Abstract

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

IPC Classes  ?

• C07H 19/048 - Pyridine radicals
• C07H 1/06 - SeparationPurification

Goods & Services

Synthetic resins for use in combinatorial, peptide and organic chemistry; Reagents for scientific and research use; Chemical and biochemical preparations, namely, reagents for peptide synthesis; Resins for use in solidphase peptide synthesis for scientific diagnostic use; Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA).

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA).

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for scientific and research use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis research purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities, for medical treatment purpose and diagnostic use; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties for treating blood disorders, autoimmune diseases, and allergic conditions; Organic chemical preparations and enzymes for medical laboratory diagnostic analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory diagnostic analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for scientific and research use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis research purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities, for medical treatment purpose and diagnostic use; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties for treating blood disorders, autoimmune diseases, and allergic conditions; Organic chemical preparations and enzymes for medical laboratory diagnostic analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory diagnostic analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use

Abstract

The present invention relates to methods of making a nicotinamide ribofuranoside salt, in particular a crystalline nicotinamide ribofuranoside salt, via salt metathesis comprising subjecting nicotinamide ribofuranoside hydrogen malate or nicotinamide ribofuranoside hydrogen tartrate to salt metathesis to afford the nicotinamide ribofuranoside salt. In an alternative, acylated nicotinamide ribofuranoside hydrogen malate or acylated nicotinamide ribofuranoside hydrogen tartrate is subjected to salt metathesis followed by deacylation to afford the nicotinamide ribofuranoside salt.

IPC Classes  ?

• C07H 17/02 - Heterocyclic radicals containing only nitrogen as ring hetero atoms

Abstract

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in FIG. 1 and FIG. 2.

IPC Classes  ?

• C07D 209/36 - Oxygen atoms in position 3, e.g. adrenochrome

Abstract

The present invention relates to a method of detecting a microorganism having hippuricase activity comprising contacting a sample to be tested with p-hydroxyhippuric acid or a salt thereof, a detection reagent and an oxidizing reagent. The present invention further relates to a kit comprising p-hydroxyhippuric acid, a detection reagent and an oxidizing reagent, and further relates to the use of the kit for detecting a microorganism having hippuricase activity or for discriminating a microorganism having hippuricase activity from a microorganism without hippuricase activity or to the use of the kit in a method of detecting a microorganism having hippuricase activity.

IPC Classes  ?

• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Goods & Services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations.

Goods & Services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations

Goods & Services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations

Abstract

The present invention relates to a method for assessing cell viability of bacterial and fungal cells and to a method for the detection of bacterial and fungal cells with specific enzyme activities. The methods of the present invention rely on the real-time measurement of the level of luminescence signal from a luciferase enzyme directly from a growing culture of bacterial or fungal cells. Furthermore, the present invention relates to a method for assessing susceptibility of bacterial cells to antibiotics by measuring ATP levels using a luciferase assay system.

IPC Classes  ?

• C12Q 1/20 - Testing for antimicrobial activity of a material using multifield media
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase

Abstract

The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

IPC Classes  ?

• C07H 1/06 - SeparationPurification
• C07H 19/048 - Pyridine radicals

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa).

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa). Packaging and filling articles to the order and specification of others; warehouse services. Custom manufacture of medicines and diagnostics for others; custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields. Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA). Packaging and filling articles to the order and specification of others; warehouse services. Custom manufacture of medicines and diagnostics for others; custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields. Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA) Packaging and filling articles to the order and specification of others; Warehouse services Custom manufacture of medicines and diagnostics for others; Custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics

Goods & Services

Custom manufacture of medicines and diagnostics for others; Custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA) Packaging and filling articles to the order and specification of others; Warehouse services Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology for scientific purposes; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms

Abstract

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

IPC Classes  ?

• C07H 19/048 - Pyridine radicals
• C07H 1/06 - SeparationPurification

Abstract

The present invention relates to methods of making a nicotinamide ribofuranoside salt, in particular a crystalline nicotinamide ribofuranoside salt, via salt metathesis comprising subjecting nicotinamide ribofuranoside hydrogen malate or nicotinamide ribofuranoside hydrogen tartrate to salt metathesis to afford the nicotinamide ribofuranoside salt. In an alternative, acylated nicotinamide ribofuranoside hydrogen malate or acylated nicotinamide ribofuranoside hydrogen tartrate is subjected to salt metathesis followed by deacylation to afford the nicotinamide ribofuranoside salt.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/048 - Pyridine radicals
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom

Abstract

The present invention relates to a method of making nicotinamide ribofuranoside salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

IPC Classes  ?

• C07H 19/048 - Pyridine radicals
• C07H 1/06 - SeparationPurification

Abstract

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in Fig. 1 and Fig. 2.

IPC Classes  ?

• C07D 209/36 - Oxygen atoms in position 3, e.g. adrenochrome

Abstract

The present invention relates to a method for assessing cell viability of bacterial and fungal cells and to a method for the detection of bacterial and fungal cells with specific enzyme activities. The methods of the present invention rely on the real-time measurement of the level of luminescence signal from a luciferase enzyme directly from a growing culture of bacterial or fungal cells. Furthermore, the present invention relates to a method for assessing susceptibility of bacterial cells to antibiotics by measuring ATP levels using a luciferase assay system.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/18 - Testing for antimicrobial activity of a material
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
• G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

IPC Classes  ?

