Abrégé

A bone regeneration material containing a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, and a solid synthetic second phase of calcium phosphate intended to enrich the first phase and having a Ca/P molar ratio of between 0.2 and 2 is provided. The bone regeneration material has a defined weight ratio of the solid first phase of hydroxyapatite of natural origin to the solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

Classes IPC  ?

• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/56 - Matériaux poreux ou cellulaires

Abrégé

The present invention relates to a bone regeneration material consisting essentially of a solid phase of hydroxyapatite of macroporous natural origin, as well as to a method for manufacturing same and to a method for repairing a bone defect.

Classes IPC  ?

• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/38 - Cellules animales
• C04B 35/447 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base de phosphates

Abrégé

The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 μm, this phase of hydroxyapatite is a crystalline solid phase of hydroxyapatite, whose crystals have a size comprised between 20 and 120 nm, and this solid phase of hydroxyapatite has a specific surface area comprised between 8 and 20 m2/g, the method of production and a method of bone repair based on this bone regeneration material.

Classes IPC  ?

• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61F 2/28 - Os

Abrégé

The present invention relates to a covering device arranged to promote bone regeneration of a bone defect site, which is obtained by additive manufacturing and comprises at least one shell formed of a porous matrix, and to a method for producing same.

Classes IPC  ?

• A61F 2/28 - Os
• A61F 2/30 - Articulations
• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/38 - Cellules animales
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
• B33Y 80/00 - Produits obtenus par fabrication additive

Abrégé

The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, preferably pores of diameters between 50 and 100 pm, and a solid synthetic second phase of calcium phosphate intended to enrich said first phase, said second phase having a Ca/P molar ratio of between 0.2 and 2, preferably of between 0.3 and 1.9, preferentially of between 0.5 and 1.65, said bone regeneration material having a defined weight ratio of said solid first phase of hydroxyapatite of natural origin to said solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

Classes IPC  ?

• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/56 - Matériaux poreux ou cellulaires

Abrégé

The present invention relates to a bone regeneration material comprising:-a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, preferably pores of diameters between 50 and 100 pm, and - a solid synthetic second phase of calcium phosphate intended to enrich said first phase, said second phase having a Ca/P molar ratio of between 0.2 and 2, preferably of between 0.3 and 1.8, preferentially of between 0.5 and 1.65, said bone regeneration material having a defined weight ratio of said solid first phase of hydroxyapatite of natural origin to said solid synthetic second phase of calcium phosphate of between 99/1 and 1/99.

Classes IPC  ?

• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/56 - Matériaux poreux ou cellulaires

Abrégé

Described herein is a method that comprises: —placing a bone material, containing hydroxyapatite and organic substances, in contact with an extraction liquid that gives rise to a first liquid phase, containing the organic substances and possibly impurities extracted from the bone material, and a second solid hydroxyapatite phase, containing the hydroxyapatite; and —separating the liquid phase and the solid hydroxyapatite phase. The extraction liquid is an aqueous extraction solution brought to a temperature between 150° C. and 300° C. and a pressure between 150 kPa and 350 kPa.

Classes IPC  ?

• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 27/56 - Matériaux poreux ou cellulaires

Abrégé

The invention relates to a method that includes: - placing a bone material, containing hydroxyapatite and organic substances, in contact with an extraction liquid that gives rise to a first liquid phase, containing said organic substances and possibly impurities extracted from said bone material, and a second solid hydroxyapatite phase, containing said hydroxyapatite; and - separating said liquid phase and said solid hydroxyapatite phase. Said extraction liquid is an aqueous extraction solution brought to a temperature between 150°C and 300°C and a pressure between 150 kPa and 350 kPa.

Classes IPC  ?

• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels