Abstract

A bone regeneration material containing a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, and a solid synthetic second phase of calcium phosphate intended to enrich the first phase and having a Ca/P molar ratio of between 0.2 and 2 is provided. The bone regeneration material has a defined weight ratio of the solid first phase of hydroxyapatite of natural origin to the solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

IPC Classes  ?

• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/56 - Porous or cellular materials

Abstract

The present invention relates to a bone regeneration material consisting essentially of a solid phase of hydroxyapatite of macroporous natural origin, as well as to a method for manufacturing same and to a method for repairing a bone defect.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• C04B 35/447 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on phosphates

Abstract

The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 μm, this phase of hydroxyapatite is a crystalline solid phase of hydroxyapatite, whose crystals have a size comprised between 20 and 120 nm, and this solid phase of hydroxyapatite has a specific surface area comprised between 8 and 20 m2/g, the method of production and a method of bone repair based on this bone regeneration material.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61F 2/28 - Bones

Abstract

The present invention relates to a covering device arranged to promote bone regeneration of a bone defect site, which is obtained by additive manufacturing and comprises at least one shell formed of a porous matrix, and to a method for producing same.

IPC Classes  ?

• A61F 2/28 - Bones
• A61F 2/30 - Joints
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/38 - Animal cells
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, preferably pores of diameters between 50 and 100 pm, and a solid synthetic second phase of calcium phosphate intended to enrich said first phase, said second phase having a Ca/P molar ratio of between 0.2 and 2, preferably of between 0.3 and 1.9, preferentially of between 0.5 and 1.65, said bone regeneration material having a defined weight ratio of said solid first phase of hydroxyapatite of natural origin to said solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

IPC Classes  ?

• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/56 - Porous or cellular materials

Abstract

The present invention relates to a bone regeneration material comprising:-a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, preferably pores of diameters between 50 and 100 pm, and - a solid synthetic second phase of calcium phosphate intended to enrich said first phase, said second phase having a Ca/P molar ratio of between 0.2 and 2, preferably of between 0.3 and 1.8, preferentially of between 0.5 and 1.65, said bone regeneration material having a defined weight ratio of said solid first phase of hydroxyapatite of natural origin to said solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/56 - Porous or cellular materials

Abstract

Described herein is a method that comprises: —placing a bone material, containing hydroxyapatite and organic substances, in contact with an extraction liquid that gives rise to a first liquid phase, containing the organic substances and possibly impurities extracted from the bone material, and a second solid hydroxyapatite phase, containing the hydroxyapatite; and —separating the liquid phase and the solid hydroxyapatite phase. The extraction liquid is an aqueous extraction solution brought to a temperature between 150° C. and 300° C. and a pressure between 150 kPa and 350 kPa.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials

Abstract

The invention relates to a method that includes: - placing a bone material, containing hydroxyapatite and organic substances, in contact with an extraction liquid that gives rise to a first liquid phase, containing said organic substances and possibly impurities extracted from said bone material, and a second solid hydroxyapatite phase, containing said hydroxyapatite; and - separating said liquid phase and said solid hydroxyapatite phase. Said extraction liquid is an aqueous extraction solution brought to a temperature between 150°C and 300°C and a pressure between 150 kPa and 350 kPa.

IPC Classes  ?

• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof