corresponding to an increasing ankle angle, and a memory storing computer-executable instructions for controlling a processor to: measure an X-axis rotational movement, identify a positive X-axis rotational movement as a plantarflexion and a negative X-axis rotational movement as an ankle dorsiflexion, deem the plantarflexion a performed soleus contraction when the plantarflexion is immediately followed by the ankle dorsiflexion for two consecutive cycles of plantarflexion and ankle dorsiflexion, and cause performance information regarding the performed soleus contractions to be communicated.
A soleus contraction measurement system includes a sensor configured to measure rotational movement when positioned on a user's foot with an X-axis oriented laterally across the user's foot, a Y-axis oriented parallel to the user's foot, a Z-axis orthogonal to the X-axis and the Y-axis, and a positive X-axis rotational movement corresponding to an increasing ankle angle, and a memory storing computer-executable instructions for controlling a processor to: measure an X-axis rotational movement, identify a positive X-axis rotational movement as a plantarflexion and a negative X-axis rotational movement as an ankle dorsiflexion, deem the plantarflexion a performed soleus contraction when the plantarflexion is immediately followed by the ankle dorsiflexion for two consecutive cycles of plantarflexion and ankle dorsiflexion, and cause performance information regarding the performed soleus contractions to be communicated.
A biosensor may provide a magnetoresistive (MR) film comprising a nonmagnetic layer may be sandwiched between the two ferromagnetic layers. The MR film may be positioned on a substrate, where the edges of the MR film are in contact with leads. The leads may be in contact with pads. The sensors may provide quasi-digital readout that enable greatly enhanced sensitivity. In some embodiments, biosensors may be arranged as array of sensors. The array of sensors may be arranged as a symmetric or asymmetric N1×N2 array, where N1 and N2 are integers, N1 represents the number of sensors linked together in series, and N2 represents the number of sensor sets in parallel, where each sensor set may comprise one or more sensors. Further, the array of sensors may be coupled to a voltmeter, which may be a single voltmeter in that allows the sensors to all be probed simultaneously.
G01N 27/74 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques des fluides
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
72.
SCALABLE INTER-DIFFUSED ZWITTERIONIC POLYURETHANES FOR DURABLE ANTIBACTERIAL COATINGS
Durable antibacterial coatings are prepared by inter-diffusing zwitterionic polyurethane in acrylic polyurethane. Bacterial attachment is substantially eliminated from the surface of the coatings due to the hydrophilicity of the zwitterionic polyurethane. Long-term antibacterial properties were observed for both Gram-negative and Gram-positive bacteria even when the coatings were constantly challenged by mechanical abrasion.
C09D 175/12 - Polyuréthanes à partir de composés contenant de l'azote et un hydrogène actif, l'atome d'azote ne faisant pas partie d'un groupe isocyanate
C08G 18/75 - Polyisocyanates ou polyisothiocyanates cycliques cycloaliphatiques
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
C08G 18/42 - Polycondensats contenant des groupes ester carboxylique ou carbonique dans la chaîne principale
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
B05D 1/38 - Applications successives de liquides ou d'autres matériaux fluides, p.ex. sans traitement intermédiaire avec traitement intermédiaire
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
C09D 5/14 - Peintures contenant des biocides, p.ex. fongicides, insecticides ou pesticides
73.
SALICYLIC ACID-INDUCIBLE GENE EXPRESSION COMPOSITIONS AND SYSTEMS FOR CELLS
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteurs; Vecteurs; Utilisation d'hôtes pour ceux-ci; Régulation de l'expression
74.
SUPERCONDUCTOR TAPE AND A SUPERCONDUCTOR TAPE STACK AND METHODS OF MAKING AND USING THE SAME
A superconductor tape stack can have good current sharing characteristics and low contact resistivity. An electrically conductive material can be used to couple superconductor tapes to each other. In an embodiment, the superconductor tape stack can include double-sided superconductor tapes in a 2X configuration. In other embodiments, the superconductor tape stack can include single-sided superconductor tapes in a F2B configuration. One or more enhancements may be used to help reduce the contact resistivity. The enhancements can include slotted tapes, a conductive buffer layer stack, a relatively low resistivity substrate, a thinner substrate, a thicker stabilizer layer along sidewalls of the tapes, and combinations thereof. A superconductor tape may also have one or more of the enhancements described with respect to the superconductor tape stack. A magnetic coil can have a winding that includes the superconductor tape stack or the superconductor tape.
H01B 12/06 - Conducteurs, câbles ou lignes de transmission supraconducteurs ou hyperconducteurs caractérisés par leurs formes à couches ou fils déposés sur des supports ou des noyaux
H01B 1/02 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisés; Emploi de matériaux spécifiés comme conducteurs composés principalement de métaux ou d'alliages
75.
ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES
Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p.ex. piracétam, éthosuximide
Embodiments of the present disclosure pertain to methods of customizing a pre-manufactured contact lens for a user by evaluating the conformance of a pre-manufactured contact lens to the user's eye profile (e.g., quantifying eye aberrations of the user's eye profile while the lens is worn) and conforming one or more optical properties of the pre-manufactured contact lens or a duplicate thereof to the user's eye profile based on the evaluation. In some embodiments, the conforming includes mounting the pre-manufactured contact lens on a contact lens mount and altering one or more optical properties of the pre-manufactured contact lens on the contact lens mount. Additional embodiments of the present disclosure pertain to systems for customizing a contact lens. Such systems include a convex contact lens mount with a base area operational for anchoring the convex contact lens mount, and a convex surface operational to mount the pre-manufactured contact lens.
Embodiments of the present disclosure pertain to systems for use in screening at least one binding agent for binding to at least one cell membrane protein. The systems include one or more cells that include the cell membrane protein. The cell membrane protein is genetically engineered to express a first peptide capable of generating a luminescent signal upon interaction with a second peptide. The systems may also include the second peptide. Additional embodiments of the present disclosure pertain to methods of utilizing the systems to screen at least one binding agent for binding to at least one cell membrane protein.
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
G01N 33/58 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique faisant intervenir des substances marquées
222 as an inexpensive reagent for the synthesis gel. Most of the Ge is retained in the synthesis mixture and the small amount incorporated in the zeolite solid (Si/Ge > 100) does not have an appreciable impact on zeolite acidity or other physicochemical properties. The methods disclosed herein circumvent challenges to prepare nano-sized zeolites having dimensions less than 100 nm.
The disclosed qudits interchange the roles of linear and nonlinear in the nonlinear LC resonators formed by existing superconducting qudits. The disclosed qudits include a nonlinear capacitor (e.g., a material that forms charge density waves, a material that forms spin density waves, a ferroelectric material, an incipient ferroelectric material, or a quantum paraelectric material) coupled to a linear or nearly linear inductance (e.g., a high temperature superconductive coil, an array of Josephson junctions in series, etc.). The disclosed qudits can operate at significantly higher temperatures than existing quantum computing technologies due to reduced quasiparticle poisoning and collective quantum behavior that enhance thermal robustness. The disclosed qudits are also easier to manufacture uniformly at scale than existing qubits. Finally, the disclosed qudits are also compatible with many of the gating, coupling, readout, and pulse-sequence methodologies that have already been developed for existing superconducting qubits.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p.ex. couplage ou commande de qubit
Non-invasive methods of risk stratification and treatment of bladder cancer in a subject are based on evaluating D-dimer in a urine sample of the subject, and assay systems thereof for evaluation of D-dimer in the urine sample.
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
Nano-sized zeolites may be prepared using germanium oxide (GeO2) as a component of the overall synthesis composition. This is accomplished by the addition of GeO2 as an inexpensive reagent for the synthesis gel. Most of the Ge is retained in the synthesis mixture and the small amount incorporated in the zeolite solid (Si/Ge>100) does not have an appreciable impact on zeolite acidity or other physicochemical properties. The methods disclosed herein circumvent challenges to prepare nano-sized zeolites having dimensions less than 100 nm.
C01B 39/48 - Autres types caractérisés par leur diagramme de diffraction des rayons X et par leur composition définie utilisant au moins un agent structurant organique
82.
METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES
The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.
A61K 47/55 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique l’agent de modification étant aussi un agent pharmacologiquement ou thérapeutiquement actif, c. à d. le conjugué entier étant un co-médicament, p.ex. un dimère, un oligomère ou un polymère de composés pharmacologiquement ou thérapeutiquement actifs
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.
A method and system for quench detection in high temperature superconductors, such as REBCO (rare-earth barium copper oxide), before thermal runaway. A REBCO superconducting tape is excited as a transmission line forming standing waves. A quench may then be detected in response to detecting a disturbance of the standing waves. In this manner, quench in high temperature superconductors, such as REBCO, is rapidly detected before thermal runaway.
In one aspect, the present disclosure provides organic semiconductors (OSNTs) as well as high-performance electrochemical devices based on the present OSNTs for the production of micro and nano-scale actuators. The present OSNTs may be used in several applications, including movable and implantable interface devices, such as flexible neural microelectrodes. Also provided herein are flexible neural microelectrodes based on conjugated polymer actuators
A61B 5/37 - Modalités, c. à d. méthodes diagnostiques spécifiques Électroencéphalographie [EEG] Électroencéphalographie intracrânienne [EEG IC], p.ex. électrocorticographie [ECoG]
A61B 5/27 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes Étoffes ou tissus conducteurs
A catalyst having a structure according to Formula (1):
A catalyst having a structure according to Formula (1):
A catalyst having a structure according to Formula (1):
wherein R1 and R2 are each independently selected from aliphatic groups, substituted or unsubstituted phenyl groups and silyl groups, or R1 and R2 are bonded together in the form of a cycloalkane, each R3 is hydrogen, an aliphatic group or a halogen, each Ar group is a meta-substituted phenyl group, a para-substituted phenyl group or a meta- and para-substituted phenyl group, M is a transition metal and L1 and L2 are each independently methyl, Cl, Br, NCCH3, DMSO, or L1 and L2 are bonded together in the form of a bidentate ligand.
A method and system for quench detection in high temperature superconductors, such as REBCO (rare-earth barium copper oxide), before thermal runaway. A REBCO superconducting tape is excited as a transmission line forming standing waves. A quench may then be detected in response to detecting a disturbance of the standing waves. In this manner, quench in high temperature superconductors, such as REBCO, is rapidly detected before thermal runaway.
G01R 23/02 - Dispositions pour procéder à la mesure de fréquences, p.ex. taux de répétition d'impulsions; Dispositions pour procéder à la mesure de la période d'un courant ou d'une tension
A method including capturing carbon dioxide (CO2) from air (e.g., atmosphere) in an absorber in which the air contacts a base (e.g., a hydroxide, such as potassium hydroxide KOH and/or sodium hydroxide (NaOH)) to produce a carbonate (e.g., potassium carbonate (K2CO3) and/or sodium carbonate (Na2CO3)); precipitating one or more (e.g., carbonate) salt from an aqueous solution comprising salt (a brine) to provide an aqueous solution comprising a chloride (e.g., potassium chloride (KCl) and/or sodium chloride (NaCl)); using electrochemical regeneration to convert the chloride to electrochemically regenerated product comprising the base (e.g., KOH and/or NaOH); and recycling at least a portion of the electrochemically regenerated product comprising the base to the capturing of the CO2 from the air. A system for carrying out the method is also provided.
C01D 3/06 - Préparation par traitement de saumures, eau de mer ou lessive épuisées
B01J 20/04 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtration; Absorbants ou adsorbants pour la chromatographie; Procédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des composés des métaux alcalins, des métaux alcalino-terreux ou du magnésium
B01D 53/02 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p.ex. chromatographie préparatoire en phase gazeuse
C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes
89.
ORGANIC SEMICONDUCTOR NANOTUBES FOR ELECTROCHEMICAL BIOELECTRONICS AND BIOSENSORS WITH TUNABLE DYNAMICS
In one aspect, the present disclosure provides organic semiconductors (OSNTs) as well as high-performance electrochemical devices based on the present OSNTs for the production of micro and nano-scale actuators. The present OSNTs may be used in several applications, including movable and implantable interface devices, such as flexible neural microelectrodes. Also provided herein are flexible neural microelectrodes based on conjugated polymer actuators
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
A61B 5/27 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes Étoffes ou tissus conducteurs
90.
2 CAPTURE, MINERALIZATION, AND LITHIUM AND OTHER METAL EXTRACTION FROM BRINE
C25B 1/46 - Production simultanée d'hydroxydes des métaux alcalins et de chlore, de ses oxyacides ou de ses sels, p.ex. électrolyse chlore-alcali dans des cellules à diaphragmes
C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytes; Régénération des électrolytes
B01D 53/14 - SÉPARATION Épuration chimique ou biologique des gaz résiduaires, p.ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
The present disclosure provides methods for risk stratification or management of recurrent or new bladder cancer in patients by evaluating urine D-dimer levels. In certain embodiments, the D-dimer can be assayed by ELISA (enzyme-linked immunosorbent assay) or LFA (lateral flow assay). In the methods provided herein, in response to a urine test being positive for D-dimer, the patient is subject to a biopsy (via a cystoscopy) to confirm the diagnosis. If the urine test is negative for D-dimer, the patient will be reviewed at a subsequent follow-up visit. These methods provide a majority of patients with an alternative to unnecessary invasive or expensive procedures with suboptimal diagnostic profiles, leading to savings for the patient and overall healthcare industry, and reduction of incidence of cystoscopy-related side-effects.
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p.ex. liaison anticorps-antigène, liaison récepteur-ligand
G01N 33/566 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand
92.
Fluorinated polymerization catalysts and methods of making and using the same
Described herein are polymerization catalysts having a structure according to formula (1):
wherein
2 is a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic. Also described herein are polymers having a terminus having a structure according to Formula (3):
2 is a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic.
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
93.
PLASMONIC SENSORS AND ACTUATORS FOR IMAGING BIOLOGICAL MICROPARTICLES AND NANOPARTICLES
Board of Regents, The University of Texas System (USA)
Inventeur(s)
Shih, Wei-Chuan
Ohannesian, Nareg
Lin, Steven H.
Abrégé
Ultra near-field index modulated plasmonic nano-aperture label-free imaging methods and techniques are useful for imaging and detection of biological microparticles and nanoparticles such as circulating tumor exosomes (CTEs), bacteria and vimses. The methods and techniques utilize a high-density array of gold, silver, or gold/silver alloy nanodisks, in some cases on an undercut or invisible substrate. Given the relatively large nanodisk dimensions, the nanodisk array may feature a significantly blue-shifted LSPR extinction peak due to both far-field plasmonic coupling and substrate undercut. The ultra near-field imaging methods have the ability to image nanoparticles as small as 25 nm.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p.ex. génie protéique ou administration de médicaments
G01N 33/553 - Support métallique ou recouvert d'un métal
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
G01N 33/574 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour le cancer
94.
NANO-MICRO PARTICLE FLUID FOR CLEANING DIRTY AND GREASY SURFACES AND PIPES
A cleaning composition is provided herein. The cleaning composition contains a plurality of metal particles and a base fluid. The plurality of metal particles have an average size in a range of from about 1 nanometer (nm) to about 10,000 micrometers (μm), and are dispersed in the base fluid. The cleaning composition is configured to generate an exothermic reaction when contacted with one or more components on a surface and water to facilitate removal of the one or more components from the surface. Methods of making and utilizing the cleaning composition are also provided.
Described herein are palladium-based polymerization catalysts having a diimine ligand and a fluorinated ester chelate. Also described herein are polymers formed using palladium-based polymerization catalysts, where the polymers have a terminus having a structure including a fluorinated alkane, alkene or alkyne, a fluorinated aromatic, a fluorinated cycloalkane or cylcoalkene, a fluorinated heteroaromatic, or a fluorinated heterocyclic.
C08F 4/26 - Composés métalliques autres que les hydrures et autres que les composés organiques de métal; Complexes d'halogénures de bore ou d'halogénures d'aluminium avec des composés organiques contenant de l'oxygène de manganèse, des métaux du groupe du fer ou des métaux du groupe du platine
C08F 4/80 - Métaux; Hydrures métalliques; Composés organiques de métal; Leur utilisation comme précurseurs de catalyseurs choisis parmi les métaux non prévus dans le groupe choisis parmi les métaux du groupe du fer ou les métaux du groupe du platine
Substituted phenylpyridine compounds are disclosed. Also disclosed is the use of the phenylpyridine compounds in methods of treatment and for inhibiting RIPK2 and/or NOD2 cell signaling.
C07D 213/38 - Radicaux substitués par des atomes d'azote liés par des liaisons simples comportant uniquement de l'hydrogène, ou des radicaux hydrocarbonés, liés à l'atome d'azote substituant
C07D 213/61 - Atomes d'halogènes ou radicaux nitro
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/444 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. amrinone
A61P 19/00 - Médicaments pour le traitement des troubles du squelette
97.
ONBOARD CIRCUITS AND METHODS TO PREDICT THE HEALTH OF CRITICAL ELEMENTS
A system for monitoring a circuit, comprising a device under test, such as a power field effect transistor or capacitor, coupled to a power source and a signal source and configured to generate a power output using the signal source, a current output, a voltage output and an end of life detector coupled to the current output and the voltage output and configured to generate a first impedance as a function of the current output and the voltage output, to compare the first impedance to a second impedance and to generate an indicator if the first impedance exceeds the second impedance.
The present invention relates to a culture media system that useful for the isolation and epigenetically stable propagation of normal stem cells in culture which are derived from columnar epithelial tissues and cancer stem cells from epithelial cancers. In certain embodiments, the culture system is a feeder-free system.
A headset device is described herein comprising a lower band comprising an outer surface and an inner surface, wherein a front portion of the lower band comprises at least one sensor positioned on the inner surface, wherein at least one arm extends from the lower band, wherein a proximal end of the at least one arm is rotatably attached to the lower band, wherein a distal end of the at least one arm comprises a sensor, wherein a rear portion of the lower band comprises adjustable straps for adjusting a circumference of the lower band. The headset device comprises an upper band comprising an upper surface and a lower surface, wherein at least one dry electrode component extends from the lower surface of the upper band, wherein the upper band is adjustably attached to the lower band.
A61B 5/291 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
A61B 5/297 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électrorétinographie [ERG]
A headset device is described herein comprising a lower band comprising an outer surface and an inner surface, wherein a front portion of the lower band comprises at least one sensor positioned on the inner surface, wherein at least one arm extends from the lower band, wherein a proximal end of the at least one arm is rotatably attached to the lower band, wherein a distal end of the at least one arm comprises a sensor, wherein a rear portion of the lower band comprises adjustable straps for adjusting a circumference of the lower band. The headset device comprises an upper band comprising an upper surface and a lower surface, wherein at least one dry electrode component extends from the lower surface of the upper band, wherein the upper band is adjustably attached to the lower band.
