Systems and methods are disclosed for measuring the volume of liquid contained in a vessel. A sensor array comprising a plurality of sensors and a laser apparatus comprising one or more lasers can be positioned relative to each other such that lasers beams emitted from the laser(s) can be received by the sensor array. The vessel can be positioned such that each laser beam intersects the vessel at a certain predetermined height. A liquid level's height may be determined by the volume of liquid in the vessel. A refraction of a laser beam may be influenced by the presence or absence of liquid at that predetermined height, which could be the result of the liquid level's height being above or below that predetermined height. Readings from the sensor array may determine where refraction occurs, allowing ranges or values of the volume of liquid in the vessel to be extrapolated.
Systems and methods are disclosed for measuring the volume of liquid contained in a vessel. A sensor array comprising a plurality of sensors and a laser apparatus comprising one or more lasers can be positioned relative to each other such that lasers beams emitted from the laser(s) can be received by the sensor array. The vessel can be positioned such that each laser beam intersects the vessel at a certain predetermined height. A liquid level's height may be determined by the volume of liquid in the vessel. A refraction of a laser beam may be influenced by the presence or absence of liquid at that predetermined height, which could be the result of the liquid level's height being above or below that predetermined height. Readings from the sensor array may determine where refraction occurs, allowing ranges or values of the volume of liquid in the vessel to be extrapolated.
Surface-penetrating radar (SPR) is used to obtain images of a vehicle's undercarriage and employ these to identify the vehicle (or vehicle type or class). In particular, a vehicle may have a unique undercarriage SPR "signature" that remains largely stable over time, since it is not significantly affected by buildup of dirt, moisture or light debris. Even if the signature is not sufficiently differentiated from those of similar vehicles, it can be used to identify the vehicle within a class, which may be adequate for many purposes.
Surface-penetrating radar (SPR) systems provide localization information for provision to a blockchain application. SPR can be used in environments, such as cities, where multipath or shadowing degrades GPS accuracy, or as an alternative to optical sensing approaches that cannot tolerate darkness or changing scene illumination or whose performance can be adversely affected by variations in weather conditions. In particular, SPR can be used to acquire scans containing surface and subsurface features as a vehicle traverses terrain, and the acquired data scans may be compared to reference scan data that was previously acquired within the same environment in order to localize vehicle position within the environment. If the reference scan data has been labeled with geographic location information, a vehicle's absolute location can thereby be determined.
G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
7.
MONITORING VEHICLE LOCATION USING SURFACE-PENETRATING RADAR SYSTEMS AND BROADCAST TRANSMISSION
A location system utilizes a ground-penetrating radar (GPR) antenna array both to detect surface and subsurface road features as well as broadcast transmissions, which are used to improve localization. For example, the GPR antenna may pick up an AM or FM radio transmission or Wi-Fi signals, and may use these to calculate or refine the estimated position of the vehicle.
G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
G01S 13/60 - Velocity or trajectory determination systemsSense-of-movement determination systems wherein the transmitter and receiver are mounted on the moving object, e.g. for determining ground speed, drift angle, ground track
G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
G01C 21/00 - NavigationNavigational instruments not provided for in groups
8.
MONITORING VEHICLE MOTION USING SURFACE-PENETRATING RADAR SYSTEMS AND DOPPLER SHIFTS
Doppler analysis of surface-penetrating radar signals are utilized to compute or estimate parameters associated with vehicle motion. The Doppler shift may originate with reflections from subsurface or above-surface features ahead of (or behind) the moving vehicle, in which case a vehicle speed may be computed from the shift; or may originate with reflections from surface or subsurface features directly below the vehicle, in which case the shift corresponds to a vertical speed that may be used to sense the performance of, or changes in, the vehicle's suspension system.
G01S 13/60 - Velocity or trajectory determination systemsSense-of-movement determination systems wherein the transmitter and receiver are mounted on the moving object, e.g. for determining ground speed, drift angle, ground track
G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
Systems and methods for detecting oscillation of a trailer towed by a vehicle include implementing one or more SPR systems to acquire SPR information associated with the vehicle and/or the trailer and estimating a degree of swerve of the vehicle and/or a degree of lateral oscillation of the trailer based on the acquired SPR information.
G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
G01S 13/87 - Combinations of radar systems, e.g. primary radar and secondary radar
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
A system for navigating a vehicle on a terrain includes a surface-penetrating radar (SPR) system having one or more micro-antenna array having a full frequency range for acquiring real-time SPR information associated with the vehicle and one or more controllers configured to determine information associated with the terrain and/or the vehicle based at least in part on the acquired real-time SPR information. In various embodiments, the micro-antenna array(s) includes multiple micro-antenna elements, each being configured to operate at a frequency range, the frequency ranges of the micro-antenna elements collectively spanning the full frequency range greater than the frequency range of an individual one of the micro-antenna elements.
