Abstract

A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed, wherein R is a phenyl substituted with an electron withdrawing group or a phenyl substituted with an electron donating group. The pleuromutilin derivative containing a thiazolo[5,4-C]pyridine side chain in the present invention exhibits good in vitro antibacterial activity and improves the problem of poor solubility of pleuromutilin derivatives.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 31/04 - Antibacterial agents
• C07C 303/28 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof

Abstract

mycoplasma, in vivo and in vitro antibacterial activity, and are of great value in the development of anti-resistant bacteria drugs and have good medical application prospects.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides a method for constructing a fingerprint of a Xin Su Ning capsule and a fingerprint. The method includes: S1: taking contents of Xin Su Ning capsules of different batches, adding a methanol aqueous solution, and performing ultrasonic extraction to obtain test article solutions; S2: injecting the test article solutions into a high performance liquid chromatograph, performing gradient elution, performing chromatographic analysis, and recording chromatograms from 0 to 140 min; S3: importing the chromatograms into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system to obtain a fingerprint; and S4: performing mass spectral analysis on the test article solutions, and determining chemical constituents of chromatographic peaks in the fingerprint according to results of the mass spectral analysis. The method for constructing a fingerprint of a Xin Su Ning capsule provided in the present invention has advantages of simple, stable and high precision and good reproducibility.

IPC Classes  ?

• G01N 30/86 - Signal analysis
• G01N 30/02 - Column chromatography
• G01N 30/16 - Injection
• G01N 30/72 - Mass spectrometers

Abstract

Lactobacillus helveticus KD-3 of the present disclosure is used to prepare lyophilized bacterial powder.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/20 - MilkWheyColostrum
• A61P 39/04 - Chelating agents

Abstract

The present invention relates to the technical field of biomedicine. Disclosed is a use of ferrous ions in the preparation of burn infection treatment drugs and burn care products. The ferrous compound formulation comprises a ferrous compound, a protective agent, a dressing matrix, and a solvent; the ferrous compound includes but is not limited to ferrous sulfate; and the dressing matrix includes but is not limited to sodium alginate and hyaluronic acid. During preparation, the ferrous compound, the protective agent, the dressing matrix and the solvent are mixed and heated to obtain a ferrous compound hydrogel. The ferrous compound hydrogel can solve the problem of burn infection caused by pseudomonas aeruginosa while avoiding antibiotic resistance, and can promote wound healing.

IPC Classes  ?

• A61K 33/26 - IronCompounds thereof
• A61K 9/06 - OintmentsBases therefor
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 31/04 - Antibacterial agents

Abstract

A sugar cane shred press roller and a presser including the same are provided, which belong to the technical field of sugar-making equipment. Several circumferential bosses are arranged in an axial direction of a cylindrical roller body of the sugar cane shred press roller; modified cylindrical helical gears with opposite modification coefficients are formed on both sides of each of the circumferential bosses; and an annular juice discharge groove is formed between adjacent circumferential bosses. A presser with the sugar cane shred press roller is provided, axes of several sugar cane shred press rollers are spatially parallel with each other, the circumferential bosses and the juice discharge grooves of the adjacent sugar cane shred press rollers fit with each other and have gaps left, and the modified cylindrical helical gears of the adjacent sugar cane shred press rollers are meshed with each other.

IPC Classes  ?

• C13B 10/06 - Sugar-cane crushers
• C13B 5/04 - Shredding sugar cane

Abstract

A fingerprint spectrum construction method for Xihuang capsules and a fingerprint spectrum includes: S1: taking contents of a Xihuang capsule, adding a methanol-chloroform-phosphoric acid solution, and carrying out ultrasonic extraction to obtain a Xihuang capsule test solution; S2: dissolving cholic acid, hyodeoxycholic acid, deoxycholic acid, bilirubin, muscone, and myrrhone in ethanol to obtain a mixed standard solution 1; dissolving quassin, 11-carbonyl-β-boswellic acid, 11-carbonyl-β-acetyl-boswellic acid, acetyl-11α-methoxy-β-boswellic acid, and sandaracopimaric acid in methanol to obtain a mixed standard solution 2; S3: respectively carrying out chromatography on the Xihuang capsule test solution and the mixed standard solutions 1 and 2, and recording corresponding chromatograms; and S4: constructing a fingerprint spectrum of the Xihuang capsule according to the chromatogram of the Xihuang capsule test solution and the chromatograms of the mixed standard solutions 1 and 2. The method can accurately, clearly and objectively evaluate the quality of Xihuang capsules.

IPC Classes  ?

• G01N 30/86 - Signal analysis
• G01N 1/28 - Preparing specimens for investigation
• G01N 30/02 - Column chromatography
• G01N 30/06 - Preparation
• G01N 30/74 - Optical detectors

Abstract

A fingerprint spectrum construction method for a new compound aloe capsule and a fingerprint spectrum includes: (1) taking powder of a new compound aloe capsule, carrying out reflux extraction, adding methanol, carrying out ultrasonic treatment, filtering, and taking a subsequent filtrate as a test solution; dissolving barbaloin, aloe-emodin, indirubin, tryptanthrin, aloesin, and β-sitosterol in methanol to obtain reference solutions; (2) injecting the test solution and the reference solutions into a high performance liquid chromatograph for gradient elution to obtain a chromatogram of the new compound aloe capsule and chromatograms of the reference solutions, respectively; and (3) labeling chemical components of peaks on the chromatogram of the new compound aloe capsule according to the chromatogram of the new compound aloe capsule and the chromatograms of the reference solutions to obtain a fingerprint spectrum of the new compound aloe capsule.

IPC Classes  ?

• G01N 30/86 - Signal analysis
• G01N 30/14 - Preparation by elimination of some components
• G01N 30/72 - Mass spectrometers

Abstract

The present invention provides a Ganoderma lucidum β-glucan extract, a preparation method and detection method therefor. The preparation method includes: S1: crushing fruiting bodies of Ganoderma lucidum, mixing the crushed fruiting bodies with a solvent, adding trypsin for enzymatic hydrolysis for 0.5-2 h, and separating to obtain a Ganoderma lucidum fruiting body filter residue; S2: mixing the Ganoderma lucidum fruiting body filter residue with an alkali solution, carrying out ultrasonic extraction with heating, adjusting the pH value of the obtained filtrate to be neutral, and concentrating to obtain a crude Ganoderma lucidum polysaccharide; S3: carrying out alcohol precipitation on the crude Ganoderma lucidum polysaccharide, separating the obtained precipitate, and freeze-drying to obtain a crude Ganoderma lucidum β-glucan extract; and S4: purifying the crude Ganoderma lucidum β-glucan extract by glucose gel column chromatography to obtain a Ganoderma lucidum β-glucan extract.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.

IPC Classes  ?

• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• A61P 31/04 - Antibacterial agents
• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

A method for preparing dihydromyricetin nanocrystals includes: uniformly dispersing dihydromyricetin in a good solvent to obtain a dihydromyricetin solution; uniformly dispersing a precipitator and a stabilizer in water to obtain a mixed solution, and then adding the dihydromyricetin solution into the mixed solution and mixing uniformly under a stirring condition to obtain a dihydromyricetin nanocrystal solution; and drying the dihydromyricetin nanocrystal solution to obtain the dihydromyricetin nanocrystals. The method for preparing the dihydromyricetin nanocrystals by an anti-solvent method is simple and easy to implement, low in cost, good in nanocrystal stability, small in organic solvent consumption, and safe and environment-friendly in preparation process.

IPC Classes  ?

• C07D 311/30 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Abstract

A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) 5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

IPC Classes  ?

• A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
• A61P 31/04 - Antibacterial agents

Abstract

The invention discloses high-precision mobile robot management and scheduling system, and relates to the technical field of industrial robots, comprising industrial robot, AGV, secondary positioning device and upper computer, wherein the secondary positioning devices are arranged on corresponding workstations of processing machine tool, when the processing machine tool performs processing tasks, the upper computer selects the AGV arranged with industrial robot and navigates the same to the secondary positioning device, and after the secondary positioning device and the chassis of the industrial robot are locked, the industrial robot can assist the processing machine tool in parts machining. The system in the invention perfectly combines the mobile robot and fixed robot, thereby achieving not only flexibility of mobile robot, but also the high precision of the fixed robot.

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

A skin audible watch for orientation identification includes a dial (1) and a strap (2). A plurality of sound collection modules (3) are arranged along a circumference of the dial (1), and the sound collection modules (3) are sequentially connected with a digital filter (4), an analog-to-digital converter (5), a single-chip microcomputer (6), and a row and column drive module (7); the single-chip microcomputer (6) is also connected with vibration motors (8) and a gyroscope (9); a number of the vibration motors corresponds to a number of orientations; the digital filter (4), analog-to-digital converter, single-chip microcomputer, row and column drive module, the vibration motors and the gyroscope are located inside the dial; the row and column drive module is connected with a current contact pin (12), and a free end of the current contact pin extends out of a surface of the vibration motors.

IPC Classes  ?

• H04R 1/20 - Arrangements for obtaining desired frequency or directional characteristics
• H04R 3/00 - Circuits for transducers
• G04G 21/00 - Input or output devices integrated in time-pieces
• A61F 11/04 - Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense, e.g. through the touch sense
• G04G 21/06 - Input or output devices integrated in time-pieces using voice
• H04R 1/32 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only
• G09B 21/00 - Teaching, or communicating with, the blind, deaf or mute

Abstract

A solder joint life testing apparatus and a solder joint life prediction method. The solder joint life testing apparatus comprises: a frame (30), a supporting structure (10) and a driving structure (40), wherein the supporting structure (10) is configured to support a device to be tested (20), wherein a first surface of said device (20) is fixed to the surface of the supporting structure (10), and the second surface of said device (20) opposite to the first surface is connected to the frame (30). Said device (20) comprises a first device layer (21), a second device layer (22) and a solder joint layer (23). The solder joint layer (23) is located between the first device layer (21) and the second device layer (22), and is configured to fix the first device layer (21) and the second device layer (22). The driving structure (40) is located on the side of the supporting structure (10) away from the said device (20) and is connected to the frame (30), the driving structure (40) is connected to the supporting structure (10), and the driving structure (40) is configured to provide a tensile force acting on the supporting structure (10), wherein the value of the tensile force periodically varies within a preset value range.

IPC Classes  ?

• G01N 3/38 - Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07D 233/60 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
• A61K 31/4164 - 1,3-Diazoles
• A61P 31/04 - Antibacterial agents

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Abstract

A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07C 323/52 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
• A61P 31/04 - Antibacterial agents
• C07C 319/28 - SeparationPurification

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07C 69/88 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
• C07C 67/14 - Preparation of carboxylic acid esters from carboxylic acid halides

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07D 215/233 - Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
• A61P 31/04 - Antibacterial agents

Abstract

A cationic cyanuric chloride derivative tanning agent and a preparation method thereof are disclosed. The method includes: mixing 9.22-36.88 parts of cyanuric chloride, 21.35-100.31 parts of a solvent, and 7.12-33.44 parts of deionized water, all by mass, in an ice-water bath to obtain a mixture A; at a temperature of 0-5° C., adding 2.98-20.44 parts of a tertiary ammonia compound to the mixture A, and subjecting the resulting mixture to a reaction for 4-6 hours, during which its pH value is adjusted with an acid-binding agent solution to 6.0-7.0, to obtain a mixture B; filtering the mixture B, washing the filter cake, and vacuum drying for 4-6 h to obtain a solid C, and grinding to obtain the cationic cyanuric chloride derivative tanning agent.

IPC Classes  ?

• C07D 251/44 - One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
• C14C 3/26 - Chemical tanning by organic agents using other organic substances, containing halogen

Abstract

A method of preparing a vinyl collagen microsphere polyamide fiber composite material includes the following steps: step 1: modifying a collagen with methacrylic anhydride to obtain a vinyl collagen, then emulsifying and cross-linking the vinyl collagen to obtain vinyl collagen microspheres; step 2: treating a polyamide fiber substrate with formaldehyde to obtain a hydroxylated polyamide fiber substrate, treating the hydroxylated polyamide fiber with (3-mercaptopropyl)trimethoxysilane (MPS) to obtain a sulfhydrylated polyamide fiber substrate; and step 3: modifying the sulfhydrylated polyamide fiber substrate with the vinyl collagen microspheres to obtain the vinyl collagen microsphere polyamide fiber composite material.

IPC Classes  ?

• C08L 77/00 - Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chainCompositions of derivatives of such polymers
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
• D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements
• D06M 13/127 - Mono-aldehydes, e.g. formaldehydeMonoketones
• D06M 13/507 - Organic silicon compounds without carbon-silicon bond
• D06M 15/15 - Proteins or derivatives thereof
• D06M 101/34 - Polyamides

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07D 339/04 - Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
• A61P 31/04 - Antibacterial agents

Abstract

Syringa microphylla seed extract is also disclosed.

IPC Classes  ?

• A61K 36/63 - Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
• A61P 31/04 - Antibacterial agents
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin

Abstract

Provided is a planar vacuum field emission triode apparatus having a nanoscale channel. The apparatus comprises a conductive film (5) and a device electrode (4), and the conductive film (5) is disposed on the device electrode (4). The apparatus is characterized in that one or more heat transfer layers (6) are provided above or below the conductive film (5), and a preparation material of the heat transfer layers (6) is a material having good insulation performance and good thermal conductivity. The invention solves the problem of accumulated Joule heat on a conductive film of a vacuum field emission triode in the prior art, and enables heat inside the vacuum field emission triode having a nanoscale channel to be conducted quickly, so as to prevent the dimension and structure of the nanoscale channel from being damaged due to the accumulated Joule heat, thereby improving the stability of VFET devices and extending the service life thereof.

IPC Classes  ?

• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01J 19/74 - Cooling arrangements
• H01J 21/02 - Tubes with a single discharge path

Abstract

A micro-device transfer apparatus, comprising: a support plate (3) that has a circular through hole, and a tension disk (4); a super-hydrophobic elastic film (9) is arranged at the bottom part of the circular through hole; the tension disk (4) moves up and down within the circular through hole; a first hydrophilic region is provided on the surface of the super-hydrophobic elastic film (9), the shape of the first hydrophilic region being consistent with the shape of the upper surface of a micro-device to be picked up; then the tension disk (4) is moved to come into contact with the super-hydrophobic elastic film to homogeneously expand the first hydrophilic region into a second hydrophilic region; the shape of the second hydrophilic region is consistent with the shape of the upper surface of the micro-device, and the areas thereof are close; the second hydrophilic region picks up the micro-device by means of a first liquid bridge; the tension disk (4) disengages from contact with the the super-hydrophobic elastic film (9), such that the second hydrophilic region contracts homogeneously, the first liquid bridge is broken, and the picked-up micro-device is released. A micro-device transfer method and a computer-readable storage medium are further comprised.

IPC Classes  ?

• H01L 21/68 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for positioning, orientation or alignment
• H01L 21/677 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for conveying, e.g. between different work stations

Abstract

A method for extracting protein without lysing cells includes: step 1: combining a penetrating peptide CPP gene having a sequence as set forth in SEQ ID NO: 1 and a bacterial lyase T4L gene having a sequence as set forth in SEQ ID NO: 2 through a flexible connecting peptide GGGGS gene having a sequence as set forth in SEQ ID NO: 3 to form a fusion enzyme CPP-T4L gene having a sequence as set forth in SEQ ID NO: 4; step 2: inserting the fusion enzyme CPP-T4L gene, and obtaining a recombinant host strain; step 3: cloning a target protein expression gene, and then constructing a recombinant expression strain; step 4: first inducing the expression of the target protein expression gene; starting the expression of the fusion enzyme CPP-T4L gene, and releasing a target protein; step 5: collecting cell lysis supernatant to recover the target protein.

IPC Classes  ?

• C12N 9/96 - Stabilising an enzyme by forming an adduct or a compositionForming enzyme conjugates
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at −4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.

IPC Classes  ?

• A61L 27/60 - Materials for use in artificial skin
• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/08 - Carbon
• B29B 7/90 - Fillers or reinforcements
• B29C 45/00 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor
• B29K 507/04 - Carbon
• B29L 31/00 - Other particular articles
• B29K 105/16 - Fillers

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07C 69/736 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 67/56 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Abstract

A POSS modified polyacrylate fluorine-free waterproofing agent includes following components: 1-10 wt % of a functionalized POSS monomer, 2-20 wt % of methyl methacrylate, 3-26 wt % of butyl acrylate, 1-10 wt % of a long-chain acrylate monomer, 0.5-3.5 wt % of an initiator, 0.5-4 wt % of a reactive cationic emulsifier, and 50-80 wt % of deionized water. A method of preparing a POSS modified polyacrylate fluorine-free waterproofing agent is also disclosed.

IPC Classes  ?

• C08F 20/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08F 2/28 - Emulsion polymerisation with the aid of emulsifying agents cationic
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• C08G 77/04 - Polysiloxanes
• C08K 5/29 - Compounds containing carbon-to-nitrogen double bonds

Abstract

A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

IPC Classes  ?

• C07C 231/24 - SeparationPurification
• C07C 233/83 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Abstract

A method for increasing bulkiness of reconstituted tobacco by adding tobacco stem particles includes (1) pulverizing a first portion of tobacco stems to obtain tobacco stem particles; (2) classifying the tobacco stem particles with mesh sieves and selecting the tobacco stem particles with a predetermined mesh size; (3) extracting a second portion of the tobacco stems with water and grinding to form a tobacco stem slurry that has a beating degree of 12-14° SR, and mixing the tobacco stem slurry with tobacco leaves in a weight ratio of 6:4 and grinding to obtaining a tobacco slurry that has a beating degree of 18-20° SR; (4) cutting plant fiber pulp boards and dispersing in water to form a plant fiber pulp; (5) preparing a filler solution that contains 10 wt % of a mineral filler; (6) mixing, rolling and drying to obtain the reconstituted tobacco.

IPC Classes  ?

• A24B 3/14 - Forming reconstituted tobacco products, e.g. wrapper materials, sheets, imitation leaves, rods, cakesForms of such products
• A24B 15/12 - Chemical features of tobacco products or tobacco substitutes of reconstituted tobacco
• A24B 15/24 - Treatment of tobacco products or tobacco substitutes by extractionTobacco extracts
• A24B 3/18 - Other treatment of leaves, e.g. puffing, crimpling, cleaning
• A24B 15/28 - Treatment of tobacco products or tobacco substitutes by chemical substances

Abstract

A method of preparing an aramid paper coated with aramid nanofibers includes the following steps: (1) mixing a meta-aramid fibrid slurry and a chopped meta-aramid fiber slurry, filtering, pressing and drying to obtain a meta-aramid paper; (2) mixing potassium hydroxide, deionized water, dimethyl sulfoxide, and para-aramid nanofibers in a container, and stirring to obtain a para-aramid nanofiber coating solution; and (3) applying the para-aramid nanofiber coating solution to a first side of the meta-aramid paper, washing with deionized water, and drying; applying the para-aramid nanofiber coating solution to a second side of the meta-aramid paper, washing with deionized water, and drying; and hot pressing to obtain the aramid paper coated with aramid nanofibers.

IPC Classes  ?

• D21H 13/26 - PolyamidesPolyimides
• D21H 15/10 - Composite fibres
• D21H 17/67 - Water-insoluble compounds, e.g. fillers or pigments
• D21H 21/08 - Dispersing agents for fibres
• D06M 101/36 - Aromatic polyamides

Abstract

A compound having the formula (I): (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
• C07C 67/52 - SeparationPurificationStabilisationUse of additives by change in the physical state, e.g. crystallisation
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Abstract

3 solution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrosol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrosol gelatin solution, and heating the hydroxytyrosol gelatin solution at 40-70° C.; (4) ultrasonicating the hydroxytyrosol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Abstract

2O nanosheet-like powder with a thickness in a range of 30-60 nm and a single crystal structure grown along a (002) crystal orientation.

IPC Classes  ?

• C01G 31/02 - Oxides
• H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
• C01G 31/00 - Compounds of vanadium
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

A compound having the formula (I): is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.

IPC Classes  ?

• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
• B01J 20/291 - Gel sorbents
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07C 69/94 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07D 239/545 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07C 69/736 - Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
• C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Abstract

Disclosed is a high-precision movable robot secondary positioning device (300), comprising an industrial robot base (120), positioners (330, 340, 350), and clamping mechanisms (310, 320), wherein the positioners (330, 340, 350) achieve complete positioning on an industrial robot (100) according to a six-point positioning principle, and the clamping mechanisms (310, 320) enable the base (120) to be tightly clamped towards the positioning faces of the positioners (330, 340, 350). The industrial robot base (120) is provided with a crankshaft (121) corresponding to each of the clamping mechanisms (310, 320), and a driving device on the base (120) drives each crankshaft (121) to rotate, such that the clamping mechanisms (310, 320) can be driven to tightly clamp, firmly lock or rapidly release the base (120). Based on the device (300), by means of interaction with the industrial robot (100) provided with the base (120), positioning, clamping and firm locking of the robot (100) are achieved when the robot (100) is working, such that the rigidity and precision of the industrial robot (100) are improved; and the robot (100) is released when the robot (100) is idle, the robot (100) can be carried on an automated guided vehicle (AGV) (200) to move to a new station, and the working range of the robot (100) is thus widened.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions

Abstract

A high-precision mobile robot management and dispatch system, relating to the technical field of industrial robots, and comprising an industrial robot (100), an AGV (200), a secondary positioning apparatus (300), and an upper computer (400). The secondary positioning apparatus (300) is mounted at a station corresponding to a machining lathe (500). When the machining lathe (500) executes a machining task, the upper computer (400) selects and navigates the AGV (200) mounted with the industrial robot (100) to the second positioning apparatus (300), and after the secondary positioning apparatus (300) is locked to a base (120) of the industrial robot (100), the industrial robot (100) can assist the machining lathe (500) in part machining. The high-precision mobile robot management and dispatch system perfectly combine a mobile robot with a stationary robot, and has both the flexibility of a mobile robot and the high precision of a stationary robot.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/16 - Programme controls
• B25J 18/00 - Arms

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07C 69/734 - Ethers
• C07C 67/56 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• C07C 69/52 - Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
• C07C 67/00 - Preparation of carboxylic acid esters
• C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond

Abstract

2.

IPC Classes  ?

• C01G 25/02 - Oxides

Abstract

A device for high pressure spray and counter-current precipitation extraction of herbal medicine is disclosed. A method for extracting herbal medicine using the device is also disclosed.

IPC Classes  ?

• A61K 36/16 - Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• B01D 11/02 - Solvent extraction of solids
• B01D 21/26 - Separation of sediment aided by centrifugal force

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07D 407/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides

Abstract

A method for preparing a high fluffiness down by multiple treatments with metal salts includes: degreasing a down sample with a degreasing agent; washing the down sample with water; oxidizing the down sample with an oxidizing agent; washing the down sample with water; conducting a first crosslinking treatment with basic zirconium sulfate; washing the down sample with water; conducting a second crosslinking treatment with basic aluminum sulfate; washing the down sample with water; and drying the down sample to obtain the high fluffiness down.

IPC Classes  ?

• D06M 19/00 - Treatment of feathers

Abstract

A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

IPC Classes  ?

• C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• C07C 29/10 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Abstract

A gossypol isatin Schiff base compound with antitumor activities represented by formula I: 2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61P 35/00 - Antineoplastic agents
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed are a real-time fluorescent quantitative PCR detection method based on a ruthenium complex and a kit. The present invention establishes a real-time fluorescent quantitative PCR detection method with a ruthenium complex as a fluorescent dye. The results show that the ruthenium complex, as a fluorescent dye, can be used within a wider concentration range, and a melting curve can be generated for specific amplification verification and multiple PCR detection.

IPC Classes  ?

• C12Q 1/6851 - Quantitative amplification

Abstract

A method for preparing a collagen from a chromium-containing tanned leather waste is disclosed. The method includes acid dechromation, obtaining a collagen aggregate, and converting the collagen aggregate to the collagen. The method also includes a reaction in a supercritical carbon dioxide reactor.

IPC Classes  ?

• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Abstract

2O nanosheet-like powder with a thickness in a range of 30-60 nm and a single crystal structure grown along a (002) crystal orientation.

IPC Classes  ?

• C01G 31/02 - Oxides
• H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
• C01G 31/00 - Compounds of vanadium
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

Enterococcus faecalis detection ability includes: 1) mixing a sturgeon skin gelatin and distilled water in a ratio of 1:15-1:25 (w/v) at 50-70° C. and filtering to obtain a sturgeon skin gelatin solution; 2) adding aesculin and a glycerin solution to the sturgeon skin gelatin solution, stirring the resulted sturgeon skin gelatin solution at 30-50° C. for 30 minutes, and filtering; and 3) removing air bubbles from the sturgeon skin gelatin solution of step 2) under reduced pressure, placing the sturgeon skin gelatin solution on an acrylic glass, and drying the sturgeon skin gelatin solution at in a vented oven 25° C. and 45-55% relative humidity for 24 hours to obtain the aesculin sturgeon skin gelatin film.

IPC Classes  ?

• C09H 3/00 - Isolation of glue or gelatine from raw materials, e.g. by extracting, by heating
• C08J 5/18 - Manufacture of films or sheets
• B65D 65/46 - Applications of disintegrable, dissolvable or edible materials
• C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A method for improving sanitary performance of figured sea-island superfine fiber synthetic leather is provided. The method is characterized in that it includes the following steps: a) treating a superfine fiber synthetic leather base cloth with a collagen, so as to make the collagen cross link and fix on the superfine fibers in said superfine synthetic leather base cloth; b) making a hydrophilic material infiltrate and adsorb into said superfine fiber synthetic leather base cloth treated with the collagen; c) surface constructing treating said superfine fiber synthetic leather base cloth infiltrated with the hydrophilic material. The hydrophility of the treated superfine fiber surface is equivalent to that of a collagenous fiber of natural leather, so that the permeability to water vapor and the water-absorbing capacity of the synthetic leather are improved. Finally, a coating with micropores is formed on the synthetic leather surface after surface constructing treating, thus integrally improving the permeability to water vapor and the air permeability of the synthetic leather.

IPC Classes  ?

• D06N 7/04 - Flexible sheet materials not otherwise provided for, e.g. textile threads, filaments, yarns or tow, glued on macromolecular material characterised by their surface properties
• D06M 15/15 - Proteins or derivatives thereof
• D06M 15/11 - Starch or derivatives thereof
• D06M 15/53 - Polyethers
• D06M 15/263 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated carboxylic acidsSalts or esters thereof
• D06M 15/423 - Amino-aldehyde resins