Abstract

Embodiments in accordance with the present invention encompass a variety of polymers derived from polycyclic olefin monomers, such as hydrocarbon functionalized norbornenes. The polymers so formed function as ionomers and are suitable as anion exchange membrane for fabricating a variety of electrochemical devices, among others. More specifically, the ionomeric polymers used herein are derived from a variety of quaternized amino functionalized norbornene monomers and are lightly crosslinked (less than ten mol %). The membranes made therefrom exhibit very high ionic conductivity of up to 198 mS/cm at 80° C. This invention also relates to using an anion conducting solid polymer electrolyte as the ion conducting medium between the two electrodes and the ion conducting medium within the electrodes acting as the ionic conduit between electroactive material and electrolyte. The electrochemical devices made in accordance of this invention are useful as fuel cells, gas separators, and the like.

IPC Classes  ?

• C08G 61/02 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
• B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
• H01M 50/414 - Synthetic resins, e.g. .thermoplastics or thermosetting resins

Abstract

The invention is directed to mutants of adenosine deaminase 1 (ADA1) that have increased or prolonged stability or catalytic activity relative to wildtype ADA1, as well as compositions comprising the mutants and methods of using the mutants to treat various conditions.

IPC Classes  ?

• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Abstract

Systems and methods for determining microbubble dynamics. The method may comprise introducing at least one microbubble into a vessel. The method may also comprise providing ultrasound waves through an outer surface of the vessel and to at least a portion of the at least one microbubble, wherein the ultrasound waves cause the at least one microbubble to oscillate and emit acoustic waves. The method may further comprise receiving, via at least one receiver, the acoustic waves and generating acoustic emission data based on the acoustic waves. The method may further comprise determining, based at least in part on the acoustic emission data, an acoustic emission frequency of the at least one microbubble. The method may also comprise determining, based at least in part on the acoustic emission frequency, at least one dynamic property of the at least one microbubble.

IPC Classes  ?

• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G01N 29/44 - Processing the detected response signal

Abstract

An exemplary embodiment of the present disclosure provides a system for generating a set of stimulation parameters, the system comprising at least one processor and a memory in communication with the at least one processor and having stored thereon instructions that, when executed by the at least one processor, is configured to cause the system to analyze, using a machine learning model, data from the deep brain stimulation device or an electromyography and generate, in response to analyzing, at least in part, the data, a set of stimulation parameters for deep brain stimulation.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

An exemplary embodiment of the present disclosure provides a method of classifying a plurality of cells, comprising: providing a sample comprising a plurality of cells, the plurality of cells comprising a plurality of cell types; performing a flow cytometry process on the plurality of cells to generate an observation matrix; generating a compensation matrix based on the observation matrix; modifying the observation matrix with the compensation matrix to generate a compensated observation matrix; and classifying each of the plurality of cells into a cell type based on the compensated observation matrix.

IPC Classes  ?

• G01N 15/1434 - Optical arrangements
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/10 - Investigating individual particles
• G01N 15/1429 - Signal processing

Abstract

Embodiments of the present disclosure can perform more accurate localization and tracking in various applications where wireless signals are employed while overcoming bandwidth limitations in the realm of precise wireless ranging. In one aspect, a method of performing wireless contactless sensing is provided. The method can include: filtering a received signal using a filter to select non-contiguous frequency bands, determining phase information for the selected non-contiguous frequency bands, determining a time domain response of the determined phase information for the selected non-contiguous frequency bands, and determining a location of a target based on the determined time domain response.

IPC Classes  ?

• G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation

Abstract

The present disclosure relates to compounds, compositions, and methods for inhibiting Nox4 signaling. Also described are methods of treating fibrotic disorders (e.g, pulmonary fibrosis, heart fibrosis, kidney fibrosis, liver fibrosis, skin fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, scleroderma or systemic sclerosis), acute respiratory distress syndrome (ARDS), and cancer (e.g, a sarcoma, a carcinoma, a hematological cancer, a solid tumor, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, non-small cell lung carcinoma, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanoma, glioma, leukemia, lymphoma, chronic myeloproliferative disorder, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm (myeloma)) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/13 - Amines, e.g. amantadine
• A61K 31/33 - Heterocyclic compounds

Abstract

e.ge.g.e.g., a sarcoma, a carcinoma, a hematological cancer, a solid tumor, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, non-small cell lung carcinoma, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanoma, glioma, leukemia, lymphoma, chronic myeloproliferative disorder, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm (myeloma)) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

IPC Classes  ?

• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

An exemplary embodiment of the present disclosure provides a current source converter, comprising a transformer, a first circuit, and a second circuit. The transformer can comprise a first winding, a second winding, and a third winding. The first circuit can be electrically coupled to the first and second windings. The first circuit can comprise a battery port and a photovoltaic (PV) port. The battery port can be configured to interface with one or more batteries. The PV port can be configured to interface with one or more PV modules. The second circuit can be electrically coupled to the third winding. The second circuit can comprise an alternating current (AC) port configured to interface with an AC load.

IPC Classes  ?

• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
• H02M 7/797 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

An exemplary system and method are disclosed for a shape similarity search via a trained AI model configured on both part shape and material properties, among others, to allow for searching against a database of parts to identify a set of candidate like models or parts. In some embodiments, the trained AI model can learn the capabilities of a manufacturing facilities to which the trained AI model can be interrogated to identify a candidate manufacturer for a given part having both part shape and material properties. The operation can be performed via federated learning for improved privacy.

IPC Classes  ?

• G05B 19/4093 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by part programming, e.g. entry of geometrical information as taken from a technical drawing, combining this with machining and material information to obtain control information, named part programme, for the NC machine
• G05B 19/4097 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM
• G06F 16/903 - Querying

Abstract

Embodiments of the present disclosure include improvements to millimeter wave backscatter RFID technology for rotational sensing. Embodiments of the present disclosure leverage the polarization mismatch of linearly polarized antennas to capture rotational motion with high accuracy. One embodiment described herein includes utilization of a four-antenna system, each featuring a different modulation frequency. This configuration allows for independent extraction of rotational information by observing the changes in signal amplitudes as the angle of rotation varies. With a polarization offset of 15° between successive antennas, the backscatter channels trace distinct curves, enabling the resolution of angular ambiguities.

IPC Classes  ?

• G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips

Abstract

Organ-on-chip system, including a bio-engineered lung region that is functionally connected to a bio-engineered lymphatic region via a functionalized connection region. The bio-engineered lung region includes cultured or transplanted lung cells/tissue, which can mimic in vivo lung function, and the bio-engineered lymphatic region includes lymphatic cells/tissue, which can mimic in vivo lymphatic function. The connection region allows for stimuli and cell secretions to be transported between the lung region and the lymphatic region to confer immune competency to the lung region, as the lymphatic region can generate an immune response based on stimuli received from the lung region, for example, in response to infections or therapeutic agents

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
• C12N 5/078 - Cells from blood or from the immune system
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

System and method for collection and separation of human waste are described. The system can include a vessel (102) configured to receive human waste and a solids separator (106). The solids separator can include a vacuum tank as well as an inlet chamber formed within the vacuum tank at the top portion, a solids containment portion formed in the base of the vacuum tank and positioned centrally within the vacuum tank, a liquid containment portion formed in the base of the vacuum tank and contained within the vacuum tank surrounding the solids containment portion, and a separating filter having a cylindrical tubular shape and extending from the inlet chamber outlet to the solids containment portion. The separating filter forming a central separation volume within the vacuum tank. The inlet chamber is configured to receive the combined waste via an inlet (132) and to direct the combined waste to the central separation volume. The liquid portion of the combined waste allowed to flow through the separating filter to an outer portion surrounding the central separation volume and to collect in the liquid containment portion of the base. The solids portion of the combined waste contained within the central separation volume and collected in the solids containment portion of the base.

IPC Classes  ?

• C02F 11/128 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering using batch processes
• C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated
• E03D 5/014 - Special constructions of flushing devices combined with movable closure elements in the bowl outlet with devices for separate removal of liquids and solids

Abstract

In a method of making an electrode, a binder is dissolved in a solvent to form a solution. An Nb2O5 hydrate-based electrode material powder is suspended in the solution to form a slurry. A predetermined thickness of the slurry is dispensed onto a conductive member so that the slurry has a mass loading in a range of 1 mg cm−2 to 2 mg cm−2. The conductive member and the slurry are dried to form the electrode. A battery includes an anode, a cathode, an electrolyte and a separator. The anode includes a graphite-modified Nb2O5 composite electrode material powder applied to a conductive member. The electrolyte is in electrical communication with the anode and the cathode. The separator is permeable to the electrolyte and is disposed between the anode from the cathode.

IPC Classes  ?

• C01G 33/00 - Compounds of niobium
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/66 - Selection of materials

Abstract

An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.

IPC Classes  ?

• G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
• G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements

Abstract

A shape-morphing structure includes a cold draw programmable grayscale digital light processing 3D printed unitary hinge component comprising at least one glassy state portion and at least one rubbery state portion. The at least one glassy state portion has a glassy state recovery temperature and the at least one rubbery state portion has a rubbery state recovery temperature and different than the glassy state recovery temperature.

IPC Classes  ?

• E05D 1/02 - Pinless hingesSubstitutes for hinges made of one piece
• B33Y 80/00 - Products made by additive manufacturing
• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
• C09D 7/63 - Additives non-macromolecular organic
• C09D 133/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
• F16C 11/04 - Pivotal connections

Abstract

A sensing layer composition is provided. The sensing layer composition is particularly suited to be adhered to at least one side of one or more waveguide channels in/on a waveguide chip of an interferometric system. The sensing layer composition is adapted to bind or be selectively disturbed by one or more fluoro-containing substances via optical interferometric analysis.

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
• G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics

Abstract

An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.

IPC Classes  ?

• G01C 3/06 - Use of electric means to obtain final indication
• G01C 3/16 - Measuring marks
• G01C 3/30 - Measuring distances in line of sightOptical rangefinders using a parallactic triangle with fixed angles and a base of variable length at, near, or formed by, the object with provision for reduction of the distance into the horizontal plane with adaptation to the measurement of the height of an object, e.g. tacheometers
• G21C 3/54 - Fused salt, oxide, or hydroxide compositions
• G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
• G21C 9/00 - Emergency protection arrangements structurally associated with the reactor
• G21C 9/02 - Means for effecting very rapid reduction of the reactivity factor under fault conditions, e.g. reactor fuse

Abstract

A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2−] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2−] for the reversible CO2 sorption and desorption.

IPC Classes  ?

• B01D 53/86 - Catalytic processes
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves

Abstract

An exemplary machine learning-based system and method are disclosed for a clinical tool that can provide a comprehensive prediction of ovarian cancer propensity using metabolite and metabolomic profiles acquired from ultra-performance liquid chromatography, high-resolution mass spectrometry (UPLC-MS) analysis. Each serum sample may be independently processed through two different columns (HILIC and C18 reversed phase). Different ionization modes (negative and positive) may be used. The clinical tool can validated to provide successful prediction of ovarian cancer by over 90%. Ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) and the like can be used.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 20/00 - Machine learning

Abstract

A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.

IPC Classes  ?

• G21C 17/108 - Measuring reactor flux
• G01T 3/00 - Measuring neutron radiation
• G01T 7/00 - Details of radiation-measuring instruments

Abstract

A sensing layer composition is provided. The sensing layer composition is particularly suited to be adhered to at least one side of one or more waveguide channels in/on a waveguide chip of an interferometric system. The sensing layer composition is adapted to bind or be selectively disturbed by one or more fluoro-containing substances via optical interferometric analysis.

IPC Classes  ?

• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods

Abstract

Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

An exemplary embodiment of the present disclosure provides a reverse selective O2/H2 (RSOH) membrane having an O2/H2 permselectivity of greater than unity.

IPC Classes  ?

• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 69/14 - Dynamic membranes
• H01M 8/0202 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors

Abstract

A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.

IPC Classes  ?

• G21C 17/025 - Devices or arrangements for monitoring coolant or moderator for monitoring liquid coolants or moderators for monitoring liquid metal coolants

Abstract

An example method for fabricating an interconnect includes using the spontaneous deposition of a vapor-phase monomer of parylene onto a workpiece to form a parylene polymer layer or a build-up structure of layers in the workpiece for use in device or component fabrication, electronic manufacturing, encapsulation, and packaging, or integration packaged substrate, e.g., semiconductor devices, e.g., chiplets, via advanced multi-surface, interconnects. The example method further includes planarizing or over-planarizing the polymer to expose surfaces of a metal layer, forming additional metal layers, and introducing additional vapor monomer. An example device includes a high-density interconnect wiring structure, including a high-density metal wiring with a first wire and a second wire, and a dielectric layer formed between the first metal wire and the second metal wire, wherein the dielectric layer is conformally applied and spontaneously deposited.

IPC Classes  ?

• H01L 21/768 - Applying interconnections to be used for carrying current between separate components within a device
• H01L 23/528 - Layout of the interconnection structure
• H01L 29/66 - Types of semiconductor device

Abstract

An optical microendoscopy includes an endoscopic probe that has a plurality of integrated fiber optics for uniform illumination and an array of gradient index (GRIN) lenses. The GRIN lenses are configured to capture a reflected light field from one or more on-axis sampling of the reflected light field and two or more off-axis sampling of the reflected light field

IPC Classes  ?

• A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• G02B 3/00 - Simple or compound lenses
• G02B 23/24 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes

Abstract

Disclosed herein is a synthetic memory system, comprising: a recombinase; a modified transcription factor; and a first nucleic acid comprising a first attachment site, a second attachment site, and a target gene between said first attachment site and said second attachment site; wherein at least one of the first attachment site and the second attachment site comprises a modified DNA operator to which the modified transcription factor can reversibly bind; and wherein, when the modified transcription factor is bound to the modified DNA operator, the recombinase is blocked from binding to the attachment site comprising said modified DNA operator.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

An exemplary embodiment of the present disclosure provides a method of sensing at least one characteristic of an analyte comprising: flowing media with the analyte through one or more microcavities; energizing the microcavity; and sensing at least one of the characteristics of the analyte via interrogation of the energized microcavity. Each of the one or more microcavities can comprise: a first mirror on a first planar surface; a second mirror on a second planar surface opposing the first planar surface; and at least one spacer between the first and second mirrors. The first mirror, second mirror, and at least one spacer can define a channel having an inlet and an outlet. The first and second mirrors can be positioned between the inlet and outlet.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

In a joint movement device for selective flexion and extension of a joint, a tendon is disposed adjacent to the first and second joint members. A tendon securing device is secured to the second joint member, the tendon being secured to the tendon securing device. At least one phalange ring is secured to a joint member and includes a tending routing mechanism configured to route the tendon through the phalange ring. An actuator is coupled to the tendon and pulls the tendon inwardly to cause the joint to flex. An elastic member is coupled to the phalange ring and tendon securing device and applies an extension force thereto, thereby causing the joint to extend when the actuator releases the tendon.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 9/00 - Programme-controlled manipulators
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 13/00 - Controls for manipulators
• B25J 15/06 - Gripping heads with vacuum or magnetic holding means

Abstract

Delivery of oligonucleotides and other agents to tumor microenvironments is challenging due to their rapid clearance, nuclease susceptibility, and inability to traverse plasma membranes, impeding their effective use for the treatment of a variety of disorders. Disclosed herein is a self-agglomerating nanohydrogel and methods of delivering an agent as well as methods of treating cancer with the nanohydrogel.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

A method for treating a neuropsychiatric or neurological disorder by inducing neurological response in a subject, the method comprising: selecting a frequency for application of non-invasive brain stimulation to which a subject is to be exposed; exposing the subject to the non-invasive sensory stimulation at the selected frequency in a range of about 5-100 Hz.

IPC Classes  ?

• A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis

Abstract

A method comprising providing a training data set to a machine learning (ML) system, the training data set indicative of density functional theory (DFT) data for a plurality of materials, the DFT data representing atomic configurations for the plurality of materials, determining a fingerprint for the atomic configuration for each of the plurality of materials, inputting the fingerprints into a machine learning system, generating, with the machine learning system, electron charge density data for the plurality of materials, inputting the electron charge density data and the fingerprint into a machine learning system, and predicting, with the machine learning system, one or more DFT properties of the plurality of materials.

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

An integrated voltage regulators (IVRs) and methods for fabricating IVRs that improve the integration of passive components such as inductors.

IPC Classes  ?

• H01F 17/04 - Fixed inductances of the signal type with magnetic core

Abstract

A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

IPC Classes  ?

• C07K 14/755 - Factors VIII
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
• C12N 15/86 - Viral vectors

Abstract

A coupon sampler for a reactor system includes a lower assembly having an in-line portion configured to receive a flow of a molten salt, and a lower assembly pipe portion extending transverse from the in-line portion and defining a lower channel therethrough. The coupon sampler further includes an upper assembly fluidically coupled with the lower assembly. The upper assembly includes an upper assembly pipe portion defining an upper channel therethrough and cooperating with the lower channel to define a sampling channel of the coupon sampler. The coupon sampler further includes a coupon device disposed fully within the sampling channel. The coupon sampler further includes an actuation mechanism operatively coupled with the coupon device and configured to move the coupon device axially into and out of the flow of the molten salt.

IPC Classes  ?

• G01N 1/14 - Suction devices, e.g. pumpsEjector devices
• G21C 17/022 - Devices or arrangements for monitoring coolant or moderator for monitoring liquid coolants or moderators
• G21C 17/06 - Devices or arrangements for monitoring or testing fuel or fuel elements outside the reactor core, e.g. for burn-up, for contamination

Abstract

A method for predicting polymer properties that can include converting chemical fragments from a plurality of first polymers into standardized data strings, separating each of the standardized data strings into one or more tokens, predicting, via a first machine learning algorithm, one or more tokens from each of the standardized data strings, computing, via a processor device, one or more unique fingerprints for each of the standardized data strings, and mapping, via a second machine learning algorithm, one or more properties of the plurality of first polymers and one or more properties of a plurality of second polymers to the one or more unique fingerprints.

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G01N 33/44 - ResinsPlasticsRubberLeather
• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

A structured adsorbent assembly is described, which is usefully employed for pressure swing adsorption (PSA) processing of ambient air to generate high purity oxygen. The structured adsorbent assembly in various implementations may include cellulosic carbon molecular sieve fibers formed by spinning of precursor cellulose followed by pyrolysis of the spun fibers, as an argon-selective adsorbent, or AgX zeolite contained on and/or in polymeric fibers, as an argon-selective adsorbent, and such argon-selective adsorbents may be in combination with nitrogen-selective adsorbent such as LiX zeolite contained on and/or in polymeric fibers. The structured adsorbent assembly may be employed in PSA systems and processes to achieve highly efficient and economic generation of high purity oxygen for applications such as distributed gasification power generation.

IPC Classes  ?

• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01D 53/047 - Pressure swing adsorption
• B01J 20/18 - Synthetic zeolitic molecular sieves
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C01B 13/02 - Preparation of oxygen

Abstract

A coupon sampler for a reactor system includes a lower assembly having an in-line portion configured to receive a flow of a molten salt, and a lower assembly pipe portion extending transverse from the in-line portion and defining a lower channel therethrough. The coupon sampler further includes an upper assembly fluidically coupled with the lower assembly. The upper assembly includes an upper assembly pipe portion defining an upper channel therethrough and cooperating with the lower channel to define a sampling channel of the coupon sampler. The coupon sampler further includes a coupon device disposed fully within the sampling channel. The coupon sampler further includes an actuation mechanism operatively coupled with the coupon device and configured to move the coupon device axially into and out of the flow of the molten salt.

IPC Classes  ?

• G01N 17/04 - Corrosion probes
• G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
• G21C 3/18 - Internal spacers or other non-active material within the casing, e.g. compensating for expansion of fuel rods or for compensating excess reactivity
• G21C 3/54 - Fused salt, oxide, or hydroxide compositions
• G21C 17/017 - Inspection or maintenance of pipe-lines or tubes in nuclear installations

Abstract

An exemplary embodiment of the present disclosure provides a cardiovascular sensing system, comprising a sensor, an external antenna, and a controller. The sensor can be configured to be worn by a user. The sensor can comprise an inductive capacitive (LC) circuit. The sensor can be configured to deform in response to a strain induced by vibrations of the heart of the user. The external antenna can be inductively coupled to the sensor. The external antenna can be configured to receive a signal from the LC circuit. The controller can be configured to determine a seismocardiogram (SCG) of the user based, at least in part, on the signal received by the LC circuit.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

An exemplary system and method for enhanced structural and thermal structure having an engineered thermal transition zone that integrates with an energy pile section having foundation pile for retaining engineered material or soil and thermal cooling loop that circulate through the material. An apparatus includes an outer surface extending between a first end and a second end of the section; an inner surface spaced apart and radially inward from the outer surface and defining a central channel of the apparatus; a thermal transition zone extending between the outer surface and the inner surface, the thermal transition zone configured to facilitate heat transfer between the inner surface and the outer surface; and a conductive conduit extending through at least the thermal transition zone from the first end to the second end of the apparatus.

IPC Classes  ?

• E02D 31/00 - Protective arrangements for foundations or foundation structuresGround foundation measures for protecting the soil or the subsoil water, e.g. preventing or counteracting oil pollution
• E02D 5/24 - Prefabricated piles

Abstract

An exemplary embodiment of the present disclosure provides a method of characterizing a plurality of cells, comprising: providing a sample comprising the plurality of cells; obtaining a plurality of images of the plurality of cells, each image taken at a different point in time, each image comprising a plurality of pixels, each pixel represented by an image value; and characterizing the plurality of cells based, at least in part, on the image values.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present disclosure relates to systems and methods for nucleic acid storage that can be used under ambient conditions economically. In one implementation, the system may include a cartridge. The cartridge may include a first surface and a second surface opposing the first surface. The cartridge may include a chamber disposed (i) parallel to the first surface and the second surface and (ii) between the first surface and the second surface. The chamber may be configured to receive a blotter substrate. The cartridge may also include at least one opening disposed in the first surface above and interfaces with the chamber. The opening may be configured to receive a permeable membrane.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01L 9/00 - Supporting devicesHolding devices

Abstract

Systems and methods for controlling power converter system. The system comprises a DC bridge electrically coupled to a DC power source. The system further comprises an AC bridge. The system further comprises a transformer comprising a primary winding interfacing with the DC bridge and a secondary winding interfacing with the AC bridge. The system also comprises a controller configured to control the AC and DC bridges to convert a DC voltage from the DC power source to an AC voltage at an output of the AC bridge. The controller is configured to control the DC bridge to provide an input voltage to the primary winding of the transformer. The input voltage comprises a positive voltage portion and a negative voltage portion. The controller causes the AC bridge to flip a polarity of the output.

IPC Classes  ?

• H02M 7/217 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

A power converter, comprising a DC bridge, a first transformer, a plurality of AC bridges, and a controller. The DC bridge can be electrically coupled to a DC power source. The first transformer can comprise a primary winding electrically interfacing with the DC bridge and a plurality of secondary windings. The plurality of AC bridges can be electrically coupled in series, wherein each of the plurality of AC bridges electrically interfaces with a respective secondary winding of the plurality of secondary windings. The controller can be configured to control the DC bridge and the plurality of AC bridges to convert DC power from the DC power source having a voltage level at a first magnitude to DC or AC power having a voltage level at a second magnitude greater than the first magnitude at an output of the plurality of AC bridges.

IPC Classes  ?

• H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 7/5387 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
• H02M 1/10 - Arrangements incorporating converting means for enabling loads to be operated at will from different kinds of power supplies, e.g. from AC or DC
• H02J 3/36 - Arrangements for transfer of electric power between ac networks via a high-tension dc link

Abstract

Systems and methods for cooling air with an air conditioning. The system comprises a first thermally responsive liquid having a first lower critical solution temperature (LCST) configured to be separated into a first water-scarce phase liquid and a first water-rich phase upon liquid heating. The system further comprises a first heater configured to heat the first thermally responsive liquid to a temperature that is at least the first LCST to separate the first thermally responsive liquid into the first water-scarce phase liquid and the first water-rich phase liquid. The system may also comprise a closed loop air system configured to circulate air. The first water-scarce phase liquid may be configured to absorb moisture from the air and the first water-rich phase liquid may be configured to desorb water into the air to cause cooling through evaporative cooling.

IPC Classes  ?

• F24F 3/14 - Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatmentApparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by humidificationAir-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatmentApparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by dehumidification
• F24F 5/00 - Air-conditioning systems or apparatus not covered by group or
• F24F 12/00 - Use of energy recovery systems in air conditioning, ventilation or screening

Abstract

An exemplary embodiment of the present disclosure provides a heat exchanger comprising a chamber and a channel system located within the chamber. The channel system can comprise a repeating set of a first end, a second end, and a plurality of channels between the first end and the second end. A physical property of the plurality of channels can vary from the first end to the second end. A plurality of distribution manifolds can redirect at least a portion of the liquid phase of the first fluid to a plurality of bypass channels. The first fluid can flow through the plurality of channels, and the second fluid can flow through the chamber external to the plurality of channels, which can result in a transfer of heat.

IPC Classes  ?

• F28D 7/16 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being arranged in parallel spaced relation
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A multifocal scanning microscopy (MSM) for super-resolution imaging was developed with multicolor acquisition and minimal instrumental complexity. MSM implements a stationary, interposed multi-focal multicolor excitation by exploiting the motion of the specimens, realizing super-resolution microscopy through a general epi-fluorescence platform without compromising the image-scanning mechanism or inducing complex instrument alignment. The system is demonstrated with various phantom and biological specimens, and the results present effective resolution doubling, optical sectioning, and contrast enhancement. MSM, as a highly accessible and compatible super-resolution technique, may offer a promising methodological pathway for broad cell biological discoveries.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes
• H04N 23/951 - Computational photography systems, e.g. light-field imaging systems by using two or more images to influence resolution, frame rate or aspect ratio

Abstract

A body can be configured to be selectively morphable. One or more body support members can be operatively connected to an outer surface of the body. The one or more body support members can be arranged in a pattern to define at least one morphing region. A contracting member (e.g., a shape memory polymer) can be operatively connected to the outer surface of the body. When activated, the contracting member can contract, which can cause the body to morph (e.g., bend) from a non-activated configuration into an activated configuration.

IPC Classes  ?

• B25J 9/14 - Programme-controlled manipulators characterised by positioning means for manipulator elements fluid
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

A light-field microscopy system includes a light-field microscope, and an image processing system configured to receive images from the light-field microscope and perform a hybrid point-spread function (PSF) operation using a hybrid point-spread function that comprises numerical profiles that are adjusted by experimental positions acquired from an experimentally recorded PSF.

IPC Classes  ?

• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 3/00 - Simple or compound lenses
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Systems and methods for locking an external sheath in place. The system comprises a steerable stylet. The system further comprises an external sheath configured to removably house at least a portion of the steerable stylet. The system also comprises at least one steerable stylet controller configured to control the movement of the steerable stylet and the external sheath in at least one dimension.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

Exemplary engineered synthetic genetic constructs are disclosed that can induce high levels of gene expression in response to changes in metabolism that are unique to solid tumors. These synthetic genetic constructs, hereafter referred to as promoters, can function in human cells, and can be used to specify or enhance the activity of chimeric antigen receptor (CAR) T cell therapies. CAR-T cell therapies are an important class of immunotherapies that is predicted to grow to be a 15B market by 2028 in the US. CAR-T cells and other autologous immune cell therapies have been shown to be deactivated by adenosine, an immunosuppressive small metabolite that accumulates to high levels in solid tumors. Accumulation of adenosine (e.g., ribonucleoside adenosine) can trigger a CREB-mediated signaling pathway to suppress the function of immune cells in solid tumor environments.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 38/19 - CytokinesLymphokinesInterferons
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

A dynamic seal for a biological vessel, comprising an inner frame and a shape memory layer. The inner frame can have an annular shape and can comprise an outer surface. The shape¬ memory layer can be disposed around an outer surface of the inner frame. The shape-memory layer can be configured to transition between a compressed state and an expanded state. The dynamic seal can be configured to be inserted into a vessel, such that when the shape-memory layer is in the compressed state, at least one gap is present between the shape-memory layer and an inner wall of the vessel, and the shape-memory layer is configured to transition to the expanded state to fill the at least one gap.

Abstract

An adaptive seal includes an attachment configured to attach to a replacement heart valve to close gaps between the replacement heart valve and a patient's own and surrounding structure to reduce or to prevent paravalvular leakages.

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts

Abstract

Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration/exfiltration) in a processing pipeline.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
• G01J 5/10 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
• G05D 1/689 - Pointing payloads towards fixed or moving targets
• G05D 105/80 - Specific applications of the controlled vehicles for information gathering, e.g. for academic research
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 20/10 - Terrestrial scenes
• G06V 20/17 - Terrestrial scenes taken from planes or by drones
• G06V 20/64 - Three-dimensional objects

Abstract

Disclosed herein are hydrogel structures and methods of making and use thereof. For example, disclosed herein are methods of making a device comprising a hydrogel matrix and a first chamber in the hydrogel matrix, the hydrogel matrix being derived from a prepolymer and the first chamber being perfusable. The methods can, for example, comprise blocking a first portion of a pre-polymerization solution with a first photomask, the pi-polymerization solution comprising the prepolymer, such that the pre-polymerization solution comprises an exposed portion and a first blocked portion. The methods can further comprise irradiating the exposed portion of the pi-polymerization solution and the first photomask with electromagnetic radiation, the first photomask being substantially opaque to the electromagnetic radiation. In some examples, the prepolymer within the exposed portion of pre-polymerization solution photopolymerizes to form the hydrogel matrix and the prepolymer within the first blocked portion does not photopolymerize and forms the first chamber.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

Disclosed herein natural gas power generating systems comprising a post-combustion carbon capture (PCC) unit configured to remove carbon dioxide from a waste gas to create a flue gas, a direct air capture (DAC) unit configured to adsorb carbon dioxide from an atmospheric gas, and a compression unit configured to receive at least one of: (i) carbon dioxide gas from the first carbon dioxide rich outlet line and (ii) carbon dioxide gas from the second carbon dioxide rich outlet line to create a compressed carbon dioxide product. The DAC unit can further generate steam using a heat exchange with steam generated by a HRSG. The DAC unit can further comprise a sorbent module containing the sorbent bed. The sorbent module can have a carbon capture state configured to adsorb carbon dioxide and a regeneration state configured to contact steam with the sorbent bed.

