Disclosed herein are polysulfide microparticles that include a varying monomer composition. The monomer composition can control properties of the microparticles, such as crystallinity, which can aid in the production and stability of the microparticles. An example microparticle includes a polymer derived from monomers of propylene sulfide (PS) and ethylene sulfide (ES). The microparticles disclosed herein can be useful in drug delivery applications, such as treating inflammatory diseases. Also disclosed are methods of making the polysulfides and methods of making the microparticles.
An electronic computing device for defending files against ransomware. The electronic computing device includes an electronic processor. The electronic processor is configured to receive a selection of a file and convert the file to a protected file having a protected file format including storing data in an alternate data stream in the protected file. The electronic processor is also configured to detect an attempt to access the protected file and block access to the protected file in response to determining that the attempt to access the protected file is unauthorized.
G06F 21/56 - Détection ou gestion de programmes malveillants, p. ex. dispositions anti-virus
G06F 21/78 - Protection de composants spécifiques internes ou périphériques, où la protection d'un composant mène à la protection de tout le calculateur pour assurer la sécurité du stockage de données
G06F 21/57 - Certification ou préservation de plates-formes informatiques fiables, p. ex. démarrages ou arrêts sécurisés, suivis de version, contrôles de logiciel système, mises à jour sécurisées ou évaluation de vulnérabilité
G06F 21/00 - Dispositions de sécurité pour protéger les calculateurs, leurs composants, les programmes ou les données contre une activité non autorisée
3.
MICROENVIRONMENTAL DETERMINANTS OF CLONAL HEMATOPOIESIS EXPANSION RATE
Disclosed herein is a method for identifying a subject with increased risk of developing a cardiometabolic disease or a hematological cancer, that involves the steps of (a) assaying a blood, serum, or plasma sample from the subject for circulating levels of myeloid zinc finger 1 (MZF1), anti-müllerian hormone (AMH), TIMP metallopeptidase inhibitor 1 (TIMP1), glycine N-methyltransferase (GNMT), or a combination thereof; and (b) comparing the circulating levels of MZF1, AMH, TIMP1, GNMT, or a combination thereof, to control values, wherein presence of elevated circulating levels of MZF1, AMH, TIMP1, GNMT, or a combination thereof indicates an increased risk of developing a cardiometabolic disease and/or a hematological cancer.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/26 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des hormones
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/74 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des hormones
A sample transportation system, in particular embodiments, comprises: a housing; at least one gyroscope sensor disposed within the housing; a substantially linear track disposed within the housing; a sample receptacle slidably coupled to the substantially linear track; and at least one motor in mechanical communication with at least one of the sample receptacle or the substantially linear track. In various embodiments, the at least one motor is configured to cause the sample receptacle to translate parallel to the substantially linear track with respect to the housing. In some embodiments, the system further comprises computing hardware configured to receive velocity data from the at least one gyroscope sensor, and operate the at least one motor to cause the sample receptacle to translate with respect to the housing based on the velocity data.
B65G 51/36 - Autres appareils pour indiquer ou commander les mouvements des cartouches, p. ex. pour contrôler des sections particulières de tubes, pour compter les cartouches, pour signaler les embouteillages ou autres difficultés de fonctionnement
5.
SYSTEMS AND METHODS FOR PERCUTANEOUS TREATMENT AND DEBRIDEMENT OF INFECTIONS
The present disclosure provides for devices, systems and methods of debriding and treating abscesses and infections affecting a cavity, bone, joint, or other area of the body. The present disclosure provides for devices, systems, and methods described herein that allows percutaneous or endoscopic placement (ultra-minimally invasive) of at least a delivery tube and at least an evacuation tube (e.g., using a catheter) to allow for debridement and treatment of spine infections, septic joints, abscess cavities and the like with a greatly reduced morbidity compared to an open surgical approach.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
6.
BENZOTHIAZOLE-PHENYLSULFONYL-PIPERIDINE ANALOGS AS ACTIVATORS OF NACYLPHOSPHATIDYLETHANOLAMINE HYDROLYZING PHOSPHOLIPASE D
Described herein are benzothiazole-phenyl-sulfonyl-piperidine compounds for activating N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD).
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
7.
HPIV3-NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure relates to methods of using a human parainfluenza virus 3 (HPIV3) neutralizing antibody to prevent and/or treat HPIV infections.
A device may include a flexible outer surface configured to extend over at least a palm, forming a palm side surface comprising (i) a first surface region adjacent to and covering a metacarpophalangeal (MCP) joint of a user's hand, and (ii) a second surface region adjacent to a wrist opening defined by the flexible outer surface. The device may include a constriction region on the palm side surface, the constriction region disposed between the first surface region and the second surface region such that the first and second surface regions are in opposition. The device is movable between a first default configuration and a second configuration. Movement between the first default and second configuration includes the constriction region pulling the opposing first and second surface regions of the palm side surface towards each other to bend and maintain the MCP joint to a desired angle.
A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
9.
HAIR COMB ATTACHMENT FOR FNIRS PROBES TO IMPROVE SNR AND SUBJECT INCLUSIVITY
A hair manipulation mechanism for use with an optrode of a functional near-infrared spectroscopy (fNIRS) system. The hair manipulation mechanism including a body defining a central axis, and a plurality of comb elements. Where each comb element includes at least one leg extending therefrom that is configured to engage the one or more hairs of the entity, and where each comb element of the plurality of comb elements is adjustable between a first position, in which the comb element is spaced a first radial distance from the central axis, and a second, position, in which the comb element is spaced a second radial distance from the central axis greater than the first distance.
