The present invention provides compositions and methods for inducing CRISPR/Cas-based editing of a target nucleic acid (e.g., target DNA or target RNA), or modulating the expression of a target nucleic acid, in vitro or in a cell, using modified guide RNAs (gRNAs) that incorporate one or more chemically-modified nucleotides. In some aspects, these modified gRNAs provide superior performance under challenging conditions.
Systems and methods for analysis of samples(217), the method can include providing a sample loop (225)disposed between a first valve(210)and a second valve(215); providing a pump(230) disposed downstream of the second valve(215); providing a sample container(245) disposed upstream of the first valve(210); engaging the pump(230) at a first time to modify a pressure inside the sample loop(225) from a first pressure to a second pressure less than the first pressure; opening the first valve(210) at a second time subsequent to the first time to flow a sample (217)through the first valve(210) into the sample loop(225). The pump(230)can be configured to remain fluidically connected to the sample loop(225) and turned on at the second time.
Systems and methods for analysis of samples are described herein. The method can include providing a sample loop disposed between a first valve and a second valve. The method can include providing a pump disposed downstream of the second valve. The method can include providing a sample container disposed upstream of the first valve. The method can include engaging the pump at a first time to modify a pressure inside the sample loop from a first pressure to a second pressure less than the first pressure. The method can include opening the first valve at a second time subsequent to the first time to flow a sample through the first valve into the sample loop. The pump can be configured to remain fluidically connected to the sample loop and turned on at the second time.
In some examples, an apparatus may include a leak-detection sensor circuit, at least one hardware processor, and a memory storing machine-readable instructions that, when executed by the at least one hardware processor, cause the at least one hardware processor to receive, from the leak-detection sensor circuit, sampled leak-detection data for a potential leak. The machine-readable instructions, when executed by the at least one hardware processor, further cause the at least one hardware processor to process the sampled leak-detection data with respect to noise and signal fluctuations, determine, based on the processed sampled leak-detection data, a first derivative and a second derivative, and generate, based on the first derivative and the second derivative, an indication of whether the potential leak represents an actual leak.
G01M 3/16 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
The disclosure provides binding agents (e.g., antibodies) against a human Claudin-18.2 protein, as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting, e.g., a pancreatic cancer, a gastric cancer, a colo-rectal cancer, an ovarian carcer, a lung cancer, or an esophageal cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
An ion pump is equipped with a monitoring system that, by monitoring the temperature present inside the ion pump, makes it possible to determine whether the ion pump is in an OFF state or an ON state while an electric potential difference is being applied between the pump electrodes. The monitoring system further makes it possible to assess the ON state or OFF state of the ion pump even when the ion pump is operating under low-pressure conditions, with an electric current below the minimum value detectable by conventional reading scales. A method for operating the ion pump utilizes the monitoring system to assess the ON/OFF state of the ion pump while an electric potential difference is being applied between the pump electrodes.
The present invention provides methods and kits to improve the signal from sialic acids labeled with the dye 1, 2-diamino-4, 5-methylenedioxybenzene (“DMB”). The methods include labeling the sialic acids with DMB in an aqueous solution comprising the amino acid glycine, with pH adjusted to 1.5-3.2 by an acid, such as phosphoric acid or hydrochloric acid, and a reductant.
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Manufacturing services for others in the field of drugs for
therapeutic use in humans, nucleic acids, and nucleic acid
materials; custom manufacturing consultancy; technical
support services, namely, providing technical advice related
to the manufacture of drugs for therapeutic use in humans,
nucleic acids, and nucleic acid materials.
09 - Scientific and electric apparatus and instruments
Goods & Services
Software for laboratory instruments sold as an integral
component of gas chromatography instruments, namely,
downloadable and recorded computer software and firmware for
automated system readiness, for instrument operation, for
predictive monitoring that tracks usage and provides alerts
when maintenance is needed, for instrument maintenance and
troubleshooting, and for providing a user interface at the
instrument touchscreen and via a network connected web
browser.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary use of non-downloadable cloud-based
software as a service to facilitate the interaction and
management of laboratory instruments, scientific data and
business process electronic data; providing temporary use of
non-downloadable cloud-based software for controlling
laboratory instruments, collecting, analyzing, interpreting,
and managing laboratory data, and creating and exporting
reports; providing temporary use of non-downloadable
computer software for use in research and diagnostic
laboratories for laboratory automation, visualization, data
reporting and analysis.
12.
ANALYSIS DEVICE WITH PARALLEL OPERATION OF SECONDARY FUNCTIONS
An analysis device, in particular for a sample separation device, for performing an analysis, is configured for executing a primary function which is directly associated with performing the analysis, and executing a first secondary function and a second secondary function which are indirectly associated with performing the analysis. The first secondary function and the second secondary function are performed at least temporarily in parallel with one another.
A method for operating an analysis device, in particular a sample separation device, for performing an analysis includes setting a determined equilibrium value as a control value for a controlled variable of the analysis device, the equilibrium value having been determined in advance by controlling at least one control variable of the analysis device to a target value and determining the resulting equilibrium value of a controlled variable of the analysis device in response to the controlling of the at least one control variable. The method also includes controlling the at least one control variable to the target value such that the control value of the controlled variable is complied with in the process.
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.
B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/26 - Selective adsorption, e.g. chromatography characterised by the separation mechanism
B01D 29/58 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in series connection arranged concentrically or coaxially
A pressure sensor includes an electromechanical element, which is configured to change its shape depending on a pressure applied to the pressure sensor and to output an electromagnetic characteristic that is based on the shape change. The pressure sensor also includes frame element with a surface, against which the electromechanical element is pressed by the applied pressure to cause the shape change.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 19/06 - Means for preventing overload or deleterious influence of the measured medium on the measuring device or vice versa
Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a Combined Positive Score (CPS) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.
Systems and methods for modular fluidic systems and methods for parallel capillary electrophoresis are described herein. The system can include a housing, a manifold assembly, and a reservoir assembly. The manifold assembly can include a manifold connector. The reservoir assembly can include a reservoir and a reservoir connector. In a first configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a first volume. In a second configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a second volume different from the first volume.
Systems and methods for modular fluidic systems and methods for parallel capillary electrophoresis are described herein. The system can include a housing, a manifold assembly, and a reservoir assembly. The manifold assembly can include a manifold connector. The reservoir assembly can include a reservoir and a reservoir connector. In a first configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a first volume. In a second configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a second volume different from the first volume.
A resin formed of copolymer beads is disclosed. The copolymer beads have a first repeating motif, a second repeating motif having a substituted styrene with an ester functional group or an amide with a terminal amine or hydroxyl functional group, and a crosslinking agent having a divinyl compound. The copolymer beads are capable of expanding substantially uniformly in polar and non-polar solvents.
C08F 212/14 - Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing hetero atoms
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 19/073 - Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
C07H 19/167 - Purine radicals with ribosyl as the saccharide radical
20.
METHODS OF ANALYZING LIPID NANOPARTICLES IN PHYSIOLOGICAL FLUIDS
An interference ion removal device used in a mass spectrometry system or the like comprises a first ion guide and a second ion guide, a DC potential barrier being formed between the first ion guide and the second ion guide. In the first ion guide, collision-induced dissociation (CID) and kinetic energy discrimination (KED) are performed, and in the second ion guide, the velocity distribution of ions is caused to converge.
The disclosure provides binding agents (e.g., antibodies) against a human Hepatitis A virus cellular receptor 2 protein (TIM3), as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting Non-Small Cell Lung Cancer (NSCLC) and/or other types of lung cancer, Head and Neck Squamous Cell Carcinoma (HNSCC), Hepatocellular Carcinoma (HCC) or other types of liver cancer, Renal cell carcinoma, malignant melanoma, gastro-intestinal cancer, colorectal cancer, urothelial carcinoma and other types of bladder cancer, mamma carcinoma and/or other types of breast cancer, ovarian cancer, cervical cancer, prostate cancer, pancreatic cancer, lymphoma/leukemia, malignant mesothelioma, or a cancer in another organ or cell type.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
The invention relates to a liquid detector (100) for an analysis device (10), wherein the liquid detector (100) has: i) a temperature sensor device (120) for determining a temperature characteristic (132) over time in response to a provided temperature pulse (131); and, ii) an evaluation device (130) for evaluating a liquid characteristic on the basis of the determined temperature characteristic (132).
G01N 25/02 - Investigating or analysing materials by the use of thermal means by investigating changes of state or changes of phaseInvestigating or analysing materials by the use of thermal means by investigating sintering
G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
25.
ELECTROACTIVE CHAMBER PUMP SYSTEM AND METHOD FOR OPERATING THE SAME
ZEMA ZENTRUM FÜR MECHATRONIK UND AUTOMATISIERUNGSTECHNIK GGMBH (Germany)
AGILENT TECHNOLOGIES, INC. (USA)
Inventor
Ziegler, Tony
Wagner, Joachim
Plachetka, Clemens
Baltes, Matthias
Croce, Sipontina
Motzki, Paul
Abstract
Chamber pump system comprising at least one chamber pump (1) comprising a deformable chamber membrane (8) defining a pump chamber (9), an electroactive elastomer transducer (13) mechanically coupled with the chamber membrane (8) to actuate the chamber membrane to change the volume of the pump chamber (9), and a control unit (15) for periodically energizing the electroactive elastomer transducer (13) to induce a reciprocating motion of the chamber membrane (8) according to an actuation frequency; wherein the control unit (15) is configured to set the actuation frequency depending on at least one of an operating pressure and a total electrical power consumption.
F04B 35/04 - Piston pumps specially adapted for elastic fluids and characterised by the driving means to their working members, or by combination with, or adaptation to, specific driving engines or motors, not otherwise provided for the means being electric
F04B 43/00 - Machines, pumps, or pumping installations having flexible working members
09 - Scientific and electric apparatus and instruments
Goods & Services
Software for laboratory instruments sold as an integral component of gas chromatography instruments, namely, downloadable and recorded computer software and firmware for automated system readiness, for instrument operation, for predictive monitoring that tracks usage and provides alerts when maintenance is needed, for instrument maintenance and troubleshooting, and for providing a user interface at the instrument touchscreen and via a network connected web browser
27.
Smartphone display screen or portion thereof with transitional graphical user interface for instrument run control
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment for preparing samples for life science
research, namely, apparatus and instruments for automated
liquid handling, fluidics and sample storage, sample
transfer, and downloadable and recorded software for
equipment operation and control and for the transfer and
sharing of data.
A detector for an analytical device for analyzing a fluidic sample includes a housing, a lamp seat arranged in the housing and configured to receive a lamp for generating an electromagnetic radiation, and a movement mechanism to swivel the lamp seat with respect to the housing, and/or move the lamp seat between an operating orientation and a service orientation, so that the movement from the service orientation to the operating orientation results automatically in an electric contact and/or a mechanical positioning, in particular alignment, of the lamp.
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
(1) Manufacturing services for others in the field of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials; custom manufacturing consultancy; technical support services, namely, providing technical advice related to the manufacture of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials.
31.
ANTI-HUMAN ICOS ANTIBODIES FOR USE IN IMMUNOHISTOCHEMISTRY (IHC) PROTOCOLS AND FOR DIAGNOSING CANCER
In alternative embodiments, provided are chimeric, synthetic or recombinant anti-human ICOS protein or polypeptide (also called inducible T-cell co-stimulator, or Cluster of Differentiation-278, or CD278) antibodies (Abs), including products of manufacture and kits comprising them, and methods for making and using them, including for example their use in the detection or diagnosis, and treatment, of a cancer, or other diseases or conditions involving expression of ICOS. In alternative embodiments, anti-ICOS proteins (for example, antibodies) as provided herein are used together with an agent for determining whether ICOS expression or activity is present, increased, reduced or absent. In alternative embodiments, anti-ICOS antibodies as provided herein are used in the diagnosis and/or treatment of a cancer or a tumor.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
In some examples, a multipole ion guide may include a plurality of electrode groups that are arranged circumferentially around an axis of the multipole ion guide. At least one electrode group of the plurality of electrode groups may include at least three electrodes that are disposed in a side-by-side configuration.
The present disclosure relates to hybridization buffers for use in hybridization, for example, for use in in situ hybridization (ISH). Hybridization buffers and compositions comprising a sulfone solvent and polyvinyl sulfonic acid or a salt thereof, and methods of making and using, the same are disclosed.
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Manufacturing services for others in the field of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials; Manufacturing process consulting; Technical support services, namely, providing technical advice related to the manufacture of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials
In some examples, a multipole ion guide may include a plurality of electrode groups that are arranged circumferentially around an axis of the multipole ion guide. At least one electrode group of the plurality of electrode groups may include at least three electrodes that are disposed in a side-by-side configuration.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Non-downloadable cloud-based software as a service to facilitate the interaction and management of laboratory instruments, scientific data and business process electronic data; non-downloadable cloud-based software for controlling laboratory instruments, collecting, analyzing, interpreting, and managing laboratory data, and creating and exporting reports; non-downloadable computer software for use in research and diagnostic laboratories for laboratory automation, visualization, data reporting and analysis
A coated capillary tube having a tunable resistance in an ion transfer device, including an inlet end in communication with an atmospheric-pressure ion source, an outlet end in communication with a vacuum region of a mass spectrometer, a body elongated along an axis from the inlet end to the outlet end, and an inside surface defining a bore having an inner diameter is disclosed. The coated capillary tube also includes a resistive coating on the inside surface of the capillary tube, in which the resistive coating includes at least one layer comprising oxides or nitrides of a metal and discrete metal particles of a different metal embedded therein.
C09D 1/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
C23C 16/04 - Coating on selected surface areas, e.g. using masks
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
38.
VIRTUAL STAIN MULTIPLEXING MODEL ARCHITECTURE FOR CHANGEABLE STAINING COLOR
The present disclosure relates to methods and apparatuses for generating virtual staining for an image of a biologic sample. Such virtual staining comprises obtaining a virtual stain concentration image including applying an artificial intelligence model to the image of a biologic sample. Moreover, a staining control parameter is set. Then, a virtual stain image is generated by processing the virtual stain concentration image according to the staining control parameter. In some exemplary implementations, there may be more than one virtual stain image generated using different respective staining control parameters. The generated virtual stain image(s) may be combined with the original (unstained image) to obtain a stained image.
Disclosed herein are methods of purifying oligonucleotides, for example, by separating double-stranded oligonucleotides from single-stranded oligonucleotides. Also provided are apparatuses for performed such methods. Also provided are double-stranded nucleic acid compositions and single-stranded nucleic acid compositions made using the methods and apparatuses disclosed herein. Also provided are methods of producing circular double-stranded nucleic acids.
A sample handler for handling a sample container includes a stationary optical sensor, a movable stage movable with respect to the stationary optical sensor, and an optical adapter arrangeable at the movable stage and configured for being moved by the movable stage to thereby adapt a view of the stationary optical sensor.
An analytical device includes a fluid compartment configured to accommodate a solvent, a blocking device configured to close an input and/or an output of the fluid compartment, a flow sensor and/or a pressure sensor coupled to the fluid compartment and configured to perform a measurement with respect to the solvent, a temperature change device coupled to the fluid channel and configured to perform a temperature change with respect to the fluid compartment, and a determination device, configured to determine a thermal property of the solvent based on the measurement and the temperature change.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Laboratory equipment for preparing samples for life science research, namely, apparatus and instruments for automated liquid handling, fluidics and sample storage, sample transfer, and downloadable and recorded software for equipment operation and control and for the transfer and sharing of data.
Systems for performing two-dimensional chromatography are disclosed. The system includes a first switching valve fluidly coupled to a first separation column. The system includes a second switching valve coupled to a second separation column. The second switching valve is fluidly coupled to the first switching valve. The system includes an input/output valve in fluid communication with the first switching valve and the second switching valve that is configured to direct one or more mobile phases to the first switching valve. The system includes a sampling valve fluidly coupled to the first switching valve that includes at least one fraction capturing device. Methods of separating compounds using the systems are disclosed. Methods of retrofitting existing two-dimensional chromatography systems are also disclosed.
G01N 30/46 - Flow patterns using more than one column
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
Systems for performing two-dimensional chromatography are disclosed. The system includes a first switching valve fluidly coupled to a first separation column. The system includes a second switching valve coupled to a second separation column. The second switching valve is fluidly coupled to the first switching valve. The system includes an input/output valve in fluid communication with the first switching valve and the second switching valve that is configured to direct one or more mobile phases to the first switching valve. The system includes a sampling valve fluidly coupled to the first switching valve that includes at least one fraction capturing device. Methods of separating compounds using the systems are disclosed. Methods of retrofitting existing two-dimensional chromatography systems are also disclosed.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
G01N 30/46 - Flow patterns using more than one column
In some examples, a lid may include a seal disposed on a bottom surface of the lid. The lid may include a top surface and the bottom surface. The lid may further include a plurality of springs formed on the seal, where at least one spring of the plurality of springs includes a cylindrical configuration.
In some examples, an apparatus may include an environmental sample analyzer that is executed by at least one hardware processor to analyze an environmental sample at a plurality of wavenumbers. A particle type identifier that is executed by the at least one hardware processor may isolate, based on the analysis of the environmental sample at the plurality of wavenumbers, particle types for a plurality of particles in the environmental sample.
G01N 15/0227 - Investigating particle size or size distribution by optical means using imagingInvestigating particle size or size distribution by optical means using holography
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
In some examples, a liquid chromatography (LC) preparative guard cartridge housing may include an inlet assembly. Further, the cartridge housing may include an outlet jaw assembly that is slidably and rotateably engageable with the inlet assembly to retain a cartridge between the inlet assembly and the outlet jaw assembly, and disengageable from the inlet assembly to release the cartridge.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded software for managing and
optimizing laboratory pathology workflows, namely, for
capturing and retrieving data from laboratory information
systems, laboratory instruments, and sample tracking
devices, for analyzing, storing, disseminating, and
reporting that data, for presenting and viewing that data in
dashboards, and for inventory management and workflow
optimization. Software as a service (SAAS) services featuring software for
managing and optimizing laboratory pathology workflows,
namely, for capturing and retrieving data from laboratory
information systems, laboratory instruments, and sample
tracking devices, for analyzing, storing, disseminating, and
reporting that data, for presenting and viewing that data in
dashboards, and for inventory management and workflow
optimization.
50.
FLEXIBLE CAPILLARY ARRAY DEVICE AND RELATED SYSTEMS AND METHODS
A capillary array device includes a flexible component allowing movement of at least part of the device relative to an array of capillaries, thereby allowing different materials to be loaded into the capillaries. The capillaries may be utilized to contain samples that are to be measured by a capillary electrophoresis (CE) instrument or other type of analytical instrument.
A method and system for seeding cells on a well plate is disclosed. According to the present disclosure, a cell concentrating device is used that positions the cells at a particular location on the bottom floor of each well. The cell concentrating device improved sensitivity and uniformity when conducting analysis on the cells.
A valve, such as for an analysis device for analyzing a fluidic sample, includes a stator element having a stator boundary surface and a rotor element having a rotor boundary surface. The stator element and the rotor element are arranged in an axial direction. The stator boundary surface and the rotor boundary surface are pressed against each other in the axial direction by an axial force. The axial force is fixed by a non-detachable connection.
The invention provides a sample delivery system for an analytical instrument, comprising: a valve assembly comprising one or more valves, the valve assembly configured to receive an external sample from a sample source; an external sample reservoir coupled via the valve assembly to a sample dilution junction, wherein the valve assembly is configurable to alternatively permit either (i) flow of the external sample from the sample source to the external sample reservoir or (ii) flow of the external sample from the external sample reservoir to the sample dilution junction; a first fluid pump to control a flow of the external sample from the external sample reservoir to the sample dilution junction; a second fluid pump to control a flow of diluent to the sample dilution junction, thereby diluting the external sample to produce a diluted sample; and an analysis sample reservoir configured to deliver an analysis sample contained therein to an analysis device of the analytical instrument, wherein the analysis sample reservoir is coupled via the valve assembly to the sample dilution junction, and wherein the valve assembly is configurable to alternatively permit either (i) flow of the external sample along a continuous flow path from the sample source to the analysis sample reservoir, thereby by-passing the external sample reservoir, or (ii) flow of the diluted sample from the sample dilution junction to the analysis sample reservoir.
G01N 1/38 - Diluting, dispersing or mixing samples
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
09 - Scientific and electric apparatus and instruments
Goods & Services
Downloadable and recorded software for controlling liquid
chromatography instruments and gas chromatography
instruments, for processing, reviewing, and reporting data
from chromatography instruments, and for viewing and
monitoring the status of laboratory instruments and
laboratory workflows.
In some examples, a multipole ion guide may include a plurality of printed circuit boards (PCBs) that are circumferentially arranged about a central axis to form a conduit. The multipole ion guide may be formed based on utilization of plated edges of the PCBs.
A bearing allows accurate monitoring of bearing conditions and includes a printed circuit board, which is fitted to the bearing and on which one or more sensors are preassembled. The bearing facilitates removal and replacement operations and includes a first electrical cable and a second electrical cable removably connected to each other. The bearing is particularly suitable for applications to rotary vacuum pumps, especially turbomolecular pumps, in which the bearing is under vacuum conditions and the rotating shaft rotates at very high speed, so that high precision in the design and operation of the bearing is required and risks of contamination and/or of losing vacuum tightness must be carefully avoided.
Silica-coated magnetic nanoparticles with greater ability to remain dispersed, and methods of making and using silica-coated magnetic nanoparticles, including incubation of an aqueous dispersion of newly made particles at room temperature for a time period resulting in clusters of silica-coated magnetic nanoparticles, the resulting clusters being of an optimal size for viral RNA extraction from human clinical samples. The magnetic nanoparticles comprise a core and a coating, where the core comprises Fe3O4 or other magnetic material and the coating has a thickness of from about 1.5 nm to about 2 nm. The magnetic nanoparticles are useful for preparing nucleic acids for analysis, by separating nucleic acids from other components and by normalizing nucleic acid concentrations.
The disclosure provides binding agents (e.g., antibodies) against human TIGIT, as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting ovarian cancer, squamous cell carcinoma of the head and/or neck, non-small cell lung cancer, cervical cancer, esophageal cancer, melanoma, breast cancer, hepatocellular cancer, colorectal cancer, gastric cancer, renal cell carcinoma, prostate cancer, pancreatic cancer, bladder cancer, lymphoma, metastatic cancer, and/or a solid tumor in, on, or derived from any human tissue or organ.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
59.
PEEK-TO-PEEK THERMAL BONDING METHOD FOR PEEK MANIFOLDS
Methods for directly bonding two or more articles of polycthcr ether ketone (PEEK) arc provided. The method includes treating bonding surfaces on the two or more articles of PEEK. The method includes placing the treated bonding surfaces of the two or more articles of PEEK into contact with each other. The method further includes heating the two or more articles of PEEK for a pre-determined time at a pre-determined temperature between 250 °C and the melting point of the PEEK. The method additionally includes applying a pre-determined compressive load to the two or more articles of PEEK during heating. Fluid handling devices, such as manifolds and filters, formed using methods of the disclosure are also disclosed.
Impedance-based determination of metrics derived from Cytopathic Effects (CPE), such as Tissue Culture Infections Dose (TCID) values, is provided via determining a first plurality of cellular impedances (CI) corresponding to a plurality of cell samples while performing the impedance assay; inoculating the plurality of cell samples with a plurality of different dilutions of the virus such that a first and second subsets of the plurality of cell samples are respectively inoculated with first and second dilutions of a virus; determining, after inoculating the plurality of cell samples, a second plurality of CIs; determining, from the first plurality of CIs and the second plurality of CIs, cytopathic effects (CPE) experienced by the plurality of cell samples; calculating, a CPE-derived metric.
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Downloadable and recorded software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization. (1) Software as a service (SAAS) services featuring software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization.
An analytical device, in particular for analyzing a fluidic sample, includes a fluid drive configured to stream a first solvent and a second solvent along a flow path, so that the first solvent and the second solvent are streamed as a mixture at least during a time period. A determination device is configured to determine a value of a physical parameter with respect to the streaming of the mixture along the flow path, for at least two measurements each with a different mixing ratio of the first solvent and the second solvent, thereby determining at least two measurement results. An evaluation device is configured to compare the at least two determined measurement results with a reference, and to derive an information associated with the first solvent and/or the second solvent based on the comparison.
A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a liquid accommodation volume for accommodating the gas-containing liquid during degassing, a negative pressure chamber in which a negative pressure, compared to the liquid accommodation volume, is to be generated, a gas permeable membrane separating the liquid accommodation volume from the negative pressure chamber and arranged so that ultrasound forces at least part of gas of the gas-containing liquid to move through the membrane by a combination of the negative pressure and the ultrasound, and an ultrasound source including an electroactive material and configured for generating ultrasound for actuating the gas-containing liquid and/or the gas permeable membrane.
A sample probe accessory is disclosed. The sample probe accessory has a cylindrical body portion having an opening on a proximal end dimensioned to fit a distal end of the sample probe. The sample probe accessory has a filter positioned within the cylindrical body portion. The sample probe accessory has a cone portion extending from a distal end of the cylindrical body portion having a bottom aperture on a vertex of the cone portion. Also disclosed is a sample introduction subsystem for a spectrometer, including the sample probe accessory.
In some examples, a peek line column connect may include a connector including a peek line bore for insertion of a tube. A fastener may be removably insertable into one end of the connector to retain the tube when the fastener is moved in a first direction to further move a ferrule to contiguously engage the connector, and release the tube when the fastener is moved in a second direction that is opposite to the first direction to disengage the ferrule from the connector.
A method and system are disclosed for measuring a constituent of a sample. In one aspect, the sample can be a biological material. The method and system place a sensor in association with a sample. Excitation light is shown onto the sensor and a signal is detected from the sensor. A lens structure is positioned between the light source and the sensor for improving uniformity, intensity, and/or accuracy of the detected signal.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization Software as a service (SAAS) services featuring software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization
69.
COLLET, DEVICES, AND METHODS FOR INSTALLATION OF FLUIDIC CONDUITS TO FLUIDIC COMPONENTS
A collet includes a cap, a conduit grasper, a collet bore, and a collet slot. The grasper is composed of a flexible material such that the grasper is compressible in response to an applied force. A conduit such as a column is installed in a fluidic component by passing the conduit through the collet and into a fluidic coupling device. The collet is then coupled to the fluidic coupling device so as to compress the grasper against the column, thereby securing the column in the fluidic coupling device. The conduit may then be inserted into the fluidic component, and fluidic coupling device may be coupled to the fluidic component to complete the conduit installation. The collet or at least the cap may then be removed by moving the collet or at least the cap around the column via the collet slot. The grasper may be removed via a grasper slot.
Pipetting systems, devices, and methods are disclosed. An automated pipettor includes a pipette tip, a syringe, and a pressure sensor. The pipette tip is to aspirate a fluid from a container and/or dispense the fluid onto a target surface. The syringe is fluidically connected to the pipette tip. The pressure sensor is to collect pressure data. The pressure data is indicative of an air pressure in the pipette tip and/or the syringe. A processor is configured to determine the air pressure throughout the aspiration event and/or the dispensing event based on the pressure data. The processor is configured to identify when the fluid being aspirated is liquid or air based on changes in the air pressure during an aspiration event. The processor is configured to identify when the fluid being dispensed is liquid or air based on changes in the air pressure during a dispensing event.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
The present disclosure relates to chromogenic conjugates including a chromogenic moiety and a peroxidase substrate moiety, methods of chromogenic analysis, such as ImmunoHistoChemistry (IHC) and Chromogen In Situ Hybridization (CISH), and methods of making chromogenic conjugates.
C12Q 1/28 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase involving peroxidase
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
G01N 33/535 - Production of labelled immunochemicals with enzyme label
C09B 69/10 - Polymeric dyesReaction products of dyes with monomers or with macromolecular compounds
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Custom manufacturing in the field of biopharmaceuticals and pharmaceuticals; contract manufacturing in the biotechnology field, namely, fill and finish of biologics and drug substances for others; manufacturing process consulting; providing technical information in the field of pharmaceutical manufacturing.
(2) Development and production of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; research in the field of biopharmaceuticals and pharmaceuticals; engineering services in the field of biorefining and biomanufacturing processes and consultation related thereto; laboratory services using fermentation for biomanufacturing; biochemical research and analysis; quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals.
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing of biopharmaceuticals and pharmaceuticals; Manufacturing process consulting; Providing technical information in the field of pharmaceutical manufacturing Development of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; Research in the field of biopharmaceuticals and pharmaceuticals; Engineering services in the field of biorefining and biomanufacturing processes and consultation related thereto; Laboratory services using fermentation for biomanufacturing; Biochemical research and analysis; Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical compositions, reagents, chemical additives, and biochemical preparations for use in the manufacture of pharmaceuticals and biopharmaceuticals; Chemical compositions, reagents, chemical additives, and biochemical preparations, all for scientific research use in the fields of pharmaceuticals and biopharmaceuticals Chemical reagents for pharmaceutical purposes; Chemical reagents for medical purposes; Biological reagents for medical purposes; Diagnostic reagents for medical use Custom manufacturing in the field of biopharmaceuticals and pharmaceuticals, namely, chemical additives and reagents; Manufacturing process consulting; Providing technical information in the field of pharmaceutical manufacturing; Custom manufacturing of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, and medicaments for others Development of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; Research in the field of biopharmaceuticals and pharmaceuticals; Engineering services; Laboratory services using fermentation for biomanufacturing; Biochemical research and analysis; Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals
09 - Scientific and electric apparatus and instruments
Goods & Services
downloadable and recorded software for controlling liquid chromatography instruments and gas chromatography instruments, for processing, reviewing, and reporting data from chromatography instruments, and for viewing and monitoring the status of laboratory instruments and laboratory workflows
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment for preparing samples for life science research, namely, laboratory apparatus for automated handling, transfer, and storage of liquid specimens, liquid reagents, and liquid samples; Downloadable and recorded software for controlling the operation of laboratory apparatus for the automated handling, transfer, and storage of liquid specimens, liquid reagents, and liquid samples; Downloadable and recorded software for transferring data to and from automated laboratory apparatus and for the transfer and sharing of data
77.
SAMPLE SEPARATION DEVICE WITH ACTIVELY DAMPING METERING DEVICE
A sample separation device for separating a fluidic sample includes a fluid drive arrangement for driving a mobile phase along a flow path to a sample separation unit, a sampler for sampling the fluidic sample, and a control device configured to control the metering device to thereby actively damp a fluctuation in the fluid drive arrangement operation. The sampler may include a metering device.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
78.
METHODS OF PREPARING NUCLEIC ACIDS FOR SEQUENCING AND METHYLATION ANALYSIS
The present invention relates to preparation, sequencing and methylation analysis of nucleic acids. Input nucleic acids are attached, to methylated adaptors or tagged adaptors, or tagged primers are hybridized to the input nucleic acids, and tagged primer extension products are synthesized. Input nucleic acid can be separated from primer extension products or amplicons, and can be treated with a base conversion reagent with or without separation. Target sequences in tagged and untagged nucleic acid molecules can be captured for target enrichment.
The present invention relates to preparation, sequencing and analysis of nucleic acids. The nucleic acids are prepared, by attaching a first tag to an input nucleic acid. The first tag comprises a binding partner of a first binding pair. A second tag comprises a. reciprocal binding partner of the first binding pair. The second tag is attached to the first tag to produce an input nucleic acid complex, thereby indirectly tagging the input nucleic acid with the second tag.
Methods, kits and compositions for selectively tagging RNA molecules and for separating RNA sequences from DNA sequences. Methods for analysis of RNA sequences by preparing tagged cDNA molecules which can be separated from DNA molecules. The DNA molecules can be subjected to different preparation steps than the tagged cDNA molecules.
A microtiter plate assembly is disclosed that includes a base having a plurality of wells, a lid having a lid and a plurality of projections corresponding to the plurality of wells, a magnetic plate adapter including at least one magnet, and a force distribution plate that includes, or is coated with a magnetic or paramagnetic material. The magnetic plate adapter and the force distribution plate provide an amount of force necessary to reduce warping of large microtiter plate assays without increasing the footprint of the microtiter plate.
An implement for eliminating headspace in the testing space(s) (T9 or MPWell) of a test tube (T) or microtiter plate (MP), and methods of using such implements to measure oxygen concentration in a test sample. The implement projects into a test chamber (T9 or MPWell) to displace a portion of a fluid sample within the test chamber (T9 or MPWell) and has longitudinally extending grooves (109 and 229) through which the displaced fluidic content can be discharged from the test chamber (T9 or MPWell).
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
09 - Scientific and electric apparatus and instruments
Goods & Services
Molecular spectroscopy instruments, namely, spectrometers, spectrophotometers, fluorometers, densitometers, polarimeters, refractometers, ellipsometers, continuous flow analyzers, microscopy instruments, and molecular imaging apparatus, all for recording chemical quantities and optical properties of materials; Software and software platforms for use with laboratory equipment for acquiring, processing, reporting, analyzing, and storing scientific data, for searching and filtering the scientific data, and for performing calculations with the data.
84.
Tablet display screen or portion thereof with transitional graphical user interface
Provided herein is an ion source containing a plurality of components, at least one of which is partially coated with a layer of silicon. The ion source reduces reactivity between the sample and the carrier gas, reduces or eliminates tailing in ion chromatograms, and/or improves mass spectral fidelity. Also provided are methods of using the ion source in a mass spectrometer or gas chromatograph-mass spectrometer.
In an analytical device, a bubble, in particular a gas bubble, is detected by detecting in a fluid path an electromagnetic signal in response to a provided flow/pressure signal, and determining the presence of the bubble in the fluid path based on the detected electromagnetic signal.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
In some examples, an electron-based fragmentation (ExD) cell may include a container to enclose a filament cassette, and a first inlet that is configured to deliver gas into the container. The ExD cell may further include a second inlet that is configured to deliver ions to the filament cassette, and an ion exit opening.
A resin formed of copolymer beads is disclosed. The copolymer beads have a first repeating motif, a second repeating motif having a substituted styrene with an ester functional group or an amide with a terminal amine or hydroxyl functional group, and a crosslinking agent having a divinyl compound. The copolymer beads are capable of expanding substantially uniformly in polar and non-polar solvents.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H 1/00 - Processes for the preparation of sugar derivatives
The present invention provides an evaluation relating to quantification of a measurement sample using an inductively coupled plasma mass spectrometer. Pre-scanning of the measurement sample is performed to acquire pre-scan data, and quantitative scanning of the measurement sample is performed to acquire quantitative scan data for at least one target element. On the basis of a signal intensity acquired using the pre-scan data, the magnitude of spectral interference with respect to the signal intensity for the mass number corresponding to the at least one target element in the quantitative scan data is estimated, and the quantitative result for the at least one target element in the quantitative scan data is evaluated on the basis of the estimated magnitude of spectral interference.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
Provided is a method for predicting spectral interference in a mass spectrometry method employing an inductively coupled plasma mass spectrometry device. According to the present invention: a mass spectrometry method and an associated response coefficient are selected from a database in which a plurality of mass spectrometry methods each defining a mass spectrometry condition and a response coefficient indicating a correlation between an element and the signal strength of the element for each mass spectrometry method are stored; an application is selected from an application library in which applications specifying the types and contents of elements are collected; signal strengths indicating each element specified in the selected application and a signal strength indicating an interference component for each element are estimated; and spectral interference predicted for each element is displayed.
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
Methods and systems for carrier gas identification in gas chromatography are described herein. In one aspect, a gas chromatography system can include a pneumatic system including an input flowpath in fluidic communication with a first output flowpath and a second output flowpath; a first flow sensor configured to generate a flow measurement signal corresponding to a first property of a gas; a second flow sensor configured to generate a second flow measurement signal corresponding to a second property of the gas different than the first gas property; and a controller programmed to: determine the first flow measurement signal for the flow of gas through the pneumatic system; determine the second flow measurement signal for the flow of gas through the pneumatic system; and identify a type of gas for the flow of gas through the pneumatic system from the first and second flow measurement signals.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
G01N 30/30 - Control of physical parameters of the fluid carrier of temperature
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
The present disclosure relates to the field of biology. In particular, the present disclosure relates to polyclonal antibodies specific for lipoprotein (a) and methods of preparation and use related thereto. In some aspects, the anti-Lp(a) polyclonal antibodies are generated using a non-human animal host inoculated with a recombinant antigen comprising a sequence of an endogenous protein or portion thereof, modified to include one or more epitopes representative of individual amino acids or segments of amino acids in the polypeptide sequence of human Lp(a).
The present disclosure provides antibodies, including but not limited to monoclonal antibodies, capable of specifically binding the human PAX8 protein. Also provided are nucleic acids encoding the anti-PAX8 antibodies described herein, as well as expression vectors comprising these nucleic acids, host cells transformed with the expression vectors comprising the nucleic acids encoding the anti-PAX8 antibodies, and methods of making the antibodies. The anti-PAX8 antibodies described herein are useful for immunohistochemical detection of human PAX8 protein in tissue samples.
An analysis device for carrying out an analysis method includes multiple defined positions at which process fluids can be received. A defined position is selected. The selected position is mechanically provided to a user and/or a sample handling device. The selection is based on the content of the process fluids and/or a user behavior with respect to the process fluids. The analysis device may be configured for performing sample separation, such as by chromatography or electrophoresis.
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Reagents for scientific and research use; Diagnostic reagents and preparations, except for medical or veterinary use; Nucleic acid sequences and chemical reagents, other than for medical or veterinary purposes Biological reagents for medical purposes; Medical diagnostic reagents; Nucleic acid sequences and chemical reagents for medical purposes; Reagents for medical purposes
In order to provide an analysis method and device using laser ablation and a plasma ion source, without requiring a solid standard, embodiments include a plasma element analysis method and device, wherein a solution standard is atomized by a nebulizer and introduced into a plasma, calibration curve data for an element contained in the solution standard is created, a solid sample to be measured is atomized by laser ablation, the solid sample is introduced into the plasma together with an auxiliary liquid from the nebulizer and ionized, element analysis data is created, a concentration of a measured element in the solid sample is acquired from the element analysis data and the calibration curve data, and the concentration of the measured element is corrected and quantified.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/00 - Particle spectrometers or separator tubes
In some examples, an ion guide may include at least four rods spanning a portion of a circumference of the ion guide, and extending along a central axis of the ion guide. The ion guide may further include a plurality of electrodes. Each electrode of the plurality of electrodes may span a remaining portion of the circumference of the ion guide. Further, the plurality of electrodes may extend, in a side-by-side arrangement of electrodes of the plurality of electrodes, along the central axis of the ion guide.
Methods and systems for carrier gas identification in gas chromatography are described herein. In one aspect, a gas chromatography system can include a pneumatic system including an input flowpath in fluidic communication with a first output flowpath and a second output flowpath; a first flow sensor configured to generate a flow measurement signal corresponding to a first property of a gas; a second flow sensor configured to generate a second flow measurement signal corresponding to a second property of the gas different than the first gas property; and a controller programmed to: determine the first flow measurement signal for the flow of gas through the pneumatic system; determine the second flow measurement signal for the flow of gas through the pneumatic system; and identify a type of gas for the flow of gas through the pneumatic system from the first and second flow measurement signals.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
