A method of fabricating a nitrogen-vacancy (NV) center quantum sensing device based on electrohydrodynamic (EHD) printing. A nanopipette with an aperture at one end is filled with nanodiamond suspension ink so the ink is present in a meniscus at The aperture, the nanodiamond suspension ink comprises nanodiamonds and solvent. The nanopipette is supported above a substrate having a back electrode. A DC is applied pulse between the nanopipette and the back electrode so as to generate an electrostatic attractive force resulting in the ejection of nano-diamond-laden droplets with sub-attoliter volume. The droplet lands on the substrate and is allowed to dry due to solvent evaporation. Using the method, the control of the number of printed nano-diamonds is at will, attaining single-particle level precision. This printing approach, therefore, enables printing NV center arrays with a controlled number directly on the substrate without any lithographic process.
B41J 2/04 - Machines à écrire ou mécanismes d'impression sélective caractérisés par le procédé d'impression ou de marquage pour lequel ils sont conçus caractérisés par la mise en contact sélective d'un liquide ou de particules avec un matériau d'impression à jet d'encre caractérisés par le procédé de formation du jet en produisant à la demande des gouttelettes ou des particules séparées les unes des autres
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p.ex. nanocomposites
H10B 69/00 - Dispositifs de mémoire morte reprogrammable [EPROM] non couverts par les groupes , p.ex. dispositifs de mémoire morte reprogrammable aux ultraviolets [UVEPROM]
H10N 50/20 - Dispositifs à courant commandé à polarisation de spin
2.
FORMULATION OF AN ANTI-IL-4 RECEPTOR ALPHA MAB OR AN ANTIGEN-BINDING FRAGMENT THEREOF COMPRISING 2HPBETACD AND LEUCINE
A feed composition for spray drying comprises 2-hydroxypropyl-beta-cyclodextrin (2HPβCD), leucine, an anti-IL-4Rα antibody or an antigen binding fragment thereof, and a solvent. A method of preparing a pharmaceutical composition comprises a step of spray drying the feed composition by such as a spray dryer. A pharmaceutical composition comprises or consists of: 2HPβCD, leucine, an anti-IL-4Rα antibody or an antigen-binding fragment thereof. Use of the feed composition according to any of the pharmaceutical composition or according to any of the manufacture of a medicament for preventing or treating a disease, preferably, the disease is one that can be treated by the anti-IL-4R antibody or an antigen binding fragment thereof.
C07K 16/24 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
3.
COMPOSITIONS AND METHODS FOR ENHANCING EFFICACY AND REDUCING ADVERSE EFFECTS FROM COVID VACCINATION
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
Disclosed are methods for constructing disulfide mimetics for late-stage cyclization of peptides. The disclosed method provides late-stage cyclization via thioacetalization of peptides containing two cysteine residues to form thioacetal group. These bonds are stable under acidic, basic, and reduced conditions. The reaction can use a broad range of cyclic ketones even acetone as crosslinkers. Trifluoroacetic acid (TFA) alone can act as both the catalyst and the sole solvent, thus allowing most peptide sequences to be cyclized via the disclosed method. The disclosed method provides a number of benefits and advantages, such as the use of TFA as both a robust catalyst of the reaction and the sole solvent needed, the easy availability of acetone and of diverse cyclic ketones for use as the reactant, the good chemoselectivity and tolerance of native peptide to the reaction, and the fact that the resulting crosslinks are structural mimetics of disulfides.
232222-alkyl, SCHF-alkyl, S-alkyl, S-aryl, etc., onto tryptophan residue (s) of a peptide, in particular a native peptide. Generally, the late-stage peptide modification method includes: (i) maintaining a reaction mixture at a sufficient temperature for a sufficient period of time to form a product. The reaction mixture contains the peptide being modified, which contains one or more tryptophan residues; a sulfynyl reagent; and a solvent. The product formed in step (i) contains a sulfenylated peptide, where the sulfenylation is on at least one of the one or more tryptophan residues of the peptide.
C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C40B 50/08 - Synthèse en phase liquide, c. à d. dans laquelle tous les blocs servant à créer la bibliothèque sont en phase liquide ou en solution au cours de la création de la bibliothèque; Procédés particuliers de clivage à partir du support liquide
A fusion peptide comprising a coronavirus HR2-derived peptide fused to an ACE2-derived peptide or a lipopeptide comprising the fusion protein and cholesterol is a broad spectrum inhibitor of coronavirus.
A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is formed from the bone structure data set from step (i) and the implant data set from step (ii), and wherein the mesh-free model of trabecular bone is indicative of the trabecular bone structure of the bone structure at the anatomical site; and (iv) determining a biomechanical result based upon computer simulated loading of the bone-implant system based upon mesh-free analysis of the bone-implant model, wherein the biomechanical result includes data based on the displacement of the implant relative to the bone of bone-implant model.
G06F 30/20 - Optimisation, vérification ou simulation de l’objet conçu
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p.ex. pour des dossiers électroniques de patients
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p.ex. pour analyser les cas antérieurs d’autres patients
8.
GENERATIVE ADVERSARIAL NETWORK-BASED LOSSLESS IMAGE COMPRESSION MODEL FOR CROSS-SECTIONAL IMAGING
A novel medical image generation approach synthesizes thin-cut computerized tomography (CT) images from thick-cut CT ones as inputs. First thick-cut CT images are obtained by maximizing the pixel-wise intensity of five or more than five continuous thin-cut ones after image registration. Second, the obtained thick-cut CT images are fed into a generator block which adopts an encoder-decoder architecture, where each thick-cut image is encoded into low-dimensional embedding space before decoding into multiple thin-cut ones. Third, a discriminator focuses on distinguishing original real thin-cut images from synthetic thin-cut images. An adversarial mechanism between the generator and discriminator causes the discriminator's output to provide an effective gradient update of the network parameters for the generator to increasingly improve the generator's ability to synthesize higher-quality thin-cut images and in turn promotes the discriminator's discriminating capability.
Advanced Biomedical Instrumentation Centre Limited (Hong Kong)
Inventeur(s)
Xu, Lizhi
Zhu, Hengjia
Wang, Zuochen
Abrégé
The present invention provides a class of magnetic hydrogels with tissue-mimetic mechanical properties and photothermal welding/healing capability. In these hydrogels, a hybrid network involving aramid nanofibers, functionalized Fe3O4 nanoparticles, and polyvinyl alcohol (PVA) is accomplished by a stepwise assembly of the functional components. The engineered interactions between nanoscale constituents enable facile materials processing and confer a combination of excellent mechanical properties, magnetism, water content and porosity.
C08L 29/04 - Alcool polyvinylique; Homopolymères ou copolymères d'esters partiellement hydrolysés d'alcools non saturés avec des acides carboxyliques saturés
H01F 1/44 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriés; Emploi de matériaux spécifiés pour leurs propriétés magnétiques en liquides magnétiques, p.ex. ferrofluides
A61B 34/00 - Chirurgie assistée par ordinateur; Manipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
10.
DINUCLEAR PLATINUM (II) RED EMITTERS FOR OLED APPLICATIONS
Platinum (II) complexes (“Pt(II) complexes”) that can emit in the red and/or deep red regions and methods of making and using thereof are described. These Pt(II) complexes can have dinuclearity with close Pt—Pt contact and close interplanar distance, allowing for high emission quantum yield, such as >50%, short emission lifetime, such as <3 μs, and high radiative decay rate, such as in the order of 105 s−1. The Pt(II) complexes disclosed herein can be included in organic light-emitting devices, such as organic light-emitting diodes (“OLEDs”), for use in commercial applications. OLEDs containing these red-emitting Pt(II) complexes can have current efficiency and/or external quantum efficiency that are comparable or higher than commercially available red emitters and prolonged operational lifetime, such as a LT95 at 1000 nits>9000 h for a red OLED.
Advanced Biomedical Instrumentation Centre Limited (Hong Kong)
Inventeur(s)
Tian, Jingxuan
Shum, Ho Cheung
Dey Poonam, Aditi
Nan, Lang
Abrégé
A portable, miniaturized microfluidic droplet-based digital polymerase chain reaction (PCR) device is provided. The device includes a droplet generation layer with a flow-focusing channel and multiple capillary channels, in which the flow-focusing channel has a flow focusing structure to generate droplets from a provided aqueous sample and extract oil, and the multiple capillary channels is configured to perform an oil extraction. An incubation layer includes heating plates, a microfluidic channel, and a container for conducting a PCR thermal cycling program. Controlled by a controller and powered by a power supplier, the PCR thermal cycling program involves maintaining predefined temperatures on each heating plate sequentially. This process ensures the heating of droplets to different temperatures at distinct times, facilitating precise and efficient PCR amplification.
A three dimensional classification system for recognizing cross-sectional images automatically contains a processor that executes: (1) rescaling of a plurality of cross-sectional images; and feeding the rescaled plurality of cross-sectional images into two branches; (2) feeding the rescaled plurality of cross-sectional images into a first branch for performing a plurality of convolutions on the rescaled plurality of cross-sectional images directly to learn features for distinguishing phases; (3) feeding the rescaled plurality of cross-sectional images into a second branch for reducing resolution, and then performing a plurality of convolutions on the reduced resolution plurality of cross-sectional images to learn features for distinguishing phases; and (4) concatenating convolutional output channels from the two branches to fuse global and local features, on which two fully-connected layers are stacked as a classifier to recognize cross-sectional volumetric images accurately and quickly.
G06T 3/40 - Changement d'échelle d'une image entière ou d'une partie d'image
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p.ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersections; Analyse de connectivité, p.ex. de composantes connectées
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
G06V 10/80 - Fusion, c. à d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
13.
REMDESIVIR COCRYSTAL, COMPOSITIONS AND METHODS THEREOF
Advanced Biomedical Instrumentation Centre Limited (Chine)
Inventeur(s)
Chow, Shing Fung
Low, Kam Hung
Wong, Si Nga
Abrégé
Provided is a cocrystals of remdesivir (RDV) composed of a 1:1 molar ratio of RDV and benzoic acid derivative. The benzoic acid derivative can be salicylic acid (SA). The RDV-SA cocrystal are formed by either liquid-assisted grinding or spray-drying, followed by thermal annealing to facilitate cocrystal formation. The RDV-SA cocrystals can be formulated as inhalable dry powders and included in a medicament for use in treatments for influenza viral infections, such as COVID-19. The inhalable RDV-SA cocrystal dry powders is suitable for deep lung delivery, with good dissolution performance.
A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, DBA SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventeur(s)
Hui, Shu Yuen Ron
Tan, Siew Chong
Mi, Chunting Chris
Abrégé
Disclosed is a system for stabilizing a power distribution network. The network is supplied at least partially by a renewable energy source. The system comprises a bidirectional AC-DC power conversion system between a supply 5 side distribution network and a load side grid. for converting a supply side AC voltage, at a supply side frequency. to a load side DC voltage; a voltage regulator for regulating the load side DC voltage; and a supply side control loop comprising at least one of a frequency control loop and a voltage control loop for making a measurement of a respective one of the supply side frequency and 10 supply side AC voltage. and controlling bidirectional power transmission between the bidirectional AC-DC power conversion system and one or more DC loads connected to the load side grid. based on the measurement from the respective frequency control loop and/or voltage control loop.
H02J 3/32 - Dispositions pour l'équilibrage de charge dans un réseau par emmagasinage d'énergie utilisant des batteries avec moyens de conversion
H02J 3/16 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par réglage de puissance réactive
H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs
H02M 7/797 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant continu; Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif avec possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
15.
A MICROFLUIDIC PIPELINE FOR ISOLATION AND ANALYSIS OF SINGLE VIRUSES
Advanced Biomedical Instrumentation Centre Limited (Chine)
Centre for Immunology & Infection Limited (Chine)
Inventeur(s)
Shum, Ho Cheung
Poon, Lit Man
Nan, Lang
Lai, Man Yuk Alison
Abrégé
The subject invention pertains to a microfluidic pipeline which enables isolation and analysis of single viruses. Single viruses are encapsulated and manipulated within microfluidic droplets. The subject invention further pertains to the amplification of single viral genomes are amplified and confined within the droplets, followed by extraction and isolation of the single-droplet contents for sequencing analysis.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p.ex. séquençage par hybridation [SBH]
Disclosed are methods and compositions for use in preparing dynamic biological macromolecules for high-resolution cryo-electron microscopy or cryo-electron tomography imaging. The compositions contain a metallo-supramolecular branched polymer with a positive zeta potential, containing a hydrophilic polymer segment, a chelating chemical group, and a metal ion. The hydrophilic polymer segment is covalently bonded to the chelating chemical group that is in turn bonded to the metal ion via a dative bond. The methods and compositions can be used to improve particle distribution in vitreous ice and/or to change particle orientations in vitreous ice. Accordingly, the methods and compositions can be utilized to improve particle distribution for high resolution structure determination using single-particle cryo-EM.
G01N 1/42 - Traitement à basse température des échantillons, p.ex. cryofixation
G01N 23/225 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p.ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux en utilisant des microsondes électroniques ou ioniques
17.
METHODS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION SKELETAL SEQUELAE
Methods for treating or preventing a skeletal sequelae of a coronavirus infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae can include one or more of arthralgia, viral arthritis, osteopenia, osteochondral damage, and osteoporosis.
A method and systems for making predictions based on a classifierare provided. The method includes receiving a multivariate input having feature variables; making prediction based on a comonotone-independence Bayes classifier (CIBer) via performing conditional probability mass function on the feature variables; and outputting a predictive class. The making prediction based on the comonotone-independence Bayes classifier (CIBer) includes a joint encoding to artificially insert ordering in categorical features. The joint encoding is configured to preserve inherent dependence among the categorical features.
G06F 18/2415 - Techniques de classification relatives au modèle de classification, p.ex. approches paramétriques ou non paramétriques basées sur des modèles paramétriques ou probabilistes, p.ex. basées sur un rapport de vraisemblance ou un taux de faux positifs par rapport à un taux de faux négatifs
Southern University of Science and Technology (Chine)
Inventeur(s)
Chu, Zhiqin
Luo, Yumeng
Li, Kwai Hei
Abrégé
An opto chip for detecting a physical parameter of a liquid sample, comprising an optical structure monolithically integrated with a substrate layer and a functional layer, wherein the substrate layer is light-transmissive and configured to have an upper surface for receiving a droplet of the liquid sample and a lower surface bonded to the functional layer; and the functional layer comprises a light-emitting region and a light-detecting region with the light-emitting region being configured to emit measurement light. The light-detecting region is configured to receive reflected light derived from the measurement light and a signal reflecting the change in intensity thereof is converted into a photocurrent signal. A viscometer and detection method operated using the same opto chip technique. The need for complex external optical calibration is thus eliminated, making the viscometer easier to operate and reducing the overall size of the device.
G01N 11/10 - Recherche des propriétés d'écoulement des matériaux, p.ex. la viscosité, la plasticité; Analyse des matériaux en déterminant les propriétés d'écoulement en déplaçant un corps à l'intérieur du matériau
20.
BUILDING BLOCKS FOR DIFFICULT PEPTIDE SYNTHESIS AND METHOD OF MAKING THEREOF
Building block structures containing N, O/S-benzylidene acetal dipeptide (NBD) are described. The unique core structure of NBD can effectively convert those difficult peptide/proteins sequence into the easy ones, allowing smooth synthesis of those challenging targets. Further, the production of NBDs is highly robust, and it can be scale up facilely, which can facilitate the research and development of tailor-made peptides/proteins in the future.
A holographic near-eye display device capable of multi-angle simultaneous illumination, comprising a light source module, a spatial light modulator (130), a beam splitter (120), an eyepiece, and a master controller (150). The light source module is used for emitting parallel light of different angles to simultaneously illuminate and cover an effective working region of the spatial light modulator (130). The spatial light modulator (130) is loaded with a hologram and used for modulating incident parallel light of different angles to form diffracted parallel light of different angles, i.e., virtual images of different viewing angles. The parallel light of different angles illuminates the spatial light modulator (130) and is modulated and diffracted via a computer-generated hologram on the spatial light modulator (130), and diffracted image light is converged by a second lens (140) to form different viewpoints for viewing by human eyes. The multi-angle simultaneous illumination does not require additional time-sharing control of an illumination unit, and when the size and position of human eye pupils change, a clear virtual image can always be seen, thereby achieving the objective of expanding an eyebox.
Advanced Biomedical Instrumentation Centre Limited (Chine)
Inventeur(s)
Hassan, Sammer Ul
Shum, Ho Cheung
Lee, Pui Chung
Abrégé
A process and an apparatus conduct microfluidic loading and unloading of fluids into microchannels for performing assays, such as immunoassays. The apparatus includes a sequential loading and unloading unit having a movable member dipping a chip having a microchannel including a sample into a cartridge retaining a substance to guide the predetermined substance into the microchannel by capillary action to mix the predetermined substance with the sample. A signal detection unit performs an analysis of the mixed sample and generates an analysis message corresponding to the sample. An output device outputs the analysis message. The process implements operation of the apparatus.
G01N 33/543 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p.ex. verrerie de laboratoire; Compte-gouttes
23.
FABRICATION AND APPLICATION OF FIBER-BASED HYDROGEL USING ALL-AQUEOUS FORMULATIONS
Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work
Centre for Oncology and Immunology Limited (Chine)
Inventeur(s)
Wong, Siu Lun
Chu, Hoi Yee
Zhou, Peng
Fong, Hoi Chun
Abrégé
Engineered guide RNAs having enhanced stability of interaction with Cas enzymes are disclosed. The variant sgRNAs include engineered nucleic acids in or around the stem-loop 2 region which enhance interaction with the Cas9 enzyme and impart enhanced specificity and on-target editing activity. Compositions and methods of engineered guide RNAs are provided for enhanced genomic engineering with increased on-off target specificity and on-target editing efficacy.
Described herein are dinuclear platinum(II) emitter complexes and their methods of making and using thereof. The design of the dinuclear platinum(II) emitters results in short radiative lifetimes and high quantum yields. The dinuclear platinum(II) emitter complexes can be used to fabricate blue emitting OLEDs.
Advanced Biomedical Instrumentation Centre Limited (Chine)
Inventeur(s)
Xu, Lizhi
Li, Hegeng
Liu, Hongzhen
He, Huimin
Wang, Zuochen
Abrégé
A composite nanofiber aerogel (CNA) is formed from aramid nanofibers (ANFs) combined with polyvinyl alcohol (PVA). These nanoscale constituents of the aerogel form 3D networks with high nodal connectivity and strongly welded connectivity joints between fibrils so that the structure has high stiffness and strength compared to other polymeric aerogels and successive breakage of crosslinks at the connectivity nodes affords energy dissipation while maintaining the overall structural integrity. A specific class of CNA with a specific solid content may be used to form a thin firm with a composite nanofiber framework (CNFF) that is useful in the manufacture of kirigami wearable electronics.
C08J 9/00 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolaires; Leur post-traitement
C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolaires; Leur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p.ex. par séchage du coagulum
27.
PAIRED-CELL PROFILING SYSTEMS FOR HIGH-THROUGHPUT SCREENING SYNCYTIUM FORMATION
Centre for Oncology and Immunology Limited (Chine)
Advanced Biomedical Instrumentation Centre Limited (Chine)
Inventeur(s)
Wong, Siu Lun
Choi, Ching Gee
Shum, Ho Cheung
Chan, Wai Fong
Wang, Bei
Nan, Lang
Abrégé
Provided is a high throughput screening method for identifying cell fusion or syncytium formation potential. In particular, the cell fusion or syncytium formation potential of a viral spike protein. Also provided is a method for identifying a cellular factor that promotes spike protein-induced syncytium formation. Also provided is a method of inhibiting or suppressing syncytium formation induced by a viral spike protein.
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
Described herein are compounds containing palladium(II), as the central metal atom, and tetradentate [N{circumflex over ( )}C{circumflex over ( )}C{circumflex over ( )}N] ligands. The compounds are charge neutral, and feature a donor-acceptor structure where a pendant substituted amino group (such as unsubstituted diphenylamine or substituted diphenylamine) and a heteroaryl group (such as pyridine group) serve as donor and acceptor, respectively. This donor-acceptor structure introduces a set of low-energy singlet and triplet charge-transfer excited states with small energy separation allowing for efficient thermally activated delayed fluorescence to take place.
H10K 101/10 - Propriétés des matériaux organiques couverts par le groupe Émission de triplets
H10K 101/20 - Propriétés des matériaux organiques couverts par le groupe Émission de fluorescence retardée
H10K 102/00 - DISPOSITIFS ÉLECTRIQUES À L’ÉTAT SOLIDE ORGANIQUES - Détails de structure relatifs aux dispositifs organiques couverts par la présente sous-classe
29.
SCALABLE METHOD FOR ACHIEVING SHAPE CONTROL OF DIAMOND MICRO-NANOPARTICLES
Southern University of Science and Technology (Chine)
Dongguan Institute of Opto-electronics, Peking University (Chine)
Inventeur(s)
Chu, Zhiqin
Zhang, Tongtong
Wang, Qi
Wang, Zhongqiang
Li, Kwai Hei
Abrégé
The present invention provides a scalable method for achieving shape control of diamond micro-nanoparticles, comprising air oxidizing diamond micro-nanoparticles grown by chemical vapor deposition and/or diamond micro-nanoparticles grown by high pressure and high temperature. The present invention achieves the controllable morphology transformation of diamond micro-nanoparticles via air oxidation treatment. It has been demonstrated that a series of unique shapes, including “flower” shaped, “hollow” structured, “pyramid” patterned on the surface, and “boomerang” shaped, can be achieved by altering the air oxidation parameters, i.e., temperature and duration. The scalable production of these differently shaped diamond micro-nanoparticles represents a significant scientific breakthrough together with a high commercial value. The ability to produce diamond particles with desired shapes simply and cost-effectively will remove many obstacles to using diamonds for practical applications in nanophotonics, quantum computing, quantum optics, etc.
C23C 16/44 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement
C23C 16/511 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c. à d. procédés de dépôt chimique en phase vapeur (CVD) caractérisé par le procédé de revêtement au moyen de décharges électriques utilisant des décharges à micro-ondes
A method of treating a coronavirus infection in a subject in need thereof, the method including administering a therapeutically effective amount of an endothelin receptor antagonist to the subject, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 31/506 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/513 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p.ex. cytosine
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p.ex. cromakalim
A61K 31/422 - Oxazoles non condensés et contenant d'autres hétérocycles
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
ADVANCED BIOMEDICAL INSTRUMENTATION CENTRE LIMITED (Chine)
Inventeur(s)
Rafael, Remi
Chan, Kwok Leung
Abrégé
A method for printing electronic components is based on the hybridization of Fused Deposition Modeling (FDM) and laser sintering. The method involves printing a layer of composite copper-based thermoplastic filament on a base. Then the filament is subjected to a laser beam so as to selectively remove the polymer matrix in a restricted area after printing to leave only the conductive particles forming a highly conductive network and sintering the conductive particles with the laser energy to reveal the conductive copper. Then, alternately repeating the printing and sintering steps on the filaments one on top of the other until a complete component of arbitrary geometry, including both insulative and conductive structures, is formed layer-by-layer.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p.ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p.ex. modélisation par dépôt de fil en fusion [FDM]
B29C 64/194 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p.ex. lissage, meulage ou contrôle d’épaisseur pendant l’empilage des couches
B29C 64/371 - Conditionnement de l’environnement en utilisant un environnement autre que l’air, p.ex. un gaz inerte
A small volume optoelectronic chip contains an LED chip with a diamond having nitrogen-vacancy centers embedded therein. The LED chip generates light having a first wavelength, and the diamond with nitrogen-vacancy centers generates light having a second wavelength after excitement with light having the first wavelength. The diamond may also be on or adjacent the LED.
G01N 24/00 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin
G01N 24/10 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance paramagnétique électronique
H01L 33/02 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs
H01L 33/04 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs ayant une structure à effet quantique ou un superréseau, p.ex. jonction tunnel
33.
A-FABP NEUTRALIZING MONOCLONAL ANTIBODY AND PREPARATION METHOD AND USE THEREOF
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (Chine)
Inventeur(s)
Hoo, Lai Chong Ruby
Xu, Aimin
Liao, Boya
Chang, Junlei
Yang, Shilun
Li, Simeng
Abrégé
The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.
C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p.ex. composés antiphlogistiques et pour le cœur
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p.ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénal
34.
DEEP LEARNING MODEL FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA ON NON-CONTRAST COMPUTED TOMOGRAPHY
Disclosed is a computer-implemented three-dimensional image classification system (CIS) for processing and/or analyzing non-contrast computed tomography (CT) medical imaging data. The CIS is a deep neural network containing multiple Convolutional Block Attention Module (CBAM) blocks, which contain convolutional layers for feature extraction followed by CBAMs. The CBAM applies channel attention to highlight more relevant features and spatial attention to focus on more important regions. Max pooling layers operably link adjacent pairs of CBAM blocks. The output of the final CBAM block is passed to two terminal fully connected layers to generate a diagnosis. This classification system can be used to perform efficient diagnosis of hepatocellular carcinoma using solely non-contrast CT images, with diagnostic performance comparable to that of a radiologist using the current LIRADS system.
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p.ex. des objets vidéo
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p.ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicales; TIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p.ex. basé sur des systèmes experts médicaux
35.
METAL-ASSISTED MULTI-RESONANCE THERMALLY-ACTIVATED DELAYED-FLUORESCENCE EMITTERS FOR OLED APPLICATIONS
Described are multi-resonance-thermally-activated delay-fluorescence compounds containing (i) a polycyclic aromatic/heteroaromatic ligand in which a plurality aromatic/heteroaromatic rings are linked by boron and nitrogen atoms and (ii) an N-heterocyclic carbene ligand, with both ligands coordinated to a metal atom/ion that has a high spin-orbit coupling. The use of the high spin-orbit coupling of metals and/or metal ions facilitates the intersystem crossing and/or reversed intersystem crossing processes of MR-TADF emitters, thereby largely accelerating the rate of TADF and substantially shortening the lifetime of deleterious triplet excitons. The MR-TADF emitters can be used to fabricate blue to green emitting OLEDs.
Centre for Virology, Vaccinology and Therapeutics Limited (Chine)
THE HOSPITAL AUTHORITY (Chine)
Inventeur(s)
To, Kelvin Kai-Wang
Sridhar, Siddharth
Yuen, Kwok-Yung
Yip, Chik Yan
Abrégé
Sequences for detection of SARS-CoV-2 are provided and include example, SEQ ID NOs:4-8. The sequences are useful for amplifying the SARS-CoV-2 nsp8 gene in a sample, using Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) and it is preferably used in combination with a Cas enzyme/sgRNA pair and a reporter nucleic acid.
Sequences for detection of SARS-CoV-2 are provided and include example, SEQ ID NOs:4-8. The sequences are useful for amplifying the SARS-CoV-2 nsp8 gene in a sample, using Reverse Transcriptional Loop-Mediated Isothermal Amplification (RT-LAMP) and it is preferably used in combination with a Cas enzyme/sgRNA pair and a reporter nucleic acid.
The disclosed sequences can be use in methods of detecting SARS-CoV-2 nucleic acids in a sample. Generally, the specific gene sequence of SARS-CoV-2 RNA, herein nsp8, is amplified using RT-LAMP. The RT-LAMP products are scanned by the Cas12a-gRNA ribonucleoprotein (RNP) complex. The RNP binds to the specific complementary to gRNA, activating the transcleavage activity of Cas12a. The active Cas12a system cleaves a short ssDNA reporter that is labeled preferably, with a fluorophore and a quencher on either end. Cleavage of the reporter separates the quencher from the fluorophore, and fluorescence that is detectable with the naked eye is generated.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
37.
A STEERABLE ARM FOR USE IN ENDOSCOPIC SURGICAL PROCEDURES
A steerable arm for use in endoscopic surgical procedures. The steerable arm cut from a tube of nitinol to provide flexibility and resilience by the structure into which the tube is cut. Typically, the cut tube comprises a spiralling coil, the loops of which are in contact on one lateral side of the tube and the tube is bent to open apart the loops on the other lateral side. The material which the tube is made of is capable of retaining memory of the bend. This provides a bias for restoring the tube to the bend whenever a force causing the tube to flex is removed.
A61B 1/018 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments caractérisés par les conduits internes ou par leurs accessoires destinés à recevoir des instruments
A61B 34/00 - Chirurgie assistée par ordinateur; Manipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
38.
COMPOSITIONS IMMUNOGENIC AGAINST INFLUENZA AND SARS CORONAVIRUS 2, METHODS OF MAKING AND USING THEREOF
Live attenuated viruses for protection against the novel coronavirus Sars-CoV-2 are provided. The live attenuated chimeric virus strains are based on a live attenuated influenza A or B virus (LAIVA/B), used a master backbone, which includes deletion of the viral virulence element, the NS1 (non-structural protein 1) (DeLNS1), engineered to express one or more antigens of the Sars-CoV-2 (herein, CoV2Ag). The chimeric virus strain is referred to generally herein, as DelNS1-A/B-Sars-CoV-2-CoV2Ag. The DelNS1-A/B-Sars-CoV-2-CoV2Ag strain preferably shows spontaneous cold adaption with preference to grow at 30-33° C. Compositions including the chimeric virus also provided as a co-composition with a LAIVA/B. The DelNS1-A/B-Sars-CoV-2-CoV2Ag strain can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2. The co-compositions can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2 and influenza A and/or B.
DONGGUAN INSTITUTE OF OPTO-ELECTRONICS, PEKING UNIVERSITY (Chine)
Inventeur(s)
Chu, Zhiqin
Zhang, Tongtong
Wang, Qi
Wang, Zhongqiang
Abrégé
The present invention provides a diamond particle-based physical unclonable function material, and a preparation method therefor and a use thereof. The material comprises a monocrystalline silicon substrate, and diamond particles having silicon vacancy color centers and grown in situ on the monocrystalline silicon substrate. Preparation of the diamond particles on the silicon substrate relates to a random process, which is a key requirement for manufacturing a physical unclonable function label. According to the present invention, the scattering spectra, morphology features and spatial position relationship of the diamond particles are used as fingerprint information of the diamond physical unclonable function material. Due to extreme heat resistance, mechanical, chemical and light stabilities of a diamond material, the high-robustness label in the present invention can meet the requirements of many practical uses in various environments, and has practical commercial value in huge anti-counterfeit markets such as electronic components, medical packages, vehicles, and luxury goods.
CENTRE FOR VIROLOGY , VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Zhou, Jie
Chiu, Man Chun
Li, Cun
Yuen, Kwok Yung
Abrégé
Provided is a robust nasal organoid culture system and fully characterized 2D and 3D in-vitro generated organoids, and methods of using the organoids. The nasal organoids contain a population of differentiated nasal epithelial cells having cellular heterogeneity and molecular markers similar to mature nasal epithelial tissue. Improved methods for generating two-dimensional and three-dimensional nasal organoids are also provided. The methods generally require a two-phase culture system, i.e., expansion and differentiation culture. The provided nasal organoids are suitable for recapitulating nasal tissue complexity for modeling respiratory diseases, studying barrier function and drug delivery, high-throughput drug screening, and assessing the effects of pathogens and environmental toxins on the nasal respiratory epithelium.
C12N 5/071 - Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
A61K 35/36 - Substances provenant de mammifères; Compositions comprenant des tissus ou des cellules non spécifiés; Compositions comprenant des cellules souches non embryonnaires; Cellules génétiquement modifiées Épiderme; Cellules épithéliales; Kératinocytes; Cellules de Langerhans; Cellules ectodermiques
41.
Rechargeable Aqueous Mg Battery with a Solid-State Polymer Electrolyte
A rechargeable aqueous Mg battery is composed of a Mg metal anode, a solid-state aqueous polymer-based electrolyte, and an intercalation-type Prussian blue analogue cathode for ion storage. During battery operation, the Mg anode undergoes dissolution and deposition, while Mg ions in the electrolyte inserts and extracts from the cathode lattice, thereby releasing energy during discharge and storing energy during charge.
The subject invention pertains to a new method for measuring the elastic properties of microfibers by rope-coiling. Rope-coiling refers to the buckling of a slender elastic fiber caused by axial compression. A continuous flow microfluidic method enables the high-throughput measurement of the elasticity of microfibers by rope-coiling, where sample loading and unloading are not needed between consecutive measurements. In certain embodiments the coiling radius can be directly proportional to the elastic modulus of the fiber, facilitating calibration to measure fiber elasticity for high-throughput applications. Throughput can be thousands of times higher than that of a tensile tester, making possible an in situ, on-line measurement in a microfluidic production line, which couples the making of microfibers and the measurement of elasticity on the same line. The new method can also measure certain fibers with local variations in elasticity.
G01N 3/06 - Adaptations particulières des moyens d'indication ou d'enregistrement
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
43.
ZEBRAFISH MODEL OF HUMAN ACUTE MYELOID LEUKEMIA AND METHOD OF USE THEREOF
Genetically modified zebrafish, in which mutation combinations frequently identified in human AML are stably expressed in the stem cell population of the fish, are provided. The combination of mutations result in morphologic, cytochemical and molecular changes of its blood cells that are remarkably similar to those in human AML. The zebrafish model provides a foundation for the study of AML initiation and progression and a high throughput in vivo drug screening platform to identify personalized therapies for AML based on specific mutation combinations. The method of drug screening includes contacting embryos or adult fish containing mutations as disclosed herein, with a test agent, at test concentrations and test intervals to determine the therapeutic effect if any, of the test agent.
The invention relates to the field of biomedicine. In particular, the invention relates to a live strain of Staphylococcus aureus and uses thereof. More particularly, the invention relates to a live strain of Staphylococcus aureus which lacks adenosine synthase A (AdsA) activity, to a vaccine against Staphylococcus aureus infection comprising said live strain, and a method for preventing and/or treating Staphylococcus aureus infection in a subject by administering said live strain.
The subject invention pertains to a system for the electrochemical conversion of nitrate to ammonia. The electrolysis is carried out using a cell with a working electrode having a CuDATA molecular catalyst absorbed on carbon black. The system is effective for the conversion of waste nitrate solutions to ammonia. The conversion occurs with a high faraday efficiency of about 98%.
C25B 11/091 - PROCÉDÉS ÉLECTROLYTIQUES OU ÉLECTROPHORÉTIQUES POUR LA PRODUCTION DE COMPOSÉS ORGANIQUES OU MINÉRAUX, OU DE NON-MÉTAUX; APPAREILLAGES À CET EFFET Électrodes; Leur fabrication non prévue ailleurs caractérisées par le matériau Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
Disclosed are methods of purifying nanodiamonds and a method of making essentially pure nanodiamonds each involving mixing nanodiamonds with at least one salt to form a mixture; heating the mixture at a temperature from 200° C. to 1,000° C. for a time from 10 minutes to 10 hours; and combining a liquid with the heated mixture and centrifuging at a speed of 30 rcf to 25,000 rcf for a time from 10 seconds to 60 minutes to provide purified nanodiamonds. With the methods of the invention, pure NDs can be produced by one-step processing after air oxidation, without the need for any further centrifugation acts. Furthermore, the developed salt-assisted air oxidation method enables facile scale-up manufacturing of clean NDs, with a rounded shape transformed from original shard-like shape, which is impossible to achieve using any existing purification method.
Advanced Biomedical Instrumentation Centre Limited (Chine)
Inventeur(s)
Chow, Shing Fung
Low, Kam Hung
Wong, Si Nga
Abrégé
The subject invention pertains to cocrystals of dexamethasone (DEX) and a benzenediol cocrystal composed of a 1:1 molar ratio of DEX and the benzenediol. The benzenediol can be catechol (CAT) or resorcinol (RES). The DEX and benzenediol cocrystal are formed by grinding crystalline DEX where the crystalline benzenediol are combined in the 1:1 molar ratio. Grinding can be performed at room temperature. Cocrystals can be thermally annealed or exposed to humidity to enhance cocrystal formation. The DEX−CAT or DEX-RES cocrystals can be included in a medicament for use in treatments for allergies, asthma, rhinitis, cancer, diabetes, anemia, ulcers, and viral infections. The DEX−benzenediol cocrystal can be sieved to provide particles that are in the range of 10 to 45 μm that can be used for intranasal administration with improved dissolution performance.
C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p.ex. cholane, cholestane, coprostane
C07C 37/84 - Séparation; Purification; Stabilisation; Emploi d'additifs par traitement physique par cristallisation
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
48.
Nano robotic system for high throughput single cell DNA sequencing
A nano scale robotic system for single cell DNA sequencing of a strand of DNA positioned on a slide utilizes an atomic force microscope (AFM) having an end effector in the form of a cantilever with a tip. The AFM causes its cantilever tip to scan over the base pairs of the DNA strand. A pair of spaced-apart electrodes at the tip makes contact with opposite sides of the DNA strand and the current between bases of the DNA strand is measured by a current measurement system connected to the electrodes. An artificial intelligence-based data analytic system determines the DNA sequence based on the current from the current measuring system. The AFM tip is guided over the DNA strand by comparing compressed desired intensity local scan images and compressed actual intensity local scan images and using the difference to control the location of the tip.
G01Q 30/02 - Dispositifs d'analyse d’un type autre que la microscopie à sonde à balayage SPM, p.ex. microscope électronique à balayage SEM [Scanning Electron Microscope], spectromètre ou microscope optique
G03F 7/00 - Production par voie photomécanique, p.ex. photolithographique, de surfaces texturées, p.ex. surfaces imprimées; Matériaux à cet effet, p.ex. comportant des photoréserves; Appareillages spécialement adaptés à cet effet
The subject invention pertains to a Cas9 protein with an amino acid mutation at residues 888, 889, or a combination thereof of a WED domain and/or residues 988, 989, or a combination thereof of a PI domain. The subject invention can further pertain to a Cas9 protein with mutations at amino acid positions N986, D987, L988, L989, or any combination thereof. The subject invention also pertains to a method of enhancing the activity of KKH-SaCas9. In addition, a method of machine learning-based in silico screens for genome editing protein engineering is provided, including steps of populating a predictive machine learning model with an input dataset comprising empirical measurements of on-target activities of sgRNAs paired with a screening library of genome editing enzyme variants; running the predictive machine learning model with predefined parameters; and evaluating performance of the predictive machine learning model.
Disclosed is a method of obtaining preparing an extract of Spatholobus suberectus Dunn, which contains total flavonoid and proanthocyanidins. The disclosure relates to a method for extracting an active fraction from Spatholobus suberectus. Also provided is the SSP, the active fraction, and a composition thereof. Further provided is a method of treating viral diseases such as COVID-19 disease caused by SARS-CoV-2, and use of the SSP and the active fraction in the manufacture of preparations for prevention and/or treatment of a viral disease.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p.ex. cannabinols, méthanthéline
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):
The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.
C07D 295/08 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de car avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons simples
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
C07D 215/58 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée avec des hétéro-atomes liés directement à l'atome d'azote du cycle
C07D 217/06 - Composés hétérocycliques contenant les systèmes cycliques de l'isoquinoléine ou de l'isoquinoléine hydrogénée avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux atomes de carbone du cycle contenant l'azote; Alkylène-bis-isoquinoléines avec l'atome d'azote du cycle acylé par des acides carboxyliques, par l'acide carbonique ou par leurs analogues du soufre ou de l'azote, p.ex. des carbamates
Disclosed is a flexible battery made of a cathode comprising printable graphite, the cathode positioned on a first side of a paper; an anode comprising aluminum on a second side of the paper; an aqueous electrolyte comprising water and an aluminum halide, the aqueous electrolyte saturated within the paper; and an encapsulating film surrounding the anode and cathode.
LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LIMITED (Chine)
Inventeur(s)
Che, Chi Ming
Fu, Zhiwen
Leung, Yiu Chung Gulice
Abrégé
Synthetic agrimol B and derivatives thereof ( "compounds" ) that have anticancer properties are disclosed. Methods for synthesizing the compounds with an overall yield ≥ 7% are disclosed. Pharmaceutical formulations in forms suitable for the delivery of the compounds to a subject in need thereof are disclosed. Methods of using the compounds for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer, such as non-small-cell lung cancer, in a subject are also disclosed. The methods include (i) administering to the subject the pharmaceutical formulation containing one or more compounds, for one or more times. The compounds can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by inducing mitochondria dysfunction and/or inhibiting ER to Golgi trafficking in the cancer cells and/or cancer stem cells.
C07C 49/84 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
C07C 49/83 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes hydroxyle polycycliques
C07C 45/45 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogène; Préparation des chélates de ces composés par condensation
C07C 45/61 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogène; Préparation des chélates de ces composés par des réactions ne créant pas de groupe C=O
Disclosed in the present invention are benzothiazole compounds as well as a preparation method therefor and the use thereof. The compounds have a great inhibition effect on SARS-CoV-2 and can be used for resisting the novel coronavirus. (I)
C07D 277/66 - Benzothiazoles avec uniquement des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués liés en position 2 avec des cycles ou des systèmes cycliques aromatiques liés directement en position 2
C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61K 31/428 - Thiazoles condensés avec des carbocycles
A61P 31/14 - Antiviraux pour le traitement des virus ARN
55.
Targeting papain-like protease for broad-spectrum coronaviruses inhibition
Centre for Virology, Vaccinology and Therapeutics Limited (Chine)
Inventeur(s)
Yuan, Shuofeng
Chan, Fuk Woo Jasper
Yuen, Kwok Yung
Abrégé
The subject invention pertains to compounds and methods of using said compounds to target the multi-functional papain-like protease (PLpro) domain of the viral Nsp3, specifically F0213, F0326, and F0393 that can have broad anti-coronavirus activity, including SARS-CoV-2, MERS-CoV, and coronaviruses hCoV-229E and hCoV-OC43. F0213, F0326, and F0393 can possess a dual therapeutic functionality that suppress CoV replication via blocking viral polyprotein cleavage, as well as promote antiviral immunity by antagonizing the PLpro deubiquitinase activity.
A61K 31/519 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p.ex. amorces ou sondes pour la détection ou l’identification d’organismes
56.
RATIONALLY DESIGNED SINGLE-ROUND INFECTIOUS VIRUS AND METHODS OF USE THEREOF
CENTRE FOR VIROLOGY , VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Kok, Kin Hang
Yuen, Chun Kit
Yuen, Kwok Yung
Wong, Wan Man
Abrégé
Provided are engineered, replication-deficient influenza viruses that are infectious and stimulate broadly-cross protective immunity against multiple different influenza strains. Also provided are compositions and methods for providing protective immune responses against influenza. The methods deliver compositions of intact, replication-deficient influenza viruses by intradermal administration in an amount effective to elicit or stimulate a cross-protective immune response to influenza viruses in the recipient following a single administration. Because the engineered influenza viruses are non-replicating, they are safe and effective in immunocompromised subjects. Also provided are methods for delivering co-stimulatory molecules, growth factors, adjuvants and/ or cytokines together with the non-replicating influenza viruses.
Laboratory for Synthetic Chemistry and Chemical Biology Limited (Chine)
Inventeur(s)
Che, Chi Ming
Wang, Tingting
Wang, Haixu
Abrégé
Methods for asymmetric cis-dihydroxylation (“AD”) of quinones to produce cis-diols of quinones with high yield (i.e. a yield ≥30%) and high enantioselectivity (i.e. an enantiometric excess ≥30%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst, and can be performed under mild reaction conditions (e.g. a temperature ≤50° C. at 1 atom in open air). The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a quinone, one or more iron-based catalyst(s), and a solvent, and where the product contains a chiral cis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.
C07C 50/30 - Quinones contenant des groupes dont les atomes d'oxygène sont liés par liaison simple à des atomes de carbone à structure quinoïde polycyclique non condensée
C07C 50/36 - Quinones contenant des groupes dont les atomes d'oxygène sont liés par liaison simple à des atomes de carbone la structure quinoïde faisant partie d'un système cyclique condensé d'au moins quatre cycles
C07C 50/34 - Quinones contenant des groupes dont les atomes d'oxygène sont liés par liaison simple à des atomes de carbone la structure quinoïde faisant partie d'un système cyclique condensé à trois cycles
LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LIMITED (Chine)
Inventeur(s)
Che, Chi Ming
Wang, Tianting
Wang, Haixu
Abrégé
ciscisciscis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.
C07C 29/48 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par des réactions d'oxydation avec formation de groupes hydroxyle
C07C 35/14 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons monocycliques contenant des cycles à six chaînons avec plusieurs groupes hydroxyle liés au cycle
B01J 31/28 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant en outre des composés métalliques inorganiques non prévus dans les groupes du groupe du platine, du cuivre ou du groupe du fer
59.
COMPOSITIONS AND METHODS FOR IMPROVED MESENCHYMAL STEM CELL THERAPY
It has been established that CD55 expression on human mesenchymal stem cells (hMSCs) is positively correlated with successful allogenic transplantation procedures. Compositions and methods for improved hMSCs, having increased expression of CD55 mRNA and/or increased expression of CD55 on the surface of the cell as compared to a control cell, are provided. Methods include isolating hMSCs from a tissue that naturally has increased CD55 expression, such as adipose tissue derived hMSC (AT-hMSC); and/or in vitro culturing hMSCs in the presence of one or more active agents that stimulates or enhances the expression of CD55 mRNA, and/or increases the surface expression of CD55 in the hMSC to provide improved hMSCs. Preferred active agents include HMG-CoA reductase inhibitors such as atorvastatin and EGFR inhibitors such as erlotinib. Compositions and methods for administering the improved hMSCs to a subject in need thereof are also provided.
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/517 - Pyrimidines; Pyrimidines hydrogénées, p.ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p.ex. quinazoline, périmidine
A61P 37/06 - Immunosuppresseurs, p.ex. médicaments pour le traitement du rejet de greffe
CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Zhao, Hanjun
Yuen, Kwok-Yung
Abrégé
Antiviral peptides and formulations thereof are described for use in treating or preventing one or more symptoms of coronavirus infections. Peptides derived from human beta defensin 2 have been shown to have antiviral properties against different variants of coronavirus including cross-linking viral particles, blocking cell-to-cell fusion, and/or inhibiting viral release. Pharmaceutical compositions and methods of using one or more antiviral peptides are also provided. Preferably, the antiviral peptides are administered via intranasal route to prevent or alleviate one or more symptoms of coronavirus infections such as reducing the syncytial formation and lung damage.
C07K 14/47 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Chen, Zhiwei
Zhou, Runhong
Zhou, Biao
Luo, Mengxiao
Chen, Bohao
Abrégé
Disclosed are compositions and methods using antibodies and antibody fragments that bind SARS-CoV-2 spike protein or receptor binding domain (RBD). Generally, the CDRs of the antibodies and antigen binding fragments comprise: (a) the three light chain CDRs selected from the group consisting of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, and 64; and (b) the three light chain CDRs selected from the group consisting of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, and 63.In some forms, the antibody is a bispecific antibody.
Provided are a composition comprising a peptide conjugated to a TLR agonist, including TLR7 agonist 1v209, and methods of using the composition. The methods comprise administering the peptide-based vaccine conjugate to a subject. The peptide-based vaccine conjugate inhibits tumor growth and induces antigen-specific B and T cell responses in a subject.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p.ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 31/4745 - Quinoléines; Isoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. phénanthrolines
ADVANCED BIOMEDICAL INSTRUMENTATION CENTRE LIMITED (Chine)
Inventeur(s)
Wong, Kenneth Kin Yip
Shi, Jiawei
Li, Mingsheng
Kang, Jiqiang
Abrégé
An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950/1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50/50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p.ex. commutation, ouverture de porte, modulation ou démodulation
H01S 3/094 - Procédés ou appareils pour l'excitation, p.ex. pompage utilisant le pompage optique par de la lumière cohérente
H01S 3/00 - Lasers, c. à d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
H01S 3/108 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p.ex. commutation, ouverture de porte, modulation ou démodulation par commande de dispositifs placés dans la cavité utilisant des dispositifs optiques non linéaires, p.ex. produisant une diffusion par effet Brillouin ou Raman
G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets
H01S 3/23 - Agencement de plusieurs lasers non prévu dans les groupes , p.ex. agencement en série de deux milieux actifs séparés
H03F 3/19 - Amplificateurs à haute fréquence, p.ex. amplificateurs radiofréquence comportant uniquement des dispositifs à semi-conducteurs
G01N 33/483 - Analyse physique de matériau biologique
Compositions and immunoassays for detecting SARS-CoV-2 antigen-specific antibodies in a biological sample are provided. The compositions are antigens from SARS-CoV-2 such as the proteins N, M, S, S1, S2′, NSP1, ORF3a, ORF3b, ORF7a, ORF7b and ORF8, fused to a light emitting protein. The compositions are useful in immunoassays for detecting antibodies to the SARS-CoV-2 antigens. A preferred immunoassay is the luciferase immunoprecipitation systems (LIPS) to detect SARS-CoV-2 antigen-specific antibodies with high sensitivity and specificity. The current or present exposure or infection with SARS-CoV-2 can be detected and/or diagnosed using the disclosed compositions and methods. Typically, the presence and/or elevated amount of SARS-CoV-2 antibodies in the individual’s biological sample compared to a control is indicative of current or past exposure or infection with SARS-CoV-2 as discussed herein.
C07K 14/005 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de virus
G01N 33/569 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour micro-organismes, p.ex. protozoaires, bactéries, virus
65.
COMPACT, LIGHTWEIGHT HYDRAULIC MANIPULATION SYSTEM FOR UNDERWATER APPLICATIONS
Disclosed is a compact, lightweight hydraulic manipulation system used for underwater applications consisting of two parts: a modulus hybrid underwater manipulator and a compact lightweight hydraulic control framework. The system is used for general underwater work such as underwater sampling, hyperbaric welding, and marine aquaculture.
A method and system for encrypting and decrypting authentication information about a synthetic Raman diamond tag formed with predetermined defects, impurities and/or strains in its crystal structure. A sender uses an optical spectrometer to establishing authentication identities of the synthetic diamond Raman tag and the sender's nature by means of Raman scanning. The sender then encrypts information about the synthetic Raman diamond tag and the sender, and transfers the Raman tag physically to a receiver and the encrypted information electronically to the receiver. The receiver first authenticates the diamond Raman tag and second authenticates the sender's nature. The receiver decrypts the encrypted information by reverse Raman scanning only if the first and second authenticating steps are successful.
Described herein are two-coordinated d10 metal carbene complexes containing (i) Cu (I), Ag (I), or Au (I), (ii) a pyrazine-fused NHC ligand or a pyridine-fused NHC ligand, and (iii) a carbazole ligand, a pyrido [2, 3-b] indole ligand, or a pyrido [3, 4-b] indole ligand. The radiative properties of the compounds can be controlled by thermally activated delayed fluorescence. The emission colors of the complexes can be tuned by using carbazoles with varying donor strength. Also described are methods of using the complexes.
Described herein are two-coordinated d10 metal carbene complexes containing (i) Cu(I), Ag(I), or Au(I), (ii) a pyrazine-fused NHC ligand or a pyridine-fused NHC ligand, and (iii) a carbazole ligand, a pyrido[2,3-b]indole ligand, or a pyrido[3,4-b]indole ligand. The radiative properties of the compounds can be controlled by thermally activated delayed fluorescence. The emission colors of the complexes can be tuned by using carbazoles with varying donor strength. Also described are methods of using the complexes.
Centre for Virology, Vaccinology and Therapeutics Limited (Chine)
Inventeur(s)
Zhao, Hanjun
Yuen, Kwok-Yung
Abrégé
The disclosure relates to defective interfering genes and viruses thereof. It has been discovered that defective interfering genes designed from influenza and coronavirus species can inhibit infection or replication of the parent virus. In vivo, DIGs induce rapid-onset prophylactic protection of infected animals against lethal viral doses. Thus, disclosed herein are nucleic acids containing DIGs, pharmaceutical compositions thereof and associated methods of use. For example, described herein is an isolated polynucleotide containing one or more defective interfering genes, wherein each of the one or more defective interfering genes contains a nucleotide sequence corresponding to one or more portions of an influenza or coronavirus gene or genome, wherein the nucleotide sequence includes a deletion in the gene. The DIGs can be in the form of a plasmid. Pharmaceutical compositions of the plasmid can be used to limit viral replication and prevent or treat influenza or coronavirus associated diseases.
The present invention provides an antibacterial and antiviral copper-containing stainless steel, and a preparation method for and the use of a stainless steel conforming to the composition thereof. The copper-containing stainless steel comprises a stainless steel matrix and a copper-rich phase evenly distributed in the stainless steel matrix, wherein the copper content of the copper-containing stainless steel is 6-30 wt%. The preparation method therefor comprises the manufacturing of a small stainless steel product mainly using powder metallurgy technology, and the manufacturing of a large stainless steel sheet, bar or pipe mainly using a composite process without significant thermal deformation. Compared with a traditional antibacterial stainless steel, the composition design of the present invention contains sufficient copper-rich precipitated phases, such that the antibacterial and antiviral copper-containing stainless steel of the present invention can achieve both a good killing effect on bacteria and a virus killing capacity comparable with that of pure copper, can be used for preparing the integral body or the whole of parts such as cutters, elevator buttons, railings, handrails, door handles and cups, and can effectively kill bacteria and viruses existing on the surfaces thereof.
Provided are two fully humanized Δ42PD1-specific mAbs, specifically huCH101 and huCH34 at 97.0% humanness by CDR grafting. Provided is a method of using huCH101 and/or huCH34 to treat subjects in need of Δ42PD1-specific mAb, including subjects with cancer and/or infection.
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A UV based surface disinfection system that consists of the UV light source, a robot arm, and an omni directional mobile base. The mobile robot can be programmed autonomously and be able to bring the UV light source to the centimeters away from surfaces to achieve effective and efficient surface disinfection. The mobile robot can navigate autonomously in a complicated environment to perform disinfection operation in a large area.
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contact; Accessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
The present invention relates to a compound for treating fungal disease, wherein said compound provide target-specific inhibition of fungal adhesion, biofilm formation, and filamentation without affecting their growth, at very low concentration. The compound of the present invention is selected from FDA approved drugs Cangrelor. Further, the present invention provides a composition comprising compound of the present invention and a pharmaceutically acceptable carrier. Further, the present invention provides a method of treating fungal infections using the compound and/or composition of the present invention. Furthermore, uses of the compound and/or composition is also being provided in the present disclosure.
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p.ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p.ex. adénosine, acide adénylique
A61P 31/00 - Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LIMITED (Chine)
Inventeur(s)
Che, Chi-Ming
You, Tingjie
Abrégé
Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.
C07D 207/06 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 403/10 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
77.
AEROSOLIZED VITAMIN A FOR MANAGEMENT OF COVID–19-RELATED OLFACTORY DYSFUNCTION
CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
HALCYON LIFE SCIENCES TECHNOLOGY LIMITED (Chine)
Inventeur(s)
Chung, Wai Hin
Hung, Ivan Fan Ngai
Sze, Kong Hung
Sridhar, Siddharth
Yan, Bingpeng
Yuen, Kwok Yung
Abrégé
Disclosed are compositions and methods useful for management of rhinological, neurological, or psychiatric complaints and disorders. The rhinological, neurological, or psychiatric complaint and disorder can be one that affects the normal human neurosensory, neurocognitive, or neuropsychiatric functions, including but not limited to olfactory dysfunction. The complaint or disorder can be one that is related to coronavirus disease 2019 (COVID-19), including but not limited to olfactory dysfunction. Disclosed are compositions including a vitamin A solution and an essential oil mixture. The vitamin A solution can be a vitamin A compound and a nontoxic solvent, such as a pharmaceutically acceptable solvent. The vitamin A compound can be at a concentration of from 10,000 to 120,000 international units (IU). The vitamin A solution and the essential oil mixture can be in a ratio of from 4: 1 to 1: 4 in the composition. The composition of vitamin A solution and essential oil mixture can be aerosolized and administered via the subject's nose.
Provided herein is DNA vaccine and composition comprising PD1-based TWIST1. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine and an immune checkpoint inhibitor.
The subject invention pertains to methods and compositions for treating hypertension. In specific embodiments, the methods comprise administering KSD179019 to a subject in need of hypertension treatment. In further embodiments, the methods comprise administering a KSD179019 analog or derivative to a subject in need of hypertension treatment. Also provided are methods to design and manufacture KSD179019 analogs and derivatives with enhanced and prolonged anti-hypertensive therapeutic efficacy.
Live attenuated viruses for protection against the novel coronavirus, designated as Sars-CoV-2 by the World Health Organization (WHO) are provided. The live attenuated chimeric virus strains are based on a live attenuated influenza B virus (LAIVB), used a master backbone, which includes deletion of the viral virulence element, the NS1 (non-structural protein 1) (DeLNS1-B), engineered to express one or more antigens of the Sars-CoV-2 (herein, CoV2Ag). The chimeric virus strain is referred to generally herein, as DelNS1-B-Sars-CoV-2-CoV2Ag. The DelNS1-B-Sars-CoV-2-CoV2Ag strain preferably shows spontaneous cold adaption with preference to grow at 30-33° C. The DelNS1-B-Sars-CoV-2-CoV2Ag strain can be used to protect a subject in need thereof, against a challenge of Sars-CoV-2. DelNS1-B-Sars-CoV-2-CoV2Ag is an important strategy for making highly attenuated and immunogenic live attenuated vaccines with the ability to induce protective immunity against Sars-CoV-2.
Embodiments of the present invention provide a video timing motion nomination generation system and a method, which process, by means of an encoder, video features that are extracted from an inputted video so as to obtain video encoding features having global information, and extract corresponding segment features of interest from the video encoding features by means of a plurality of pre-trained nomination segments to provide to a decoder; the decoder generates segment features on the basis of the segment feature of interest corresponding to each nomination segment and a nomination feature corresponding to each pre-trained nomination segment, and provides same to a prediction module; and the prediction module generates a timing motion nomination result on the basis of the segment features from the decoder. The solution of the embodiments of the present invention can effectively capture global context information of a video and obtain video encoding features that have a stronger representation ability. Moreover, by introducing several learnable nomination segments to extract feature sequences of corresponding positions from the video encoding features for subsequent prediction, which improves training convergence speed and greatly reduces computational burden.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
82.
AN APPARATUS FOR DETECTING ENTRY AND EXIT BY CROSSING A VIRTUAL LINE
An entry/exit detection apparatus has two separate signal transmitters (T1,T2) with a signal blocking device (SBD) in-between them. Based on this apparatus, a virtual line (16) is established for detecting whether an object or a person (A) crossed the virtual line (16) and entered or exited from a place or vehicle which has the virtual line (16) at its entrance. The place may be a building, market, shop, restaurant, bank, school, lift (elevator), room, or car. When the object or person (A) with the portable device crosses this virtual line, the motion is detected by the detector monitoring signal from the two transmitters. The portable device will be able to detect and recognize it has crossed the virtual line automatically based on the signals received from these two signal transmitters.
CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Zhou, Jie
Chiu, Man Chun
Li, Cun
Yuen, Kwok Yong
Abrégé
Methods for obtaining a population of differentiated alveolar cells, differentiated alveolar cells in the form of alveolar organoids generated by the methods and uses for the differentiated alveolar organoids are provided. The methods include digesting long-term expanding lung organoids (LO) into single cells (i.e., dissociated cells), and suspension culturing the dissociated cells in distal differentiation (DD) cell culture media in a non-adherent plate for an effective amount of time. Alveolar organoids includes a population of AT1 and AT2 cells and in suspension culture exhibit an apical-out polarity and include abundant cytoplasmic lamellar bodies and microvilli. The alveolar organoids can be utilized alone or in combination with 2D and 3D AWO, rebuilt the human respiratory epithelium in culture plates for studying biology and pathology of human respiratory system, including, but not limited to, the study of COVID-19 respiratory diseases.
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions faisant intervenir des micro-organismes viables
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
84.
DEVELOPMENT OF SYNTHETIC PSEUDAMINIC ACID-BASED ANTIBACTERIAL VACCINES AGAINST ACINETOBACTER BAUMANNII
Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.
The present invention provides a video action detection method based on an end-to-end framework, and an electronic device. The end-to-end framework comprises a backbone network, a positioning module, and a classification module. The method comprises: performing, by the backbone network, feature extraction on a video clip to be detected to obtain a video feature map of said video clip, wherein the video feature map comprises feature maps of all frames in said video clip; extracting the feature map of a key frame from the video feature map by the backbone network, obtaining an actor location feature from the feature map of the key frame, and obtaining an action category feature from the video feature map; determining an actor location by the positioning module according to the actor location feature; and determining, by the classification module, the action category corresponding to the actor location according to the action category feature and the actor location. The video action detection method provided by the present invention is relatively low in complexity, and can achieve better detection performance.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
86.
SYSTEMS AND METHODS FOR MAGNETIC RESONANCE IMAGE RECONSTRUCTION FROM INCOMPLETE K-SPACE DATA
Disclosed are deep learning based methods for magnetic resonance imaging (MRI) image reconstruction from partial Fourier-space (i.e., k-space) data, involving: obtaining high-quality complex MRI image data or fully-sampled k-space data as training data; training reconstruction models to predict high-quality complex MRI image data or complete k-space data from incomplete or partial k-space data; and applying trained models to reconstruct high-quality complex MRI image data or complete k-space data from partial k-space data.
G01R 33/56 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne
G01R 33/561 - Amélioration ou correction de l'image, p.ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.à d. systèmes d'acquisition rapide, p.ex. utilisant des séquences d'impulsions écho-planar
87.
FABRICATION AND APPLICATION OF FIBER-BASED HYDROGEL USING ALL-AQUEOUS FORMULATIONS
Disclosed is a fiber-based hydrogel containing an aqueous hydrogel containing biocompatible microfibers having a high aspect ratio length to diameter suspended in water, the biocompatible microfibers mechanically interlocked. By simply adjusting the fiber aspect ratio, the fiber-based hydrogels can tune a considerable range of mechanical properties and drug release rates for clinical use. The fiber-based hydrogel has favorable biocompatibility and accelerated tissue regeneration ability demonstrated by a mice excision skin model.
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I):
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I):
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I):
In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
C07D 317/60 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p.ex. radicaux ester ou nitrile
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p.ex. éthers en couronne, guanadrel
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
A61K 31/4402 - Pyridines non condensées; Leurs dérivés hydrogénés substituées uniquement en position 2, p.ex. phéniramine, bisacodyl
A61K 31/4406 - Pyridines non condensées; Leurs dérivés hydrogénés substituées uniquement en position 3, p.ex. zimeldine
A61K 31/444 - Pyridines non condensées; Leurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. amrinone
A61K 31/4453 - Pipéridines non condensées, p.ex. pipérocaïne substituées uniquement en position 1, p.ex. propipocaïne, dipérodone
A61K 31/454 - Pipéridines non condensées, p.ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pimozide, dompéridone
A novel medical image generation approach synthesizes thin-cut computerized tomography (CT) images from thick-cut CT ones as inputs. First thick-cut CT images are obtained by maximizing the pixel-wise intensity of five or more than five continuous thin-cut ones after image registration. Second, the obtained thick-cut CT images are fed into a generator block which adopts an encoder-decoder architecture, where each thick-cut image is encoded into low-dimensional embedding space before decoding into multiple thin-cut ones. Third, a discriminator focuses on distinguishing original real thin-cut images from synthetic thin-cut images. An adversarial mechanism between the generator and discriminator causes the discriminator's output to provide an effective gradient update of the network parameters for the generator to increasingly improve the generator's ability to synthesize higher-quality thin-cut images and in turn promotes the discriminator's discriminating capability.
Disclosed is a three dimensional classification system for recognizing cross-sectional images automatically containing a processor that executes: rescaling a plurality of cross-sectional images, and feeding the rescaled plurality of cross-sectional images into two branches; feeding the rescaled plurality of cross-sectional images into a first branch for performing a plurality of convolutions on the rescaled plurality of cross-sectional images directly to learn features for distinguishing phases; feeding the rescaled plurality of cross-sectional images into a second branch for reducing resolution, then performing a plurality of convolutions on the reduced resolution plurality of cross-sectional images to learn features for distinguishing phases; and concatenating convolutional output channels from the two branches to fuse global and local features, on which two fully-connected layers are stacked as a classifier to recognize cross-sectional volumetric images accurately and quickly.
SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, DBA SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventeur(s)
Hui, Shu Yuen, Ron
Tan, Siew Chong
Mi, Chunting, Chris
Abrégé
Disclosed is a system for stabilizing a power distribution network. The network is supplied at least partially by a renewable energy source. The system comprises a bidirectional AC-DC power conversion system between a supply 5 side distribution network and a load side grid, for converting a supply side AC voltage, at a supply side frequency, to a load side DC voltage; a voltage regulator for regulating the load side DC voltage; and a supply side control loop comprising at least one of a frequency control loop and a voltage control loop for making a measurement of a respective one of the supply side frequency and 10 supply side AC voltage, and controlling bidirectional power transmission between the bidirectional AC-DC power conversion system and one or more DC loads connected to the load side grid, based on the measurement from the respective frequency control loop and/or voltage control loop.
H02J 3/18 - Dispositions pour réglage, élimination ou compensation de puissance réactive dans les réseaux
H02J 3/16 - Circuits pour réseaux principaux ou de distribution, à courant alternatif pour règler la tension dans des réseaux à courant alternatif par changement d'une caractéristique de la charge du réseau par réglage de puissance réactive
B60L 53/50 - Stations de charge caractérisées par des moyens d’emmagasinage ou de production d'énergie
92.
DINUCLEAR PLATINUM EMITTER COMPLEXES AND METHODS OF MAKING AND USING THEREOF
Described herein are dinuclear platinum (II) emitter complexes and their methods of making and using thereof. The design of the dinuclear platinum (II) emitters results in short radiative lifetimes and high quantum yields. The dinuclear platinum (II) emitter complexes can be used to fabricate blue emitting OLEDs.
Described herein are compounds containing palladium (II), as the central metal atom, and tetradentate [N^C^C^N] ligands. The compounds are charge neutral, and feature a donor-acceptor structure where a pendant substituted amino group (such as unsubstituted diphenylamine or substituted diphenylamine) and a heteroaryl group (such as pyridine group) serve as donor and acceptor, respectively. This donor-acceptor structure introduces a set of low-energy singlet and triplet charge-transfer excited states with small energy separation allowing for efficient thermally activated delayed fluorescence to take place.
C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 de la classification périodique
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
Platinum (II) complexes ( "Pt (II) complexes" ) that can emit in the red and/or deep red regions and methods of making and using thereof are described. These Pt (II) complexes can have dinuclearity with close Pt-Pt contact and close interplanar distance, allowing for high emission quantum yield, such as > 50%, short emission lifetime, such as < 3 μs, and high radiative decay rate, such as in the order of 10 5s -1. The Pt (II) complexes disclosed herein can be included in organic light-emitting devices, such as organic light-emitting diodes ( "OLEDs" ), for use in commercial applications. OLEDs containing these red-emitting Pt (II) complexes can have current efficiency and/or external quantum efficiency that are comparable or higher than commercially available red emitters and prolonged operational lifetime, such as a LT95 at 1000 nits >9000 h for a red OLED.
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
H01L 51/50 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED)
95.
DEVICES AND METHODS FOR ORIENTING A SURGICAL DEVICE
Devices and methods are provided that simplify and improve placement of stabilizing orthopedic pins, wires, and/or screws in the pelvis in minimally invasive surgery. Provided is a surgical instrument guide containing an adjustable friction clamp for positioning and securing a cannula, and a probe with a blunt, nonpenetrating tip. The probe and a surgical instrument held by the friction clamp are oriented at right angles to one another. In use, the blunt probe is introduced through a small incision and advanced by blunt dissection until the blunt tip is positioned at a desired anatomical landmark on the surface of the pelvis. A cannula inserted through the friction clamp is advanced until the tip of the cannula is within 2 cm of the blunt tip of the probe; an orthopedic pin, wire, and/or screw can then be inserted through the cannula to provide stabilization. The blunt probe may be cannulated.
The present invention can inhibit dihydrofolate reductase in a microorganism. In some aspects, it may also suppress pigment formation in gram negative bacteria. The suppression of pigment formation can also mediate virulence suppression on other Gram negative bacteria. As such, the compounds may be used for microbial infections. The compounds can potentiate the effects of one or more antimicrobial agents when co-administered. Compositions including the compounds are provided. The composition can further include at least one antibiotic.
A61K 31/427 - Thiazoles non condensés et contenant d'autres hétérocycles
A61K 31/7008 - Composés ayant un groupe amino lié directement à un atome de carbone du radical saccharide, p.ex. D-galactosamine, ranimustine
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p.ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p.ex. éthers en couronne, guanadrel
Described are fibula malleolus caps and surgery devices with fibula malleolus caps. The fibula malleolus caps may be patient-specific fibula malleolus caps. The devices with patient-specific fibula malleolus caps overcome the sliding and rotational errors during fibula flap harvesting. A comparative clinical study demonstrates that the fibula malleolus cap enhances the accuracy of fibula flap harvesting, leading to accurate location and angulation of simultaneous dental implants.
An electromechanical sensor and a method of sensing an object or a tactile input using the sensor. The sensor includes: a base provided with a magnetic sensor arranged to detect a change in magnetic flux at the position of the magnetic sensor; a flexible film adjacent to the magnetic sensor; and a magnetic element provided on the flexible film; wherein the magnetic element is arranged to move relative to the magnetic sensor when the flexible film is reversibly deformed by an external force applied to the flexible film.
G01R 33/06 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques
G01B 7/14 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer la distance ou la marge entre des objets ou des ouvertures espacés
G01B 7/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer les déformations dans un solide, p.ex. au moyen d'une jauge de contrainte à résistance en utilisant la variation des propriétés magnétiques
G01L 1/12 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés magnétiques d'un matériau, résultant de l'application d'un effort
G01V 3/08 - Prospection ou détection électrique ou magnétique; Mesure des caractéristiques du champ magnétique de la terre, p.ex. de la déclinaison ou de la déviation fonctionnant au moyen de champs magnétiques ou électriques produits ou modifiés par les objets ou les structures géologiques, ou par les dispositifs de détection
G01R 33/07 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs à effet Hall
G01D 5/14 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensible; Moyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminé; Transducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension
CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITED (Chine)
Inventeur(s)
Zhao, Hanjun
Yuen, Kwok-Yung
Abrégé
Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting in viral resistance. Preferably, the antiviral compositions contain P16 or a P16-like peptide which can both inhibit viral fusion and endosomal acidification to prevent viral entry through the endocytic pathway. The antiviral compositions can be used in methods of treating diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A (H1N1) pdm09 virus, avian influenza A (H7N9) virus, and the non-enveloped rhinovirus. The compositions are administered in a subject in need thereof in an effective amount to reduce or prevent viral replication in the subject, and thus reduce one or more symptoms of disease, disorder, or illness associated with virus.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p.ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p.ex. un fragment Fc
C07K 16/28 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A steerable arm (301) for use in endoscopic surgical procedures. The steerable arm (301) cut from a tube of nitinol to provide flexibility and resilience by the structure into which the tube is cut. Typically, the cut tube comprises a spiralling coil (707), the loops of which are in contact on one lateral side of the tube and the tube is bent to open apart the loops on the other lateral side. The material which the tube is made of is capable of retaining memory of the bend. This provides a bias for restoring the tube to the bend whenever a force causing the tube to flex is removed.
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p.ex. endoscopes; Dispositions pour l'éclairage dans ces instruments
G02B 23/24 - Instruments pour regarder l'intérieur de corps creux, p.ex. endoscopes à fibres
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