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in men and women. Uncontrolled proliferation of CRC cells is pivotal in colorectal tumorigenesis and cyclooxygenase-2 (COX-2) is an important regulatory enzyme in this process. Timely diagnosis is the key to life-saving management of CRC, which is under-diagnosed because colorectal aberrant crypt foci, hyper plastic polyps, micro edemas are often missed with conventional colonoscopy. Disclosed herein are imaging agents tagged to nanobodies specific for COX-2 protein that can selectively accumulate and retain in COX-2 expressing cells and colorectal adenomas, resulting in specific and sensitive of early detection, while reducing background and off-target systemic toxicity. The prospect of combining structural and functional imaging readouts obtained with fluorescence-aided colonoscopy measurements would provide powerful diagnostic information for improved management of colorectal carcinogenesis.
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
11.
Magnetic Delivery System and Hydrogel Fixative for Therapeutic Cells
University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
Vanderbilt University (USA)
Inventeur(s)
Vorp, David A.
Ramaswamy, Aneesh Krishna
Weinbaum, Justin Sol
Blose, Kory James
Chung, Timothy Kwang-Joon
Kickliter, Trevor
Baruch, Yogev
Curci, John A.
Abrégé
A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
A method for generating a magnetic resonance (MR) image in the presence of an interventional device that induces distortions is provided. The method includes using a processor to perform steps that include accessing a distorted MR image of a subject with the interventional device arranged in the subject. The steps also include using the distorted MR image to determine parameters of a set of spatially differentiable functions that describe an estimated position of the interventional device in the subject. The steps further include determining a magnetic susceptibility map based on susceptibility properties of the interventional device and the estimated position of the interventional device. The steps also include generating a simulated MR image by modifying a reference image of the subject based on the magnetic susceptibility map and updating the estimated position using the simulated MR image to generate an updated position of the interventional device in the subject.
G01R 33/28 - Détails des appareils prévus dans les groupes
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
The presently-disclosed subject matter relates to humanized rodent HER2 sequences. Embodiments of the presently-disclosed subject matter include polypeptides and nucleic acids, cells comprising such polypeptides and such nucleic acids, and genetically-modified rodents. Embodiments of the presently-disclosed subject matter include methods for assessing a candidate therapeutic that contains trastuzumab, pertuzumab, derivatives thereof, and/or drug conjugates thereof.
C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
14.
INERTIA-BASED IMPROVEMENTS TO ROBOTS AND ROBOTIC SYSTEMS
An Inertial Measurement Unit (IMU) is placed on a robot and outputs inertial information such as angular velocity and linear acceleration of the tip to which it is attached. A robot controller implements a recursive estimation algorithm to fuse robot encoder values with IMU data to determine a statistically optimized estimated position of the robot tip.
A knee prosthesis includes a shank link, a thigh link rotatably coupled to the shank link and at least one powered control element configured to apply a torque between the thigh link and the shank link. The shank motion is described by at least a shank angular velocity relative to an inertial reference frame. The knee prosthesis further comprises at least one sensor, and a controller. The controller is configured to: receive sensor measurements from the at least one sensor and determine a present state of a plurality of states including at least a swing state and a stance state; and provide torque control for the at least one powered control element if the present state is a swing state. The knee prosthesis measures the shank angular velocity. The torque control is a function of at least the shank angular velocity.
A61F 2/70 - Moyens d'actionnement ou de commande électriques
16.
7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided.
1
5-methyl-6- (3-pyrrolidin- 1-1-7,8- dihydro-5H-1,6- naphtbyridin- 6-yl)pyridine- 3-carbonitrile
320.2
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/538 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes carbocycliques
A61K 31/553 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. loxapine, staurosporine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
The United States as Represented by the Department of Veterans Affairs (USA)
Inventeur(s)
Woodard, Lauren F.
Bejoy, Julie
Abrégé
Disclosed herein are nephron progenitor extracellular vesicles (EVs) that can be used to treat acute kidney injury and methods of using same. For example, disclosed herein is a composition involving nephron progenitor extracellular vesicles (EVs), wherein the EVs are produced by a method that involves: engineering donor cells to express exogenous SNAI2, EYA1, and SIX1, thereby producing induced nephron progenitor (iNP) cells, or obtaining nephron progenitor-like cells from less differentiated cell types including pluripotent stem cells such as induced pluripotent stem cells or embryonic stem cells; culturing the iNP or NPC cells in a culture medium, thereby producing a conditioned medium; and collecting and purifying nephron progenitor EVs from the conditioned medium.
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
19.
SYSTEMS AND METHODS FOR PHARYNGEAL PHENOTYPING IN OBSTRUCTIVE SLEEP APNEA
Systems and methods for pharyngeal phenotyping in obstructive sleep apnea are described herein. An example method includes receiving manometry data for a subject; extracting a plurality of features from the manometry data, where the extracted features include one or more of a high-level breath feature, a frequency feature, or a largest negative connected component (LNCC) feature; inputting the extracted features into a trained machine learning model; and predicting, using the trained machine learning model, at least one of a location of pharyngeal collapse for the subject or a degree of pharyngeal collapse for the subject.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G06N 20/10 - Apprentissage automatique utilisant des méthodes à noyaux, p. ex. séparateurs à vaste marge [SVM]
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
20.
METHOD FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
A method of treating or ameliorating an inflammatory autoimmune response, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
C07D 213/65 - Un atome d'oxygène lié en position 3 ou 5
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
C07C 215/50 - Composés contenant des groupes amino et hydroxy liés au même squelette carboné ayant des groupes hydroxy liés à des atomes de carbone d'au moins un cycle aromatique à six chaînons et des groupes amino liés à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné avec des groupes amino reliés au cycle aromatique à six chaînons, ou au système cyclique condensé contenant ce cycle par l'intermédiaire de chaînes carbonées qui ne sont pas substituées de plus par des groupes hydroxy avec des groupes amino et le cycle aromatique à six chaînons, ou le système cyclique condensé contenant ce cycle, liés au même atome de carbone de la chaîne carbonée
C07C 217/58 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés liés à des atomes de carbone d'au moins un cycle aromatique à six chaînons et des groupes amino liés à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons du même squelette carboné avec des groupes amino reliés au cycle aromatique à six chaînons, ou au système cyclique condensé contenant ce cycle, par l'intermédiaire de chaînes carbonées qui ne sont pas substituées de plus par des atomes d'oxygène liés par des liaisons simples avec des groupes amino et le cycle aromatique à six chaînons, ou le système cyclique condensé contenant ce cycle, liés au même atome de carbone de la chaîne carbonée
A surgical image guidance system, including: a processing circuit including a processor and memory, the memory having instructions stored thereon that, when executed by the processor, cause the processing circuit to: receive, from an optical device, surface data characterizing a surface of a portion of soft tissue; receive, from an intraoperative imaging device, subsurface data characterizing a subsurface of the portion of soft tissue, wherein the subsurface includes a region of interest; measure, based on the surface data, deformation of the surface of the portion of soft tissue; update, based on at least one of (i) the deformation of the surface and (ii) the subsurface data, a model including a representation of the region of interest; and transmit a visual representation of the model to be displayed to a user.
A61B 34/32 - Robots chirurgicaux opérant de façon autonome
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
22.
SMART PROGRAMMABLE BLOOD PUMP FOR CONTROLLING AND AUTOMATING EXTRACORPOREAL LIFE SUPPORT APPLICATIONS
One aspect of the invention provides a blood pump system comprising a blood pump configured to provide a blood flow in an extracorporeal membrane oxygenation (ECMO) circuit for extracorporeal physiological support for a patient; a magnetic coupling member configured to drive the blood pump to operably provide the blood flow; a direct current (DC) motor configured to drive the magnetic coupling member, thereby driving the blood pump; and a controller configured to regulate a motor speed of the DC motor.
A nanotweezer including an anapole nanoantenna having a double nanohole formed through a central region of the anapole nanoantenna, a spacer layer positioned between the anapole nanoantenna and a reflector layer, and a light source configured to illuminate the reflector layer. Upon illumination of the reflector layer by the light source, an optical gradient force is generated at the double nanohole.
H01Q 19/10 - Combinaisons d'éléments actifs primaires d'antennes avec des dispositifs secondaires, p. ex. avec des dispositifs quasi optiques, pour donner à une antenne une caractéristique directionnelle désirée utilisant des surfaces réfléchissantes
H01Q 1/42 - Enveloppes non intimement mécaniquement associées avec les éléments rayonnants, p. ex. radome
Disclosed herein are block copolymers that can self-assemble into particles, which can be used to crosslink a hydrophilic polymer. An example block copolymer includes a first block that includes pendant groups that can modulate reactive oxygen species responsiveness and drug interactions, a second block that is hydrophilic, and a third block that is hydrophilic and includes a grafted guest-host moiety. Also disclosed are compositions including the block copolymers, and methods of treating diseases.
In one aspect, the disclosure relates to pharmaceutical compositions containing LPAR5 agonists including, but not limited to, compounds and methods for treating diseases and disorders associated with a mutation in Myosin Vb (MYO5B), decreased lysophosphatidic acid receptor 5 (LPAR5) expression, or both using the same. In one embodiment, the disclosed compositions and kits may be particularly useful in treating microvillus inclusion disease (MVID) and the diarrhea and malabsorption associated with the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
A waveguide assembly for delivering focused acoustic energy includes a housing comprising a chamber filled with a medium for propagating acoustic waves. An acoustic transducer is supported the housing and has a surface facing into the chamber. The surface is configured to transmit acoustic waves into the chamber through the medium toward a focus zone. The waveguide assembly also includes structure configured to focus the acoustic waves transmitted from the surface of the acoustic transducer. The waveguide assembly further includes a flexible elongated waveguide having a first end positioned in the chamber opposite the curved surface, and a second end outside the chamber. The waveguide has a tubular configuration with an inner lumen in fluid communication with the chamber via the first end and being filled with the medium. The first end of the waveguide is configured to be positioned in the focus zone so that the focused acoustic waves are propagated through the medium in the inner lumen of the waveguide.
G10K 11/22 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour conduire le son par des tubes, p. ex. tuyaux acoustiques
G10K 11/30 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p. ex. balayage utilisant la réfraction, p. ex. lentilles acoustiques
27.
POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
Disclosed herein are lipophilic oligonucleotide conjugates that can bind to albumin. An example conjugate includes an oligonucleotide; a lipophilic ligand capable of binding albumin; and a linker attaching the oligonucleotide and the lipophilic ligand, the linker including a branching molecule attached to the oligonucleotide, and a hydrophilic spacer attaching the branching molecule and the lipophilic ligand. Also disclosed are compositions including the conjugate and methods of using the conjugate.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A wearable weight distribution device that includes an upper-body interface, a lower-body interface, and at least one retractable load-bearing component comprising a first end connected configured to be detachably connected to the upper-body interface and a second end configured to be detachably connected to the lower-body interface. The retractable load-bearing component is configured to extend and retract. When the retractable load-bearing component is in an extended position, a load path is provided from the upper-body interface, through the retractable load-bearing component, and to the lower-body interface to transmit at least a portion of the load from the upper-body interface to the lower-body interface.
A cation exchange nanoparticulate sulfonated polystyrene solution comprising a polymer, the polymer having at least one benzenesulfonate monomer and at least one Ca2+ calcium ion that is useful in the treatment of cancer.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
Disclosed herein is a method for producing training data using a machine learning model trained with noisy annotated training data. The method includes receiving a plurality of anatomical images and corresponding molecular images, wherein each of a plurality of pairs of corresponding anatomical and molecular images captures a respective biological specimen. The method includes receiving at least one annotation on an anatomical image that is informed by its corresponding molecular image, wherein the at least one annotation identifies a functional unit of interest within the anatomical image. The method includes training a machine learning model using said annotated images, wherein the trained machine learning model is configured for multi-class functional unit segmentation.
Some T-cell receptors (TCRs) require many ligands for activation while others need only a few, functioning in analog or digital modes, correspondingly. Digital performance is best but undiscernible using conventional functional avidity or TCR sequence distance metrics. Correlates of optimal biophysical parameters include magnitudes of ERK phosphorylation, CD3 surface loss, and activation marker upregulation. The disclosed findings underscore the requirement to match TCR performance quality with pMHC copy number, as nature does. Given tumor antigen array paucity, engaging superior digital TCRs appears critical for T-cell adoptive cancer therapies and vaccines. Therefore, disclosed herein are methods for detecting digital T cell receptor interactions with presented antigen and selecting a T cell or antigen based on these methods. Also disclosed are adoptive cell transfer methods for treating a subject with digital T cells identified by the disclosed methods. In addition, disclosed are methods for designing RNA vaccines based on the copy number that elicits a digital T cell response.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/557 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant des mesures cinétiques, c.-à-d. mesure de l'évolution en fonction du temps de l'interaction antigène-anticorps
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventeur(s)
Embi, Peter J.
Matheny, Michael E.
Davis, Sharon
Novak, Laurie
Sundrani, Sameer
Salwei Engebretsen, Megan Elizabeth
Nelson, Scott David
Abrégé
A graphical user interface (GUI) for managing healthcare algorithms, wherein the GUI is configured to: simultaneously display (710), to a user, information associated with a number of models (410), wherein each of the number of models is configured to analyze a health metric of a patient; identify (720), to the user, an abnormal model from the number of models (440), wherein the abnormal model is operating outside a safety threshold (516); receive (730), from the user, input associated with the abnormal model (512); and cause (740) an action to be performed in response to receiving the input from the user.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
Tops as clothing; Tops as clothing for men and women; Athletic tops; Knit tops; T-shirts; Long sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Blouses; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Cardigans; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Clothing jackets; Outerwear, namely, jackets; Hats; Headwear; Caps being headwear; Caps with visors
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing live and online instruction and training at the undergraduate, graduate, post-graduate and post-doctoral levels; Educational services, namely, providing live and online instruction at the university level; Educational services in the nature of courses at the university level; Educating at university or colleges; Organizing, arranging, operating and conducting forums, panels, lectures, discussions, seminars, symposiums, workshops, conferences and educational series in a variety of subjects at college or university level; Providing online non-downloadable multi-media content featuring news, images, photographs and audio-visual recordings relating to scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, mechanical and technical research and development; Libraries; Museum services; Providing virtual museum services via global communications networks; Museum exhibitions; Art exhibitions; Arranging and conducting special events for social entertainment purposes; Arranging and conducting social entertainment events; Live musical performances; Music education; Live dance performances; Instruction in the nature of dance camps and clinics; Providing facilities for entertainment events, namely, concerts, shows and live stage performances; Providing recreation facilities; Providing facilities for recreational activities; Providing facilities for use in playing games; Providing facilities for community sports and cultural programs; Providing interactive play areas and social gatherings for children; Arranging and conducting programs featuring recreational activities for children; Providing courses of instruction for children with individual needs; Providing courses of instruction at the primary level; Providing classroom instruction at the primary level; Instructional summer programs for academically advanced students; Academic enrichment programs for advanced students; Summer academies; Summer camps; Recreational camps; Sports camps; Arranging and conducting youth sports programs; Organizing social entertainment events for entertainment purposes for sports fans; Fan clubs; Organizing community sporting and cultural events; Organizing and conducting games; Organizing, arranging, operating and conducting collegiate athletic and sporting events; Organizing, arranging, operating and conducting sports competitions; Entertainment in the nature of competitions in the field of athletics; Entertainment services, namely, live appearances by a costumed character; Entertainment services, namely, cheerleading; Entertainment