• C07H 1/06 - SeparationPurification
• C07H 19/048 - Pyridine radicals

Abstract

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/048 - Pyridine radicals

Abstract

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

IPC Classes  ?

• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/048 - Pyridine radicals

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as a culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (MRSA); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (MRSA); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Abstract

The present invention relates to dioxetane compounds, their use in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods.

IPC Classes  ?

• C07D 321/00 - Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups

Abstract

The present invention relates to dioxetane compounds of Formula la or lb, a compound of Formula II and their applications.

IPC Classes  ?

• C07D 321/00 - Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups
• C07F 5/04 - Esters of boric acids

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as a culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; ; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Abstract

The present invention generally relates to a class of antimicrobial compounds, to compositions containing said compounds and to the use of said compounds for medical and non-medical purposes. More specifically, the present invention relates to antimicrobial compounds capable of changing microbiota composition and function by selectively inhibiting distinct microbial species.

IPC Classes  ?

• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• C07D 213/89 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
• C07H 17/02 - Heterocyclic radicals containing only nitrogen as ring hetero atoms
• C07D 213/69 - Two or more oxygen atoms
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof

Goods & Services

Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli

Goods & Services

Chemical preparations for laboratory analysis. Preparations for medical and veterinarian purposes, namely, chemical reagents  for medical or veterinarian purposes;   preparations of microorganisms for medical and veterinary use;   biological preparations for medical purposes;   chemical preparations for medical purposes;   diagnostic preparations for medical purposes; enzymes for medical purposes;   enzyme preparations for medical purposes.

Goods & Services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics.

Goods & Services

Preparations for medical and veterinarian purposes, namely, chemical reagents for medical or veterinarian purposes; preparations of microorganisms for medical and veterinary use; biological preparations for medical purposes; chemical preparations for medical purposes and laboratory analysis; diagnostic preparations for medical purposes; enzymes for medical purposes; enzyme preparations for medical purposes.

Goods & Services

Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme

Abstract

A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.

IPC Classes  ?

• C07D 221/18 - Ring systems of four or more rings
• C09B 67/08 - Coated particulate pigments or dyes
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 67/44 - Solutions
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/10 - Enterobacteria
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase

Abstract

A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.

IPC Classes  ?

• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/06 - Quantitative determination
• C12Q 1/10 - Enterobacteria

Abstract

A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/06 - Quantitative determination
• C12Q 1/10 - Enterobacteria

Abstract

A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2- a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.

IPC Classes  ?

• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 67/00 - Influencing the physical, e.g. the dyeing or printing, properties of dyestuffs without chemical reaction, e.g. by treating with solventsProcess features in the making of dyestuff preparationsDyestuff preparations of a special physical nature, e.g. tablets, films
• C12Q 1/10 - Enterobacteria

Abstract

A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.

IPC Classes  ?

• C07D 209/70 - [b]- or [c]-condensed containing carbocyclic rings other than six-membered
• C07D 209/36 - Oxygen atoms in position 3, e.g. adrenochrome
• C07D 487/04 - Ortho-condensed systems

Goods & Services

Indicators in the nature of pure chemical substances made in the form of synthetic compounds that react to the presence of enzymes, acids, bases, reducing agents, oxidizing agents or electromagnetic irradiation by turning colors or emitting light

Abstract

A novel indicator platform comprises a plurality of 1 H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.

IPC Classes  ?

• C07D 209/36 - Oxygen atoms in position 3, e.g. adrenochrome
• C07D 487/04 - Ortho-condensed systems
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
• C07H 7/06 - Heterocyclic radicals

Abstract

A method of detecting the presence of selected living cells in a sample, comprises the steps of contacting the sample with a substrate compound and monitoring for a signal caused by a metabolic activity of said selected living cells resulting in a release of a signalogenic moiety from the substrate compound. The substrate compound has the formula (I), wherein X is O or NH, A is H or a first enzymatically hydrolyzable group, B is R3 or CH2—Y—D, wherein Y is O or NH and D is H or a second enzymatically hydrolyzable group, R1, R2 and R3 are independently selected inert groups, and Sig—O is a signalogenic moiety that upon release thereof converts to said signalophore.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/10 - Enterobacteria

Abstract

A method of detecting Shigella apyrase enzyme comprises the steps of : a) contacting a sample suspected of containing said Shigella apyrase enzyme withan endo-pyrophosphatase substrate comprising an endo pyrophosphate group that is susceptible to cleavage by said enzyme, said cleavage yielding a signalogenspecies comprising a monophosphate group, said signalogen species being susceptible to phosphatase-induced formation of a signalophore species; b) providing a phosphatase activity so as to convert said signalogen species into a signalophore species; c) monitoring for a signal from said signalophore species as an indication of the presence of said Shigella apyrase enzyme. The essay can be used for the detection of Shigella spp. or enteroinvasive E. CoIi.

IPC Classes  ?

• C12Q 1/42 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving phosphatase
• C12Q 1/10 - Enterobacteria

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics.

Goods & Services

Culture medium for selective growth and diagnostic identification of scientific bacteria.

Goods & Services

culture medium for selective growth and diagnostic identification of scientific bacteria

Goods & Services

biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics