St. Vincent's Hospital (Melbourne) Limited (Australia)
University of Wollongong (Australia)
Swinburne University of Technology (Australia)
The University of Melbourne (Australia)
Inventor
Choong, Peter F.M.
Gambhir, Sanjeev
Wallace, Gordon George
Duchi, Serena
Onofrillo, Carmine
O'Connell, Cathal D.
Di Bella, Claudia
Moulton, Simon Edward
Abstract
The present invention relates to a functionalised polymer, methods of preparing the functionalised polymer, and compositions comprising the functionalised polymer. The present invention also relates to methods of using the functionalised polymer including for forming a polymer composition comprising cells from a tissue sample and for cell therapy.
ST VINCENT'S HOSPITAL (MELBOURNE) LIMITED (Australia)
Inventor
Choong, Peter, Fook Meng
Duchi, Serena
Onofrillo, Carmine
Wallace, Gordon, George
Beirne, Stephen, Thomas
Gambhir, Sanjeev
Gailer, Daniel, John
Di Bella, Claudia
Abstract
An apparatus for use in preparation of a composition for treatment or repair or regeneration of tissue comprises a collection vessel configured to receive harvested tissue and at least one filter element located inside the collection vessel. The apparatus is configured to be received in a centrifuge to separate a Stromal Vascular Fraction (SVF) from the harvested tissue within the collection vessel. At least a portion or extract of the SVF separated from the harvested tissue in the apparatus is used in preparation of a treatment composition comprising a mixture of SVF or extract and a polymer composition for treatment or repair or regeneration of the tissue.
Antibody or binding fragment thereof, fusion protein, or pharmaceutical composition directed against misfolded SOD1 epitope, or nucleic acid encoding the antibody or binding fragment thereof, fusion protein, or pharmaceutical composition, are described. Also provided are methods for using and manufacturing such antibody or binding fragment thereof, fusion protein, nucleic acid, or pharmaceutical composition, as well as methods of their use for treating a disorder in a human subject in need thereof.
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present invention relates to a probe (1; 1a; 1b) for detecting ionizing radiation. The probe (1; 1a; 1b) comprises an elongated flexible support (10) and a detector apparatus (20; 20a; 20b), which is coupled to the flexible support (10) near one end (11) thereof. The flexible support (10) comprises a plurality of electrically conductive tracks (19a-f) coupled to corresponding electrical terminals (24a-f) of the detector apparatus (20; 20a; 20b) to allow the exchange of electrical signals between the apparatus and a processing device (40). Advantageously, the detector apparatus (20; 20a; 20b) comprises a sensor (21) adapted to generate a signal indicative of an intensity of ionizing radiations hitting the detector apparatus (20; 20a; 20b), and a processing module (22) adapted to condition the signal generated by the sensor (21).
Australian Nuclear Science and Technology Organisation (Australia)
University of Wollongong (Australia)
Inventor
Safavi-Naeini, Mitra
Chacon, Andrew Stephen
Abstract
An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.
H05H 13/10 - Accelerators comprising one or more linear accelerating sections and bending magnets or the like to return the charged particles in a trajectory parallel to the first accelerating section, e.g. microtrons
SOUTH EASTERN SYDNEY LOCAL HEALTH DISTRICT (Australia)
THE UNIVERSITY OF WOLLONGONG (Australia)
Inventor
You, Jingjing
Sutton, Gerard
Overmass, Morgan
Lovicu, Frank
Wallace, Gordon
Abstract
The present invention relates to compositions suitable for the delivery of agents to biological targets such as tissues and cells and/or capable of promoting the growth and/or proliferation of cells, and methods for the production thereof. Specifically, a printable collagen bioink comprising type IV collagen is used to produce crosslinked collagen gels comprising mammalian cells, such as endothelial or epithelial cells, for corneal regeneration.
Disclosed herein is a structure comprising: a gate electrode, a dielectric layer, and a planar layer of a topological material being separated from the gate electrode by at least the dielectric layer, and having a contact interface with the dielectric layer to generate an electric field-controlled Rashba spin-orbit interaction on application of an electric field thereto, wherein the topological material exhibits a topological phase transition between a trivial state and a non-trivial state at a critical electric field strength on application of the electric field, wherein the gate electrode is configured to apply the electric field across the planar layer in a direction perpendicular to a plane of the planar layer; and wherein the topological material exhibits a change in bandgap, in the presence of the electric field, having a spin-dependent contribution represented by a proportionality constant αR and a non-spin-dependent contribution represented by a proportionality constant αv; and wherein αR>αv/3.
An electrostimulatable 3-dimensional (3D) electrogel scaffold comprising piezoelectric nanoparticles uniformly dispersed throughout a homogenous hydrogel polymer matrix, wherein the hydrogel polymer matrix is gelled and comprises crosslinked alginate, carboxymethyl-chitosan and agarose polymers.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
An apparatus (1) determines body movement and including a chamber (2) having an internal volume, wherein the chamber is configured to vary in internal volume in response to body movement. The apparatus (1) includes a sensor module (3) configured to detect variances in the internal volume of the chamber (2).
Disclosed herein, in part, are nanometers-thin and uniformly thick polymer films comprising an electrochemically polymerized polymer and a polyelectrolyte. Methods of preparing said nanometers-thin and uniformly thick polymer films are also provided.
C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCompositions of derivatives of such polymers
C09D 165/00 - Coating compositions based on macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCoating compositions based on derivatives of such polymers
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Paper; paper articles of stationery; cardboard; cardboard
packaging; printed matter including newspapers, magazines,
periodicals, journals, pamphlets, books; photographs;
promotional displays being banners of paper, posters and
flags of paper; stationery; instructional and teaching
materials; teaching manuals; teaching materials for
education; educational materials (other than apparatus) for
use in teaching; certificates. Advertising and promotional services, including the
advertising of educational and training courses and research
services; business administration, consultancy and
management services; business research; compilation of
information; services consisting of the compilation of
business and statistical data; business management services;
business management services relating to research and
development, commercialisation of technology, processes and
products and technology transfer; business management and
administration services for the provision of educational
courses and research services; business services relating to
technology transfer; retail services including online retail
services of clothing, books, stationery, bags, computers and
computer accessories; career counselling (employment advice
and information). Academies (education); academy education services; adult
education; advisory services relating to education and
training; arranging of exhibitions for educational and
training purposes; arranging and conducting of workshops
(training); conducting of educational conferences, courses;
conducting of exhibitions for educational and training
purposes; conducting training seminars and workshops;
consultancy services relating to education and training;
design of educational courses, examinations and
qualifications; dissemination of educational material;
education and training information; education and training
services; educational advisory, assessment, examination,
instruction and research services; educational institute
services; educational seminars; health education;
information services relating to education; international
student exchange programmes; library services; management of
education services and events; mentoring (education and
training); organisation of training courses; practical
training (demonstration); providing facilities for
educational purposes; providing information, including
online, about education, training, entertainment, sporting
and cultural activities; provision of educational courses;
provision of facilities for education; provision of
training; provision of training facilities; provision of
education services via an online forum; publication of
educational texts and materials; setting of educational
standards; sports education and training services; training;
vocational guidance (education or training advice);
vocational education and training services; university
education services; sporting and cultural activities and
services; alumni association services being university
services; charitable services, namely education, training
and mentoring. Advisory services relating to scientific, medical,
engineering, social science, metallurgy, mining, building
and technical research; computer and software programming
services; laboratory research; laboratory services
(scientific research or analysis); management of scientific
research projects; medical research including scientific
research for medical purposes and in relation to disease,
gut health, mental health, nutrition and ageing; preparation
of reports and information relating to scientific and
technical research; preparation of statistics for scientific
research; providing information, including online, about
industrial analysis and research services; research and
development (for others); research in all fields of science
and industry, including biology, biotechnology, chemistry,
design, engineering, medicine, molecular sciences, physics,
safety and technology; research services in all fields of
science including marine science and policy; research,
engineering and technical consultancy for industry;
scientific, technical, engineering, technical data and
computer analysis services; social science research
services; social science research services in the fields of
health, environment, sustainability, ageing and early
childhood; research services in the fields of metallurgy and
mining; building research services; building research
services relating to infrastructure, sustainable buildings
and energy storage; clinical trials; design of medical
apparatus; research and development of new products for
others; research relating to computer programming, computer
security and computers; research relating to demographics
for scientific purposes; technological consultancy and
preparation of reports relating to the transfer of technical
(including data, knowledge, protocols, policies and
research) and professional know-how relating to all the
foregoing.
ST VINCENT'S HOSPITAL (MELBOURNE) LIMITED (Australia)
UNIVERSITY OF WOLLONGONG (Australia)
SWINBURNE UNIVERSITY OF TECHNOLOGY (Australia)
THE UNIVERSITY OF MELBOURNE (Australia)
Inventor
Choong, Peter, F.M.
Gambhir, Sanjeev
Wallace, Gordon, George
Duchi, Serena
Onofrillo, Carmine
O’connell, Cathal, D.
Di Bella, Claudia
Moulton, Simon, Edward
Abstract
A functionalised polymer comprising a polymer partially functionalised with: a plurality of photocrosslinkable moieties linked to the polymer, each photocrosslinkable moiety comprising a reactive functionality capable of photocrosslinking; and a plurality of cell adhesion moieties each linked to the polymer via a linker, each cell adhesion moiety comprising a cell adhesion motif, and wherein the functionalised polymer further comprises a plurality of functional groups capable of ionic crosslinking with an ionic crosslinking agent. A method for forming a liquified polymer composition comprising cells from a tissue sample, the method comprising: providing a tissue sample comprising cells; contacting the sample with the functionalised polymer in binding conditions, said binding conditions being conditions that enable binding of cells in the sample to the functionalised polymer, so that said cells are bound to the functionalised polymer; culturing the cells bound to the polymer under conditions and for a time that allows the cell number to increase; providing conditions to induce a solid to liquid phase change of the functionalised polymer; thereby forming a liquified polymer composition comprising cells from a tissue sample.
Disclosed is a method of fabricating an anode for a lithium-ion battery, including milling a mixture of nano-silicon, one or more carbonaceous materials and one or more solvents, wherein the mixture is retained as a wet slurry during milling. The mixture is carbonised to produce a silicon thinly coated with carbon (Si@C) material. Further milling occurs of a second mixture of the Si@C material, one or more graphite, one or more second carbonaceous materials and one or more second solvents, wherein the second mixture is retained as a second wet slurry during milling. The second mixture is carbonised to produce a Si@C/graphite/carbon material. The anode is formed from the Si@C/graphite/carbon material.
Disclosed is an electrochemical cell, system and method for capturing carbon dioxide. In an example the electrochemical mineral carbonation cell comprises a gas permeable cathode and carbon dioxide gas is able to pass into an outer surface of and at least partially through the gas permeable cathode to react with a liquid catholyte. A voltage difference is able to be applied between the gas permeable cathode and an anode. A membrane is positioned between the gas permeable cathode and the anode. The liquid catholyte is positioned between the gas permeable cathode and the membrane and the liquid catholyte includes mineral ions, for example sodium, potassium, lithium or calcium ions, a liquid anolyte is positioned between the anode and the membrane. In operation of the cell, the liquid catholyte flows along an inner surface of the gas permeable cathode, and a carbonate mineral, for example sodium carbonate, potassium carbonate, lithium carbonate or calcium carbonate, is produced at or near the inner surface of the gas permeable cathode and is at least partially transported away from the inner surface of the gas permeable cathode by the liquid catholyte flow.
Board of Regents, The University of Texas System (USA)
University of Wollongong (Australia)
Inventor
Romero-Ortega, Mario I.
Wallace, Gordon G.
Gonzalez-Gonzalez, Maria
Jalili, Rouhollah Ali
Abstract
The present disclosure provides methods of making and applying metalized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
SOUTH EASTERN SYDNEY LOCAL HEALTH DISTRICT (Australia)
THE UNIVERSITY OF WOLLONGONG (Australia)
Inventor
You, Jingjing
Sutton, Gerard
Overmass, Morgan
Lovicu, Frank
Wallace, Gordon
Abstract
The present invention relates to compositions suitable for the delivery of agents to biological targets such as tissues and cells and/or capable of promoting the growth and/or proliferation of cells, and methods for the production thereof. Specifically, a printable collagen bioink comprising type IV collagen is used to produce crosslinked collagen gels comprising mammalian cells, such as endothelial or epithelial cells, for corneal regeneration.
An electrostimulatable 3-dimensional (3D) electrogel scaffold comprising piezoelectric nanoparticles uniformly dispersed throughout a homogenous hydrogel polymer matrix, wherein the hydrogel polymer matrix is gelled and comprises crosslinked alginate, carboxymethyl-chitosan and agarose polymers.
Described is an implantable device and methods for preparing and implanting the device into a subject for use in treating a medical condition when implanted therein. The device comprises at least one coaxial fibre of a hydrophilic polymer and a hydrophobic polymer, wherein at least one of said polymers is loaded with an agent that is active towards treating the medical condition.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
Disclosed is an electro-synthetic or electro-energy cell, and method of operation, comprising a first gas diffusion electrode configured to generate a first gas and be in contact with and adjacent to a first gas body comprising the first gas, and a second gas diffusion electrode configured to generate a second gas and be in contact with and adjacent to a second gas body comprising the second gas. A porous capillary spacer is positioned between the first gas diffusion electrode and the second gas diffusion electrode. The porous capillary spacer is configured to be filled with a liquid electrolyte and to confine the liquid electrolyte in the porous capillary spacer by a capillary effect and whereby the liquid electrolyte has a maximum column height of more than 0.4 cm.
Disclosed is a method of operating an electro-synthetic or electro-energy cell to perform an electrochemical reaction. Also disclosed is an electro-synthetic or electro-energy cell comprising a reservoir containing a liquid electrolyte, a first gas diffusion electrode, and a second electrode. A porous capillary spacer is positioned between the first gas diffusion electrode and the second electrode. Preferably, the porous capillary spacer has an end positioned within the reservoir and in liquid contact with the liquid electrolyte. The method comprises the steps of contacting the first gas diffusion electrode and the second electrode with the liquid electrolyte, and applying or generating a voltage across the first gas diffusion electrode and the second electrode.
Disclosed are zero-gap electrochemical cell architectures that employ molecular-level capillary and/or diffusion and/or osmotic effects to minimize the need for macroscopic external management of the electrochemical cell. Preferably, these effects intrinsically respond to the electrochemical cell conditions, making them self-regulating. In one example is disclosed an electro-synthetic or electro-energy cell, and method of operation, comprising a reservoir for containing a liquid electrolyte, a first gas diffusion electrode positioned outside of the reservoir, and a second electrode positioned outside of the reservoir. A porous capillary spacer is positioned between the first gas diffusion electrode and the second electrode, the porous capillary spacer having an end that extends into the reservoir. Preferably, the porous capillary spacer is able to fill itself with the liquid electrolyte when the end of the porous capillary spacer is in liquid contact with the liquid electrolyte in the reservoir.
Disclosed is an electro-synthetic water electrolysis cell, and method of operation, comprising a first gas diffusion electrode configured to generate a first gas and be in direct contact with a first gas body comprising the first gas, and a second electrode. A porous capillary spacer is configured to be filled with a liquid electrolyte and is positioned between the first gas diffusion electrode and the second electrode. Preferably, an average pore diameter of the porous capillary spacer is more than 2 µm (microns).
A composite thermoelectric material (100) comprising: a host matrix (102) comprising a semiconducting thermoelectric material; and amorphous particles (104) dispersed throughout the host matrix (102), wherein the host matrix (102) includes a polycrystalline structure (106) nucleated by the amorphous particles (104).
H01L 35/16 - Selection of the material for the legs of the junction using inorganic compositions comprising tellurium or selenium or sulfur
H01L 35/18 - Selection of the material for the legs of the junction using inorganic compositions comprising arsenic or antimony or bismuth
H01L 35/22 - Selection of the material for the legs of the junction using inorganic compositions comprising compounds containing boron, carbon, oxygen, or nitrogen
H01L 35/32 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the structure or configuration of the cell or thermocouple forming the device
H01L 35/34 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
ST VINCENT'S HOSPITAL (MELBOURNE) LIMITED (Australia)
Inventor
Choong, Peter F.M.
Francis, Sam Lourdesan
Duchi, Serena
Onofrillo, Carmine
Di Bella, Claudia
Gambhir, Sanjeev
Moulton, Simon Edward
Halkias, Christopher
O'Connell, Cathal D.
Reynolds, Nicholas Paul
Wallace, Gordon George
Abstract
The invention generally relates to cells and compositions comprising same for use in cell therapy, to methods of obtaining same, and to use of same in cell therapy. In one aspect, the invention provides a method for forming a cell composition from a tissue sample, the method comprising: providing a tissue sample comprising cells; contacting the sample with a polymer in binding conditions, said binding conditions being conditions that enable binding of cells in the sample to the polymer, so that said cells are bound to the polymer; culturing the cells bound to the polymer under conditions and for a time that allows the cell number to increase; providing conditions to induce a phase change of the polymer; thereby forming a cell composition from a tissue sample.
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
An implantable device and methods for preparing and implanting said device into a subject for use in treating a medical condition when implanted therein is disclosed. The device comprises at least one composite fibre of a hydrophilic polymer and a hydrophobic polymer, wherein at least one of said polymers is loaded with an agent that is active towards treating the medical condition.
D01F 9/04 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments of alginates
Provided herein are compounds of formula (I) which comprise a cephalosporin antibiotic (present moiety X), bonded to a piperidine diazeniumdiolate (NONOate) or a salt thereof. Also provided are compositions that include a compound described herein and methods for promoting the dispersal of microorganisms from biofilms, inhibiting biofilm formation or development, treating and preventing biofilm-associated diseases and disorders or a Pseudomonas aeruginosa infection in a subject suffering from cystic fibrosis, and killing a biofilm-forming microorganism. (I)
C07D 501/16 - Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/423 - Oxazoles condensed with carbocyclic rings
A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
A61K 31/431 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems containing further heterocyclic ring systems, e.g. ticarcillin, azlocillin, oxacillin
A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
An anti-cancer agent is provided comprising a tumour homing peptide having, or having been modified to present, two cysteine residues, with an arsenic atom between, such that the tumour homing peptide cyclises to give an arsenic-containing anti-cancer agent. This allows for selection of an appropriate tumour homing peptide for treatment of a given cancer whereby the subsequent agent provides for a more targeted delivery of arsenic to the tumour microenvironment.
Australian Nuclear Science and Technology Organisation (Australia)
University of Wollongong (Australia)
Inventor
Safavi-Naeini, Mitra
Chacon, Andrew Stephen
Abstract
An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.
H05H 13/10 - Accelerators comprising one or more linear accelerating sections and bending magnets or the like to return the charged particles in a trajectory parallel to the first accelerating section, e.g. microtrons
G21K 5/04 - Irradiation devices with beam-forming means
30.
METHODS OF MAKING AND BIOELECTRONIC APPLICATIONS OF METALIZED GRAPHENE FIBERS
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
UNIVERSITY OF WOLLONGONG (Australia)
Inventor
Romero-Ortega, Mario
Wallace, Gordon
Gonzalez Gonzalez, Maria
Jalili, Rouhollah Ali
Abstract
The present disclosure provides methods of making and applying metalized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
Board of Regents, The University of Texas System (USA)
Inventor
Romero-Ortega, Mario
Wallace, Gordon
Gonzalez Gonzalez, Maria
Jalili, Rouhollah Ali
Abstract
The present disclosure provides methods of making and applying metallized graphene fibers in bioelectronics applications. For example, platinized graphene fibers may be used as an implantable conductive suture for neural and neuro-muscular interfaces in chronic applications. In some embodiments, an implantable electrode includes a multi-layer graphene-fiber core, an insulative coating surrounding the multi-layer graphene-fiber core, and a metal layer disposed between the multi-layer graphene-fiber core and the insulative coating.
The present disclosure provides a dispersible graphene platelet and a method of making same. The structure of the graphene platelet 10 comprises a base layer 1 of graphene on which at least one discontinuous layer 2, 3, 4 of graphene is stacked, with each layer of graphene above the base layer having a smaller surface area than the layer it is stacked upon. The edges of the base layer and the discontinuous layers stacked upon it are all at least partially functionalised 5, providing a structure with graphene-like properties owing to the base layer and relatively high dispersibility owing to the increased amount of functionalised groups on each platelet. The platelets may be used for a number of applications, for example in the production of electrodes or composite materials.
An implantable device and methods for preparing and implanting said device into a subject for use in treating a medical condition when implanted therein is disclosed. The device comprises at least one coaxial fibre of a hydrophilic polymer and a hydrophobic polymer, wherein at least one of said polymers is loaded with an agent that is active towards treating the medical condition.
A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
Disclosed herein is a composite material comprising a graphene-based material, manganese oxide, and group II metal ions. The graphene based material may be functionalised with an organic moiety comprising an acidic functional group. The composite material may function as a catalyst for electrolysis of water.
An anti-cancer agent is provided comprising a tumour homing peptide having, or having been modified to present, two cysteine residues, with an arsenic atom between, such that the tumour homing peptide cyclises to give an arsenic- containing anti-cancer agent. This allows for selection of an appropriate tumour homing peptide for treatment of a given cancer whereby the subsequent agent provides for a more targeted delivery of arsenic to the tumour microenvironment.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A device and a method for using a device to receive and/or deliver a substance in vivo is disclosed. The device includes a hollow body having a wall that defines an internal volume, wherein the wall comprises at least one opening extending substantially therethrough to facilitate access to the internal volume, and at least one stimuli- responsive membrane mounted to and substantially around an internal surface of the wall to define at least one chamber that is in fluid communication with the at least one opening and is configured to receive and/or deliver a substance via the at least one opening when an external stimulus is applied in proximity to the at least one stimuli-responsive membrane.
A device and method for immobilising a robotic capsule within a body lumen is disclosed. The device comprises a magnetic actuator, and at least one retractable member operably coupled to the magnetic actuator, wherein the magnetic actuator is responsive to an external magnetic field to cause the at least one retractable member to move between a retracted position, in which the at least one retractable member is substantially disengaged from an intraluminal wall of a body lumen, and a deployed position, in which the at least one retractable member is substantially engaged with the intraluminal wall of the body lumen to immobilise the device, and a robotic capsule coupled thereto, at a site specific location therewithin.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION (Australia)
UNIVERSITY OF WOLLONGONG (Australia)
Inventor
Safavi-Naeini, Mitra
Chacon, Andrew Stephen
Abstract
An irradiation method and system for irradiating a target volume, the method comprising: providing thermal neutron absorbing nuclides (such as in the form of a high neutron cross-section agent) at the target volume; and producing neutrons by irradiating nuclei in or adjacent to the target volume with a beam of particles consisting of any one or more of protons, deuterons, tritons and heavy ions, thereby prompting production of the neutrons through non-elastic collisions between the atoms in the path of the beam (including the target) and the particles. The neutron absorbing nuclides absorb neutrons produced in the non-elastic collisions, thereby producing capture products or fragments that irradiate the target volume.
A61N 5/01 - Devices for producing movement of radiation source during therapy
G21G 1/04 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators
39.
DOSIMETRY MONITORING AND MOTION TRACKING OF A GUIDED RADIATION THERAPY SYSTEM
Disclosed is a system for monitoring dosimetry and motion tracking of a guided radiation therapy system. The system includes a phantom configured to be sensed by a tracking system associated with the guided radiation therapy system; and a manipulator to which the phantom is mounted, and which is configured to move the phantom along at least 3 axes and about at least 1 axis. A radiation detector may also be associated with the phantom to sense radiation received from the guided radiation therapy system. A method for dosimetry and motion tracking is also disclosed.
A method of constructing a railway track comprises preparing existing ground so as to receive a layer thereat. Barrier material is laid over the prepared ground. A plurality of tyres that have a single sidewall removed therefrom are placed in a laid-5 flat arrangement such that a remaining sidewall of each resultant tyre cell lies over and adjacent to the barrier material. The tyre cells are in-filled with a fill material. Railway sleepers are arranged in relation to the in-filled layer of tyre cells. Railway tracks are then laid on the railway sleepers.
The present invention broadly relates to 6-substituted derivatives of hexamethylene amiloride, the preparation thereof, and their use in the treatment of diseases such as cancer.
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
Board of Trustees of Northern Illinois University (USA)
Fermi Research Alliance, LLC (USA)
University of Wollongong (Australia)
Inventor
Karonis, Nicholas
Coutrakon, George
Duffin, Kirk
Erdelyi, Bela
Naglich, Kevin
Penfold, Scott
Rubinov, Paul
Rykalin, Victor
Zutshi, Vishnu
Abstract
A proton computed tomography (pCT) detector system, including two tracking detectors in sequence on a first side of an object to be imaged, two tracking detectors in sequence on an opposite side of the object to be imaged, a calorimeter, and a computer cluster, wherein the tracking detectors include plastic scintillation fibers. All fibers in the detector system are read out by Silicon Photomultipliers (SiPM). A method of imaging an object by emitting protons from a source through two tracking detectors, through and around the object, and through two opposite tracking detectors, detecting energy of the protons with a calorimeter, and imaging the object.
G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
G01T 1/20 - Measuring radiation intensity with scintillation detectors
A wind energy conversion apparatus including: a support frame; an upper pair of axially spaced rotating members located in an upper portion of the support frame; a lower pair of axially spaced rotating members located in a lower portion of the support frame, the upper and lower pair of axially spaced rotating members being in general vertical alignment; two endless support means, each mounted around the vertically aligned upper and lower rotating members and configured to move in a circulating motion whereby movement of the endless support means rotates the upper and lower rotating members; and, a plurality of aerofoils coupled between the two endless support means wherein each aerofoil is coupled between the two endless supports at opposed ends of the aerofoil at a position equal to, or forward of, the centre of mass of the aerofoil, wherein wind travelling past the plurality of aerofoils produces a translational force upon the aerofoil which in turn causes movement of the two endless support means and thereby rotation of the upper and lower rotating members.
Methods and systems for performing mass spectrometry are provided herein. The method includes ionizing one or more compounds to generate ions, passing the ions into an ion mobility spectrometer, providing ozone, reacting the ions with ozone to produce ozone-induced fragment ions, and performing mass analysis and detection of the ozone-induced fragment ions. The system can comprise an ion source for ionizing one or more compounds to generate ions, an ion mobility spectrometer for receiving and separating the ions, an ozone supply for introducing ozone into the system; a reaction region for reacting the ions with the ozone to produce ozone- induced fragment ions, and a mass spectrometer for performing mass analysis and detection of the ozone-induced fragment ions.
An electrode for a water splitting device, the electrode comprising a gas permeable material, a second material, for example a further gas permeable material, a spacer layer positioned between the gas permeable material and the second material, the spacer layer providing a gas collection layer and a conducting layer. The conducting layer can be provided adjacent to or at least partially within the gas permeable material. The gas collection layer is able to transport gas internally in the electrode. The gas permeable materials can be gas permeable membranes. Also disclosed are electrochemical cells using such an electrode as the cathode and/or anode, and methods for bringing about gas-to- liquid or liquid-to-gas transformations, for example for producing hydrogen.
The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass- to-charge ratios of the intact analyte ions and the fragments produced by such collision- induced dissociation. The methods and apparatus selectively subject analyte ions to ozone- induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone- induced dissociation.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 49/26 - Mass spectrometers or separator tubes
47.
REDUCED GRAPHENE OXIDE AND METHOD OF PRODUCING SAME
There is provided a method of producing reduced (rGO) or partially reduced (prGO) Graphene Oxide films that have improved conductivity. The method is capable of creating highly conducting (-2000 S/cm), flexible, printable, processable reduced graphene oxide materials without the need for harsh chemical treatment or high temperature annealing. In one embodiment, an electrical circuit consisting of reduced graphene oxide tracks may be patterned into a graphene oxide film by printing with a reducing agent, preferably ascorbic acid.
H01B 1/04 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of carbon-silicon compounds, carbon, or silicon
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
48.
LIQUID ASSISTED GRINDING METHOD FOR PRODUCING IMPROVED BATTERY MATERIAL
A lithium based composite material and method of preparation. Including grinding a mixture of a lithium salt, a metal oxide or salt, a phosphate salt and a carbon source in the presence of a liquid to produce a slurry. The liquid helps the grinding and homogeneous mixing and is not consumed as a reagent. Upon removing the liquid the slurry becomes a dried mixture, and after heating the dried mixture becomes a composite, which can be used as a cathode material in a lithium-ion battery. For example, the composite is LiFePO4-Fe2P-C and shows a specific capacity of 167 mAh/g at 0.2C and 146 mAh/g at 5C after 100 cycles, respectively. At high current density the example composite exhibits long-term cycling stability, retaining around 96% of its original discharge capacity beyond 1000 cycles, which can meet requirements of a lithium-ion battery for large-scale power applications.
There is provided a spray pyrolysis method for producing a graphene oxide based composite. The method includes spraying graphene oxide in suspension or solution into a reaction chamber. Simultaneously or separately spraying at least one precursor in suspension or solution into the reaction chamber. Heating the reaction chamber to produce an in situ chemical reaction between the graphene oxide and the at least one precursor, and retrieving a graphene oxide based composite from the reaction chamber. GO-Mn2O3/Mn3O4 composites were synthesized using the spray pyrolysis method. The results show unique morphology, afforded by the modified spray solution used including a hydroxide suspension, and enhanced capacitance. An exceptionally high capacitance value of about 606 Fg-1 at 5 mVs-1 was observed for an example 20% GO-Mn2O3/Mn3O4 material.
Regulation of nitric oxide release and biofilm development Abstract The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.
C07D 501/24 - 7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
C07D 501/20 - 7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
C07D 503/14 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivativesSuch ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 unsubstituted in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, attached in position 3
A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
In one form, a photoelectrochemical cell comprising a p-type sensitized photocathode including a sensitizer dye and a water-based electrolyte. In another form, the sensitizer dye and an adjacent semiconductor may have a reduction potential that is sufficiently high to either reduce a desired chemical feedstock in the cell or reduce protons in the water to hydrogen gas. The semiconductor to which the sensitizer dye is affixed may be nickel oxide. The photoelectrochemical cell can include a sensitized photocathode and an electrolyte that contains an electron acceptor, where light illumination of the sensitized photocathode results in reduction of the electron acceptor. The electrolyte can include water.
A light-modulating electrical device is disclosed and a method for manufacturing a light-modulating electrical device. The method includes, as a single lamination process, positioning a light-modulating electrical unit at least partially within a recess, the recess provided in a first polymer film or an optically transparent polymer film, and fixing the optically transparent polymer film to the first polymer film so as to cover the light-modulating electrical unit. In one example, the light-modulating electrical unit is comprised of two or more sub-units and is itself formed as part of the lamination process.
B32B 27/06 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance
B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
G02F 1/161 - GasketsSpacersSealing of cellsFilling or closing of cells
Water-splitting devices and methods for manufacturing water-splitting devices or solar cells is disclosed. The method seeks to provide a relatively high-volume, low-cost mass-production method. In one example, the method facilitates simultaneous co-assembly of one or more sub-units and two or more polymer films or sheets to form a water-splitting device. According to another aspect, there is provided an improved water-splitting device. In one example form, there is provided a water-splitting device which includes a first electrode for producing oxygen gas and a second electrode for producing hydrogen gas from water. The first electrode and the second electrode are positioned between a first outer polymer layer and a second outer polymer layer, and at least one spacer layer is positioned between the first outer polymer layer and the second outer polymer layer.
C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
H01L 31/042 - PV modules or arrays of single PV cells
A radiation detector is disclosed that comprises a scintillator that emits electromagnetic radiation in response to excitation by radiation of interest, and a photodetector with a semiconductor active layer adapted to interact with the electromagnetic radiation and a substrate. Either the scintillator constitutes the substrate or the substrate is located such that the substrate is between said active layer and the scintillator, and the substrate is at least partially transparent to the electromagnetic radiation.
A proton computed tomography (pCT) detector system, including two tracking detectors in sequence on a first side of an object to be imaged, two tracking detectors in sequence on an opposite side of the object to be imaged, a calorimeter, and a computer cluster, wherein the tracking detectors include plastic scintillation fibers. All fibers in the detector system are read out by Silicon Photomultipliers (SiPM). A method of imaging an object by emitting protons from a source through two tracking detectors, through and around the object, and through two opposite tracking detectors, detecting energy of the protons with a calorimeter, and imaging the object.
Disclosed are systems, devices and methodologies relating to proton computed tomography. In some implementations, detection of protons can yield track information before and after an object for each proton so as to allow determination of a likely path of each proton within the object. Further, measurement of energy loss experienced by each proton allows determination that a given likely path results in a given energy loss. A collection of such data allows characterization of the object. In the context of energy loss, such a characterization can include an image map of relative stopping power of the object. Various reconstruction methodologies for obtaining such an image, including but not limited to superiorization of a merit function such as total variation, are disclosed. In some implementations, various forms of total variation superiorization methodology can yield excellent results while being computationally efficient and with reduced computing time.
The present invention relates to a two-part curable composition, methods for preparing the two-part curable composition and its use as a polymeric material for lining and reinforcement. The two-part curable composition comprises a first part which is a prepolymer composition comprising an unsaturated polyester, a vinyl-functional monomer and an accelerator; and a second part which is a promoter composition comprising a promoter and a vinyl-functional monomer. In use, the promoter composition of the second part promotes curing of the curable composition when the first and second parts are combined.
A probe (14; 14'), comprising an ultrasonic probe (56a, 56b; 74a, 74b) and a pixellated radiation detector (16) with discrete detecting elements (50a, 50b, 50c) for detecting a predefined radiation. The probe (14) is adapted to be located at least partially within a body cavity. Also, an imaging method, comprising employing such a probe (14) to form an image while located within a body cavity, and a dosimetry method, comprising employing such a probe (14) to conduct dosimetry while located within a body cavity.
A method of providing cognitive training to a user, the method including, in a processing system, presenting a cognitive task to a user, the cognitive task requiring the user to view presented information and provide at least one input response; determining the at least one input response using an input device; determining from a measuring device a measure of electrical activity in the user's brain whilst performing the cognitive task; and, determining a score based on at least one of the at least one input response and the measured electrical activity.
An encapsulation and compression sports bra (1) with cups (7) formed of elastic material to elevate and compress breasts (8) of a wearer (2) to restrict anatomical breast support structures reaching their end of range during downward breast trajectory to thereby reduce exercise induced breast discomfort.
A42C 3/00 - Appliances for hat-making not provided for in group , e.g. for making wire forms for hat-framesApparatus for changing the form or size of finished hats
A dye composition for use in a photoelectric material, the dye composition comprising a plurality of dyes comprising a chromophore and at least one binding group for binding with a semiconductor (preferably a metal oxide semiconductor) wherein the plurality of dyes include a first dye wherein the binding group is linked to the dye chromophore by a linker not in conjugation with the chromophore and a second dye wherein the binding group is attached by a linker in conjugation with the chromophore.
A microdosimeter, comprising an array of three-dimensional p-n junction semiconductor detectors, each providing a sensitive volume-target and a tissue equivalent medium for generating secondary charged particles. The array is manufactured from a semiconductor on insulator wafer and the detectors are located to detect secondary charged particles generated in the tissue equivalent medium.
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Paper, cardboard and goods made from these materials, not
included in other classes; printed matter including
newspapers, magazines, periodicals, journals, pamphlets,
books; photographs; promotional displays being banners of
paper, posters and flags of paper; stationery; instructional
and teaching materials; teaching manuals; teaching materials
for education; educational materials (other than apparatus)
for use in teaching. Advertising and promotional services, including the
advertising of educational and training courses and research
services; business administration, consultancy and
management services; business research; compilation of
information; analysis of market research data. Academies (education); academy education services; adult
education; advisory services relating to education and
training; arranging of exhibitions for educational and
training purposes; arranging and conducting of workshops
(training); conducting of educational conferences, courses;
conducting of exhibitions for educational and training
purposes; conducting training seminars and workshops;
consultancy services relating to education and training;
development of educational courses, examinations and
qualifications; dissemination of educational material;
education and training information; education and training
services; educational advisory, assessment, examination,
instruction and research services; educational institute
services; educational seminars; health education;
information services relating to education; international
student exchange programmes; library services; management of
education services and events; mentoring (education and
training); organisation of training courses; practical
training (demonstration); providing facilities for
educational purposes; providing information, including
online, about education, training, entertainment, sporting
and cultural activities; provision of educational courses;
provision of facilities for education; provision of
training; provision of training facilities; provision of
education services via an online forum; publication of
educational texts and materials; setting of educational
standards; sports education and training services; training;
vocational guidance (education or training advice);
vocational education and training services; university
education services. Advisory services relating to research; computer and
software programming services; laboratory research;
laboratory services (scientific research or analysis);
management of scientific research projects; medical research
including scientific research for medical purposes;
preparation of reports and information relating to
scientific and technical research; preparation of statistics
for scientific research; providing information, including
online, about industrial analysis and research services;
research and development (for others); research in all
fields of science and industry, including biology,
biotechnology, design, engineering, medicine, safety and
technology; research services; research, engineering and
technical consultancy for industry; scientific, technical,
engineering, technical data and computer analysis services;
social science research services.
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Paper, cardboard and goods made from these materials, not
included in other classes; printed matter including
newspapers, magazines, periodicals, journals, pamphlets,
books; photographs; promotional displays being banners of
paper, posters and flags of paper; stationery; instructional
and teaching materials; teaching manuals; teaching materials
for education; educational materials (other than apparatus)
for use in teaching. Advertising and promotional services, including the
advertising of educational and training courses and research
services; business administration, consultancy and
management services; business research; compilation of
information; analysis of market research data. Academies (education); academy education services; adult
education; advisory services relating to education and
training; arranging of exhibitions for educational and
training purposes; arranging and conducting of workshops
(training); conducting of educational conferences, courses;
conducting of exhibitions for educational and training
purposes; conducting training seminars and workshops;
consultancy services relating to education and training;
development of educational courses, examinations and
qualifications; dissemination of educational material;
education and training information; education and training
services; educational advisory, assessment, examination,
instruction and research services; educational institute
services; educational seminars; health education;
information services relating to education; international
student exchange programmes; library services; management of
education services and events; mentoring (education and
training); organisation of training courses; practical
training (demonstration); providing facilities for
educational purposes; providing information, including
online, about education, training, entertainment, sporting
and cultural activities; provision of educational courses;
provision of facilities for education; provision of
training; provision of training facilities; provision of
education services via an online forum; publication of
educational texts and materials; setting of educational
standards; sports education and training services; training;
vocational guidance (education or training advice);
vocational education and training services; university
education services. Advisory services relating to research; computer and
software programming services; laboratory research;
laboratory services (scientific research or analysis);
management of scientific research projects; medical research
including scientific research for medical purposes;
preparation of reports and information relating to
scientific and technical research; preparation of statistics
for scientific research; providing information, including
online, about industrial analysis and research services;
research and development (for others); research in all
fields of science and industry, including biology,
biotechnology, design, engineering, medicine, safety and
technology; research services; research, engineering and
technical consultancy for industry; scientific, technical,
engineering, technical data and computer analysis services;
social science research services.
16 - Paper, cardboard and goods made from these materials
35 - Advertising and business services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Paper, cardboard and goods made from these materials, not
included in other classes; printed matter including
newspapers, magazines, periodicals, journals, pamphlets,
books; photographs; promotional displays being banners of
paper, posters and flags of paper; stationery; instructional
and teaching materials; teaching manuals; teaching materials
for education; educational materials (other than apparatus)
for use in teaching. Advertising and promotional services, including the
advertising of educational and training courses and research
services; business administration, consultancy and
management services; business research; compilation of
information; analysis of market research data. Academies (education); academy education services; adult
education; advisory services relating to education and
training; arranging of exhibitions for educational and
training purposes; arranging and conducting of workshops
(training); conducting of educational conferences, courses;
conducting of exhibitions for educational and training
purposes; conducting training seminars and workshops;
consultancy services relating to education and training;
development of educational courses, examinations and
qualifications; dissemination of educational material;
education and training information; education and training
services; educational advisory, assessment, examination,
instruction and research services; educational institute
services; educational seminars; health education;
information services relating to education; international
student exchange programmes; library services; management of
education services and events; mentoring (education and
training); organisation of training courses; practical
training (demonstration); providing facilities for
educational purposes; providing information, including
online, about education, training, entertainment, sporting
and cultural activities; provision of educational courses;
provision of facilities for education; provision of
training; provision of training facilities; provision of
education services via an online forum; publication of
educational texts and materials; setting of educational
standards; sports education and training services; training;
vocational guidance (education or training advice);
vocational education and training services; university
education services. Advisory services relating to research; computer and
software programming services; laboratory research;
laboratory services (scientific research or analysis);
management of scientific research projects; medical research
including scientific research for medical purposes;
preparation of reports and information relating to
scientific and technical research; preparation of statistics
for scientific research; providing information, including
online, about industrial analysis and research services;
research and development (for others); research in all
fields of science and industry, including biology,
biotechnology, design, engineering, medicine, safety and
technology; research services; research, engineering and
technical consultancy for industry; scientific, technical,
engineering, technical data and computer analysis services;
social science research services.
The present invention relates to a prepolymer composition comprising a polyester prepolymer, a vinyl-functional monomer having a vapour pressure which is less than styrene at 20° C and an accelerator. The prepolymer composition can be combined with a promoter which causes the prepolymer composition to cure. The cured composition forms a polymeric material which is capable of reinforcing surfaces, in particular the surfaces of mine tunnels including longwall coal mine roadways.
The present invention provides a process for producing an electroactive substrate. The process includes providing a substrate having an oxidant layer on a surface thereof, exposing the surface containing the oxidant layer to a vapour containing an aryl or heteroaryl monomer that is polymerizable to form an electroactive polymer, and polymerizing the aryl or heteroaryl monomer in the presence of a volatile Lewis base to form a polyaryl or polyheteroaryl electroactive polymer film on the surface of the substrate. The invention also provides electroactive substrates formed by the process.
C08F 134/04 - Homopolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain and having one or more carbon-to-carbon double bonds in a heterocyclic ring in a ring containing sulfur
G02F 1/15 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on an electrochromic effect
The present disclosure provides a new type of gapless semiconductor material having electronic properties that can be characterized by an electronic band structure which comprises valence and conduction band portions VB1 and CB1, respectively, for a first electron spin polarisation, and valence and conducting band portions VB2 and CB2, respectively, for a second electron spin polarisation. The valence band portion VB1 has a first energy level and one of CB1 and CB2 have a second energy level that are positioned so that gapless electronic transitions are possible between VB1 and the one of CB1 and CB2, and wherein the gapless semiconductor material is arranged so that an energy bandgap is defined between VB2 and the other one of CB1 and CB2.
H01L 49/00 - Solid state devices not provided for in groups and and not provided for in any other subclass; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof
H01S 3/14 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range characterised by the material used as the active medium
H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
H01S 3/102 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation
H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
This invention relates to a method of forming a multi-layer bonded product. The method involves forming a distribution of fine particles on one or both surfaces of two bodies to be roll-bonded. The particles are selected to be embeddable in the surfaces by forcing the surfaces together. The method further involves arranging the bodies with the two surfaces facing each other so the particles are located between the two surfaces. The method further involves causing a thickness reduction to the two arranged bodies for bonding the surfaces to each other such that the particles are embedded in one or both surfaces, thereby bonding the bodies together.
B21B 45/00 - Devices for surface treatment of work, specially combined with or arranged in, or specially adapted for use in connection with, metal-rolling mills
B23K 20/02 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating by means of a press
C23C 8/60 - Solid state diffusion of only non-metal elements into metallic material surfacesChemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using solids, e.g. powders, pastes
B21B 47/00 - Auxiliary arrangements, devices or methods in connection with rolling of multi-layer sheets of metal
B23K 20/04 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating by means of a rolling mill
B22F 7/00 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting
B32B 15/00 - Layered products essentially comprising metal
The present invention relates to a process for the preparation of graphene which can be used in the development of graphene paper or films, graphene-based composites and articles for nanoelectronics, nanocomposites, batteries, supercapacitors, hydrogen storage and bioapplications. This process comprises reducing purified exfoliated graphite oxide in the presence of a base.
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
The present invention relates to a method and apparatus for providing additional shielding to a weld site when welding with a consumable self-shielding welding electrode. The method comprises the steps of producing a shroud gas curtain spaced radially outward from the electrode and substantially controlling the axial position of the shroud gas curtain relative to the distal end of the welding electrode during consumption of said electrode during use, wherein the shroud gas curtain comprises a radially outward component of velocity. The present invention also relates to a welding method and apparatus for providing fume extraction in a manual metal arc welding process.
B23K 9/173 - Arc welding or cutting making use of shielding gas and of consumable electrode
B23K 9/29 - Supporting devices adapted for making use of shielding means
B23K 31/02 - Processes relevant to this subclass, specially adapted for particular articles or purposes, but not covered by any single one of main groups relating to soldering or welding
B23K 35/38 - Selection of media, e.g. special atmospheres for surrounding the working area
72.
MULTI-COMPONENT COMPOSITIONS AND METHODS FOR DELIVERY OF ANTI-CANCER AGENTS
The present invention relates to a composition for the treatment or prevention of cancer, the composition comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof; folinic acid, or a pharmaceutically acceptable salt thereof, oxaliplatin and a cyclodextrin or a pharmaceutically acceptable salt or derivative thereof.
Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical compositions and methods of prophylactic and/or therapeutic treatment of a Group A Streptococcus infection.
C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
C07K 4/04 - Peptides having up to 20 amino acids in an undefined or only partially defined sequenceDerivatives thereof from bacteria
C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
74.
IMPROVEMENTS IN MAGNESIUM DIBORIDE SUPERCONDUCTING MATERIALS AND METHODS OF SYNTHESIS
Improved magnesium diboride superconducting materials and methods of synthesis are disclosed. Embodiments of the superconducting material comprise at least two starting materials capable of forming MgB2 and at least one dopant compound comprising silicon, carbon, hydrogen and oxygen. The starting materials and the at least one dopant compound are heated and mixed at an atomic level to produce a silicon-doped MgB2 superconducting material. Examples of the dopant compound include silicone oil, Triacetoxy(methyl)silane (2), 1,7-Dichloro-octamethyltetrasiloxane (2) and Tetramethyl orthosilicate (6).
H01L 39/12 - Devices using superconductivity or hyperconductivity; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details characterised by the material
C04B 35/58 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
The present invention relates to a method of preparing an intrinsically conducting polymer having a polymeric matrix with an ionic dye retained therein, the method comprising chemical oxidative polymerisation of monomers under acidic conditions in the presence of the ionic dye to form the intrinsically conducting polymer. The invention also relates to a method of forming the intrinsically conducting polymer on a surface of a substrate, a composition for preparing the intrinsically conducting polymer, and to a sensing device comprising the intrinsically conducting polymer.
H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
C07D 207/00 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
A method of treating a steel railway wheels to form a required distribution of compressive residual stress in the rim. In general terms the wheel heated and then quenched from the plate towards the rim. The wheel is first heated to form austenite throughout the plate and rim portions. The wheel is then cooled to form bainite/martensite in the plate portion. The wheel is cooled to form bainite/martensite in an inner portion of the rim. The wheel is cooled to form bainite/martensite in an outer portion of the rim.
C21D 9/34 - Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articlesFurnaces therefor for tyresHeat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articlesFurnaces therefor for rims
The present invention relates to apparatus and a method for displaying at least one welding condition. The apparatus comprises: a monitoring unit for monitoring at least one welding parameter, a processor for determining at least one welding condition in real-time in response to said monitored parameter(s), and a display operatively associated with said processor for displaying the so-determined welding condition in real-time. The present invention also relates to a method for automatically controlling low fume and/or minimised arc length welding conditions during welding, and a method for automatically controlling welding to avoid globular mode of metal transfer.
The present invention relates to a method of detecting and/or quantifying a target molecule from a sample obtained from a subject wherein the method comprises: (i) incubating a fusion protein or conjugate comprising a Ter binding polypeptide fused to at least one anti-target molecule or fragment thereof with a partially double-stranded oligonucleotide for a time and under conditions sufficient to bind to said Ter binding polypeptide thereby producing a complex; (ii) incubating said complex in the presence of said sample comprising said target molecule for a time and under conditions sufficient for said anti-target molecule to bind to said target molecule thereby producing a target-bound complex; (iii) incubating said target-bound complex in the presence of at least one immobilised molecule wherein said immobilised molecule has an affinity to said target molecule; (iv) incubating said immobilised molecule for a time and under conditions sufficient to bind to said target molecule thus immobilising said target molecule; and (v) detecting and/or quantifying said target molecule.
A semiconductor radiation sensor (100), comprising a substrate (102), a carrier material (104) mounted to the substrate (102), and a semiconductor detector (106) mounted to the carrier material (104). A radiation sensitive portion of the semiconductor detector (106) is oriented towards the carrier material (104) and generally away from the substrate (102), and the carrier material is adapted to transmit radiation to the radiation sensitive portion of the semiconductor detector (106). A dosimeter comprising the radiation sensor (100) and a method of manufacturing the radiation sensor (100) are also provided.
The present invention relates to compositions comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof, folinic acid, or a pharmaceutically acceptable salt thereof and a cyclodextrin, or a pharmaceutically acceptable salt or derivative thereof. The invention also relates to methods for the treatment of cancer using such compositions.
A flow analysis apparatus is disclosed. The flow analysis apparatus has at least one wicking channel fluidically coupled to an absorbent pump. A wicking valve is fluidically coupled to the wicking channel to provide a fluidic connection to the sample source where opening the wicking valve allows the absorbent pump to cause liquid to flow down the wicking channel toward the absorbent pump. Other similar wicking valves can be added to provide functions such as calibration and reagent addition. A detection unit allows for analysis of the liquid as it flows down the wicking channel.
A radiation detection apparatus and method, the apparatus (100) comprising a first scintillator (112) for interacting with radiation and outputting light in response thereto, a first photodetector (102) adjacent to the first scintillator (112) for receiving and detecting light from the first scintillator (112) and outputting (108) a first output signal in response thereto, a second scintillator (114) located around the first scintillator (112), for interacting with radiation and outputting light in response thereto, and a second photodetector (104) adjacent to the second scintillator (114) for receiving and detecting light from the second scintillator (114) and outputting (110) a second output signal in response thereto.
A microdosimeter, comprising an array of three-dimensional p-n junction semiconductor detectors, each providing a sensitive volume-target and a tissue equivalent medium for generating secondary charged particles. The array is manufactured from a semiconductor on insulator wafer and the detectors are located to detect secondary charged particles generated in the tissue equivalent medium.
The invention relates to compounds comprising a cytotoxic isatin derivative conjugated to a cell targeting moiety via a spacer group. These conjugates allow the cytotoxic isatin derivaties to be targeted to particular cell and tissue types. The invention also relates to novel isatin derivatives, intermediates used in preparing the conjugates and method of using the conjugates.
The present invention relates to nanostructured composites comprising a nanotube network which is at least partially embedded within a carbon layer. The present invention particularly relates to conducting nanostructured composites for use in the fields of energy conversion, energy storage and also the biomedical field. The present invention also relates to a process via CVD of carbon onto a catalyst layer on a substrate.
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
H01G 9/042 - Electrodes characterised by the material
The present invention relates to a torch (1) for welding and a method of extracting fume gas from a welding site (8). The torch (1) comprises a high energy beam (2) adapted to provide heat to a welding site (8), and at least one shroud gas port (17) spaced radially outward from the high energy beam (2) and adapted to impart to an exiting shroud gas (16) a radially outward component of velocity. Fume gas is preferably extracted from a position radially intermediate the high energy beam (2) and the shroud gas curtain (16).
B23K 26/14 - Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beamNozzles therefor
B23K 26/16 - Removal of by-products, e.g. particles or vapours produced during treatment of a workpiece
87.
A SELF-MAINTAINED SENSOR USING A LOW POWER ACTUATOR
A self-maintained chemical sensing system is disclosed. According to the devices and methods of the invention, it is shown that the BCG-based colorimetric sensor could be reproducibly moved between the predefined site to accomplish the self-maintaining and colorimetric measurement. Colorimetric measurements are achieved by analyzing RGB changes using a video camera or by monitoring photocurrent using an LED emitter and LED detector. The calculated energy consumption rate was ~ 0.17 J / cm2 per cycle for a self-maintained and/or autonomous low cost chemical sensor.
G01N 21/13 - Moving of cuvettes or solid samples to or from the investigating station
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
The present invention provides an electrically conducting polymeric nanocomposite comprising a first electrically conducting polymer and a second electrically conducting polymer which acts as a dopant of the first electrically conducting polymer. The present invention also provides a method for preparing the polymeric nanocomposite and its use in optical and electrochemical devices including electrochromic devices. For example, the polymeric nanocomposite may be in the form of a nanodispersion which may be printed using an inkjet printer enabling fabrication of electroactive and electrochromic devices using roll-to-roll processing methods.
C08L 79/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups
C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCompositions of derivatives of such polymers
H01B 1/00 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors
C08L 101/12 - Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
The present invention relates to nanostructured composites, in particular nanotube/ substrate composites for use in the fields of biomedical materials and devices as well as energy conversion and storage, ion transport and liquid and gas separation. The use of such composites as biomaterials are of particular interest.
Superconducting materials and methods of synthesizing the superconducting materials are disclosed. Embodiments of the methods include mixing at least two starting materials capable of forming a MgB2 superconducting material with at least one organic dopant compound, the organic dopant compound comprising carbon, hydrogen and oxygen. The method further includes shaping the mixed materials into a desired shape and heating the mixed materials to produce a carbon-doped MgB2 super-conducting material.
H01L 39/12 - Devices using superconductivity or hyperconductivity; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details characterised by the material
C04B 35/58 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
H01L 39/24 - Processes or apparatus specially adapted for the manufacture or treatment of devices provided for in group or of parts thereof
91.
REINFORCED STRUCTURAL CONCRETE MEMBERS AND METHODS CONCERNING SAME
A method for determining the helical pitch (S) of a helical reinforcement member required to provide a helically reinforced concrete beam with a predetermined displacement ductility (&mgr;d), the method including determining the helical pitch (S) using the relationship wherein the displacement ductility (&mgr;d) of the reinforced concrete beam is inversely proportional to the helical pitch (S) of the reinforcement member.
E04C 3/34 - ColumnsPillarsStruts of concrete or other stone-like material, with or without permanent form elements, with or without internal or external reinforcement, e.g. metal coverings
E04C 5/01 - Reinforcing elements of metal, e.g. with non-structural coatings
E04C 5/06 - Reinforcing elements of metal, e.g. with non-structural coatings of high bending resistance, i.e. of essentially three-dimensional extent, e.g. lattice girders
A content based image retrieval system that extracts images from a database of images by constructing a query set of features and displaying images that have a minimum dissimilarity metric from images in the database. The dissimilarity metric is a weighted summation of distances between features in the query set and features of the images in the database. The method is useful for image searching such as web-based image retrieval and facial recognition.
A sensor comprises a substrate having nanoparticles of a conducting polymer such as polyanaline printed thereon. Also described is a printing composition for printing onto a substrate, the composition comprising nanoparticles of a conducting polymer such as polyanaline.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
The present invention relates to arc welding torch and a method of extracting fume gas from a welding site. The torch comprises a metal electrode and at least one shield gas port adapted to direct a shield gas curtain around the metal electrode and a welding site. At least one shroud gas port is spaced radially outward from the shield gas port and adapted to impart to an exiting shroud gas a radially outward component of velocity. Fume gas is preferably extracted from a position radially intermediate the shield gas curtain and the shroud gas curtain.
B23K 9/173 - Arc welding or cutting making use of shielding gas and of consumable electrode
B23K 35/22 - Rods, electrodes, materials, or media, for use in soldering, welding, or cutting characterised by the composition or nature of the material
B23K 35/368 - Selection of non-metallic compositions of core materials either alone or conjoint with selection of soldering or welding materials
B23K 35/38 - Selection of media, e.g. special atmospheres for surrounding the working area
A self powered sensing device (100) comprising: a first electrode (110) comprising a conducting polymer; a second electrode (120); and an electrolyte (130), the self-powered sensing device configured such that said first and second electrodes (110, 120) and said electrolyte (130) operate as an electrochemical cell following an occurrence of a condition to be sensed and at least the first electrode functions as the sensing indicator.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
The present invention relates to biocompatible composites, in particular biocompatible nanotube composites in the form of a fibre mat and/or film structure, comprising nanotubes and at least one biomolecule. The invention also relates to a process for preparing a biocompatible composite involving (i) forming a dispersing media comprising nanotubes and at least one biomolecule; and either (ii) introducing the dispersing media of step (i) into a coagulating media optionally comprising at least one biomolecule so as to form a continuous fibre; or (iii) filtering the dispersing media of step (i). Alternatively, the process involves (i) forming a dispersing media comprising nanotubes; and (ii) introducing the dispersing media of step (i) into a coagulating media comprising at least one biomolecule so as to form a continuous fibre. The biocompatible composite is useful as a medical device, preferably in a bio-electrode, bio-fuel cell or substrates for electronically stimulated bio-growth.
The present invention provides a method of determining the dose rate of a radiation source including locating three or more detectors in the vicinity of said source, each for providing an output indicative of the amount of radiation received from said source and determining the location of said source from at least some of said detector outputs, wherein as many of said detector outputs is required to provide an acceptably accurate result are used in determining said location whereby the dose of radiation from said source can be determined from said determined location of said source and either a known activity of said source or a measure of the activity of said source determined by said detectors.