services, namely, producing cheerleading, dance and spirit-related competitions and events; Instruction in the nature of cheerleading camps and clinics; Providing information in the field of collegiate athletics; Providing information relating to collegiate athletics; Providing information in the field of sports; Providing information relating to sports; Providing information relating to sporting events; Providing information relating to sports competitions; Providing online non-downloadable multi-media content featuring news, images and photographs relating to collegiate athletics programs and events; Providing online non-downloadable multi-media content featuring news, images and photographs relating to sports, sporting events and sports competitions; Providing online non-downloadable audio and video recordings relating to collegiate athletics programs and events; Providing online non-downloadable audio and video recordings relating to sports, sporting events and sports competitions; Providing sports information via a website; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to collegiate athletics programs and events; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content relating to sports, sporting events and sports competitions; Providing a website featuring non-downloadable articles, images, photographs, audio recordings, video recordings and audio-visual content on the topics of general entertainment interest; Providing entertainment information via a website; Providing entertainment information in the field of collegiate athletics; Providing entertainment information in the fields of sports, sporting events and sports competitions; Providing entertainment information in the field of collegiate athletics via global communications networks; Providing entertainment information in the fields of sports, sporting events and sports competitions via global communications networks; Providing sports facilities; Providing facilities for sporting events
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research; Scientific research and development; Interdisciplinary scientific research; Scientific research in the field of healthcare; Scientific investigations for medical purposes; Medical research; Biomedical research; Biological research; Pharmaceutical research; Pharmaceutical research and development; Pharmaceutical drug development services; Drug discovery services; Scientific study and research in the fields of biochemistry, disease, drug repurposing, drug rescue, genetics, medical diagnostics, medical treatment, personalized medicine, personalized therapeutics and pharmaceuticals; Mechanical research; Technical research in the field of engineering; Providing information in the fields of scientific, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development; Providing information in the fields of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research and development via global communications networks; Consulting services in the fields of design, planning and implementation project management of scientific, interdisciplinary, medical, biomedical, biological, pharmaceutical, technical, mechanical and interdisciplinary research
Tops as clothing; Tops as clothing for men and women; Athletic tops; T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Hats; Headwear; Caps being headwear; Caps with visors
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeve shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Pique shirts; Woven shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Skirts; Dresses; Clothing jackets; Outerwear, namely, jackets; Vests; Bodysuits; One-piece garments for children; Infant and toddler one piece clothing; Sports bras; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Polo shirts; Dress shirts; Button down shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Clothing jackets; Outerwear, namely, jackets; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
Tops as clothing; Tops as clothing for men and women; Tops as clothing for children; Athletic tops; Knit tops; Tank tops; Jerseys being clothing; T-shirts; Long-sleeve T-shirts; Shirts; Short-sleeved shirts; Sweaters; Sweatshirts; Hooded sweatshirts; Pullovers; Hooded pullovers; Bottoms as clothing; Pants; Shorts; Dresses; Uniforms; Athletic uniforms; Clothing, namely, cheerleading uniforms and apparel; Beachwear; Swimwear; Hats; Headwear; Caps being headwear; Caps with visors; Hosiery
53.
ACTION OF L-CITRULLINE TO PREVENT OR TREAT ENDOTHELIAL DYSFUNCTION
This invention provides methods for treating endothelial dysfunction by administering an effective amount of citrulline to a patient. The patients may be suffering from acute respiratory distress syndrome (ARDS), sepsis, or infection by COVID-19 (Coronavirus Disease 2019); COVID-19 patients may be at risk of developing endothelial dysfunction, or they may be experiencing endothelial dysfunction. The effective amount of citrulline is sufficient to reduce the uncoupling of endothelial nitric oxide synthase (eNOS) or to reduce the formation of free radicals. Citrulline may be administered orally; intravenously; or both orally and intravenously in a sequential manner. Sequential administration of citrulline may be in three phases, such as (a) an initial phase in which citrulline is administered orally, (b) an intermediate phase wherein citrulline is administered intravenously, and (c) a final phase wherein citrulline is administered orally. The intermediate phase may be while the patient's breathing is being assisted mechanically.
THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventeur(s)
Hawiger, Jack Jacek
Zienkiewicz, Jozef
Liu, Yan
Qiao, Huan
Abrégé
Disclosed are methods for assessing the responsiveness of a patient to a Nuclear Transport Checkpoint Inhibitor (NTCI) as well as the efficacy of a NTCI treatment regimen. Additionally disclosed herein are methods of genomic diagnosing a subject with an inflammatory skin disease.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
55.
SYSTEMS AND METHODS FOR ACCELERATED SKILL ACQUISITION AND ASSESSMENT FOR SURGICAL TRAINING
A haptic training system for developing skills and training for soft-tissue surgeries. The system includes one or more robotic arm assemblies and a computing device. The robotic arm assembly includes a frame, an upper manipulation linkage assembly coupled to the frame, a lower manipulation linkage assembly coupled to the frame, one or more actuators coupled to the upper manipulation linkage assembly or the lower manipulation linkage assembly, a tool stem assembly coupled to the upper manipulation linkage assembly and the lower manipulation linkage assembly, the tool stem assembly configured to support a surgical tool, and a sensor assembly coupled to the tool stem assembly. The computing device is configured to receive magnetic flux density data from the sensor assembly when a force is applied to the tool stem assembly, determine a position and an orientation of the tool stem assembly based on the magnetic flux density data, estimate forces of interaction with the upper manipulation linkage assembly and the lower manipulation linkage assembly based on electrical current of the one or more actuators, calculate an estimation of force at a distal end of the surgical tool based on the position and the orientation of the tool stem assembly and the forces of interaction, and process the estimation of force at the distal end of the surgical tool to provide real-time haptic feedback to the user via the surgical tool.
A61B 34/35 - Robots chirurgicaux pour la téléchirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
56.
ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Disclosed herein are (6-(4-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, (6-(4-(difluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine, and (6-(2-(trifluoromethyl)pyridin-3-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.
The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
Thromboxane A2 receptor antagonists, such as ifetroban, inhibit solid tumor metastasis. The formation of surface and microscopic lung metastases are inhibited. Thromboxane A2 receptor antagonists can inhibit the tumor metastasis process without affecting the growth or development of a primary tumor.
The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 14/50 - Facteur de croissance des fibroblastes [FGF]
Identifying a fibroblast subtype in a thyroid cancer involves obtaining a fine needle aspiration (FNA) biopsy sample from a subject, the sample including nucleic acids; assaying the nucleic acids in the sample for an increase in the amount of mRNA produced by genes of a fibroblast gene signature relative to a control level of mRNA produced by the genes in a sample obtained from a healthy subject; and identifying the fibroblast subtype if there is an increase in the amount of mRNA in the sample relative to the control level.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
61.
METHODS AND APPARATUS FOR INTRAOPERATIVE ASSESSMENT OF PARATHYROID GLAND VASCULARITY USING LASER SPECKLE CONTRAST IMAGING AND APPLICATIONS OF SAME
One aspect of the invention relates to an apparatus for assessment of parathyroid gland viability comprising a diffuser configured to diffuse a beam of light onto a tissue surface of a parathyroid gland of a patient to illuminate the tissue surface; and means for obtaining speckle contrast images for the assessment of parathyroid gland viability.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
In one aspect, the disclosure relates to a dorsal spanning plate assembly comprising a first plate member that can be fixed to a bone or bone fragment distal to a distal radius fracture and a second plate member that can be fixed to a bone or bone fragment proximal to the distal radius fracture. In an aspect, the dorsal spanning plate assembly includes a joint such as, for example, a hinge joint or a ball-and-socket joint, wherein the joint is not fixed during placement of the dorsal spanning plate assembly. In still another aspect, a subject in whom the dorsal spanning plate assembly is implanted retains some range of motion in the fractured joint, thereby reducing muscle atrophy and retaining joint flexion during recovery. Also disclosed are methods of setting bone fractures using the dorsal spanning plate assembly.
Disclosed herein is a custom platform called NSC-seq that can be used for cell lineage and cell division tracking in a temporal fashion but also with single-cell resolution. With simultaneous integration of single-cell transcriptomics with lineage barcoding and temporal recording information, NSC-seq facilitates the generation of multidimensional datasets for elucidating functional heterogeneity and clonal events in vivo. We apply this platform (i) to decipher lineage branching of mouse embryonic development, (ii) to record clonal dynamics of the adult intestinal epithelium, and (iii) to track clonal composition of the mouse intestinal tumors. In addition, we apply NSC-seq to assess a comprehensive gene expression phenotype for individual gene knockout at the single-cell level using existing whole-genome CRISPR knockout screening plasmid libraries. Overall, NSC-seq enables in vivo temporal recording of mammalian development and cancer at single-cell resolution.
Systems and methods are provided for evaluating an adaptive radiotherapy system. An apparatus includes a housing formed from a first material having a first appearance under a selected imaging modality and a target that is inserted into the housing. The target includes a plurality of target components formed from a second material having a second appearance under the selected imaging modality. The plurality of target components are manipulable to assume at least a first configuration comprising a first subset of the plurality of target components and a second configuration comprising a second subset of the plurality of target components that is different from the first subset of the plurality of target components.
Methods and systems for automatic segmentation of structures of interest of an organ in an MR image. The method includes creating a weighted active shape model (wASM); registering model points of the structures in an MR atlas image to a target image that is the MR image to be segmented, as initial model points of the structures in the target image; and iteratively fitting the wASM to the target image, starting from the initial model points, until the shape converges, wherein the final shape is the segmentation of the structures of interest.
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
66.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
67.
ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
Methods and apparatus for generating intraocular overlay patterns in an optical microscope. In one example, an intraocular overlay pattern is generated using a digital micromirror device located in the intermediate focal plane of a telecentric optical relay coupled between the objective lens and an eyepiece of the optical microscope. In some examples, the overlay pattern displays real-time visualization of intraoperative optical coherence tomography data and surgical field overlays. Such overlay patterns can beneficially be used, e.g., to provide real-time intraoperative feedback during ophthalmic surgery substantially without any interference with the surgical workflow.
Methods and apparatus for quantifying an injected volume in an area of tissue during a medical procedure. In one example, a method includes determining a pixel-to-size scale parameter based on a pixelated image of a reference object included in a FOV of an optical instrument configured to perform volumetric imaging, the FOV further including an injection site; computing a first 3D model of the injected volume in the area of tissue based on a volumetric image of the FOV obtained using the optical instrument; refining the first 3D model to obtain a second 3D model of the injected volume, the refining including correcting a shape and a size of the first 3D model to reduce distortions associated with light refraction at a boundary of the injected volume in the area of tissue; and calculating a value of the injected volume based on the second 3D model and further based on the pixel-to-size scale parameter.
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
Systems, methods, and kits useful for detecting and locating internal bleeding, such as gastrointestinal bleeding, during active or inactive bleeding. In some embodiments, the systems, methods, and kits make use of a single photon emission computed tomography (SPECT) tracer. The kit for preparing a technetium-99m (99mTc)-labeled composition for targeting an injured site in a blood vessel, comprising: -a conjugated human fibrinogen, wherein the human fibrinogen is bonded to a chelating agent selected from the group consisting of diethylene triamine pentaacetate (DTPA) dianhydride.
The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
Disclosed herein are methods for treating or reducing symptoms of preterm labor or decreasing preterm birth in a subject. The methods include administering to the subject a therapeutically effective amount of a compound for tocolytic use.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/472 - Isoquinoléines non condensées, p. ex. papavérine
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
A61L 27/26 - Mélanges de matériaux macromoléculaires
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 31/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
75.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
76.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
77.
POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
Deuterium-labeled 4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidines substituted with pyrrolo[3,4-b]pyridin-5-one, furo[3,4-b]pyridin-5(7H)-one, or [1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
78.
Supermere Nanoparticles and Methods of Isolation and Use Thereof
Disclosed herein is a newly identified secreted nanoparticle that is morphologically and molecularly distinct from the recently described nanoparticle termed an exomere. The disclosed nanoparticle is referred to herein as a supermere. Both exomeres and supermeres are amembranous in contrast to membrane-enclosed extracellular vesicles (EVs). Supermeres are smaller and morphologically distinct from exomeres. These supermeres contain cargo with diagnostic and therapeutic applications.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
Disclosed herein are protein-based compositions and conjugates thereof that can take advantage of beneficial delivery properties to improve vaccine efficacy. An example protein-based composition includes an albumin-binding nanobody and a peptide antigen domain. An example conjugate includes the protein-based composition attached to a drug through a linker. Also disclosed are methods of making and using the protein-based compositions and conjugates thereof.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The present invention discloses a method for reducing inflammation in a subject by administering an effective amount of anacardic acid (AA) or a pharmaceutically acceptable salt thereof. Anacardic acid, represented by the chemical structure, has been found to exhibit anti-inflammatory properties when administered to a subject in need thereof. The method provides a novel approach to treating inflammation by utilizing anacardic acid or its pharmaceutically acceptable salt, offering a promising therapeutic option for managing inflammatory conditions in subjects.
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective amount of ifetroban or a pharmaceutically acceptable salt thereof.
A handheld imaging system comprises a light delivery member optically coupled with a light source for delivering light emitted from the light source to tissue of a target region to illuminate the tissue; and an imaging member for detector for collecting the images of optical signals emitted from the tissue responsive to the light illumination. The light delivery member and the imaging member are incorporated into a handpiece.
The disclosed system predicts the biological age of skeletal remains using a convolutional neural network (trained, for example, using 693 radiographs from 136 adults interred in lead coffins in the eighteenth and nineteenth centuries in the crypt of London's St. Bride's Church). Additionally, to increase explainability and minimize the risk of overfitting, the disclosed system uses backpropagation to generate heatmaps that localize relevant regions of the skeletal remains that are class-discriminative (i.e., most important to the model in predicting the age-at-death).
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
85.
SMOOTH MUSCLE CELLS SEEDED IN MICROCHANNELS WITHIN HYDROGELS TO FORM FUNCTIONAL MEDIAL LAYERS IN ENGINEERED MICROVASCULATURE
In one aspect, the disclosure relates to engineered microvessels including a microchannel formed in a hydrogel material; and a medial layer including a plurality of mural cells such as, for example, smooth muscle cells and/or pericytes; wherein each one of the plurality of mural cells is in contact with a wall of the microchannel; and wherein the plurality of mural cells are helically aligned at an angle relative to a lengthwise axis of the microchannel. The microvessels have narrow diameters consistent with resistance microvessels such as small resistance arteries and arterioles and tunable stiffness resulting from degree of crosslinking within the hydrogel material. Also disclosed are methods of making the microvessels, microvessel networks including the microvessels, and engineered organs and tissues including the microvessels. Furthermore, disclosed is a method for inducing vasoconstriction and vasodilation in the microvessels, networks, and engineered organs and tissues.
The second most common CHIP mutation, Ten eleven translocase 2 (TET2), is known to produce worse atherosclerosis in models of atheroprone mice, potentially through an inflammatory mechanism. Disclosed herein is an important modulator in the initiation and progression of atherosclerosis formation in the setting of TET2 inactivation. Macrophage migration inhibitory factor (MIF), a chemokine, was Identified as a highly expressed signaling pathway in single cell analysis of TET2 CHIP patients. In a large population, a MIF single nucleotide variant (SNV) resulting in increased MIF production was correlated with increased coronary disease in the setting of TET2 inactivation. Moreover, MIF inhibition was found to reduce the atherosclerotic burden in atheroprone mice with TET2 inactivation.
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
87.
POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
5,6,7,8-Tetrahydro-1,6-naphthyridines substituted in the 6-position with pyrimido[1,2-b]pyridazin-4-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
5,6,7,8-Tetrahydro-1,6-naphthyridines substituted in the 6-position with pyrimido[1,2-b]pyridazin-4-one are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) and may have use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/5383 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes hétérocycliques
Skin biomolecular profile assessment methods and systems that can analyze the molecular composition of the skin using molecular-level, user-specific data to assess an individual's skin state and/or disease state are described herein. An example method includes receiving skin data associated with a subject, where the skin data includes a biomolecular profile. The method also includes inputting the skin data into a trained artificial intelligence (AI) model and receiving, from the trained AI model, a skin care prediction.
