Abstract

In general, this invention discloses methods for extracting and analyzing coatings from implanted and excised animal tissue medical devices; wherein the coating comprises at least one biodegradable polymer and at least one or more therapeutic ingredients. The present invention describes optimal conditions for extraction and isolation of biodegradable polymers and therapeutics in medical devices or complex pharmaceutical agent formulations prior and after implanting or injecting into animal tissues. Particularly this work relates to accurate isolation and quantification of ppm amounts of polymer and/or therapeutics without biological interferences. The use of GPC/SEC systems equipped with light scattering detectors enables "absolute" or "true" molecular weight determination. All of these improvements allow for accurate determination of the degradation profile of the polymer/therapeutic component independent of polymer standards used in conventional GPC/SEC.

IPC Classes  ?

• G01N 1/34 - PurifyingCleaning
• B01D 11/02 - Solvent extraction of solids
• G01N 33/15 - Medicinal preparations
• G01N 30/86 - Signal analysis

Abstract

The present invention discloses methods for packing chromatography columns using dual- purpose valve assemblies. The key components of the dual-purpose valve comprise of the following; the inlet port (224) which sits on the first adaptor (212), the hollow nozzle (320) which passes through the first adaptor (212) cavity and is closed on the bottom end, and the internal movable plug (322). Different components of our device work in way that the mobile phase and analyte(s) distribution is not blocked in the centre of the column, allowing for a uniform and homogeneous fluid distribution. This simple yet novel design offers uniform fluid distribution, stable packed bed, eliminates any void volume, and prevents bacterial contamination/growth. Ease of use, scalability, ease of cleaning, cost-efficiency and fine-tuning packing conditions such as pressure are key features of this invention.

IPC Classes  ?

• B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus

Abstract

The invention relates to a UV -initiated RAFT -type polymerization for producing hydrophobically associative terpolymers in an aqueous solution. The terpolymers produced by this method can be used as aqueous rheological modifiers. Specifically, the invention relates to a hydrophobically associating terpolymers and a method to produce same using a light initiated iniferter. The monomers used in the present invention are selected from: a monomer having a water-soluble monoethylenically unsaturated group; a monomer having an ionic water-soluble monoethylenically unsaturated group; and a monomer having a monoethylenically unsaturated monomer capable of forming hydrophobically associative bonds in aqueous medium. The iniferter is initiated with light of wavelength between 250-400 nm. The resultant terpolymer is produced in a cost-effective, simple, and one-step process and can be used to thicken aqueous mediums with less or equal amounts of polymer than currently available.

IPC Classes  ?

• C08F 220/02 - Monocarboxylic acids having less than ten carbon atomsDerivatives thereof
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• B01D 21/01 - Separation of suspended solid particles from liquids by sedimentation using flocculating agents
• C02F 1/56 - Macromolecular compounds
• C08F 2/10 - Aqueous solvent
• C08F 2/48 - Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
• C08J 3/075 - Macromolecular gels
• C09K 8/588 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of specific polymers
• C09K 8/68 - Compositions based on water or polar solvents containing organic compounds
• C09K 8/80 - Compositions for reinforcing fractures, e.g. compositions of proppants used to keep the fractures open
• D21H 21/20 - Wet strength agents