Described herein are benzothiazole-phenyl-sulfonyl-piperidine compounds for activating N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD).
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
2.
HPIV3-NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure relates to methods of using a human parainfluenza virus 3 (HPIV3) neutralizing antibody to prevent and/or treat HPIV infections.
A device may include a flexible outer surface configured to extend over at least a palm, forming a palm side surface comprising (i) a first surface region adjacent to and covering a metacarpophalangeal (MCP) joint of a user's hand, and (ii) a second surface region adjacent to a wrist opening defined by the flexible outer surface. The device may include a constriction region on the palm side surface, the constriction region disposed between the first surface region and the second surface region such that the first and second surface regions are in opposition. The device is movable between a first default configuration and a second configuration. Movement between the first default and second configuration includes the constriction region pulling the opposing first and second surface regions of the palm side surface towards each other to bend and maintain the MCP joint to a desired angle.
A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
4.
HAIR COMB ATTACHMENT FOR FNIRS PROBES TO IMPROVE SNR AND SUBJECT INCLUSIVITY
A hair manipulation mechanism for use with an optrode of a functional near-infrared spectroscopy (fNIRS) system. The hair manipulation mechanism including a body defining a central axis, and a plurality of comb elements. Where each comb element includes at least one leg extending therefrom that is configured to engage the one or more hairs of the entity, and where each comb element of the plurality of comb elements is adjustable between a first position, in which the comb element is spaced a first radial distance from the central axis, and a second, position, in which the comb element is spaced a second radial distance from the central axis greater than the first distance.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in men and women. Uncontrolled proliferation of CRC cells is pivotal in colorectal tumorigenesis and cyclooxygenase-2 (COX-2) is an important regulatory enzyme in this process. Timely diagnosis is the key to life-saving management of CRC, which is under-diagnosed because colorectal aberrant crypt foci, hyper plastic polyps, micro edemas are often missed with conventional colonoscopy. Disclosed herein are imaging agents tagged to nanobodies specific for COX-2 protein that can selectively accumulate and retain in COX-2 expressing cells and colorectal adenomas, resulting in specific and sensitive of early detection, while reducing background and off-target systemic toxicity. The prospect of combining structural and functional imaging readouts obtained with fluorescence-aided colonoscopy measurements would provide powerful diagnostic information for improved management of colorectal carcinogenesis.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes
6.
Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells
University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
Vanderbilt University (USA)
Inventor
Vorp, David A.
Ramaswamy, Aneesh Krishna
Weinbaum, Justin Sol
Blose, Kory James
Chung, Timothy Kwang-Joon
Kickliter, Trevor
Baruch, Yogev
Curci, John A.
Abstract
A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.
A method for generating a magnetic resonance (MR) image in the presence of an interventional device that induces distortions is provided. The method includes using a processor to perform steps that include accessing a distorted MR image of a subject with the interventional device arranged in the subject. The steps also include using the distorted MR image to determine parameters of a set of spatially differentiable functions that describe an estimated position of the interventional device in the subject. The steps further include determining a magnetic susceptibility map based on susceptibility properties of the interventional device and the estimated position of the interventional device. The steps also include generating a simulated MR image by modifying a reference image of the subject based on the magnetic susceptibility map and updating the estimated position using the simulated MR image to generate an updated position of the interventional device in the subject.
G01R 33/28 - Details of apparatus provided for in groups
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
The presently-disclosed subject matter relates to humanized rodent HER2 sequences. Embodiments of the presently-disclosed subject matter include polypeptides and nucleic acids, cells comprising such polypeptides and such nucleic acids, and genetically-modified rodents. Embodiments of the presently-disclosed subject matter include methods for assessing a candidate therapeutic that contains trastuzumab, pertuzumab, derivatives thereof, and/or drug conjugates thereof.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
9.
INERTIA-BASED IMPROVEMENTS TO ROBOTS AND ROBOTIC SYSTEMS
An Inertial Measurement Unit (IMU) is placed on a robot and outputs inertial information such as angular velocity and linear acceleration of the tip to which it is attached. A robot controller implements a recursive estimation algorithm to fuse robot encoder values with IMU data to determine a statistically optimized estimated position of the robot tip.
A knee prosthesis includes a shank link, a thigh link rotatably coupled to the shank link and at least one powered control element configured to apply a torque between the thigh link and the shank link. The shank motion is described by at least a shank angular velocity relative to an inertial reference frame. The knee prosthesis further comprises at least one sensor, and a controller. The controller is configured to: receive sensor measurements from the at least one sensor and determine a present state of a plurality of states including at least a swing state and a stance state; and provide torque control for the at least one powered control element if the present state is a swing state. The knee prosthesis measures the shank angular velocity. The torque control is a function of at least the shank angular velocity.
7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
1
5-methyl-6- (3-pyrrolidin- 1-1-7,8- dihydro-5H-1,6- naphtbyridin- 6-yl)pyridine- 3-carbonitrile
320.2
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/538 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
The United States as Represented by the Department of Veterans Affairs (USA)
Inventor
Woodard, Lauren F.
Bejoy, Julie
Abstract
Disclosed herein are nephron progenitor extracellular vesicles (EVs) that can be used to treat acute kidney injury and methods of using same. For example, disclosed herein is a composition involving nephron progenitor extracellular vesicles (EVs), wherein the EVs are produced by a method that involves: engineering donor cells to express exogenous SNAI2, EYA1, and SIX1, thereby producing induced nephron progenitor (iNP) cells, or obtaining nephron progenitor-like cells from less differentiated cell types including pluripotent stem cells such as induced pluripotent stem cells or embryonic stem cells; culturing the iNP or NPC cells in a culture medium, thereby producing a conditioned medium; and collecting and purifying nephron progenitor EVs from the conditioned medium.
Systems and methods for pharyngeal phenotyping in obstructive sleep apnea are described herein. An example method includes receiving manometry data for a subject; extracting a plurality of features from the manometry data, where the extracted features include one or more of a high-level breath feature, a frequency feature, or a largest negative connected component (LNCC) feature; inputting the extracted features into a trained machine learning model; and predicting, using the trained machine learning model, at least one of a location of pharyngeal collapse for the subject or a degree of pharyngeal collapse for the subject.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
15.
METHOD FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
A method of treating or ameliorating an inflammatory autoimmune response, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
C07C 215/50 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
C07C 217/58 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
A surgical image guidance system, including: a processing circuit including a processor and memory, the memory having instructions stored thereon that, when executed by the processor, cause the processing circuit to: receive, from an optical device, surface data characterizing a surface of a portion of soft tissue; receive, from an intraoperative imaging device, subsurface data characterizing a subsurface of the portion of soft tissue, wherein the subsurface includes a region of interest; measure, based on the surface data, deformation of the surface of the portion of soft tissue; update, based on at least one of (i) the deformation of the surface and (ii) the subsurface data, a model including a representation of the region of interest; and transmit a visual representation of the model to be displayed to a user.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
17.
SMART PROGRAMMABLE BLOOD PUMP FOR CONTROLLING AND AUTOMATING EXTRACORPOREAL LIFE SUPPORT APPLICATIONS
One aspect of the invention provides a blood pump system comprising a blood pump configured to provide a blood flow in an extracorporeal membrane oxygenation (ECMO) circuit for extracorporeal physiological support for a patient; a magnetic coupling member configured to drive the blood pump to operably provide the blood flow; a direct current (DC) motor configured to drive the magnetic coupling member, thereby driving the blood pump; and a controller configured to regulate a motor speed of the DC motor.
A nanotweezer including an anapole nanoantenna having a double nanohole formed through a central region of the anapole nanoantenna, a spacer layer positioned between the anapole nanoantenna and a reflector layer, and a light source configured to illuminate the reflector layer. Upon illumination of the reflector layer by the light source, an optical gradient force is generated at the double nanohole.
H01Q 19/10 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces
H01Q 1/42 - Housings not intimately mechanically associated with radiating elements, e.g. radome
Disclosed herein are block copolymers that can self-assemble into particles, which can be used to crosslink a hydrophilic polymer. An example block copolymer includes a first block that includes pendant groups that can modulate reactive oxygen species responsiveness and drug interactions, a second block that is hydrophilic, and a third block that is hydrophilic and includes a grafted guest-host moiety. Also disclosed are compositions including the block copolymers, and methods of treating diseases.
In one aspect, the disclosure relates to pharmaceutical compositions containing LPAR5 agonists including, but not limited to, compounds and methods for treating diseases and disorders associated with a mutation in Myosin Vb (MYO5B), decreased lysophosphatidic acid receptor 5 (LPAR5) expression, or both using the same. In one embodiment, the disclosed compositions and kits may be particularly useful in treating microvillus inclusion disease (MVID) and the diarrhea and malabsorption associated with the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
A waveguide assembly for delivering focused acoustic energy includes a housing comprising a chamber filled with a medium for propagating acoustic waves. An acoustic transducer is supported the housing and has a surface facing into the chamber. The surface is configured to transmit acoustic waves into the chamber through the medium toward a focus zone. The waveguide assembly also includes structure configured to focus the acoustic waves transmitted from the surface of the acoustic transducer. The waveguide assembly further includes a flexible elongated waveguide having a first end positioned in the chamber opposite the curved surface, and a second end outside the chamber. The waveguide has a tubular configuration with an inner lumen in fluid communication with the chamber via the first end and being filled with the medium. The first end of the waveguide is configured to be positioned in the focus zone so that the focused acoustic waves are propagated through the medium in the inner lumen of the waveguide.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
Disclosed herein are lipophilic oligonucleotide conjugates that can bind to albumin. An example conjugate includes an oligonucleotide; a lipophilic ligand capable of binding albumin; and a linker attaching the oligonucleotide and the lipophilic ligand, the linker including a branching molecule attached to the oligonucleotide, and a hydrophilic spacer attaching the branching molecule and the lipophilic ligand. Also disclosed are compositions including the conjugate and methods of using the conjugate.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A wearable weight distribution device that includes an upper-body interface, a lower-body interface, and at least one retractable load-bearing component comprising a first end connected configured to be detachably connected to the upper-body interface and a second end configured to be detachably connected to the lower-body interface. The retractable load-bearing component is configured to extend and retract. When the retractable load-bearing component is in an extended position, a load path is provided from the upper-body interface, through the retractable load-bearing component, and to the lower-body interface to transmit at least a portion of the load from the upper-body interface to the lower-body interface.
A cation exchange nanoparticulate sulfonated polystyrene solution comprising a polymer, the polymer having at least one benzenesulfonate monomer and at least one Ca2+ calcium ion that is useful in the treatment of cancer.
Disclosed herein is a method for producing training data using a machine learning model trained with noisy annotated training data. The method includes receiving a plurality of anatomical images and corresponding molecular images, wherein each of a plurality of pairs of corresponding anatomical and molecular images captures a respective biological specimen. The method includes receiving at least one annotation on an anatomical image that is informed by its corresponding molecular image, wherein the at least one annotation identifies a functional unit of interest within the anatomical image. The method includes training a machine learning model using said annotated images, wherein the trained machine learning model is configured for multi-class functional unit segmentation.
Some T-cell receptors (TCRs) require many ligands for activation while others need only a few, functioning in analog or digital modes, correspondingly. Digital performance is best but undiscernible using conventional functional avidity or TCR sequence distance metrics. Correlates of optimal biophysical parameters include magnitudes of ERK phosphorylation, CD3 surface loss, and activation marker upregulation. The disclosed findings underscore the requirement to match TCR performance quality with pMHC copy number, as nature does. Given tumor antigen array paucity, engaging superior digital TCRs appears critical for T-cell adoptive cancer therapies and vaccines. Therefore, disclosed herein are methods for detecting digital T cell receptor interactions with presented antigen and selecting a T cell or antigen based on these methods. Also disclosed are adoptive cell transfer methods for treating a subject with digital T cells identified by the disclosed methods. In addition, disclosed are methods for designing RNA vaccines based on the copy number that elicits a digital T cell response.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
C07K 14/74 - Major histocompatibility complex [MHC]
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventor
Embi, Peter J.
Matheny, Michael E.
Davis, Sharon
Novak, Laurie
Sundrani, Sameer
Salwei Engebretsen, Megan Elizabeth
Nelson, Scott David
Abstract
A graphical user interface (GUI) for managing healthcare algorithms, wherein the GUI is configured to: simultaneously display (710), to a user, information associated with a number of models (410), wherein each of the number of models is configured to analyze a health metric of a patient; identify (720), to the user, an abnormal model from the number of models (440), wherein the abnormal model is operating outside a safety threshold (516); receive (730), from the user, input associated with the abnormal model (512); and cause (740) an action to be performed in response to receiving the input from the user.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
Tops as clothing; Tops as clothing for men and women; Athletic tops; Knit tops; T-shirts; Long sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Blouses; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Education, entertainment, sporting and cultural services
Goods & Services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
41 - Education, entertainment, sporting and cultural services
Goods & Services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Cardigans; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors
41 - Education, entertainment, sporting and cultural services
Goods & Services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
Tops as clothing; Tops as clothing for men and women; Athletic tops; T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Hats; Headwear; Caps being headwear; Caps with visors
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeve shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Vests; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Sports bras; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Clothing jackets; Outerwear, namely, jackets; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Uniforms; Athletic uniforms; Clothing, namely, cheerleading uniforms and apparel; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
48.
ACTION OF L-CITRULLINE TO PREVENT OR TREAT ENDOTHELIAL DYSFUNCTION
This invention provides methods for treating endothelial dysfunction by administering an effective amount of citrulline to a patient. The patients may be suffering from acute respiratory distress syndrome (ARDS), sepsis, or infection by COVID-19 (Coronavirus Disease 2019); COVID-19 patients may be at risk of developing endothelial dysfunction, or they may be experiencing endothelial dysfunction. The effective amount of citrulline is sufficient to reduce the uncoupling of endothelial nitric oxide synthase (eNOS) or to reduce the formation of free radicals. Citrulline may be administered orally; intravenously; or both orally and intravenously in a sequential manner. Sequential administration of citrulline may be in three phases, such as (a) an initial phase in which citrulline is administered orally, (b) an intermediate phase wherein citrulline is administered intravenously, and (c) a final phase wherein citrulline is administered orally. The intermediate phase may be while the patient's breathing is being assisted mechanically.
THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventor
Hawiger, Jack Jacek
Zienkiewicz, Jozef
Liu, Yan
Qiao, Huan
Abstract
Disclosed are methods for assessing the responsiveness of a patient to a Nuclear Transport Checkpoint Inhibitor (NTCI) as well as the efficacy of a NTCI treatment regimen. Additionally disclosed herein are methods of genomic diagnosing a subject with an inflammatory skin disease.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A haptic training system for developing skills and training for soft-tissue surgeries. The system includes one or more robotic arm assemblies and a computing device. The robotic arm assembly includes a frame, an upper manipulation linkage assembly coupled to the frame, a lower manipulation linkage assembly coupled to the frame, one or more actuators coupled to the upper manipulation linkage assembly or the lower manipulation linkage assembly, a tool stem assembly coupled to the upper manipulation linkage assembly and the lower manipulation linkage assembly, the tool stem assembly configured to support a surgical tool, and a sensor assembly coupled to the tool stem assembly. The computing device is configured to receive magnetic flux density data from the sensor assembly when a force is applied to the tool stem assembly, determine a position and an orientation of the tool stem assembly based on the magnetic flux density data, estimate forces of interaction with the upper manipulation linkage assembly and the lower manipulation linkage assembly based on electrical current of the one or more actuators, calculate an estimation of force at a distal end of the surgical tool based on the position and the orientation of the tool stem assembly and the forces of interaction, and process the estimation of force at the distal end of the surgical tool to provide real-time haptic feedback to the user via the surgical tool.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
51.
ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Disclosed herein are (6-(4-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, (6-(4-(difluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, and (6-(2-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.
The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Thromboxane A2 receptor antagonists, such as ifetroban, inhibit solid tumor metastasis. The formation of surface and microscopic lung metastases are inhibited. Thromboxane A2 receptor antagonists can inhibit the tumor metastasis process without affecting the growth or development of a primary tumor.
The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
Identifying a fibroblast subtype in a thyroid cancer involves obtaining a fine needle aspiration (FNA) biopsy sample from a subject, the sample including nucleic acids; assaying the nucleic acids in the sample for an increase in the amount of mRNA produced by genes of a fibroblast gene signature relative to a control level of mRNA produced by the genes in a sample obtained from a healthy subject; and identifying the fibroblast subtype if there is an increase in the amount of mRNA in the sample relative to the control level.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
56.
METHODS AND APPARATUS FOR INTRAOPERATIVE ASSESSMENT OF PARATHYROID GLAND VASCULARITY USING LASER SPECKLE CONTRAST IMAGING AND APPLICATIONS OF SAME
One aspect of the invention relates to an apparatus for assessment of parathyroid gland viability comprising a diffuser configured to diffuse a beam of light onto a tissue surface of a parathyroid gland of a patient to illuminate the tissue surface; and means for obtaining speckle contrast images for the assessment of parathyroid gland viability.
In one aspect, the disclosure relates to a dorsal spanning plate assembly comprising a first plate member that can be fixed to a bone or bone fragment distal to a distal radius fracture and a second plate member that can be fixed to a bone or bone fragment proximal to the distal radius fracture. In an aspect, the dorsal spanning plate assembly includes a joint such as, for example, a hinge joint or a ball-and-socket joint, wherein the joint is not fixed during placement of the dorsal spanning plate assembly. In still another aspect, a subject in whom the dorsal spanning plate assembly is implanted retains some range of motion in the fractured joint, thereby reducing muscle atrophy and retaining joint flexion during recovery. Also disclosed are methods of setting bone fractures using the dorsal spanning plate assembly.
Disclosed herein is a custom platform called NSC-seq that can be used for cell lineage and cell division tracking in a temporal fashion but also with single-cell resolution. With simultaneous integration of single-cell transcriptomics with lineage barcoding and temporal recording information, NSC-seq facilitates the generation of multidimensional datasets for elucidating functional heterogeneity and clonal events in vivo. We apply this platform (i) to decipher lineage branching of mouse embryonic development, (ii) to record clonal dynamics of the adult intestinal epithelium, and (iii) to track clonal composition of the mouse intestinal tumors. In addition, we apply NSC-seq to assess a comprehensive gene expression phenotype for individual gene knockout at the single-cell level using existing whole-genome CRISPR knockout screening plasmid libraries. Overall, NSC-seq enables in vivo temporal recording of mammalian development and cancer at single-cell resolution.
Systems and methods are provided for evaluating an adaptive radiotherapy system. An apparatus includes a housing formed from a first material having a first appearance under a selected imaging modality and a target that is inserted into the housing. The target includes a plurality of target components formed from a second material having a second appearance under the selected imaging modality. The plurality of target components are manipulable to assume at least a first configuration comprising a first subset of the plurality of target components and a second configuration comprising a second subset of the plurality of target components that is different from the first subset of the plurality of target components.
Methods and systems for automatic segmentation of structures of interest of an organ in an MR image. The method includes creating a weighted active shape model (wASM); registering model points of the structures in an MR atlas image to a target image that is the MR image to be segmented, as initial model points of the structures in the target image; and iteratively fitting the wASM to the target image, starting from the initial model points, until the shape converges, wherein the final shape is the segmentation of the structures of interest.
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
61.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
62.
ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
Methods and apparatus for generating intraocular overlay patterns in an optical microscope. In one example, an intraocular overlay pattern is generated using a digital micromirror device located in the intermediate focal plane of a telecentric optical relay coupled between the objective lens and an eyepiece of the optical microscope. In some examples, the overlay pattern displays real-time visualization of intraoperative optical coherence tomography data and surgical field overlays. Such overlay patterns can beneficially be used, e.g., to provide real-time intraoperative feedback during ophthalmic surgery substantially without any interference with the surgical workflow.
Methods and apparatus for quantifying an injected volume in an area of tissue during a medical procedure. In one example, a method includes determining a pixel-to-size scale parameter based on a pixelated image of a reference object included in a FOV of an optical instrument configured to perform volumetric imaging, the FOV further including an injection site; computing a first 3D model of the injected volume in the area of tissue based on a volumetric image of the FOV obtained using the optical instrument; refining the first 3D model to obtain a second 3D model of the injected volume, the refining including correcting a shape and a size of the first 3D model to reduce distortions associated with light refraction at a boundary of the injected volume in the area of tissue; and calculating a value of the injected volume based on the second 3D model and further based on the pixel-to-size scale parameter.
G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
Systems, methods, and kits useful for detecting and locating internal bleeding, such as gastrointestinal bleeding, during active or inactive bleeding. In some embodiments, the systems, methods, and kits make use of a single photon emission computed tomography (SPECT) tracer. The kit for preparing a technetium-99m (99mTc)-labeled composition for targeting an injured site in a blood vessel, comprising: -a conjugated human fibrinogen, wherein the human fibrinogen is bonded to a chelating agent selected from the group consisting of diethylene triamine pentaacetate (DTPA) dianhydride.
The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
Disclosed herein are methods for treating or reducing symptoms of preterm labor or decreasing preterm birth in a subject. The methods include administering to the subject a therapeutically effective amount of a compound for tocolytic use.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
70.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
71.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
72.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
C07B 59/00 - Introduction of isotopes of elements into organic compounds
73.
Supermere Nanoparticles and Methods of Isolation and Use Thereof
Disclosed herein is a newly identified secreted nanoparticle that is morphologically and molecularly distinct from the recently described nanoparticle termed an exomere. The disclosed nanoparticle is referred to herein as a supermere. Both exomeres and supermeres are amembranous in contrast to membrane-enclosed extracellular vesicles (EVs). Supermeres are smaller and morphologically distinct from exomeres. These supermeres contain cargo with diagnostic and therapeutic applications.
Disclosed herein are protein-based compositions and conjugates thereof that can take advantage of beneficial delivery properties to improve vaccine efficacy. An example protein-based composition includes an albumin-binding nanobody and a peptide antigen domain. An example conjugate includes the protein-based composition attached to a drug through a linker. Also disclosed are methods of making and using the protein-based compositions and conjugates thereof.
The present invention discloses a method for reducing inflammation in a subject by administering an effective amount of anacardic acid (AA) or a pharmaceutically acceptable salt thereof. Anacardic acid, represented by the chemical structure, has been found to exhibit anti-inflammatory properties when administered to a subject in need thereof. The method provides a novel approach to treating inflammation by utilizing anacardic acid or its pharmaceutically acceptable salt, offering a promising therapeutic option for managing inflammatory conditions in subjects.
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective amount of ifetroban or a pharmaceutically acceptable salt thereof.
A handheld imaging system comprises a light delivery member optically coupled with a light source for delivering light emitted from the light source to tissue of a target region to illuminate the tissue; and an imaging member for detector for collecting the images of optical signals emitted from the tissue responsive to the light illumination. The light delivery member and the imaging member are incorporated into a handpiece.
The disclosed system predicts the biological age of skeletal remains using a convolutional neural network (trained, for example, using 693 radiographs from 136 adults interred in lead coffins in the eighteenth and nineteenth centuries in the crypt of London's St. Bride's Church). Additionally, to increase explainability and minimize the risk of overfitting, the disclosed system uses backpropagation to generate heatmaps that localize relevant regions of the skeletal remains that are class-discriminative (i.e., most important to the model in predicting the age-at-death).
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
80.
SMOOTH MUSCLE CELLS SEEDED IN MICROCHANNELS WITHIN HYDROGELS TO FORM FUNCTIONAL MEDIAL LAYERS IN ENGINEERED MICROVASCULATURE
In one aspect, the disclosure relates to engineered microvessels including a microchannel formed in a hydrogel material; and a medial layer including a plurality of mural cells such as, for example, smooth muscle cells and/or pericytes; wherein each one of the plurality of mural cells is in contact with a wall of the microchannel; and wherein the plurality of mural cells are helically aligned at an angle relative to a lengthwise axis of the microchannel. The microvessels have narrow diameters consistent with resistance microvessels such as small resistance arteries and arterioles and tunable stiffness resulting from degree of crosslinking within the hydrogel material. Also disclosed are methods of making the microvessels, microvessel networks including the microvessels, and engineered organs and tissues including the microvessels. Furthermore, disclosed is a method for inducing vasoconstriction and vasodilation in the microvessels, networks, and engineered organs and tissues.
The second most common CHIP mutation, Ten eleven translocase 2 (TET2), is known to produce worse atherosclerosis in models of atheroprone mice, potentially through an inflammatory mechanism. Disclosed herein is an important modulator in the initiation and progression of atherosclerosis formation in the setting of TET2 inactivation. Macrophage migration inhibitory factor (MIF), a chemokine, was Identified as a highly expressed signaling pathway in single cell analysis of TET2 CHIP patients. In a large population, a MIF single nucleotide variant (SNV) resulting in increased MIF production was correlated with increased coronary disease in the setting of TET2 inactivation. Moreover, MIF inhibition was found to reduce the atherosclerotic burden in atheroprone mice with TET2 inactivation.
A61P 9/00 - Drugs for disorders of the cardiovascular system
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
82.
POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
5,6,7,8-Tetrahydro-1,6-naphthyridines substituted in the 6-position with pyrimido[1,2-b]pyridazin-4-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
5,6,7,8-Tetrahydro-1,6-naphthyridines substituted in the 6-position with pyrimido[1,2-b]pyridazin-4-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
Skin biomolecular profile assessment methods and systems that can analyze the molecular composition of the skin using molecular-level, user-specific data to assess an individual's skin state and/or disease state are described herein. An example method includes receiving skin data associated with a subject, where the skin data includes a biomolecular profile. The method also includes inputting the skin data into a trained artificial intelligence (AI) model and receiving, from the trained AI model, a skin care prediction.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
84.
SIMULTANEOUS DETECTION OF ANTIGENS AND ANTIGEN SPECIFIC ANTIBODIES IN A GUINEA PIG MODEL SYSTEM
Disclosed herein are methods of determining broadly neutralizing antibodies, antigen specific cell sorting and developing vaccine compositions in a guinea pig model system using LIBRA-seq.
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
Disclosed are various approaches for a sensor, having a rotating magnetic spinner disposed at a first end of a shaft and configured to rotate about the shaft. The sensor can include a foot disposed at a second end of the shaft and a plurality of microspikes disposed on a distal surface of the foot.
G01N 11/16 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
A dynamic organ storage system includes an insulating container with a lid enclosing an internal volume. Within the internal volume, an organ container with a lid that houses an organ submerged in perfusate, the lid includes at least one inlet port and at least one outlet port. At least one pressure bag, storing more of the perfusate, is tilted at an angle above the organ container. At least one infusion line enters the organ container via the at least one inlet port and connecting the at least one pressure bag to the organ to gravity flow the perfusate into the organ. A sampling line connected to the organ exits the organ container through the at least one outlet port for a user to monitor a condition of the organ. At least one cooling mechanism maintains the organ at a hypothermic temperature for a time without requiring power.
Disclosed are various approaches for an apparatus having a tubular member which has a radially external side and a radially internal side. The apparatus can further include a plurality of artificial cilia disposed circumferentially on the radially internal side of the tubular member, where the plurality of artificial cilia forming arrays extending longitudinally along the radially internal side of the tubular member.
A61F 2/48 - Operating or control means, e.g. from outside the body, control of sphincters
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
89.
ELECTROCHEMICAL ION PUMPING DEVICES AND METHODS OF USE THEREOF
Disclosed herein are electrochemical ion pumping devices and methods of use thereof. Also disclosed are Ion diffusion across electrode and IBM films. Concentrations of the diluate and brine in experiments with spontaneous ion diffusion across commercial cation exchange membrane (CEM), cation electrode (CE), and conventional electro-sorption electrode without ion exchange polymer filler.
C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
B82Y 40/00 - Manufacture or treatment of nanostructures
90.
GENERATION OF HUMAN ALLERGEN- AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
Described herein are methods, systems and computer program products for individualized, non-invasive brain stimulation for enhanced learning. In some instances, high spatial-resolution and/or high temporal-resolution brain data is predicted based on new low spatial-resolution and/or new low temporal-resolution brain data using trained artificial intelligence (AI).
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
A61B 5/291 - Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
Disclosed herein are conjugates that can effectively deliver nucleic acid agonists to biological environments. An example conjugate includes a block copolymer including a first block that is hydrophilic, a second block that is hydrophobic, and a linking unit that covalently attaches a nucleic acid agonist to the block copolymer. Also disclosed are particles including self-assembled conjugates, methods of treating diseases, and methods of modulating RIG-I activity in a cell.
A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A machine vision system may include a meta-imager including a meta-optic and a polarization-sensitive photodetector. A machine vision system may further include and at least one processor operably coupled to the polarization-sensitive photodetector, and at least one memory operably coupled to the at least one processor. A machine vision system may be configured to: receive, from the polarization-sensitive photodetector, a plurality of feature maps; input, into a trained artificial neural network, the plurality of feature maps; and process, using the trained artificial neural network, the plurality of feature maps to recognize an object.
This disclosure provides methods for treatment comprising co-administering insulin and glucagon to a subject, and co-formulations comprising insulin and glucagon.
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
95.
APPARATUS AND METHODS OF SUBLIMATION FOR REPEATABLE UNIFORM OR PATTERNED DEPOSITION OF MATRIX CRYSTALS ON SOLID SUBSTRATES
This disclosure relates to apparatus and methods for sublimation and deposition of chemicals. In particular aspects, this disclosure relates to apparatus and methods for patterned sublimation and deposition of chemicals for use in matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). In specific aspects, the apparatus comprises a vacuum chamber and a template comprising a planar surface containing the chemical to be sublimed, where the template is located within the vacuum chamber.
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
C07D 263/30 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
An integrated circuit includes a substrate, having a plan view describable along a first axis and a second axis, and a plurality of transistors provided on an area of the substrate. The first axis and the second axis are orthogonal. Each transistor has a distinct active area. The plurality of transistors consists of a plurality of both p-type and n-type transistors. A first transistor is arranged in a first row containing a second transistor, and the active areas of the first transistor and the second transistor are in a similar orientation as the first axis. A third transistor is arranged in a second row and oriented in a same direction as the first axis. A fourth transistor is arranged in a third row distinct from both the first row and the second row. Compared to the third transistor, the fourth transistor is farther from the first and the second transistors.
G06F 30/392 - Floor-planning or layout, e.g. partitioning or placement
H01L 27/02 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier
Disclosed herein are drug coated medical devices that can be used for the treatment of vascular diseases. An example device includes a medical device having an outer surface, and a multi-layer drug coating on the outer surface, the multi-layer drug coating including at least one polycationic layer including a cationic therapeutic and at least one polyanionic layer including an anionic polymer. Also disclosed are methods of making the drug coated medical devices and methods of treating vascular diseases.
A fluidic system includes a systemic circulation and mixing reservoir, at least one flow bus, and at least one pump, fluidically coupled to one another, creating a fluidic network therewith; a delivering means fluidically coupled to the at least one pump; and a plurality of fluidic modules, each fluidic module having an input port fluidically coupled to the delivering means, and an output port fluidically coupled to one of the at least one flow bus. In operation, the at least one pump withdraws media from the systemic circulation and mixing reservoir and delivers the media to the delivering means that in turn delivers the media to the plurality of fluidic modules individually, and then the effluent of the plurality of fluidic modules is delivered to the systemic circulation and mixing reservoir through said one of the at least one flow bus.
