Abstract

The present disclosure described bi-functional delivery particles with the ability to bind to two different cell types in a distinct fashion. Employing a first ligand with differential binding capabilities, the delivery particles may bind to a first target, such as cell, in a reversible fashion such that when they encounter a second target (e.g., cell) a second ligand that bind irreversibly to the second target will disrupt the binding to the first target. As such, the first target acts as a carrier to delivery the particle to a diagnostic or therapeutic second target. In particular aspects, the first and second cells are circulating cells.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 38/19 - CytokinesLymphokinesInterferons
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

Variation in a single nucleotide of a target or template nucleic acid may be significant in many ways. For infectious disease, many drug resistance mutations are known and a simple means to confine their absence would more quickly match a patient with an infection with the most effective treatment. This disclosure provides for a simple, low resource strategy allowing the detection of single nucleotide variation using only low-cost diagnostic methods already available in many locations. A key to this approach is the use of left-handed DNA (L-DNA) as a comparator molecule for D-DNA targets. L-DNA provides numerous additional advantages such as low cost and stability.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

Wearable assistance devices and methods of operating and using the same are provided. A wearable assistance device includes a first body interface and a second body interface. The assistance device also includes one or more elastic members operatively coupling the first body interface to the second body interface and extending along a body segment (e.g., back, elbow, knee, etc.) of the user so as to provide an assistive force to or assistive torque about the body segment or another body segment. The assistance device further includes a clutch mechanism operatively connected to at least one of the one or more elastic members, the clutch mechanism configured to selectively adjust the assistive force or assistive torque provided by the one or more elastic members to/about the body segment or the another body segment.

IPC Classes  ?

• A61F 5/02 - Orthopaedic corsets
• A61B 5/389 - Electromyography [EMG]
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
• F16D 13/58 - Friction clutches Details

Abstract

A condition of a brain can be treated with closed-loop neuromodulation. At least one recording electrode can record conduction data from at least a portion of the brain. At least one stimulating electrode can apply an electrical signal to another portion of the brain. A controller can execute stored instructions and a stored patient-specific model to: receive the conduction data at a time; project the conduction data through the trained patient-specific model to determine a brain state at the time; update at least one parameter of the electrical signal based on a propensity of the brain state at the time to cause an effect of the conduction of the brain; and update the trained patient specific model to include the brain state at the time and an effect of the updated parameter of the electrical signal on the brain state at the time.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

A condition of a brain can be treated with closed-loop neuromodulation. At least one recording electrode can record conduction data from at least a portion of the brain. At least one stimulating electrode can apply an electrical signal to another portion of the brain. A controller can execute stored instructions and a stored patient-specific model to: receive the conduction data at a time; project the conduction data through the trained patient-specific model to determine a brain state at the time; update at least one parameter of the electrical signal based on a propensity of the brain state at the time to cause an effect of the conduction of the brain; and update the trained patient specific model to include the brain state at the time and an effect of the updated parameter of the electrical signal on the brain state at the time.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

An electrohydrodynamic tweezer device and method of separating nano-sized particles in a sample. The electrohydrodynamic tweezer device includes a first electrode, a second electrode including a gold film and an array of microholes formed therein, a fluidic chamber between the first electrode and the second electrode, and a voltage source configured to generate an electric field between the first electrode and the second electrode, wherein the array of microholes results in an array of electrohydrodynamic potentials to trap nanoscale-sized particles on the gold film.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A minimally invasive device, containing a pressure channel, camera, and optical fiber imaging probe, to measure the stiffness of tissues in vivo and ex vivo is disclosed. To measure tissue stiffness in vivo, the device is inserted into a patient and navigated to a tissue of interest, where stiffness is evaluated by applying suction and measuring the elongation or by applying compression force and measuring the compression of the tissue. Biopsies can be taken for further analysis, or tissue can be removed using an ablation laser. Small fluorescent molecules or therapeutics can also be delivered for improved visualization and targeted treatment. As such, this technology may be used to evaluate the stiffness of biomaterials as well as tissues and organs that are difficult to access, allowing for simultaneous diagnosis, treatment, and excision of diseased tissues.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
• A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

A method for assessing tissue perfusion in a living subject comprises identifying a target tissue using autofluorescence detection with a fiber optic probe-based fluorescence detection system; administering a dose of a contrast agent to the living subject, wherein the dose is about 0.6 mg; detecting fluorescence emitted from the contrast agent in the target tissue using the fiber optic probe-based fluorescence detection system, without acquiring an image of the target tissue; quantifying the detected fluorescence to obtain a detection level and/or detection ratio; and determining a degree of perfusion of the target tissue based on the detection level and/or detection ratio.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements

Abstract

An example method of training a large language model for antibody generation includes: receiving a training corpus comprising a plurality of antigen amino acid sequences and a corresponding plurality of antibody sequences, generating a plurality of training strings, where each training string comprises an antigen sequence and a corresponding antibody sequence, fine-tuning a pretrained protein language model by autoregressively training on the plurality of training strings, and outputting a fine-tuned protein language model configured to output human antibodies in response to receiving an input string comprising an antigen.

IPC Classes  ?

• G16B 35/20 - Screening of libraries
• G16B 40/20 - Supervised data analysis
• G16B 40/30 - Unsupervised data analysis
• G16B 5/20 - Probabilistic models
• G06N 3/042 - Knowledge-based neural networksLogical representations of neural networks

Abstract

The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

IPC Classes  ?

• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Abstract

Methods of inhibiting acrolein activity in a subject in need thereof, comprising administering acrolein scavenging compounds.

IPC Classes  ?

• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure provides include kits, compositions, and methods related to impaired respiratory health (e.g., diseases and conditions relating to lung injury). In particular, the present disclosure provides include kits, compositions, and methods for quantifying biomarkers (e.g., proteins, nucleic acids, etc.) associated with an accelerated decline in rapid forced expiratory volume in 1 s (FEV1) and assessing the risk of, monitoring, treating and/or preventing respiratory diseases and conditions.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A system and method for determining a single event breakdown voltage for a wide bandgap semiconductor power device. The power device includes an epitaxial layer composed of a wide bandgap semiconductor material such as SiC having a critical energy density. A specific doping level is applied to the epitaxial layer based on a relationship between doping level and the critical energy density to produce a power device with a specific single event breakdown voltage.

IPC Classes  ?

• H10D 62/10 - Shapes, relative sizes or dispositions of the regions of the semiconductor bodiesShapes of the semiconductor bodies
• H10D 62/60 - Impurity distributions or concentrations
• H10D 62/832 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge being Group IV materials comprising two or more elements, e.g. SiGe
• H10D 62/85 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs

Abstract

Disclosed herein are methods for stimulating liver cell proliferation or liver regeneration in a subject. The methods include administering to the subject a therapeutically effective amount of a compound for activating a tropomyosin kinase receptor (TRK).

IPC Classes  ?

• C07K 14/48 - Nerve growth factor [NGF]
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

A system for generative artificial intelligence based adaptive training. The system includes an electronic processor. The electronic processor is configured to receive a prompt to generate a virtual training assistant, the prompt including a description of one or more training aids and a format for responses corresponding to the one or more training aids. The electronic processor is also configured to retrieve, using a retrieval model, personnel information from a personnel database, retrieve, using the retrieval model, knowledge information corresponding to the personnel information from a knowledge database, and augment the prompt to include a compliance rule regulating responses of the virtual training assistant. The electronic processor is also configured to generate, using a generator model, the virtual training assistant based on the prompt and configured to generate responses corresponding to the personnel information, the knowledge information, the responses being in compliance with the compliance rule.

IPC Classes  ?

• G06N 3/0475 - Generative networks
• G06N 5/02 - Knowledge representationSymbolic representation

Abstract

As disclosed herein, overexpressing NOP2/Sun RNA Methyltransferase 2 (NSUN2) in 293T cells (NSUN2-293T) resulted in a statistically significant increase in lentivirus titers and protein production (compared to parental 293T cells). Therefore, disclosed herein is a method of enhancing protein production and secretion, XXX, and viral production in a cell that involves overexpressing a NSUN2 gene in the cell to enhance protein production and secretion, XXX, and/or virus production and transduction.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12P 21/00 - Preparation of peptides or proteins
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 7/02 - Recovery or purification
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Abstract

The present disclosure relates to methods for simultaneous detection of antigens and antibodies or host receptor proteins that specifically bind said antigens.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6869 - Methods for sequencing

Abstract

Disclosed herein are Tamm polariton emitters and methods of making and use thereof. The Tamm polariton emitters disclosed herein comprise: a distributed Bragg reflector; and a layer comprising a conductive and/or polaritonic material; wherein the distributed Bragg reflector is disposed on the layer of the conductive and/or polaritonic material. The Tamm polariton emitters can further include a layer of a polar material. Also disclosed herein are non-dispersive infrared sensors comprising: any of the Tamm polariton emitters disclosed herein, wherein the Tamm polariton emitter is configured to selectively emit radiation at a frequency corresponding to a rotational or vibrational resonance frequency of an analyte of interest; and a detector configured to receive an electromagnetic signal from the Tamm polariton emitter and/or the analyte of interest. Also disclosed herein are methods for designing Tamm polariton emitters. The methods can, for example, comprise an inverse design protocol and/or machine learning.

IPC Classes  ?

• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis

Abstract

HHc111), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 25/22 - Anxiolytics
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings

Abstract

fH111), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.

IPC Classes  ?

• C07D 267/14 - Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 25/00 - Drugs for disorders of the nervous system
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine

Abstract

Systems and methods for gradient profile generation and automated cell cytometry analysis are disclosed. The technology comprises a computer controller, one or more syringe pumps, an incubator comprised of one or more cell cultures, an autosampler connected to a peristaltic pump, and a multi-line switch valve in communication with the incubator. The multi-line switch valve is configured to add one or more of media, PBS, quenching reagent, or inactivation reagent to the one or more cell cultures. The computer controller mediates the injection of stimulus to the cell cultures via the one or more syringe pumps based on a computed temporal pump profile that determines the stimulus concentration over discrete time points.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• G01N 15/10 - Investigating individual particles

Abstract

fHb111), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.

IPC Classes  ?

• C07D 498/04 - Ortho-condensed systems
• C07D 498/08 - Bridged systems
• C07D 498/18 - Bridged systems
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine

Abstract

The present invention provides matrices for use in mass spectrometry, particularly matrix-assisted laser desorption/ionization mass spectrometry techniques. Methods of use, including for imaging mass spectrometry, of the presently disclosed matrices are also provided.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

The present disclosure provides for devices, systems, and methods of using electromagnetically actuated ophthalmic lens. The lens includes a first chamber and a second chamber, the second chamber being connected to the first chamber to form a central void. The lens further includes a membrane layer disposed between the first chamber and the second chamber in the central void, the membrane layer being flexible and with an inner ridge. Additionally, the lens includes an electromagnet disposed between the first chamber and the membrane layer, the electromagnet adjacent to the inner ridge of the membrane layer and a magnet disposed between the second chamber and the membrane layer, the magnet adjacent to the inner ridge of the membrane layer.

IPC Classes  ?

• G02C 7/02 - LensesLens systems
• G02C 7/06 - LensesLens systems bifocalLensesLens systems multifocal

Abstract

Structures for a photonic chip that include photonic device, such as a ring resonator, and methods of forming such structures. The structure comprises a waveguide core including a first section and a second section separated from the first section by a slot. The first section of the waveguide core includes a first side edge, a second side edge opposite from the first side edge, and a plurality of notches in the first side edge.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means

Abstract

The present disclosure relates to compositions and methods for treating and/or preventing malarial infections. In some embodiments, the present disclosure provides recombinant antibodies and compositions thereof for treating and/or preventing a malarial infection. The present disclosure also provides methods of using the recombinant antibodies and compositions thereof to treat and/or prevent a malarial infection.

IPC Classes  ?

• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 33/06 - Antimalarials
• C07K 14/445 - Plasmodium
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

A method includes generating, via a sensor, a signal representing vibrations originating from a blood vessel of a patient and processing the signal to yield amplitudes and phases of the vibrations that correspond to oscillation frequencies of the vibrations. The method also includes identifying a first subset of the amplitudes and a second subset of the phases that correspond to the oscillation frequencies that are integer multiples of a heart rate of the patient. The method also includes, in response to providing the first subset of the amplitudes and the second subset of the phases to a computational model, determining a health metric for the patient and generating, via a user interface, an output indicative of the health metric.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/024 - Measuring pulse rate or heart rate

Abstract

The present disclosure provides include kits, compositions, and methods related to impaired respiratory health (e.g., diseases and conditions relating to lung injury). In particular, the present disclosure provides include kits, compositions, and methods for quantifying protein biomarkers associated with impaired respiratory health and assessing the risk of, monitoring, treating and/or preventing, interstitial lung diseases (ILDs).

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A device may include a channel defined at least in part by a first surface and a second surface opposite and spaced apart from the first surface, the channel comprising a fluid inlet and a fluid outlet spaced apart from the fluid inlet in a flow direction. The device may include a metasurface array adjacent to the first surface of the channel, the metasurface array comprising (i) a first metasurface associated with a first transmission spectrum, and (ii) a second metasurface associated with a second transmission spectrum, the second metasurface being spaced apart from the first metasurface in the flow direction.

IPC Classes  ?

• G02B 1/06 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of fluids in transparent cells
• G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
• G02F 1/295 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection in an optical waveguide structure
• G02F 1/1337 - Surface-induced orientation of the liquid crystal molecules, e.g. by alignment layers
• B01L 1/00 - EnclosuresChambers

Abstract

The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. The present invention encompasses compounds of formula (V), wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

IPC Classes  ?

• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 35/00 - Antineoplastic agents
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

A method of treating a disease or condition characterized by increased activity of a methionine aminopeptidase (METAP) protein includes interfering with a transfer of Zn to the METAP protein from a Zn-regulated GPTase metalloprotein activator 1 (ZNG1) protein. A method of reducing an activity of a methionine aminopeptidase (METAP) protein is also provided, including interfering with a transfer of Zn to the METAP protein from a Zn-regulated GPTase metalloprotein activator 1 (ZNG1) protein

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-1 and methods for use thereof.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present disclosure relates to cross-reactive RSV/hMPV antibodies, RSV/hMPV antibody compositions, and methods of use thereof.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention encompasses compounds of formula (I), Formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W and L have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. The present invention encompasses compounds of formula (I), Formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W and L have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

IPC Classes  ?

• C07D 498/10 - Spiro-condensed systems
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

In some embodiments, the present disclosure relates to a method. The method includes accessing digitized pathology imaging data from a cancer patient. The digitized pathology imaging data has been generated using immunohistochemical (IHC) stained pathology images and has been segmented to identify a plurality of immune cells. The plurality of immune cells are used to extract a plurality of immune cell features from the digitized pathology imaging data. The plurality of immune cell features are operated upon by a machine learning stage that is trained to generate a medical prognosis relating to the cancer patient.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06V 10/00 - Arrangements for image or video recognition or understanding
• G16H 30/00 - ICT specially adapted for the handling or processing of medical images
• G06N 3/00 - Computing arrangements based on biological models

Abstract

Methods, apparatus, systems, and articles of manufacture are disclosed for generation and application of models for therapeutic prediction and processing. A balance of precision and recall can be applied to at least one of a toxicity-related model or an efficacy-related model to configure immunotherapy treatment of a patient and/or cohort of patients. Model output can be evaluated differently depending on a determine patient selection criterion to trigger different actions.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

An interface for a wearable assistance device that comprises a sleeve that comprises a main body configured to at least partly surround a user's body segment and is adjustable for comfort and fit. The interface has an elastic portion. A stop is positioned adjacent to the elastic portion such that the stop bridges the elastic portion. The stop is configured to restrict an amount of stretch that the elastic portion affords the sleeve beyond a set length. An engagement feature configured to connect the interface to a component of the wearable assistance device.

IPC Classes  ?

• A61F 5/02 - Orthopaedic corsets

Abstract

The present disclosure relates to probes and methods for detecting and imaging ocular diseases.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleosidemodified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/29 - Hepatitis virus
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Soluble amyloid-b oligomers (SAbOs) accumulate early, prior to amyloid plaque formation. Because SAbOs may provide an earlier and more direct indication of disease progression, this makes them potentially better markers for detecting AD in its preclinical or early stages, when interventions may be more effective. The presently disclosed subject matter describes novel anti-SAbO nanobodies generated from an alpaca immunized with SAbO. The nanobody or fragment thereof that binds SAbO and optionally comprises a cargo molecule. Because of their small size as compared with antibodies, the disclosed nanobodies not only cross the blood brain barrier, but may also be able to cross cell membranes.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present disclosure is directed to antibodies binding to and neutralizing Eastern Equine Encephalitis Virus (EEEV) and methods for use thereof.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/04 - Antibacterial agents
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A tibial tray including a peripheral rim, a first recess surrounded by the peripheral rim, the first recess being recessed relative to the peripheral rim, a stem extending from the first recess, and a reservoir partially defined by the stem and configured to receive a contaminant.

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees
• A61F 2/30 - Joints
• A61F 2/64 - Knee joints

Abstract

Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy) piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy) piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems

Abstract

Disclosed herein are polysulfide microparticles that include a varying monomer composition. The monomer composition can control properties of the microparticles, such as crystallinity, which can aid in the production and stability of the microparticles. An example microparticle includes a polymer derived from monomers of propylene sulfide (PS) and ethylene sulfide (ES). The microparticles disclosed herein can be useful in drug delivery applications, such as treating inflammatory diseases. Also disclosed are methods of making the polysulfides and methods of making the microparticles.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61P 27/06 - Antiglaucoma agents or miotics

Abstract

An electronic computing device for defending files against ransomware. The electronic computing device includes an electronic processor. The electronic processor is configured to receive a selection of a file and convert the file to a protected file having a protected file format including storing data in an alternate data stream in the protected file. The electronic processor is also configured to detect an attempt to access the protected file and block access to the protected file in response to determining that the attempt to access the protected file is unauthorized.

IPC Classes  ?

• G06F 21/56 - Computer malware detection or handling, e.g. anti-virus arrangements
• G06F 21/78 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure storage of data
• G06F 21/57 - Certifying or maintaining trusted computer platforms, e.g. secure boots or power-downs, version controls, system software checks, secure updates or assessing vulnerabilities
• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity

Abstract

Disclosed herein is a method for identifying a subject with increased risk of developing a cardiometabolic disease or a hematological cancer, that involves the steps of (a) assaying a blood, serum, or plasma sample from the subject for circulating levels of myeloid zinc finger 1 (MZF1), anti-müllerian hormone (AMH), TIMP metallopeptidase inhibitor 1 (TIMP1), glycine N-methyltransferase (GNMT), or a combination thereof; and (b) comparing the circulating levels of MZF1, AMH, TIMP1, GNMT, or a combination thereof, to control values, wherein presence of elevated circulating levels of MZF1, AMH, TIMP1, GNMT, or a combination thereof indicates an increased risk of developing a cardiometabolic disease and/or a hematological cancer.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/26 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones

Abstract

The present disclosure provides for devices, systems and methods of debriding and treating abscesses and infections affecting a cavity, bone, joint, or other area of the body. The present disclosure provides for devices, systems, and methods described herein that allows percutaneous or endoscopic placement (ultra-minimally invasive) of at least a delivery tube and at least an evacuation tube (e.g., using a catheter) to allow for debridement and treatment of spine infections, septic joints, abscess cavities and the like with a greatly reduced morbidity compared to an open surgical approach.

IPC Classes  ?

• A61B 17/32 - Surgical cutting instruments
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

A sample transportation system, in particular embodiments, comprises: a housing; at least one gyroscope sensor disposed within the housing; a substantially linear track disposed within the housing; a sample receptacle slidably coupled to the substantially linear track; and at least one motor in mechanical communication with at least one of the sample receptacle or the substantially linear track. In various embodiments, the at least one motor is configured to cause the sample receptacle to translate parallel to the substantially linear track with respect to the housing. In some embodiments, the system further comprises computing hardware configured to receive velocity data from the at least one gyroscope sensor, and operate the at least one motor to cause the sample receptacle to translate with respect to the housing based on the velocity data.

IPC Classes  ?

• B65G 51/36 - Other devices for indicating or controlling movements of carriers, e.g. for supervising individual tube sections, for counting carriers, for reporting jams or other operating difficulties

Abstract

Described herein are benzothiazole-phenyl-sulfonyl-piperidine compounds for activating N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD).

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

The present disclosure relates to methods of using a human parainfluenza virus 3 (HPIV3) neutralizing antibody to prevent and/or treat HPIV infections.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A device may include a flexible outer surface configured to extend over at least a palm, forming a palm side surface comprising (i) a first surface region adjacent to and covering a metacarpophalangeal (MCP) joint of a user's hand, and (ii) a second surface region adjacent to a wrist opening defined by the flexible outer surface. The device may include a constriction region on the palm side surface, the constriction region disposed between the first surface region and the second surface region such that the first and second surface regions are in opposition. The device is movable between a first default configuration and a second configuration. Movement between the first default and second configuration includes the constriction region pulling the opposing first and second surface regions of the palm side surface towards each other to bend and maintain the MCP joint to a desired angle.

IPC Classes  ?

• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

A hair manipulation mechanism for use with an optrode of a functional near-infrared spectroscopy (fNIRS) system. The hair manipulation mechanism including a body defining a central axis, and a plurality of comb elements. Where each comb element includes at least one leg extending therefrom that is configured to engage the one or more hairs of the entity, and where each comb element of the plurality of comb elements is adjustable between a first position, in which the comb element is spaced a first radial distance from the central axis, and a second, position, in which the comb element is spaced a second radial distance from the central axis greater than the first distance.

IPC Classes  ?

• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/026 - Measuring blood flow

Abstract

A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in men and women. Uncontrolled proliferation of CRC cells is pivotal in colorectal tumorigenesis and cyclooxygenase-2 (COX-2) is an important regulatory enzyme in this process. Timely diagnosis is the key to life-saving management of CRC, which is under-diagnosed because colorectal aberrant crypt foci, hyper plastic polyps, micro edemas are often missed with conventional colonoscopy. Disclosed herein are imaging agents tagged to nanobodies specific for COX-2 protein that can selectively accumulate and retain in COX-2 expressing cells and colorectal adenomas, resulting in specific and sensitive of early detection, while reducing background and off-target systemic toxicity. The prospect of combining structural and functional imaging readouts obtained with fluorescence-aided colonoscopy measurements would provide powerful diagnostic information for improved management of colorectal carcinogenesis.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/31 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes

Abstract

A method for generating a magnetic resonance (MR) image in the presence of an interventional device that induces distortions is provided. The method includes using a processor to perform steps that include accessing a distorted MR image of a subject with the interventional device arranged in the subject. The steps also include using the distorted MR image to determine parameters of a set of spatially differentiable functions that describe an estimated position of the interventional device in the subject. The steps further include determining a magnetic susceptibility map based on susceptibility properties of the interventional device and the estimated position of the interventional device. The steps also include generating a simulated MR image by modifying a reference image of the subject based on the magnetic susceptibility map and updating the estimated position using the simulated MR image to generate an updated position of the interventional device in the subject.

IPC Classes  ?

• G01R 33/28 - Details of apparatus provided for in groups
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 17/34 - TrocarsPuncturing needles
• G01R 33/48 - NMR imaging systems
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The presently-disclosed subject matter relates to humanized rodent HER2 sequences. Embodiments of the presently-disclosed subject matter include polypeptides and nucleic acids, cells comprising such polypeptides and such nucleic acids, and genetically-modified rodents. Embodiments of the presently-disclosed subject matter include methods for assessing a candidate therapeutic that contains trastuzumab, pertuzumab, derivatives thereof, and/or drug conjugates thereof.

IPC Classes  ?

• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
• C07K 14/82 - Translation products from oncogenes
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

An Inertial Measurement Unit (IMU) is placed on a robot and outputs inertial information such as angular velocity and linear acceleration of the tip to which it is attached. A robot controller implements a recursive estimation algorithm to fuse robot encoder values with IMU data to determine a statistically optimized estimated position of the robot tip.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

Abstract

A knee prosthesis includes a shank link, a thigh link rotatably coupled to the shank link and at least one powered control element configured to apply a torque between the thigh link and the shank link. The shank motion is described by at least a shank angular velocity relative to an inertial reference frame. The knee prosthesis further comprises at least one sensor, and a controller. The controller is configured to: receive sensor measurements from the at least one sensor and determine a present state of a plurality of states including at least a swing state and a stance state; and provide torque control for the at least one powered control element if the present state is a swing state. The knee prosthesis measures the shank angular velocity. The torque control is a function of at least the shank angular velocity.

IPC Classes  ?

• A61F 2/64 - Knee joints
• A61F 2/70 - Operating or control means electrical

Abstract

The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided. The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided. The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided. 1 5-methyl-6- (3-pyrrolidin- 1-1-7,8- dihydro-5H-1,6- naphtbyridin- 6-yl)pyridine- 3-carbonitrile 320.2

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/538 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Goods & Services

Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research

Abstract

Systems and methods for pharyngeal phenotyping in obstructive sleep apnea are described herein. An example method includes receiving manometry data for a subject; extracting a plurality of features from the manometry data, where the extracted features include one or more of a high-level breath feature, a frequency feature, or a largest negative connected component (LNCC) feature; inputting the extracted features into a trained machine learning model; and predicting, using the trained machine learning model, at least one of a location of pharyngeal collapse for the subject or a degree of pharyngeal collapse for the subject.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

A method of treating or ameliorating an inflammatory autoimmune response, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.

IPC Classes  ?

• C07D 213/65 - One oxygen atom attached in position 3 or 5
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• C07C 215/50 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
• C07C 217/58 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain

Abstract

A surgical image guidance system, including: a processing circuit including a processor and memory, the memory having instructions stored thereon that, when executed by the processor, cause the processing circuit to: receive, from an optical device, surface data characterizing a surface of a portion of soft tissue; receive, from an intraoperative imaging device, subsurface data characterizing a subsurface of the portion of soft tissue, wherein the subsurface includes a region of interest; measure, based on the surface data, deformation of the surface of the portion of soft tissue; update, based on at least one of (i) the deformation of the surface and (ii) the subsurface data, a model including a representation of the region of interest; and transmit a visual representation of the model to be displayed to a user.

IPC Classes  ?

• A61B 34/32 - Surgical robots operating autonomously
• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

One aspect of the invention provides a blood pump system comprising a blood pump configured to provide a blood flow in an extracorporeal membrane oxygenation (ECMO) circuit for extracorporeal physiological support for a patient; a magnetic coupling member configured to drive the blood pump to operably provide the blood flow; a direct current (DC) motor configured to drive the magnetic coupling member, thereby driving the blood pump; and a controller configured to regulate a motor speed of the DC motor.

IPC Classes  ?

• A61M 60/122 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body

Abstract

A nanotweezer including an anapole nanoantenna having a double nanohole formed through a central region of the anapole nanoantenna, a spacer layer positioned between the anapole nanoantenna and a reflector layer, and a light source configured to illuminate the reflector layer. Upon illumination of the reflector layer by the light source, an optical gradient force is generated at the double nanohole.

IPC Classes  ?

• H01Q 19/10 - Combinations of primary active antenna elements and units with secondary devices, e.g. with quasi-optical devices, for giving the antenna a desired directional characteristic using reflecting surfaces
• H01Q 1/42 - Housings not intimately mechanically associated with radiating elements, e.g. radome
• H01Q 15/14 - Reflecting surfacesEquivalent structures

Abstract

Disclosed herein are block copolymers that can self-assemble into particles, which can be used to crosslink a hydrophilic polymer. An example block copolymer includes a first block that includes pendant groups that can modulate reactive oxygen species responsiveness and drug interactions, a second block that is hydrophilic, and a third block that is hydrophilic and includes a grafted guest-host moiety. Also disclosed are compositions including the block copolymers, and methods of treating diseases.

IPC Classes  ?

• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials

Abstract

In one aspect, the disclosure relates to pharmaceutical compositions containing LPAR5 agonists including, but not limited to, compounds and methods for treating diseases and disorders associated with a mutation in Myosin Vb (MYO5B), decreased lysophosphatidic acid receptor 5 (LPAR5) expression, or both using the same. In one embodiment, the disclosed compositions and kits may be particularly useful in treating microvillus inclusion disease (MVID) and the diarrhea and malabsorption associated with the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

A waveguide assembly for delivering focused acoustic energy includes a housing comprising a chamber filled with a medium for propagating acoustic waves. An acoustic transducer is supported the housing and has a surface facing into the chamber. The surface is configured to transmit acoustic waves into the chamber through the medium toward a focus zone. The waveguide assembly also includes structure configured to focus the acoustic waves transmitted from the surface of the acoustic transducer. The waveguide assembly further includes a flexible elongated waveguide having a first end positioned in the chamber opposite the curved surface, and a second end outside the chamber. The waveguide has a tubular configuration with an inner lumen in fluid communication with the chamber via the first end and being filled with the medium. The first end of the waveguide is configured to be positioned in the focus zone so that the focused acoustic waves are propagated through the medium in the inner lumen of the waveguide.

IPC Classes  ?

• G10K 11/22 - Methods or devices for transmitting, conducting or directing sound for conducting sound through hollow pipes, e.g. speaking tubes
• G10K 11/30 - Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses

Abstract

444) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.

IPC Classes  ?

• C07D 495/14 - Ortho-condensed systems
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 25/20 - HypnoticsSedatives
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine

Abstract

Disclosed herein are lipophilic oligonucleotide conjugates that can bind to albumin. An example conjugate includes an oligonucleotide; a lipophilic ligand capable of binding albumin; and a linker attaching the oligonucleotide and the lipophilic ligand, the linker including a branching molecule attached to the oligonucleotide, and a hydrophilic spacer attaching the branching molecule and the lipophilic ligand. Also disclosed are compositions including the conjugate and methods of using the conjugate.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Abstract

A wearable weight distribution device that includes an upper-body interface, a lower-body interface, and at least one retractable load-bearing component comprising a first end connected configured to be detachably connected to the upper-body interface and a second end configured to be detachably connected to the lower-body interface. The retractable load-bearing component is configured to extend and retract. When the retractable load-bearing component is in an extended position, a load path is provided from the upper-body interface, through the retractable load-bearing component, and to the lower-body interface to transmit at least a portion of the load from the upper-body interface to the lower-body interface.

IPC Classes  ?

• A45F 3/04 - Sacks or packs carried on the body by means of two straps passing over the two shoulders
• A45F 3/06 - Sacks or packs carried on the body by means of two straps passing over the two shoulders specially adapted for military purposes
• B25J 9/00 - Programme-controlled manipulators

Abstract

A cation exchange nanoparticulate sulfonated polystyrene solution comprising a polymer, the polymer having at least one benzenesulfonate monomer and at least one Ca2+ calcium ion that is useful in the treatment of cancer.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Disclosed herein is a method for producing training data using a machine learning model trained with noisy annotated training data. The method includes receiving a plurality of anatomical images and corresponding molecular images, wherein each of a plurality of pairs of corresponding anatomical and molecular images captures a respective biological specimen. The method includes receiving at least one annotation on an anatomical image that is informed by its corresponding molecular image, wherein the at least one annotation identifies a functional unit of interest within the anatomical image. The method includes training a machine learning model using said annotated images, wherein the trained machine learning model is configured for multi-class functional unit segmentation.

IPC Classes  ?

• G06T 7/174 - SegmentationEdge detection involving the use of two or more images
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

Some T-cell receptors (TCRs) require many ligands for activation while others need only a few, functioning in analog or digital modes, correspondingly. Digital performance is best but undiscernible using conventional functional avidity or TCR sequence distance metrics. Correlates of optimal biophysical parameters include magnitudes of ERK phosphorylation, CD3 surface loss, and activation marker upregulation. The disclosed findings underscore the requirement to match TCR performance quality with pMHC copy number, as nature does. Given tumor antigen array paucity, engaging superior digital TCRs appears critical for T-cell adoptive cancer therapies and vaccines. Therefore, disclosed herein are methods for detecting digital T cell receptor interactions with presented antigen and selecting a T cell or antigen based on these methods. Also disclosed are adoptive cell transfer methods for treating a subject with digital T cells identified by the disclosed methods. In addition, disclosed are methods for designing RNA vaccines based on the copy number that elicits a digital T cell response.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 14/725 - T-cell receptors
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

A graphical user interface (GUI) for managing healthcare algorithms, wherein the GUI is configured to: simultaneously display (710), to a user, information associated with a number of models (410), wherein each of the number of models is configured to analyze a health metric of a patient; identify (720), to the user, an abnormal model from the number of models (440), wherein the abnormal model is operating outside a safety threshold (516); receive (730), from the user, input associated with the abnormal model (512); and cause (740) an action to be performed in response to receiving the input from the user.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G06N 20/00 - Machine learning
• G06F 3/048 - Interaction techniques based on graphical user interfaces [GUI]
• G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data

Goods & Services

Tops as clothing; Tops as clothing for men and women; Athletic tops; Knit tops; T-shirts; Long sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Blouses; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers

Goods & Services

Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events

Goods & Services

Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events

Goods & Services

Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research

Goods & Services

Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events

Goods & Services

Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events

Goods & Services

Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks

Goods & Services

Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Cardigans; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors

Goods & Services

Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks

Goods & Services

Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events

Goods & Services

Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research

Goods & Services

Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research

Goods & Services

Tops as clothing; Tops as clothing for men and women; Athletic tops; T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Hats; Headwear; Caps being headwear; Caps with visors

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeve shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Vests; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Sports bras; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Clothing jackets; Outerwear, namely, jackets; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery

Goods & Services

Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Uniforms; Athletic uniforms; Clothing, namely, cheerleading uniforms and apparel; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery

Abstract

This invention provides methods for treating endothelial dysfunction by administering an effective amount of citrulline to a patient. The patients may be suffering from acute respiratory distress syndrome (ARDS), sepsis, or infection by COVID-19 (Coronavirus Disease 2019); COVID-19 patients may be at risk of developing endothelial dysfunction, or they may be experiencing endothelial dysfunction. The effective amount of citrulline is sufficient to reduce the uncoupling of endothelial nitric oxide synthase (eNOS) or to reduce the formation of free radicals. Citrulline may be administered orally; intravenously; or both orally and intravenously in a sequential manner. Sequential administration of citrulline may be in three phases, such as (a) an initial phase in which citrulline is administered orally, (b) an intermediate phase wherein citrulline is administered intravenously, and (c) a final phase wherein citrulline is administered orally. The intermediate phase may be while the patient's breathing is being assisted mechanically.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Disclosed are methods for assessing the responsiveness of a patient to a Nuclear Transport Checkpoint Inhibitor (NTCI) as well as the efficacy of a NTCI treatment regimen. Additionally disclosed herein are methods of genomic diagnosing a subject with an inflammatory skin disease.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 17/00 - Drugs for dermatological disorders
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A haptic training system for developing skills and training for soft-tissue surgeries. The system includes one or more robotic arm assemblies and a computing device. The robotic arm assembly includes a frame, an upper manipulation linkage assembly coupled to the frame, a lower manipulation linkage assembly coupled to the frame, one or more actuators coupled to the upper manipulation linkage assembly or the lower manipulation linkage assembly, a tool stem assembly coupled to the upper manipulation linkage assembly and the lower manipulation linkage assembly, the tool stem assembly configured to support a surgical tool, and a sensor assembly coupled to the tool stem assembly. The computing device is configured to receive magnetic flux density data from the sensor assembly when a force is applied to the tool stem assembly, determine a position and an orientation of the tool stem assembly based on the magnetic flux density data, estimate forces of interaction with the upper manipulation linkage assembly and the lower manipulation linkage assembly based on electrical current of the one or more actuators, calculate an estimation of force at a distal end of the surgical tool based on the position and the orientation of the tool stem assembly and the forces of interaction, and process the estimation of force at the distal end of the surgical tool to provide real-time haptic feedback to the user via the surgical tool.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/35 - Surgical robots for telesurgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

Disclosed herein are (6-(4-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, (6-(4-(difluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, and (6-(2-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

IPC Classes  ?

• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings

Abstract

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases. The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

IPC Classes  ?

• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 35/00 - Antineoplastic agents
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Thromboxane A2 receptor antagonists, such as ifetroban, inhibit solid tumor metastasis. The formation of surface and microscopic lung metastases are inhibited. Thromboxane A2 receptor antagonists can inhibit the tumor metastasis process without affecting the growth or development of a primary tumor.

IPC Classes  ?

• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/04 - Antineoplastic agents specific for metastasis