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
89.
SIMULTANEOUS DETECTION OF ANTIGENS AND ANTIGEN SPECIFIC ANTIBODIES IN A GUINEA PIG MODEL SYSTEM
Disclosed herein are methods of determining broadly neutralizing antibodies, antigen specific cell sorting and developing vaccine compositions in a guinea pig model system using LIBRA-seq.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
Disclosed are various approaches for a sensor, having a rotating magnetic spinner disposed at a first end of a shaft and configured to rotate about the shaft. The sensor can include a foot disposed at a second end of the shaft and a plurality of microspikes disposed on a distal surface of the foot.
G01N 11/16 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau en mesurant l'effet d'amortissement sur un corps oscillant
A dynamic organ storage system includes an insulating container with a lid enclosing an internal volume. Within the internal volume, an organ container with a lid that houses an organ submerged in perfusate, the lid includes at least one inlet port and at least one outlet port. At least one pressure bag, storing more of the perfusate, is tilted at an angle above the organ container. At least one infusion line enters the organ container via the at least one inlet port and connecting the at least one pressure bag to the organ to gravity flow the perfusate into the organ. A sampling line connected to the organ exits the organ container through the at least one outlet port for a user to monitor a condition of the organ. At least one cooling mechanism maintains the organ at a hypothermic temperature for a time without requiring power.
Disclosed are various approaches for an apparatus having a tubular member which has a radially external side and a radially internal side. The apparatus can further include a plurality of artificial cilia disposed circumferentially on the radially internal side of the tubular member, where the plurality of artificial cilia forming arrays extending longitudinally along the radially internal side of the tubular member.
A61F 2/48 - Moyens d'actionnement ou de commande, p. ex. de l'extérieur du corps, commande de sphincters
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61F 2/04 - Éléments ou organes creux ou tubulaires, p. ex. vessies, trachées, bronches ou voies biliaires
94.
ELECTROCHEMICAL ION PUMPING DEVICES AND METHODS OF USE THEREOF
Disclosed herein are electrochemical ion pumping devices and methods of use thereof. Also disclosed are Ion diffusion across electrode and IBM films. Concentrations of the diluate and brine in experiments with spontaneous ion diffusion across commercial cation exchange membrane (CEM), cation electrode (CE), and conventional electro-sorption electrode without ion exchange polymer filler.
H01M 8/08 - Éléments à combustible avec électrolytes aqueux
C22B 3/24 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés physiques, p. ex. par filtration, par des moyens magnétiques par adsorption sur des substances solides, p. ex. par extraction avec des résines solides
H01M 4/86 - Électrodes inertes ayant une activité catalytique, p. ex. pour piles à combustible
B82Y 40/00 - Fabrication ou traitement des nanostructures
95.
GENERATION OF HUMAN ALLERGEN- AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
Described herein are methods, systems and computer program products for individualized, non-invasive brain stimulation for enhanced learning. In some instances, high spatial-resolution and/or high temporal-resolution brain data is predicted based on new low spatial-resolution and/or new low temporal-resolution brain data using trained artificial intelligence (AI).
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
G16H 20/70 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mentales, p. ex. la thérapie psychologique ou le training autogène
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 5/242 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques
A61B 5/291 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
Disclosed herein are conjugates that can effectively deliver nucleic acid agonists to biological environments. An example conjugate includes a block copolymer including a first block that is hydrophilic, a second block that is hydrophobic, and a linking unit that covalently attaches a nucleic acid agonist to the block copolymer. Also disclosed are particles including self-assembled conjugates, methods of treating diseases, and methods of modulating RIG-I activity in a cell.
A61K 47/58 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. poly[méth]acrylate, polyacrylamide, polystyrène, polyvinylpyrrolidone, alcool polyvinylique ou résine d’acide sulfonique de polystyrène
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A machine vision system may include a meta-imager including a meta-optic and a polarization-sensitive photodetector. A machine vision system may further include and at least one processor operably coupled to the polarization-sensitive photodetector, and at least one memory operably coupled to the at least one processor. A machine vision system may be configured to: receive, from the polarization-sensitive photodetector, a plurality of feature maps; input, into a trained artificial neural network, the plurality of feature maps; and process, using the trained artificial neural network, the plurality of feature maps to recognize an object.
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
G02B 5/32 - Hologrammes utilisés comme éléments optiques
G06F 18/21 - Conception ou mise en place de systèmes ou de techniquesExtraction de caractéristiques dans l'espace des caractéristiquesSéparation aveugle de sources
This disclosure provides methods for treatment comprising co-administering insulin and glucagon to a subject, and co-formulations comprising insulin and glucagon.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
100.
APPARATUS AND METHODS OF SUBLIMATION FOR REPEATABLE UNIFORM OR PATTERNED DEPOSITION OF MATRIX CRYSTALS ON SOLID SUBSTRATES
This disclosure relates to apparatus and methods for sublimation and deposition of chemicals. In particular aspects, this disclosure relates to apparatus and methods for patterned sublimation and deposition of chemicals for use in matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). In specific aspects, the apparatus comprises a vacuum chamber and a template comprising a planar surface containing the chemical to be sublimed, where the template is located within the vacuum chamber.