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
Deep learning to improve or gauge the performance of a surface-penetrating radar (SPR) system for localization or navigation. A vehicle may employ a terrain monitoring system including SPR for obtaining SPR signals as the vehicle travels along a route. An on-board computer including a processor and electronically stored instructions, executable by the processor, may analyze the acquired SPR images and computationally identify subsurface structures therein by using the acquired image as input to a predictor that has been computationally trained to identify subsurface structures in SPR images.
G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
G01S 13/931 - Radar or analogous systems, specially adapted for specific applications for anti-collision purposes of land vehicles
12.
IMPROVED NAVIGATION AND LOCALIZATION USING SURFACE-PENETRATING RADAR AND DEEP LEARNING
Deep learning to improve or gauge the performance of a surface-penetrating radar (SPR) system for localization or navigation. A vehicle may employ a terrain monitoring system including SPR for obtaining SPR signals as the vehicle travels along a route. An on- board computer including a processor and electronically stored instructions, executable by the processor, may analyze the acquired SPR images and computationally identify subsurface structures therein by using the acquired image as input to a predictor that has been computationally trained to identify subsurface structures in SPR images.
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
G01S 13/91 - Radar or analogous systems, specially adapted for specific applications for traffic control
G01C 21/00 - NavigationNavigational instruments not provided for in groups
One or more vehicles in a platoon may be operated autonomously using a surface-penetrating radar (SPR) system implemented in the lead vehicle. SPR signals obtained by the system may be converted to one or more images (or scans) that provide information about the ground surface and/or other surfaces around the vehicle within a detection range of the SPR system. Based on the obtained SPR signals, the lead vehicle may create a real-time map including the SPR information and/or localize the real-time SPR information to an existing map. This real-time SPR map information may then be transmitted from the lead vehicle to succeeding vehicles in the platoon in a pass-it-down fashion for localizing the succeeding vehicles behind the lead vehicle.
G05D 1/02 - Control of position or course in two dimensions
G05D 1/00 - Control of position, course, altitude or attitude of land, water, air or space vehicles, e.g. using automatic pilots
B60W 30/165 - Control of distance between vehicles, e.g. keeping a distance to preceding vehicle automatically following the path of a preceding lead vehicle, e.g. "electronic tow-bar"
Route planning is provided to a vehicle (or vehicle driver) based at least in part on the type of vehicle and the terrain conditions between the originating location and destination. The vehicle may employ a terrain monitoring system including a surface-penetrating radar (SPR) system for obtaining SPR signals as the vehicle travels along a route; the obtained SPR signals may be used for navigation against reference images associated with the route. In some embodiments, a navigation server bases route selection in part on the terrain associated with various routes and characteristics of the vehicle.
G01C 21/28 - NavigationNavigational instruments not provided for in groups specially adapted for navigation in a road network with correlation of data from several navigational instruments
G01C 21/20 - Instruments for performing navigational calculations
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the target analyte of interest. A vertex is interconnected with the bulk specimen reservoir to define a specimen chamber assembly to which a magnetic chamber is deployed about the vertex portion thereof and operative to sequester the magnetic particles, as well as any analyte of interest bound thereto, within the interior of the vertex. Once sufficient time is allowed for mixing and allowing the magnetic capsule to sufficiently retain the magnetic particles within the vertex, the vertex is disconnected from the specimen reservoir and the paramagnetic materials retained therein analyzed to determine the presence of the analyte of interest.
cell culture and cancer diagnostics tests, namely, liquid biopsy testing systems consisting of a specimen chamber assembly and magnetic materials used to sequester target analytes of interest within a liquid sample for isolation and characterization
cell culture and cancer diagnostics tests, namely, liquid biopsy testing systems consisting of a specimen chamber assembly and magnetic materials used to sequester target analytes of interest within a liquid sample for isolation and characterization
(1) Cell culture apparatus for medical use, namely, liquid biopsy testing system consisting of a specimen chamber assembly and magnetic materials used to sequester target analytes of interest within a liquid sample.
22.
SYSTEMS AND METHOD FOR SEQUESTERING SUBSTANCES IN BULK LIQUIDS
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the target analyte of interest. A vertex is interconnected with the bulk specimen reservoir to define a specimen chamber assembly to which a magnetic chamber is deployed about the vertex portion thereof and operative to sequester the magnetic particles, as well as any analyte of interest bound thereto, within the interior of the vertex. Once sufficient time is allowed for mixing and allowing the magnetic capsule to sufficiently retain the magnetic particles within the vertex, the vertex is disconnected from the specimen reservoir and the paramagnetic materials retained therein analyzed to determine the presence of the analyte of interest.
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/539 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent
23.
SYSTEMS AND METHOD FOR SEQUESTERING SUBSTANCES IN BULK LIQUIDS
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the target analyte of interest. A vertex is interconnected with the bulk specimen reservoir to define a specimen chamber assembly to which a magnetic chamber is deployed about the vertex portion thereof and operative to sequester the magnetic particles, as well as any analyte of interest bound thereto, within the interior of the vertex. Once sufficient time is allowed for mixing and allowing the magnetic capsule to sufficiently retain the magnetic particles within the vertex, the vertex is disconnected from the specimen reservoir and the paramagnetic materials retained therein analyzed to determine the presence of the analyte of interest.
B03C 1/10 - Magnetic separation acting directly on the substance being separated with cylindrical material carriers
C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/539 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent
24.
System and method for sequestering substances in bulk liquids
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid sample, along with paramagnetic materials operative to selectively bind to the target analyte of interest. A vertex is interconnected with the bulk specimen reservoir to define a specimen chamber assembly to which a magnetic chamber is deployed about the vertex portion thereof and operative to sequester the magnetic particles, as well as any analyte of interest bound thereto, within the interior of the vertex. Once sufficient time is allowed for mixing and allowing the magnetic capsule to sufficiently retain the magnetic particles within the vertex, the vertex is disconnected from the specimen reservoir and the paramagnetic materials retained therein analyzed to determine the presence of the analyte of interest.
Disclosed are methods to induce dislodgement of target prostatic cells from the prostate organ, collecting said cells, and subsequently examining the cell population. Such methods comprise the administration of an agent that facilitates the dislodgement of the target cells from within the prostate, which then migrate into the urethra. Exemplary agents include 5 alpha-reductase inhibitors. The cells induced to pass into the urethra are then collected non-invasively, such as through urine or semen samples. Such collection is further strategically calculated relative the administration of the agent so as to maximize the sample collection of the target cells of interest. The exfoliated prostatic epithelial cells are subsequently utilized for purposes such as detecting prostate cancer, predicting/measuring prostate tumor susceptibility to drug regimes, active surveillance of patients whose prostate biopsy results are negative, but continue to exhibit symptoms consistent with prostate cancer, and identifying false positive results associated with biomarker assays.
Disclosed are methods to induce dislodgement of target prostatic cells from the prostate organ, collecting said cells, and subsequently examining the cell population. Such methods comprise the administration of an agent that facilitates the dislodgement of the target cells from within the prostate, which then migrate into the urethra. Exemplary agents include 5 alpha-reductase inhibitors. The cells induced to pass into the urethra are then collected non-invasively, such as through urine or semen samples. Such collection is further strategically calculated relative the administration of the agent so as to maximize the sample collection of the target cells of interest. The exfoliated prostatic epithelial cells are subsequently utilized for purposes such as detecting prostate cancer, predicting/measuring prostate tumor susceptibility to drug regimes, active surveillance of patients whose prostate biopsy results are negative, but continue to exhibit symptoms consistent with prostate cancer, and identifying false positive results associated with biomarker assays.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
27.
PROSTATIC LIQUID BIOPSY FOR THE DETECTION OF PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA
Disclosed are methods to induce dislodgement of target prostatic cells from the prostate organ, collecting said cells, and subsequently examining the cell population. Such methods comprise the administration of an agent that facilitates the dislodgement of the target cells from within the prostate, which then migrate into the urethra. Exemplary agents include 5 alpha-reductase inhibitors. The cells induced to pass into the urethra are then collected non-invasively, such as through urine or semen samples. Such collection is further strategically calculated relative the administration of the agent so as to maximize the sample collection of the target cells of interest. The exfoliated prostatic epithelial cells are subsequently utilized for purposes such as detecting prostate cancer, predicting/measuring prostate tumor susceptibility to drug regimes, active surveillance of patients whose prostate biopsy results are negative, but continue to exhibit symptoms consistent with prostate cancer, and identifying false positive results associated with biomarker assays.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
magnetic chromatography assays for the detection of cancerous cells diagnostic kits consisting of chemical reagents and modified microscope slides for the purpose of detecting cancerous cells
Cell culture apparatus for medical use, namely, liquid biopsy testing system consisting of a specimen chamber assembly and magnetic materials used to sequester target analytes of interest within a liquid sample
