BioSig Technologies, Inc.

United States of America

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2026 July 1
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IPC Class
A61B 5/00 - Measuring for diagnostic purposes Identification of persons 26
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body 17
A61B 18/14 - Probes or electrodes therefor 17
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation 17
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body 16
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NICE Class
09 - Scientific and electric apparatus and instruments 7
10 - Medical apparatus and instruments 4
35 - Advertising and business services 1
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44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services 1
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1.

APPARATUS AND METHODS FOR REMOVING A LARGE-SIGNAL VOLTAGE OFFSET FROM A BIOMEDICAL SIGNAL

      
Application Number 19445237
Status Pending
Filing Date 2026-01-09
First Publication Date 2026-07-16
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/339 - Displays specially adapted therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • A61B 5/33 - Heart-related electrical modalities, e.g. electrocardiography [ECG] specially adapted for cooperation with other devices
  • A61B 5/346 - Analysis of electrocardiograms
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • A61B 18/14 - Probes or electrodes therefor
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03H 17/02 - Frequency-selective networks
  • H03K 5/125 - Discriminating pulses
  • H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling

2.

Pacing Artifact Removal

      
Application Number 18459728
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-08-15
Owner BioSig Technologies, Inc. (USA)
Inventor Foxall, Thomas G.

Abstract

Disclosed herein are system, method, and computer-readable medium aspects for removing and detecting pacing artifacts from electrocardiogram and cardiac electrogram signals. An aspect includes a circuit board. The circuit board comprises two signal paths configured to receive a signal comprising cardiac data, pacing data, and background electrical noise. The first path comprises a first filter configured to amplify the cardiac data of the signal and suppress the pacing data of the signal. The second path comprises a second filter configured to amplify the pacing data of the signal and suppress the cardiac data of the signal. The circuit board also comprises a thresholding generator configured to establish a threshold amplitude value. The circuit board further comprises a thresholding module configured to apply the threshold amplitude value to the signal, thereby removing parts of amplitude of the signal that are less than or equal to the threshold amplitude value.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

3.

ELIMINATION OF NEGATIVE COMPONENT OF UNIPOLAR ATRIAL ELECTROGRAM AND SIGNALING OF SAME

      
Application Number 18459715
Status Pending
Filing Date 2023-09-01
First Publication Date 2024-07-25
Owner BioSig Technologies, Inc. (USA)
Inventor Koch, Zachary W.

Abstract

Disclosed herein are system and method aspects for monitoring changes in a negative component of a unipolar electrogram. The system can include a memory and at least one processor coupled to the memory. The at least one processor can be configured to receive a unipolar electrogram signal from a catheter, display on at least one digital display a signal waveform based on the unipolar electrogram signal using a first attribute. The signal waveform can represent one or more cycles from a patient's heart. The at least one processor can also be configured to monitor the signal waveform to detect a change in a negative component of the unipolar electrogram signal and to signal the change on the at least one digital display when the change is detected in at least a threshold number of consecutive cycles.

IPC Classes  ?

  • A61B 5/339 - Displays specially adapted therefor
  • A61B 5/349 - Detecting specific parameters of the electrocardiograph cycle

4.

PACING ARTIFACT REMOVAL

      
Application Number US2023031839
Publication Number 2024/054409
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-14
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor Foxall, Thomas G.

Abstract

Disclosed herein are system, method, and computer-readable medium aspects for removing and detecting pacing artifacts from electrocardiogram and cardiac electrogram signals. An aspect includes a circuit board. The circuit board comprises two signal paths configured to receive a signal comprising cardiac data, pacing data, and background electrical noise. The first path comprises a first filter configured to amplify the cardiac data of the signal and suppress the pacing data of the signal. The second path comprises a second filter configured to amplify the pacing data of the signal and suppress the cardiac data of the signal. The circuit board also comprises a thresholding generator configured to establish a threshold amplitude value. The circuit board further comprises a thresholding module configured to apply the threshold amplitude value to the signal, thereby removing parts of amplitude of the signal that are less than or equal to the threshold amplitude value.

IPC Classes  ?

  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

5.

Universal notch filter

      
Application Number 18084034
Grant Number 11843407
Status In Force
Filing Date 2022-12-19
First Publication Date 2023-07-06
Grant Date 2023-12-12
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for removing any fixed frequency interfering signal from an input signal without introducing artifacts that are not part of the original signal of interest. An embodiment operates by using a virtual buffer with a length that matches a length of one cycle of an interfering signal. The embodiment extracts the interfering signal into the virtual buffer. For a sample in the next cycle of the interfering signal that corresponds to a virtual memory location for the virtual buffer, the embodiment can update one or more physical memory locations of the virtual buffer that are in the vicinity of the virtual memory location. This use of virtual buffer can remove any interfering signal without creating the artifacts associated with conventional notch filters.

IPC Classes  ?

  • H04B 1/10 - Means associated with receiver for limiting or suppressing noise or interference
  • H04B 1/04 - Circuits

6.

Universal notch filter

      
Application Number 17591008
Grant Number 11569853
Status In Force
Filing Date 2022-02-02
First Publication Date 2022-08-18
Grant Date 2023-01-31
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for removing any fixed frequency interfering signal from an input signal without introducing artifacts that are not part of the original signal of interest. An embodiment operates by using a virtual buffer with a length that matches a length of one cycle of an interfering signal. The embodiment extracts the interfering signal into the virtual buffer. For a sample in the next cycle of the interfering signal that corresponds to a virtual memory location for the virtual buffer, the embodiment can update one or more physical memory locations of the virtual buffer that are in the vicinity of the virtual memory location. This use of virtual buffer can remove any interfering signal without creating the artifacts associated with conventional notch filters.

IPC Classes  ?

  • H04B 1/10 - Means associated with receiver for limiting or suppressing noise or interference
  • H04B 1/04 - Circuits

7.

Systems and methods for performing electrophysiology (EP) signal processing

      
Application Number 17719866
Grant Number 11737699
Status In Force
Filing Date 2022-04-13
First Publication Date 2022-08-11
Grant Date 2023-08-29
Owner
  • BioSig Technologies, Inc. (USA)
  • Mayo Foundation for Medical Education and Research (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.

IPC Classes  ?

  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

8.

Apparatus and methods for removing a large-signal voltage offset from a biomedical signal

      
Application Number 17584076
Grant Number 11617530
Status In Force
Filing Date 2022-01-25
First Publication Date 2022-08-04
Grant Date 2023-04-04
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

9.

Apparatus and methods for removing a large-signal voltage offset from a biomedical signal

      
Application Number 17477213
Grant Number 11617529
Status In Force
Filing Date 2021-09-16
First Publication Date 2022-04-14
Grant Date 2023-04-04
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/30 - Input circuits therefor
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

10.

METHODS, SYSTEMS AND MEDIA FOR DETRENDING BIOELECTRIC SIGNALS

      
Application Number US2021047524
Publication Number 2022/046886
Status In Force
Filing Date 2021-08-25
Publication Date 2022-03-03
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Wissner-Gross, Alexander David
  • Kapa, Suraj
  • Lee, James Y.
  • Keenan, Desmond B.
  • Drapeau, Natasha
  • Londoner, Kenneth L.
  • Stephenson, Julie M.
  • Chaudoir, Olivier P.

Abstract

Methods, systems, and media are disclosed for detrending a bioelectric signal. In some embodiments, the disclosed system can include a processor configured to receive the bioelectric signal, identify at least one breakpoint section corresponds to a rapid change of amplitude of the bioelectric signal, smooth an amplitude of the bioelectric signal after the at least one breakpoint section; and reconstruct the bioelectric signal based on the smoothed amplitude of the bioelectric signal and a reset of the breakpoint section to remove extrinsic components caused by a non-biological factor from the bioelectric signal

IPC Classes  ?

  • A61B 5/346 - Analysis of electrocardiograms
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

11.

Controlled switching network for electrophysiology procedures

      
Application Number 16987552
Grant Number 11911087
Status In Force
Filing Date 2020-08-07
First Publication Date 2022-02-10
Grant Date 2024-02-27
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Foxall, Thomas G.
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Vlajinic, Branislav

Abstract

Described herein are embodiments of a switching network for integrating electrophysiology components into an electrophysiology system. These electrophysiology components may include electrophysiology recorder, three-dimensional mapping systems, radio frequency generators, and stimulators. The switching network provides switchable connections, which allow the electrophysiology system to be reconfigured to perform different electrophysiology procedures, such as heart signal recording and mapping, cardiac ablation, or cardiac pacing. A recorder may provide control signals to the switching network to change connections between electrophysiology equipment and a catheter in a patient's heart. The electrophysiology system may control generation of biphasic pulses for use in cardiac pacing. The electrophysiology system may reconfigure the effective size the tip electrode of a split tip catheter.

IPC Classes  ?

  • A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

12.

Methods, systems and media for reconstructing bioelectronic lead placement

      
Application Number 17240809
Grant Number 11737701
Status In Force
Filing Date 2021-04-26
First Publication Date 2021-11-11
Grant Date 2023-08-29
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Wissner-Gross, Alexander David
  • Kapa, Suraj
  • Lee, James Y.
  • Keenan, Desmond B.
  • Drapeau, Natalia
  • Londoner, Kenneth L.

Abstract

Methods, systems, and media are disclosed for reconstructing bioelectronic lead placement. In some embodiments, the disclosed system can include a processor configured to determine relationships between EP signals of one or more pairs of a plurality of electrodes over one or more sampling time periods, wherein the plurality electrodes are separately placed on a patient's body for collecting the EP signals, and to reconstruct geometry of the plurality of electrodes based on the relationships between the EP signals.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/349 - Detecting specific parameters of the electrocardiograph cycle
  • A61B 5/389 - Electromyography [EMG]
  • A61B 5/327 - Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads

13.

SHOWING THE WAY TO BETTER.

      
Serial Number 90738872
Status Pending
Filing Date 2021-05-27
Owner BioSig Technologies, Inc. ()
NICE Classes  ?
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

Medical instruments in the nature of computer hardware and downloadable computer software for transmitting and monitoring electrical pulses for assisting electrophysiologists during electrophysiology research studies, for performing cardiac ablations, and for diagnosis of arrhythmia; Recorded computer software for reviewing and analyzing data, algorithms, and signals in the field of cardiac electrophysiology; Recorded computer software, namely, a software module used in an electrophysiology navigation and ablation system for cardiac electrophysiology Medical instruments for assisting electrophysiologists during electrophysiology cardiac research studies, for performing cardiac ablations, and for diagnosis of arrhythmia; Medical device, apparatus, and instruments for use in sensing, acquiring, digitizing, amplifying, filtering, measuring, calculating, analyzing, diagnosing, displaying, recording, and storing biomedical data, algorithms and signals in the fields of cardiology, neurology, nephrology, cognitive disorders and chronic pain

14.

UNIVERSAL NOTCH FILTER

      
Application Number US2020059372
Publication Number 2021/092352
Status In Force
Filing Date 2020-11-06
Publication Date 2021-05-14
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for removing any fixed frequency interfering signal from an input signal without introducing artifacts that are not part of the original signal of interest. An embodiment operates by using a virtual buffer with a length that matches a length of one cycle of an interfering signal. The embodiment extracts the interfering signal into the virtual buffer. For a sample in the next cycle of the interfering signal that corresponds to a virtual memory location for the virtual buffer, the embodiment can update one or more physical memory locations of the virtual buffer that are in the vicinity of the virtual memory location. This use of virtual buffer can remove any interfering signal without creating the artifacts associated with conventional notch filters.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • H03H 17/02 - Frequency-selective networks
  • G10L 21/0208 - Noise filtering
  • G10L 21/0224 - Processing in the time domain
  • H04B 1/10 - Means associated with receiver for limiting or suppressing noise or interference
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • G06F 5/10 - Methods or arrangements for data conversion without changing the order or content of the data handled for changing the speed of data flow, i.e. speed regularising having a sequence of storage locations each being individually accessible for both enqueue and dequeue operations, e.g. using random access memory

15.

Universal notch filter

      
Application Number 17091357
Grant Number 11265031
Status In Force
Filing Date 2020-11-06
First Publication Date 2021-05-13
Grant Date 2022-03-01
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for removing any fixed frequency interfering signal from an input signal without introducing artifacts that are not part of the original signal of interest. An embodiment operates by using a virtual buffer with a length that matches a length of one cycle of an interfering signal. The embodiment extracts the interfering signal into the virtual buffer. For a sample in the next cycle of the interfering signal that corresponds to a virtual memory location for the virtual buffer, the embodiment can update one or more physical memory locations of the virtual buffer that are in the vicinity of the virtual memory location. This use of virtual buffer can remove any interfering signal without creating the artifacts associated with conventional notch filters.

IPC Classes  ?

  • H04B 1/10 - Means associated with receiver for limiting or suppressing noise or interference
  • H04B 1/04 - Circuits

16.

Apparatus for processing biomedical signals for display

      
Application Number 17130842
Grant Number 11229391
Status In Force
Filing Date 2020-12-22
First Publication Date 2021-04-15
Grant Date 2022-01-25
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

17.

WCT+

      
Application Number 018432230
Status Registered
Filing Date 2021-03-18
Registration Date 2021-07-23
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Computer hardware featuring preinstalled signal processing technology software for diagnosing and treating sympathetic nervous system disorders, cardiovascular diseases, nephrological diseases, cognitive disorders, and chronic pain.

18.

ACCUVIZ

      
Application Number 018432231
Status Registered
Filing Date 2021-03-18
Registration Date 2021-07-15
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Recorded software for reviewing and analyzing data, algorithms, and signals in the field of cardiac electrophysiology; recorded computer software, namely, a software module used in an electrophysiology navigation and ablation system for cardiac electrophysiology.

19.

COMBIO

      
Application Number 018427746
Status Registered
Filing Date 2021-03-15
Registration Date 2021-07-15
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Recorded software for reviewing and analyzing data, algorithms, and signals in the field of cardiac electrophysiology; recorded computer software, namely, a software module used in an electrophysiology navigation and ablation system for cardiac electrophysiology.

20.

Systems and methods for performing electrophysiology (EP) signal processing

      
Application Number 17082564
Grant Number 11045133
Status In Force
Filing Date 2020-10-28
First Publication Date 2021-02-11
Grant Date 2021-06-29
Owner
  • BioSig Technologies, Inc. (USA)
  • Mayo Foundation for Medical Education and Research (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for filtering noise from an input signal. An embodiment accesses the input signal having a first harmonic frequency and having the noise. The embodiment determines a quiet period in the input signal. The embodiment stores samples of the noise of the input signal in a buffer during the quiet period. The embodiment subtracts the samples from a single cycle of the noise in the buffer from the input signal to create a filtered signal. The embodiment then repeats the determining, storing, and subtracting to refine the filtered signal.

IPC Classes  ?

  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

21.

Apparatus and methods for removing a large-signal voltage offset from a biomedical signal

      
Application Number 17065566
Grant Number 11123003
Status In Force
Filing Date 2020-10-08
First Publication Date 2021-01-28
Grant Date 2021-09-21
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • H03K 5/125 - Discriminating pulses
  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

22.

WCT+

      
Serial Number 90271584
Status Registered
Filing Date 2020-10-22
Registration Date 2024-02-20
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 09 - Scientific and electric apparatus and instruments

Goods & Services

Computer hardware featuring preinstalled signal processing technology software for diagnosing and treating sympathetic nervous system disorders, cardiovascular diseases, nephrological diseases, cognitive disorders, and chronic pain

23.

Apparatus for processing biomedical signals for display

      
Application Number 16866195
Grant Number 10911365
Status In Force
Filing Date 2020-05-04
First Publication Date 2020-08-20
Grant Date 2021-02-02
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body

24.

Apparatus and methods for removing a large- signal voltage offset from a biomedical signal

      
Application Number 16718996
Grant Number 10841232
Status In Force
Filing Date 2019-12-18
First Publication Date 2020-04-23
Grant Date 2020-11-17
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body

25.

Systems and methods for signal acquisition and visualization

      
Application Number 16661433
Grant Number 10986033
Status In Force
Filing Date 2019-10-23
First Publication Date 2020-02-20
Grant Date 2021-04-20
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, apparatus, and methods are disclosed for processing biomedical signals. An electrophysiology (EP) system includes a differential circuit to process the biomedical signals; a differential amplifier circuit to amplify an output of the differential circuit; an analog-to-digital converter to digitize an output of the differential amplifier circuit; a communication module to interface between the analog-to-digital converter and a digital processing stage having a plurality of signal modules; and at least one processor to execute the plurality of signal modules, applying digital signal processing to the output from the analog-to-digital converter, to extract features of interest of the biomedical signals.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/30 - Input circuits therefor
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

26.

Systems and methods for performing electrophysiology (EP) signal processing

      
Application Number 16584167
Grant Number 10708191
Status In Force
Filing Date 2019-09-26
First Publication Date 2020-01-23
Grant Date 2020-07-07
Owner
  • BioSig Technologies, Inc. (USA)
  • Mayo Foundation for Medical Education and Research (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The embodiment further includes a communications interface communicatively coupled to a remote device, and a processor, coupled to the ECG circuit board, the plurality of IC circuit boards, and the communications interface. The processor is configured to receive, via the communications interface, feedback from the remote device. The processor is further configured to control, via the communication interface, the remote device based on the ECG signal, the IC signals, or the feedback from the remote device.

IPC Classes  ?

  • A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body

27.

Systems and methods for performing electrophysiology (EP) signal processing

      
Application Number 16582927
Grant Number 11324431
Status In Force
Filing Date 2019-09-25
First Publication Date 2020-01-16
Grant Date 2022-05-10
Owner
  • BioSig Technologies, Inc. (USA)
  • Mayo Foundation for Medical Education and Research (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.

IPC Classes  ?

  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

28.

Systems and methods to display cardiac signals based on a signal pattern

      
Application Number 16543061
Grant Number 11896379
Status In Force
Filing Date 2019-08-16
First Publication Date 2019-12-05
Grant Date 2024-02-13
Owner
  • BioSig Technologies, Inc. (USA)
  • Mayo Foundation for Medical Education and Research (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for displaying cardiac signals based on a signal pattern. An embodiment operates by accessing an input cardiac signal. The embodiment matches a portion of the input cardiac signal to a known signal pattern. The embodiment then displays an indication of a degree of the match.

IPC Classes  ?

  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/30 - Input circuits therefor
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
  • A61B 5/308 - Input circuits therefor specially adapted for particular uses for electrocardiography [ECG]
  • H04L 43/02 - Capturing of monitoring data
  • H04L 47/50 - Queue scheduling
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/45 - Differential amplifiers
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • H03K 5/125 - Discriminating pulses
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 5/361 - Detecting fibrillation
  • A61B 5/363 - Detecting tachycardia or bradycardia
  • A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening

29.

SYSTEMS AND METHODS FOR SIGNAL ACQUISITION AND VISUALIZATION

      
Application Number US2019031433
Publication Number 2019/217621
Status In Force
Filing Date 2019-05-09
Publication Date 2019-11-14
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus, methods, and systems relate to an electrophysiology (EP) recording system for acquisition and preservation of cardiac electrical signals. The EP recording system provides defibrillator protection and radio frequency (RF) ablation signal noise suppression while preserving the integrity of relevant components of raw small signals. The EP recording system has a low-noise amplifier topology with minimal hardware filtering and a high-resolution A/D converter that provides clean, raw digital signals. The raw signals are filtered and processed by the EP system using software-based digital signal processing algorithms that allow the real-time display of signals as a raw signal, or as a combination of raw and processed signals simultaneously, in a single window or in multiple windows. The EP recording system allows for the synchronized display of signals with more than one signal processing algorithm applied at the same time, allowing a user to study signals filtered for specific purposes.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0402 - Electrocardiography, i.e. ECG

30.

SYSTEMS AND METHODS TO DISPLAY SIGNALS BASED ON A SIGNAL CHARACTERISTIC

      
Application Number US2019031434
Publication Number 2019/217622
Status In Force
Filing Date 2019-05-09
Publication Date 2019-11-14
Owner
  • BIOSIG TECHNOLOGIES, INC. (USA)
  • MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav
  • Asirvatham, Samuel J.

Abstract

Systems, methods, and computer program product embodiments are disclosed for displaying signals based on a signal characteristic, such as a late potential or an early activation. An embodiment operates by matching, by a first digital signal processor (DSP) of a first signal module, a beat in a first packet associated with a first cardiac signal to a known signal characteristic. The embodiment also searches, by a second DSP of a second signal module, for the signal characteristic in a second packet associated with a second cardiac signal in response to the matching. The embodiment displays, by a display module coupled to the first signal module and the second signal module, a portion of the first cardiac signal. The embodiment then displays, by the display module, a portion of the second cardiac signal comprising the signal characteristic time-synchronized to the displayed portion of the first cardiac signal based on the searching.

IPC Classes  ?

  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

31.

Systems and methods for signal acquisition and visualization

      
Application Number 16271466
Grant Number 10485485
Status In Force
Filing Date 2019-02-08
First Publication Date 2019-11-14
Grant Date 2019-11-26
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, apparatus, and methods are disclosed for bi-directionally conveying biomedical signals between a patient and signal acquisition and processing devices. An electrophysiology (EP) system includes an analog input protection and filtering stage with a differential circuit to process the biomedical signals to and from the patient; a signal amplification stage with a differential amplifier circuit to amplify an output of the differential circuit; an analog-to-digital converter stage to digitize an output of the differential amplifier circuit; a communication module to interface between the analog-to-digital converter stage and a digital processing stage having a plurality of signal modules; at least one processor to execute the plurality of signal modules, applying frequency-selective filtering and signal processing algorithms to the output from the analog-to-digital converter stage, to extract high-frequency and low-amplitude features of the biomedical signals in frequency ranges of interest; and a display for pattern- and time-aligned visualization of the biomedical signals.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

32.

Systems and methods to visually align signals using delay

      
Application Number 16447275
Grant Number 10924424
Status In Force
Filing Date 2019-06-20
First Publication Date 2019-11-14
Grant Date 2021-02-16
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for processing and displaying multiple signals in near real-time. An embodiment operates by processing, using a first digital signal processor (DSP) of a first signal module, a first packet associated with a first signal. The embodiment also processes, using a second DSP of a second signal module, a second packet associated with a second signal. The embodiment equalizes a first processing delay associated with the first DSP with a second processing delay associated with the second DSP such that the first DSP completes processing of the first packet approximately simultaneously with the second DSP completing processing of the second packet. The embodiment then displays the processed first packet approximately simultaneously with the display of the processed second packet.

IPC Classes  ?

  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • H03H 17/02 - Frequency-selective networks
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/0538 - Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter

33.

Apparatus and methods for removing a large-signal voltage offset from a biomedical signal

      
Application Number 16195562
Grant Number 10686715
Status In Force
Filing Date 2018-11-19
First Publication Date 2019-11-14
Grant Date 2020-06-16
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body

34.

Systems, apparatus, and methods for conveying biomedical signals between a patient and monitoring and treatment devices

      
Application Number 16195573
Grant Number 10645017
Status In Force
Filing Date 2018-11-19
First Publication Date 2019-11-14
Grant Date 2020-05-05
Owner BioSig Technologies, Inc. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, apparatus, and methods are disclosed for conveying signals between a patient and monitoring and treatment devices. An EP system provides large-signal input protection and RF ablation signal noise suppression while preserving the integrity of relevant components of small signals. The EP system has a low-noise amplifier topology with minimal hardware filtering. An input protection circuit shunts to ground signals with amplitude above an ablation voltage. An RF filter circuit linearly attenuates the signals between 300 kHz and 600 kHz. A low-frequency feedback circuit drives a common mode node of the RF filter circuit for additional attenuation. A signal amplification circuit amplifies the signals between 0.01 Hz and 1000 Hz. A fast recovery circuit feeds back a low-frequency voltage signal to the signal amplification circuit to gradually reduce offset voltage of the signals. A high-resolution A/D converter converts the signals from the signal amplification circuit to clean digital signals.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • A61B 5/0428 - Input circuits specially adapted therefor
  • H03F 3/45 - Differential amplifiers
  • H03K 5/125 - Discriminating pulses
  • A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
  • A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
  • A61B 5/046 - Detecting fibrillation
  • A61B 5/0464 - Detecting tachycardia or bradycardia
  • A61B 18/14 - Probes or electrodes therefor
  • A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
  • H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
  • H03F 3/68 - Combinations of amplifiers, e.g. multi-channel amplifiers for stereophonics
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/0456 - Detecting R peaks, e.g. for synchronising diagnostic apparatus
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body

35.

Display screen or portion thereof with graphical user interface

      
Application Number 29659191
Grant Number D0864980
Status In Force
Filing Date 2018-08-07
First Publication Date 2019-10-29
Grant Date 2019-10-29
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

36.

Display screen or portion thereof with graphical user interface

      
Application Number 29647055
Grant Number D0864229
Status In Force
Filing Date 2018-05-09
First Publication Date 2019-10-22
Grant Date 2019-10-22
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

37.

Display screen or portion thereof with graphical user interface

      
Application Number 29659195
Grant Number D0864237
Status In Force
Filing Date 2018-08-07
First Publication Date 2019-10-22
Grant Date 2019-10-22
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

38.

SEE MORE, CLEARLY

      
Serial Number 88644374
Status Registered
Filing Date 2019-10-07
Registration Date 2023-04-04
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ?
  • 09 - Scientific and electric apparatus and instruments
  • 10 - Medical apparatus and instruments

Goods & Services

Medical instruments in the nature of computer hardware and downloadable computer software for transmitting and monitoring electrical pulses for assisting electrophysiologists during electrophysiology research studies, for performing cardiac ablations, and for diagnosis of arrhythmia Medical instruments for assisting electrophysiologists during electrophysiology cardiac research studies, for performing cardiac ablations, and for diagnosis of arrhythmia; medical device, apparatus, and instruments for use in sensing, acquiring, digitizing, amplifying, filtering, measuring, calculating, analyzing, diagnosing, displaying, recording, and storing biomedical data, algorithms and signals in the fields of cardiology, neurology, nephrology, cognitive disorders and chronic pain

39.

ALLIANCE FOR ADVANCING BIOELECTRONIC MEDICINE

      
Serial Number 88982752
Status Registered
Filing Date 2019-10-04
Registration Date 2021-11-02
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services

Goods & Services

Providing information in the field of bioelectronic medicine; providing a website featuring information about bioelectronic medicine

40.

ALLIANCE FOR ADVANCING BIOELECTRONIC MEDICINE

      
Serial Number 88642018
Status Registered
Filing Date 2019-10-04
Registration Date 2023-10-24
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ?
  • 09 - Scientific and electric apparatus and instruments
  • 35 - Advertising and business services
  • 41 - Education, entertainment, sporting and cultural services

Goods & Services

Downloadable podcasts in the field of bioelectronic medicine; electronic publications, namely, books, magazines, articles, and reports featuring information about bioelectronic medicine recorded on computer media Promoting public awareness in the field of bioelectronic medicine; promoting public awareness of bioelectronic medicine by means of public advocacy; providing public policy information in the field of bioelectronic medicine; business research in the field of bioelectronic medicine; promoting collaboration within the scientific, research and medical communities to achieve advances in the field of bioelectronic medicine; business collaboration services, namely, providing a computer-based networking web site for business professionals, academics, and medical professionals to collaborate on, advocate for, and build awareness of bioelectronic medicine Providing a website featuring blogs and non-downloadable publications in the nature of articles, e-books, e-magazines, and reports in the field of bioelectronic medicine; educational services, namely, hosting, arranging, and conducting conferences, seminars, roundtable meetings, webinars in the field of bioelectronic medicine; production of podcasts; entertainment services, namely, providing podcasts in the field of bioelectronic medicine

41.

Systems and methods to visually align signals using delay

      
Application Number 16271462
Grant Number 10356001
Status In Force
Filing Date 2019-02-08
First Publication Date 2019-07-16
Grant Date 2019-07-16
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Fakhar, Sina
  • Foxall, Thomas G.
  • Vlajinic, Branislav

Abstract

Systems, methods, and computer program product embodiments are disclosed for processing and displaying multiple signals in near real-time. An embodiment operates by processing, using a first digital signal processor (DSP) of a first signal module, a first packet associated with a first signal. The embodiment also processes, using a second DSP of a second signal module, a second packet associated with a second signal. The embodiment equalizes a first processing delay associated with the first DSP with a second processing delay associated with the second DSP such that the first DSP completes processing of the first packet approximately simultaneously with the second DSP completing processing of the second packet. The embodiment then displays the processed first packet approximately simultaneously with the display of the processed second packet.

IPC Classes  ?

  • H04L 12/863 - Queue scheduling, e.g. Round Robin
  • H04L 12/26 - Monitoring arrangements; Testing arrangements
  • H03H 17/02 - Frequency-selective networks
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

42.

Systems and methods for evaluation of electrophysiology systems

      
Application Number 15103278
Grant Number 10456057
Status In Force
Filing Date 2014-12-12
First Publication Date 2016-11-03
Grant Date 2019-10-29
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir S.
  • Foxall, Thomas George
  • Fakhar, Sina
  • Vlajinic, Branislav

Abstract

A signal processing evaluator and methods that compare a digital waveform of a cardiac signal to a first processed signal generated by a test system such as an EP recorder or an EP mapping system and generates a first finding evaluating how well the test system filters non-cardiac signals or simulated body impedance. A simulator and methods that send cardiac signals including non-cardiac signals or simulated body impedance to a test system and to a signal processing evaluator for evaluation of the test system.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61B 5/0452 - Detecting specific parameters of the electrocardiograph cycle
  • A61B 5/042 - Electrodes specially adapted therefor for introducing into the body
  • A61B 5/0472 - Detecting abnormal QRS complex
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

43.

BIOSIG TECHNOLOGIES

      
Serial Number 87174008
Status Registered
Filing Date 2016-09-16
Registration Date 2017-04-25
Owner BioSig Technologies, Inc. (USA)
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for recording heart activity

44.

SYSTEMS AND METHODS FOR EVALUATION OF ELECTROPHYSIOLOGY SYSTEMS

      
Application Number US2014070165
Publication Number 2015/089480
Status In Force
Filing Date 2014-12-12
Publication Date 2015-06-18
Owner BIOSIG TECHNOLOGIES, INC. (USA)
Inventor
  • Drakulic, Budimir, S.
  • Foxall, Thomas, George
  • Fakhar, Sina
  • Vlajinic, Branislav

Abstract

A signal processing evaluator and methods that compare a digital waveform of a cardiac signal to a first processed signal generated by a test system such as an EP recorder or an EP mapping system and generates a first finding evaluating how well the test system filters non-cardiac signals or simulated body impedance. A simulator and methods that send cardiac signals including non-cardiac signals or simulated body impedance to a test system and to a signal processing evaluator for evaluation of the test system.

IPC Classes  ?

  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • A61B 5/0428 - Input circuits specially adapted therefor
  • A61B 5/0452 - Detecting specific parameters of the electrocardiograph cycle

45.

PURE EP

      
Serial Number 85617649
Status Registered
Filing Date 2012-05-04
Registration Date 2016-01-26
Owner BIOSIG TECHNOLOGIES, INC. (USA)
NICE Classes  ? 10 - Medical apparatus and instruments

Goods & Services

Medical instruments for use in DIAGNOSIS OF ARRHYTHMIA