Abstract

An example includes a method for characterizing tissues of a patient. Hie method includes illuminating a first tissue with a light, capturing an image of the light after the light interacts with the first tissue, and generating, using the image, a. three-dimensional model that defines a surface of the first tissue. Hie method also includes performing optical coherence tomography angiography (OCTA), thereby generating a first output that indicates first positions of blood vessels beneath the surface of the first tissue. The first positions are defined with respect to the three-dimensional model. The method also includes performing polarization-sensitive optical coherence tomography (PSOCT), thereby generating a second output that indicates second positions of birefringent portions of a second tissue beneath the surface of the first tissue. Hie second positions are defined with respect to the three-dimensional model.

IPC Classes  ?

• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01N 21/23 - Bi-refringence
• G01N 21/47 - Scattering, i.e. diffuse reflection
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
• G06T 7/00 - Image analysis

Abstract

Zwitterionic phosphatidylserine (ZPS) monomers, ZPS polymers and ZPS copolymers, methods for making the ZPS monomers, ZPS polymers, and ZPS copolymers, compositions and materials that include ZPS polymers and ZPS copolymers, and methods for using the ZPS monomers, ZPS polymers, and ZPS copolymers.

IPC Classes  ?

• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 38/44 - Oxidoreductases (1)
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C07F 9/09 - Esters of phosphoric acids
• C08F 299/00 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers

Abstract

An N-path filter including a plurality of capacitors, wherein each capacitor of the plurality of capacitors is connected to a switch of a plurality of switches, a plurality of gates, wherein each switch of the plurality of switches is coupled to a gate of the plurality of gates, and wherein a CLK signal is applied to each gate of the plurality of gates, and a negative feedback circuit configured for sensing a drain source voltage (VDS) variation of each switch of the plurality of switches, and adjusting a gate source voltage (VGS) based on the VDS.

IPC Classes  ?

• H03F 1/32 - Modifications of amplifiers to reduce non-linear distortion
• H03F 3/18 - Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements with semiconductor devices of complementary types
• H03F 3/189 - High-frequency amplifiers, e.g. radio frequency amplifiers
• H03F 3/19 - High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only
• H03H 19/00 - Networks using time-varying elements, e.g. N-path filters
• H03H 7/38 - Impedance-matching networks
• H03H 7/40 - Automatic matching of load impedance to source impedance
• H03J 3/32 - Arrangements for ensuring tracking with variable capacitors
• H03F 1/08 - Modifications of amplifiers to reduce detrimental influences of internal impedances of amplifying elements
• H03F 1/26 - Modifications of amplifiers to reduce influence of noise generated by amplifying elements
• H03F 3/304 -
• H03F 3/45 - Differential amplifiers
• H03J 3/20 - Continuous tuning of single resonant circuit by varying inductance only or capacitance only

Abstract

Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of treating a subject having, or at risk of developing, muscular dystrophy, sarcopenia, heart disease, or cachexia are also provided. The methods may include administering a pharmaceutical composition including the micro-dystrophin gene and a delivery vehicle to a subject. Further, the methods may include administering the pharmaceutical composition a subject having Duchenne muscular dystrophy or Becker muscular dystrophy.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/86 - Viral vectors

Abstract

Cell-stored barcoded viral protein deep mutational scanning libraries are described. The libraries can be used to map resistance mutations to therapeutic treatments. The libraries can be used to predict viruses that become resistant to therapeutic compounds and/or may more easily evolve to infect new species. The libraries can also be used to more safely study dangerous viruses that normally require high safety biocontainment facilities. The libraries include features that allow efficient collection and assessment of informative data, obviating many bottlenecks of previous approaches.

IPC Classes  ?

• C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Abstract

An optical transmitter and receiver system splits laser inputs into multiple channels for transmission and reception. The optical transmitter receives a laser input from a forward laser path of a laser source, splits the input into a plurality of transmit channels, and transmits the channels to a destination. The optical receiver receives another laser input from the same forward laser path, splits the input into a plurality of receive channels, and processes the channels to receive data. The optical transmitter and receiver can be used in a variety of applications, including telecommunications, data centers, and industrial control systems.

IPC Classes  ?

• G02B 6/00 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings
• H04B 10/00 - Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
• H04B 10/50 - Transmitters
• H04J 14/02 - Wavelength-division multiplex systems
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

A method of performing all-to-all collective communication scheduling includes scaling a max concurrent multi-commodity flow (MCF) framework by decomposing a MCF problem and parallelizing the MCF problem to perform a fast link-based all-to-all schedule computation. The method further includes computing a time-stepped version of the MCF problem for a host-based forwarding network topology, utilizing the time-stepped version of the MCF problem to create a direct-connect graph, and then using the direct-connect graph to compute time-stepped MCF schedules to manage a mixed topology. The method further includes identifying a direct-connect topology to perform all-to-all collective communication based on the time-stepped MCF schedules.

IPC Classes  ?

• H04L 45/03 - Topology update or discovery by updating link state protocols
• H04L 45/128 - Shortest path evaluation for finding disjoint paths
• H04L 45/655 - Interaction between route computation entities and forwarding entities, e.g. for route determination or for flow table update

Abstract

A method includes everting a tubular membrane comprising a thermoplastic material such that (i) a closed end of the tubular membrane, (ii) a first distal end of a central air line, and (iii) a second distal end of a side air line move into a pharynx of a patient. The first distal end extends distally through the closed end and a first proximal end of the central air line extends proximally through an open end of the tubular membrane and a mouth of the patient. The side air line is disposed on an exterior surface of the tubular membrane, the second distal end is proximal to the first distal end and to the closed end, and a second proximal end of the side air line extends proximally through the mouth. The method also includes inflating a distal sealing cuff against an esophagus, a larynx or a trachea of the patient.

IPC Classes  ?

• A61M 16/04 - Tracheal tubes
• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

This disclosure relates to a water treatment composition and the method of making the composition. The composition is a ferrate(VI)-coated sand. The ferrate-coated sand is made by mixing the sand with tetraethyl orthosilicate followed by adding the sand to a solution of potassium ferrate.

IPC Classes  ?

• C02F 11/12 - Treatment of sludgeDevices therefor by de-watering, drying or thickening
• C02F 1/64 - Heavy metal compounds of iron or manganese
• C02F 9/00 - Multistage treatment of water, waste water or sewage

Abstract

Biomaterials and polypeptide-based biological circuits configured for conditional release of a cargo therefrom. Logical biological circuit elements, including YES, AND, and OR elements, can be used to construct biosensors and implantable devices that are configured to conditionally release a biologically relevant cargo therefrom, such as a drug, biotherapeutic, or biomarker, in an appropriate scenario.

IPC Classes  ?

• G06N 3/00 - Computing arrangements based on biological models
• C12N 9/50 - Proteinases
• C12N 9/52 - Proteinases derived from bacteria
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61L 31/14 - Materials characterised by their function or physical properties

Abstract

Systems and methods for spectrally-encoded non-scanning imaging through fiber are described. In one embodiment, a method for acquiring an endoscopic image includes: generating incoming light by a source of light; and directing the incoming light toward a metasurface filter array. The metasurface filter array includes a plurality of pixels, wherein each pixel includes a plurality of meta-atoms of a characteristic size. Characteristic sizes of the pluralities of meta-atoms differ from one pixel to another. The characteristic size of the meta-atoms of a given pixel is configured for a wavelength-specific band-pass transmission of light through the given pixel of the metasurface filter array. The method also includes transmitting spatio-spectrally encoded light through an optical fiber; decoding light transmitted through the optical fiber by a spectral decoder; and reconstructing the endoscopic image based on decoded light.

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/44 - Raman spectrometryScattering spectrometry
• H04N 23/12 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths with one sensor only
• H04N 23/50 - Constructional details

Abstract

Use of the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), mavelertinib, as a treatment for giardiasis in humans, veterinary animals, and livestock is described. Mavelertinib demonstrates a high selectivity index for Giardia compared to mammalian cells and therefore provides an effective and safe treatment for giardiasis. Therapeutically effective amounts for oral administration are also described.

IPC Classes  ?

• A61K 31/52 - Purines, e.g. adenine
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

A method and a handling system for imparting a desired longitudinal conformation into a longitudinal component are presented. The handling system comprises a rigid frame and a plurality of handling headers movably connected to the rigid frame. The plurality of handling headers is configured to grip a longitudinal component, lift the longitudinal component, and cooperatively move to impart the desired longitudinal conformation into the longitudinal component.

IPC Classes  ?

• B64F 5/50 - Handling or transporting aircraft components
• B29C 31/00 - Handling, e.g. feeding of the material to be shaped
• B29L 31/30 - Vehicles, e.g. ships or aircraft, or body parts thereof
• B64C 3/18 - SparsRibsStringers

Abstract

2222222 to co-solvent ratio is between about 10,000:1 to 1:1, and wherein a co-solvent to ion source ratio is between about 10:1 and about 1,000,000:1.

IPC Classes  ?

• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• C02F 1/26 - Treatment of water, waste water, or sewage by extraction
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

A nanocomposite proximity-pressure sensor (NPPS), configured to measure one or more human biometrics, the NPPS including a carbon nanotube-paper (CPC) electrode, a multiwalled carbon nanotubes (MWCNTs) foam, and an auxetic MWCNTs-embedded frame, wherein the auxetic MWCNTs-embedded frame is positioned around the MWCNTs foam, wherein when the auxetic frame is compressed, it expands and exerts a pressure onto the MWCNTs foam.

IPC Classes  ?

• B29C 44/34 - Component parts, details or accessoriesAuxiliary operations
• B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G01L 1/18 - Measuring force or stress, in general using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material
• H10N 30/857 - Macromolecular compositions

Abstract

The disclosure features compositions and methods for the treatment of trinucleotide repeat expansion disorders. The compositions described herein that may be used to treat such disorders include at least one nucleic acid construct comprising a first nucleic acid sequence. In some embodiments, the first nucleic acid sequence encodes a therapeutic protein. In some embodiments, the first nucleic acid sequence encodes a MBNL protein. In some embodiments, the first nucleic acid sequence encodes MBNL1 protein. The composition may comprise at least one nucleic acid construct comprising a second nucleic acid. In some embodiments, the second nucleic acid sequence encodes an interfering RNA construct that suppresses the expression of RNA transcripts containing aberrantly expanded repeat regions. Disclosed herein are also methods of increasing the presence of functional muscleblind-like protein (MBNL) in the nucleus of a cell with expression control in tissue types and methods of treating muscular dystrophy or spliceopathy using the compositions disclosed herein.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors

Abstract

Methods and systems for bonding of structures using high intensity focused ultrasound are disclosed. In one embodiment, a method for assembling components using ultrasound includes: positioning a first part of an assembly with respect to a second part of the assembly; heating a region of the assembly by focusing the ultrasound from an ultrasound transducer to the region of the assembly; and, in response to heating the region of the assembly, bonding the first part of the assembly to the second part of the assembly.

IPC Classes  ?

• B23K 1/06 - Soldering, e.g. brazing, or unsoldering making use of vibrations, e.g. supersonic vibrations
• B23K 103/00 - Materials to be soldered, welded or cut

Abstract

Systems and methods for an endoscopic vacuum therapy system are herein provided. In one example, an endoscopic vacuum therapy system a negative pressure source; a tube comprising a plurality of openings at a distal end, the tube being fluidly coupled to the negative pressure source at a proximal end; and a fluid collection element coupled to the tube, wherein the fluid collection element is compressed via a segmented dissolvable casing.

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems

Abstract

A system can include a processing device and a memory having instructions that are executable by the processing device for causing the processing device to perform operations. The operations may involve receiving or determine one or more operational constraints corresponding to an aircraft having multiple degrees of freedom. The operations may involve performing an optimization method to obtain a set of trajectory data for the aircraft subject to the one or more operational constraints, the set of trajectory data including a set of temporal state parameters that describe a state of the aircraft and a set of control input signals that are usable to control the aircraft. The operations may involve transmitting the set of trajectory data to a flight computer, the flight computer being configured to control the aircraft based on the set of trajectory data.

IPC Classes  ?

• G05D 1/654 - Landing
• G05D 1/644 - Optimisation of travel parameters, e.g. of energy consumption, journey time or distance
• G05D 109/20 - Aircraft, e.g. drones

Abstract

An example method involves providing data from an external sensor device to an electrocardiogram (ECG) application, and then decoding the ECG application's output to obtain the original sensor data. Systems described herein include external sensor devices which may provide sensor data to electronic devices, such as smartwatches, through an ECG interface.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/256 - Wearable electrodes, e.g. having straps or bands
• A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
• A61B 5/332 - Portable devices specially adapted therefor
• A61B 5/333 - Recording apparatus specially adapted therefor

Abstract

A method includes capturing one or more first images of retinal cells of an eye and illuminating the retinal cells with a first light after capturing the one or more first images, to cause the retinal cells to exhibit a first response. The method also includes capturing one or more second images of the retinal cells after illuminating the retinal cells with the first light and illuminating the retinal cells with a second light after capturing the one or more second images, to cause the retinal cells to exhibit a second response. The method also includes capturing one or more third images of the retinal cells after illuminating the retinal cells with the second light. The method also includes generating an output, using the first images, the second images, and the third images. The output quantifies the first response and the second response.

IPC Classes  ?

• A61B 3/14 - Arrangements specially adapted for eye photography
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

Compositions are disclosed comprising: (a) a wound dressing; (b) at least one polyanionic polymer layer and at least one polycationic polymer layer disposed on a surface of the wound dressing, wherein a polyanionic polymer layer alternates with a polycationic polymer layer; and (c) a-sheet polypeptides disposed within the at least one polyanionic polymer layer and/or the at least one polycationic polymer layer; methods for their use, and methods for making the compositions.

IPC Classes  ?

• A61L 15/44 - Medicaments
• A61P 31/04 - Antibacterial agents
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C08L 5/04 - Alginic acidDerivatives thereof
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
• A61K 9/70 - Web, sheet or filament bases

Abstract

Methods for testing the effects of therapeutic compound candidates on a phenotypic organoid model is provided. Such a method includes steps of generating the phenotypic organoid model on a high throughput screening platform, treating the organoid with a therapeutic compound candidate, and testing one or more effects resulting from treatment with each of the therapeutic compound candidates. The testing method that has led to identification of a method for treating or preventing cysts is provided. That method may include contacting a population of cells with an inotrope, wherein the inotrope prevents cyst formation, shrinks existing cysts, or both. That method may be used to treat cystogenic diseases or conditions such as Polycystic Kidney Disease (PKD).

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.

IPC Classes  ?

• G02B 21/33 - Immersion oils
• G02B 21/00 - Microscopes
• G02B 21/24 - Base structure
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

Disclosed and claimed is a medical delivery device with a separable housing comprising a durable component and a disposable component. The durable component comprises a handle portion of the device that may be connected to a compressed gas source to allow for the input of pressurized gas into the device. The disposable component comprises a cartridge containing a plurality of doses of biological or non-biological material and a supersonic barrel through which the dose is propelled out of the device and into the subject. When all of the doses in the cartridge have been administered, or when the device is to be used with a different subject, the cartridge is removed, and a new cartridge attached to the durable component.

IPC Classes  ?

• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
• A61M 39/22 - Valves or arrangement of valves

Abstract

Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 6/03 - Computed tomography [CT]
• A61B 6/04 - Positioning of patientsTiltable beds or the like
• A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis

Abstract

A movable carriage configured to wrap a material sheet around a longitudinal component is presented. The movable carriage comprises a frame defining a center plane and an operating volume; side wheels within the operating volume configured to guide the material sheet against sides of a portion of the longitudinal component, when disposed within the operating volume and aligned with the center plane, as the movable carriage moves parallel to the center plane, the side wheels arranged as one or more opposing pairs about the center plane; and top wheels within the operating volume configured to guide the material sheet against the top of the portion of the longitudinal component as the movable carriage moves parallel to the center plane, the top wheels arranged as one or more opposing pairs about the center plane.

IPC Classes  ?

• B29C 63/04 - Lining or sheathing, i.e. applying preformed layers or sheathings of plasticsApparatus therefor using sheet or web-like material by folding, winding, bending or the like
• B29C 63/00 - Lining or sheathing, i.e. applying preformed layers or sheathings of plasticsApparatus therefor
• B29L 31/00 - Other particular articles

Abstract

de novode novo designed human IL-17 (hIL-17) binding polypeptides, compositions thereof, and methods for their use in treating subjects. The provided compositions can modulate the interaction of hIL-17 with the hIL-17 receptor, and can be used in the management of inflammatory disorders including psoriasis, psoriatic arthritis, ankylosing spondylitis, active non-radiographic axial spondyloarthritis, multiple sclerosis, asthma, and rheumatoid arthritis.

IPC Classes  ?

• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

A noninvasive blood-based biopsy measures surface protein receptors on specific circulating cell populations. Dysregulated quantities of specific surface protein receptors on specific circulating cells indicate the diseased tissue origin. Thus, specific circulating cells serve as proxies for diseased tissue cells as they are shed from such tissues. This approach can be used not only for preeclampsia but also for other vascular disorders where detecting surface protein receptors associated with particular disorders can increase sensitivity and disease specificity. Detection of a high level VEGFR1 on isolated circulating cells that are immunopositive for CD34 and CD31 can be used to identify and treat subjects suffering from preeclampsia.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

Polypeptides are provide having an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:1-17, wherein the polypeptide binds to a chlorophyll (Chl) dimer, and scaffolds thereof.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

The present disclosure provides peptides, chimeric molecular constructs, and compositions thereof, that can bind volatile organic compounds (VOCs) and be utilized to distinguish VOC profiles, e.g., indicative of disease, as well as related methods. A VOC-based gas sensing approach described in the present specification can be an effective screening tool, due, at least in part, to its speed, ease of use, sensitivity, specificity, and because it does not rely on binding to specific nucleic acid fragments or proteins to function.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Fusion proteins are provided that include (a) a stabilizer peptide including domains X1-X2, wherein (i) XI includes the amino acid sequence of SEQ ID NO: 1; and (ii) X2 is a first amino acid linker of between 5-20 amino acids in length; and (b) a truncated class I major histocompatibility complex (MHC) protein directly fused to the C-terminus of the stabilizer peptide, wherein the truncated MHC protein consists of residues 1-175, 1-176, 1- 177, 1-178, 1-179, 1-180, 1-181, 1-182, 1-183, 1-184, or 1-185 of a class I MHC protein, optionally wherein the truncated class I MHC protein comprises residues 6K, 81, 121, 104D, 105E, 106N, and 110V, and optionally wherein the truncated class I MHC protein comprises residue 84A.

IPC Classes  ?

• C07K 14/74 - Major histocompatibility complex [MHC]
• A61K 40/32 - T-cell receptors [TCR]
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present disclosure provides an orthopedic brace including: a leg cuff; a footplate; and a strut coupling the leg cuff to the footplate. The strut includes a first member with opposite first and second ends, a second member coupled at a first end to the first end of the first member, and a third member coupled at a first end to the second end of the first member. The brace further includes a first adjustable coupling element connecting the second member to the first member, and a second adjustable coupling element connecting the third member to the first member. The stiffness and/or bending location of the strut is adjustable based on the position of at least one of the adjustable coupling elements along the length of the first member.

IPC Classes  ?

• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

A manufacturing system and method for determining and optimizing shaping locations and shaping inputs and shaping a component using the shaping locations and shaping inputs includes steps of: determining shaping locations on the component for application of shaping inputs that change an as-built shape of the component toward a target shape of the component and determining the shaping inputs to be applied to the component at the shaping locations to change the as-built shape of the component toward the target shape of the component; applying the shaping inputs to the component at the shaping locations on the component; and changing the as-built shape of the component to within a predetermined tolerance of the target shape.

IPC Classes  ?

• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
• G06F 119/18 - Manufacturability analysis or optimisation for manufacturability

Abstract

A rolling metamaterial cell for a helmet is disclosed herein. The cell can include an upper semi-spherical portion configured to be operably coupled to an outer shell of the helmet; a lower semi-spherical portion configured to be operably coupled to an inner layer of the helmet; a first deformable structure adjacent to the upper semi-spherical portion; and a second deformable structure adjacent to the rounded lower portion. The first and second deformable structures are configured to compress upon impact force applied to the outer shell of the helmet, wherein the compression rotates a central ring between the deformable structures relative to the upper and lower semi-spherical portions. A helmet can include an outer shell, an inner shell arranged inward from the outer shell, and a plurality of the rolling metamaterial cells arranged therebetween.

IPC Classes  ?

• A42B 3/06 - Impact-absorbing shells, e.g. of crash helmets
• A42B 3/04 - Parts, details or accessories of helmets
• A42B 3/10 - Linings
• A42B 3/12 - Cushioning devices

Abstract

Methods and systems to reduce symptoms of cerebral palsy in children are disclosed herein. In one embodiment, a method for alleviating spasticity of a lower extremity caused by a brain injury includes attaching at least one electrode on a surface of patient's skin, proximate to patient's spinal cord. The method also includes subjecting the patient to a regimen of training that improves walking of the patient; applying a series of pulses to the at least one electrode while the patient is in training; and in response to applying the series of pulses to the at least one electrode, inducing stimulation in the spinal cord that alleviates spasticity of the lower extremity.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A63B 22/02 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with movable endless bands

Abstract

Microfluidic systems, kits, and methods for characterization of polycystic kidney disease (PKD) are described. In an embodiment, the microfluidic system includes a flow device comprising an inlet, an outlet, and a channel comprising a functionalized site configured for cell culture. In an embodiment, a genetically modified (GM) human kidney organoid is cultured at the functionalized site, optionally in the presence of a fluidic flow, to produce PKD cysts for use as a model system for characterization of mechanisms of PKD onset, progression, diagnosis, and response to treatment.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

The invention described here contains a nucleic acid expression cassette comprising a transcriptional regulatory region operably linked to a nucleic acid sequence encoding a FKRP, an RNA transcript comprising a modified 5′ and/or 3′ untranslated region (UTR) that will be utilized to treat a variety of FKRP-mediated diseases.

IPC Classes  ?

• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61K 38/45 - Transferases (2)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/86 - Viral vectors

Abstract

Synthetic genetic platforms in eukaryote cells (such as yeast) is described. A representative synthetic genetic platform includes a eukaryote cell genetically modified to express an auxin receptor, an auxin response factor, and a reporter, as well as a fusion construct including a Lis1 Homology (LisH) domain fused to an auxin-responsive protein. The synthetic genetic platforms can be used, for instance, to understand developmental and pathological LisH domain variants, and to test bioactive molecules for LisH domain activity.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

Abstract

The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

IPC Classes  ?

• C12N 9/88 - Lyases (4.)
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/14 - Particulate form, e.g. powders
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

A diagnostic system for analyzing an analyte is described. In an embodiment the diagnostic system includes a fluidic single-use disposable and a base cooperatively coupleable thereto. In an embodiment, the fluidic single-use disposable comprises a sample processing subcomponent configured to receive a sample and emit signal light if the sample comprises an analyte; a fluidic single-use disposable housing encompassing the sample processing subcomponent, the fluidic single-use disposable housing comprising: a first major side; and a fluidic single-use disposable viewing window disposed in the first major side and positioned to allow light emitted from the sample processing subcomponent to pass through the fluidic single-use disposable viewing window. In an embodiment, the base comprises a base housing comprising: a first major side shaped to cooperatively couple with the first major side of the fluidic single-use disposable housing.

IPC Classes  ?

• G01N 21/03 - Cuvette constructions
• B01L 1/00 - EnclosuresChambers
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Chromophores with large hyperpolarizabilities, films with electro-optic activity comprising the chromophores, and electro-optic devices comprising the chromophores are disclosed.

IPC Classes  ?

• C07D 495/04 - Ortho-condensed systems
• C07D 307/28 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07F 7/08 - Compounds having one or more C—Si linkages
• G02F 1/361 - Organic materials
• H10K 85/40 - Organosilicon compounds, e.g. TIPS pentacene
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Inserts for a specimen collection tube and kits for collecting and metering biofluids are described. In an example, the insert comprises a fluidic channel separator defining an aperture, wherein the aperture is configured to limit flow of a fluid therethrough by hydrostatic forces between the fluid and the aperture; and a plurality of legs extending outwardly from a side of the fluidic channel separator. In an example, the kit comprises a specimen collection tube and an insert sized and shaped to fit in the sample collection tube, such as to meter a biofluid provided to the specimen collection tube. In an example, the insert comprises a flange extending from a disc of the fluidic channel separator.

IPC Classes  ?

• G01N 1/18 - Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• B01D 33/00 - Filters with filtering elements which move during the filtering operation

Abstract

A trivalent vaccine induces robust antibody and mucosal and systemic IFN-γ and Th17 T cell responses against Coccidioides and affords complete protection from fungal dissemination and disease. The combination of the three antigens of this trivalent vaccine can exert synergistic protection against lethality, disease and fungal dissemination. These robust responses can be further enhanced by use of one or more additional antigens described herein.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• C07K 14/37 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from fungi
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• A61P 31/10 - Antimycotics
• A61P 37/04 - Immunostimulants
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

In an embodiment, the present disclosure pertains to an organ-specific wireless optogenetic device. In some embodiments, the device includes an electronic circuit, such that the electronic circuit is configured to harvest and convert radio frequency (RF) energy into optical energy and a tether having a μLED, where the μLED illuminates targeted regions in the organ. In an additional embodiment, the present disclosure pertains to a method of treating obesity. In general, the method includes implanting an organ-specific wireless optogenetic device into a subject, activating an RF-power system to produce RF energy, harvesting, by the organ-specific wireless optogenetic device, the RF energy, converting, by the organ-specific wireless optogenetic device, the RF energy into optical energy, illuminating, by the μLED, targeted regions in the stomach of the subject, and stimulating nerve endings to thereby suppress appetite in the subject.

IPC Classes  ?

• A61F 5/00 - Orthopaedic methods or devices for non-surgical treatment of bones or jointsNursing devices

Abstract

A computer-implemented method of phenotype classification is provided. A computing system receives a plurality of segmented events generated by a plurality of nanopores in response to a sample being applied to the plurality of nanopores, wherein each segmented event of the plurality of segmented events represents ionic current changes during a protein interaction with a nanopore of the plurality of nanopores. The computing system processes the plurality of segmented events to create at least one set of model input data. The computing system provides the at least one set of model input data as input to at least one classifier model to generate a classification of the sample. The computing system transmits the classification for presentation on a display device.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR

Abstract

Compressed meta-optical encoder for image classification, and associated systems and methods are presented. In one embodiment, a convolutional neural network (CNN) system for image classification includes a meta-optics having a plurality of convolutional kernels. Each convolutional kernel includes a plurality of nanostructures. The plurality of kernels are configured for convolving source images by applying their respective point spread functions (PSFs) to the source images. The system also includes an image capturing camera configured for capturing convolved images, and an electronic backend software configured for classifying the source images based on the convolved images.

IPC Classes  ?

• G02B 1/02 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of crystals, e.g. rock-salt, semiconductors
• G02F 1/35 - Non-linear optics
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• H04N 23/957 - Light-field or plenoptic cameras or camera modules
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals

Abstract

This disclosure describes examples of systems, apparatuses, and methods for performing wireless communication using thermal noise of one or more components of the systems. An example method includes modulating thermal noise in a transmitter based on data to provide a signal and transmitting the signal including the data as output of the transmitter.

IPC Classes  ?

• H04B 1/04 - Circuits

Abstract

A fracture reduction tool for performing bone fracture reduction is disclosed herein. In one example, the fracture reduction tool includes a first baseplate, a second baseplate, and a flexible linker coupled between the first baseplate and the second baseplate, wherein the flexible linker comprises a gooseneck component configured to move and bend in multiple degrees of freedom.

IPC Classes  ?

• A61F 5/05 - Devices for stretching or reducing fractured limbsDevices for distractionsSplints for immobilising
• A61B 17/68 - Internal fixation devices
• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

Abstract

Examples described herein may image a tissue sample while tracking a surface of the tissue sample. At least one image of the tissue sample may be obtained using a 3D microscope system, the at least one image including a surface of the tissue sample. A position of the surface of the tissue sample may be detected based on the at least one image. A signal indicative of the position may be provided to control an axis of the microscope to obtain a subsequent image at a different lateral position of the tissue sample having a surface of the sample at a predetermined position within a frame of the subsequent image. Techniques and systems for positive margin identification in a tissue sample are also described.

IPC Classes  ?

• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06T 7/00 - Image analysis
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

IPC Classes  ?

• A61K 31/765 - Polymers containing oxygen
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/51 - Nanocapsules
• A61K 31/795 - Polymers containing sulfur
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

A multiple gate system for realizing the quantum anomalous Hall effect, including a top channel electrode which controls carrier density and electric field in a conduction channel, a first dielectric layer for the top channel gate, a patterned contact gate electrode which controls earner density on the contact and screens the top channel electrode's electric field on the contact, and a second dielectric layer for the contact gate, an electrically tunable material comprising semiconducting molybdenum ditelluride in the form of a first atomic sheet and a second atomic sheet, wherein first atomic sheet is rotated planarly from the second atomic sheet by about 2.5 to about 5 degrees, to form a geometrically stacked homobilayer moiré superlattice configured to host ferromagnetic states that spontaneously break time-reversal symmetry, where a perpendicular electric field is applied to the electrically tunable material, tuning the quantum anomalous Hall effect.

IPC Classes  ?

• H10N 52/80 - Constructional details
• H01F 10/12 - Thin magnetic films, e.g. of one-domain structure characterised by magnetic layers characterised by the composition being metals or alloys
• H10D 62/10 - Shapes, relative sizes or dispositions of the regions of the semiconductor bodiesShapes of the semiconductor bodies
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Candida aurisCandida aurisCandida aurisC. aurisC. aurisCandidaC. aurisC. aurisC. aurisC. auris screening, and can be adapted in high-throughput laboratory approaches.

IPC Classes  ?

• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
• C12N 1/14 - Fungi Culture media therefor
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• C12R 1/72 - Candida
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Embodiments of the present disclosure provide systems, devices, and methods for solving combinatorial optimization problems using a device that functions as a CMOS Ising machine. An example device includes circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation. The circuitry for linear operation includes a plurality of SRAM cells in an SRAM cell array that store values of a coupling matrix. In some embodiments, circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation may be fabricated on a semiconductor substrate. In some embodiments, the device may include a feedback loop including circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation, wherein the circuitry for linear operation is coupled to the circuitry for nonlinear operation.

IPC Classes  ?

• G06F 17/11 - Complex mathematical operations for solving equations
• G06F 17/16 - Matrix or vector computation

Abstract

Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6855 - Ligating adaptors

Abstract

An example method includes transmitting, by a single ultrasound transducer, an incident ultrasound signal and detecting, at least partially from an object within a ringdown range of the single ultrasound transducer and by the single ultrasound transducer, a received ultrasound signal. A ringdown artifact is removed from data indicative of the received ultrasound signal. Based on removing the ringdown artifact, the object is analyzed based on the data.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/29 - Forceps for use in minimally invasive surgery

Abstract

1,2,3-Triazole compounds that are KLHDC2 binding compounds and methods for their use for inhibiting the activity of KLHDC2.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/33 - Heterocyclic compounds

Abstract

In one aspect, a method described herein can be used for laser carrier recovery in optical coherent communication systems utilizing quadrature amplitude modulation (QAM) at a receiver. The method includes receiving, at the receiver, a transmitted signal modulated using QAM and a local oscillator (LO) signal. The method includes detecting, at the receiver, a phase offset between the transmitted signal and the LO signal. The method includes compensating, at the receiver, by generating an error signal based on the average power and/or voltage difference between the In-phase (I) and Quadrature-phase (Q) paths of the received signal at the receiver, where the error signal compensates for the phase offset between the transmitted signal and the LO signal.

IPC Classes  ?

• H04B 1/12 - Neutralising, balancing, or compensation arrangements
• H04B 17/00 - MonitoringTesting
• H04B 10/07 - Arrangements for monitoring or testing transmission systemsArrangements for fault measurement of transmission systems

Abstract

Improved methods for quickly and completely reconstructing the interior surface of the bladder, based on images/video generated via cystoscopy, are provided. These methods include the training of a Neural Radiance Field (NeRF) model based on the images/video to represent the optical properties of the entire interior space of the bladder. The trained NeRF can then be used to quickly render arbitrary images of the inside of the bladder, which can then be composited into a complete model of the geometry and texture of the entire interior of the bladder. Improvements described herein, including the use of an actuated endoscope to control the location, orientation, and velocity of the endoscope, enable faster and more accurate training of the NeRF model, leading to full reconstruction of the entire interior surface of the bladder in minutes or less.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G06T 15/04 - Texture mapping
• G06T 17/10 - Volume description, e.g. cylinders, cubes or using CSG [Constructive Solid Geometry]
• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06T 5/94 - Dynamic range modification of images or parts thereof based on local image properties, e.g. for local contrast enhancement
• G06T 7/579 - Depth or shape recovery from multiple images from motion

Abstract

The present disclosure is generally directed to macrocyclic oligoamides useful in the inhibition of HDAC6, and methods for treating diseases that are ameliorated by the inhibition of HDAC6.

IPC Classes  ?

• C07K 5/02 - Peptides having up to four amino acids in a fully defined sequenceDerivatives thereof containing at least one abnormal peptide link
• A61K 38/12 - Cyclic peptides

Abstract

Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens
• A61P 31/14 - Antivirals for RNA viruses
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

Dynamic mode decomposition technique for doppler-based imaging of cavitation bubbles in pulsed high intensity focused ultrasound is described. A method for imaging transient cavitation bubbles in a tissue of a patient using ultrasound imaging includes: generating a burst of therapy ultrasound waves by a focused therapy transducer; and generating cavitation bubbles by the burst of therapy ultrasound waves at a target region that is a focal region of the tissue. After generating a plurality of the gas bubbles at the target region and within a time period of the dissolving process, imaging ultrasound pulses are generated by an imaging probe. Generating ultrasound images as B-scan images based on returning ultrasound signals. The filtering is configured for isolating representations of dissolving gas bubbles from representations of surrounding tissue, and determining spatial and temporal attributes of the sub-mm scale gas bubbles.

IPC Classes  ?

• A61N 7/02 - Localised ultrasound hyperthermia
• G06T 7/00 - Image analysis
• A61B 8/08 - Clinical applications
• G06T 7/10 - SegmentationEdge detection
• G06T 7/20 - Analysis of motion
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present disclosure provides methods for fabricating an instrumented prosthetic socket including a. layered, fabrication with inductive sensors positioned between electrically insulating layers of the socket. The present disclosure further provides methods for tracking of position relationship between socket and socket liner using inductive sensor arrays, and inductive sensor configurations for placement on a curved surface.

IPC Classes  ?

• A61F 2/76 - Means for assembling, fitting, or testing prostheses, e.g. for measuring or balancing
• A61F 2/50 - Prostheses not implantable in the body
• A61F 2/60 - Artificial legs or feet or parts thereof
• A61F 2/70 - Operating or control means electrical
• A61F 2/78 - Means for protecting prostheses or for attaching them to the body, e.g. bandages, harnesses, straps, or stockings for the limb stump

Abstract

An example method involves receiving a plurality of data streams, including a first data stream and a second data stream, and an incident carrier signal. The first data stream is packetized into a first set of Bluetooth packets, and the second data stream into a second set of Bluetooth packets. These Bluetooth packets are then backscattered by a backscatter modulator using an incident carrier signal, with the first set of packets backscattered in a first Bluetooth channel and the second set in a second Bluetooth channel. In this manner, a backscatter device may backscatter into multiple Bluetooth channels simultaneously.

IPC Classes  ?

• H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
• H04B 7/00 - Radio transmission systems, i.e. using radiation field
• H04B 1/525 - Hybrid arrangements, i.e. arrangements for transition from single-path two-direction transmission to single-direction transmission on each of two paths or vice versa with means for reducing leakage of transmitter signal into the receiver
• H04B 5/00 - Near-field transmission systems, e.g. inductive or capacitive transmission systems
• H04L 27/00 - Modulated-carrier systems

Abstract

Disclosed herein are polypeptides that bind to the epithelial cell adhesion molecule (EpCAM) and programmed death-ligand I (PDL 1) receptors, nucleic acids encoding them, and methods for their use in treating or limited development of cancer, auto immune disease, or inflammation. The disclosure further provides nucleic acids encoding a polypeptide of the disclosure: expression vector comprising a nucleic acid of the disclosure operatively linker to a suitable regulatory control element, host cells comprising a polypeptide, fusion protein, nucleic acid, or expression vector of any embodiment of the disclosure, and pharmaceutical compositions, comprising the polypeptide, fusion protein, nucleic acid, expression vector, or host cell of any embodiment; and a pharmaceutically acceptable carrier.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Nanoporous selective sol-gel ceramic membranes, selective-membrane structures, and related methods are described. Representative ceramic selective membranes include ion-conductive membranes (e.g., proton-conducting membranes) and gas selective membranes. Representative uses for the membranes include incorporation into fuel cells and redox flow batteries (RFB) as ion-conducting membranes.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 71/02 - Inorganic material
• B01D 71/28 - Polymers of vinyl aromatic compounds
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C04B 35/10 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on aluminium oxide
• C04B 35/14 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silica
• C04B 35/48 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates
• C04B 35/624 - Sol-gel processing
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

A channel crawler has a carriage, a stabilizing mechanism, and a deployment mechanism. The carriage has wheels configured to engage surfaces that define a channel through which the carriage is configured to move. The stabilizing mechanism is configured to extend from the carriage and engage a non-horizontal surface of the channel in a manner restricting unintended movement of the carriage in one or more directions. The deployment mechanism is configured to fit within the carriage when retracted, and selectively deploy an operational device from a stowed position within the carriage to a deployed position outside the channel for performing an operation in relation to at least one of structure and hardware proximate the channel.

IPC Classes  ?

• B64F 5/60 - Testing or inspecting aircraft components or systems
• B25J 5/02 - Manipulators mounted on wheels or on carriages travelling along a guideway

Goods & Services

downloadable software application connecting patients with health care teams for supporting the increase of prescribed physical activity for health. software platform connecting patients with health care teams in support of increasing prescribed physical activity for health Sports medicine services

Goods & Services

Educational services, namely, conducting programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, and printed materials distributed therewith; Educational services, namely, conducting personal training of individuals to conduct programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, downloadable implementation toolkits distributed therewith, and distribution of training material in connection therewith

Goods & Services

Educational services, namely, conducting programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, and printed materials distributed therewith; Educational services, namely, conducting personal training of individuals to conduct programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, downloadable implementation toolkits distributed therewith, and distribution of training material in connection therewith

Abstract

In one aspect, an antenna may include a waveguide with a dielectric material disposed within the waveguide, where the dielectric material may include a dielectric constant matched or near-matched to a dielectric constant of liquid water. The antenna can selectively be configured to communicate using one or more very high frequency (VHF) or one or more ultra high frequency (UHF) radio frequencies through liquid water.

IPC Classes  ?

• H01Q 1/34 - Adaptation for use in or on ships, submarines, buoys or torpedoes
• H01Q 1/28 - Adaptation for use in or on aircraft, missiles, satellites, or balloons
• H01Q 13/00 - Waveguide horns or mouths Slot antennas Leaky-waveguide antennas Equivalent structures causing radiation along the transmission path of a guided wave
• H01Q 15/24 - Polarising devicesPolarisation filters
• H04B 13/02 - Transmission systems in which the medium consists of the earth or a large mass of water thereon, e.g. earth telegraphy

Abstract

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes opioids such as fentanyl and carfentanil. Also provided are methods of making and using these constructs.

IPC Classes  ?

• C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

This disclosure relates to methods and systems for imaging biopsy samples. The system for imaging biopsy samples comprises a window and an imaging device. The window comprises an inflexible and optically clear material. The window is configured to compress a sample disposed in a biopsy needle. The imaging device is configured to maintain a constant working distance to the flattened tissue surface while scanning. The imaging device is configured to capture one or more images of the sample through the window.

IPC Classes  ?

• G01N 1/31 - Apparatus therefor
• G01N 1/30 - StainingImpregnating
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

The methods and compositions relate to the improvement of cell viability regarding in vitro differentiated cardiomyocytes. Addition of ROCK-inhibitors to pluripotent stem cells in combination with factors modulating differentiation pathways improves in-vitro differentiated cardiomyocyte viability and fitness.

IPC Classes  ?

• A61K 35/34 - MusclesSmooth muscle cellsHeartCardiac stem cellsMyoblastsMyocytesCardiomyocytes
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6855 - Ligating adaptors
• C12Q 1/6869 - Methods for sequencing
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms

Abstract

An example system includes a plurality of microphones placed proximate a head of a user. The microphones receive acoustic signals from the environment and generate corresponding input audio signals. The example system includes a trained machine learning model. This model receives input audio signals and extracts target audio signals corresponding to sources within a specified threshold distance from the user. These target audio signals are then provided to the speaker for playback to the user. This may create a sound bubble for the user.

IPC Classes  ?

• G10L 21/0308 - Voice signal separating characterised by the type of parameter measurement, e.g. correlation techniques, zero crossing techniques or predictive techniques
• G06N 3/02 - Neural networks
• G06N 3/09 - Supervised learning
• G06N 20/00 - Machine learning
• H04R 5/027 - Spatial or constructional arrangements of microphones, e.g. in dummy heads

Abstract

Systems and methods for culture of human kidney organoids as a model system for characterizing kidney pathologies and implementing therapeutics for conditions that affect the kidney. A model system for characterization of a pathophysiology includes a culture of human kidney organoids and an organoid culture medium. The organoids may include one or more genome edits as part of an approach for studying genetic factors involved with a pathological process. The culture may include one or more other factors, such as pathological agents and/or anti-pathological agents, for development and evaluation of therapeutics. The approaches may be used for implementation of compositions and methods for virally transducing the kidney or a subset of cells or cell types thereof.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)

Abstract

Polypeptides having an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1-20 and 33-58 are provided, fusion proteins thereof, kits thereof, and methods for their use as sensing devices and for other uses.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a baffle section configured to start the projectile in the ram accelerator without an obturator. The ram accelerator generally includes a tube having a projectile bore; and a baffle section operably coupled to a proximal end of the tube. The baffle section has an annular baffle wall defining a central bore axially aligned with the projectile bore; and a propellant chamber arranged adjacent to the annular baffle wall, wherein the propellant chamber is configured to enclose a propellant. The propellant can be ignited as the projectile passes through the baffle section by pressure created by the projectile, by an ignition source, or by a flame carried by the projectile to start the ram acceleration of the projectile.

IPC Classes  ?

• F41A 1/02 - Hypervelocity missile propulsion using successive means for increasing the propulsive force, e.g. using successively initiated propellant charges arranged along the barrel lengthMultistage missile propulsion

Abstract

A tool for producing films comprising a chuck configured to move a substrate, a slot die head configured to deposit one or more liquids onto the substrate, an air knife coupled to a gas source with a supply tube, the air knife configured to blow gas onto the substrate, a gantry configured to position the air knife, one or more controllers configured to collect one or more air knife data, one or more in-situ configured to determine an optimal position of the air knife, and a processor configured to receive position data from the in-situ monitor, receive one or more air knife data from the one or more controllers, analyze the received data with one or more machine learning/artificial intelligence (ML/AI) algorithms to predict a coating condition, compare the coating condition with a desired coating condition, and adjust one or more parameters of the air knife to meet the desired coating condition.

IPC Classes  ?

• B05C 5/02 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work from an outlet device in contact, or almost in contact, with the work
• G06N 20/00 - Machine learning
• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B29C 39/14 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor for making articles of indefinite length
• B05C 5/00 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work

Abstract

Techniques for generating and utilizing adult hepatocyte organoids are described. An example method includes generating an organoid by culturing hepatocytes obtained from an adult donor in a hepatocyte culture medium. The hepatocyte culture medium includes a basal medium and 5 μM of a TGF-β inhibitor.

IPC Classes  ?

• A61K 35/407 - LiverHepatocytes
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel.

IPC Classes  ?

• G02B 21/06 - Means for illuminating specimen
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/33 - Immersion oils
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides

Abstract

Extendable and flexible drive shaft members and drive shaft assemblies include circumferentially distributed anisotropic mechanisms configured to accommodate extension and flexure. A drive shaft member includes anisotropic mechanisms that are interconnected and distributed circumferentially around a longitudinal centerline of the drive shaft member. Each of the anisotropic mechanisms is configured to accommodate extension of the anisotropic mechanism parallel to the longitudinal centerline. The anisotropic mechanisms combine to transmit a torque along the longitudinal centerline.

IPC Classes  ?

• F16C 1/04 - Articulated shafts

Abstract

High-throughput methods for screening candidate DNA sequences for functionality as genetic insulators in plant genetic environments, as well as genetic insulators identified by the methods and plants that include the genetic insulators as transgenic elements. Genetic insulators can be cloned with transgenes, and introduced to plant cells, tissues, and organisms, for tighter control of transgene expression.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Goods & Services

Downloadable software, namely in molecular modeling of protein structures Software design for the purposes of molecular modeling of protein structures.

Abstract

A system includes a container configured to contain a liquid. The system also includes a tubing apparatus having a first port configured for connection to a gas source, a second port configured for connection to a patient interface, and a third port configured for submersion within the liquid. The system also includes an actuator configured to move the third port vertically within the container. A method includes flowing gas into the first port of the tubing apparatus to the patient interface via the second port of the tubing apparatus. The method also includes moving the third port of the tubing apparatus vertically within the container such that an amount of the liquid in the container that is above the third port changes, thereby changing a pressure at the patient interface.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes

Abstract

Compositions, nucleic acid molecules and methods for inducing retinal regeneration and reprogramming of Müller glia (MG) into retinal ganglion cells in a subject are described. Developmental retinal ganglion cell (RGC) transcription factors Pou4f2 and Islet1 increase the Ascl1-induced neurogenic capacity of MG. The combination of Ascl1, Pou4f2 and Islet1 stimulates MG to generate bipolar cells and RGC-like neurons. Likewise, the transcription factor Onecut1, which is expressed in developing retinal cells, but not in MG, induces MG to generate RCG-like cells. Additional transcription factors that can be used include Irx2, Irx5, Neurod2, Ebf1, and Tcf3. MG-derived RGCs can exhibit action potentials in vivo, and display chromatin profiles similar to developing RGCs.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 15/86 - Viral vectors

Abstract

Polypeptides having an amino acid sequence at least 50% identical to, and identical at least at one identified interface position, to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-44, and polypeptides having an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NO: 45-58, are provided, as well as fusion proteins thereof, nanoparticles thereof, and methods for treating or limiting development of an infection.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

e.g.e.g., dNTPs that differ chemically or physically from canonical dNTPs), in place of canonical dNTPs, that are incorporated into copies of the target sequences in place of canonical dNTPs. Due to the presence of the analog dNTPs in the copy sequences, the copy sequences exhibit different electrical signatures compared with the target sequences and can be used for improving confidence in base-calling and reducing the complexity of the sequencing problem.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.

IPC Classes  ?

• G02C 7/02 - LensesLens systems
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• B29D 11/00 - Producing optical elements, e.g. lenses or prisms
• G02C 7/04 - Contact lenses for the eyes
• G02C 7/10 - Filters, e.g. for facilitating adaptation of the eyes to the darkSunglasses
• G02C 7/16 - Shades, shieldsObturators, e.g. with pinhole, with slot

Abstract

The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.

IPC Classes  ?

• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a first tube body having a first projectile bore, a second tube body having a second projectile bore axially aligned with the first projectile bore, and a baffle positioned between and operably coupling the first and second tube bodies. The baffle can have an annular baffle wall defining a central bore that is axially aligned with the first and second projectile bores, and a chamber arranged adjacent to the annular baffle wall. The chamber can extend radially outward from the central bore and the annular baffle wall can be configured to sweep a combustion wave relative to the projectile to prevent the combustion wave from traveling ahead of the projectile, leading to an unstart mechanism of the projectile in the ram accelerator.

IPC Classes  ?

• F41A 21/16 - Barrels or gun tubes characterised by the shape of the bore

Abstract

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

Use of 4-(Propan-2-yl)-N-(pyridin-4-yl)benzamide (C15H16N2O) and similar compounds to treat pain and reduce the aversiveness of negative stimuli is described. The treatments can alleviate pain, anxiety, and depression. Such treatment may reduce the perception of pain or experience of an aversive reaction to a stimulus. The treatments can activate particular portions of the brain region, such as a subpallium or a telencephalic region.

IPC Classes  ?

• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

IPC Classes  ?

• A61K 38/03 - Peptides having up to 20 amino acids in an undefined or only partially defined sequenceDerivatives thereof
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

Abstract

Conditionally active receptor agonists that, when activated, bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αcheterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.

IPC Classes  ?

• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• A61K 38/20 - Interleukins
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• A61P 37/04 - Immunostimulants
• C07K 14/54 - Interleukins [IL]
• C07K 14/55 - IL-2

Abstract

Nalfurafine ester derivatives, formulations that include the nalfurafine ester derivatives, and methods for using the nalfurafine ester derivatives and formulations for promoting stress-resilience.

IPC Classes  ?

• C07D 489/08 - Oxygen atom
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61P 17/04 - Antipruritics

Abstract

Techniques described herein are directed to performing error correction for enhanced aerospace safety and navigation. For example, a carrier board used in a sensor pod system for a vehicle can include a feedback bus, a control output bus, and a processing device. the feedback bus can receive inputs from interface boards. The control output bus can provide outputs to the interface boards. The processing device can control a serial communications module that can manage operation of the feedback bus and the control output bus. The processing device can also implement an error correction system that can analyze sensor parameters received over the feedback bus. The error correction system can generate analyzed output including error corrections for the sensor parameters for outputting by the control output bus. The error correction system may determine, based on the analyzed sensor parameters, error types associated with errors with the inputs from the interface boards.

IPC Classes  ?

• G01C 25/00 - Manufacturing, calibrating, cleaning, or repairing instruments or devices referred to in the other groups of this subclass
• H04N 7/035 - Circuits for the digital non-picture data signal, e.g. for slicing of the data signal, for regeneration of the data-clock signal, for error detection or correction of the data signal
• G01D 3/036 - Measuring arrangements with provision for the special purposes referred to in the subgroups of this group mitigating undesired influences, e.g. temperature, pressure on measuring arrangements themselves
• G01D 5/244 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing characteristics of pulses or pulse trainsMechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means generating pulses or pulse trains
• G01D 18/00 - Testing or calibrating apparatus or arrangements provided for in groups
• B64D 45/00 - Aircraft indicators or protectors not otherwise provided for
• G01C 23/00 - Combined instruments indicating more than one navigational value, e.g. for aircraftCombined measuring devices for measuring two or more variables of movement, e.g. distance, speed or acceleration
• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06T 7/80 - Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration