Abrégé

In general, this invention discloses methods for extracting and analyzing coatings from implanted and excised animal tissue medical devices; wherein the coating comprises at least one biodegradable polymer and at least one or more therapeutic ingredients. The present invention describes optimal conditions for extraction and isolation of biodegradable polymers and therapeutics in medical devices or complex pharmaceutical agent formulations prior and after implanting or injecting into animal tissues. Particularly this work relates to accurate isolation and quantification of ppm amounts of polymer and/or therapeutics without biological interferences. The use of GPC/SEC systems equipped with light scattering detectors enables "absolute" or "true" molecular weight determination. All of these improvements allow for accurate determination of the degradation profile of the polymer/therapeutic component independent of polymer standards used in conventional GPC/SEC.

Classes IPC  ?

• G01N 1/34 - PurificationNettoyage
• B01D 11/02 - Extraction par solvants de solides
• G01N 33/15 - Préparations médicinales
• G01N 30/86 - Analyse des signaux

Abrégé

The present invention discloses methods for packing chromatography columns using dual- purpose valve assemblies. The key components of the dual-purpose valve comprise of the following; the inlet port (224) which sits on the first adaptor (212), the hollow nozzle (320) which passes through the first adaptor (212) cavity and is closed on the bottom end, and the internal movable plug (322). Different components of our device work in way that the mobile phase and analyte(s) distribution is not blocked in the centre of the column, allowing for a uniform and homogeneous fluid distribution. This simple yet novel design offers uniform fluid distribution, stable packed bed, eliminates any void volume, and prevents bacterial contamination/growth. Ease of use, scalability, ease of cleaning, cost-efficiency and fine-tuning packing conditions such as pressure are key features of this invention.

Classes IPC  ?

• B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil

Abrégé

The invention relates to a UV -initiated RAFT -type polymerization for producing hydrophobically associative terpolymers in an aqueous solution. The terpolymers produced by this method can be used as aqueous rheological modifiers. Specifically, the invention relates to a hydrophobically associating terpolymers and a method to produce same using a light initiated iniferter. The monomers used in the present invention are selected from: a monomer having a water-soluble monoethylenically unsaturated group; a monomer having an ionic water-soluble monoethylenically unsaturated group; and a monomer having a monoethylenically unsaturated monomer capable of forming hydrophobically associative bonds in aqueous medium. The iniferter is initiated with light of wavelength between 250-400 nm. The resultant terpolymer is produced in a cost-effective, simple, and one-step process and can be used to thicken aqueous mediums with less or equal amounts of polymer than currently available.

Classes IPC  ?

• C08F 220/02 - Acides monocarboxyliques contenant moins de dix atomes de carboneLeurs dérivés
• A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
• A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
• B01D 21/01 - Séparation par sédimentation de particules solides en suspension dans des liquides en utilisant des agents de floculation
• C02F 1/56 - Composés macromoléculaires
• C08F 2/10 - Solvant aqueux
• C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible
• C08J 3/075 - Gels macromoléculaires
• C09K 8/588 - Compositions pour les méthodes de récupération assistée pour l'extraction d'hydrocarbures, c.-à-d. pour améliorer la mobilité de l'huile, p. ex. fluides de déplacement caractérisées par l'utilisation de polymères spécifiques
• C09K 8/68 - Compositions à base d'eau ou de solvants polaires contenant des composés organiques
• C09K 8/80 - Compositions pour renforcer les fractures, p. ex. compositions pour agents de soutènement utilisés pour maintenir les fractures ouvertes
• D21H 21/20 - Agents de résistance à l'état humide