SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Wang, Yanzi
Zhang, Bingxing
Wang, Wen
Zhang, Yunfei
Abstract
A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed, wherein R is a phenyl substituted with an electron withdrawing group or a phenyl substituted with an electron donating group. The pleuromutilin derivative containing a thiazolo[5,4-C]pyridine side chain in the present invention exhibits good in vitro antibacterial activity and improves the problem of poor solubility of pleuromutilin derivatives.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07C 303/28 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
2.
Pleuromutilin onium salt derivative containing a 3H-imidazo[4,5-c]pyridine side chain, and a preparation method and application thereof
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Wang, Yanzi
Kang, Kairui
Zhang, Bingxing
Wang, Wen
Zhang, Yunfei
Wang, Mengzhou
Abstract
mycoplasma, in vivo and in vitro antibacterial activity, and are of great value in the development of anti-resistant bacteria drugs and have good medical application prospects.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Ke, Changhua
Xing, Yue
Zhou, Jingjing
Hu, Jinrong
Zhang, Boxin
Zhang, Yunfei
Zhang, Bingxing
Wang, Wen
Li, Fei
Li, Yifan
Abstract
The present invention provides a method for constructing a fingerprint of a Xin Su Ning capsule and a fingerprint. The method includes: S1: taking contents of Xin Su Ning capsules of different batches, adding a methanol aqueous solution, and performing ultrasonic extraction to obtain test article solutions; S2: injecting the test article solutions into a high performance liquid chromatograph, performing gradient elution, performing chromatographic analysis, and recording chromatograms from 0 to 140 min; S3: importing the chromatograms into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system to obtain a fingerprint; and S4: performing mass spectral analysis on the test article solutions, and determining chemical constituents of chromatographic peaks in the fingerprint according to results of the mass spectral analysis. The method for constructing a fingerprint of a Xin Su Ning capsule provided in the present invention has advantages of simple, stable and high precision and good reproducibility.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Hu, Liangbin
Mo, Haizhen
Zhou, Xiaohui
Li, Hongbo
Xu, Dan
Liu, Zhenbin
Wang, Zhen
Abstract
The present invention relates to the technical field of biomedicine. Disclosed is a use of ferrous ions in the preparation of burn infection treatment drugs and burn care products. The ferrous compound formulation comprises a ferrous compound, a protective agent, a dressing matrix, and a solvent; the ferrous compound includes but is not limited to ferrous sulfate; and the dressing matrix includes but is not limited to sodium alginate and hyaluronic acid. During preparation, the ferrous compound, the protective agent, the dressing matrix and the solvent are mixed and heated to obtain a ferrous compound hydrogel. The ferrous compound hydrogel can solve the problem of burn infection caused by pseudomonas aeruginosa while avoiding antibiotic resistance, and can promote wound healing.
Shaanxi University of Science and Technology (China)
Inventor
Chen, Haifeng
Hu, Yanlong
Dong, Shaobo
Wang, Bo
Niu, Yao
Yang, Yueying
Abstract
A sugar cane shred press roller and a presser including the same are provided, which belong to the technical field of sugar-making equipment. Several circumferential bosses are arranged in an axial direction of a cylindrical roller body of the sugar cane shred press roller; modified cylindrical helical gears with opposite modification coefficients are formed on both sides of each of the circumferential bosses; and an annular juice discharge groove is formed between adjacent circumferential bosses. A presser with the sugar cane shred press roller is provided, axes of several sugar cane shred press rollers are spatially parallel with each other, the circumferential bosses and the juice discharge grooves of the adjacent sugar cane shred press rollers fit with each other and have gaps left, and the modified cylindrical helical gears of the adjacent sugar cane shred press rollers are meshed with each other.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Ke, Changhua
Wang, Yanzi
Liu, Yuting
Yang, Xiuding
Zhou, Ying
Li, Jiaxuan
Abstract
A fingerprint spectrum construction method for Xihuang capsules and a fingerprint spectrum includes: S1: taking contents of a Xihuang capsule, adding a methanol-chloroform-phosphoric acid solution, and carrying out ultrasonic extraction to obtain a Xihuang capsule test solution; S2: dissolving cholic acid, hyodeoxycholic acid, deoxycholic acid, bilirubin, muscone, and myrrhone in ethanol to obtain a mixed standard solution 1; dissolving quassin, 11-carbonyl-β-boswellic acid, 11-carbonyl-β-acetyl-boswellic acid, acetyl-11α-methoxy-β-boswellic acid, and sandaracopimaric acid in methanol to obtain a mixed standard solution 2; S3: respectively carrying out chromatography on the Xihuang capsule test solution and the mixed standard solutions 1 and 2, and recording corresponding chromatograms; and S4: constructing a fingerprint spectrum of the Xihuang capsule according to the chromatogram of the Xihuang capsule test solution and the chromatograms of the mixed standard solutions 1 and 2. The method can accurately, clearly and objectively evaluate the quality of Xihuang capsules.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Hu, Jinrong
Zhang, Boxin
Ke, Changhua
Yang, Shan
Zhou, Jingjing
Li, Jiaxuan
Xie, Qiufang
Ge, Yue
Wang, Wenxue
Abstract
A fingerprint spectrum construction method for a new compound aloe capsule and a fingerprint spectrum includes: (1) taking powder of a new compound aloe capsule, carrying out reflux extraction, adding methanol, carrying out ultrasonic treatment, filtering, and taking a subsequent filtrate as a test solution; dissolving barbaloin, aloe-emodin, indirubin, tryptanthrin, aloesin, and β-sitosterol in methanol to obtain reference solutions; (2) injecting the test solution and the reference solutions into a high performance liquid chromatograph for gradient elution to obtain a chromatogram of the new compound aloe capsule and chromatograms of the reference solutions, respectively; and (3) labeling chemical components of peaks on the chromatogram of the new compound aloe capsule according to the chromatogram of the new compound aloe capsule and the chromatograms of the reference solutions to obtain a fingerprint spectrum of the new compound aloe capsule.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Zhang, Boxin
Ke, Changhua
Yang, Shan
Zhou, Jingjing
Hu, Jinrong
Liu, Yuting
Abstract
The present invention provides a Ganoderma lucidum β-glucan extract, a preparation method and detection method therefor. The preparation method includes: S1: crushing fruiting bodies of Ganoderma lucidum, mixing the crushed fruiting bodies with a solvent, adding trypsin for enzymatic hydrolysis for 0.5-2 h, and separating to obtain a Ganoderma lucidum fruiting body filter residue; S2: mixing the Ganoderma lucidum fruiting body filter residue with an alkali solution, carrying out ultrasonic extraction with heating, adjusting the pH value of the obtained filtrate to be neutral, and concentrating to obtain a crude Ganoderma lucidum polysaccharide; S3: carrying out alcohol precipitation on the crude Ganoderma lucidum polysaccharide, separating the obtained precipitate, and freeze-drying to obtain a crude Ganoderma lucidum β-glucan extract; and S4: purifying the crude Ganoderma lucidum β-glucan extract by glucose gel column chromatography to obtain a Ganoderma lucidum β-glucan extract.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wan, Jia
Liang, Chenguan
Tian, Lei
Zhang, Jie
Xin, Liang
Li, Jingyi
Zhao, Yuqing
Abstract
The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Kong, Yang
Wang, Changzhao
Tian, Bin
Lin, Fang
Li, Zihao
Abstract
A method for preparing dihydromyricetin nanocrystals includes: uniformly dispersing dihydromyricetin in a good solvent to obtain a dihydromyricetin solution; uniformly dispersing a precipitator and a stabilizer in water to obtain a mixed solution, and then adding the dihydromyricetin solution into the mixed solution and mixing uniformly under a stirring condition to obtain a dihydromyricetin nanocrystal solution; and drying the dihydromyricetin nanocrystal solution to obtain the dihydromyricetin nanocrystals. The method for preparing the dihydromyricetin nanocrystals by an anti-solvent method is simple and easy to implement, low in cost, good in nanocrystal stability, small in organic solvent consumption, and safe and environment-friendly in preparation process.
C07D 311/30 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
12.
Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Yang, Xiuding
Xin, Liang
Xia, Juan
Zhao, Yuqing
Zhang, Jie
Tian, Lei
Li, Jingyi
Zhang, Shaojun
Zhao, Qianqian
Abstract
A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)
5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Fan, Xiaopu
Song, Ning
Abstract
The invention discloses high-precision mobile robot management and scheduling system, and relates to the technical field of industrial robots, comprising industrial robot, AGV, secondary positioning device and upper computer, wherein the secondary positioning devices are arranged on corresponding workstations of processing machine tool, when the processing machine tool performs processing tasks, the upper computer selects the AGV arranged with industrial robot and navigates the same to the secondary positioning device, and after the secondary positioning device and the chassis of the industrial robot are locked, the industrial robot can assist the processing machine tool in parts machining. The system in the invention perfectly combines the mobile robot and fixed robot, thereby achieving not only flexibility of mobile robot, but also the high precision of the fixed robot.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Qi, Yong
Chen, Hongyan
Yan, Linshan
Zhang, Ningzhan
Abstract
A skin audible watch for orientation identification includes a dial (1) and a strap (2). A plurality of sound collection modules (3) are arranged along a circumference of the dial (1), and the sound collection modules (3) are sequentially connected with a digital filter (4), an analog-to-digital converter (5), a single-chip microcomputer (6), and a row and column drive module (7); the single-chip microcomputer (6) is also connected with vibration motors (8) and a gyroscope (9); a number of the vibration motors corresponds to a number of orientations; the digital filter (4), analog-to-digital converter, single-chip microcomputer, row and column drive module, the vibration motors and the gyroscope are located inside the dial; the row and column drive module is connected with a current contact pin (12), and a free end of the current contact pin extends out of a surface of the vibration motors.
G04G 21/00 - Input or output devices integrated in time-pieces
A61F 11/04 - Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense, e.g. through the touch sense
G04G 21/06 - Input or output devices integrated in time-pieces using voice
H04R 1/32 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only
G09B 21/00 - Teaching, or communicating with, the blind, deaf or mute
15.
SOLDER JOINT LIFE TESTING APPARATUS AND SOLDER JOINT LIFE PREDICTION METHOD
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Xie, Zhaoyang
Zhu, Zhaofei
Wang, Fengwei
Cheng, Yihui
Wang, Binkai
Wang, Xiaolin
Abstract
A solder joint life testing apparatus and a solder joint life prediction method. The solder joint life testing apparatus comprises: a frame (30), a supporting structure (10) and a driving structure (40), wherein the supporting structure (10) is configured to support a device to be tested (20), wherein a first surface of said device (20) is fixed to the surface of the supporting structure (10), and the second surface of said device (20) opposite to the first surface is connected to the frame (30). Said device (20) comprises a first device layer (21), a second device layer (22) and a solder joint layer (23). The solder joint layer (23) is located between the first device layer (21) and the second device layer (22), and is configured to fix the first device layer (21) and the second device layer (22). The driving structure (40) is located on the side of the supporting structure (10) away from the said device (20) and is connected to the frame (30), the driving structure (40) is connected to the supporting structure (10), and the driving structure (40) is configured to provide a tensile force acting on the supporting structure (10), wherein the value of the tensile force periodically varies within a preset value range.
G01N 3/38 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means
16.
Pleuromutilin (E)-4-(1-imidazoylmethyl)cinnamic acid ester with anti-drug resistant bacteria activity and a method of preparing the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Yang, Wenjing
Zhao, Qianqian
Xin, Liang
Li, Jingyi
Yang, Dan
Bian, Ruina
Zhang, Jie
Zhao, Yuqing
Li, Han
Tian, Bin
Wang, Yongbo
Qi, Liang
Mao, Gennian
Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I):
is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
C07D 233/60 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhao, Qianqian
Zhang, Jie
Xin, Liang
Li, Jingyi
Bian, Ruina
Zhao, Yuqing
Yang, Dan
Li, Han
Tian, Bin
Wang, Yongbo
Liang, Chengyuan
Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I):
is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
18.
Pleuromutilin 2-[(diphenylmethyl)thio] acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhao, Qianqian
Zhao, Yuqing
Yang, Dan
Li, Jingyi
Xin, Liang
Bian, Ruina
Zhang, Jie
Li, Han
Tian, Bin
Wang, Yongbo
Liang, Chengyuan
Qi, Liang
Mao, Gennian
Abstract
A compound with anti-drug resistant bacteria activity having the formula (I):
(I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhao, Qianqian
Xin, Liang
Li, Jingyi
Bian, Ruina
Yang, Dan
Qi, Liang
Tian, Bin
Zha, Jian
Yao, Wenbo
Mao, Gennian
Li, Han
Shi, Chunyang
Wang, Yongbo
Xu, Jingwen
Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I):
(I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
C07C 69/88 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
C07C 67/14 - Preparation of carboxylic acid esters from carboxylic acid halides
20.
Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wang, Yongbo
Li, Han
Mao, Gennian
Tian, Bin
Yang, Dan
Liang, Chengyuan
Yang, Xiuding
Yao, Wenbo
Qiao, Guaiping
Hui, Nan
Li, Juan
Xin, Liang
Li, Jingyi
Bian, Ruina
Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I):
is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Qiang, Xihuai
Wang, Xuyang
Xie, Chao
Abstract
A cationic cyanuric chloride derivative tanning agent and a preparation method thereof are disclosed. The method includes: mixing 9.22-36.88 parts of cyanuric chloride, 21.35-100.31 parts of a solvent, and 7.12-33.44 parts of deionized water, all by mass, in an ice-water bath to obtain a mixture A; at a temperature of 0-5° C., adding 2.98-20.44 parts of a tertiary ammonia compound to the mixture A, and subjecting the resulting mixture to a reaction for 4-6 hours, during which its pH value is adjusted with an acid-binding agent solution to 6.0-7.0, to obtain a mixture B; filtering the mixture B, washing the filter cake, and vacuum drying for 4-6 h to obtain a solid C, and grinding to obtain the cationic cyanuric chloride derivative tanning agent.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Xu, Na
Xing, Yanmei
Wang, Xuechuan
Abstract
A method of preparing a vinyl collagen microsphere polyamide fiber composite material includes the following steps: step 1: modifying a collagen with methacrylic anhydride to obtain a vinyl collagen, then emulsifying and cross-linking the vinyl collagen to obtain vinyl collagen microspheres; step 2: treating a polyamide fiber substrate with formaldehyde to obtain a hydroxylated polyamide fiber substrate, treating the hydroxylated polyamide fiber with (3-mercaptopropyl)trimethoxysilane (MPS) to obtain a sulfhydrylated polyamide fiber substrate; and step 3: modifying the sulfhydrylated polyamide fiber substrate with the vinyl collagen microspheres to obtain the vinyl collagen microsphere polyamide fiber composite material.
C08L 77/00 - Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chainCompositions of derivatives of such polymers
C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements
D06M 13/127 - Mono-aldehydes, e.g. formaldehydeMonoketones
D06M 13/507 - Organic silicon compounds without carbon-silicon bond
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Du, Cong
Zhao, Qianqian
Xin, Liang
Li, Jingyi
Yang, Dan
Hui, Nan
Qiao, Guaiping
Li, Han
Li, Yanjun
Qi, Liang
Yao, Wenbo
Mao, Gennian
Abstract
A compound with anti-drug resistant bacteria activity having the following formula (I):
is disclosed. A method of preparing the compound of formula (I) is also disclosed.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
25.
PLANAR VACUUM FIELD EMISSION TRIODE APPARATUS HAVING NANOSCALE CHANNEL
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wang, Xiao
Abstract
Provided is a planar vacuum field emission triode apparatus having a nanoscale channel. The apparatus comprises a conductive film (5) and a device electrode (4), and the conductive film (5) is disposed on the device electrode (4). The apparatus is characterized in that one or more heat transfer layers (6) are provided above or below the conductive film (5), and a preparation material of the heat transfer layers (6) is a material having good insulation performance and good thermal conductivity. The invention solves the problem of accumulated Joule heat on a conductive film of a vacuum field emission triode in the prior art, and enables heat inside the vacuum field emission triode having a nanoscale channel to be conducted quickly, so as to prevent the dimension and structure of the nanoscale channel from being damaged due to the accumulated Joule heat, thereby improving the stability of VFET devices and extending the service life thereof.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Li, Xi
Zhu, Zhaofei
Ling, Li
Chang, Bo
Cai, Dong
Abstract
A micro-device transfer apparatus, comprising: a support plate (3) that has a circular through hole, and a tension disk (4); a super-hydrophobic elastic film (9) is arranged at the bottom part of the circular through hole; the tension disk (4) moves up and down within the circular through hole; a first hydrophilic region is provided on the surface of the super-hydrophobic elastic film (9), the shape of the first hydrophilic region being consistent with the shape of the upper surface of a micro-device to be picked up; then the tension disk (4) is moved to come into contact with the super-hydrophobic elastic film to homogeneously expand the first hydrophilic region into a second hydrophilic region; the shape of the second hydrophilic region is consistent with the shape of the upper surface of the micro-device, and the areas thereof are close; the second hydrophilic region picks up the micro-device by means of a first liquid bridge; the tension disk (4) disengages from contact with the the super-hydrophobic elastic film (9), such that the second hydrophilic region contracts homogeneously, the first liquid bridge is broken, and the picked-up micro-device is released. A micro-device transfer method and a computer-readable storage medium are further comprised.
H01L 21/68 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for positioning, orientation or alignment
H01L 21/677 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for conveying, e.g. between different work stations
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zha, Jian
Liu, Zhiqiang
Gong, Guoli
Sun, Runcong
Abstract
A method for extracting protein without lysing cells includes: step 1: combining a penetrating peptide CPP gene having a sequence as set forth in SEQ ID NO: 1 and a bacterial lyase T4L gene having a sequence as set forth in SEQ ID NO: 2 through a flexible connecting peptide GGGGS gene having a sequence as set forth in SEQ ID NO: 3 to form a fusion enzyme CPP-T4L gene having a sequence as set forth in SEQ ID NO: 4; step 2: inserting the fusion enzyme CPP-T4L gene, and obtaining a recombinant host strain; step 3: cloning a target protein expression gene, and then constructing a recombinant expression strain; step 4: first inducing the expression of the target protein expression gene; starting the expression of the fusion enzyme CPP-T4L gene, and releasing a target protein; step 5: collecting cell lysis supernatant to recover the target protein.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wang, Xuechuan
Zheng, Manhui
Liu, Xinhua
Yue, Ouyang
Hou, Mengdi
Wang, Youyou
Abstract
A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at −4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Tian, Bin
Li, Juan
Hui, Nan
Qiao, Guaiping
Xin, Liang
Li, Jingyi
Yang, Dan
Li, Han
Li, Yanjun
Qi, Liang
Yao, Wenbo
Liang, Chengyuan
Abstract
A compound with anti-drug resistant bacteria activity having the following formula
(I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.
C07C 69/736 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
C07C 67/56 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
30.
POSS modified polyacrylate fluoride-free waterproof agent and preparation method thereof
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhou, Jianhua
Wang, Lin
Li, Yan
Chen, Xiaoyu
Abstract
A POSS modified polyacrylate fluorine-free waterproofing agent includes following components: 1-10 wt % of a functionalized POSS monomer, 2-20 wt % of methyl methacrylate, 3-26 wt % of butyl acrylate, 1-10 wt % of a long-chain acrylate monomer, 0.5-3.5 wt % of an initiator, 0.5-4 wt % of a reactive cationic emulsifier, and 50-80 wt % of deionized water. A method of preparing a POSS modified polyacrylate fluorine-free waterproofing agent is also disclosed.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Yang, Dan
Li, Jingyi
Xin, Liang
Zhao, Qianqian
Qi, Liang
Tian, Bin
Zha, Jian
Yao, Wenbo
Mao, Gennian
Li, Han
Shi, Chunyang
Wang, Yongbo
Xu, Jingwen
Abstract
A compound with anti-drug resistant bacteria activity having the following formula
(I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
C07C 233/83 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
32.
Method for increasing bulkiness of reconstituted tobacco
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhang, Meiyun
Song, Shunxi
Jiang, Xue
Yang, Bin
Nie, Jingyi
Tan, Jiaojun
Abstract
A method for increasing bulkiness of reconstituted tobacco by adding tobacco stem particles includes (1) pulverizing a first portion of tobacco stems to obtain tobacco stem particles; (2) classifying the tobacco stem particles with mesh sieves and selecting the tobacco stem particles with a predetermined mesh size; (3) extracting a second portion of the tobacco stems with water and grinding to form a tobacco stem slurry that has a beating degree of 12-14° SR, and mixing the tobacco stem slurry with tobacco leaves in a weight ratio of 6:4 and grinding to obtaining a tobacco slurry that has a beating degree of 18-20° SR; (4) cutting plant fiber pulp boards and dispersing in water to form a plant fiber pulp; (5) preparing a filler solution that contains 10 wt % of a mineral filler; (6) mixing, rolling and drying to obtain the reconstituted tobacco.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Zhang, Meiyun
Tan, Jiaojun
Yang, Bin
Song, Shunxi
Nie, Jingyi
Jiang, Xue
Abstract
A method of preparing an aramid paper coated with aramid nanofibers includes the following steps: (1) mixing a meta-aramid fibrid slurry and a chopped meta-aramid fiber slurry, filtering, pressing and drying to obtain a meta-aramid paper; (2) mixing potassium hydroxide, deionized water, dimethyl sulfoxide, and para-aramid nanofibers in a container, and stirring to obtain a para-aramid nanofiber coating solution; and (3) applying the para-aramid nanofiber coating solution to a first side of the meta-aramid paper, washing with deionized water, and drying; applying the para-aramid nanofiber coating solution to a second side of the meta-aramid paper, washing with deionized water, and drying; and hot pressing to obtain the aramid paper coated with aramid nanofibers.
C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
C07C 67/52 - SeparationPurificationStabilisationUse of additives by change in the physical state, e.g. crystallisation
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
35.
Salmonella detection ability and a method of preparing the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Lu, Qi
Xin, Liang
Qiao, Guaiping
Li, Jingyi
Wu, Kangxiong
Li, Han
Tian, Bin
Abstract
3 solution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrosol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrosol gelatin solution, and heating the hydroxytyrosol gelatin solution at 40-70° C.; (4) ultrasonicating the hydroxytyrosol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Li, Han
Hui, Nan
Tian, Bin
Ju, Xingke
Liu, Yuzhi
Yang, Dan
Xu, Jingwen
Qi, Liang
Zhao, Qianqian
Wang, Yongbo
Abstract
A compound having the formula (I):
is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
C07C 69/94 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
39.
6-aminouracil cassic acid ester with antibacterial activity and a method of preparing the same
C07D 239/545 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
40.
Hydroxytyrosol 4-methoxycinnamic acid ester with antibacterial activity and a method of preparing the same
C07C 69/736 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Fan, Xiaopu
Song, Ning
Abstract
Disclosed is a high-precision movable robot secondary positioning device (300), comprising an industrial robot base (120), positioners (330, 340, 350), and clamping mechanisms (310, 320), wherein the positioners (330, 340, 350) achieve complete positioning on an industrial robot (100) according to a six-point positioning principle, and the clamping mechanisms (310, 320) enable the base (120) to be tightly clamped towards the positioning faces of the positioners (330, 340, 350). The industrial robot base (120) is provided with a crankshaft (121) corresponding to each of the clamping mechanisms (310, 320), and a driving device on the base (120) drives each crankshaft (121) to rotate, such that the clamping mechanisms (310, 320) can be driven to tightly clamp, firmly lock or rapidly release the base (120). Based on the device (300), by means of interaction with the industrial robot (100) provided with the base (120), positioning, clamping and firm locking of the robot (100) are achieved when the robot (100) is working, such that the rigidity and precision of the industrial robot (100) are improved; and the robot (100) is released when the robot (100) is idle, the robot (100) can be carried on an automated guided vehicle (AGV) (200) to move to a new station, and the working range of the robot (100) is thus widened.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Fan, Xiaopu
Song, Ning
Abstract
A high-precision mobile robot management and dispatch system, relating to the technical field of industrial robots, and comprising an industrial robot (100), an AGV (200), a secondary positioning apparatus (300), and an upper computer (400). The secondary positioning apparatus (300) is mounted at a station corresponding to a machining lathe (500). When the machining lathe (500) executes a machining task, the upper computer (400) selects and navigates the AGV (200) mounted with the industrial robot (100) to the second positioning apparatus (300), and after the secondary positioning apparatus (300) is locked to a base (120) of the industrial robot (100), the industrial robot (100) can assist the machining lathe (500) in part machining. The high-precision mobile robot management and dispatch system perfectly combine a mobile robot with a stationary robot, and has both the flexibility of a mobile robot and the high precision of a stationary robot.
C07C 67/56 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
C07C 69/52 - Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
C07C 67/00 - Preparation of carboxylic acid esters
C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
44.
2 material, method of preparing the same, and application thereof
Device for high pressure spray and counter-current precipitation extraction of herbal medicine and a method for extracting herbal medicine using the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Hui, Nan
Li, Juan
Qiao, Guaiping
Tang, Yonghong
Mao, Gennian
Li, Han
Tian, Bin
Zhao, Qianqian
Wang, Yongbo
Yang, Dan
Liu, Hanyang
Abstract
A device for high pressure spray and counter-current precipitation extraction of herbal medicine is disclosed. A method for extracting herbal medicine using the device is also disclosed.
C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
47.
Method for preparing high fluffiness down by multiple treatments with metal salts
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Qiang, Taotao
Pu, Yadong
Zhang, Qi
Abstract
A method for preparing a high fluffiness down by multiple treatments with metal salts includes: degreasing a down sample with a degreasing agent; washing the down sample with water; oxidizing the down sample with an oxidizing agent; washing the down sample with water; conducting a first crosslinking treatment with basic zirconium sulfate; washing the down sample with water; conducting a second crosslinking treatment with basic aluminum sulfate; washing the down sample with water; and drying the down sample to obtain the high fluffiness down.
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C07C 29/10 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
49.
Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Liang, Chengyuan
Ju, Xingke
Ding, Shunjun
Tian, Lei
Liu, Yuzhi
Xie, Xiaolin
Zhang, Dezhu
Yao, Wenbo
Yang, Dan
Abstract
A gossypol isatin Schiff base compound with antitumor activities represented by formula I:
2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Xu, Qinfeng
Dong, Jing
Song, Hongxin
Liu, Jianlan
Abstract
Disclosed are a real-time fluorescent quantitative PCR detection method based on a ruthenium complex and a kit. The present invention establishes a real-time fluorescent quantitative PCR detection method with a ruthenium complex as a fluorescent dye. The results show that the ruthenium complex, as a fluorescent dye, can be used within a wider concentration range, and a melting curve can be generated for specific amplification verification and multiple PCR detection.
Method for preparing collagen aggregate and collagen from chromium-containing tanned leather wastes by combined acid-enzyme controlled degradation technology
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wang, Xuechuan
Hou, Mengdi
Liu, Xinhua
Liang, Chengyuan
Yue, Ouyang
Zheng, Manhui
Zhu, Xing
Han, Qingxin
Li, Ji
Zhang, Huijie
Qiang, Taotao
Abstract
A method for preparing a collagen from a chromium-containing tanned leather waste is disclosed. The method includes acid dechromation, obtaining a collagen aggregate, and converting the collagen aggregate to the collagen. The method also includes a reaction in a supercritical carbon dioxide reactor.
H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
Inventor
Wang, Xuechuan
Yue, Ouyang
Liu, Xinhua
Qiang, Taotao
Ren, Longfang
Tian, Lei
Jia, Minyi
Ju, Xingke
Liang, Chengyuan
Abstract
Enterococcus faecalis detection ability includes: 1) mixing a sturgeon skin gelatin and distilled water in a ratio of 1:15-1:25 (w/v) at 50-70° C. and filtering to obtain a sturgeon skin gelatin solution; 2) adding aesculin and a glycerin solution to the sturgeon skin gelatin solution, stirring the resulted sturgeon skin gelatin solution at 30-50° C. for 30 minutes, and filtering; and 3) removing air bubbles from the sturgeon skin gelatin solution of step 2) under reduced pressure, placing the sturgeon skin gelatin solution on an acrylic glass, and drying the sturgeon skin gelatin solution at in a vented oven 25° C. and 45-55% relative humidity for 24 hours to obtain the aesculin sturgeon skin gelatin film.
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
CHINA LEATHER AND FOOTWEAR INDUSTRY RESEARCH INSTITUTE (China)
Inventor
Zhang, James
Ma, Xingyuan
Zhang, Xiaolei
Niu, Jianmin
Liu, Donghui
Xu, Xuhui
Abstract
A method for improving sanitary performance of figured sea-island superfine fiber synthetic leather is provided. The method is characterized in that it includes the following steps: a) treating a superfine fiber synthetic leather base cloth with a collagen, so as to make the collagen cross link and fix on the superfine fibers in said superfine synthetic leather base cloth; b) making a hydrophilic material infiltrate and adsorb into said superfine fiber synthetic leather base cloth treated with the collagen; c) surface constructing treating said superfine fiber synthetic leather base cloth infiltrated with the hydrophilic material. The hydrophility of the treated superfine fiber surface is equivalent to that of a collagenous fiber of natural leather, so that the permeability to water vapor and the water-absorbing capacity of the synthetic leather are improved. Finally, a coating with micropores is formed on the synthetic leather surface after surface constructing treating, thus integrally improving the permeability to water vapor and the air permeability of the synthetic leather.
D06N 7/04 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material characterised by their surface properties
D06M 15/263 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated carboxylic acidsSalts or esters thereof