Abrégé

The present invention relates to a method of making nicotinamide ribofuranoside salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

Classes IPC  ?

• C07H 19/048 - Radicaux pyridine
• C07H 1/06 - SéparationPurification

Abrégé

The present invention relates to a method of detecting a microorganism having hippuricase activity comprising contacting a sample to be tested with p-hydroxyhippuric acid or a salt thereof, a detection reagent and an oxidizing reagent. The present invention further relates to a kit comprising p-hydroxyhippuric acid, a detection reagent and an oxidizing reagent, and further relates to the use of the kit for detecting a microorganism having hippuricase activity or for discriminating a microorganism having hippuricase activity from a microorganism without hippuricase activity or to the use of the kit in a method of detecting a microorganism having hippuricase activity.

Classes IPC  ?

• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique

Abrégé

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

Classes IPC  ?

• C07H 19/048 - Radicaux pyridine
• C07H 1/06 - SéparationPurification

Produits et services

Synthetic resins for use in combinatorial, peptide and organic chemistry; Reagents for scientific and research use; Chemical and biochemical preparations, namely, reagents for peptide synthesis; Resins for use in solidphase peptide synthesis for scientific diagnostic use; Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA).

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA).

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for scientific and research use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis research purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities, for medical treatment purpose and diagnostic use; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties for treating blood disorders, autoimmune diseases, and allergic conditions; Organic chemical preparations and enzymes for medical laboratory diagnostic analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory diagnostic analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for scientific and research use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis research purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities, for medical treatment purpose and diagnostic use; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties for treating blood disorders, autoimmune diseases, and allergic conditions; Organic chemical preparations and enzymes for medical laboratory diagnostic analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory diagnostic analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use

Abrégé

The present invention relates to methods of making a nicotinamide ribofuranoside salt, in particular a crystalline nicotinamide ribofuranoside salt, via salt metathesis comprising subjecting nicotinamide ribofuranoside hydrogen malate or nicotinamide ribofuranoside hydrogen tartrate to salt metathesis to afford the nicotinamide ribofuranoside salt. In an alternative, acylated nicotinamide ribofuranoside hydrogen malate or acylated nicotinamide ribofuranoside hydrogen tartrate is subjected to salt metathesis followed by deacylation to afford the nicotinamide ribofuranoside salt.

Classes IPC  ?

• C07H 17/02 - Radicaux hétérocycliques contenant uniquement des atomes d'azote comme hétéro-atomes du cycle

Abrégé

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in FIG. 1 and FIG. 2.

Classes IPC  ?

• C07D 209/36 - Atomes d'oxygène en position 3, p. ex. adrénochrome

Abrégé

The present invention relates to a method of detecting a microorganism having hippuricase activity comprising contacting a sample to be tested with p-hydroxyhippuric acid or a salt thereof, a detection reagent and an oxidizing reagent. The present invention further relates to a kit comprising p-hydroxyhippuric acid, a detection reagent and an oxidizing reagent, and further relates to the use of the kit for detecting a microorganism having hippuricase activity or for discriminating a microorganism having hippuricase activity from a microorganism without hippuricase activity or to the use of the kit in a method of detecting a microorganism having hippuricase activity.

Classes IPC  ?

• C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Produits et services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations.

Produits et services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations

Produits et services

Providing incentive award programs through issuance and processing of loyalty points for purchase of a company's goods and services; Arranging and conducting incentive reward programs to promote the sale of chemicals and medicinal preparations

Abrégé

The present invention relates to a method for assessing cell viability of bacterial and fungal cells and to a method for the detection of bacterial and fungal cells with specific enzyme activities. The methods of the present invention rely on the real-time measurement of the level of luminescence signal from a luciferase enzyme directly from a growing culture of bacterial or fungal cells. Furthermore, the present invention relates to a method for assessing susceptibility of bacterial cells to antibiotics by measuring ATP levels using a luciferase assay system.

Classes IPC  ?

• C12Q 1/20 - Test de l'activité antimicrobienne d'un matériau utilisant des milieux polyvalents
• C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
• C12Q 1/66 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une luciférase

Abrégé

The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

Classes IPC  ?

• C07H 1/06 - SéparationPurification
• C07H 19/048 - Radicaux pyridine

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa).

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa). Packaging and filling articles to the order and specification of others; warehouse services. Custom manufacture of medicines and diagnostics for others; custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields. Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA). Packaging and filling articles to the order and specification of others; warehouse services. Custom manufacture of medicines and diagnostics for others; custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields. Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA) Packaging and filling articles to the order and specification of others; Warehouse services Custom manufacture of medicines and diagnostics for others; Custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics

Produits et services

Custom manufacture of medicines and diagnostics for others; Custom manufacturing for others in the pharmaceutical, diagnostic, veterinary, biotechnology and chemistry fields Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA) Packaging and filling articles to the order and specification of others; Warehouse services Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of medicines and diagnostics

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology for scientific purposes; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms

Abrégé

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

Classes IPC  ?

