Abstract

The present invention relates to a compound for treating fungal disease, wherein said compound provide target-specific inhibition of fungal adhesion, biofilm formation, and filamentation without affecting their growth, at very low concentration. The compound of the present invention is selected from FDA approved drugs Cangrelor. Further, the present invention provides a composition comprising compound of the present invention and a pharmaceutically acceptable carrier. Further, the present invention provides a method of treating fungal infections using the compound and/or composition of the present invention. Furthermore, uses of the compound and/or composition is also being provided in the present disclosure.

IPC Classes  ?

• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61P 31/10 - Antimycotics

Abstract

A method of fabricating a nitrogen-vacancy (NV) center quantum sensing device based on electrohydrodynamic (EHD) printing. A nanopipette with an aperture at one end is filled with nanodiamond suspension ink so the ink is present in a meniscus at The aperture, the nanodiamond suspension ink comprises nanodiamonds and solvent. The nanopipette is supported above a substrate having a back electrode. A DC is applied pulse between the nanopipette and the back electrode so as to generate an electrostatic attractive force resulting in the ejection of nano-diamond-laden droplets with sub-attoliter volume. The droplet lands on the substrate and is allowed to dry due to solvent evaporation. Using the method, the control of the number of printed nano-diamonds is at will, attaining single-particle level precision. This printing approach, therefore, enables printing NV center arrays with a controlled number directly on the substrate without any lithographic process.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• B41J 2/04 - Ink jet characterised by the jet generation process generating single droplets or particles on demand
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• H10B 69/00 - Erasable-and-programmable ROM [EPROM] devices not provided for in groups , e.g. ultraviolet erasable-and-programmable ROM [UVEPROM] devices
• H10N 50/20 - Spin-polarised current-controlled devices

Abstract

A feed composition for spray drying comprises 2-hydroxypropyl-beta-cyclodextrin (2HPβCD), leucine, an anti-IL-4Rα antibody or an antigen binding fragment thereof, and a solvent. A method of preparing a pharmaceutical composition comprises a step of spray drying the feed composition by such as a spray dryer. A pharmaceutical composition comprises or consists of: 2HPβCD, leucine, an anti-IL-4Rα antibody or an antigen-binding fragment thereof. Use of the feed composition according to any of the pharmaceutical composition or according to any of the manufacture of a medicament for preventing or treating a disease, preferably, the disease is one that can be treated by the anti-IL-4R antibody or an antigen binding fragment thereof.

IPC Classes  ?

• A23K 20/163 - Sugars; Polysaccharides
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Probiotic compositions and methods for enhancing efficacy of COVID-19 vaccination or for reducing adverse effects of COVID-19 vaccination.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/741 - Probiotics
• A61K 35/745 - Bifidobacteria
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 37/04 - Immunostimulants

Abstract

Disclosed are methods for constructing disulfide mimetics for late-stage cyclization of peptides. The disclosed method provides late-stage cyclization via thioacetalization of peptides containing two cysteine residues to form thioacetal group. These bonds are stable under acidic, basic, and reduced conditions. The reaction can use a broad range of cyclic ketones even acetone as crosslinkers. Trifluoroacetic acid (TFA) alone can act as both the catalyst and the sole solvent, thus allowing most peptide sequences to be cyclized via the disclosed method. The disclosed method provides a number of benefits and advantages, such as the use of TFA as both a robust catalyst of the reaction and the sole solvent needed, the easy availability of acetone and of diverse cyclic ketones for use as the reactant, the good chemoselectivity and tolerance of native peptide to the reaction, and the fact that the resulting crosslinks are structural mimetics of disulfides.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

Abstract

232222-alkyl, SCHF-alkyl, S-alkyl, S-aryl, etc., onto tryptophan residue (s) of a peptide, in particular a native peptide. Generally, the late-stage peptide modification method includes: (i) maintaining a reaction mixture at a sufficient temperature for a sufficient period of time to form a product. The reaction mixture contains the peptide being modified, which contains one or more tryptophan residues; a sulfynyl reagent; and a solvent. The product formed in step (i) contains a sulfenylated peptide, where the sulfenylation is on at least one of the one or more tryptophan residues of the peptide.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C40B 50/08 - Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support

Abstract

A fusion peptide comprising a coronavirus HR2-derived peptide fused to an ACE2-derived peptide or a lipopeptide comprising the fusion protein and cholesterol is a broad spectrum inhibitor of coronavirus.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/12 - Viral antigens

Abstract

A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is formed from the bone structure data set from step (i) and the implant data set from step (ii), and wherein the mesh-free model of trabecular bone is indicative of the trabecular bone structure of the bone structure at the anatomical site; and (iv) determining a biomechanical result based upon computer simulated loading of the bone-implant system based upon mesh-free analysis of the bone-implant model, wherein the biomechanical result includes data based on the displacement of the implant relative to the bone of bone-implant model.

IPC Classes  ?

• A61F 2/30 - Joints
• G06F 30/20 - Design optimisation, verification or simulation
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A novel medical image generation approach synthesizes thin-cut computerized tomography (CT) images from thick-cut CT ones as inputs. First thick-cut CT images are obtained by maximizing the pixel-wise intensity of five or more than five continuous thin-cut ones after image registration. Second, the obtained thick-cut CT images are fed into a generator block which adopts an encoder-decoder architecture, where each thick-cut image is encoded into low-dimensional embedding space before decoding into multiple thin-cut ones. Third, a discriminator focuses on distinguishing original real thin-cut images from synthetic thin-cut images. An adversarial mechanism between the generator and discriminator causes the discriminator's output to provide an effective gradient update of the network parameters for the generator to increasingly improve the generator's ability to synthesize higher-quality thin-cut images and in turn promotes the discriminator's discriminating capability.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The present invention provides a class of magnetic hydrogels with tissue-mimetic mechanical properties and photothermal welding/healing capability. In these hydrogels, a hybrid network involving aramid nanofibers, functionalized Fe3O4 nanoparticles, and polyvinyl alcohol (PVA) is accomplished by a stepwise assembly of the functional components. The engineered interactions between nanoscale constituents enable facile materials processing and confer a combination of excellent mechanical properties, magnetism, water content and porosity.

IPC Classes  ?

• C08K 9/04 - Ingredients treated with organic substances
• C08K 3/22 - Oxides; Hydroxides of metals
• C08K 7/02 - Fibres or whiskers
• C08L 29/04 - Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• H01F 1/44 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery

Abstract

A portable, miniaturized microfluidic droplet-based digital polymerase chain reaction (PCR) device is provided. The device includes a droplet generation layer with a flow-focusing channel and multiple capillary channels, in which the flow-focusing channel has a flow focusing structure to generate droplets from a provided aqueous sample and extract oil, and the multiple capillary channels is configured to perform an oil extraction. An incubation layer includes heating plates, a microfluidic channel, and a container for conducting a PCR thermal cycling program. Controlled by a controller and powered by a power supplier, the PCR thermal cycling program involves maintaining predefined temperatures on each heating plate sequentially. This process ensures the heating of droplets to different temperatures at distinct times, facilitating precise and efficient PCR amplification.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01L 7/00 - Heating or cooling apparatus; Heat insulating devices

Abstract

Platinum (II) complexes (“Pt(II) complexes”) that can emit in the red and/or deep red regions and methods of making and using thereof are described. These Pt(II) complexes can have dinuclearity with close Pt—Pt contact and close interplanar distance, allowing for high emission quantum yield, such as >50%, short emission lifetime, such as <3 μs, and high radiative decay rate, such as in the order of 105 s−1. The Pt(II) complexes disclosed herein can be included in organic light-emitting devices, such as organic light-emitting diodes (“OLEDs”), for use in commercial applications. OLEDs containing these red-emitting Pt(II) complexes can have current efficiency and/or external quantum efficiency that are comparable or higher than commercially available red emitters and prolonged operational lifetime, such as a LT95 at 1000 nits>9000 h for a red OLED.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants

Abstract

A three dimensional classification system for recognizing cross-sectional images automatically contains a processor that executes: (1) rescaling of a plurality of cross-sectional images; and feeding the rescaled plurality of cross-sectional images into two branches; (2) feeding the rescaled plurality of cross-sectional images into a first branch for performing a plurality of convolutions on the rescaled plurality of cross-sectional images directly to learn features for distinguishing phases; (3) feeding the rescaled plurality of cross-sectional images into a second branch for reducing resolution, and then performing a plurality of convolutions on the reduced resolution plurality of cross-sectional images to learn features for distinguishing phases; and (4) concatenating convolutional output channels from the two branches to fuse global and local features, on which two fully-connected layers are stacked as a classifier to recognize cross-sectional volumetric images accurately and quickly.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 3/40 - Scaling of a whole image or part thereof
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Provided is a cocrystals of remdesivir (RDV) composed of a 1:1 molar ratio of RDV and benzoic acid derivative. The benzoic acid derivative can be salicylic acid (SA). The RDV-SA cocrystal are formed by either liquid-assisted grinding or spray-drying, followed by thermal annealing to facilitate cocrystal formation. The RDV-SA cocrystals can be formulated as inhalable dry powders and included in a medicament for use in treatments for influenza viral infections, such as COVID-19. The inhalable RDV-SA cocrystal dry powders is suitable for deep lung delivery, with good dissolution performance.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/60 - Salicylic acid; Derivatives thereof

Abstract

Disclosed is a system for stabilizing a power distribution network. The network is supplied at least partially by a renewable energy source. The system comprises a bidirectional AC-DC power conversion system between a supply 5 side distribution network and a load side grid. for converting a supply side AC voltage, at a supply side frequency. to a load side DC voltage; a voltage regulator for regulating the load side DC voltage; and a supply side control loop comprising at least one of a frequency control loop and a voltage control loop for making a measurement of a respective one of the supply side frequency and 10 supply side AC voltage. and controlling bidirectional power transmission between the bidirectional AC-DC power conversion system and one or more DC loads connected to the load side grid. based on the measurement from the respective frequency control loop and/or voltage control loop.

IPC Classes  ?

• H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
• H02J 3/16 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by adjustment of reactive power
• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02M 7/797 - Conversion of ac power input into dc power output; Conversion of dc power input into ac power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

The subject invention pertains to a microfluidic pipeline which enables isolation and analysis of single viruses. Single viruses are encapsulated and manipulated within microfluidic droplets. The subject invention further pertains to the amplification of single viral genomes are amplified and confined within the droplets, followed by extraction and isolation of the single-droplet contents for sequencing analysis.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

Disclosed are methods and compositions for use in preparing dynamic biological macromolecules for high-resolution cryo-electron microscopy or cryo-electron tomography imaging. The compositions contain a metallo-supramolecular branched polymer with a positive zeta potential, containing a hydrophilic polymer segment, a chelating chemical group, and a metal ion. The hydrophilic polymer segment is covalently bonded to the chelating chemical group that is in turn bonded to the metal ion via a dative bond. The methods and compositions can be used to improve particle distribution in vitreous ice and/or to change particle orientations in vitreous ice. Accordingly, the methods and compositions can be utilized to improve particle distribution for high resolution structure determination using single-particle cryo-EM.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• G01N 23/225 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes

Abstract

Methods for treating or preventing a skeletal sequelae of a coronavirus infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae can include one or more of arthralgia, viral arthritis, osteopenia, osteochondral damage, and osteoporosis.

IPC Classes  ?

• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 19/00 - Drugs for skeletal disorders
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A method and systems for making predictions based on a classifierare provided. The method includes receiving a multivariate input having feature variables; making prediction based on a comonotone-independence Bayes classifier (CIBer) via performing conditional probability mass function on the feature variables; and outputting a predictive class. The making prediction based on the comonotone-independence Bayes classifier (CIBer) includes a joint encoding to artificially insert ordering in categorical features. The joint encoding is configured to preserve inherent dependence among the categorical features.

IPC Classes  ?

• G06F 18/2415 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate

Abstract

An opto chip for detecting a physical parameter of a liquid sample, comprising an optical structure monolithically integrated with a substrate layer and a functional layer, wherein the substrate layer is light-transmissive and configured to have an upper surface for receiving a droplet of the liquid sample and a lower surface bonded to the functional layer; and the functional layer comprises a light-emitting region and a light-detecting region with the light-emitting region being configured to emit measurement light. The light-detecting region is configured to receive reflected light derived from the measurement light and a signal reflecting the change in intensity thereof is converted into a photocurrent signal. A viscometer and detection method operated using the same opto chip technique. The need for complex external optical calibration is thus eliminated, making the viscometer easier to operate and reducing the overall size of the device.

IPC Classes  ?

• G01N 11/10 - Investigating flow properties of materials, e.g. viscosity or plasticity; Analysing materials by determining flow properties by moving a body within the material

Abstract

Building block structures containing N, O/S-benzylidene acetal dipeptide (NBD) are described. The unique core structure of NBD can effectively convert those difficult peptide/proteins sequence into the easy ones, allowing smooth synthesis of those challenging targets. Further, the production of NBDs is highly robust, and it can be scale up facilely, which can facilitate the research and development of tailor-made peptides/proteins in the future.

IPC Classes  ?

• C07K 1/02 - General processes for the preparation of peptides in solution
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 2/00 - Peptides of undefined number of amino acids; Derivatives thereof

Abstract

A holographic near-eye display device capable of multi-angle simultaneous illumination, comprising a light source module, a spatial light modulator (130), a beam splitter (120), an eyepiece, and a master controller (150). The light source module is used for emitting parallel light of different angles to simultaneously illuminate and cover an effective working region of the spatial light modulator (130). The spatial light modulator (130) is loaded with a hologram and used for modulating incident parallel light of different angles to form diffracted parallel light of different angles, i.e., virtual images of different viewing angles. The parallel light of different angles illuminates the spatial light modulator (130) and is modulated and diffracted via a computer-generated hologram on the spatial light modulator (130), and diffracted image light is converged by a second lens (140) to form different viewpoints for viewing by human eyes. The multi-angle simultaneous illumination does not require additional time-sharing control of an illumination unit, and when the size and position of human eye pupils change, a clear virtual image can always be seen, thereby achieving the objective of expanding an eyebox.

IPC Classes  ?

• G02B 27/01 - Head-up displays
• G03H 1/22 - Processes or apparatus for obtaining an optical image from holograms

Abstract

A process and an apparatus conduct microfluidic loading and unloading of fluids into microchannels for performing assays, such as immunoassays. The apparatus includes a sequential loading and unloading unit having a movable member dipping a chip having a microchannel including a sample into a cartridge retaining a substance to guide the predetermined substance into the microchannel by capillary action to mix the predetermined substance with the sample. A signal detection unit performs an analysis of the mixed sample and generates an analysis message corresponding to the sample. An output device outputs the analysis message. The process implements operation of the apparatus.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Abstract

Engineered guide RNAs having enhanced stability of interaction with Cas enzymes are disclosed. The variant sgRNAs include engineered nucleic acids in or around the stem-loop 2 region which enhance interaction with the Cas9 enzyme and impart enhanced specificity and on-target editing activity. Compositions and methods of engineered guide RNAs are provided for enhanced genomic engineering with increased on-off target specificity and on-target editing efficacy.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Described herein are dinuclear platinum(II) emitter complexes and their methods of making and using thereof. The design of the dinuclear platinum(II) emitters results in short radiative lifetimes and high quantum yields. The dinuclear platinum(II) emitter complexes can be used to fabricate blue emitting OLEDs.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants
• H10K 101/10 - Triplet emission

Abstract

A composite nanofiber aerogel (CNA) is formed from aramid nanofibers (ANFs) combined with polyvinyl alcohol (PVA). These nanoscale constituents of the aerogel form 3D networks with high nodal connectivity and strongly welded connectivity joints between fibrils so that the structure has high stiffness and strength compared to other polymeric aerogels and successive breakage of crosslinks at the connectivity nodes affords energy dissipation while maintaining the overall structural integrity. A specific class of CNA with a specific solid content may be used to form a thin firm with a composite nanofiber framework (CNFF) that is useful in the manufacture of kirigami wearable electronics.

IPC Classes  ?

• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
• C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum

Abstract

Provided is a high throughput screening method for identifying cell fusion or syncytium formation potential. In particular, the cell fusion or syncytium formation potential of a viral spike protein. Also provided is a method for identifying a cellular factor that promotes spike protein-induced syncytium formation. Also provided is a method of inhibiting or suppressing syncytium formation induced by a viral spike protein.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

Described herein are compounds containing palladium(II), as the central metal atom, and tetradentate [N{circumflex over ( )}C{circumflex over ( )}C{circumflex over ( )}N] ligands. The compounds are charge neutral, and feature a donor-acceptor structure where a pendant substituted amino group (such as unsubstituted diphenylamine or substituted diphenylamine) and a heteroaryl group (such as pyridine group) serve as donor and acceptor, respectively. This donor-acceptor structure introduces a set of low-energy singlet and triplet charge-transfer excited states with small energy separation allowing for efficient thermally activated delayed fluorescence to take place.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 85/30 - Coordination compounds
• H10K 101/10 - Triplet emission
• H10K 101/20 - Delayed fluorescence emission
• H10K 102/00 - Constructional details relating to the organic devices covered by this subclass

Abstract

The present invention provides a scalable method for achieving shape control of diamond micro-nanoparticles, comprising air oxidizing diamond micro-nanoparticles grown by chemical vapor deposition and/or diamond micro-nanoparticles grown by high pressure and high temperature. The present invention achieves the controllable morphology transformation of diamond micro-nanoparticles via air oxidation treatment. It has been demonstrated that a series of unique shapes, including “flower” shaped, “hollow” structured, “pyramid” patterned on the surface, and “boomerang” shaped, can be achieved by altering the air oxidation parameters, i.e., temperature and duration. The scalable production of these differently shaped diamond micro-nanoparticles represents a significant scientific breakthrough together with a high commercial value. The ability to produce diamond particles with desired shapes simply and cost-effectively will remove many obstacles to using diamonds for practical applications in nanophotonics, quantum computing, quantum optics, etc.

IPC Classes  ?

• C23C 16/44 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating
• C23C 16/02 - Pretreatment of the material to be coated
• C23C 16/27 - Diamond only
• C23C 16/511 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating using electric discharges using microwave discharges
• C23C 16/56 - After-treatment

Abstract

A method of treating a coronavirus infection in a subject in need thereof, the method including administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/513 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A method for printing electronic components is based on the hybridization of Fused Deposition Modeling (FDM) and laser sintering. The method involves printing a layer of composite copper-based thermoplastic filament on a base. Then the filament is subjected to a laser beam so as to selectively remove the polymer matrix in a restricted area after printing to leave only the conductive particles forming a highly conductive network and sintering the conductive particles with the laser energy to reveal the conductive copper. Then, alternately repeating the printing and sintering steps on the filaments one on top of the other until a complete component of arbitrary geometry, including both insulative and conductive structures, is formed layer-by-layer.

IPC Classes  ?

• B22F 10/18 - Formation of a green body by mixing binder with metal in filament form, e.g. fused filament fabrication [FFF]
• B22F 10/20 - Direct sintering or melting
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B29C 64/194 - Processes of additive manufacturing involving additional operations performed on the added layers, e.g. smoothing, grinding or thickness control during lay-up
• B29C 64/371 - Conditioning of environment using an environment other than air, e.g. inert gas
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials

Abstract

A small volume optoelectronic chip contains an LED chip with a diamond having nitrogen-vacancy centers embedded therein. The LED chip generates light having a first wavelength, and the diamond with nitrogen-vacancy centers generates light having a second wavelength after excitement with light having the first wavelength. The diamond may also be on or adjacent the LED.

IPC Classes  ?

• G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
• H01L 33/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies
• H01L 33/04 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction

Abstract

The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Disclosed is a computer-implemented three-dimensional image classification system (CIS) for processing and/or analyzing non-contrast computed tomography (CT) medical imaging data. The CIS is a deep neural network containing multiple Convolutional Block Attention Module (CBAM) blocks, which contain convolutional layers for feature extraction followed by CBAMs. The CBAM applies channel attention to highlight more relevant features and spatial attention to focus on more important regions. Max pooling layers operably link adjacent pairs of CBAM blocks. The output of the final CBAM block is passed to two terminal fully connected layers to generate a diagnosis. This classification system can be used to perform efficient diagnosis of hepatocellular carcinoma using solely non-contrast CT images, with diagnostic performance comparable to that of a radiologist using the current LIRADS system.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
• A61B 6/03 - Computerised tomographs
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/50 - Context or environment of the image
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Described are multi-resonance-thermally-activated delay-fluorescence compounds containing (i) a polycyclic aromatic/heteroaromatic ligand in which a plurality aromatic/heteroaromatic rings are linked by boron and nitrogen atoms and (ii) an N-heterocyclic carbene ligand, with both ligands coordinated to a metal atom/ion that has a high spin-orbit coupling. The use of the high spin-orbit coupling of metals and/or metal ions facilitates the intersystem crossing and/or reversed intersystem crossing processes of MR-TADF emitters, thereby largely accelerating the rate of TADF and substantially shortening the lifetime of deleterious triplet excitons. The MR-TADF emitters can be used to fabricate blue to green emitting OLEDs.

IPC Classes  ?

• C07F 1/12 - Gold compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 85/30 - Coordination compounds
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Sequences for detection of SARS-CoV-2 are provided and include example, SEQ ID NOs:4-8. The sequences are useful for amplifying the SARS-CoV-2 nsp8 gene in a sample, using Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) and it is preferably used in combination with a Cas enzyme/sgRNA pair and a reporter nucleic acid. Sequences for detection of SARS-CoV-2 are provided and include example, SEQ ID NOs:4-8. The sequences are useful for amplifying the SARS-CoV-2 nsp8 gene in a sample, using Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) and it is preferably used in combination with a Cas enzyme/sgRNA pair and a reporter nucleic acid. The disclosed sequences can be use in methods of detecting SARS-CoV-2 nucleic acids in a sample. Generally, the specific gene sequence of SARS-CoV-2 RNA, herein nsp8, is amplified using RT-LAMP. The RT-LAMP products are scanned by the Cas12a-gRNA ribonucleoprotein (RNP) complex. The RNP binds to the specific complementary to gRNA, activating the transcleavage activity of Cas12a. The active Cas12a system cleaves a short ssDNA reporter that is labeled preferably, with a fluorophore and a quencher on either end. Cleavage of the reporter separates the quencher from the fluorophore, and fluorescence that is detectable with the naked eye is generated.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

A steerable arm for use in endoscopic surgical procedures. The steerable arm cut from a tube of nitinol to provide flexibility and resilience by the structure into which the tube is cut. Typically, the cut tube comprises a spiralling coil, the loops of which are in contact on one lateral side of the tube and the tube is bent to open apart the loops on the other lateral side. The material which the tube is made of is capable of retaining memory of the bend. This provides a bias for restoring the tube to the bend whenever a force causing the tube to flex is removed.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery

Abstract

Live attenuated viruses for protection against the novel coronavirus Sars-CoV-2 are provided. The live attenuated chimeric virus strains are based on a live attenuated influenza A or B virus (LAIVA/B), used a master backbone, which includes deletion of the viral virulence element, the NS1 (non-structural protein 1) (DeLNS1), engineered to express one or more antigens of the Sars-CoV-2 (herein, CoV2Ag). The chimeric virus strain is referred to generally herein, as DelNS1-A/B-Sars-CoV-2-CoV2Ag. The DelNS1-A/B-Sars-CoV-2-CoV2Ag strain preferably shows spontaneous cold adaption with preference to grow at 30-33° C. Compositions including the chimeric virus also provided as a co-composition with a LAIVA/B. The DelNS1-A/B-Sars-CoV-2-CoV2Ag strain can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2. The co-compositions can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2 and influenza A and/or B.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention provides a diamond particle-based physical unclonable function material, and a preparation method therefor and a use thereof. The material comprises a monocrystalline silicon substrate, and diamond particles having silicon vacancy color centers and grown in situ on the monocrystalline silicon substrate. Preparation of the diamond particles on the silicon substrate relates to a random process, which is a key requirement for manufacturing a physical unclonable function label. According to the present invention, the scattering spectra, morphology features and spatial position relationship of the diamond particles are used as fingerprint information of the diamond physical unclonable function material. Due to extreme heat resistance, mechanical, chemical and light stabilities of a diamond material, the high-robustness label in the present invention can meet the requirements of many practical uses in various environments, and has practical commercial value in huge anti-counterfeit markets such as electronic components, medical packages, vehicles, and luxury goods.

IPC Classes  ?

• C09K 11/65 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing carbon
• C23C 16/27 - Diamond only
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Provided is a robust nasal organoid culture system and fully characterized 2D and 3D in-vitro generated organoids, and methods of using the organoids. The nasal organoids contain a population of differentiated nasal epithelial cells having cellular heterogeneity and molecular markers similar to mature nasal epithelial tissue. Improved methods for generating two-dimensional and three-dimensional nasal organoids are also provided. The methods generally require a two-phase culture system, i.e., expansion and differentiation culture. The provided nasal organoids are suitable for recapitulating nasal tissue complexity for modeling respiratory diseases, studying barrier function and drug delivery, high-throughput drug screening, and assessing the effects of pathogens and environmental toxins on the nasal respiratory epithelium.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/36 - Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells

Abstract

A rechargeable aqueous Mg battery is composed of a Mg metal anode, a solid-state aqueous polymer-based electrolyte, and an intercalation-type Prussian blue analogue cathode for ion storage. During battery operation, the Mg anode undergoes dissolution and deposition, while Mg ions in the electrolyte inserts and extracts from the cathode lattice, thereby releasing energy during discharge and storing energy during charge.

IPC Classes  ?

• H01M 10/36 - Accumulators not provided for in groups
• H01M 10/38 - Construction or manufacture

Abstract

The subject invention pertains to a new method for measuring the elastic properties of microfibers by rope-coiling. Rope-coiling refers to the buckling of a slender elastic fiber caused by axial compression. A continuous flow microfluidic method enables the high-throughput measurement of the elasticity of microfibers by rope-coiling, where sample loading and unloading are not needed between consecutive measurements. In certain embodiments the coiling radius can be directly proportional to the elastic modulus of the fiber, facilitating calibration to measure fiber elasticity for high-throughput applications. Throughput can be thousands of times higher than that of a tensile tester, making possible an in situ, on-line measurement in a microfluidic production line, which couples the making of microfibers and the measurement of elasticity on the same line. The new method can also measure certain fibers with local variations in elasticity.

IPC Classes  ?

• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces

Abstract

Genetically modified zebrafish, in which mutation combinations frequently identified in human AML are stably expressed in the stem cell population of the fish, are provided. The combination of mutations result in morphologic, cytochemical and molecular changes of its blood cells that are remarkably similar to those in human AML. The zebrafish model provides a foundation for the study of AML initiation and progression and a high throughput in vivo drug screening platform to identify personalized therapies for AML based on specific mutation combinations. The method of drug screening includes contacting embryos or adult fish containing mutations as disclosed herein, with a test agent, at test concentrations and test intervals to determine the therapeutic effect if any, of the test agent.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A01K 67/027 - New breeds of vertebrates
• A61K 49/00 - Preparations for testing in vivo

Abstract

The invention relates to the field of biomedicine. In particular, the invention relates to a live strain of Staphylococcus aureus and uses thereof. More particularly, the invention relates to a live strain of Staphylococcus aureus which lacks adenosine synthase A (AdsA) activity, to a vaccine against Staphylococcus aureus infection comprising said live strain, and a method for preventing and/or treating Staphylococcus aureus infection in a subject by administering said live strain.

IPC Classes  ?

• A61K 39/085 - Staphylococcus
• C12N 1/36 - Adaptation or attenuation of cells
• C12N 1/20 - Bacteria; Culture media therefor

Abstract

The subject invention pertains to a system for the electrochemical conversion of nitrate to ammonia. The electrolysis is carried out using a cell with a working electrode having a CuDATA molecular catalyst absorbed on carbon black. The system is effective for the conversion of waste nitrate solutions to ammonia. The conversion occurs with a high faraday efficiency of about 98%.

IPC Classes  ?

• C25B 1/27 - Ammonia
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds

Abstract

Disclosed are methods of purifying nanodiamonds and a method of making essentially pure nanodiamonds each involving mixing nanodiamonds with at least one salt to form a mixture; heating the mixture at a temperature from 200° C. to 1,000° C. for a time from 10 minutes to 10 hours; and combining a liquid with the heated mixture and centrifuging at a speed of 30 rcf to 25,000 rcf for a time from 10 seconds to 60 minutes to provide purified nanodiamonds. With the methods of the invention, pure NDs can be produced by one-step processing after air oxidation, without the need for any further centrifugation acts. Furthermore, the developed salt-assisted air oxidation method enables facile scale-up manufacturing of clean NDs, with a rounded shape transformed from original shard-like shape, which is impossible to achieve using any existing purification method.

IPC Classes  ?

• C01B 32/28 - After-treatment, e.g. purification, irradiation, separation or recovery

Abstract

The subject invention pertains to cocrystals of dexamethasone (DEX) and a benzenediol cocrystal composed of a 1:1 molar ratio of DEX and the benzenediol. The benzenediol can be catechol (CAT) or resorcinol (RES). The DEX and benzenediol cocrystal are formed by grinding crystalline DEX where the crystalline benzenediol are combined in the 1:1 molar ratio. Grinding can be performed at room temperature. Cocrystals can be thermally annealed or exposed to humidity to enhance cocrystal formation. The DEX−CAT or DEX-RES cocrystals can be included in a medicament for use in treatments for allergies, asthma, rhinitis, cancer, diabetes, anemia, ulcers, and viral infections. The DEX−benzenediol cocrystal can be sieved to provide particles that are in the range of 10 to 45 μm that can be used for intranasal administration with improved dissolution performance.

IPC Classes  ?

• C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• C07C 37/84 - Separation; Purification; Stabilisation; Use of additives by physical treatment by crystallisation
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

A nano scale robotic system for single cell DNA sequencing of a strand of DNA positioned on a slide utilizes an atomic force microscope (AFM) having an end effector in the form of a cantilever with a tip. The AFM causes its cantilever tip to scan over the base pairs of the DNA strand. A pair of spaced-apart electrodes at the tip makes contact with opposite sides of the DNA strand and the current between bases of the DNA strand is measured by a current measurement system connected to the electrodes. An artificial intelligence-based data analytic system determines the DNA sequence based on the current from the current measuring system. The AFM tip is guided over the DNA strand by comparing compressed desired intensity local scan images and compressed actual intensity local scan images and using the difference to control the location of the tip.

IPC Classes  ?

• G01Q 30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope
• C12Q 1/6869 - Methods for sequencing
• C23C 14/16 - Metallic material, boron or silicon on metallic substrates or on substrates of boron or silicon
• C23C 14/30 - Vacuum evaporation by wave energy or particle radiation by electron bombardment
• C23C 14/34 - Sputtering
• C23C 14/58 - After-treatment
• C23C 16/04 - Coating on selected surface areas, e.g. using masks
• C23C 16/40 - Oxides
• C23C 16/56 - After-treatment
• G01Q 20/02 - Monitoring the movement or position of the probe by optical means
• G01Q 30/20 - Sample handling devices or methods
• G01Q 60/38 - Probes, their manufacture or their related instrumentation, e.g. holders
• G01Q 70/16 - Probe manufacture
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
• G16B 40/20 - Supervised data analysis

Abstract

The subject invention pertains to a Cas9 protein with an amino acid mutation at residues 888, 889, or a combination thereof of a WED domain and/or residues 988, 989, or a combination thereof of a PI domain. The subject invention can further pertain to a Cas9 protein with mutations at amino acid positions N986, D987, L988, L989, or any combination thereof. The subject invention also pertains to a method of enhancing the activity of KKH-SaCas9. In addition, a method of machine learning-based in silico screens for genome editing protein engineering is provided, including steps of populating a predictive machine learning model with an input dataset comprising empirical measurements of on-target activities of sgRNAs paired with a screening library of genome editing enzyme variants; running the predictive machine learning model with predefined parameters; and evaluating performance of the predictive machine learning model.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 9/22 - Ribonucleases

Abstract

Disclosed is a method of obtaining preparing an extract of Spatholobus suberectus Dunn, which contains total flavonoid and proanthocyanidins. The disclosure relates to a method for extracting an active fraction from Spatholobus suberectus. Also provided is the SSP, the active fraction, and a composition thereof. Further provided is a method of treating viral diseases such as COVID-19 disease caused by SARS-CoV-2, and use of the SSP and the active fraction in the manufacture of preparations for prevention and/or treatment of a viral disease.

IPC Classes  ?

• A61K 36/486 - Millettia
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 31/12 - Antivirals

Abstract

Disclosed is a flexible battery made of a cathode comprising printable graphite, the cathode positioned on a first side of a paper; an anode comprising aluminum on a second side of the paper; an aqueous electrolyte comprising water and an aluminum halide, the aqueous electrolyte saturated within the paper; and an encapsulating film surrounding the anode and cathode.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/46 - Alloys based on magnesium or aluminium
• H01M 10/38 - Construction or manufacture

Abstract

Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

IPC Classes  ?

• C07D 295/08 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07D 215/58 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
• C07D 217/06 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
• A61P 31/04 - Antibacterial agents

Abstract

Synthetic agrimol B and derivatives thereof ( "compounds" ) that have anticancer properties are disclosed. Methods for synthesizing the compounds with an overall yield ≥ 7% are disclosed. Pharmaceutical formulations in forms suitable for the delivery of the compounds to a subject in need thereof are disclosed. Methods of using the compounds for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer, such as non-small-cell lung cancer, in a subject are also disclosed. The methods include (i) administering to the subject the pharmaceutical formulation containing one or more compounds, for one or more times. The compounds can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by inducing mitochondria dysfunction and/or inhibiting ER to Golgi trafficking in the cancer cells and/or cancer stem cells.

IPC Classes  ?

• C07C 49/84 - Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
• C07C 49/83 - Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
• C07C 45/45 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
• C07C 45/61 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of C=O groups
• A61K 31/12 - Ketones
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed in the present invention are benzothiazole compounds as well as a preparation method therefor and the use thereof. The compounds have a great inhibition effect on SARS-CoV-2 and can be used for resisting the novel coronavirus. (I)

IPC Classes  ?

• C07D 277/66 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The subject invention pertains to compounds and methods of using said compounds to target the multi-functional papain-like protease (PLpro) domain of the viral Nsp3, specifically F0213, F0326, and F0393 that can have broad anti-coronavirus activity, including SARS-CoV-2, MERS-CoV, and coronaviruses hCoV-229E and hCoV-OC43. F0213, F0326, and F0393 can possess a dual therapeutic functionality that suppress CoV replication via blocking viral polyprotein cleavage, as well as promote antiviral immunity by antagonizing the PLpro deubiquitinase activity.

IPC Classes  ?

• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 31/14 - Antivirals for RNA viruses
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

Provided are engineered, replication-deficient influenza viruses that are infectious and stimulate broadly-cross protective immunity against multiple different influenza strains. Also provided are compositions and methods for providing protective immune responses against influenza. The methods deliver compositions of intact, replication-deficient influenza viruses by intradermal administration in an amount effective to elicit or stimulate a cross-protective immune response to influenza viruses in the recipient following a single administration. Because the engineered influenza viruses are non-replicating, they are safe and effective in immunocompromised subjects. Also provided are methods for delivering co-stimulatory molecules, growth factors, adjuvants and/ or cytokines together with the non-replicating influenza viruses.

IPC Classes  ?

• C12N 7/04 - Inactivation or attenuation; Producing viral sub-units
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

Methods for asymmetric cis-dihydroxylation (“AD”) of quinones to produce cis-diols of quinones with high yield (i.e. a yield ≥30%) and high enantioselectivity (i.e. an enantiometric excess ≥30%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst, and can be performed under mild reaction conditions (e.g. a temperature ≤50° C. at 1 atom in open air). The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a quinone, one or more iron-based catalyst(s), and a solvent, and where the product contains a chiral cis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.

IPC Classes  ?

• C07C 50/04 - Benzoquinones, i.e. C6H4O2
• C07C 50/30 - Quinones containing groups having oxygen atoms singly bound to carbon atoms with polycyclic non-condensed quinoid structure
• C07C 50/12 - Naphthoquinones, i.e. C10H6O2
• C07C 50/36 - Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
• C07C 50/34 - Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having three rings
• B01J 31/40 - Regeneration or reactivation

Abstract

ciscisciscis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.

IPC Classes  ?

• C07C 29/48 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
• C07C 35/14 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing six-membered rings with more than one hydroxy group bound to the ring
• B01J 31/28 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of the platinum group metals, iron group metals or copper

Abstract

It has been established that CD55 expression on human mesenchymal stem cells (hMSCs) is positively correlated with successful allogenic transplantation procedures. Compositions and methods for improved hMSCs, having increased expression of CD55 mRNA and/or increased expression of CD55 on the surface of the cell as compared to a control cell, are provided. Methods include isolating hMSCs from a tissue that naturally has increased CD55 expression, such as adipose tissue derived hMSC (AT-hMSC); and/or in vitro culturing hMSCs in the presence of one or more active agents that stimulates or enhances the expression of CD55 mRNA, and/or increases the surface expression of CD55 in the hMSC to provide improved hMSCs. Preferred active agents include HMG-CoA reductase inhibitors such as atorvastatin and EGFR inhibitors such as erlotinib. Compositions and methods for administering the improved hMSCs to a subject in need thereof are also provided.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/517 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

Antiviral peptides and formulations thereof are described for use in treating or preventing one or more symptoms of coronavirus infections. Peptides derived from human beta defensin 2 have been shown to have antiviral properties against different variants of coronavirus including cross-linking viral particles, blocking cell-to-cell fusion, and/or inhibiting viral release. Pharmaceutical compositions and methods of using one or more antiviral peptides are also provided. Preferably, the antiviral peptides are administered via intranasal route to prevent or alleviate one or more symptoms of coronavirus infections such as reducing the syncytial formation and lung damage.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 33/06 - Antimalarials

Abstract

Disclosed are compositions and methods using antibodies and antibody fragments that bind SARS-CoV-2 spike protein or receptor binding domain (RBD). Generally, the CDRs of the antibodies and antigen binding fragments comprise: (a) the three light chain CDRs selected from the group consisting of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, and 64; and (b) the three light chain CDRs selected from the group consisting of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, and 63.In some forms, the antibody is a bispecific antibody.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/42 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Provided are a composition comprising a peptide conjugated to a TLR agonist, including TLR7 agonist 1v209, and methods of using the composition. The methods comprise administering the peptide-based vaccine conjugate to a subject. The peptide-based vaccine conjugate inhibits tumor growth and induces antigen-specific B and T cell responses in a subject.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 35/00 - Antineoplastic agents

Abstract

An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950/1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50/50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.

IPC Classes  ?

• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• H01S 3/067 - Fibre lasers
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/16 - Solid materials
• H01S 3/108 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using non-linear optical devices, e.g. exhibiting Brillouin or Raman scattering
• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
• H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
• H03F 3/19 - High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only
• G01N 33/483 - Physical analysis of biological material

Abstract

Compositions and immunoassays for detecting SARS-CoV-2 antigen-specific antibodies in a biological sample are provided. The compositions are antigens from SARS-CoV-2 such as the proteins N, M, S, S1, S2′, NSP1, ORF3a, ORF3b, ORF7a, ORF7b and ORF8, fused to a light emitting protein. The compositions are useful in immunoassays for detecting antibodies to the SARS-CoV-2 antigens. A preferred immunoassay is the luciferase immunoprecipitation systems (LIPS) to detect SARS-CoV-2 antigen-specific antibodies with high sensitivity and specificity. The current or present exposure or infection with SARS-CoV-2 can be detected and/or diagnosed using the disclosed compositions and methods. Typically, the presence and/or elevated amount of SARS-CoV-2 antibodies in the individual’s biological sample compared to a control is indicative of current or past exposure or infection with SARS-CoV-2 as discussed herein.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A method and system for encrypting and decrypting authentication information about a synthetic Raman diamond tag formed with predetermined defects, impurities and/or strains in its crystal structure. A sender uses an optical spectrometer to establishing authentication identities of the synthetic diamond Raman tag and the sender's nature by means of Raman scanning. The sender then encrypts information about the synthetic Raman diamond tag and the sender, and transfers the Raman tag physically to a receiver and the encrypted information electronically to the receiver. The receiver first authenticates the diamond Raman tag and second authenticates the sender's nature. The receiver decrypts the encrypted information by reverse Raman scanning only if the first and second authenticating steps are successful.

IPC Classes  ?

• G01N 21/87 - Investigating jewels
• G01N 21/65 - Raman scattering

Abstract

Disclosed is a compact, lightweight hydraulic manipulation system used for underwater applications consisting of two parts: a modulus hybrid underwater manipulator and a compact lightweight hydraulic control framework. The system is used for general underwater work such as underwater sampling, hyperbaric welding, and marine aquaculture.

IPC Classes  ?

• B63G 8/00 - Underwater vessels, e.g. submarines
• B25J 15/08 - Gripping heads having finger members
• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
• B63C 11/52 - Tools specially adapted for working underwater, not otherwise provided for
• B25J 15/00 - Gripping heads

Abstract

Described herein are two-coordinated d10 metal carbene complexes containing (i) Cu (I), Ag (I), or Au (I), (ii) a pyrazine-fused NHC ligand or a pyridine-fused NHC ligand, and (iii) a carbazole ligand, a pyrido [2, 3-b] indole ligand, or a pyrido [3, 4-b] indole ligand. The radiative properties of the compounds can be controlled by thermally activated delayed fluorescence. The emission colors of the complexes can be tuned by using carbazoles with varying donor strength. Also described are methods of using the complexes.

IPC Classes  ?

• C07F 1/08 - Copper compounds

Abstract

Disclosed are soft origami actuators with embedded optical waveguides and underwater manipulator applications.

IPC Classes  ?

• B63C 11/52 - Tools specially adapted for working underwater, not otherwise provided for
• B25J 19/02 - Sensing devices
• B25J 15/00 - Gripping heads

Abstract

Described herein are two-coordinated d10 metal carbene complexes containing (i) Cu(I), Ag(I), or Au(I), (ii) a pyrazine-fused NHC ligand or a pyridine-fused NHC ligand, and (iii) a carbazole ligand, a pyrido[2,3-b]indole ligand, or a pyrido[3,4-b]indole ligand. The radiative properties of the compounds can be controlled by thermally activated delayed fluorescence. The emission colors of the complexes can be tuned by using carbazoles with varying donor strength. Also described are methods of using the complexes.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 1/08 - Copper compounds
• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic System
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

The disclosure relates to defective interfering genes and viruses thereof. It has been discovered that defective interfering genes designed from influenza and coronavirus species can inhibit infection or replication of the parent virus. In vivo, DIGs induce rapid-onset prophylactic protection of infected animals against lethal viral doses. Thus, disclosed herein are nucleic acids containing DIGs, pharmaceutical compositions thereof and associated methods of use. For example, described herein is an isolated polynucleotide containing one or more defective interfering genes, wherein each of the one or more defective interfering genes contains a nucleotide sequence corresponding to one or more portions of an influenza or coronavirus gene or genome, wherein the nucleotide sequence includes a deletion in the gene. The DIGs can be in the form of a plasmid. Pharmaceutical compositions of the plasmid can be used to limit viral replication and prevent or treat influenza or coronavirus associated diseases.

IPC Classes  ?

• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

The present invention provides an antibacterial and antiviral copper-containing stainless steel, and a preparation method for and the use of a stainless steel conforming to the composition thereof. The copper-containing stainless steel comprises a stainless steel matrix and a copper-rich phase evenly distributed in the stainless steel matrix, wherein the copper content of the copper-containing stainless steel is 6-30 wt%. The preparation method therefor comprises the manufacturing of a small stainless steel product mainly using powder metallurgy technology, and the manufacturing of a large stainless steel sheet, bar or pipe mainly using a composite process without significant thermal deformation. Compared with a traditional antibacterial stainless steel, the composition design of the present invention contains sufficient copper-rich precipitated phases, such that the antibacterial and antiviral copper-containing stainless steel of the present invention can achieve both a good killing effect on bacteria and a virus killing capacity comparable with that of pure copper, can be used for preparing the integral body or the whole of parts such as cutters, elevator buttons, railings, handrails, door handles and cups, and can effectively kill bacteria and viruses existing on the surfaces thereof.

IPC Classes  ?

• C22C 38/16 - Ferrous alloys, e.g. steel alloys containing copper
• C22C 38/18 - Ferrous alloys, e.g. steel alloys containing chromium
• C22C 38/20 - Ferrous alloys, e.g. steel alloys containing chromium with copper
• C22C 38/38 - Ferrous alloys, e.g. steel alloys containing chromium with more than 1.5% by weight of manganese
• C22C 38/54 - Ferrous alloys, e.g. steel alloys containing chromium with nickel with boron

Abstract

Provided are two fully humanized Δ42PD1-specific mAbs, specifically huCH101 and huCH34 at 97.0% humanness by CDR grafting. Provided is a method of using huCH101 and/or huCH34 to treat subjects in need of Δ42PD1-specific mAb, including subjects with cancer and/or infection.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• C12N 15/13 - Immunoglobulins

Abstract

Probiotic compositions and methods for enhancing efficacy of COVID-19 vaccination or for reducing adverse effects of COVID-19 vaccination.

IPC Classes  ?

• A61P 31/12 - Antivirals
• A61K 35/745 - Bifidobacteria
• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 35/741 - Probiotics
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics

Abstract

A UV based surface disinfection system that consists of the UV light source, a robot arm, and an omni directional mobile base. The mobile robot can be programmed autonomously and be able to bring the UV light source to the centimeters away from surfaces to achieve effective and efficient surface disinfection. The mobile robot can navigate autonomously in a complicated environment to perform disinfection operation in a large area.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 11/00 - Manipulators not otherwise provided for
• B25J 5/00 - Manipulators mounted on wheels or on carriages
• B25J 13/00 - Controls for manipulators
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B25J 19/02 - Sensing devices
• A61L 2/24 - Apparatus using programmed or automatic operation
• A61L 2/10 - Ultraviolet radiation

Abstract

The present invention relates to a compound for treating fungal disease, wherein said compound provide target-specific inhibition of fungal adhesion, biofilm formation, and filamentation without affecting their growth, at very low concentration. The compound of the present invention is selected from FDA approved drugs Cangrelor. Further, the present invention provides a composition comprising compound of the present invention and a pharmaceutically acceptable carrier. Further, the present invention provides a method of treating fungal infections using the compound and/or composition of the present invention. Furthermore, uses of the compound and/or composition is also being provided in the present disclosure.

IPC Classes  ?

• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.

IPC Classes  ?

• C07D 207/06 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
• B01J 31/22 - Organic complexes
• C07D 207/12 - Oxygen or sulfur atoms
• C07D 207/14 - Nitrogen atoms not forming part of a nitro radical
• C07D 217/26 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• C07D 221/22 - Bridged ring systems
• C07D 223/18 - Dibenzazepines; Hydrogenated dibenzazepines
• C07D 233/32 - One oxygen atom
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 471/04 - Ortho-condensed systems
• C07D 487/04 - Ortho-condensed systems
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings

Abstract

Disclosed are compositions and methods useful for management of rhinological, neurological, or psychiatric complaints and disorders. The rhinological, neurological, or psychiatric complaint and disorder can be one that affects the normal human neurosensory, neurocognitive, or neuropsychiatric functions, including but not limited to olfactory dysfunction. The complaint or disorder can be one that is related to coronavirus disease 2019 (COVID-19), including but not limited to olfactory dysfunction. Disclosed are compositions including a vitamin A solution and an essential oil mixture. The vitamin A solution can be a vitamin A compound and a nontoxic solvent, such as a pharmaceutically acceptable solvent. The vitamin A compound can be at a concentration of from 10,000 to 120,000 international units (IU). The vitamin A solution and the essential oil mixture can be in a ratio of from 4: 1 to 1: 4 in the composition. The composition of vitamin A solution and essential oil mixture can be aerosolized and administered via the subject's nose.

IPC Classes  ?

• A61K 31/07 - Retinol compounds, e.g. vitamin A
• A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• A61K 9/12 - Aerosols; Foams
• A61K 9/08 - Solutions
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The subject invention pertains to methods and compositions for treating hypertension. In specific embodiments, the methods comprise administering KSD179019 to a subject in need of hypertension treatment. In further embodiments, the methods comprise administering a KSD179019 analog or derivative to a subject in need of hypertension treatment. Also provided are methods to design and manufacture KSD179019 analogs and derivatives with enhanced and prolonged anti-hypertensive therapeutic efficacy.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 9/12 - Antihypertensives

Abstract

Provided herein is DNA vaccine and composition comprising PD1-based TWIST1. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine and an immune checkpoint inhibitor.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents

Abstract

Live attenuated viruses for protection against the novel coronavirus, designated as Sars-CoV-2 by the World Health Organization (WHO) are provided. The live attenuated chimeric virus strains are based on a live attenuated influenza B virus (LAIVB), used a master backbone, which includes deletion of the viral virulence element, the NS1 (non-structural protein 1) (DeLNS1-B), engineered to express one or more antigens of the Sars-CoV-2 (herein, CoV2Ag). The chimeric virus strain is referred to generally herein, as DelNS1-B-Sars-CoV-2-CoV2Ag. The DelNS1-B-Sars-CoV-2-CoV2Ag strain preferably shows spontaneous cold adaption with preference to grow at 30-33° C. The DelNS1-B-Sars-CoV-2-CoV2Ag strain can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2. DelNS1-B-Sars-CoV-2-CoV2Ag is an important strategy for making highly attenuated and immunogenic live attenuated vaccines with the ability to induce protective immunity against Sars-CoV-2.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12N 7/04 - Inactivation or attenuation; Producing viral sub-units
• A61K 35/76 - Viruses; Subviral particles; Bacteriophages
• C12N 15/86 - Viral vectors
• C12N 7/06 - Inactivation or attenuation; Producing viral sub-units by chemical treatment

Abstract

Embodiments of the present invention provide a video timing motion nomination generation system and a method, which process, by means of an encoder, video features that are extracted from an inputted video so as to obtain video encoding features having global information, and extract corresponding segment features of interest from the video encoding features by means of a plurality of pre-trained nomination segments to provide to a decoder; the decoder generates segment features on the basis of the segment feature of interest corresponding to each nomination segment and a nomination feature corresponding to each pre-trained nomination segment, and provides same to a prediction module; and the prediction module generates a timing motion nomination result on the basis of the segment features from the decoder. The solution of the embodiments of the present invention can effectively capture global context information of a video and obtain video encoding features that have a stronger representation ability. Moreover, by introducing several learnable nomination segments to extract feature sequences of corresponding positions from the video encoding features for subsequent prediction, which improves training convergence speed and greatly reduces computational burden.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

An entry/exit detection apparatus has two separate signal transmitters (T1,T2) with a signal blocking device (SBD) in-between them. Based on this apparatus, a virtual line (16) is established for detecting whether an object or a person (A) crossed the virtual line (16) and entered or exited from a place or vehicle which has the virtual line (16) at its entrance. The place may be a building, market, shop, restaurant, bank, school, lift (elevator), room, or car. When the object or person (A) with the portable device crosses this virtual line, the motion is detected by the detector monitoring signal from the two transmitters. The portable device will be able to detect and recognize it has crossed the virtual line automatically based on the signals received from these two signal transmitters.

IPC Classes  ?

• G07C 9/00 - Individual registration on entry or exit

Abstract

Methods for obtaining a population of differentiated alveolar cells, differentiated alveolar cells in the form of alveolar organoids generated by the methods and uses for the differentiated alveolar organoids are provided. The methods include digesting long-term expanding lung organoids (LO) into single cells (i.e., dissociated cells), and suspension culturing the dissociated cells in distal differentiation (DD) cell culture media in a non-adherent plate for an effective amount of time. Alveolar organoids includes a population of AT1 and AT2 cells and in suspension culture exhibit an apical-out polarity and include abundant cytoplasmic lamellar bodies and microvilli. The alveolar organoids can be utilized alone or in combination with 2D and 3D AWO, rebuilt the human respiratory epithelium in culture plates for studying biology and pathology of human respiratory system, including, but not limited to, the study of COVID-19 respiratory diseases.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/42 - Respiratory system, e.g. lungs, bronchi or lung cells
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.

IPC Classes  ?

• C07H 5/06 - Aminosugars
• A61K 31/7008 - Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• A61K 39/02 - Bacterial antigens
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides a video action detection method based on an end-to-end framework, and an electronic device. The end-to-end framework comprises a backbone network, a positioning module, and a classification module. The method comprises: performing, by the backbone network, feature extraction on a video clip to be detected to obtain a video feature map of said video clip, wherein the video feature map comprises feature maps of all frames in said video clip; extracting the feature map of a key frame from the video feature map by the backbone network, obtaining an actor location feature from the feature map of the key frame, and obtaining an action category feature from the video feature map; determining an actor location by the positioning module according to the actor location feature; and determining, by the classification module, the action category corresponding to the actor location according to the action category feature and the actor location. The video action detection method provided by the present invention is relatively low in complexity, and can achieve better detection performance.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

Disclosed are deep learning based methods for magnetic resonance imaging (MRI) image reconstruction from partial Fourier-space (i.e., k-space) data, involving: obtaining high-quality complex MRI image data or fully-sampled k-space data as training data; training reconstruction models to predict high-quality complex MRI image data or complete k-space data from incomplete or partial k-space data; and applying trained models to reconstruct high-quality complex MRI image data or complete k-space data from partial k-space data.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

Disclosed is a fiber-based hydrogel containing an aqueous hydrogel containing biocompatible microfibers having a high aspect ratio length to diameter suspended in water, the biocompatible microfibers mechanically interlocked. By simply adjusting the fiber aspect ratio, the fiber-based hydrogels can tune a considerable range of mechanical properties and drug release rates for clinical use. The fiber-based hydrogel has favorable biocompatibility and accelerated tissue regeneration ability demonstrated by a mice excision skin model.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices

Abstract

Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• C07D 295/26 - Sulfur atoms
• C07D 317/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61P 31/04 - Antibacterial agents
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/18 - Sulfonamides
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4402 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61K 31/4406 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/47 - Quinolines; Isoquinolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene

Abstract

A novel medical image generation approach synthesizes thin-cut computerized tomography (CT) images from thick-cut CT ones as inputs. First thick-cut CT images are obtained by maximizing the pixel-wise intensity of five or more than five continuous thin-cut ones after image registration. Second, the obtained thick-cut CT images are fed into a generator block which adopts an encoder-decoder architecture, where each thick-cut image is encoded into low-dimensional embedding space before decoding into multiple thin-cut ones. Third, a discriminator focuses on distinguishing original real thin-cut images from synthetic thin-cut images. An adversarial mechanism between the generator and discriminator causes the discriminator's output to provide an effective gradient update of the network parameters for the generator to increasingly improve the generator's ability to synthesize higher-quality thin-cut images and in turn promotes the discriminator's discriminating capability.

IPC Classes  ?

• G06T 3/00 - Geometric image transformation in the plane of the image

Abstract

Disclosed is a three dimensional classification system for recognizing cross-sectional images automatically containing a processor that executes: rescaling a plurality of cross-sectional images, and feeding the rescaled plurality of cross-sectional images into two branches; feeding the rescaled plurality of cross-sectional images into a first branch for performing a plurality of convolutions on the rescaled plurality of cross-sectional images directly to learn features for distinguishing phases; feeding the rescaled plurality of cross-sectional images into a second branch for reducing resolution, then performing a plurality of convolutions on the reduced resolution plurality of cross-sectional images to learn features for distinguishing phases; and concatenating convolutional output channels from the two branches to fuse global and local features, on which two fully-connected layers are stacked as a classifier to recognize cross-sectional volumetric images accurately and quickly.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

Disclosed is a system for stabilizing a power distribution network. The network is supplied at least partially by a renewable energy source. The system comprises a bidirectional AC-DC power conversion system between a supply 5 side distribution network and a load side grid, for converting a supply side AC voltage, at a supply side frequency, to a load side DC voltage; a voltage regulator for regulating the load side DC voltage; and a supply side control loop comprising at least one of a frequency control loop and a voltage control loop for making a measurement of a respective one of the supply side frequency and 10 supply side AC voltage, and controlling bidirectional power transmission between the bidirectional AC-DC power conversion system and one or more DC loads connected to the load side grid, based on the measurement from the respective frequency control loop and/or voltage control loop.

IPC Classes  ?

• H02J 3/18 - Arrangements for adjusting, eliminating or compensating reactive power in networks
• H02J 3/16 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by adjustment of reactive power
• B60L 53/50 - Charging stations characterised by energy-storage or power-generation means

Abstract

Described herein are dinuclear platinum (II) emitter complexes and their methods of making and using thereof. The design of the dinuclear platinum (II) emitters results in short radiative lifetimes and high quantum yields. The dinuclear platinum (II) emitter complexes can be used to fabricate blue emitting OLEDs.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 51/54 - Selection of materials

Abstract

Described herein are compounds containing palladium (II), as the central metal atom, and tetradentate [N^C^C^N] ligands. The compounds are charge neutral, and feature a donor-acceptor structure where a pendant substituted amino group (such as unsubstituted diphenylamine or substituted diphenylamine) and a heteroaryl group (such as pyridine group) serve as donor and acceptor, respectively. This donor-acceptor structure introduces a set of low-energy singlet and triplet charge-transfer excited states with small energy separation allowing for efficient thermally activated delayed fluorescence to take place.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Platinum (II) complexes ( "Pt (II) complexes" ) that can emit in the red and/or deep red regions and methods of making and using thereof are described. These Pt (II) complexes can have dinuclearity with close Pt-Pt contact and close interplanar distance, allowing for high emission quantum yield, such as > 50%, short emission lifetime, such as < 3 μs, and high radiative decay rate, such as in the order of 10 5s -1. The Pt (II) complexes disclosed herein can be included in organic light-emitting devices, such as organic light-emitting diodes ( "OLEDs" ), for use in commercial applications. OLEDs containing these red-emitting Pt (II) complexes can have current efficiency and/or external quantum efficiency that are comparable or higher than commercially available red emitters and prolonged operational lifetime, such as a LT95 at 1000 nits >9000 h for a red OLED.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)

Abstract

Devices and methods are provided that simplify and improve placement of stabilizing orthopedic pins, wires, and/or screws in the pelvis in minimally invasive surgery. Provided is a surgical instrument guide containing an adjustable friction clamp for positioning and securing a cannula, and a probe with a blunt, nonpenetrating tip. The probe and a surgical instrument held by the friction clamp are oriented at right angles to one another. In use, the blunt probe is introduced through a small incision and advanced by blunt dissection until the blunt tip is positioned at a desired anatomical landmark on the surface of the pelvis. A cannula inserted through the friction clamp is advanced until the tip of the cannula is within 2 cm of the blunt tip of the probe; an orthopedic pin, wire, and/or screw can then be inserted through the cannula to provide stabilization. The blunt probe may be cannulated.

IPC Classes  ?

• A61B 17/17 - Guides for drills
• A61B 17/90 - Guides therefor

Abstract

The present invention can inhibit dihydrofolate reductase in a microorganism. In some aspects, it may also suppress pigment formation in gram negative bacteria. The suppression of pigment formation can also mediate virulence suppression on other Gram negative bacteria. As such, the compounds may be used for microbial infections. The compounds can potentiate the effects of one or more antimicrobial agents when co-administered. Compositions including the compounds are provided. The composition can further include at least one antibiotic.

IPC Classes  ?

• A61K 31/426 - 1,3-Thiazoles
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/7008 - Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61P 31/04 - Antibacterial agents

Abstract

Described are fibula malleolus caps and surgery devices with fibula malleolus caps. The fibula malleolus caps may be patient-specific fibula malleolus caps. The devices with patient-specific fibula malleolus caps overcome the sliding and rotational errors during fibula flap harvesting. A comparative clinical study demonstrates that the fibula malleolus cap enhances the accuracy of fibula flap harvesting, leading to accurate location and angulation of simultaneous dental implants.

IPC Classes  ?

• A61F 2/46 - Special tools for implanting artificial joints
• A61F 2/28 - Bones

Abstract

An electromechanical sensor and a method of sensing an object or a tactile input using the sensor. The sensor includes: a base provided with a magnetic sensor arranged to detect a change in magnetic flux at the position of the magnetic sensor; a flexible film adjacent to the magnetic sensor; and a magnetic element provided on the flexible film; wherein the magnetic element is arranged to move relative to the magnetic sensor when the flexible film is reversibly deformed by an external force applied to the flexible film.

IPC Classes  ?

• G01R 33/06 - Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
• G01B 7/14 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring distance or clearance between spaced objects or spaced apertures
• G01B 7/24 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge using change in magnetic properties
• G01L 1/12 - Measuring force or stress, in general by measuring variations in the magnetic properties of materials resulting from the application of stress
• G01V 3/08 - Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination or deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices
• G01R 33/07 - Hall-effect devices
• G01D 5/14 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
• G01D 11/24 - Housings

Abstract

Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting in viral resistance. Preferably, the antiviral compositions contain P16 or a P16-like peptide which can both inhibit viral fusion and endosomal acidification to prevent viral entry through the endocytic pathway. The antiviral compositions can be used in methods of treating diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A (H1N1) pdm09 virus, avian influenza A (H7N9) virus, and the non-enveloped rhinovirus. The compositions are administered in a subject in need thereof in an effective amount to reduce or prevent viral replication in the subject, and thus reduce one or more symptoms of disease, disorder, or illness associated with virus.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 31/12 - Antivirals