A system can include a processing device and a memory having instructions that are executable by the processing device for causing the processing device to perform operations. The operations may involve receiving or determine one or more operational constraints corresponding to an aircraft having multiple degrees of freedom. The operations may involve performing an optimization method to obtain a set of trajectory data for the aircraft subject to the one or more operational constraints, the set of trajectory data including a set of temporal state parameters that describe a state of the aircraft and a set of control input signals that are usable to control the aircraft. The operations may involve transmitting the set of trajectory data to a flight computer, the flight computer being configured to control the aircraft based on the set of trajectory data.
An example method involves providing data from an external sensor device to an electrocardiogram (ECG) application, and then decoding the ECG application's output to obtain the original sensor data. Systems described herein include external sensor devices which may provide sensor data to electronic devices, such as smartwatches, through an ECG interface.
The Board of Trustees of the Leland Stanford Junior University (USA)
Inventeur(s)
Sabesan, Ramkumar
Pandiyan, Vimal Prabhu
Palanker, Daniel
Abrégé
A method includes capturing one or more first images of retinal cells of an eye and illuminating the retinal cells with a first light after capturing the one or more first images, to cause the retinal cells to exhibit a first response. The method also includes capturing one or more second images of the retinal cells after illuminating the retinal cells with the first light and illuminating the retinal cells with a second light after capturing the one or more second images, to cause the retinal cells to exhibit a second response. The method also includes capturing one or more third images of the retinal cells after illuminating the retinal cells with the second light. The method also includes generating an output, using the first images, the second images, and the third images. The output quantifies the first response and the second response.
Compositions are disclosed comprising: (a) a wound dressing; (b) at least one polyanionic polymer layer and at least one polycationic polymer layer disposed on a surface of the wound dressing, wherein a polyanionic polymer layer alternates with a polycationic polymer layer; and (c) a-sheet polypeptides disposed within the at least one polyanionic polymer layer and/or the at least one polycationic polymer layer; methods for their use, and methods for making the compositions.
C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61L 15/22 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux macromoléculaires
Methods for testing the effects of therapeutic compound candidates on a phenotypic organoid model is provided. Such a method includes steps of generating the phenotypic organoid model on a high throughput screening platform, treating the organoid with a therapeutic compound candidate, and testing one or more effects resulting from treatment with each of the therapeutic compound candidates. The testing method that has led to identification of a method for treating or preventing cysts is provided. That method may include contacting a population of cells with an inotrope, wherein the inotrope prevents cyst formation, shrinks existing cysts, or both. That method may be used to treat cystogenic diseases or conditions such as Polycystic Kidney Disease (PKD).
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
6.
APPARATUSES, SYSTEMS AND METHODS FOR SOLID IMMERSION MENISCUS LENSES
Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.
Disclosed and claimed is a medical delivery device with a separable housing comprising a durable component and a disposable component. The durable component comprises a handle portion of the device that may be connected to a compressed gas source to allow for the input of pressurized gas into the device. The disposable component comprises a cartridge containing a plurality of doses of biological or non-biological material and a supersonic barrel through which the dose is propelled out of the device and into the subject. When all of the doses in the cartridge have been administered, or when the device is to be used with a different subject, the cartridge is removed, and a new cartridge attached to the durable component.
Various devices, systems, and methods for performing personalized dosimetry of a patient receiving a radiopharmaceutical are described. In an example method, anatomic data is generated by performing a computed tomography (CT) scan on the patient when they are lying down and wearing a garment. Based on the anatomic data, locations of organs of the patient are determined with respect to one or more fiducial markers integrated with the garment. Detectors for detecting photons from a radiopharmaceutical are placed on the garment based on locations of the organs. Subsequently, the patient may be administered a dose of the radiopharmaceutical. When the patient wears the garment, the detectors may detect photons released from the decaying radiopharmaceutical that is distributed in the organs. The radiation dosage to the organs may be determined based on the detected photons.
A movable carriage configured to wrap a material sheet around a longitudinal component is presented. The movable carriage comprises a frame defining a center plane and an operating volume; side wheels within the operating volume configured to guide the material sheet against sides of a portion of the longitudinal component, when disposed within the operating volume and aligned with the center plane, as the movable carriage moves parallel to the center plane, the side wheels arranged as one or more opposing pairs about the center plane; and top wheels within the operating volume configured to guide the material sheet against the top of the portion of the longitudinal component as the movable carriage moves parallel to the center plane, the top wheels arranged as one or more opposing pairs about the center plane.
B29C 63/04 - Garnissage ou gainage, c.-à-d. application de couches ou de gainages préformés en matière plastiqueAppareils à cet effet avec des matières sous forme de feuilles ou de nappes par pliage, enroulement, cintrage ou par des opérations similaires
B29C 63/00 - Garnissage ou gainage, c.-à-d. application de couches ou de gainages préformés en matière plastiqueAppareils à cet effet
de novode novo designed human IL-17 (hIL-17) binding polypeptides, compositions thereof, and methods for their use in treating subjects. The provided compositions can modulate the interaction of hIL-17 with the hIL-17 receptor, and can be used in the management of inflammatory disorders including psoriasis, psoriatic arthritis, ankylosing spondylitis, active non-radiographic axial spondyloarthritis, multiple sclerosis, asthma, and rheumatoid arthritis.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 38/00 - Préparations médicinales contenant des peptides
A noninvasive blood-based biopsy measures surface protein receptors on specific circulating cell populations. Dysregulated quantities of specific surface protein receptors on specific circulating cells indicate the diseased tissue origin. Thus, specific circulating cells serve as proxies for diseased tissue cells as they are shed from such tissues. This approach can be used not only for preeclampsia but also for other vascular disorders where detecting surface protein receptors associated with particular disorders can increase sensitivity and disease specificity. Detection of a high level VEGFR1 on isolated circulating cells that are immunopositive for CD34 and CD31 can be used to identify and treat subjects suffering from preeclampsia.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
12.
Protein-Derived Peptide Multiplexes for Biomimetic Detection of VOC Profiles
The present disclosure provides peptides, chimeric molecular constructs, and compositions thereof, that can bind volatile organic compounds (VOCs) and be utilized to distinguish VOC profiles, e.g., indicative of disease, as well as related methods. A VOC-based gas sensing approach described in the present specification can be an effective screening tool, due, at least in part, to its speed, ease of use, sensitivity, specificity, and because it does not rely on binding to specific nucleic acid fragments or proteins to function.
G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
13.
De novo designed chlorophyll special pair proteins
Polypeptides are provide having an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:1-17, wherein the polypeptide binds to a chlorophyll (Chl) dimer, and scaffolds thereof.
Fusion proteins are provided that include (a) a stabilizer peptide including domains X1-X2, wherein (i) XI includes the amino acid sequence of SEQ ID NO: 1; and (ii) X2 is a first amino acid linker of between 5-20 amino acids in length; and (b) a truncated class I major histocompatibility complex (MHC) protein directly fused to the C-terminus of the stabilizer peptide, wherein the truncated MHC protein consists of residues 1-175, 1-176, 1- 177, 1-178, 1-179, 1-180, 1-181, 1-182, 1-183, 1-184, or 1-185 of a class I MHC protein, optionally wherein the truncated class I MHC protein comprises residues 6K, 81, 121, 104D, 105E, 106N, and 110V, and optionally wherein the truncated class I MHC protein comprises residue 84A.
The present disclosure provides an orthopedic brace including: a leg cuff; a footplate; and a strut coupling the leg cuff to the footplate. The strut includes a first member with opposite first and second ends, a second member coupled at a first end to the first end of the first member, and a third member coupled at a first end to the second end of the first member. The brace further includes a first adjustable coupling element connecting the second member to the first member, and a second adjustable coupling element connecting the third member to the first member. The stiffness and/or bending location of the strut is adjustable based on the position of at least one of the adjustable coupling elements along the length of the first member.
A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
16.
MANUFACTURING SYSTEMS AND METHODS FOR SHAPING AND ASSEMBLING FLEXIBLE STRUCTURES
A manufacturing system and method for determining and optimizing shaping locations and shaping inputs and shaping a component using the shaping locations and shaping inputs includes steps of: determining shaping locations on the component for application of shaping inputs that change an as-built shape of the component toward a target shape of the component and determining the shaping inputs to be applied to the component at the shaping locations to change the as-built shape of the component toward the target shape of the component; applying the shaping inputs to the component at the shaping locations on the component; and changing the as-built shape of the component to within a predetermined tolerance of the target shape.
G06F 30/23 - Optimisation, vérification ou simulation de l’objet conçu utilisant les méthodes des éléments finis [MEF] ou les méthodes à différences finies [MDF]
G06F 119/18 - Analyse de fabricabilité ou optimisation de fabricabilité
A rolling metamaterial cell for a helmet is disclosed herein. The cell can include an upper semi-spherical portion configured to be operably coupled to an outer shell of the helmet; a lower semi-spherical portion configured to be operably coupled to an inner layer of the helmet; a first deformable structure adjacent to the upper semi-spherical portion; and a second deformable structure adjacent to the rounded lower portion. The first and second deformable structures are configured to compress upon impact force applied to the outer shell of the helmet, wherein the compression rotates a central ring between the deformable structures relative to the upper and lower semi-spherical portions. A helmet can include an outer shell, an inner shell arranged inward from the outer shell, and a plurality of the rolling metamaterial cells arranged therebetween.
Methods and systems to reduce symptoms of cerebral palsy in children are disclosed herein. In one embodiment, a method for alleviating spasticity of a lower extremity caused by a brain injury includes attaching at least one electrode on a surface of patient's skin, proximate to patient's spinal cord. The method also includes subjecting the patient to a regimen of training that improves walking of the patient; applying a series of pulses to the at least one electrode while the patient is in training; and in response to applying the series of pulses to the at least one electrode, inducing stimulation in the spinal cord that alleviates spasticity of the lower extremity.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A63B 22/02 - Appareils d'exercice spécialement adaptés à l'entraînement du système cardio-vasculaire, pour exercer l'agilité ou la coordination des mouvements avec des tapis roulants sans fin
19.
SYSTEMS AND METHODS FOR CHARACTERIZATION OF POLYCYSTIC KIDNEY DISEASE
Microfluidic systems, kits, and methods for characterization of polycystic kidney disease (PKD) are described. In an embodiment, the microfluidic system includes a flow device comprising an inlet, an outlet, and a channel comprising a functionalized site configured for cell culture. In an embodiment, a genetically modified (GM) human kidney organoid is cultured at the functionalized site, optionally in the presence of a fluidic flow, to produce PKD cysts for use as a model system for characterization of mechanisms of PKD onset, progression, diagnosis, and response to treatment.
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
20.
METHOD FOR EXPRESSING A MUSCLE-SPECIFIC GENE AND CASSETTES FOR SAME
The invention described here contains a nucleic acid expression cassette comprising a transcriptional regulatory region operably linked to a nucleic acid sequence encoding a FKRP, an RNA transcript comprising a modified 5′ and/or 3′ untranslated region (UTR) that will be utilized to treat a variety of FKRP-mediated diseases.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
Synthetic genetic platforms in eukaryote cells (such as yeast) is described. A representative synthetic genetic platform includes a eukaryote cell genetically modified to express an auxin receptor, an auxin response factor, and a reporter, as well as a fusion construct including a Lis1 Homology (LisH) domain fused to an auxin-responsive protein. The synthetic genetic platforms can be used, for instance, to understand developmental and pathological LisH domain variants, and to test bioactive molecules for LisH domain activity.
A diagnostic system for analyzing an analyte is described. In an embodiment the diagnostic system includes a fluidic single-use disposable and a base cooperatively coupleable thereto. In an embodiment, the fluidic single-use disposable comprises a sample processing subcomponent configured to receive a sample and emit signal light if the sample comprises an analyte; a fluidic single-use disposable housing encompassing the sample processing subcomponent, the fluidic single-use disposable housing comprising: a first major side; and a fluidic single-use disposable viewing window disposed in the first major side and positioned to allow light emitted from the sample processing subcomponent to pass through the fluidic single-use disposable viewing window. In an embodiment, the base comprises a base housing comprising: a first major side shaped to cooperatively couple with the first major side of the fluidic single-use disposable housing.
The Board of Trustees of the Leland Stanford Junior University (USA)
University of Washington (USA)
Inventeur(s)
Garcia, Kenan Christopher
Baker, David
Janda, Claudia Yvonne
Dang, Luke
Moody, James Daniel
Abrégé
Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
24.
Polypeptide Assemblies and Methods for the Production Thereof
The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
Chromophores with large hyperpolarizabilities, films with electro-optic activity comprising the chromophores, and electro-optic devices comprising the chromophores are disclosed.
C07D 307/28 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle non condensés avec d'autres cycles comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
Inserts for a specimen collection tube and kits for collecting and metering biofluids are described. In an example, the insert comprises a fluidic channel separator defining an aperture, wherein the aperture is configured to limit flow of a fluid therethrough by hydrostatic forces between the fluid and the aperture; and a plurality of legs extending outwardly from a side of the fluidic channel separator. In an example, the kit comprises a specimen collection tube and an insert sized and shaped to fit in the sample collection tube, such as to meter a biofluid provided to the specimen collection tube. In an example, the insert comprises a flange extending from a disc of the fluidic channel separator.
G01N 1/18 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide avec mesures prises pour diviser des échantillons en plusieurs parties
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01D 33/00 - Filtres avec éléments filtrants mobiles au cours de l'opération de filtration
THE ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (USA)
Inventeur(s)
Fuller, James Thomas
Fuller, Deborah Lynn
Barker, Bridget M.
Settles, Erik W.
Erasmus, Jesse H.
Abrégé
A trivalent vaccine induces robust antibody and mucosal and systemic IFN-γ and Th17 T cell responses against Coccidioides and affords complete protection from fungal dissemination and disease. The combination of the three antigens of this trivalent vaccine can exert synergistic protection against lethality, disease and fungal dissemination. These robust responses can be further enhanced by use of one or more additional antigens described herein.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
C07K 14/37 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12N 15/80 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons
C12N 15/31 - Gènes codant pour des protéines microbiennes, p. ex. entérotoxines
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
28.
SYSTEMS AND METHODS OF PHENOTYPE CLASSIFICATION USING SHOTGUN ANALYSIS OF NANOPORE SIGNALS
A computer-implemented method of phenotype classification is provided. A computing system receives a plurality of segmented events generated by a plurality of nanopores in response to a sample being applied to the plurality of nanopores, wherein each segmented event of the plurality of segmented events represents ionic current changes during a protein interaction with a nanopore of the plurality of nanopores. The computing system processes the plurality of segmented events to create at least one set of model input data. The computing system provides the at least one set of model input data as input to at least one classifier model to generate a classification of the sample. The computing system transmits the classification for presentation on a display device.
In an embodiment, the present disclosure pertains to an organ-specific wireless optogenetic device. In some embodiments, the device includes an electronic circuit, such that the electronic circuit is configured to harvest and convert radio frequency (RF) energy into optical energy and a tether having a μLED, where the μLED illuminates targeted regions in the organ. In an additional embodiment, the present disclosure pertains to a method of treating obesity. In general, the method includes implanting an organ-specific wireless optogenetic device into a subject, activating an RF-power system to produce RF energy, harvesting, by the organ-specific wireless optogenetic device, the RF energy, converting, by the organ-specific wireless optogenetic device, the RF energy into optical energy, illuminating, by the μLED, targeted regions in the stomach of the subject, and stimulating nerve endings to thereby suppress appetite in the subject.
Compressed meta-optical encoder for image classification, and associated systems and methods are presented. In one embodiment, a convolutional neural network (CNN) system for image classification includes a meta-optics having a plurality of convolutional kernels. Each convolutional kernel includes a plurality of nanostructures. The plurality of kernels are configured for convolving source images by applying their respective point spread functions (PSFs) to the source images. The system also includes an image capturing camera configured for capturing convolved images, and an electronic backend software configured for classifying the source images based on the convolved images.
G02B 1/02 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de cristaux, p. ex. sel gemme, semi-conducteurs
This disclosure describes examples of systems, apparatuses, and methods for performing wireless communication using thermal noise of one or more components of the systems. An example method includes modulating thermal noise in a transmitter based on data to provide a signal and transmitting the signal including the data as output of the transmitter.
SEATTLE CHILDREN’S HOSPITAL D/B/A SEATTLE CHILDREN’S RESEARCH INSTITUTE (USA)
UNIVERSITY OF WASHINGTON (USA)
Inventeur(s)
Tretiakov, Mikhail
Abrégé
A fracture reduction tool for performing bone fracture reduction is disclosed herein. In one example, the fracture reduction tool includes a first baseplate, a second baseplate, and a flexible linker coupled between the first baseplate and the second baseplate, wherein the flexible linker comprises a gooseneck component configured to move and bend in multiple degrees of freedom.
Examples described herein may image a tissue sample while tracking a surface of the tissue sample. At least one image of the tissue sample may be obtained using a 3D microscope system, the at least one image including a surface of the tissue sample. A position of the surface of the tissue sample may be detected based on the at least one image. A signal indicative of the position may be provided to control an axis of the microscope to obtain a subsequent image at a different lateral position of the tissue sample having a surface of the sample at a predetermined position within a frame of the subsequent image. Techniques and systems for positive margin identification in a tissue sample are also described.
Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
35.
FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
36.
VAN DER WAALS HETEROSTRUCTURE TRANSPORT DEVICE FOR GATE-TUNABLE QUANTUM ANOMALOUS HALL STATE
A multiple gate system for realizing the quantum anomalous Hall effect, including a top channel electrode which controls carrier density and electric field in a conduction channel, a first dielectric layer for the top channel gate, a patterned contact gate electrode which controls earner density on the contact and screens the top channel electrode's electric field on the contact, and a second dielectric layer for the contact gate, an electrically tunable material comprising semiconducting molybdenum ditelluride in the form of a first atomic sheet and a second atomic sheet, wherein first atomic sheet is rotated planarly from the second atomic sheet by about 2.5 to about 5 degrees, to form a geometrically stacked homobilayer moiré superlattice configured to host ferromagnetic states that spontaneously break time-reversal symmetry, where a perpendicular electric field is applied to the electrically tunable material, tuning the quantum anomalous Hall effect.
H10D 62/10 - Formes, dimensions relatives ou dispositions des régions des corps semi-conducteursFormes des corps semi-conducteurs
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (USA)
Inventeur(s)
Murphy, Sean C.
Chavtur, Christopher R.
Abrégé
Candida aurisCandida aurisCandida aurisC. aurisC. aurisCandidaC. aurisC. aurisC. aurisC. auris screening, and can be adapted in high-throughput laboratory approaches.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
Embodiments of the present disclosure provide systems, devices, and methods for solving combinatorial optimization problems using a device that functions as a CMOS Ising machine. An example device includes circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation. The circuitry for linear operation includes a plurality of SRAM cells in an SRAM cell array that store values of a coupling matrix. In some embodiments, circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation may be fabricated on a semiconductor substrate. In some embodiments, the device may include a feedback loop including circuitry for linear operation, circuitry for noise addition, and circuitry for nonlinear operation, wherein the circuitry for linear operation is coupled to the circuitry for nonlinear operation.
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
An example method includes transmitting, by a single ultrasound transducer, an incident ultrasound signal and detecting, at least partially from an object within a ringdown range of the single ultrasound transducer and by the single ultrasound transducer, a received ultrasound signal. A ringdown artifact is removed from data indicative of the received ultrasound signal. Based on removing the ringdown artifact, the object is analyzed based on the data.
In one aspect, a method described herein can be used for laser carrier recovery in optical coherent communication systems utilizing quadrature amplitude modulation (QAM) at a receiver. The method includes receiving, at the receiver, a transmitted signal modulated using QAM and a local oscillator (LO) signal. The method includes detecting, at the receiver, a phase offset between the transmitted signal and the LO signal. The method includes compensating, at the receiver, by generating an error signal based on the average power and/or voltage difference between the In-phase (I) and Quadrature-phase (Q) paths of the received signal at the receiver, where the error signal compensates for the phase offset between the transmitted signal and the LO signal.
H04B 10/07 - Dispositions pour la surveillance ou le test de systèmes de transmissionDispositions pour la mesure des défauts de systèmes de transmission
43.
SYSTEMS AND METHODS FOR THREE-DIMENSIONAL RECONSTRUCTION OF ENDOSCOPIC AND CYSTOSCOPIC INFORMATION
Improved methods for quickly and completely reconstructing the interior surface of the bladder, based on images/video generated via cystoscopy, are provided. These methods include the training of a Neural Radiance Field (NeRF) model based on the images/video to represent the optical properties of the entire interior space of the bladder. The trained NeRF can then be used to quickly render arbitrary images of the inside of the bladder, which can then be composited into a complete model of the geometry and texture of the entire interior of the bladder. Improvements described herein, including the use of an actuated endoscope to control the location, orientation, and velocity of the endoscope, enable faster and more accurate training of the NeRF model, leading to full reconstruction of the entire interior surface of the bladder in minutes or less.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
G06T 17/10 - Description de volumes, p. ex. de cylindres, de cubes ou utilisant la GSC [géométrie solide constructive]
G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G06T 5/94 - Modification de la plage dynamique d'images ou de parties d'images basée sur les propriétés locales des images, p. ex. pour l'amélioration locale du contraste
G06T 7/579 - Récupération de la profondeur ou de la forme à partir de plusieurs images à partir du mouvement
The present disclosure is generally directed to macrocyclic oligoamides useful in the inhibition of HDAC6, and methods for treating diseases that are ameliorated by the inhibition of HDAC6.
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
Disclosed herein are nanostructures and their use, where the nanostructures include
(a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides;
(b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide;
wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and
wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
Dynamic mode decomposition technique for doppler-based imaging of cavitation bubbles in pulsed high intensity focused ultrasound is described. A method for imaging transient cavitation bubbles in a tissue of a patient using ultrasound imaging includes: generating a burst of therapy ultrasound waves by a focused therapy transducer; and generating cavitation bubbles by the burst of therapy ultrasound waves at a target region that is a focal region of the tissue. After generating a plurality of the gas bubbles at the target region and within a time period of the dissolving process, imaging ultrasound pulses are generated by an imaging probe. Generating ultrasound images as B-scan images based on returning ultrasound signals. The filtering is configured for isolating representations of dissolving gas bubbles from representations of surrounding tissue, and determining spatial and temporal attributes of the sub-mm scale gas bubbles.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
47.
Sensing System for Monitoring Prosthetic Socket Fit
The present disclosure provides methods for fabricating an instrumented prosthetic socket including a. layered, fabrication with inductive sensors positioned between electrically insulating layers of the socket. The present disclosure further provides methods for tracking of position relationship between socket and socket liner using inductive sensor arrays, and inductive sensor configurations for placement on a curved surface.
An example method involves receiving a plurality of data streams, including a first data stream and a second data stream, and an incident carrier signal. The first data stream is packetized into a first set of Bluetooth packets, and the second data stream into a second set of Bluetooth packets. These Bluetooth packets are then backscattered by a backscatter modulator using an incident carrier signal, with the first set of packets backscattered in a first Bluetooth channel and the second set in a second Bluetooth channel. In this manner, a backscatter device may backscatter into multiple Bluetooth channels simultaneously.
H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
H04B 7/00 - Systèmes de transmission radio, c.-à-d. utilisant un champ de rayonnement
H04B 1/525 - Dispositions hybrides, c.-à-d. dispositions pour la transition d’une transmission bilatérale sur une voie à une transmission unidirectionnelle sur chacune des deux voies ou vice versa avec des moyens de réduction de la fuite du signal de l’émetteur vers le récepteur
H04B 5/00 - Systèmes de transmission en champ proche, p. ex. systèmes à transmission capacitive ou inductive
Disclosed herein are polypeptides that bind to the epithelial cell adhesion molecule (EpCAM) and programmed death-ligand I (PDL 1) receptors, nucleic acids encoding them, and methods for their use in treating or limited development of cancer, auto immune disease, or inflammation. The disclosure further provides nucleic acids encoding a polypeptide of the disclosure: expression vector comprising a nucleic acid of the disclosure operatively linker to a suitable regulatory control element, host cells comprising a polypeptide, fusion protein, nucleic acid, or expression vector of any embodiment of the disclosure, and pharmaceutical compositions, comprising the polypeptide, fusion protein, nucleic acid, expression vector, or host cell of any embodiment; and a pharmaceutically acceptable carrier.
Nanoporous selective sol-gel ceramic membranes, selective-membrane structures, and related methods are described. Representative ceramic selective membranes include ion-conductive membranes (e.g., proton-conducting membranes) and gas selective membranes. Representative uses for the membranes include incorporation into fuel cells and redox flow batteries (RFB) as ion-conducting membranes.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur supportSupports pour membranes
B01D 71/28 - Polymères de composés vinylaromatiques
B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
C04B 35/10 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxyde d'aluminium
C04B 35/14 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base de silice
C04B 35/48 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxydes de zirconium ou d'hafnium ou de zirconates ou d'hafnates
A channel crawler has a carriage, a stabilizing mechanism, and a deployment mechanism. The carriage has wheels configured to engage surfaces that define a channel through which the carriage is configured to move. The stabilizing mechanism is configured to extend from the carriage and engage a non-horizontal surface of the channel in a manner restricting unintended movement of the carriage in one or more directions. The deployment mechanism is configured to fit within the carriage when retracted, and selectively deploy an operational device from a stowed position within the carriage to a deployed position outside the channel for performing an operation in relation to at least one of structure and hardware proximate the channel.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, conducting programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, and printed materials distributed therewith; Educational services, namely, conducting personal training of individuals to conduct programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, downloadable implementation toolkits distributed therewith, and distribution of training material in connection therewith
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
downloadable software application connecting patients with health care teams for supporting the increase of prescribed physical activity for health. software platform connecting patients with health care teams in support of increasing prescribed physical activity for health Sports medicine services
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, conducting programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, and printed materials distributed therewith; Educational services, namely, conducting personal training of individuals to conduct programs in the field of mental health in order to help older adults develop the skills they need to maintain their health, happiness, and independence, downloadable implementation toolkits distributed therewith, and distribution of training material in connection therewith
55.
RADIO FREQUENCY (RF) ANTENNAS FOR COMMUNICATION THROUGH WATER, SEA ICE, OR BOTH
In one aspect, an antenna may include a waveguide with a dielectric material disposed within the waveguide, where the dielectric material may include a dielectric constant matched or near-matched to a dielectric constant of liquid water. The antenna can selectively be configured to communicate using one or more very high frequency (VHF) or one or more ultra high frequency (UHF) radio frequencies through liquid water.
H01Q 1/34 - Adaptation pour l'utilisation dans ou sur les navires, les sous-marins, les bouées ou les torpilles
H01Q 1/28 - Adaptation pour l'utilisation dans ou sur les avions, les missiles, les satellites ou les ballons
H01Q 13/00 - Cornets ou embouchures de guide d'ondeAntennes à fentesAntennes guide d'onde à ondes de fuiteStructures équivalentes produisant un rayonnement le long du trajet de l'onde guidée
H04B 13/02 - Systèmes de transmission dans lesquels le milieu de propagation est constitué par la terre ou une grande masse d'eau la recouvrant, p. ex. télégraphie par le sol
56.
SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST OPIOIDS
The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes opioids such as fentanyl and carfentanil. Also provided are methods of making and using these constructs.
This disclosure relates to methods and systems for imaging biopsy samples. The system for imaging biopsy samples comprises a window and an imaging device. The window comprises an inflexible and optically clear material. The window is configured to compress a sample disposed in a biopsy needle. The imaging device is configured to maintain a constant working distance to the flattened tissue surface while scanning. The imaging device is configured to capture one or more images of the sample through the window.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
58.
METHOD TO IMPROVE CELL VIABILITY OF CARDIOMYOCYTES
The methods and compositions relate to the improvement of cell viability regarding in vitro differentiated cardiomyocytes. Addition of ROCK-inhibitors to pluripotent stem cells in combination with factors modulating differentiation pathways improves in-vitro differentiated cardiomyocyte viability and fitness.
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
An example system includes a plurality of microphones placed proximate a head of a user. The microphones receive acoustic signals from the environment and generate corresponding input audio signals. The example system includes a trained machine learning model. This model receives input audio signals and extracts target audio signals corresponding to sources within a specified threshold distance from the user. These target audio signals are then provided to the speaker for playback to the user. This may create a sound bubble for the user.
G10L 21/0308 - Séparation du signal de voix caractérisée par le type de mesure du paramètre, p. ex. techniques de corrélation, techniques de passage par zéro ou techniques prédictives
Systems and methods for culture of human kidney organoids as a model system for characterizing kidney pathologies and implementing therapeutics for conditions that affect the kidney. A model system for characterization of a pathophysiology includes a culture of human kidney organoids and an organoid culture medium. The organoids may include one or more genome edits as part of an approach for studying genetic factors involved with a pathological process. The culture may include one or more other factors, such as pathological agents and/or anti-pathological agents, for development and evaluation of therapeutics. The approaches may be used for implementation of compositions and methods for virally transducing the kidney or a subset of cells or cell types thereof.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12N 9/48 - Hydrolases (3.) agissant sur les liaisons peptidiques, p. ex. thromboplastine, aminopeptidase de la leucine (3.4)
62.
De Novo Designed Stimulus-responsive Two-state Hinge Proteins
Polypeptides having an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1-20 and 33-58 are provided, fusion proteins thereof, kits thereof, and methods for their use as sensing devices and for other uses.
A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a baffle section configured to start the projectile in the ram accelerator without an obturator. The ram accelerator generally includes a tube having a projectile bore; and a baffle section operably coupled to a proximal end of the tube. The baffle section has an annular baffle wall defining a central bore axially aligned with the projectile bore; and a propellant chamber arranged adjacent to the annular baffle wall, wherein the propellant chamber is configured to enclose a propellant. The propellant can be ignited as the projectile passes through the baffle section by pressure created by the projectile, by an ignition source, or by a flame carried by the projectile to start the ram acceleration of the projectile.
F41A 1/02 - Propulsion de projectiles en survitesse utilisant des moyens successifs pour augmenter la force propulsive, p. ex. utilisant la combustion de plusieurs charges propulsives, allumées l'une après l'autre et disposées le long du tube de l'armePropulsion multi-étages de projectiles
64.
GAS QUENCHING TECHNIQUE FOR CONTROLLABLE CRYSTAL GROWTH MECHANISMS
A tool for producing films comprising a chuck configured to move a substrate, a slot die head configured to deposit one or more liquids onto the substrate, an air knife coupled to a gas source with a supply tube, the air knife configured to blow gas onto the substrate, a gantry configured to position the air knife, one or more controllers configured to collect one or more air knife data, one or more in-situ configured to determine an optimal position of the air knife, and a processor configured to receive position data from the in-situ monitor, receive one or more air knife data from the one or more controllers, analyze the received data with one or more machine learning/artificial intelligence (ML/AI) algorithms to predict a coating condition, compare the coating condition with a desired coating condition, and adjust one or more parameters of the air knife to meet the desired coating condition.
B05C 5/02 - Appareillages dans lesquels un liquide ou autre matériau fluide est projeté, versé ou répandu sur la surface de l'ouvrage à partir d'un dispositif de sortie en contact, ou presque en contact, avec l'ouvrage
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 39/14 - Moulage par coulée, c.-à-d. en introduisant la matière à mouler dans un moule ou entre des surfaces enveloppantes sans pression significative de moulageAppareils à cet effet pour la fabrication d'objets de longueur indéfinie
B05C 5/00 - Appareillages dans lesquels un liquide ou autre matériau fluide est projeté, versé ou répandu sur la surface de l'ouvrage
65.
GENERATING AND UTILIZING ADULT HEPATOCYTE ORGANOIDS
Techniques for generating and utilizing adult hepatocyte organoids are described. An example method includes generating an organoid by culturing hepatocytes obtained from an adult donor in a hepatocyte culture medium. The hepatocyte culture medium includes a basal medium and 5 μM of a TGF-β inhibitor.
Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel.
Extendable and flexible drive shaft members and drive shaft assemblies include circumferentially distributed anisotropic mechanisms configured to accommodate extension and flexure. A drive shaft member includes anisotropic mechanisms that are interconnected and distributed circumferentially around a longitudinal centerline of the drive shaft member. Each of the anisotropic mechanisms is configured to accommodate extension of the anisotropic mechanism parallel to the longitudinal centerline. The anisotropic mechanisms combine to transmit a torque along the longitudinal centerline.
High-throughput methods for screening candidate DNA sequences for functionality as genetic insulators in plant genetic environments, as well as genetic insulators identified by the methods and plants that include the genetic insulators as transgenic elements. Genetic insulators can be cloned with transgenes, and introduced to plant cells, tissues, and organisms, for tighter control of transgene expression.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable software, namely in molecular modeling of protein structures Software design for the purposes of molecular modeling of protein structures.
Seattle Children's Hospital d/b/a/ Seattle Children’s Research Institute (USA)
Inventeur(s)
Von Saint Andre-Von Arnim, Amelie
Diblasi, Robert Mariano
Poli, Jonathan Arthur
Sonaike, Ibukun
Yanay, Ofer
Vamos, Andrew
Abrégé
A system includes a container configured to contain a liquid. The system also includes a tubing apparatus having a first port configured for connection to a gas source, a second port configured for connection to a patient interface, and a third port configured for submersion within the liquid. The system also includes an actuator configured to move the third port vertically within the container. A method includes flowing gas into the first port of the tubing apparatus to the patient interface via the second port of the tubing apparatus. The method also includes moving the third port of the tubing apparatus vertically within the container such that an amount of the liquid in the container that is above the third port changes, thereby changing a pressure at the patient interface.
Compositions, nucleic acid molecules and methods for inducing retinal regeneration and reprogramming of Müller glia (MG) into retinal ganglion cells in a subject are described. Developmental retinal ganglion cell (RGC) transcription factors Pou4f2 and Islet1 increase the Ascl1-induced neurogenic capacity of MG. The combination of Ascl1, Pou4f2 and Islet1 stimulates MG to generate bipolar cells and RGC-like neurons. Likewise, the transcription factor Onecut1, which is expressed in developing retinal cells, but not in MG, induces MG to generate RCG-like cells. Additional transcription factors that can be used include Irx2, Irx5, Neurod2, Ebf1, and Tcf3. MG-derived RGCs can exhibit action potentials in vivo, and display chromatin profiles similar to developing RGCs.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Polypeptides having an amino acid sequence at least 50% identical to, and identical at least at one identified interface position, to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-44, and polypeptides having an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NO: 45-58, are provided, as well as fusion proteins thereof, nanoparticles thereof, and methods for treating or limiting development of an infection.
e.g.e.g., dNTPs that differ chemically or physically from canonical dNTPs), in place of canonical dNTPs, that are incorporated into copies of the target sequences in place of canonical dNTPs. Due to the presence of the analog dNTPs in the copy sequences, the copy sequences exhibit different electrical signatures compared with the target sequences and can be used for improving confidence in base-calling and reducing the complexity of the sequencing problem.
A ram accelerator for accelerating a projectile is provided. The ram accelerator includes a first tube body having a first projectile bore, a second tube body having a second projectile bore axially aligned with the first projectile bore, and a baffle positioned between and operably coupling the first and second tube bodies. The baffle can have an annular baffle wall defining a central bore that is axially aligned with the first and second projectile bores, and a chamber arranged adjacent to the annular baffle wall. The chamber can extend radially outward from the central bore and the annular baffle wall can be configured to sweep a combustion wave relative to the projectile to prevent the combustion wave from traveling ahead of the projectile, leading to an unstart mechanism of the projectile in the ram accelerator.
Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
Use of 4-(Propan-2-yl)-N-(pyridin-4-yl)benzamide (C15H16N2O) and similar compounds to treat pain and reduce the aversiveness of negative stimuli is described. The treatments can alleviate pain, anxiety, and depression. Such treatment may reduce the perception of pain or experience of an aversive reaction to a stimulus. The treatments can activate particular portions of the brain region, such as a subpallium or a telencephalic region.
A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
79.
Computational Design of Self-Assembling Cyclic Protein Homo-oligomers
A61K 38/03 - Peptides ayant jusqu'à 20 amino-acides dans une séquence indéterminée ou partiellement déterminéeLeurs dérivés
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 15/30 - Ciblage de médicament à l’aide de données structurellesPrévision d’amarrage ou de liaison moléculaire
Conditionally active receptor agonists that, when activated, bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αcheterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Nalfurafine ester derivatives, formulations that include the nalfurafine ester derivatives, and methods for using the nalfurafine ester derivatives and formulations for promoting stress-resilience.
Techniques described herein are directed to performing error correction for enhanced aerospace safety and navigation. For example, a carrier board used in a sensor pod system for a vehicle can include a feedback bus, a control output bus, and a processing device. the feedback bus can receive inputs from interface boards. The control output bus can provide outputs to the interface boards. The processing device can control a serial communications module that can manage operation of the feedback bus and the control output bus. The processing device can also implement an error correction system that can analyze sensor parameters received over the feedback bus. The error correction system can generate analyzed output including error corrections for the sensor parameters for outputting by the control output bus. The error correction system may determine, based on the analyzed sensor parameters, error types associated with errors with the inputs from the interface boards.
G01C 25/00 - Fabrication, étalonnage, nettoyage ou réparation des instruments ou des dispositifs mentionnés dans les autres groupes de la présente sous-classe
H04N 7/035 - Circuits pour les données numériques autres que des données d'image, p. ex. pour le découpage du signal de données, pour la régénération du signal d'horloge de données, pour la détection ou la correction d'erreurs du signal de données
G01D 3/036 - Dispositions pour la mesure prévues pour les objets particuliers indiqués dans les sous-groupes du présent groupe pour atténuer les influences indésirables, p. ex. température, pression sur les dispositions de mesure elles-mêmes
G01D 5/244 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant les caractéristiques d'impulsionsMoyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques produisant des impulsions ou des trains d'impulsions
G01D 18/00 - Test ou étalonnage des appareils ou des dispositions prévus dans les groupes
B64D 45/00 - Indicateurs ou dispositifs de protection d'aéronefs, non prévus ailleurs
G01C 23/00 - Instruments combinés indiquant plus d’une valeur de navigation, p. ex. pour l’aviationDispositifs de mesure combinés pour mesurer plusieurs variables du mouvement, p. ex. la distance, la vitesse ou l’accélération
G06N 3/044 - Réseaux récurrents, p. ex. réseaux de Hopfield
G06T 7/80 - Analyse des images capturées pour déterminer les paramètres de caméra intrinsèques ou extrinsèques, c.-à-d. étalonnage de caméra
Flat-band meta-optics for efficient photodetectors, and associated systems and methods are described. In one embodiment, a meta-optics photodetector that is configured for detecting incoming light includes a patterned structure configured for illumination by incoming light. The patterned structure is patterned at a sub-wavelength scale. The meta-optics photodetector also includes an absorber configured for generating electrical charges in response to incoming light. A p-n junction is coupled to the absorber and configured for carrying away the electrical charges as an electrical signal.
The present disclosure provides a device comprising a first connector including a first elongated hollow member configured to be positioned at least partially within a lumen of a proximal portion of a tube. The first connector provides a clamping force to the proximal portion of the tube. The device also includes a second connector configured to be removably coupled to the first connector. The second connector including a second elongated hollow member configured to be positioned at least partially within a lumen of a distal portion of the tube. The proximal portion of the tube is separated from the distal portion of the tube when the first connector is disconnected from the second connector, and the lumen of the proximal portion of the tube is fluidically connected with the lumen of the distal portion of the tube when the first connector is removably coupled to the second connector.
Alpha-sheet polypeptide multimers, and polypeptides for making multimers, compositions and medical devices including them, and their use for treating and diagnosing amyloid diseases or amyloid-associated diseases are disclosed.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
86.
PROTECTIVE MONOCLONAL ANTIBODIES TO PSEUDOMONAS AERUGINOSA
SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (USA)
Inventeur(s)
Pepper Pew, Marion
Takehara, Kennidy
Thouvenel, Christopher
Rawlings, David J.
Hale, Malika Rose
Abrégé
aeruginosa aeruginosaP.aeruginosaaeruginosa. The binding proteins or antibodies or derivatives thereof disclosed herein have a high affinity to a wide range of PcrV epitopes. In an embodiment, the binding proteins disclosed herein are effective in limiting a PA infection.
A system for detecting a biological target in a sample, including a sensor comprised of single-walled nanotubes coating a sample substrate, where the sensor includes a sensing electrode and a control electrode, and an analyzer configured to accept the sensor including a controller configured to measure a resistance of the sensing electrode and a resistance of the control electrode and compare the resistance of the sensing electrode to the resistance of the control electrode. Additionally, a method of detecting a biological target with the system including placing a sample into an analyzer, inserting a sensor made of single-walled carbon nanotubes into the analyzer, wherein the sensor includes a sensing electrode and a control electrode, submerging the sensing electrode into the sample, submerging the sensing electrode into a washing solution, measuring the resistance of the sensing electrode and the control electrode, and comparing the resistances.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
89.
DE NOVO DESIGN OF POTENT AND SELECTIVE INTERLEUKIN MIMETICS
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Silva Manzano, Daniel Adriano
Yu, Shawn
Ulge, Umut
Baker, David
Garcia, Kenan Christopher
Spangler, Jamie
Walkey, Carl
Abrégé
De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.
Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.
A61L 29/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A method of fabricating a wearable and elastically stretchable thermoelectric generator or other thermoelectric device can involve arranging thermoelectric pellets and printing a thermal insulation material alongside and/or around the thermoelectric pellets to form a core layer. The core layer can be cured, and a liquid metal can be selectively deposited on the thermoelectric pellets to form contact points. Printing conductive ink can form stretchable electrical interconnects that define connections among the thermoelectric pellets via the contact points to form an initial middle layer that includes the stretchable electrical interconnects. Printing a thermal interface material may form an initial outer layer positioned between the initial outer layer and an initial side of the core layer to form a layered assembly. The layered assembly may be inverted and receive additional printed layers building away from the core layer, such as an additional interconnect layer and an additional thermal interface layer.
H10N 10/17 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier fonctionnant exclusivement par les effets Peltier ou Seebeck caractérisés par la structure ou la configuration de la cellule ou du thermocouple constituant le dispositif
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
SAMSUNG ELECTRONICS CO.,LTD. (République de Corée)
University of Washington (USA)
Inventeur(s)
Min, Jaehong
Krishnamurthy, Arvind
Zhao, Chenxingyu
Abrégé
Provided is a method of operating a storage system including a host device, which includes a zone manager, and a storage device. The method includes allocating, by the zone manager, a first essential write resource, a second essential write resource, a first spare write resource, and a second spare write resource to a first logical zone, allocating, by the zone manager, a third essential write resource, a fourth essential write resource, a third spare write resource, and a fourth spare write resource to a second logical zone, and reallocating, by the zone manager, the first spare write resource and the second spare write resource to the second logical zone.
Polypeptides having an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-381, not including any amino acid insertions at identified loop positions, are provided that bind to II- 6R, GP130, or IL-1R, and which can be used to treat or limit development of Cytokine release syndrome and other disorders.
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
98.
INTRAUTERINE SYSTEMS COMPRISING ANTI-INFECTIVES FOR STEADY-STATE ACCUMULATION TO DISTAL EXTRAUTERINE TISSUE
An intrauterine system configured to be retained in a uterus of a patient, the intrauterine system including a delivery system configured to deliver one or more active compounds, where the one or more active compounds have non-systemic extrauterine biological targets. Further, a method of using the intrauterine system, including retaining the intrauterine system in a uterus, and delivering the one or more active compounds to non-systemic extrauterine biological targets in the lower female reproductive tract (LFRT) or the rectum.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61K 31/522 - Purines, p. ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p. ex. hypoxanthine, guanine, acyclovir
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
Polypeptides are disclosed having an amino acid sequence at least 50% identical to the amino acid sequence of SEQ ID NO:1, wherein, relative to SEQ ID NO:1, residue 43 is I, residue 95 is Q, and residue 128 is L, fusion proteins thereof, kits thereof, and methods for using the polypeptides for treating a disorder associated with cortisol, or for detecting cortisol in a biological sample.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/74 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des hormones
100.
GENERATION OF DEOXYADENOSINE TRIPHOSPHATE DONOR CELLS AND USES THEREOF
Provided herein are compositions and methods directed toward the discovery of improved methods for generating deoxyATP (dATP) in cells that can be delivered to a graft site in the heart to enhance cardiac function.