• C07H 19/048 - Radicaux pyridine
• C07H 1/06 - SéparationPurification

Abrégé

The present invention relates to methods of making a nicotinamide ribofuranoside salt, in particular a crystalline nicotinamide ribofuranoside salt, via salt metathesis comprising subjecting nicotinamide ribofuranoside hydrogen malate or nicotinamide ribofuranoside hydrogen tartrate to salt metathesis to afford the nicotinamide ribofuranoside salt. In an alternative, acylated nicotinamide ribofuranoside hydrogen malate or acylated nicotinamide ribofuranoside hydrogen tartrate is subjected to salt metathesis followed by deacylation to afford the nicotinamide ribofuranoside salt.

Classes IPC  ?

• C07H 1/00 - Procédés de préparation des dérivés du sucre
• C07H 19/048 - Radicaux pyridine
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle

Abrégé

The present invention relates to a method of making nicotinamide ribofuranoside salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

Classes IPC  ?

• C07H 19/048 - Radicaux pyridine
• C07H 1/06 - SéparationPurification

Abrégé

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in Fig. 1 and Fig. 2.

Classes IPC  ?

• C07D 209/36 - Atomes d'oxygène en position 3, p. ex. adrénochrome

Abrégé

The present invention relates to a method for assessing cell viability of bacterial and fungal cells and to a method for the detection of bacterial and fungal cells with specific enzyme activities. The methods of the present invention rely on the real-time measurement of the level of luminescence signal from a luciferase enzyme directly from a growing culture of bacterial or fungal cells. Furthermore, the present invention relates to a method for assessing susceptibility of bacterial cells to antibiotics by measuring ATP levels using a luciferase assay system.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• C12Q 1/66 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une luciférase
• G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence

Abrégé

The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

Classes IPC  ?

• C07H 1/06 - SéparationPurification
• C07H 19/048 - Radicaux pyridine

Abrégé

The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as such, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

Classes IPC  ?

• C07H 1/00 - Procédés de préparation des dérivés du sucre
• C07H 19/048 - Radicaux pyridine

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; chemical reagents for medical research use in the field of immunology. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as a culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); biochemical and organic chemical reagents for clinical diagnostic laboratory use; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (MRSA); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:H7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (MRSA); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; chemical reagents for medical or veterinarian use; chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain escherichia coli o157:h7; chemical preparations for medical purposes, namely, for cholesterol testing to prevent possible consequences of hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of listeria, clostridium, bacillus and staphylococcus; chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of escherichia coli; medical preparations for the diagnosis of staphylococus aureus, in particular for methicillin-resistant staphylococcus aureus (mrsa); chemical reagents for medical research use in the field of immunology; chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms.

Abrégé

The present invention relates to dioxetane compounds, their use in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods.

Classes IPC  ?

• C07D 321/00 - Composés hétérocycliques contenant des cycles comportant deux atomes d'oxygène comme uniques hétéro-atomes du cycle, non prévus par les groupes

Abrégé

The present invention relates to dioxetane compounds of Formula la or lb, a compound of Formula II and their applications.

Classes IPC  ?

• C07D 321/00 - Composés hétérocycliques contenant des cycles comportant deux atomes d'oxygène comme uniques hétéro-atomes du cycle, non prévus par les groupes
• C07F 5/04 - Esters des acides boriques

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics. Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as a culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, namely, aminoglutethimides, carbamazepines, griseofulvins, and primidones, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemical reagents for clinical diagnostic laboratory use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics; ; Chemical reagents for medical research use in the field of immunology; Chemical reagents for medical laboratory analysis purposes, namely, for use as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms Medicinal preparations, namely, photosensitizing agents used as a dermatologic drug for the treatment of skin cancer by phototherapy; Chemical reagents for medical or veterinarian use; Chemical reagents for use as culture media for cultures of microorganisms for medical use, namely, for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Organic chemical preparations for medical purposes, namely, immunomodulators with anti-inflammatory properties; Organic chemical preparations and enzymes for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA)

Abrégé

The present invention generally relates to a class of antimicrobial compounds, to compositions containing said compounds and to the use of said compounds for medical and non-medical purposes. More specifically, the present invention relates to antimicrobial compounds capable of changing microbiota composition and function by selectively inhibiting distinct microbial species.

Classes IPC  ?

• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
• A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
• C07D 213/89 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles avec des hétéro-atomes liés directement à l'atome d'azote du cycle
• C07H 17/02 - Radicaux hétérocycliques contenant uniquement des atomes d'azote comme hétéro-atomes du cycle
• C07D 213/69 - Au moins deux atomes d'oxygène
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges

Produits et services

Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli

Produits et services

Chemical preparations for laboratory analysis. Preparations for medical and veterinarian purposes, namely, chemical reagents  for medical or veterinarian purposes;   preparations of microorganisms for medical and veterinary use;   biological preparations for medical purposes;   chemical preparations for medical purposes;   diagnostic preparations for medical purposes; enzymes for medical purposes;   enzyme preparations for medical purposes.

Produits et services

Biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics.

Produits et services

Preparations for medical and veterinarian purposes, namely, chemical reagents for medical or veterinarian purposes; preparations of microorganisms for medical and veterinary use; biological preparations for medical purposes; chemical preparations for medical purposes and laboratory analysis; diagnostic preparations for medical purposes; enzymes for medical purposes; enzyme preparations for medical purposes.

Produits et services

Medicinal preparations for photosensitizing agents used as a dermatologic drug or prodrug for the treatment of skin cancer by phototherapy; Chemical reagents for medical and veterinarian use; Chemical reagents for cultures of microorganisms for medical use, namely, in culture media for the isolation and identification of the bacteria strain Escherichia coli O157:H7; Chemical preparations for medical purposes, namely, for Cholesterol testing to prevent possible consequences of Hypercholesterolemia such as atherosclerosis, coronary heart disease and other forms of cardiovascular diseases; Chemical preparations for medical purposes, namely, for novel enzyme responsive inhibitors that allow for modifications of the composition of microbial communities; Chemical preparations for medical purposes, namely, for immunology research; Organic chemical preparations for medical purposes, namely, immunomodulatory compounds with anti-inflammatory properties; Organic chemical preparations for medical laboratory analysis purposes, namely, for medical detection, identification and quantification of strains of pathogenic bacteria; Chemical preparations for medical laboratory analysis purposes, namely, for medical immunological and microbiological blood testing; Chemical preparations for medical laboratory analysis purposes, namely, used as a routine medical supplement to blood culture media in vitro to inhibit blood coagulation and to improve the detection limits for individual microorganisms; Chemical preparations for medical laboratory analysis purposes, namely, for medical detection of pathogenic bacteria, namely, various strains of Listeria, Clostridium, Bacillus and Staphylococcus; Chemical preparations for medical laboratory analysis purposes, namely, for the medical detection and quantification of bacteria strains of Escherichia coli; Medical preparations for the diagnosis of Staphylococus aureus, in particular for Methicillin-resistant Staphylococcus aureus (MRSA); Medical enzyme

Abrégé

A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.

Classes IPC  ?

• C07D 221/18 - Systèmes cycliques d'au moins quatre cycles
• C09B 67/08 - Colorants ou pigments particulaires enrobés
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09B 67/44 - Solutions
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/10 - Entérobactéries
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase

Abrégé

A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.

Classes IPC  ?

• C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/06 - Détermination quantitative
• C12Q 1/10 - Entérobactéries

Abrégé

A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/06 - Détermination quantitative
• C12Q 1/10 - Entérobactéries

Abrégé

A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2- a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.

Classes IPC  ?

• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09B 67/00 - Traitements, sans réaction chimique, influençant les propriétés physiques, p. ex. de teintures ou d'impression, des matières colorantes, p. ex. traitement par des solvantsCaractéristiques du procédé de fabrication des préparations tinctorialesPréparations tinctoriales ayant un aspect physique particulier, p. ex. tablettes, feuilles
• C12Q 1/10 - Entérobactéries

Abrégé

A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.

Classes IPC  ?

• C07D 209/70 - Systèmes cycliques contenant au moins trois cycles condensés en [b] ou en [c] contenant des carbocycles autres que des cycles à six chaînons
• C07D 209/36 - Atomes d'oxygène en position 3, p. ex. adrénochrome
• C07D 487/04 - Systèmes condensés en ortho

Produits et services

Indicators in the nature of pure chemical substances made in the form of synthetic compounds that react to the presence of enzymes, acids, bases, reducing agents, oxidizing agents or electromagnetic irradiation by turning colors or emitting light

Abrégé

A novel indicator platform comprises a plurality of 1 H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.

Classes IPC  ?

• C07D 209/36 - Atomes d'oxygène en position 3, p. ex. adrénochrome
• C07D 487/04 - Systèmes condensés en ortho
• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
• C07H 7/06 - Radicaux hétérocycliques

Abrégé

A method of detecting the presence of selected living cells in a sample, comprises the steps of contacting the sample with a substrate compound and monitoring for a signal caused by a metabolic activity of said selected living cells resulting in a release of a signalogenic moiety from the substrate compound. The substrate compound has the formula (I), wherein X is O or NH, A is H or a first enzymatically hydrolyzable group, B is R3 or CH2—Y—D, wherein Y is O or NH and D is H or a second enzymatically hydrolyzable group, R1, R2 and R3 are independently selected inert groups, and Sig—O is a signalogenic moiety that upon release thereof converts to said signalophore.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/10 - Entérobactéries

Produits et services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry; biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics.

Produits et services

Culture medium for selective growth and diagnostic identification of scientific bacteria.

Produits et services

culture medium for selective growth and diagnostic identification of scientific bacteria

Produits et services

biochemicals and organic chemicals used as enzyme substrates, enzyme inducers, enzyme inactivators, or cultural medium additives for use in the field of microbiology and molecular biology; biochemical and organic chemicals for clinical diagnostic use; biochemical and organic chemicals for use in the manufacture of pharmaceuticals and cosmetics