Abstract

The invention provides a long acting curcumin derivative, preparation method and pharmaceutical use thereof, wherein said long acting curcumin derivative having the general structural formula disclosed herein, wherein R1 and R2 are hydrogen or methoxyl; R3 and R4 are each independently selected from C1-C50 alkyl. Compared with cuminoids, the inventive long acting curcumin derivative has a better release effect, a higher bioavailability and pharmaceutical activity, and thus can be useful for the treatment of diseases such as depression and cancer.

IPC Classes  ?

• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01N 37/06 - Unsaturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A61K 31/225 - Polycarboxylic acids
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring

Abstract

2+ and the like, and x=1.0˜2.0; y=3.0˜4.0. Compared with the prior art method, the present one is simpler, wider in application, and more operable.

IPC Classes  ?

• C04B 35/26 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on ferrites
• C04B 35/64 - Burning or sintering processes

Abstract

The present invention provides long acting curcumine derivates and preparation method and pharmaceutical use thereof. The said curcumine derivates have the following structure, wherein the R1 and R2 is hydrogen or methoxyl, R3 and R4 is C1-C50 alkyl group independently. The delayed release effect of curcumine derivates in the present invention is superior to curcuminoids, and the said derivates has high bioavailability and pharmacological activity, and can treat depression and cancer.

IPC Classes  ?

• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A23L 1/30 - containing additives (A23L 1/308 takes precedence);;
• C07C 69/017 - Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/035 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen esterified with a hydroxy compound having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/04 - Formic acid esters
• C07C 69/12 - Acetic acid esters
• C07C 69/22 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
• C07C 69/353 - Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom esterified with a hydroxy compound having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 69/52 - Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
• C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
• C07C 69/58 - Esters of straight chain acids with eighteen carbon atoms in the acid moiety
• C07C 69/612 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
• C07C 67/00 - Preparation of carboxylic acid esters
• A61K 9/08 - Solutions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 25/24 - Antidepressants
• A61P 35/00 - Antineoplastic agents

Abstract

A simple method of introducing magnetic particles into macromolecule to produce magnetic macromolecule. The method is characterized by using the macromolecule, which has an ability of adsorbing both of the trivalent iron ions (Fe3+) and other bivalent metal ions (M2+). At first, allow the macromolecule to absorb trivalent iron ions (Fe3+) and then adding alkali immediately, and secondly also, the macromolecule absorbs other bivalent metal ions (M2+) and then adding alkali immediately. As a result, the hydrous oxides of trivalent iron ions and the hydrous oxides of bivalent metal ions are both produced inside of the macromolecule successively. Then a heating treatment is performed, so that the hydrous oxides of trivalent iron ions and the hydrous oxides of bivalent metal ions are converted to a magnetic particles of MFexOy, wherein M may be Fe2+, Zn2+, Mg2+, Cu2+, Ca2+, Ba2+, Sr2+, Ni2+, Co2+ or Mn2+ and the like, and x = 1.0-2.0; and y = 3.0-4.0. Comparing to the method of the prior art, the method of the present invention is simpler and has broader field of application and can be operated more easily.

IPC Classes  ?

• C08J 3/20 - Compounding polymers with additives, e.g. colouring
• C08K 3/22 - OxidesHydroxides of metals
• C01G 49/00 - Compounds of iron
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates