Abstract

Provided are systems and related methods for at least electrically interfacing with a biological material. The systems may be fully automated via use of a robotic positioner configured to facilitate physical handling, accessing and interfacing any one or more of a plurality of independent biological materials. A multi-electrode array algins and electrically connects with a printed circuit board that is positioned by the robotic positioner.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12N 5/0793 - Neurons

Abstract

Compositions and methods for increasing fatty acid and/or oil accumulation in the stems of plants are provided. Constructs including stem cell-specific promoters operably linked to nucleic acids encoding a plastidic phosphoenolpyruvate/phosphate translocator protein and a tonoplast-localized hexose transporter protein are described.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants

Abstract

Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

IPC Classes  ?

• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• A61P 31/04 - Antibacterial agents
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

Imaging strategies remain underdeveloped to maximize information for fluorescence microscopy while minimizing the harm to fragile living systems. The systems and methods set forth herein leverage fluorescence from untreated unlabeled live samples before nonlinear photodamage onset. The imaging modalities are applicable to a wide range of microscopy implementations, and enable a facility-type microscope to freely explore vital molecular biology across life sciences.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present disclosure provides an example method for using an MRI system electrically coupled to a computing device. The method includes generating, via the MRI system, an echo-shifted echo-planar imaging with blip up/down acquisition (“esEPI-BUDA”) pulse sequence including a first radiofrequency (“RF”) pulse and a second RF pulse, the first RF pulse followed by a first echo-train that is interleaved with the first and the second RF pulses, and the second RF pulse followed by a second echo-train such that the first and the second echo-trains have opposite phase-encoding blip gradient polarities to traverse echo planar imaging (“EPI”) k-space in a reversed order. In response to the pulse sequence being generated, the MRI system acquires two k-space datasets within a single shot and corrects image distortion, via the MRI system, based on the two acquired k-space datasets.

IPC Classes  ?

• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

A system for fresh water generation may comprise an intake device positioned above an ocean or sea surface for capture of moisture-laden air. The system may comprise a condenser in fluid communication with the intake device for condensation of liquid water from the moisture-laden air captured by the intake device. The intake device may be disposed at or moveable to a vertical position above the ocean or sea surface where moisture flux of the moisture-laden air is at or above a predetermined value.

IPC Classes  ?

• E03B 3/28 - Methods or installations for obtaining or collecting drinking water or tap water from humid air
• B63J 1/00 - Arrangements of installations for producing fresh water, e.g. by evaporation and condensation of sea water

Abstract

Methods of reducing allograft rejection or the risk of allograft rejection in a subject are described. The methods include metabolically labelling an allograft tissue or organ with a chemical tag (such as dinitrophenyl), transplanting the labelled tissue or organ, and administering to the transplant recipient T regulatory (Treg) cells expressing a chimeric antigen receptor (CAR) specific for the chemical tag. The CAR-expressing Treg cells are stimulated upon binding to the chemical tag displayed on the transplanted tissue or organ, leading to activation of the Treg cells and suppression of effector CD8+ T cells, thereby generating of an immunosuppressive tissue environment that reduces the risk of allograft rejection. Kits that include a chemical tag, engineered CAR Treg cells specific for the chemical tag, and/or a viral vector encoding a CAR specific for the chemical tag are also described.

IPC Classes  ?

• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
• A61K 31/06 - Phenols the aromatic ring being substituted by nitro groups
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

Various examples are provided related to hybrid light-ultrasound fundus imaging. In one example, an ocular imaging system includes a substantially transparent ultrasound transducer; an optical imaging system including a fundus camera sensor aligned with the ultrasound transducer; and one or more control interface components that can enable visualization of an ocular surface and perform filtering on imaging signals generated by the ultrasound transducer operatively connected to the fundus camera sensor. In another example, a method for ocular imaging includes illuminating an ocular surface of an eye with the ocular imaging system; aligning the ultrasound transducer with a lesion on the ocular surface using the optical imaging system; and obtaining ultrasound pulse-echo scan data of the lesion using the ultrasound transducer.

IPC Classes  ?

• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

Abstract

Functionalized spiropyran-based photo-hydrogels that include at least two different spiropyrans are disclosed herein. The disclosed photo-hydrogels may include two spiropyrans with differing chemical properties. In some variations, the spiropyran-based photo-hydrogel includes two functionalized spiropyrans, including a first functionalized spiropyran having a net positive charge and a second functionalized spiropyran having a net negative charge. The net positive and net negative charges are equal and opposite, such that the spiropyran-based photo-hydrogel has an overall net zero charge. In the absence of light, the spiropyrans are in their corresponding merocyanine forms and the photo-hydrogel has a high degree of aggregation. Irradiation, such as exposure to visible light, causes photo-isomerization of the merocyanines into spiropyrans, resulting in an increase in the amount of swelling of the photo-hydrogel. In some implementations, the disclosed photo-hydrogels may be used in a variety of applications such as light-controlled micropumps, artificial eye muscles, cameras, and drug delivery systems.

IPC Classes  ?

• C08F 220/56 - AcrylamideMethacrylamide
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/52 - Hydrogels or hydrocolloids
• C08J 3/075 - Macromolecular gels

Abstract

Provided herein are exosomes (such as modified exosomes) that include or express one or more surface proteins that are covalently linked to an immunomodulatory molecule or a therapeutic molecule. In particular examples, the exosomes are from a cancer cell, a stem cell, or an immune cell. Also provided are methods of making and using the modified exosomes, for example for treating cancer.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 35/13 - Tumour cells, irrespective of tissue of origin
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 40/42 - Cancer antigens
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 35/00 - Antineoplastic agents

Abstract

Methods, apparatus, and storage medium for obtaining a super-elevational resolution ultrasound localization microscopy (ULM) image. One method includes obtaining ultrasound signal acquired from a sample containing microbubbles by a transducer; reconstructing the ultrasound signal to form ultrasound images; filtering the ultrasound images to obtain microbubble signal with a filter; localizing and tracking the microbubbles based on the microbubble signal to obtain microbubble trajectories; performing dynamic localization by selecting in-plane microbubble signal and eliminating out-of-plane microbubble signal based on backscattered amplitudes of the microbubbles; and generating a super-elevational resolution ULM image based on microbubble positions corresponding to the in-plane microbubble signal.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G01S 7/52 - Details of systems according to groups , , of systems according to group

Abstract

A method for treating a subject having a diseased or atrophic state of fibrotic tissue, kidney disease and associated nerve endings, or for promoting tissue regeneration in muscle tissue is accomplished through exposing the tissue with a laser light having a wavelength of about 400 nm to about 700 nm, or more preferably having a wavelength of about 405 nm, about 532 nm, about 635 nm, or a combination thereof. Subsequent to exposure, mesenchymal stem cells can be administered to the subject. After the administration of mesenchymal stem cells, the tissue is further exposed to laser light having a wavelength of about 400 nm to about 700 nm, or a laser light having a single wavelength of about 400 nm to about 700 nm. The mesenchymal cells can be interferon gamma activated.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61N 5/067 - Radiation therapy using light using laser light

Abstract

Various examples are provided related to high dynamic range (HDR) imaging of a retina. In one example, a fundus camera includes an imaging sensor; an ophthalmic lens; and a source of input light. The source can illuminate the retina at sequentially increasing illumination power levels during a series of illumination periods within a pupillary reflex time of the eye. The imaging sensor can capture a corresponding low dynamic range (LDR) image of during each of the series of illumination periods, which can be combined to generate a HDR image of the retina. An external fixation target can be used to capture LDR images at different visual angles to generate HDR images, which can be combined to generate widefield HDR images.

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/14 - Arrangements specially adapted for eye photography
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06V 10/60 - Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model

Abstract

Methods, apparatus, and storage medium for enhancing diffusion-weighted magnetic resonance imaging (MRI) by using steady-state free procession (SSFP) of ultra-short echo time (UTE) and UTE-based magnetization transfer MRI. One method includes, for each of a plurality of data acquisition sequences: for each of a plurality of data acquisition sequences: applying a set of radio-frequency (RF) pulses to interact with transverse magnetization within an imaging volume of an object in a magnetic field, applying a three-dimension (3D) magnetic gradient within the imaging volume, wherein the 3D magnetic gradient comprises a 3D spiral pulse, and acquiring, during the 3D spiral pulse, raw imaging data from the imaging volume; and constructing a raw MRI image based on the raw imaging data acquired from the plurality of data acquisition sequences.

IPC Classes  ?

• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
• G01R 33/48 - NMR imaging systems
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The present invention provides novel DNA molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the DNA molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use. The invention also provides methods for identifying regulatory elements.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 6/00 - Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/09 - Recombinant DNA-technology

Abstract

Disclosed are methods for identifying and optimizing modular synthetic routes to various compounds comprising combining molecular building blocks. Also disclosed are synthetic methods directed to the optimized modular synthetic routes.

IPC Classes  ?

• C07C 17/275 - Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
• C07C 45/68 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton by increase in the number of carbon atoms
• C07F 5/02 - Boron compounds

Abstract

Provided are compositions including a DNA net nanostructure that are useful for the detection of viruses, particularly in lateral flow assay format. Also provided are lateral flow assay test strips and methods of use thereof.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention provides novel DNA molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the DNA molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use. The invention also provides methods for identifying regulatory elements.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

A metal oxide-coated aerogel has an aerogel structure comprising yttria-stabilized zirconia (YSZ) and a coating on the aerogel structure. The YSZ includes at least about 20 mol. % yttria (YO1.5) in zirconia (ZrO2) and the coating comprises a metal oxide selected from the group consisting of silica, alumina, zirconia, and titania. An aerogel composite includes a fibrous material and an aerogel on surfaces and within interstices of the fibrous material, where the aerogel has an aerogel structure comprising yttria-stabilized zirconia (YSZ) and a coating on the aerogel structure that comprises a metal oxide. A method of forming a thermally stable aerogel comprises: forming a gel comprising yttria-stabilized zirconia (YSZ) including at least about 20 mol. % yttria (YO1.5) in zirconia (ZrO2); immersing the gel in a coating solution comprising a metal alkoxide and ethanol; and after the immersion, supercritically drying the gel, thereby forming a metal oxide-coated aerogel.

IPC Classes  ?

• C04B 35/80 - Fibres, filaments, whiskers, platelets, or the like
• C04B 35/624 - Sol-gel processing
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 35/628 - Coating the powders
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof

Abstract

An anatomy of interest, such as the aortic arch, is automatically segmented from magnetic resonance imaging (MRI) data. The segmented anatomy volume is then processed to track or otherwise determine a centerline of the anatomy volume. Based on this centerline, quantitative measures of the anatomy of interest can be computed. The resulting segmented anatomy volume, centerline, and/or quantitative measures can then be displayed to a user or stored for later use and/or processing. The segmented anatomy volume, centerline tracking and quantitative measures can be monitored to determine longitudinal deformations in the subject relative to previous measures from the subject, or relative to normative measures from an age-matched, sex-matched, race-matched, and/or disease-matched cohort.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/00 - Image analysis

Abstract

An electrochemical method of recycling and regenerating transition metal oxides includes heating a mixture of salts to obtain a molten salt solution, and immersing a working electrode, a counter electrode and optionally a reference electrode into the molten salt solution, where the working electrode is electrically connected to a cathode material comprising a transition metal oxide. A voltage is applied to the working electrode, such that electrodissolution of the transition metal oxide occurs and an alkali metal species comprising lithium or sodium ions and a transition metal species comprising transition metal ions are produced in the molten salt solution. During application of the voltage and dissolution of the transition metal oxide, a regenerated transition metal oxide is concurrently electrochemically produced, e.g., in the form of a film or a powder.

IPC Classes  ?

• C25B 1/01 - Products
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• C25B 15/02 - Process control or regulation

Abstract

The expression of the P-glycoprotein (P-gp) efflux transporter at the blood-brain interface impedes BBB penetrance of most small molecules. Designing efflux liabilities out of compounds can be laborious and there is no generalizable approach to transform periphery-limited agents to ones active in the CNS. A target-agnostic, prospective assessment of P-gp efflux using diverse compounds indicated a reduction in molecular size or appending a carboxylic acid that enabled evasion of P-gp efflux in cell-based experiments and in mice. Such strategy was applied to transform a periphery-limited V600EBRAF inhibitor, dabrafenib, into compounds that possess potent and selective anti-cancer activity, but now also evaded P-gp-mediated efflux. When compared to dabrafenib, the compound developed herein (everafenib) has superior BBB penetrance and superior efficacy in an intracranial mouse model of metastatic melanoma, suggesting it as a lead candidate for the treatment of melanoma metastases to the brain and gliomas with BRAF mutation.

IPC Classes  ?

• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Abstract

This disclosure relates to processes for converting saturated polyethylene to at least an alkene product. The processes comprise contacting the saturated polyethylene with three or more catalyst components in a reactor, the reactor comprising an alkene reactant. The three or more catalyst components comprise a metathesis catalyst component, an isomerization catalyst component, and a dehydrogenation catalyst component. Contacting causes at least a portion of the saturated polyethylene to undergo dehydrogenation reactions to form unsaturated polyethylene and at least a portion of the unsaturated polyethylene, or products derived therefrom, to undergo metathesis reactions and isomerization reactions to produce an effluent comprising at least the alkene product.

IPC Classes  ?

• C07C 6/04 - Metathesis reactions at an unsaturated carbon-to-carbon bond at a carbon-to-carbon double bond
• B01J 6/00 - CalciningFusing
• B01J 23/42 - Platinum
• B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
• B01J 35/61 - Surface area
• B01J 35/63 - Pore volume
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/08 - Heat treatment
• C07C 5/373 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen with simultaneous isomerisation

Abstract

A fusion protein composed of Notch1 or Notch4 EGF-like repeats 10-14 fused to human IgG Fc is described. Also provided is a pharmaceutical composition including the fusion protein and use of the fusion protein in methods of inhibiting angiogenesis and treating a disease or disorder.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 27/02 - Ophthalmic agents
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

In one aspect, the disclosure relates to a composition and a catalyst for substantially continuous CO2 capture and reduction from dilute CO2 sources including flue gas, wherein the flux of CO2 captured is substantially equal to the flux of CO2 reduction. The system can comprise integrated CO2 capture and reduction components. An exemplary system includes a composition of a catalyst and electrolytes. The catalyst can comprise supported or unsupported mesh electrodes that comprise Cu, a Cu—Al alloy, and/or a copper oxide. In one aspect, the system includes one or more membranes separating an anodic side from a cathodic side in the system, where the one or more membranes can be a bipolar membrane, an anion exchange membrane, or both, which can reduce or eliminate Cl2 production. In exemplary embodiments, the value-added products can be selected from CO, CH4, C2H4, C2H5OH, CH3COOH, CH3OH, C3H6, and/or H2.

IPC Classes  ?

• C25B 3/26 - Reduction of carbon dioxide
• B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
• C25B 1/23 - Carbon monoxide or syngas
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/03 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/061 - Metal or alloy
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound

Abstract

4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.

IPC Classes  ?

• C07D 231/56 - BenzopyrazolesHydrogenated benzopyrazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Compositions and methods for improving one or more agronomic traits of a plant are provided, which include the use of one or more fatty acids that kill or inhibit the growth of cells in the shoot apical meristem and optionally one or more surfactants. Use of the composition between vegetative growth stage 1 (V1) and vegetative growth stage 6 (V6) is described.

IPC Classes  ?

• A01N 31/02 - Acyclic compounds
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01P 21/00 - Plant growth regulators

Abstract

An electrochemical method of fabricating an adherent and structurally stable multilayer assembly includes forming a metallic interlayer on a base layer, electrochemically passivating some or all of the metallic interlayer, thereby forming a bonding layer comprising a binary oxide, and electrochemically growing a top oxide layer on the bonding layer. An adherent and structurally stable multilayer assembly includes a bonding layer comprising a binary oxide on a base layer, and a top oxide layer comprising a ternary oxide on the bonding layer. The bonding layer may be formed by electrochemical passivation of a metallic interlayer on the base layer.

IPC Classes  ?

• C01D 15/02 - OxidesHydroxides
• C25B 9/09 - Fused bath cells
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

Provided herein is a complete tolerogenic adjuvant composition comprising an effective amount of dexamethasone, an effective amount of rapamycin, and an effective amount of a toll-like receptor agonist and method of using the same to induce regulatory T cell-mediated antigen-specific immunosuppression and treat or reduce the risk of developing an autoimmune disease or condition, allergy, transplant rejection or graft versus host disease.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/35 - Allergens
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

Various systems and methods are provided herein for performing health status detection. In one embodiment, ECG data, acceleration data, and audio data is received via a sensor unit. One or more parameters are extracted from the ECG data. An activity associated with the acceleration data is determined. At least one of an emotional state, a behavioral state, or an infant-caregiving interaction associated with the audio data is detected. One or more physiological and behavioral indicators are determined based on the one or more parameters, the activity, and the emotion state, behavioral state, or the infant-caregiver interaction. A health status corresponding to the physiological and behavioral indicators is outputted.

IPC Classes  ?

• A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/256 - Wearable electrodes, e.g. having straps or bands

Abstract

Compositions and methods for improving one or more agronomic traits of a plant are provided, which include the use of one or more fatty acids, including fatty acid methyl esters and fatty acid ethyl esters, that kill or inhibit the growth of cells in the shoot apical meristem. Use of the composition between vegetative growth stage 1 (VI ) and vegetative growth stage 6 (V6) of the plant is described.

IPC Classes  ?

• A01G 24/20 - Growth substratesCulture mediaApparatus or methods therefor based on or containing natural organic material
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A01N 43/76 - 1,3-OxazolesHydrogenated 1,3-oxazoles
• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• A01N 25/04 - Dispersions or gels
• A01N 25/22 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
• A01P 13/00 - HerbicidesAlgicides

Abstract

22 footprint.

IPC Classes  ?

• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• C04B 18/06 - Combustion residues, e.g. purification products of smoke, fumes or exhaust gases
• C04B 33/132 - Waste materialsRefuse
• C04B 33/135 - Combustion residues, e.g fly ash, incineration waste
• E01C 3/00 - Foundations for pavings

Abstract

This specification discloses systems, methods, and techniques for classifying a grade of cancer represented in a tumor tissue sample. The techniques include obtaining a whole-slide image (WSI) of the tumor tissue sample and partitioning the WSI into a collection of patches. For each patch, (i) a contextualized feature representation of the patch is generated based on intrinsic features of the patch, local dependencies between the patch and a subset of local patches of the WSI, and non-local dependencies between the patch and a subset of non-local patches of the WSI; and (ii) an attention weight is determined for the patch. A WSI-level cancer grade for the tumor tissue sample is predicted based on the contextualized feature representations and the attention weights for the plurality of patches.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06N 5/04 - Inference or reasoning models
• G06N 3/08 - Learning methods
• G06T 7/11 - Region-based segmentation
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 20/00 - Machine learning
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

Provided are methods of making a liquid and liquid vapor-proof material, and relates long-term implantable electronic devices. The method comprises providing a first substrate having a first-side encapsulating layer supported by at least a portion of the first substrate; providing a material onto the first-side encapsulating layer; providing a second substrate having a second-side encapsulating layer supported by at least a portion of the second substrate; covering an exposed surface of the material provided onto the first-side encapsulation layer with the second-side encapsulating layer; wherein said encapsulating layers are substantially defect free so that liquid or liquid vapor is prevented from passing through each of the encapsulating layers; thereby making the liquid or liquid vapor-proof material.

IPC Classes  ?

• A61B 5/283 - Invasive
• A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
• A61B 5/361 - Detecting fibrillation
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

Herein is disclosed a bioinspired approach in which triggered conformational changes are used to control electron transfer (ET) events. Photo-induced conformational rearrangements of a ligand are translated into changes in the coordination geometry and environment about abound metal ion. Taking advantage of the differential coordination properties of CuI and CuII, these dynamics facilitate intramolecular ET from CuI to the ligand to create a CS state. The synthesis and photophysical characterization of CuCl(dpaaR) (dpaa=dipicolylaminoacetophenone, with R═H and OMe) is presented. These ligands incorporate a fluorophore into their framework that gives rise to a twisted intramolecular charge transfer (TICT) excited state. Excited state ligand twisting provides a tetragonal coordination geometry capable of capturing CuII in the CS state when an internal ortho-OMe binding site is present (as in dpaaOMe).

IPC Classes  ?

• C07F 1/08 - Copper compounds
• C07D 213/36 - Radicals substituted by singly-bound nitrogen atoms

Abstract

A system includes a reflector and a radar system positioned opposite from the reflector with an area under test therebetween having a particle-medium mixture. The radar system includes an antenna to emit, at the reflector, a series of chirps within a first electromagnetic signal and to receive a second electromagnetic signal that includes reflected chirps that bounce off the reflector. An ADC converts the second electromagnetic signal to a digital signal containing phase, frequency, and amplitude information. A processing device is to process the digital signal to: detect raw phase data of reflector peaks to be tracked over the reflected chirps; unwrap the raw phase data into a continuous phase-based signal; correct for phase non-linearities within the continuous phase-based signal; and generate, from the corrected continuous phase-based signal, a path-integrated particle number density for the particle-medium mixture.

IPC Classes  ?

• G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
• G01N 11/02 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by measuring flow of the material
• G01S 7/35 - Details of non-pulse systems

Abstract

In one embodiment, the invention relates to a process for producing a crystalline antioxidant comprising: (1) providing an aqueous solution comprising a hydrophilic antioxidant; and a polymer selected from hyaluronate-dopamine, alginate-dopamine, chitosan-dopamine, poly(ethylene glycol) dopamine and their derivatives, or mixtures thereof; (2) forming a liquid droplet of the aqueous solution, the droplet having a diameter, wherein polymer-induced nucleation of the antioxidant occurs in the liquid droplets; (3) crystallizing the crystalline antioxidant by performing at least one of: (a) subjecting the liquid droplet to thermal cycling between a lower temperature and a higher temperature, wherein antioxidant crystal growth occurs at the lower temperature and crystal dissolution occurs at the upper temperature; and maintaining the thermal cycling until the droplet contains one or two antioxidant crystals, and (b) subjecting the liquid droplet to shear deformation using a shear-induced mixing-on-a-chip device, wherein a probability of nucleation and crystallization of each droplet is increased.

IPC Classes  ?

• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

A bidirectional-metal semiconductor field effector transistor (BiD-MESFET) includes an insulating diamond substrate. The BiD-MESFET further includes a p-type diamond drift layer disposed on the insulating diamond substrate and a field oxide layer positioned between a pair of Schottky gate contacts and disposed on the p-type diamond drift layer. A similarly-designed BiD-MOSFET instead employs standard gate contacts and a gate oxide layer disposed on the p-type diamond drift layer on which is disposed the field oxide layer.

IPC Classes  ?

• H10D 30/87 - FETs having Schottky gate electrodes, e.g. metal-semiconductor FETs [MESFET]
• H10D 62/83 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge
• H10D 64/64 - Electrodes comprising a Schottky barrier to a semiconductor

Abstract

, inter alia, inter alia, provide robust protection against Type III CRISPR-Cas immunity.

IPC Classes  ?

• C12N 9/14 - Hydrolases (3.)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A microfluidic device for emulsion switching includes a channel comprising: an inlet for injection of double emulsion droplets; an emulsion switching feature downstream of the inlet for converting the double emulsion droplets directly or indirectly into single emulsion droplets; a manipulation portion downstream of the emulsion switching feature for manipulating and/or modifying the single emulsion droplets, the manipulation portion including a non-wetting inner surface configured to avoid wetting of the single emulsion droplets; and a reforming portion downstream of the manipulation portion for reforming double emulsion droplets from the manipulated or modified single emulsion droplets.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Provided herein are compounds that are potent inhibitors of the Mycobacterium tuberculosis (MTB) RNA polymerase (RNAP), which exhibit significantly reduced activation of the human pregnane X receptor (hPXR), resulting in dramatically reduced C induction of hepatic cytochromes P450 2C9 and 3A4 (CYP2C9, CYP3A4), as well as a number of Phase II metabolism enzymes. Also provided herein are pharmaceutical compositions comprising the compounds, and methods of treating tuberculosis using the compounds.

IPC Classes  ?

• C07D 498/18 - Bridged systems
• A61K 31/5386 - 1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
• A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings
• A61P 31/06 - Antibacterial agents for tuberculosis
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

A microchannel includes a single inlet and a single outlet, a spiral section downstream from the single inlet, a straight section downstream from the spiral section, a detection section downstream from the straight section, and an expansion section downstream from the detection section and disposed between the detection section and the single outlet. The microchannel is to receive fluid having particles. In addition, at least the straight section and the detection section are configured to orient particles within the detection section in an area away from sidewalls of the detection section and into one of a single particle stream or two particle streams. The two particle streams immediately adjacent to each other appear as a single particle stream for optimized focusing and orientation of the particles in a focused stream within the microchannel.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Methods and compositions for treating neurodegenerative disorders comprising crRNA molecules targeting exon1a and/or intron 1 of C9ORF72 and a Cas13 protein or a polynucleotide encoding a Cas13 are provided.

IPC Classes  ?

• A61K 38/46 - Hydrolases (3)
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 9/22 - Ribonucleases

Abstract

This invention relates to ligand exchange proteins comprising the luminal domain of TAP-binding protein-related (TAPBPR), which functions as a MHC class I ligand-exchange catalyst when presented to mammalian cells either as a soluble extracellular protein or as a membrane bound cell surface protein. This may be useful in modulating immune responses, including for example loading immunogenic ligand onto tumors or other disease cells to induce their recognition by T cells. Ligand-exchange proteins and methods for their use are provided. The invention further relates to an approach for generating conditional peptide ligands for a range of disease-related MHC-I allotypes. The present invention relates to chicken and human TAPBPRs and tapasins as well as orthologs thereof, derivatives thereof, and any mutants thereof as well as any combinations thereof. The present invention also relates to placeholder conditional ligands for ligand-exchange reactions across multiple HLA allotypes.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/385 - Haptens or antigens, bound to carriers

Abstract

This disclosure generally relates to signage and sensing schemes for roadways and particularly relates to passive in-vehicle sensing of signages coded on or embedded in road surface or pavement for enhancing roadway safety. In some example implementations, an array of sensors may be arranged in a vehicle. These sensors may be configured to interact with electromagnetic signatures of surface signages to generate detected waveforms, which may be analyzed to generate instructions or warnings to the drivers of the vehicle for altering unsafe driving maneuvers or for responding to upcoming work zones. Various instructions (e.g., slow-down instructions, merging instructions, and the like) or warning information may be associated with features spatially coded in the surface signages patterned on or embedded in the surfaces of the pavement over the roadway. These signages may be designed for construction work zone safety. These signages, for example, may be patterned using electromagnetic materials with local magnetic field and or electric field that can be detected and spatially resolved by the in-vehicle sensors via short-range electromagnetic induction and interactions. Such signage patterns may be formed by spatially arranged strips of such an electromagnetic material.

IPC Classes  ?

• G08G 1/0967 - Systems involving transmission of highway information, e.g. weather, speed limits
• B60Q 5/00 - Arrangement or adaptation of acoustic signal devices
• B60Q 9/00 - Arrangement or adaptation of signal devices not provided for in one of main groups
• E01F 9/30 - Arrangements interacting with transmitters or receivers otherwise than by visible means, e.g. using radar reflectors or radio transmitters

Abstract

Disclosed are single cells coated with a crosslinked alginate hydrogel layer comprising an asymmetrical distribution of cell surface receptor ligands within the alginate coating, as well as methods and devices for preparing the alginate-coated cells, compositions comprising the alginate-coated cells, and methods of using the alginate-coated cells to promote osteogenesis in a subject.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A61L 27/38 - Animal cells
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

A wireless power system includes a transmission resonator and a metamaterial including an array of unit cells. The unit cells are individually adjustable to change a resonance frequency of the array. A controller adjusts unit cells in the array of unit cells to set a resonant mode providing coupling coefficients equal to that of the transmitter resonator and a receiver resonator to yield a paritytime symmetric state of the array, the transmitter resonator and the receiver resonator.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H01F 38/14 - Inductive couplings
• H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
• H04B 5/79 - Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for data transfer in combination with power transfer
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

Methods, apparatus, and storage medium for providing real-time asphalt density and/or moisture content prediction with ground penetrating radar. A method includes using raw data from a ground penetrating radar sensing an asphalt concrete at a location; processing the raw data to obtain processed data; determining an asphalt density of the asphalt concrete at the location based on the processed data according to an asphalt density prediction model; determining a compaction status of the asphalt concrete at the location based on the asphalt density and a target compaction threshold; and outputting the compaction status of the asphalt concrete at the location to an operator for determining whether to continue or stop compacting the asphalt concrete at the location. In another method, moisture content for cold recycling and existing asphalt concrete pavement is predicted in real-time from using raw from data of ground penetrating radar mounted on a vehicle.

IPC Classes  ?

• G01N 22/04 - Investigating moisture content
• E01C 19/26 - Rollers thereforSuch rollers usable also for compacting soil self-propelled or fitted to road vehicles
• G01N 33/38 - ConcreteLimeMortarGypsumBricksCeramicsGlass
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
• G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging

Abstract

The present technology comprises ocular cooling devices for reducing and/or controlling an eye temperature level. The ocular cooling devices may be useful in methods including, but not limited to, treating or preventing an ocular pain, an ocular inflammation, or an intraocular pressure in a subject in need thereof relative to a control. In some embodiments, the ocular cooling devices are portable.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
• A61F 7/02 - Compresses or poultices for effecting heating or cooling
• G01K 7/42 - Circuits effecting compensation of thermal inertiaCircuits for predicting the stationary value of a temperature

Abstract

A methodology is used to quantify implications and/or footprints of carbon, water, and/or nutrients of a particular crop in a region on a large scale and at field-level. A methodology is used to quantify, calculate, and/or visualize cover crop traits, tillage practices, and/or their outcomes at large scale. A methodology is used to accurately derive, estimate, and/or predict large-scale, long-term, and field-level cover crop adoption and biomass information using remote sensing time series.

IPC Classes  ?

• G06Q 30/0202 - Market predictions or forecasting for commercial activities
• G06V 20/10 - Terrestrial scenes

Abstract

Material processing composites, devices, methods of use, and methods of manufacturing using composites having three-dimensional interpenetrating channels separated by porous walls. Such composites include composites having a first flow channel and a second flow channel defined and separated by porous (e.g., nanoporous) walls, wherein the first flow channel and the second flow channels have a three-dimensional interpenetrating structure. The first flow channel and the second flow channel may have a triply periodic minimal surface structure, such as a gyroid or Schwartz surface structure. In some embodiments, the composite is configured for use in hemofiltration, molecular filtration, gas purification, energy storage, or chemical conversion.

IPC Classes  ?

• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires

Abstract

Multiphoton microscopy provides a non-invasive tool capable of monitoring metabolic states and/or the overall health of live cells with improved spatial resolution. A laser light source (e.g., a femtosecond laser) is used to excite one or more fluorophores, harmonophores, or other molecules in a biological sample and photonics are used to image, monitor, and retain cell health. Phototoxicity is reduced by rapidly scanning a laser light source over the sample such that full triplet relaxation in the sample is obtained, thereby reducing phototoxicity.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

A selected surface of the present disclosure is characterized by a two-tier nanostructure: first-tier nanostructures and second-tier nanostructures disposed on at least a cell wall of the first-tier nanostructures. The first-tier nanostructures define a network of cells, each with a cell wall and a recessed core. The core is predominantly formed of a first phase of an additively formed aluminum alloy, and the cell wall is predominantly formed of a second phase of the same additively formed aluminum alloy. A method of forming the two-tier nanostructure includes preferential etching of the core over the cell wall to form a network of open cells, and a self-limiting formation of the second-tier nanostructure to form a plurality of sub-cavities characterized by nanoscale dimensions smaller than the cell opening of a cell.

IPC Classes  ?

• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B22F 3/11 - Making porous workpieces or articles
• B22F 3/24 - After-treatment of workpieces or articles
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

Material processing composites, devices, methods of use, and methods of manufacturing using composites having three-dimensional interpenetrating channels separated by porous walls. Such composites include composites having a first flow channel and a second flow channel defined and separated by porous (e.g., nanoporous) walls, wherein the first flow channel and the second flow channels have a three-dimensional interpenetrating structure. The first flow channel and the second flow channel may have a triply periodic minimal surface structure, such as a gyroid or Schwartz surface structure. In some embodiments, the composite is configured for use in hemofiltration, molecular filtration, gas purification, energy storage, or chemical conversion.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 71/02 - Inorganic material
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

Provided is a method of treating a disorder mediated by claudin-2 and/or claudin-15, particularly an intestinal disorder, such as colitis or enteritis. The method comprises administering to the subject an effective amount of a compound of formula (I), formula (II), or otherwise as described herein or a pharmaceutically acceptable salt thereof. In another aspect, also provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof.

IPC Classes  ?

• C07D 239/06 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/536 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
• C07D 233/24 - Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

A catalyst for hydrosilylation comprises a complex having a certain formula. The catalyst includes an imidazole moiety including at least one pendent substituent having a terminal ethylenic unsaturated group. A method of preparing the catalyst comprises reacting a platinum complex and an imidazole compound in the presence of a base reagent. A composition comprising the catalyst, an unsaturated compound (A), and optionally a silicon hydride compound (B) is further disclosed, along with a method of preparing a hydrosilylation reaction product.

IPC Classes  ?

• B01J 31/22 - Organic complexes
• C08G 77/08 - Preparatory processes characterised by the catalysts used

Abstract

The described technology induces sterility in female animals by a single injection of progestin containing implants formulated to elevate progesterone level for an extended period to neonatal animals. The sterilant can be progesterone or its derivatives which can activate progesterone receptors. Such formulation may be achieved by using a biodegradable copolymer that releases progesterone for more than 10 days. The progesterone-containing implant can be injected intramuscularly, subcutaneously, or intraperitoneally. The progesterone released from the implants over an extended period then prevents the development of uterine glands, thereby irreversibly sterilizing the female animals.

IPC Classes  ?

• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 15/18 - Feminine contraceptives

Abstract

Systems and methods of microscopy include and/or implement a laser configured to output a first beam and a second beam; a first optical system configured to receive the first beam, the first optical system comprising: a first beam splitter configured to split the first beam into a first component and a second component, a first photonic crystal fiber configured to modify a bandwidth of the first component, and a first pulse shaper configured to shape the first component in at least one of a spatial aspect or a temporal aspect, the first pulse shaper including a first diffraction grating, a first achromatic half-wave plate, a first lens, and a first two-dimensional spatial light modulator (SLM); and a second optical system configured to receive the second beam.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/65 - Raman scattering

Abstract

Various examples are provided related to Plasma Beam Lithography (PBL). In one example, a PBL system includes a source of plasma and a pattern generation substrate (PGS) including at least one aperture formed therein. The PGS can receive the plasma and form one or more plasma beam directed at a target substrate for patterning or etching, each plasma beam shaped the same as or similar to a corresponding aperture. In another example, a method includes positioning a PGS adjacent to a target substrate opposite a source of plasma; forming one or more plasma beam directed at the target substrate with each plasma beam shaped the same as or similar to a corresponding aperture; and performing a simultaneous expose-and-etch or single-step writing with the one or more plasma beam to pattern the target substrate. A substrate or pattern or product can be formed using the disclosed system and methodology.

IPC Classes  ?

• H01J 37/32 - Gas-filled discharge tubes
• G03F 1/80 - Etching

Abstract

A structure for changing the attitude of a spacecraft is provided including an elongated member and a plurality of actuators coupled to the elongated member. The elongated member is coupled to the spacecraft. The elongated member has a length and an angular position relative to an axis. The plurality of actuators are configured to deflect the angular position of the elongated member relative to the axis and to alter the length of the elongated member.

IPC Classes  ?

• B64G 1/24 - Guiding or controlling apparatus, e.g. for attitude control
• B64G 1/28 - Guiding or controlling apparatus, e.g. for attitude control using inertia or gyro effect
• B64G 1/44 - Arrangements or adaptations of power supply systems using radiation, e.g. deployable solar arrays

Abstract

The disclosure includes systems and methods for performing gaze-daze-based interaction in virtual reality and mixed reality (XR) environments. An example system includes at least one head-mountable display (HMD) with at least one eye-tracking sensor, and an XR environment with at least one virtual window with a respective level of visual transparency that is responsive to the characteristic gaze depth calculated by the system. The characteristic gaze depth is calculated based on the eye tracking data, and may utilize a noise-reduction model. An example method of creating an XR training environment for users is also disclosed.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

NOxPorfin is an on-demand porphyrin-based photosensitizer, described herein, designed to treat cancer via photodynamic therapy (PDT). A distinct advantage over existing FDA-approved photosensitizers is that NOxPorfin exhibits a suppressed singlet oxygen quantum yield (φΔ = 6%) prior to activation within cancer cells. This property translates to a severely compromised ability to harm healthy tissue. However, in the presence of nitric oxide, a common feature of all tumors, photosensitization increases by 650% (φΔ=45%). In addition, this is accompanied by a 70-fold fluorescence signal enhancement, which we designed to confirm NOxPorfin activation via clinical fluorescence imaging. The efficacy of NOxPorfin was successfully demonstrated in two murine models of cancer. First, we were able to selectively ablate aggressive breast cancer cells without causing collateral damage. Second, we were able to prevent the growth of nascent, non-small cell lung tumors. The latter study has implications in treating metastatic lesions.

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/10 - DispersionsEmulsions
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

A plasma separation device including a blood inlet and a plasma outlet, the blood inlet comprising an inlet tunnel configured for loading a whole blood sample and a first chamber configured for collecting the whole blood sample; the plasma outlet comprising a second chamber for collecting plasma separated from the whole blood; the device comprising an anti-fouling membrane disposed between the blood inlet and the plasma outlet, the anti-fouling membrane comprising a zwitterionic polyurethane or pre-polymer thereof, wherein the zwitterionic polyurethane or pre-polymer thereof comprises a monomeric unit comprising a zwitterion or precursor thereof and optionally a monomeric unit derived from a polyol, wherein the monomeric unit derived from a polyol is present in a molar ratio in a range of about 0 to about 0.80 relative to the combined amount of monomeric unit derived from a polyol and the monomeric unit comprising a zwitterion or precursor thereof.

IPC Classes  ?

• B01D 71/54 - PolyureasPolyurethanes
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• C08G 18/10 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines
• C08G 18/83 - Chemically modified polymers
• G01N 1/40 - Concentrating samples

Abstract

Imidazotetrazines were designed to evade resistance by O6-methylguanine DNA methyltransferase (MGMT) while retaining suitable hydrolytic stability, allowing for effective prodrug activation and biodistribution. One compound, called TABZ, exhibits activity against cancer cells irrespective of MGMT expression and MMR status. TABZ has comparable blood-brain barrier penetrance and comparable hematological toxicity relative to TMZ, while also matching its maximum tolerated dose (MTD) in mice when dosed once-per-day over five days. The activity of TABZ is independent of the two principal mechanisms suppressing the effectiveness of TMZ, making it a promising new candidate for the treatment of GBM, especially those that are TMZ resistant.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil

Abstract

Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

A product, in accordance with one aspect of the present invention, includes a porous first layer having a first porosity, and a porous skin layer having a second porosity that is relatively lower than the first porosity. The skin layer is a self-formed layer. A method, in accordance with one aspect of the present invention, includes contacting a resin with a separator. The resin is exposed to radiation for curing the resin, thereby simultaneously creating a porous first layer and a porous skin layer positioned between the first layer and the separator. The first layer has a first porosity. The skin layer has a second porosity that is relatively lower than the first porosity.

IPC Classes  ?

• H01M 50/491 - Porosity
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 50/414 - Synthetic resins, e.g. .thermoplastics or thermosetting resins
• H01M 50/449 - Separators, membranes or diaphragms characterised by the material having a layered structure

Abstract

A product, in accordance with one aspect of the present invention, includes a porous first layer having a first porosity, and a porous skin layer having a second porosity that is relatively lower than the first porosity. The skin layer is a self-formed layer. A method, in accordance with one aspect of the present invention, includes contacting a resin with a separator. The resin is exposed to radiation for curing the resin, thereby simultaneously creating a porous first layer and a porous skin layer positioned between the first layer and the separator. The first layer has a first porosity. The skin layer has a second porosity that is relatively lower than the first porosity.

IPC Classes  ?

• H01M 50/491 - Porosity
• H01M 50/457 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising three or more layers
• H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes
• H01M 10/52 - Removing gases inside the secondary cell, e.g. by absorption
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 50/411 - Organic material
• H01M 50/431 - Inorganic material

Abstract

Pantoea ananatisPantoea ananatis, thereby conferring pantaphos resistance to the transgenic plant and/or plant material.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C07F 9/38 - Phosphonic acids [R—P(:O)(OH)2]Thiophosphonic acids
• A61K 31/66 - Phosphorus compounds

Abstract

A transcranial implant is used to deliver photodynamic therapy. The transcranial implant may include a frame to be coupled to a skull of a patient, a light source coupled to the frame, and a controller coupled to the frame and in communication with the light source. The controller controls the light source to deliver light to a resection margin-containing region within the patient.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61F 2/28 - Bones

Abstract

Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct co-product of a biorefinery or ethanol facility, or as a stand-alone product produced from an agricultural or forestry biomass feedstock including using, e.g. ethanol waste streams.

IPC Classes  ?

• C12P 7/18 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

Abstract

The disclosure provides example systems, and methods for manufacture and use of indwelling foley catheters allowing patients to manage foley catheters in a way that is discreet, reliable, safe, and easy to use. In some embodiments, systems and methods include a closed system with connectors that securely connect an indwelling foley tubing to a disposable collector pack that can include a gel pack for storing urine. In some embodiments, the system is connected to a textile or garment. In some embodiments, the secure connectors can be disengaged to dispose of and exchange a collector pack, as needed. In some embodiments, a graphical user interface can be integrated with the systems and methods to provide a smart collector pack and foley system that includes one or more sensors, biosensors, or near-field communicators for monitoring one or more selected conditions and transmitting alerts or signals concerning the selected conditions.

IPC Classes  ?

• A61M 25/10 - Balloon catheters
• A61F 5/44 - Devices worn by the patient for reception of urine, faeces, catamenial or other dischargeColostomy devices

Abstract

Disclosed herein are aspects of compounds according to Formula I and Formula II. Also disclosed are pharmaceutical compositions comprising the compounds and method for making and using the compounds. The compounds are useful as autophagy modulators. Additionally, the disclosed compounds may be useful as therapeutics for treating and/or preventing neurodegenerative diseases including Alzheimer's disease.

IPC Classes  ?

• C07D 471/10 - Spiro-condensed systems
• A61P 25/00 - Drugs for disorders of the nervous system
• C07D 487/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems

Abstract

The following relates generally to error detection in voting systems, and, in particular voting systems using optical scan machines. In some embodiments, one or more processors are configured to: (1) capture, with an optical scan machine, original image data; (2) isolate a first subimage of the original image data; (3) associate the first subimage with a first configuration file candidate, wherein the first configuration file candidate is indicated by a configuration file configuring the optical scan machine, and wherein the association is done according to the configuration file; and (4) display the first subimage along with a representation of the first configuration file candidate.

IPC Classes  ?

• G07C 13/02 - Ballot boxes
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• H04N 1/107 - Scanning arrangements using flat picture-bearing surfaces with manual scanning

Abstract

Disclosed are methods for use in treating or preventing pulmonary fungal infections, e.g., in a recipient of a lung transplant.

IPC Classes  ?

• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

In some embodiments, a method of encoding a set of information bits to produce a codeword that encodes the set of information bits for reliable communication is provided. The set of information bits is received. The set of information bits are provided to a plurality of permutation layers separated by neural network processing layers. Each permutation layer accepts an input vector and generates a reordered output vector that is a reordering of the input vector. Each neural network processing layer accepts a vector of input values and generates a vector of output values based on a non-linear function of the vector of input values. The reordered output vector of a final permutation layer of the plurality of permutation layers is provided as the codeword. In some embodiments, a corresponding method of decoding a codeword to retrieve a set of information bits is provided.

IPC Classes  ?

• H03M 13/21 - Non-linear codes, e.g. m-bit data word to n-bit code word [mBnB] conversion with error detection or error correction
• H03M 13/00 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes
• H03M 13/37 - Decoding methods or techniques, not specific to the particular type of coding provided for in groups

Abstract

A system may include an object having a rotational axis. The system may also include a first mass movably mounted to the object and configured to adjust a moment of inertia of the object by translating relative to the object along an inertial path having a first component that is perpendicular to the rotational axis. The system may additionally include a second mass movably mounted to the object and configured to: apply to the object a first torque in a first direction along the rotational axis while the moment of inertia is adjusted above a threshold value and apply to the object a second torque in a second direction along the rotational axis while the moment of inertia is adjusted below the threshold value, by translating relative to the object along a torque path having a second component that is perpendicular to the rotational axis and the first component.

IPC Classes  ?

• B64G 1/36 - Guiding or controlling apparatus, e.g. for attitude control using sensors, e.g. sun-sensors, horizon sensors
• B64C 17/02 - Aircraft stabilisation not otherwise provided for by gravity or inertia-actuated apparatus
• B64G 1/32 - Guiding or controlling apparatus, e.g. for attitude control using earth's magnetic field

Abstract

Disclosed are sinus irrigation compositions and pre-mix compositions comprising a Lactobacillales bacterium such as Lactobacillus sakei and kits containing the same. Also provided are methods of treating sinusitis in a subject by administering to the subject an effective amount of a composition comprising a Lactobacillales bacterium such as Lactobacillus sakei.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• A61P 11/02 - Nasal agents, e.g. decongestants

Abstract

Provided are methods of using a combination of an ion channel prosthetic and an ion channel modulator for treating pulmonary disorders.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 493/08 - Bridged systems
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The present disclosure is directed to a visibly transparent infrared reflector (VTIR) configured for suppression of emitted infrared radiation for personal thermal management and thermal camouflage. The reflector being configured to enable independent control over optical properties in the visible spectral region. The VTIR coating is comprises using a nano-mesh patterning strategy combined with an oxide/metal/oxide (OMO) trilayer structure having an optimized hole size and coating thickness.

IPC Classes  ?

• D06M 23/16 - Processes for the non-uniform application of treating agents, e.g. one-sided treatmentDifferential treatment
• D06M 10/06 - Inorganic compounds or elements
• D06M 101/20 - Polyalkenes, polymers or copolymers of compounds with alkenyl groups bonded to aromatic groups
• D06M 101/32 - Polyesters

Abstract

The present invention relates to crosslinkable ink compositions and the preparation and use thereof.

IPC Classes  ?

• C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
• C09D 11/03 - Printing inks characterised by features other than the chemical nature of the binder
• C09D 11/107 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from unsaturated acids or derivatives thereof

Abstract

Disclosed are methods and compositions for treating or ameliorating a motor neuron disease or condition associated with a spastic paraplegia type 11 pathogenic variant using a Liver X Receptor (LXR) agonist, more particularly to methods and compositions for treating hereditary spastic paraplegias and amyotrophic lateral sclerosis using a LXR agonist.

IPC Classes  ?

• A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A method of analyzing a supplementary cementitious material (SCM) may include obtaining a sample comprising a SCM; submerging the sample in an alkaline or acidic aqueous solution, whereby the sample undergoes dissolution; determining an ion concentration in the alkaline or acidic aqueous solution at a predetermined time after submerging the sample; and predicting the reactivity of the SCM in a cementitious mixture based on the ion concentration. In another implementation, a method of analyzing a SCM may include obtaining a sample comprising a SCM; positioning the sample on a porous substrate in contact with a water supply; measuring a change in water level of the water supply as the sample absorbs water through the porous substrate; and determining water absorption of the sample. The water absorption may be predictive of yield stress and/or viscosity of a cementitious mixture including the SCM.

IPC Classes  ?

• C04B 18/08 - Flue dust
• C04B 14/04 - Silica-rich materialsSilicates
• C01B 33/40 - Clays
• C04B 7/12 - Natural pozzuolanasNatural pozzuolana cements
• G01J 3/46 - Measurement of colourColour measuring devices, e.g. colorimeters
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 18/00 - Use of agglomerated or waste materials or refuse as fillers for mortars, concrete or artificial stoneTreatment of agglomerated or waste materials or refuse, specially adapted to enhance their filling properties in mortars, concrete or artificial stone

Abstract

Described herein are electrochemical methods for producing ammonia. In one aspect, the method involves introducing nitrogen gas at a pressure greater than ambient pressure into an electrochemical cell composed of an electrolyte composition and applying a current to the electrochemical cell to convert nitrogen to ammonia. In one aspect, the electrolyte composition includes (i) an organic solvent, a (ii) a proton donor, and (iii) a salt of lithium, calcium, magnesium, strontium, yttrium, scandium, zirconium, or any combination thereof. The methods described herein provide increased ammonia Faradaic efficiency (FE) while using less energy (i.e., applied current).

IPC Classes  ?

• C25B 1/27 - Ammonia
• C25B 9/05 - Pressure cells
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 11/043 - Carbon, e.g. diamond or graphene
• C25B 11/046 - Alloys
• C25B 13/07 - DiaphragmsSpacing elements characterised by the material based on inorganic materials based on ceramics
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

Conformationally-constrained helicases having improved activity and strength are provided. Methods of making conformationally-constrained helicases having improved activity and strength are provided. Methods of using conformationally-constrained helicases having improved activity and strength are provided.

IPC Classes  ?

• C12N 9/14 - Hydrolases (3.)
• C12N 9/90 - Isomerases (5.)
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Abstract

Methods for improving one or more agronomic traits of a plant by selecting a plant variety that exhibits overcompensation is provided as is a method for producing one or more plant products from a modified plant that exhibits improvements in one or more agronomic traits. The methods may include reducing or inhibiting the biosynthetic production of one or more plant chemical defense compounds prior to removing the plant apical meristem at a time that is known to cause overcompensation in selected plants.

IPC Classes  ?

• A01H 1/00 - Processes for modifying genotypes
• A01H 1/06 - Processes for producing mutations, e.g. treatment with chemicals or with radiation

Abstract

Disclosed is a rapid automated iterative cross-coupling platform that utilizes stable boronate building blocks and isolable boronate ester intermediates. Also disclosed are methods for activating boronate reagents.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C07F 5/04 - Esters of boric acids
• C07B 37/02 - Addition
• C07B 37/04 - Substitution
• C07B 37/10 - Cyclisation
• C07C 69/003 - Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
• C07C 213/10 - SeparationPurificationStabilisationUse of additives

Abstract

The present disclosure relates to a plant or plant part comprising increased expression of a polynucleotide encoding a CYP72A219 polypeptide that confers to the plant or plant part tolerance to HPPD inhibitor herbicides, such as tembotrione or mesotrione. The disclosure further provides kits for identifying herbicide resistant plants and methods for determining whether a plant is herbicide resistant.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae

Abstract

A tunable and reliable accessory for femtosecond ytterbium fiber chirped pulse amplifiers is developed, termed as fiber-optic nonlinear wavelength converter (FNWC), as an adaptive optical source for femtosecond biophotonics. This accessory empowers the laser to produce fiber delivered ˜20 nJ pulses with central wavelength across 950-1150 nm, repetition rate across 1-10 MHz, and pulse width across 40-400 fs. One enabling feature is the surprising suppression of the long-term fiber photodamage in coherent supercontinuum generation using a photonic crystal fiber with large-pitch small-hole lattice. The corresponding integrated laser may widen the access to tunable ultrafast laser technology in biology and medicine.

IPC Classes  ?

• G02F 1/35 - Non-linear optics
• G02F 1/365 - Non-linear optics in an optical waveguide structure

Abstract

The present disclosure relates to methods of making cyclic terpenoids through substrate-controlled catalysis taking place in the presence of a supramolecular capsule.

IPC Classes  ?

• C12P 5/00 - Preparation of hydrocarbons
• C12P 5/02 - Preparation of hydrocarbons acyclic
• C12P 15/00 - Preparation of compounds containing at least three condensed carbocyclic rings

Abstract

This present disclosure is directed to a fiber, said fiber comprising a conductive metal core and a porous polymer sheath embedded with one or more particles which emit thermal radiation, and articles comprising the same.

IPC Classes  ?

• D01F 9/08 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments of inorganic material
• D03D 13/00 - Woven fabrics characterised by the special disposition of the warp or weft threads, e.g. with curved weft threads, with discontinuous warp threads, with diagonal warp or weft
• D03D 15/20 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads

Abstract

Disclosed herein are compositions comprising or consisting of Lactobacillus acidophilus and one or more prebiotics. Also disclosed herein are methods for treating osteoarthritis, inhibiting or preventing cartilage degeneration, and reducing or inhibiting pain-associated depression in subjects with joint pain with compositions comprising or consisting of Lactobacillus acidophilus and one or more prebiotics.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A61K 31/733 - Fructosans, e.g. inulin

Abstract

Embodiments are provided for determining simulated optical microscopy images of formalin-fixed paraffin embedded (FFPE) stained tissue samples from stimulated Raman scattering microscopy (SRSM) images of frozen tissue samples. These embodiments include applying the SRSM images to a first generative model to generate simulated optical microscopy images of thawed, stained tissue samples corresponding to the SRS imaged tissue samples. The simulated optical microscopy images are then applied to a second generative model to generate simulated FFPE microscopy images of the frozen tissue samples. Training methods are also provided to (i) generate the first generative model using paired training datasets of SRSM images and optical microscopy images of thawed, stained tissue samples, with each SRSM image depicting the same respective tissue sample as a corresponding optical microscopy image; and (ii) generate the second generative model using a training dataset of FFPE microscopy images and images output from the first generative model.

IPC Classes  ?

• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G01N 21/65 - Raman scattering
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06V 10/143 - Sensing or illuminating at different wavelengths
• G06V 10/776 - ValidationPerformance evaluation
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

A system for automated bee rearing includes a brood housing system having a hexagonal sheet structure to hold brood and an incubator sized to hold at least a part of the brood housing system and configured to control and maintain predetermined environmental conditions for the incubation of brood contained in the brood housing system. The system also including a larval feeding system to supply a food source to the brood housing system and a transport system to selectively transport the brood housing system between the incubator and the larval feeding system.

IPC Classes  ?

• A01K 49/00 - Rearing-boxesQueen transporting or introducing cages
• A01K 53/00 - Feeding or drinking appliances for bees
• A01K 47/02 - Construction or arrangement of frames for honeycombs
• A01K 67/033 - Rearing or breeding invertebrates; New breeds of invertebrates

Abstract

This application relates generally to robotic control/navigation and is specifically directed to a Torso-dynamics Estimation System (TES) for estimating leaning and twisting torso motions of a seated user and using such estimation or measurement signals to control movement of physical or virtual robotic devices or avatars solely using the user's upper body motion. For example, these signals can be used in lean-to-steer scenarios where the seated user is a rider/driver in a personal mobility device (e.g., powered chair or scooter), vehicle (e.g., car or drone), industrial equipment (e.g., excavator), or humanoid robot/avatar that could be in the physical or virtual worlds. Thus, TES offers a hands-free human-robot interaction for controlling a mobile device.

IPC Classes  ?

• G05D 1/223 - Command input arrangements on the remote controller, e.g. joysticks or touch screens

Abstract

Disclosed are broccoli plant extracts and nutraceuticals including the same that have increased levels of anti-inflammatory chemicals. Also provided are exosomal preparations containing the broccoli plant extracts and nutraceuticals as well as methods of using the broccoli plant extracts and nutraceuticals for treating inflammation and treating or reducing the risk of cancer recurrence in a subject.

IPC Classes  ?

• A61K 36/31 - Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Small molecule inhibitors of the localization of lipoprotein CDE (LolCDE) complex that is found in the membrane of bacteria. Searches for suitable candidates for the LolCDE complex led to the discovery of an inhibitor named lolamycin. Lolamycin specifically targets Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Salmonella typhimurium, and is selective over Gram-negative and Gram-positive commensal bacteria, thereby avoiding perturbation of the gut microbiome.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 31/04 - Antibacterial agents

Abstract

A waypoint, navigation controller and corresponding controlling methods are described, where the controller functions as a multiple input-multiple output, e.g., nonlinear angular velocity and linear speed controller for a land vessel such as a skid-steer vehicle. The controller and the controlling methods may be based on a fuzzy logic controller (alternatively referred to as “fuzzy controller”). The membership functions of the fuzzy controller may employ a trapezoidal structure with a symmetric rule-base. In addition, a Hierarchical Rule-Base Reduction (HRBR) is incorporated into the controller so as to select only the rules most influential on state errors by selecting inputs/outputs, determining the most globally influential inputs, and generating a hierarchy relating inputs via a Fuzzy Relations Control Strategy (FRCS). This disclosure is further directed to a fuzzy logic controller with Hierarchical Rule-Base Reduction (HRBR) and implemented as neural network and training of such a fuzzy logic controller via reinforcement learning based on an ANFIS actor.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• G06N 7/04 - Physical realisation

Abstract

Various examples are provided related to enhanced contrast imaging of a retina. In one example, a fundus camera includes an imaging sensor; an ophthalmic lens; a quarter waveplate positioned on a side of the ophthalmic lens opposite a camera lens; a source of linearly polarized input light; and a linear polarizer disposed between the ophthalmic lens and the camera lens. The source can direct the linearly polarized input light to the quarter waveplate to convert the linearly polarized input light to circularly polarized input light that illuminates a retina. The linear polarizer can receive depolarized output light from the retina and linearly polarized output light converted by the quarter waveplate from helically flipped output light from the retina, and allow polarized output light aligned with the linear polarizer to reach the imaging sensor to provide high contrast fundus images of the retina. The fundus camera can be portable.

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/14 - Arrangements specially adapted for eye photography

Abstract

A photoconductive semiconductor switch includes a diamond substrate and a semi-insulating layer disposed above the diamond substrate. A pair of ohmic contacts are disposed on or above the semi-insulating layer, to receive current or voltage. A buried channel layer is disposed between the diamond substrate and the semi-insulating layer. The buried channel layer can be configured to pass the current or voltage between ones of the pair of ohmic contacts in response to receiving light of a particular wavelength.

IPC Classes  ?

• H01L 31/112 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor
• H01L 31/02 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof - Details
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H04Q 11/00 - Selecting arrangements for multiplex systems

Goods & Services

Imaging platform for tumor removal consisting of an optical device and computer software Surgical imaging tool for tumor resection surgery; Imaging device for tumor resection surgery Clinical research in the field of tumor resection surgery