Systems, methods, and techniques disclosed and contemplated herein relate to processing high level radioactive waste (HLW). Exemplary techniques are applicable to various fuel types, such as metal/chloride salt HLW streams from pyroprocessing of sodium bonded metallic fast reactor fuel; metal and halide salt HLW from molten salt reactors; and SiC/pyrolytic carbon from mechanically breached TRISO (tri -structural isotropic particle fuel) kernels with oxide fission products (FPs) from reprocessing. Exemplary waste forms are cermets.
2.
PORTABLE RAILROAD TRACK COMPONENT INSPECTION SYSTEM
Described herein is a lightweight, power-efficient edge computing system, called the Autonomous Power-efficient Track Inspection System (APTIS), designed specifically for railroad track component inspection, and methods for making same, using an edge-computing device equipped with a custom computer vision model for meticulous track inspection that employs advanced deep learning and AI technologies, enabling automated detection and evaluation of the condition of various track components in concert with built-in cameras for surveillance.
The disclosure deals with system and method for image gradient and derivative computation image processing. Noise, image sharpness, orientation, empirical parameters, and computational complexity are examples of image gradient and derivative computation challenges. Many traditional kernel-based operators excel at tackling one of these problems, but trade off their ability to handle others. Two new gradient detection kernels based on two-dimensional high order Taylor Series expansion tackle many such problems. The first kernel uses a wide range of the pixels in view to suppress noise, thereby improving the gradient intensities of edges. The second kernel builds on the first to leverage its noise suppression benefits while tackling an additional problem of degraded and low contrast edge boundaries. It can detect smooth lines in the presence of discontinuities and poor quality. The filter architecture allows for precise gradient calculation, edge detection, and orientation determination to less than one degree of the true value even when faced with signal to noise ratios that exceed 0.75.
Disclosed are electrolyzer systems and methods that combine forward osmosis with electrolysis to produce hydrogen from a water source such as seawater. The systems can operate with low energy input through immersion in the water source or by flowing the water source past osmotic membranes of a system to establish osmosis and simultaneous electrolysis.
C25B 9/21 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms two or more diaphragms
C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
The present disclosure is generally directed to methods for forming anhydrous rare earth and actinide phosphate minerals. In some embodiments of the present disclosure, the method generally comprises subjecting rare earth or actinide phosphates or salts thereof to microwave radiation.
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (USA)
UNIVERSITY OF MARYLAND, COLLEGE PARK (USA)
UNIVERSITY OF VIRGINIA PATENT FOUNDATION (USA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
UNIVERSITY OF SOUTH CAROLINA (USA)
Inventor
Hobart, Karl D.
Anderson, Travis J.
Tadjer, Marko J.
Jacobs, Alan G.
Graham, Samuel
Aller, Henry
Hopkins, Patrick
Goorsky, Mark
Khan, Asif
Feygelson, Tatyana I.
Pate, Bradford B.
Abstract
In one aspect, the disclosure relates to a device comprising a plurality of semiconductor layers; a phonon bridge layer formed on the plurality of semiconductor layers; a gate electrode set into the phonon bridge layer and in contact with a surface of the plurality of semiconductor layers; and a diamond layer formed over the phonon bridge layer. The phonon bridge layer can include materials that have a speed of sound in-between the speed of sound for the diamond layer and the speed of sound of the semiconductor layer that is in contact with the phonon bridge layer. In one aspect, the device is a transistor, such as a high electron mobility transistor. The disclosure, in another aspect, relates to methods of making the devices as disclosed herein.
H01L 21/28 - Manufacture of electrodes on semiconductor bodies using processes or apparatus not provided for in groups
H10D 62/83 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge
H01L 21/768 - Applying interconnections to be used for carrying current between separate components within a device
H01L 23/373 - Cooling facilitated by selection of materials for the device
Described herein are systems and methods to reduce the difficulty of setting up and managing a web interface for an Industrial Edge Device app and to enable bi-directional communication between Python® and a web interface.
In general, disclosed herein are compositions and methods for treating pseudomyxoma peritonei (PMP). Compounds disclosed herein for treating pseudomyxoma peritonei may include PMP inhibitors of Formula I:
In general, disclosed herein are compositions and methods for treating pseudomyxoma peritonei (PMP). Compounds disclosed herein for treating pseudomyxoma peritonei may include PMP inhibitors of Formula I:
In general, disclosed herein are compositions and methods for treating pseudomyxoma peritonei (PMP). Compounds disclosed herein for treating pseudomyxoma peritonei may include PMP inhibitors of Formula I:
or a pharmaceutically acceptable salt thereof.
The biosensor involves novel tone burst interdigitated transducer (TB-IDT) electrodes and multidirectional focused interdigitated electrodes for better sensitivity. The TB-IDT electrodes feature varied amplitude and width of electrode fingers over the length of the biosensor to cover a wider range of frequency access which does not rely on a single central frequency-based detection parameter. The multiple-frequency, multi-directional, and multi-amplitude accessibility reduces the occurrence of false-negatives and false-positives, leading to increased and improved sensitivity. The biosensor produces instantaneous diagnostic results and is highly sensitive in terms of broader bandwidth. The wide variety of compatible sensing receptors may be combined to accommodate detection of multiple target molecules using the same biosensor.
Methods and compositions are described herein for modulating protein synthesis, especially monosome translation and DNA damage response, especially short-patch base excision repair (SP-BER), NHEJ and HR for treating a disorder. Compositions include a therapeutically effective amount of a tyrosine or a resveratrol derivative.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
11.
NEURAL REPAIR THROUGH INHIBITION OF REG3A SIGNALING
In general, disclosed herein are methods for increasing nerve regeneration. The method includes, for instance, administering an effective amount of an agent comprising a sequence at least 95% identical to SEQ ID NOs: 1-3 to a subject, wherein the agent depletes or inhibits Reg3A or KHSRP expression in neurons of the subject.
Disclosed are ion extraction electrochemical cells, systems incorporating the cells, and applications thereof, including but not limited to selective ion extraction from seawater/brine for mining operations, recycling operations, and isotope separations. Methods include extraction of metals or isotopes from an aqueous phase, e.g., mining of metals from saltwater or synthetic or natural brines. Systems and methods can be utilized in one embodiment for lithium mining.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
Described herein are digital twin methods and systems integrating advanced computational algorithms and user-centric interfaces to transform the management of gas turbine engines, which provide comprehensive real-time analytics, extending beyond basic performance prediction, design, analysis and monitoring as well as capabilities for predictive maintenance, design and efficiency optimization, and fault diagnosis, all accessible to operators regardless of their expertise in turbine physics.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
G06F 30/15 - Vehicle, aircraft or watercraft design
G06F 119/02 - Reliability analysis or reliability optimisationFailure analysis, e.g. worst case scenario performance, failure mode and effects analysis [FMEA]
G06F 119/08 - Thermal analysis or thermal optimisation
14.
TIME DOMAIN NMR FOR OBTAINING CETANE NUMBER OF LIQUID FUELS
The disclosure deals with a system and methodology for using a time-domain nuclear magnetic resonance (TD-NMR) system to measure the T2 relaxation curve of a sample, such as liquid hydrocarbon fuels. A machine-learned (ML) model is trained to predict a Derived Cetane Number (DCN) for the sample, based on the T2 relaxation curve data of the sample. The TD-NMR system is compact and can be placed in situ in a fuel system to predict the DCN of the stored fuel, to allow an operator to adapt operation of a corresponding engine accordingly, for maximized performance in real time. The ML Model can be trained using selected structural data features of the T2 relaxation curves, to bias the ML model for better working with either of hydrocarbon samples or jet fuel samples, or optimized to work with unknown samples.
In general, the present disclosure is directed to an adhesive composition. The adhesive composition may include a functionalized lignin and a hardener. For instance, the hardener may include a silyl ether. The functionalized lignin and hardener may be present in the adhesive composition at a weight ratio of from about 1:10 to about 10:1.
In general, the present disclosure is directed to methods for producing an electrode having a crosslinked binder. In some embodiments the binder may comprise polyvinylidene fluoride. Said crosslinking may allow for higher loading capacities, increased ionic conductivity and/or durability. Further, electrodes and batteries comprising said electrodes which have crosslinked binders are described herein.
An example device includes at least one processor configured to receive an indication of a fault in submodules in a first arm of a first phase leg of a modular multilevel converter (MMC), cause it to bypass an equal number of healthy submodules in a second arm of the first phase leg, determine a zero-sequence voltage for each phase leg, and determine, for each phase leg, based at least in part on the zero-sequence voltage, a respective modified phase leg reference signal. The respective modified phase leg reference signal for the first phase leg may be determined further based in part on a reduced utilization factor for the first phase leg. The processor is further configured to determine, based on the respective modified phase leg reference signal for each phase leg, gate driver signals for submodules in the MMC and cause it to operate using the signals.
Embodiments of the invention are directed to a computer-implemented method that includes inputting a first input into a plansformer that includes a transformer-based neural network (NN). The first input includes symbols and a problem. The computer-implemented method further includes, in response to the inputting, receiving as output from the plansformer a plan for solving the problem.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events; Entertainment services, namely, conducting intercollegiate games in the sports of baseball, softball, cross country, track and field, soccer, golf and volleyball.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events; Entertainment services, namely, conducting intercollegiate games in the sports of baseball, softball, cross country, track and field, soccer, golf and volleyball.
21.
CYCLOPROPANOL AS A BIOORTHOGONAL WARHEAD FOR ELECTROCHEMICALLY CONTROLLED BIOCONJUGATION APPLICATIONS
In general, disclosed herein are methods for producing a chemoselectively modified biomolecule. The method may include providing a biomolecule, which may include a bioconjugation warhead at a specific site of the biomolecule. Also, the method may include selectively oxidizing the halogen donor compound of the bioconjugation warhead at an electrochemically efficient voltage to generate a halogen radical. Also, the method may include contacting the halogen radical with the bioconjugation warhead at a constant voltage to form an electrophilic warhead. Also, the method may include reacting the electrophilic warhead with a coupling partner comprising a nucleophilic group of the biomolecule to conjugate the electrophilic warhead to the biomolecule.
Disclosed herein are CDK8/19 degraders and methods of making and using the same. The CDK8/19 degrader is a heterobifunctional compound, or a pharmaceutically acceptable salt thereof, comprising a CDK8/19 targeting moiety, a ubiquitin ligase ligand moiety, and a linker linking the CDK8/19 targeting moiety and the ubiquitin ligase ligand moiety.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
In general, the present disclosure is directed to systems and methods of evaluating a subject's risk of one or more complications associated with pelvic organ prolapse surgery. The method comprising: obtaining, by a computing system comprising one or more computing devices, sample data associated with the subject; obtaining, by a computing system comprising one or more computing devices, medical record data associated with the subject; inputting, by the computing system, the sample data into a machine-learned surgical model; receiving, by the computing system as an output of the machine-learned surgical model, one or more predictions of post-surgical complications of mesh exposure through a vaginal wall associated with the subject; and performing a pelvic organ prolapse repair surgery on the subject.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
24.
METHODS FOR INHIBITING PARASITIC GLUCOKINASE AND/OR HEXOKINASE
Inhibitors directed at enzymes of the pentose phosphate pathway of protozoan parasites, e.g., Trypanosoma cruzi glucokinase, are described. Inhibitors are derivatives of gossypol (2,2′-Bis(formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene). The inhibitors can specifically target glucokinase and hexokinase of Trypanosoma cruzi (T. cruzi), Trypanosoma brucei (T. brucei), and Leishmania spp. and are useful in treatment of parasitic diseases including Chagas' disease and African sleeping sickness, among others.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/4152 - 1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
Employing methodologies and systems to detect damage initiation and growth inside a composite material (matrix cracking, delamination, fiber break, fiber pullout, etc.) wherein damage produces high-frequency acoustic emission (AE) waves that are transported to recording sensors along with relatively lower frequency waves representing the flexural deformation of the impacted composite structure.
G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
G01N 29/44 - Processing the detected response signal
Disclosed herein are methods for forming a heterostructure including a matrix and pores disposed therein with different elemental compositions. The method generally sequential addition of metal oxide nanoparticles to block copolymer micelles which are capable of persistently binding metal oxide nanoparticles.
C08F 299/02 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
27.
IDENTIFICATION OF ACTIVITIES OF GUT MICROBE METABOLITES
Disclosed are treatment methods and compositions developed by the method utilizing Alistipes-derived sulfonolipids in treatment of a variety of diseases, including inflammatory bowel diseases and cancers. Also disclosed are methods for determining a correlation between a gut microbe metabolite and a disease state. The method utilizes a biosynthetic enzyme-guided correlation approach to determine particular metabolites functional in human health as well as a guide for examining the functionality thereof.
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
28.
BIMETALIC FUEL CELL CATALYTS FOR DEHYDROGENATION REACTIONS
Bimetallic catalysts and methods of utilizing the catalysts in hydrogen generation applications are described. Bimetallic catalysts can be free of platinum group metals and less expensive yet highly active in dehydrogenation applications. Systems and methods are described utilizing the bimetallic catalysts as a hydrogen transfer catalyst. Hydrogen storage applications are described utilizing the catalysts with organic hydrogen carrier materials such as saturated cyclic hydrocarbons.
Methods are described for formation of a promoted catalysts. Promoted catalysts include metal oxide promoted silver catalysts for use in ethylene oxide production. Methods utilize a combination of relative surface free energies of catalyst and promoter materials, promoter loading concentrations, and calcination temperatures to encourage deposition and diffusion of promoters on catalyst metals of supported catalysts.
Conventional proprioceptive studies use commercial vibrators. Such vibrators have major drawbacks as their amplitude and frequency adjustments are limited or outside the range of frequency that stimulates the specific human biological sensors making them non-specific to each individual or muscle. At times, they are also expensive and not wearable. The presently disclosed subject matter relates to system and method for custom-developed vibrational systems having various adjustable and flexible parameters such as amplitude, frequency, delay time, and other user requirement functions that can work simultaneously and can be applied to different individuals and to different muscle spots. The presently disclosed system and method are robust, compact, wearable, economical, and easy to operate.
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/316 - Modalities, i.e. specific diagnostic methods
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
33.
METHODS AND FORMULATIONS FOR IMPROVING THE PHARMACOKINETIC PROPERTIES OF NUTRACEUTICAL COMPOUNDS
In general, the present disclosure is directed to compositions and methods for formulating thereof for oral administration. The composition may be in the form of a hydrogel. The hydrogel may include a phospholipid complex comprising a solubilized phospholipid and a solubilized nutraceutical compound.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
34.
LOW CROSSOVER ION EXCHANGE MEMBRANES FOR REDOX FLOW BATTERIES
Ion exchange membranes and methods for forming the membranes are described. The ion exchange membranes can be incorporated in a redox flow battery. The membranes can exhibit high conductivity of desired ions (e.g., protons or hydroxide ions) as well as stability and durability in the redox flow battery environment while also exhibiting low permeability to redox couple species. The membranes are formed according to a polyphosphoric acid formation technique and subjected to a densification and thermal treatment.
A disclosed approximate tensor processing unit (APTPU) includes two main components: (1) approximate processing elements (APEs) consisting of a low-precision multiplier and an approximate adder, and (2) pre-approximate units (PAUs) which are shared among the APEs in the APTPU's systolic array, functioning as the steering logic to pre-process the operands and feed them to the APEs. Performance of the disclosed APTPU across various configurations and various workloads shows that the disclosed APTPU's systolic array achieves delay, area, and power reductions, while realizing comparable accuracy to previous designs.
G06F 15/80 - Architectures of general purpose stored program computers comprising an array of processing units with common control, e.g. single instruction multiple data processors
G06F 5/01 - Methods or arrangements for data conversion without changing the order or content of the data handled for shifting, e.g. justifying, scaling, normalising
36.
METHOD FOR THE REVIVAL OF MICROGLIA AND ASTROCYTES AND APPLICATIONS THEREOF
Methods are described for treatment of Alzheimer's Disease as well as other neurodegenerative disorders in which microglia and/or astrocyte abilities have been altered and impaired. Methods include brain-targeting of PD-L1 using a brain targeted nanogel loaded with PDL1 antibody and functionalized with two particular targeting ligands. The nanogels can successfully cross the blood brain barrier to release the antibody and reduce PD-L1 expression in the brain while preserving the integrity of the BBB.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
37.
Design of Acoustic Metamaterials Based on Liquid Crystal Skyrmions
The disclosure deals with a system and method for the design of acoustic metamaterials based on liquid crystal skyrmions. Noise attenuation, sound focusing, and harvesting acoustic wave energy are challenging issues that the technological community currently faces. The disclosed thermodynamically driven metamaterial facilitates the design of unique architectures with several acoustic applications, including sound attenuation and acoustic energy harvesting. This disclosed structure includes spherical shells in a hexagonal arrangement (or cubic), which can be designed in any size and additively manufactured for end use applications.
The disclosed system and methodology enable coexistence of networking and sensing on next-generation millimeter-wave (mmWave) picocells for traffic monitoring and pedestrian safety at intersections in all weather conditions. Existing wireless signal-based object detection systems suffer from limited resolution, and their outputs may not provide sufficient discriminatory information in complex scenes, such as traffic intersections. The disclosed system uses 5G picocells, which operate at mmWave frequency bands and provide higher data rates and higher sensing resolution than traditional wireless technology. It is difficult to run sensing applications and data transfer simultaneously on mmWave devices due to potential interference. MmWave devices are vulnerable to weak reflectivity and specularity challenges which may result in loss of information about objects and pedestrians. To address such challenges, the disclosed design uses customized deep learning models that not only can recover missing information about the target scene but also enable coexistence of networking and sensing.
A catalyst support containing praseodymium oxide and dysprosium oxide, supported catalysts using the support, and methods of using the supported catalysts to catalyze the formation and degradation of ammonia.
A catalyst including ruthenium, a promoter metal, and a second metal, optionally disposed on a support, and methods of using the catalyst to catalyze the formation of ammonia.
Described herein is an over-the-air computation (OAC) scheme for a federated k-means clustering algorithm to reduce the per-round communication latency when implemented over a wireless network. The OAC scheme relies on an encoder exploiting the representation of a number in a balanced number system and computes the sum of the updates for the federated k-means via signal superposition property of wireless multiple-access channels non-coherently to eliminate the need for precise phase and time synchronization.
A sea going instrument is used to measure the 234Th activity on settling particles in the ocean as an indicator of carbon sequestration as export from the surface ocean. The instrumentation can be adapted to multiple sampling platforms with the goal of providing high temporal resolution 234Th flux measurements at multiple locations and depths in the ocean. This proxy of mass flux is used to complement other in situ sensors to provide high resolution data for features such as Chlorophyll-a concentration (Chla), accessory pigments, and PIC normalized to mass flux.
G01T 1/178 - Circuit arrangements not adapted to a particular type of detector for measuring specific activity in the presence of other radioactive substances, e.g. natural, in the air or in liquids such as rain-water
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
Disclosed herein are methods, compositions, and kits for treating a subject in need of a treatment for a cancer. The method comprises administering to the subject a CDK8/19 inhibitor and a mTOR inhibitor.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
The disclosure relates to methodology and apparatus for a non-coherent over-the-air computation (OAC) methodology to calculate the majority vote (MV) reliably in fading channel. The disclosed approach relies on modulating the amplitude of the elements of complementary sequences (CSs) based on the sign of the parameters to be aggregated. Since the disclosed method does not use channel state information at the nodes, it is compatible with time-varying channels. The methodology is useful for an unmanned aerial vehicle (UAV) guided by distributed sensors based on the MV computed with the method. The method improves the computation error rate with a longer sequence length in fading channel while maintaining the peak-to-mean-envelope power ratio of the transmitted orthogonal frequency division multiplexing signals to be less than or equal to 3 dB.
H04W 24/02 - Arrangements for optimising operational condition
H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
Massively parallel systems and methods are described suitable for high throughput and large-scale production of highly consistent nanoparticles. The systems include a device that utilizes a single pump to pump a reaction mixture simultaneously through multiple formation channels. One or more devices can be utilized in a single production line, and a system can include multiple production lines. A device of a system provides essentially identical interaction conditions throughout the multiple channels with highly controllable and consistent pumping conditions to provide well-controlled and consistent flow conditions in the channels. This consistency allows for well-defined reaction formation chemistry and thereby provides highly consistent nanoparticle products in large quantities in a short time period.
A hyperspectral imaging apparatus based on a monolithic or free space optical spatial heterodyne spectrometer (SHS) design, array detector, electromagnetic radiation source, and optical collection element is described. The apparatus enables the simultaneous acquisition of spatially isolated Fizeau fringe patterns, each having an encoded light product that is decoded to produce a spectral fingerprint of the interrogated object. Features specific to the SHS, such as a large entrance aperture, large acceptance angle, and no moving parts, enable a variety of optical collection schemes including lens arrays, solid-core and hollow core waveguides, and others. In one example, a microlens array (MLA) is configured with the hyperspectral imaging apparatus to simultaneously image many hundred spatially isolated Fizeau fringe patterns while interrogating an object using an electromagnetic radiation source. Each Fizeau fringe pattern recorded by the array detector is decoded to produce a full Raman or laser-induced breakdown spectroscopy (LIBS) spectrum. Compared to prior art, the hyperspectral imaging apparatus overcomes the primary limitations of needing to trade time resolution for both spectral and spatial data density because the imaging apparatus simultaneously acquires both spectral and special information. Based on the selection and configuration of diffraction gratings, the grating aperture size, Littrow wavelength (i.e., heterodyne wavelength), and optical collection configuration, the apparatus can be tailored to produced low or high spectral resolution with a spectral bandpass that covers a portion or the entire Raman spectral range (up to 4200 cm−1) and for LIBS as well.
Methodology and corresponding apparatus pertain to human sleep posture monitoring, using a wireless signal-based monitoring system leveraging millimeter-wave technology. A software-only human sleep posture monitoring solution based on millimeter-wave (mmWave) wireless-based solutions enables fine-grained posture monitoring under no light without being privacy-invasive. In zero visibility, body joint information and changes can be extracted directly from mmWave imaging using improved capabilities for extracting human sleep posture data from millimeter-wave wireless systems. A single-person sleep posture monitoring system leverages signal processing and deep learning models to enable fine-grained monitoring continuously and non-intrusively with commodity (i.e., generally available) mmWave devices. The system directly predicts joint locations from reflected mmWave signals by learning the hidden association between them from thousands of data samples. Learning is accomplished through a customized Deep Convolutional Neural Network (DCNN), that predicts the 3D locations of several key body joints from the reflected signals captured by multiple mmWave antennas.
Described herein are methods, systems, and pharmaceutical compositions for using Trigonelline (TRG), an alkaloid found in the seeds of many plants, including coffee beans, to attenuate Spike-protein exacerbated lipotoxicity and mitochondria stress in endothelial cells and cardiomyocytes to protect the heart from injuries caused by SARS-CoV-2 Spike protein under obesity.
Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies. The disclosure also provides an oral dosage form comprising an amount of resveratrol comprising a therapeutically effective amount of cis-resveratrol and not more than 200 mg of trans-resveratrol.
Described herein are mobile nuclear micro-reactors, systems for same, as well as methods of making mobile nuclear micro-reactors in the hundreds of kilowatt range, scalable to higher powers, capable of operating, at least, ten years without refueling while designed to eliminate fuel resupply tails that have proven so costly in conflicts over the past two decades or more.
G21C 7/08 - Control of nuclear reaction by application of neutron-absorbing material, i.e. material with absorption cross-section very much in excess of reflection cross-section by displacement of solid control elements, e.g. control rods
G21C 7/103 - Control assemblies containing one or more absorbants as well as other elements, e.g. fuel or moderator elements
Described herein are systems and methods for secure and usable authentication techniques for drone delivery that leverages biometric information of faces, unlike traditional biometrics-based approaches, it does not need users to enroll their biometric information and is impervious to common drone attacks.
The disclosure deals with methodology and involved or associated systems for using infrared technology to detect tissue damage below the skin. Pressure and shear stress can damage the microvascular structure below the skin, which is not visible to the naked eye. Infrared thermography is a non-invasive mechanism to measure skin temperature via thermal radiation. Changes (restrictions) in blood flow below the skin can result in microvascular damage to the tissue, and directly impact skin temperature, which can be detected by infrared thermography. Infrared thermography can detect these changes at the site of tissue damage. This disclosure uses affordable infrared thermography to detect changes in temperature related to blood flow alterations, supported with AI. Using serial images, AI can detect an emerging DFU (Diabetic Foot Ulcer) in DM (Diabetes Mellitus) patients through deviations in skin temperature.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
54.
SLEEP DISRUPTIONS IDENTIFICATION FROM MILLIMETER-WAVE WIRELESS SYSTEMS
Methodology and corresponding apparatus pertains to sleep disruption monitoring, including use of a wireless signal-based monitoring system leveraging millimeter-wave technology. A software-only sleep disruption monitoring solution can be based on millimeter-wave (mmWave) wireless-based solutions which leverage cross-correlation between successive mmWave reflected signals and a Hidden Markov Model (HMM) to identify respective sleep (rest) and disruptions (toss-turn) periods. A toss-turn detector module can identify sudden movements during sleep from mmWave wireless signals and classify the sleeping period into the two states: Rest or toss-turn. Whenever mmWave transceivers (such as included in 5G-and-beyond devices) are implemented as access points, in mass privacy non-invasive sleep disruption monitoring can be provided for consumers at home.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
55.
STRONG POLYBENZIMIDAZOLE (PBI) GEL MEMBRANES WITH HIGH CONDUCTIVITY
Disclosed are polybenzimidazole gel membranes that exhibit both high proton conductivity and high tensile strength at break. The membranes are formed with a high percentage of tetraaminobiphenyl monomers and naphthalene dicarboxylic acid monomers.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Downloadable electronic publications in the nature of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators. Printed publications, namely, reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators. Educational services, namely, the publication of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators; research services, namely, providing education research services for use in the development of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators.
CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS – CNPEM (Brazil)
Inventor
D'Antonio, Edward L.
Mercaldi, Gustavo F.
Abstract
Colorimetric based high-throughput assay systems are described that utilize colorimetric agents that exhibit both high water solubility characteristics in both an oxidized and a reduced state and exhibit intense UV/vis absorption in only one of the oxidized or reduced states, with absorption in the other state being either non-existent or very low. Disclosed assays are useful in examining the efficacy of enzyme inhibitors, including helicase or kinase inhibitors.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
C12N 9/99 - Enzyme inactivation by chemical treatment
C12Q 1/32 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving dehydrogenase
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
58.
PIEZOELECTRIC ACOUSTIC BIOSENSOR AND USES THEREFORE
Disclosed is an acoustic-based biosensing platform that can be utilized in point of care applications and can provide rapid results with both high sensitivity and high selectivity. The sensing platform includes a plurality of piezoelectric cantilevers conjugated with a specific binding member for a bioanalyte of interest. Upon excitation of an excitation cantilever, acoustic feature extraction from response signals can provide information with regard to the presence or quantity of a bioanalyte of interest.
H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
Cellulose-based scaffolds for enzyme immobilization and methods for forming and using the scaffolds are described. The scaffolds incorporate delignified bamboo that can be functionalized to include an enzyme immobilized at a surface of the delignified bamboo via an alkylamine linkage. Disclosed scaffolds can be utilized in enzyme-based flow bioreactors.
An autonomous all-terrain robot for agricultural industries is designed to install support stakes inground on plant beds while being able to self-navigate. Apparatus and method provide a robot having the ability to perform the actions of navigating between plant beds and to determine a precise location and depth to place each supporting stake. The purpose of the stakes is to support the plants with weak stems. Part of some planting processes require stakes to support a plant as it begins to grow. from a two- or three-week-old plant to a fully mature plant. The presently disclosed subject matter provides a machine that can aid in the planting process of both bell peppers and eggplants and similar crops, used to drive stakes into planting beds. The presently disclosed technology (such as specific robotic device or robot) can work 24/7, weather permitting, while providing an efficient and completely hands-free way to install stakes needed in the planting process.
Disclosed are brain-targeted antibody delivery systems, methods of forming the systems, and methods of using the systems. The systems include hydrophilic nanogels based upon poly(ethylene glycol) copolymers. The nanogels can encapsulate an antibody for delivery to the brain and can include ligands for blood brain barrier (BBB) receptors on the surface, and as such, can utilize a systemic route of administration for delivery of the antibody to the brain and the eye. The systems can be utilized for systemic delivery routes to deliver the antibody to the brain side of the blood brain barrier and inside glial cells and degrade its corresponding protein. The systems can be utilized in treatment of neurodegenerative or retinal disorders.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
62.
SYSTEM AND METHOD TO MEDIATE SOCIAL MEDIA PLATFORMS AUTOMATICALLY FOR USER SAFETY
The disclosure deals with a system and method for mediating social media platforms automatically for user safety, including in particular for automatically or semi-automatically mediating social media platforms for user safety. People meet on online platforms and discuss a variety of topics. Moderators associated with those platforms play an important role in making the platform convenient and safe to users. This disclosure addresses detecting users who can act as potential moderators of an online group of support seekers and support providers in an online social media platform operating on the Internet. Such users are classified to identify the class of supportive users and class of non-supportive users of an online group. Received suggestions and other acquired data are used to identify a potential moderator for the online group. Acquired data on supportive and non-supportive users, as well as on harmful users, is then automatically supplied to the moderator.
H04L 51/52 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail for supporting social networking services
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
Described herein are methods, systems, and processes for in-situ oxide dielectric deposition in the same reactor, integrating III-Nitride and III-Oxide technology using N2 as carrier gas that results in a lower density of interface traps (charges).
Described herein are a low-cost, non-destructive, and contact-free intelligent inspection system that is field-deployable on a geometry car, high-rail vehicle, or other types of track inspection platforms to identify broken railway/railroad spikes in real-time.
Described herein are cellular materials comprised of a 3D periodic network of beams with open-cell Kelvin foam (truncated octahedron) that have particular cross-sectional geometries that resist buckling while also suppressing failure of the base material when the cellular material is subjected to hydrostatic loading.
C04B 35/565 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides based on silicon carbide
66.
CHIRP-BASED OVER-THE-AIR COMPUTATION FOR PRIVACY-PRESERVING DISTRIBUTED LOCALIZATION
The disclosure deals with method and system for an over-the-air computation (OAC) approach for privacy-preserving localization in a sensor network. The disclosed approach relies on a voting-based distributed localization and the computation of the majority votes (MVs) with OAC. In this method, the anchor node (AN)'s votes encoding the potential location of a server node (SN) are mapped to a circularly-shifted chirp (CSC) signal and all AN simultaneously transmit their CSC signals. The aggregated signal is received at the SN and the MV votes are detected non-coherently without requiring an ideal time-synchronization or channel state information (CSI). We further disclose an iterative refinement procedure to increase the localization performance. The CSCs result in spectral-efficient and power-efficient transmission, while disclosed iterative refinements and repetitions decrease the gap between the root-mean-square error (RMSE) and the quantization bound.
The disclosure deals with methodology and system subject matter for a low-cost and portable millimeter-wave software-defined radio (SDR) which supports wireless experimentation in the 60 GHz band. The SDR uses a homodyne transceiver and provides a Transmission Control Protocol/Internet Protocol (TCP/IP)-based interface for companion computer (CC)-based baseband signal processing. To address the large difference between the processing speed of the CC and the sample rate of analog-to-digital converters, we use a disclosed method, called waveform-triggered reception (WTR), where a hard-coded block detects a special trigger waveform to acquire a predetermined number of in-phase/quadrature (IQ) data samples upon the detection. A buffer mechanism is used to support discontinuous transmissions. Using both the WTR and discontinuous transmissions, we can conduct a beam sweeping experiment, to evaluate 4096 beam pairs rapidly without compromising the flexibility of the CC-based processing.
H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
H04B 1/30 - Circuits for homodyne or synchrodyne receivers
68.
PHASE STABILIZED GROWTH OF MONOCLINIC-GALLIUM OXIDE ON THERMALLY CONDUCTING MATERIALS
Described herein are alternative uses of silicon for β-Ga2O3 MOCVD heteroepitaxy as a phase stabilizer in the form of silicon-oxygen (Si—O) bonding that provides thermal annealing for achieving smooth and thick monoclinic phase-pure gallium oxide (β-Ga2O3) on sapphire, which can provide β-Ga2O3 growth on thermally conductive hexagonal substrates, such as AlN, 4H—SiC, and 6H—SiC.
Described herein are methods of making, as well as self-biased UV photodetectors used to design self-powered UV sensors for harsh environment applications, e.g., advanced nuclear reactors and space missions, to provide wide bandgap semiconductors as high-efficiency self-biased UV photodetectors.
H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
Method and apparatus detect structural damage of structures using Acoustic Emission (AE) sensors. Using our method, structures can be monitored in real-time to predict damage level. This damage level assessment can be used to plan repairs and restorations of structures. Application can be used with concrete, and also applied to other materials such as composites. Predictive AE models may be tuned for determining structural damage zones, with the method extendable into any number of zones. An algorithm may be used in conjunction with decision tree filtering to use AE to predict structural damage zones, with the system able to perform analysis in real-time.
A mixer for mixing contents of a vessel includes a rotational mechanism with an attached gearbox. First and second shafts are coaxial with each other and attached to the gearbox. The gearbox is configured to rotate the first shaft and the second shaft in opposite directions. First and second rotors are rotated, respectively, in opposite directions by the first and second shafts. A housing encloses the gearbox and extends downward from the gearbox to just above the two contra-rotating first and second rotors (or impellers). The housing directs air (or other gas, liquid, or fluid) downward. Openings at the top of the housing admit air which is forced to the bottom of the housing by additional air impellers fastened to the outer of the two shafts. Lower housing openings allow aerated air to exit into desired material, such as fluid or solid/liquid mixture.
B01F 35/33 - TransmissionsMeans for modifying the speed or direction of rotation
B01F 27/191 - Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
B01F 27/2121 - Mixers with rotary stirring devices in fixed receptaclesKneaders characterised by their rotating shafts composed of interconnected parts
72.
AUTOMATIC CROSS DOCUMENT CONSOLIDATION AND VISUALIZATION OF DATA TABLES
In an embodiment, a set of related documents (105) is selected (305). Each document may include at least one table of data (107). The tables may not include semantic or structural data that can be used to understand the data in the tables. Each table is processed to determine a schema for the table that includes a name and type for each column of the table (320). A consolidated schema is received for a consolidated table (320). The consolidated schema includes a name and type for each column of the consolidated table. The data from each table is extracted from the table and added to the consolidated table based on the schema associated with the table and the schema associated with the consolidated table (325). Later, the data in the consolidated table can be visualized to help identify one or more trends (400).
Novel PBI films which may be used in electrochemical cells, such as redox flow batteries, are disclosed. Additionally, disclosed herein are membranes which comprise the novel PBI films which may be free from an organic solvent, and have a tensile strength at break of at least 25 MPa after drying.
Disclosed herein are methods for treating a subject comprising the administration of an effective amount of an inhibitor of CDK8 and CDK19 to a subject in need of a treatment for a cytokine storm or elevated amounts of a multiplicity of different cytokine-storm mediating cytokines.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
75.
TREATMENT REGIMENS AND METHODS OF USING QUERCETIN TO PREVENT AND/OR TREAT MUSCLE WASTING DISORDERS
Described herein are treatment regimens, therapies, pharmaceutical formulations and methods of using quercetin to prevent, treat, and/or protect from muscle wasting including 1) sarcopenia associated with aging; and 2) cachexia associated with chronic diseases and their treatments including but not limited to cancer, cardiovascular disease, chronic obstructive pulmonary disease (COPD), HIV, and kidney disease.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
An exemplary embodiment of the present disclosure provides a heterogeneous chemical catalyst comprising a substrate, a molecule attached to the substrate via a binding site, wherein the molecule comprises a catalytic active site, and a coating layer coating at least a portion of the binding site. Another embodiment of the present disclosure provides a method of preparing a heterogeneous chemical catalyst. This method comprises providing a substrate, attaching a molecule to the substrate via a binding site, wherein the molecule comprises a catalytic active site, and coating, with a coating layer, at least a portion of the binding site to form the heterogeneous chemical catalyst.
A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
In general, the present disclosure is directed to an endovascular device. The device may include an outer body comprising a biocompatible polymeric material; and a core comprising a first layer and a second layer, wherein the first layer comprising an anti-contractile agent and the second layer comprising a second agent.
In general, disclosed herein are methods for forming hydrogen by use of an ammonia decomposition catalyst system. For instance, a method can include contacting a catalyst system with an ammonia source at a temperature of about 450° C. or lower. The catalyst systems can include a support material and a trimetallic catalyst component carried on the support material and within a reactor. Disclosed catalyst systems can decompose ammonia at relatively low temperatures and can provide an efficient and cost-effective route to utilization of ammonia as a carbon-free hydrogen storage and generation material.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal Performances and art exhibits, live musical performances, and dance theatrical events.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Association services, namely, promoting the interests of alumni of the University of South Carolina Entertainment services, namely, conducting intercollegiate sporting events and football, track and field, men's and women's basketball, men's and women's soccer, softball, men's and women's golf, swimming, volleyball, beach volleyball, equestrian, and baseball games
A cannulation simulation device and methods for using the device are described. The device is designed to teach dialysis technicians/nurses or patients to cannulate arteriovenous (AV) fistulas for hemodialysis. The simulator includes one or more artificial fistulas. The simulator includes a pad of simulated flesh that can cover the artificial fistula(s). The pad can be reversed, rotated, and replaced with thicker or thinner pads. A personal simulation device for teaching self-cannulation can include a sleeve for a limb that can carry an artificial fistula. A clinical simulation device can include a plurality of artificial fistulas held in a support. Optionally, the artificial fistulas can vibrate to simulate an actual fistula.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events
86.
ODD CHAIN FATTY ACID THERAPY FOR THE TREATMENT OF MITOCHONDRIAL DISEASES
Methods disclosed herein are directed to treating a mitochondrial disorder in a subject. For instance, methods can be utilized to treat a mitochondrial disorder based on an amount of at least one metabolite measured in a biological sample of a subject.
In general, disclosed herein are methods of treating an inflammatory disease or disorder by administering to the subject in need thereof a polyacetylene compound. The polyacetylene compound may be administered at a dose of from about 1 mg/kg body weight to about 10 mg/kg body weight.
The disclosure deals with a system and method for improved representation and retrieval of recipes or workflows. Recipes or workflows such as for preparing food or assembling furniture or performing other complex activities exist as textual or image documents, which makes it difficult for machines to read, reason, and handle ambiguity. The present disclosure provides a Rich Recipe Representation (“R3”), which is enhanced with additional knowledge such as outcomes like allergen information, possible failures, and solutions for each atomic step (such as a cooking step). The disclosed R3 is used in a web-based decision support system that helps users perform constrained queries using multiple modalities while also monitoring execution of an agent cooking or otherwise acting based on it.
A system and method concerns accurate bearing fault diagnosis and prognosis (FDP), critical for optimal maintenance schedules, safety and reliability. Existing methods face challenges: the bearing condition is healthy in most of the service time, so it is critical to detect the occurrence of faults and the start point for prognosis in real applications. Due to differences in manufacturing quality, assembly quality, and different operating conditions, it is difficult to describe the fault dynamic using one single fault model. A hybrid Bayesian estimation-based bearing FDP framework with fault detection and automatic fault model selection is disclosed. A convolutional neural network is used to detect fault and select the appropriate fault dynamic model. To improve performance with different bearings under different operating conditions, continuous wavelet coefficient matrices power spectrum of vibration are fused with operating conditions to build information maps for fault detection and model selection. After a fault is detected, a Bayesian estimation based FDP method is triggered to estimate the fault state and predict the remaining useful life. In the prognostic process, Dempster-Shafer theory is employed to fuse prediction results from different models if necessary.
Described herein are systems and methods for the facile growth of aluminum gallium nitride semiconductor devices by utilizing specific lattice matched substrates. These substrates include metal borides, for example, ScB2, HfB2 and ZrB2 and metal carbides and metal nitrides. These substrates may allow for the cost effective manufacturing of ultra-wide bandgap semiconductor devices.
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 29/04 - Semiconductor bodies characterised by their crystalline structure, e.g. polycrystalline, cubic or particular orientation of crystalline planes
Described herein are drone designs, and methods for making same, wherein drones are constructed from interlocking modular nacelles of different types allowing nacelles to be added as needed to increase payload capacity, flight time, and mission capability as the application requires. The modular nacelles can be attached together into an aggregate structure, called a collective, as desired to yield an infinitely expandable and extensible drone. Since each nacelle includes its own battery, nacelles can be added as needed to achieve whatever capability is needed for the application at hand without having to customize the design of the drone.
Described herein are compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.
Methods for upgrading a bio-oil are described. The methods utilize gaseous ammonia to react with one or more components of a bio-oil and thereby upgrade the bio-oil and separate the resulting mixture into organic and aqueous phases. Both the aqueous phase and the organic phase produced by the process can contain useful species such as ammonium species and an organic phase with increased energy content as compared to the bio-oil.
Described herein is a high fidelity SFP Li-battery model, which can describe the internal electrochemical reaction mechanism accurately, to estimate State of Health (SOH) and State of Charge (SOC) of Li-batteries.
A general-purpose synchronization method allows a set of software-defined radios (SDRs) to transmit or receive any in-phase/quadrature (IQ) data with precise timings while maintaining the baseband processing in the corresponding companion computers (CCs). The presently disclosed method relies on the detection of a synchronization waveform in both receive and transmit directions and controlling the direct memory access (DMA) blocks jointly with the processing system. By implementing this synchronization method on a set of low-cost SDRs, the performance of frequency-shift keying (FSK)-based majority vote (MV) (FSK-MV) is demonstrated. Stated another way, the present disclosure relates to an over-the-air computation (OAC) scheme for federated edge learning (FEEL), and corresponding procedures. Demonstration shows that test accuracy can reach more than 95% for homogeneous and heterogeneous data distributions without using channel state information at the edge devices (EDs).
H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
96.
ASSIGNING TRUST RATING TO AI SERVICES USING CAUSAL IMPACT ANALYSIS
A method and system relates to assigning ratings (i.e., labels) to convey the trustability of AI systems grounded in its cause-and-effect behavior of significant inputs and outputs of the AI. Sentiment Analysis Systems (SASs) are data-driven Artificial Intelligence (AI) systems that, given a piece of text, assign a score conveying the sentiment and emotion intensity. The present disclosure uses the approach that protected attributes like gender and race influence the output (sentiment) given by SASs or if the sentiment is based on other components of the textual input, e.g., chosen emotion words. The presently disclosed rating methodology assigns ratings at fine-grained and overall levels, to rate SASs grounded in a causal setup, and provides an open-source implementation of both SASs—two deep-learning based, one lexicon-based, and two custom-built models—for this rating implementation. This allows users to understand the behavior of SAS in real-world applications.
Described herein are methods and systems for fabrication of high-performing metal-oxide-semiconductor (MOS) devices by depositing yttrium oxide epitaxial layers through pulsed laser deposition on high quality 4H—SiC epitaxial layers. The novel MOS devices revealed an extraordinarily long hole diffusion length that has never been reported. These devices have been investigated as radiation detectors which demonstrated an excellent radiation response at zero applied bias (self-biased) with a record-high energy resolution.
Described herein are cementitious composite materials incorporating carbon nanostructures (e.g., nanotubes, nanoplatelets, nanoribbons) that are employed as amendments (i.e., admixtures or additives) to cementitious waste forms as a means to enhance radionuclide and hazardous waste (e.g., heavy metals, toxic organics) retention wherein the incorporation of well-dispersed carbon nanostructures yields more effective waste forms through the resulting modification of the cementitious composite nano-, micro-, and meso-structure (e.g., hindering the infiltration of oxygen and the leaching of waste), and the chemical interactions between chemically-affine waste molecules and the amended cementitious composite.
C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
G21F 9/16 - Processing by fixation in stable solid media
A62D 3/33 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents by chemically fixing the harmful substance, e.g. by chelation or complexation
99.
COMPUTER-AIDED PROCESS PLANNING (CAPP) FOR AUTOMATED FIBER PLACEMENT (AFP) MANUFACTURING
Automated Fiber Placement (AFP) manufacturing with carbon fiber composites is increasingly used for complex and/or large structures. Computer-Aided Process Planning (CAPP) software supports process planning for AFP manufacturing to assist identifying optimal starting point location and layup strategy for each laminate ply. Ply optimization functions on measurement and scoring of geometry-based defects (gaps, overlaps, angle deviation, and steering). CAPP mitigates defect stacking through the laminate thickness by generating best ply scenarios and comparing ply defects to identify regions where defects are stacking up. Stacked defects frequency and severity are described using a disclosed scoring system, so process planners can craft fiber paths that mitigate the number and compounding effect of laminate geometry-based defects. Defects can be minimized in the process planning phase by optimizing the selection of input parameters such as starting points, layup strategies, and tows per course, using surrogate-based methods.
Evaluating railway ballast fouling condition is critical to assessing track conditions and arranging proper ballast maintenance. Because fouled ballast materials with different fouling conditions have different material properties, these properties can be used to evaluate the fouling severity. Various previously developed approaches to estimating fouling conditions often require special sensors or equipment, and well-trained technicians. Recently, convolutional neural network (CNN) based computer vision approaches have performed particle segmentation to obtain ballast grain size distribution. While the coarse aggregate fraction can be evaluated, many such approaches do not segment fine particles. This disclosure is an image analysis approach to directly estimate the ballast fouling conditions. First, fouled ballast images with different fouling conditions are taken as the reference. Then, the RGB color distributions of the fouled ballast images are processed through statistical analysis. A strong linear correlation between Fouling Index (FI) and Variance is found and used to establish an FI prediction model which has been tested and validated by additional fouled ballast samples.
