Ion exchange membranes and methods for forming the membranes are described. The ion exchange membranes can be incorporated in a redox flow battery. The membranes can exhibit high conductivity of desired ions (e.g., protons or hydroxide ions) as well as stability and durability in the redox flow battery environment while also exhibiting low permeability to redox couple species. The membranes are formed according to a polyphosphoric acid formation technique and subjected to a densification and thermal treatment.
A disclosed approximate tensor processing unit (APTPU) includes two main components: (1) approximate processing elements (APEs) consisting of a low-precision multiplier and an approximate adder, and (2) pre-approximate units (PAUs) which are shared among the APEs in the APTPU's systolic array, functioning as the steering logic to pre-process the operands and feed them to the APEs. Performance of the disclosed APTPU across various configurations and various workloads shows that the disclosed APTPU's systolic array achieves delay, area, and power reductions, while realizing comparable accuracy to previous designs.
G06F 15/80 - Architectures of general purpose stored program computers comprising an array of processing units with common control, e.g. single instruction multiple data processors
G06F 5/01 - Methods or arrangements for data conversion without changing the order or content of the data handled for shifting, e.g. justifying, scaling, normalising
3.
METHOD FOR THE REVIVAL OF MICROGLIA AND ASTROCYTES AND APPLICATIONS THEREOF
Methods are described for treatment of Alzheimer's Disease as well as other neurodegenerative disorders in which microglia and/or astrocyte abilities have been altered and impaired. Methods include brain-targeting of PD-L1 using a brain targeted nanogel loaded with PDL1 antibody and functionalized with two particular targeting ligands. The nanogels can successfully cross the blood brain barrier to release the antibody and reduce PD-L1 expression in the brain while preserving the integrity of the BBB.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
4.
Design of Acoustic Metamaterials Based on Liquid Crystal Skyrmions
The disclosure deals with a system and method for the design of acoustic metamaterials based on liquid crystal skyrmions. Noise attenuation, sound focusing, and harvesting acoustic wave energy are challenging issues that the technological community currently faces. The disclosed thermodynamically driven metamaterial facilitates the design of unique architectures with several acoustic applications, including sound attenuation and acoustic energy harvesting. This disclosed structure includes spherical shells in a hexagonal arrangement (or cubic), which can be designed in any size and additively manufactured for end use applications.
The disclosed system and methodology enable coexistence of networking and sensing on next-generation millimeter-wave (mmWave) picocells for traffic monitoring and pedestrian safety at intersections in all weather conditions. Existing wireless signal-based object detection systems suffer from limited resolution, and their outputs may not provide sufficient discriminatory information in complex scenes, such as traffic intersections. The disclosed system uses 5G picocells, which operate at mmWave frequency bands and provide higher data rates and higher sensing resolution than traditional wireless technology. It is difficult to run sensing applications and data transfer simultaneously on mmWave devices due to potential interference. MmWave devices are vulnerable to weak reflectivity and specularity challenges which may result in loss of information about objects and pedestrians. To address such challenges, the disclosed design uses customized deep learning models that not only can recover missing information about the target scene but also enable coexistence of networking and sensing.
A catalyst support containing praseodymium oxide and dysprosium oxide, supported catalysts using the support, and methods of using the supported catalysts to catalyze the formation and degradation of ammonia.
A catalyst including ruthenium, a promoter metal, and a second metal, optionally disposed on a support, and methods of using the catalyst to catalyze the formation of ammonia.
Described herein is an over-the-air computation (OAC) scheme for a federated k-means clustering algorithm to reduce the per-round communication latency when implemented over a wireless network. The OAC scheme relies on an encoder exploiting the representation of a number in a balanced number system and computes the sum of the updates for the federated k-means via signal superposition property of wireless multiple-access channels non-coherently to eliminate the need for precise phase and time synchronization.
A sea going instrument is used to measure the 234Th activity on settling particles in the ocean as an indicator of carbon sequestration as export from the surface ocean. The instrumentation can be adapted to multiple sampling platforms with the goal of providing high temporal resolution 234Th flux measurements at multiple locations and depths in the ocean. This proxy of mass flux is used to complement other in situ sensors to provide high resolution data for features such as Chlorophyll-a concentration (Chla), accessory pigments, and PIC normalized to mass flux.
G01T 1/178 - Circuit arrangements not adapted to a particular type of detector for measuring specific activity in the presence of other radioactive substances, e.g. natural, in the air or in liquids such as rain-water
G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state
Disclosed herein are methods, compositions, and kits for treating a subject in need of a treatment for a cancer. The method comprises administering to the subject a CDK8/19 inhibitor and a mTOR inhibitor.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
The disclosure relates to methodology and apparatus for a non-coherent over-the-air computation (OAC) methodology to calculate the majority vote (MV) reliably in fading channel. The disclosed approach relies on modulating the amplitude of the elements of complementary sequences (CSs) based on the sign of the parameters to be aggregated. Since the disclosed method does not use channel state information at the nodes, it is compatible with time-varying channels. The methodology is useful for an unmanned aerial vehicle (UAV) guided by distributed sensors based on the MV computed with the method. The method improves the computation error rate with a longer sequence length in fading channel while maintaining the peak-to-mean-envelope power ratio of the transmitted orthogonal frequency division multiplexing signals to be less than or equal to 3 dB.
H04W 24/02 - Arrangements for optimising operational condition
H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
Massively parallel systems and methods are described suitable for high throughput and large-scale production of highly consistent nanoparticles. The systems include a device that utilizes a single pump to pump a reaction mixture simultaneously through multiple formation channels. One or more devices can be utilized in a single production line, and a system can include multiple production lines. A device of a system provides essentially identical interaction conditions throughout the multiple channels with highly controllable and consistent pumping conditions to provide well-controlled and consistent flow conditions in the channels. This consistency allows for well-defined reaction formation chemistry and thereby provides highly consistent nanoparticle products in large quantities in a short time period.
A hyperspectral imaging apparatus based on a monolithic or free space optical spatial heterodyne spectrometer (SHS) design, array detector, electromagnetic radiation source, and optical collection element is described. The apparatus enables the simultaneous acquisition of spatially isolated Fizeau fringe patterns, each having an encoded light product that is decoded to produce a spectral fingerprint of the interrogated object. Features specific to the SHS, such as a large entrance aperture, large acceptance angle, and no moving parts, enable a variety of optical collection schemes including lens arrays, solid-core and hollow core waveguides, and others. In one example, a microlens array (MLA) is configured with the hyperspectral imaging apparatus to simultaneously image many hundred spatially isolated Fizeau fringe patterns while interrogating an object using an electromagnetic radiation source. Each Fizeau fringe pattern recorded by the array detector is decoded to produce a full Raman or laser-induced breakdown spectroscopy (LIBS) spectrum. Compared to prior art, the hyperspectral imaging apparatus overcomes the primary limitations of needing to trade time resolution for both spectral and spatial data density because the imaging apparatus simultaneously acquires both spectral and special information. Based on the selection and configuration of diffraction gratings, the grating aperture size, Littrow wavelength (i.e., heterodyne wavelength), and optical collection configuration, the apparatus can be tailored to produced low or high spectral resolution with a spectral bandpass that covers a portion or the entire Raman spectral range (up to 4200 cm−1) and for LIBS as well.
Methodology and corresponding apparatus pertain to human sleep posture monitoring, using a wireless signal-based monitoring system leveraging millimeter-wave technology. A software-only human sleep posture monitoring solution based on millimeter-wave (mmWave) wireless-based solutions enables fine-grained posture monitoring under no light without being privacy-invasive. In zero visibility, body joint information and changes can be extracted directly from mmWave imaging using improved capabilities for extracting human sleep posture data from millimeter-wave wireless systems. A single-person sleep posture monitoring system leverages signal processing and deep learning models to enable fine-grained monitoring continuously and non-intrusively with commodity (i.e., generally available) mmWave devices. The system directly predicts joint locations from reflected mmWave signals by learning the hidden association between them from thousands of data samples. Learning is accomplished through a customized Deep Convolutional Neural Network (DCNN), that predicts the 3D locations of several key body joints from the reflected signals captured by multiple mmWave antennas.
Described herein are methods, systems, and pharmaceutical compositions for using Trigonelline (TRG), an alkaloid found in the seeds of many plants, including coffee beans, to attenuate Spike-protein exacerbated lipotoxicity and mitochondria stress in endothelial cells and cardiomyocytes to protect the heart from injuries caused by SARS-CoV-2 Spike protein under obesity.
Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies. The disclosure also provides an oral dosage form comprising an amount of resveratrol comprising a therapeutically effective amount of cis-resveratrol and not more than 200 mg of trans-resveratrol.
Described herein are mobile nuclear micro-reactors, systems for same, as well as methods of making mobile nuclear micro-reactors in the hundreds of kilowatt range, scalable to higher powers, capable of operating, at least, ten years without refueling while designed to eliminate fuel resupply tails that have proven so costly in conflicts over the past two decades or more.
G21C 7/08 - Control of nuclear reaction by application of neutron-absorbing material, i.e. material with absorption cross-section very much in excess of reflection cross-section by displacement of solid control elements, e.g. control rods
G21C 7/103 - Control assemblies containing one or more absorbants as well as other elements, e.g. fuel or moderator elements
Described herein are systems and methods for secure and usable authentication techniques for drone delivery that leverages biometric information of faces, unlike traditional biometrics-based approaches, it does not need users to enroll their biometric information and is impervious to common drone attacks.
The disclosure deals with methodology and involved or associated systems for using infrared technology to detect tissue damage below the skin. Pressure and shear stress can damage the microvascular structure below the skin, which is not visible to the naked eye. Infrared thermography is a non-invasive mechanism to measure skin temperature via thermal radiation. Changes (restrictions) in blood flow below the skin can result in microvascular damage to the tissue, and directly impact skin temperature, which can be detected by infrared thermography. Infrared thermography can detect these changes at the site of tissue damage. This disclosure uses affordable infrared thermography to detect changes in temperature related to blood flow alterations, supported with AI. Using serial images, AI can detect an emerging DFU (Diabetic Foot Ulcer) in DM (Diabetes Mellitus) patients through deviations in skin temperature.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
21.
SLEEP DISRUPTIONS IDENTIFICATION FROM MILLIMETER-WAVE WIRELESS SYSTEMS
Methodology and corresponding apparatus pertains to sleep disruption monitoring, including use of a wireless signal-based monitoring system leveraging millimeter-wave technology. A software-only sleep disruption monitoring solution can be based on millimeter-wave (mmWave) wireless-based solutions which leverage cross-correlation between successive mmWave reflected signals and a Hidden Markov Model (HMM) to identify respective sleep (rest) and disruptions (toss-turn) periods. A toss-turn detector module can identify sudden movements during sleep from mmWave wireless signals and classify the sleeping period into the two states: Rest or toss-turn. Whenever mmWave transceivers (such as included in 5G-and-beyond devices) are implemented as access points, in mass privacy non-invasive sleep disruption monitoring can be provided for consumers at home.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
22.
STRONG POLYBENZIMIDAZOLE (PBI) GEL MEMBRANES WITH HIGH CONDUCTIVITY
Disclosed are polybenzimidazole gel membranes that exhibit both high proton conductivity and high tensile strength at break. The membranes are formed with a high percentage of tetraaminobiphenyl monomers and naphthalene dicarboxylic acid monomers.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Downloadable electronic publications in the nature of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators. Printed publications, namely, reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators. Educational services, namely, the publication of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators; research services, namely, providing education research services for use in the development of reports and white papers in the fields of policy research concerning the education, training, recruitment and retention of educators.
CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS – CNPEM (Brazil)
Inventor
D'Antonio, Edward L.
Mercaldi, Gustavo F.
Abstract
Colorimetric based high-throughput assay systems are described that utilize colorimetric agents that exhibit both high water solubility characteristics in both an oxidized and a reduced state and exhibit intense UV/vis absorption in only one of the oxidized or reduced states, with absorption in the other state being either non-existent or very low. Disclosed assays are useful in examining the efficacy of enzyme inhibitors, including helicase or kinase inhibitors.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
C12N 9/99 - Enzyme inactivation by chemical treatment
C12Q 1/32 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving dehydrogenase
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
25.
PIEZOELECTRIC ACOUSTIC BIOSENSOR AND USES THEREFORE
Disclosed is an acoustic-based biosensing platform that can be utilized in point of care applications and can provide rapid results with both high sensitivity and high selectivity. The sensing platform includes a plurality of piezoelectric cantilevers conjugated with a specific binding member for a bioanalyte of interest. Upon excitation of an excitation cantilever, acoustic feature extraction from response signals can provide information with regard to the presence or quantity of a bioanalyte of interest.
H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
Cellulose-based scaffolds for enzyme immobilization and methods for forming and using the scaffolds are described. The scaffolds incorporate delignified bamboo that can be functionalized to include an enzyme immobilized at a surface of the delignified bamboo via an alkylamine linkage. Disclosed scaffolds can be utilized in enzyme-based flow bioreactors.
Method and system subject matter deals with predicting delirium in patients. As many as 80% of critically ill patients develop delirium increasing the need for institutionalization and resulting in higher morbidity and mortality. Clinicians detect less than 40% of delirium when using a validated screening tool. EEG is the criterion standard but is resource intensive thus not feasible for widespread delirium monitoring. This disclosure uses limited-lead rapid-response EEG and supervised deep learning methods with vision transformer to predict delirium. Vision transformer with rapid-response EEG is capable of predicting delirium. Such monitoring is feasible in critically ill older adults, for improving delirium detection accuracy, and providing greater opportunity for individualized interventions. Benefits may shorten hospital length of stay, increase discharge to home, decrease mortality, and reduce the financial burden associated with delirium.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/256 - Wearable electrodes, e.g. having straps or bands
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
28.
Mechanism and methods for robotic installation of stakes
An autonomous all-terrain robot for agricultural industries is designed to install support stakes inground on plant beds while being able to self-navigate. Apparatus and method provide a robot having the ability to perform the actions of navigating between plant beds and to determine a precise location and depth to place each supporting stake. The purpose of the stakes is to support the plants with weak stems. Part of some planting processes require stakes to support a plant as it begins to grow. from a two- or three-week-old plant to a fully mature plant. The presently disclosed subject matter provides a machine that can aid in the planting process of both bell peppers and eggplants and similar crops, used to drive stakes into planting beds. The presently disclosed technology (such as specific robotic device or robot) can work 24/7, weather permitting, while providing an efficient and completely hands-free way to install stakes needed in the planting process.
Disclosed are brain-targeted antibody delivery systems, methods of forming the systems, and methods of using the systems. The systems include hydrophilic nanogels based upon poly(ethylene glycol) copolymers. The nanogels can encapsulate an antibody for delivery to the brain and can include ligands for blood brain barrier (BBB) receptors on the surface, and as such, can utilize a systemic route of administration for delivery of the antibody to the brain and the eye. The systems can be utilized for systemic delivery routes to deliver the antibody to the brain side of the blood brain barrier and inside glial cells and degrade its corresponding protein. The systems can be utilized in treatment of neurodegenerative or retinal disorders.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
30.
SYSTEM AND METHOD TO MEDIATE SOCIAL MEDIA PLATFORMS AUTOMATICALLY FOR USER SAFETY
The disclosure deals with a system and method for mediating social media platforms automatically for user safety, including in particular for automatically or semi-automatically mediating social media platforms for user safety. People meet on online platforms and discuss a variety of topics. Moderators associated with those platforms play an important role in making the platform convenient and safe to users. This disclosure addresses detecting users who can act as potential moderators of an online group of support seekers and support providers in an online social media platform operating on the Internet. Such users are classified to identify the class of supportive users and class of non-supportive users of an online group. Received suggestions and other acquired data are used to identify a potential moderator for the online group. Acquired data on supportive and non-supportive users, as well as on harmful users, is then automatically supplied to the moderator.
H04L 51/52 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail for supporting social networking services
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
Described herein are methods, systems, and processes for in-situ oxide dielectric deposition in the same reactor, integrating III-Nitride and III-Oxide technology using N2 as carrier gas that results in a lower density of interface traps (charges).
Described herein are a low-cost, non-destructive, and contact-free intelligent inspection system that is field-deployable on a geometry car, high-rail vehicle, or other types of track inspection platforms to identify broken railway/railroad spikes in real-time.
Described herein are cellular materials comprised of a 3D periodic network of beams with open-cell Kelvin foam (truncated octahedron) that have particular cross-sectional geometries that resist buckling while also suppressing failure of the base material when the cellular material is subjected to hydrostatic loading.
C04B 35/565 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides based on silicon carbide
34.
WAVEFORM-TRIGGERED RECEPTION AND BUFFERING FOR MILLIMETER-WAVE SOFTWARE-DEFINED RADIOS
The disclosure deals with methodology and system subject matter for a low-cost and portable millimeter-wave software-defined radio (SDR) which supports wireless experimentation in the 60 GHz band. The SDR uses a homodyne transceiver and provides a Transmission Control Protocol/Internet Protocol (TCP/IP)-based interface for companion computer (CC)-based baseband signal processing. To address the large difference between the processing speed of the CC and the sample rate of analog-to-digital converters, we use a disclosed method, called waveform-triggered reception (WTR), where a hard-coded block detects a special trigger waveform to acquire a predetermined number of in-phase/quadrature (IQ) data samples upon the detection. A buffer mechanism is used to support discontinuous transmissions. Using both the WTR and discontinuous transmissions, we can conduct a beam sweeping experiment, to evaluate 4096 beam pairs rapidly without compromising the flexibility of the CC-based processing.
H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
H04B 1/30 - Circuits for homodyne or synchrodyne receivers
35.
PHASE STABILIZED GROWTH OF MONOCLINIC-GALLIUM OXIDE ON THERMALLY CONDUCTING MATERIALS
Described herein are alternative uses of silicon for β-Ga2O3 MOCVD heteroepitaxy as a phase stabilizer in the form of silicon-oxygen (Si—O) bonding that provides thermal annealing for achieving smooth and thick monoclinic phase-pure gallium oxide (β-Ga2O3) on sapphire, which can provide β-Ga2O3 growth on thermally conductive hexagonal substrates, such as AlN, 4H—SiC, and 6H—SiC.
Described herein are methods of making, as well as self-biased UV photodetectors used to design self-powered UV sensors for harsh environment applications, e.g., advanced nuclear reactors and space missions, to provide wide bandgap semiconductors as high-efficiency self-biased UV photodetectors.
H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
The disclosure deals with method and system for an over-the-air computation (OAC) approach for privacy-preserving localization in a sensor network. The disclosed approach relies on a voting-based distributed localization and the computation of the majority votes (MVs) with OAC. In this method, the anchor node (AN)'s votes encoding the potential location of a server node (SN) are mapped to a circularly-shifted chirp (CSC) signal and all AN simultaneously transmit their CSC signals. The aggregated signal is received at the SN and the MV votes are detected non-coherently without requiring an ideal time-synchronization or channel state information (CSI). We further disclose an iterative refinement procedure to increase the localization performance. The CSCs result in spectral-efficient and power-efficient transmission, while disclosed iterative refinements and repetitions decrease the gap between the root-mean-square error (RMSE) and the quantization bound.
Method and apparatus detect structural damage of structures using Acoustic Emission (AE) sensors. Using our method, structures can be monitored in real-time to predict damage level. This damage level assessment can be used to plan repairs and restorations of structures. Application can be used with concrete, and also applied to other materials such as composites. Predictive AE models may be tuned for determining structural damage zones, with the method extendable into any number of zones. An algorithm may be used in conjunction with decision tree filtering to use AE to predict structural damage zones, with the system able to perform analysis in real-time.
A mixer for mixing contents of a vessel includes a rotational mechanism with an attached gearbox. First and second shafts are coaxial with each other and attached to the gearbox. The gearbox is configured to rotate the first shaft and the second shaft in opposite directions. First and second rotors are rotated, respectively, in opposite directions by the first and second shafts. A housing encloses the gearbox and extends downward from the gearbox to just above the two contra-rotating first and second rotors (or impellers). The housing directs air (or other gas, liquid, or fluid) downward. Openings at the top of the housing admit air which is forced to the bottom of the housing by additional air impellers fastened to the outer of the two shafts. Lower housing openings allow aerated air to exit into desired material, such as fluid or solid/liquid mixture.
B01F 35/33 - TransmissionsMeans for modifying the speed or direction of rotation
B01F 27/191 - Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
B01F 27/2121 - Mixers with rotary stirring devices in fixed receptaclesKneaders characterised by their rotating shafts composed of interconnected parts
40.
AUTOMATIC CROSS DOCUMENT CONSOLIDATION AND VISUALIZATION OF DATA TABLES
In an embodiment, a set of related documents (105) is selected (305). Each document may include at least one table of data (107). The tables may not include semantic or structural data that can be used to understand the data in the tables. Each table is processed to determine a schema for the table that includes a name and type for each column of the table (320). A consolidated schema is received for a consolidated table (320). The consolidated schema includes a name and type for each column of the consolidated table. The data from each table is extracted from the table and added to the consolidated table based on the schema associated with the table and the schema associated with the consolidated table (325). Later, the data in the consolidated table can be visualized to help identify one or more trends (400).
Disclosed herein are methods for treating a subject comprising the administration of an effective amount of an inhibitor of CDK8 and CDK19 to a subject in need of a treatment for a cytokine storm or elevated amounts of a multiplicity of different cytokine-storm mediating cytokines.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
Novel PBI films which may be used in electrochemical cells, such as redox flow batteries, are disclosed. Additionally, disclosed herein are membranes which comprise the novel PBI films which may be free from an organic solvent, and have a tensile strength at break of at least 25 MPa after drying.
Described herein are treatment regimens, therapies, pharmaceutical formulations and methods of using quercetin to prevent, treat, and/or protect from muscle wasting including 1) sarcopenia associated with aging; and 2) cachexia associated with chronic diseases and their treatments including but not limited to cancer, cardiovascular disease, chronic obstructive pulmonary disease (COPD), HIV, and kidney disease.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
An exemplary embodiment of the present disclosure provides a heterogeneous chemical catalyst comprising a substrate, a molecule attached to the substrate via a binding site, wherein the molecule comprises a catalytic active site, and a coating layer coating at least a portion of the binding site. Another embodiment of the present disclosure provides a method of preparing a heterogeneous chemical catalyst. This method comprises providing a substrate, attaching a molecule to the substrate via a binding site, wherein the molecule comprises a catalytic active site, and coating, with a coating layer, at least a portion of the binding site to form the heterogeneous chemical catalyst.
A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
In general, the present disclosure is directed to an endovascular device. The device may include an outer body comprising a biocompatible polymeric material; and a core comprising a first layer and a second layer, wherein the first layer comprising an anti-contractile agent and the second layer comprising a second agent.
In general, disclosed herein are methods for forming hydrogen by use of an ammonia decomposition catalyst system. For instance, a method can include contacting a catalyst system with an ammonia source at a temperature of about 450° C. or lower. The catalyst systems can include a support material and a trimetallic catalyst component carried on the support material and within a reactor. Disclosed catalyst systems can decompose ammonia at relatively low temperatures and can provide an efficient and cost-effective route to utilization of ammonia as a carbon-free hydrogen storage and generation material.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal Performances and art exhibits, live musical performances, and dance theatrical events.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions, theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Association services, namely, promoting the interests of alumni of the University of South Carolina Entertainment services, namely, conducting intercollegiate sporting events and games
A cannulation simulation device and methods for using the device are described. The device is designed to teach dialysis technicians/nurses or patients to cannulate arteriovenous (AV) fistulas for hemodialysis. The simulator includes one or more artificial fistulas. The simulator includes a pad of simulated flesh that can cover the artificial fistula(s). The pad can be reversed, rotated, and replaced with thicker or thinner pads. A personal simulation device for teaching self-cannulation can include a sleeve for a limb that can carry an artificial fistula. A clinical simulation device can include a plurality of artificial fistulas held in a support. Optionally, the artificial fistulas can vibrate to simulate an actual fistula.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing classes, courses and seminars at the undergraduate, post-graduate, and continuing adult education levels and professional levels; Continuing educational services, namely, providing classes, courses and seminars at the continuing professional level in the field of Spanish translation, innovation in business process and crime analysis; Entertainment services, namely, conducting cultural events namely, fine art productions theatre productions, vocal performances and art exhibits, live musical performances, and dance theatrical events
54.
POLYACETYLENE COMPOUNDS FOR TREATING INFLAMMATORY DISEASES
In general, disclosed herein are methods of treating an inflammatory disease or disorder by administering to the subject in need thereof a polyacetylene compound. The polyacetylene compound may be administered at a dose of from about 1 mg/kg body weight to about 10 mg/kg body weight.
Methods disclosed herein are directed to treating a mitochondrial disorder in a subject. For instance, methods can be utilized to treat a mitochondrial disorder based on an amount of at least one metabolite measured in a biological sample of a subject.
The disclosure deals with a system and method for improved representation and retrieval of recipes or workflows. Recipes or workflows such as for preparing food or assembling furniture or performing other complex activities exist as textual or image documents, which makes it difficult for machines to read, reason, and handle ambiguity. The present disclosure provides a Rich Recipe Representation (“R3”), which is enhanced with additional knowledge such as outcomes like allergen information, possible failures, and solutions for each atomic step (such as a cooking step). The disclosed R3 is used in a web-based decision support system that helps users perform constrained queries using multiple modalities while also monitoring execution of an agent cooking or otherwise acting based on it.
A system and method concerns accurate bearing fault diagnosis and prognosis (FDP), critical for optimal maintenance schedules, safety and reliability. Existing methods face challenges: the bearing condition is healthy in most of the service time, so it is critical to detect the occurrence of faults and the start point for prognosis in real applications. Due to differences in manufacturing quality, assembly quality, and different operating conditions, it is difficult to describe the fault dynamic using one single fault model. A hybrid Bayesian estimation-based bearing FDP framework with fault detection and automatic fault model selection is disclosed. A convolutional neural network is used to detect fault and select the appropriate fault dynamic model. To improve performance with different bearings under different operating conditions, continuous wavelet coefficient matrices power spectrum of vibration are fused with operating conditions to build information maps for fault detection and model selection. After a fault is detected, a Bayesian estimation based FDP method is triggered to estimate the fault state and predict the remaining useful life. In the prognostic process, Dempster-Shafer theory is employed to fuse prediction results from different models if necessary.
Described herein are systems and methods for the facile growth of aluminum gallium nitride semiconductor devices by utilizing specific lattice matched substrates. These substrates include metal borides, for example, ScB2, HfB2 and ZrB2 and metal carbides and metal nitrides. These substrates may allow for the cost effective manufacturing of ultra-wide bandgap semiconductor devices.
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 29/04 - Semiconductor bodies characterised by their crystalline structure, e.g. polycrystalline, cubic or particular orientation of crystalline planes
Described herein are compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 μM, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.
Methods for upgrading a bio-oil are described. The methods utilize gaseous ammonia to react with one or more components of a bio-oil and thereby upgrade the bio-oil and separate the resulting mixture into organic and aqueous phases. Both the aqueous phase and the organic phase produced by the process can contain useful species such as ammonium species and an organic phase with increased energy content as compared to the bio-oil.
Described herein are drone designs, and methods for making same, wherein drones are constructed from interlocking modular nacelles of different types allowing nacelles to be added as needed to increase payload capacity, flight time, and mission capability as the application requires. The modular nacelles can be attached together into an aggregate structure, called a collective, as desired to yield an infinitely expandable and extensible drone. Since each nacelle includes its own battery, nacelles can be added as needed to achieve whatever capability is needed for the application at hand without having to customize the design of the drone.
Described herein is a high fidelity SFP Li-battery model, which can describe the internal electrochemical reaction mechanism accurately, to estimate State of Health (SOH) and State of Charge (SOC) of Li-batteries.
A general-purpose synchronization method allows a set of software-defined radios (SDRs) to transmit or receive any in-phase/quadrature (IQ) data with precise timings while maintaining the baseband processing in the corresponding companion computers (CCs). The presently disclosed method relies on the detection of a synchronization waveform in both receive and transmit directions and controlling the direct memory access (DMA) blocks jointly with the processing system. By implementing this synchronization method on a set of low-cost SDRs, the performance of frequency-shift keying (FSK)-based majority vote (MV) (FSK-MV) is demonstrated. Stated another way, the present disclosure relates to an over-the-air computation (OAC) scheme for federated edge learning (FEEL), and corresponding procedures. Demonstration shows that test accuracy can reach more than 95% for homogeneous and heterogeneous data distributions without using channel state information at the edge devices (EDs).
H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
64.
ASSIGNING TRUST RATING TO AI SERVICES USING CAUSAL IMPACT ANALYSIS
A method and system relates to assigning ratings (i.e., labels) to convey the trustability of AI systems grounded in its cause-and-effect behavior of significant inputs and outputs of the AI. Sentiment Analysis Systems (SASs) are data-driven Artificial Intelligence (AI) systems that, given a piece of text, assign a score conveying the sentiment and emotion intensity. The present disclosure uses the approach that protected attributes like gender and race influence the output (sentiment) given by SASs or if the sentiment is based on other components of the textual input, e.g., chosen emotion words. The presently disclosed rating methodology assigns ratings at fine-grained and overall levels, to rate SASs grounded in a causal setup, and provides an open-source implementation of both SASs—two deep-learning based, one lexicon-based, and two custom-built models—for this rating implementation. This allows users to understand the behavior of SAS in real-world applications.
Described herein are methods and systems for fabrication of high-performing metal-oxide-semiconductor (MOS) devices by depositing yttrium oxide epitaxial layers through pulsed laser deposition on high quality 4H—SiC epitaxial layers. The novel MOS devices revealed an extraordinarily long hole diffusion length that has never been reported. These devices have been investigated as radiation detectors which demonstrated an excellent radiation response at zero applied bias (self-biased) with a record-high energy resolution.
Described herein are cementitious composite materials incorporating carbon nanostructures (e.g., nanotubes, nanoplatelets, nanoribbons) that are employed as amendments (i.e., admixtures or additives) to cementitious waste forms as a means to enhance radionuclide and hazardous waste (e.g., heavy metals, toxic organics) retention wherein the incorporation of well-dispersed carbon nanostructures yields more effective waste forms through the resulting modification of the cementitious composite nano-, micro-, and meso-structure (e.g., hindering the infiltration of oxygen and the leaching of waste), and the chemical interactions between chemically-affine waste molecules and the amended cementitious composite.
C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
G21F 9/16 - Processing by fixation in stable solid media
A62D 3/33 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents by chemically fixing the harmful substance, e.g. by chelation or complexation
67.
COMPUTER-AIDED PROCESS PLANNING (CAPP) FOR AUTOMATED FIBER PLACEMENT (AFP) MANUFACTURING
Automated Fiber Placement (AFP) manufacturing with carbon fiber composites is increasingly used for complex and/or large structures. Computer-Aided Process Planning (CAPP) software supports process planning for AFP manufacturing to assist identifying optimal starting point location and layup strategy for each laminate ply. Ply optimization functions on measurement and scoring of geometry-based defects (gaps, overlaps, angle deviation, and steering). CAPP mitigates defect stacking through the laminate thickness by generating best ply scenarios and comparing ply defects to identify regions where defects are stacking up. Stacked defects frequency and severity are described using a disclosed scoring system, so process planners can craft fiber paths that mitigate the number and compounding effect of laminate geometry-based defects. Defects can be minimized in the process planning phase by optimizing the selection of input parameters such as starting points, layup strategies, and tows per course, using surrogate-based methods.
Evaluating railway ballast fouling condition is critical to assessing track conditions and arranging proper ballast maintenance. Because fouled ballast materials with different fouling conditions have different material properties, these properties can be used to evaluate the fouling severity. Various previously developed approaches to estimating fouling conditions often require special sensors or equipment, and well-trained technicians. Recently, convolutional neural network (CNN) based computer vision approaches have performed particle segmentation to obtain ballast grain size distribution. While the coarse aggregate fraction can be evaluated, many such approaches do not segment fine particles. This disclosure is an image analysis approach to directly estimate the ballast fouling conditions. First, fouled ballast images with different fouling conditions are taken as the reference. Then, the RGB color distributions of the fouled ballast images are processed through statistical analysis. A strong linear correlation between Fouling Index (FI) and Variance is found and used to establish an FI prediction model which has been tested and validated by additional fouled ballast samples.
A digital over-the-air computation (OAC) scheme achieves continuous-valued (analog) aggregation for federated edge learning (FEEL). The average of a set of real-valued parameters can be calculated approximately by using the average of the corresponding numerals, where the numerals are obtained based on a balanced number system. By exploiting this key property, local stochastic gradients are encoded into a set of numerals. Next, positions of the activated orthogonal frequency division multiplexing (OFDM) subcarriers are determined by using the values of the numerals. To eliminate the need for a precise sample-level time synchronization, channel estimation overhead, and power instabilities due to the channel inversion, a non-coherent receiver is used at the edge server (ES) and pre-equalization at the edge devices (EDs) is not used. To improve the test accuracy of FEEL with the presently disclosed method, we introduce the concept of adaptive absolute maximum (AAM). Numerical results show test accuracy can reach up to 98% for heterogeneous data distribution using presently disclosed scheme with AAM for FEEL.
Methods disclosed herein are directed to methods of detecting and/or quantifying an antigen. The ultrasensitive Click chemistry Amplified Nanopore (CAN) assay has been engineered for antigen quantification in a biological sample. According to the present disclosure, the CAN assay is based on the combination of an amplified sandwich assay and nanopore sensing. Methods disclosed herein may be incorporated into a point-of-care test device with the necessary accuracy, portability, cost efficiency, and simplicity to fill the diagnostic gaps in high infectious disease burden areas.
The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
72.
In-contact Continuous Temperature Measurement Probe for Non-insulated Electric-Current Carrying Conductor
An in-contact temperature measurement probe, which can measure temperature accurately on the surface of a current carrying wire, rod, heater, or other device, while maintaining the safety of the user via employing non-electrically conductive but thermally conductive materials.
G01K 7/04 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples the object to be measured not forming one of the thermoelectric materials
H10N 10/00 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects
H10N 10/10 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects
H10N 10/17 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects operating with only the Peltier or Seebeck effects characterised by the structure or configuration of the cell or thermocouple forming the device
73.
SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of
For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.
C07C 233/81 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C07C 235/84 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 233/66 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
C07C 233/80 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
The disclosure deals with a system and method for inducing sleep loss in animal test subjects, such as rats. A sleep deprivation chamber uses a DC Servo motor with a controller to cause a bar to sweep across the rodent cage floor. The system is programmed to sweep the bar across the floor of the rodent cage at varying intervals. The maximum speed at which the bar sweeps the entire rodent cage is within 3 seconds. The chamber is designed such that it can structurally accommodate a receiver and record EEG/EMG telemetrically in animals that have been implanted with sleep transmitters. During the sleep deprivation protocol, food and water are available to animals in the chamber at all times. The chamber is also designed to fit a standardized rodent (e.g., rat or mouse) cage, and plural cages such as an 8-chamber sleep restriction device can be simultaneously operated.
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
Methods are provided for using a combination of nanomaterials and oil-degrading bacteria to detoxify a multiphasic liquid (e.g., an oil-water mixture) and to ameliorate the toxicity of oil to local organisms, e.g., meiobenthos, in or near the area of the multiphasic liquid. The methods can be utilized for oil recovery and environmental clean-up and detoxification after spills and discharges. Through synergistic combination of the nanomaterials with oil degrading bacteria, methods can ameliorate environmental damage due to the presence of oil in an area through increased activation of the bacteria as well as through removal of the oil.
C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
A new vibration test-cell that allows a static load to be applied simultaneously with lateral vibration coupled with in-situ microscopy that allows for the ability to open a fatigue crack up to a desired gap, as well as generate acoustic emission (AE) from vibration excitation, micro-fracture events are captured by the AE measurement while the physical observation of the crack faying surfaces is performed in-situ with an optical microscope embedded in the test cell.
The disclosure deals with a system and method for Compressive Sensing, which has been shown to greatly reduce data acquisition and processing burdens by providing mathematical guarantees for accurate signal recovery from far fewer samples than conventionally needed. A generalized Compressive Sensing methodology developed for automated reduction of non-destructive evaluation/structural health monitoring (NDE/SHM) data is effective for multiple types of NDE/SHM systems. The methodology uses Compressive Sensing at two stages in the data acquisition and analysis process to detect damage. The two stages are: (1) temporally undersampled sensor signals from (2) spatially undersampled sensor arrays, resulting in faster data acquisition and reduced data sets without any loss in damage detection ability. In addition, a graphical user interface helps guide and visualize the associated data reconstruction process.
In the past, several microchannel configurations were developed to realize two-phase cooling for high-power electronics, but these were limited to small devices with sizes at ˜cm length. It has been a challenge to implement effective two-phase cooling to large devices with a length of ˜10 cm due to notorious scaling effects. Here, we devised a novel channel configuration to achieve effective two-phase cooling on devices with an area of ˜10 cm by ˜5 cm or larger, which is the prevailing size of major commercial electronics and power electronics devices. In a lab environment, we demonstrated that the novel channel configuration can meet their cooling needs.
Disclosed methodology assesses the existence of disparate impact in internet markets that serve geographically dispersed consumers. Implementations of the method can collect unbiased offering (e.g., pricing and/or other fees and costs) data for a large number of products and geographic areas, so that marketing decisions, such as price, recommendations, and delivery fees can be matched to consumer demographic data from established sources such as censuses and large scale surveys. The combined data can then be used to investigate the presence and nature of disparate impact and can be used by internet platforms and retailers to audit their algorithms for disparate impact without collecting or holding the demographic data of their own users. Thus, a methodology is provided for the collection of data required to study the extent to which algorithms in internet markets may induce disparities across demographic consumer groups and whether disparities can be justified by valid interests.
Chemically inert, mechanically tough, cationic metallo-polyelectrolytes designed as durable anion-exchange membranes (AEMs) via ring-opening metathesis polymerization (ROMP) of cobaltocenium-containing cyclooctene with triazole as the only linker group, followed by backbone hydrogenation to provide a new class of AEMs with a polyethylene-like framework and alkaline-stable cobaltocenium cation for ion transport, which exhibit excellent thermal, chemical and mechanical stability, as well as high ion conductivity.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
B01J 45/00 - Ion-exchange in which a complex or a chelate is formedUse of material as complex or chelate forming ion-exchangersTreatment of material for improving the complex or chelate forming ion-exchange properties
H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking
H01M 8/1048 - Ion-conducting additives, e.g. ion-conducting particles, heteropolyacids, metal phosphate or polybenzimidazole with phosphoric acid
H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness
B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
The Board of Trustees of The University of Alabama (USA)
University of South Carolina (USA)
Inventor
Papish, Elizabeth
Vannucci, Aaron
Abstract
Disclosed are methods of selective hydrodeoxygenation of aromatic compounds by using catalyst systems comprising N-heterocyclic carbene (NHC) and 4-pyridinol-derived pincer ligands and metal complexes containing these ligands.
C07C 1/20 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms
B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
In general, the present disclosure is directed to methods and compositions for producing a sulfur cathode. The method includes dry mixing sulfur particles and a binder; adding a carbon source to the dry mixture; contacting the resulting dry mixture comprising the carbon source, the sulfur particles, and the binder with a solvent to form a cathode slurry; and removing the solvent from the cathode slurry to form the sulfur cathode, wherein the sulfur cathode comprises a porous shell structure covering the sulfur particles.
H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
H01G 11/24 - Electrodes characterised by structural features of the materials making up or comprised in the electrodes, e.g. form, surface area or porosityElectrodes characterised by the structural features of powders or particles used therefor
H01M 10/0569 - Liquid materials characterised by the solvents
H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes
84.
FACIAL RECOGNITION BASED ON CONVERTED SPIKING NEURAL NETWORK
The disclosure deals with a system and method recognizing the same person from different pictures in order to identify who is who based on photos or videos from different sources. Facial recognition plays an increasingly important role in modern life. Due to the low power consumption of Spiking Neural Networks (SNNs), this disclosure proposed an SNNs-based facial recognition model converted from a well-known facial recognition network ArcFace. The experimental results show that SNN (duration=200) achieved 99.00% overall accuracy on the testing dataset and outperformed the original ArcFace.
Fault diagnosis and prognosis (FDP) is critical for ensuring system reliability and reducing operation and maintenance (O&M) costs. Lebesgue sampling based FDP (LS-FDP) is an event-based approach with the advantages of cost-efficiency, uncertainty management, and less computation. In previous works, LS-FDP approaches are mainly model-based. However, fault dynamic modeling is difficult and time consuming for some complex systems and this severely hinders the applications of LS-FDP. To address this problem, this present disclosure presents a data-driven based LS-FDP framework in which deep belief networks (DBN) and particle filter (PF) are integrated to achieve fault state estimation and remaining useful life (RUL) prediction. In the proposed approach, DBN learns the state evolution model and the Lebesgue time transition model, which are used as diagnostic and prognostic models in PF for FDP. The proposed approach has higher efficiency in terms of computation and better performance in terms of FDP accuracy and precision.
G01R 31/392 - Determining battery ageing or deterioration, e.g. state of health
G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables
G01R 31/36 - Arrangements for testing, measuring or monitoring the electrical condition of accumulators or electric batteries, e.g. capacity or state of charge [SoC]
86.
MULTI-CELL NON-COHERENT OVER-THE-AIR COMPUTATION FOR FEDERATED EDGE LEARNING
A system and method are disclosed for a framework where over-the-air computation (OAC) occurs in both uplink (UL) and downlink (DL), sequentially, in a multi-cell environment to address the latency and the scalability issues of federated edge learning (FEEL). To eliminate the channel state information (CSI) at the edge devices (EDs) and edge servers (ESs) and relax the time-synchronization requirement for the OAC, we use a non-coherent computation scheme, i.e., orthogonal signaling based majority vote (MV). Multiple ESs function as the aggregation nodes in the UL. Each ES determines the MVs independently. After the ESs broadcast the detected MVs, the EDs determine the sign of the gradient through another OAC in the DL. Hence, inter-cell interference is exploited for the OAC. Convergence of the non-convex optimization problem for the FEEL is proven with the proposed OAC framework. Efficacy of the proposed method is numerically evaluated by comparing the test accuracy in both multi-cell and single-cell scenarios for both homogeneous and heterogeneous data distributions.
Methods for culturing cells, compositions comprising the cell culture product, and applications for the compositions are described. Methods include culturing cells with a media that includes a catalyst compound, which can include a stilbene or a nicotinamide compound, so as to control the secretome of the cells. Compositions that include the cell culture product include the cell secretome or components thereof in conjunction with at least one catalyst compound. Products can be utilized as a cell culture media or can be utilized in therapeutic applications.
Described herein are devices and methods for performing automated and minimally invasive intramyocardial injections for cardiac repair that eliminate the need for opening the chest cavity for injections of therapeutics to the heart muscle to address heart attack, cardiomyopathy or myocardial diseases and can detect diseased tissue and deliver a specified volume of a therapeutic injectate to the region of interest.
The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.
Deep learning-based diagnosis methods currently face some challenges and open problems. First, domain knowledge of fault modes and operating conditions are not integrated in most existing approaches, which results in low diagnosis accuracy and training efficiency. Second, existing methods treat all features with indiscriminate attention, which causes unnecessary computation and even false diagnosis results in some cases. Third, multi-task diagnosis becomes more important for health maintenance. To address these challenges, a deep residual convolutional neural network is provided with an enhanced discriminate feature learning capability and information fusion for multi-task bearing fault diagnosis. Domain knowledge is integrated with monitoring data to build the information map. Two attention modules are introduced to enhance the discriminate feature learning ability, and two classifiers are employed for multi-task diagnosis, providing significant improvements in diagnostic accuracy and training efficiency.
Presently disclosed subject matter relates to application of dielectric barrier discharge in misty plasma systems for disinfection of surfaces and equipment in health settings. A system and corresponding and/or associated methodology is provided for planar dielectric barrier discharge (DBD) device technology. Per one exemplary embodiment, a DBD device is provided with an electrically insulated annular flow channel built through the planar powered electrode. The discharge medium is air saturated with water vapor that flows through the annulus and forms a stagnation discharge plane between the powered dielectric and the substrate. Application on Escherichia (E.) coli and Bacillus (B.) atrophaeus spores on agar and filter papers show that usage of a flowing humid discharge medium has a ˜40% higher efficacy than either a static or a dry flowing medium. The substrate turns acidic potentially due to the formation of reactive oxygen and nitrogen species. In the presence of water vapor, pH can be decreased further due to formation of hydrogen peroxide from recombination of OH radicals formed in the plasma.
The present disclosure is directed to a method for treating an autoimmune disease, the method comprising administering to a subject in need thereof a cannabinoid compound comprising delta-8-tetrahydrocannabinol.
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
Electrodes for use in electrochemical cells are described. The electrodes incorporate ionomers in multiple different particulate forms, including at least one larger particle form and at least one smaller particle form. The electrodes include electrode active particles, and optionally, can also include additional binder particles or other additives. The electrodes can be used in fuel cells or electrolyzers, including hydrogen fuel cells and water electrolyzers.
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 11/095 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one of the compounds being organic
94.
DIELECTRIC BARRIER DISCHARGE PLASMA SYSTEM AND METHOD FOR IN-SITU HYDROGEN PEROXIDE PRODUCTION
The disclosure deals with system/apparatus and corresponding and/or associated method for an open plasma reactor assembly provided to study pulsed reactive species produced in a dielectric barrier discharge (DBD) in He—H2O and He—H2O—O2 mixture in atmospheric conditions using photo fragmentation laser-induced fluorescence (PFLIF). The objective is to detect and quantify hydroxyl radicals and hydrogen peroxide produced in the DBD. An OH laser-induced fluorescence (LIF) signal is acquired from LIF (using 282 nm laser) whereas LIF from OH generated from H2O2 is measured by from the PFLIF signal (using 213 nm+ 282 nm lasers). A known concentration of H2O2 in He serves to calibrate for H2O2 while the OH is calibrated with a chemical model. For both gas mixtures, there is both OH and H2O2 production in the discharge, while the H2O2 concentration was noticeably increased for the added O2 case.
Disclosed here are methods for treating a cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
Disclosed here are methods for treating a cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
Disclosed here are methods for treating a cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt or stereoisomer thereof,
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
Methods and systems for detection of precancerous colorectal cancerous lesions and early stage colorectal cancer are described. The methods and systems include examination of a rectal cell sample for the presence of mast cells in a field effect detection regime. The methods can incorporate swab-based cell collection, optionally storage and transportation of a cell sample, and/or computer-aided diagnosis.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Disclosed is a method of purifying recombinant adeno-associated virus (rAAV) particles. For instance, the rAAV particles may be derived from an AAV-producing cell culture. According to the present disclosure, the method can include a) producing a crude cell lysate comprising rAAV particles by hypotonic lysing of the cell culture; b) clarifying the crude cell lysate using filtration producing a supernatant comprising rAAV particles; c) isolating the supernatant to obtain a virus pellet comprising rAAV particles; and d) resuspending the virus pellet with a buffer to obtain purified rAAV particles.
Described herein are proton exchange membrane style electrolyzers, and methods of making same, with a polybenzimidazole (PBI) or sulfonated polybenzimidazole (s-PBI) membrane and metal catalysts on the anode and cathode, which enables both acid independent membrane resistance and lower membrane resistance with higher operating temperatures.
Described herein are systems and methods for employing a tumor targeted cerium oxide nanoparticle system, T-CeNP, for cancer therapy to hinder cancer associated fibroblast (CAF) transdifferentiation and reprogram CAFs back to normal fibroblasts to reduce tumor size and prevent metastasis.
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
Described herein are systems, methods and devices for gathering sound emission data from railway spikes in order to determine if a spike is undamaged, damaged, or broken via initiating sound waves in the spike and analyzing same to determine the structural integrity of the spike being tested.