IPC Classes  ?

• B01D 53/62 - Carbon oxides

Abstract

In an embodiment, metal-organic nanowires or nanofibers comprising polymer chains with around 100 or more repeat units are synthesized. The metal-organic nanowires or nanofibers are exposed to a reactive gas at a temperature in excess of around 100° C. and at a pressure in the range from around 0.001 to around 100 atmospheres.

IPC Classes  ?

• D06M 11/34 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with oxygen, ozone or ozonides
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 50/434 - Ceramics
• H01M 50/44 - Fibrous material

Abstract

The invention is directed to methods of improving the therapeutic efficacy of mesenchymal stromal cells (MSCs) for use in treating osteoarthritis (OA), and more specifically to methods of altering levels of certain proteins, phospho-proteins, genes, and/or MSC-secreted cytokines, chemokines, and/or growth factors in order to improve therapeutic efficacy, as well as methods of distinguishing and classifying MSCs as being highly therapeutic or less therapeutic based on levels of certain phospho-proteins and/or MSC-secreted cytokines, chemokines, and/or growth factors and methods of treating a subject having OA with MSCs having improved therapeutic efficacy.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

An exemplary wireless soft scalp electronic system and method are disclosed that can actuate commands for a brain-machine interface (BMI) or brain-computer-interface (BCI) by performing real-time, continuous classification. e.g., via a trained neural network, of motor imagery (MI) brain signals or of steady-state visually evoked potential (SSVEP) signals. In some embodiments, the exemplary system is configured as a low-profile, portable system that includes microneedle electrodes that can acquire EEG signals for a brain-machine interface controller. The microneedle electrodes may be configured as soft imperceptible gel-less epidermis-penetrating microneedle electrodes that can provide improved contact surface area and reduced electrode impedance density, e.g., to enhance EEG signals and the signal classification accuracy. The microneedle electrodes can be further integrated with soft electronics that can be mounted locally in proximity to the electrodes to reduce obtrusive wiring and improve signal acquisition quality.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

Disclosed herein are vapor analyzer systems comprising a chamber defining an interior channel, an inlet in fluid communication with the interior channel, a liquid phase outlet in fluid communication with the interior channel, a vapor phase outlet in fluid communication with the interior channel, and a cooling plate disposed along at least a portion of the interior channel within the chamber. The liquid phase outlet and the inlet can define a first fluid flow path from the inlet, through the interior channel, to the liquid phase outlet. The vapor phase outlet and the inlet can define a second fluid flow path from the inlet, through the interior channel to the vapor phase outlet. Each of the first fluid flow path and the second fluid flow path can contact the cooling plate.

IPC Classes  ?

• G01N 1/40 - Concentrating samples
• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath

Abstract

An exemplary embodiment of the present disclosure provides a snake robotic device that can comprise a flexible member, one or more actuators. one or more tendons, and a controller. The flexible member can comprise a proximal end and a distal end. The one or more actuators can be configured to maneuver at least a portion of the flexible member. The one or more tendons each can comprise a first end connected to an actuator in the one or more actuators and a second end connected to a distinct portion of the flexible member, such that actuation of the one or more actuators can cause a resulting movement in the flexible member. The controller can be configured to transmit at least one control signal to the one or more actuators.

IPC Classes  ?

• B25J 18/06 - Arms flexible
• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B25J 17/00 - Joints

Abstract

Disclosed herein are a de-wetting sheets comprising a base layer having a plurality of pores. The de-wetting sheet can have a compressed state in which liquid is allowed to flow through the plurality of pores and a decompressed state in which liquid is prevented from flowing through the plurality of pores. Also disclosed herein are methods of using the same comprising compressing a de-wetting sheet layer between a wetted fibrous layer and a felt layer in which a thickness and/or a stiffness of the de-wetting sheet layer is sufficient to preserve a void volume between the wetted fibrous layer and dry felt layer. The method can further comprise decompressing the de-wetting sheet layer, the wetted fibrous layer, and the felt layer.

IPC Classes  ?

• D21F 7/12 - Drying
• B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
• B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
• B32B 15/02 - Layered products essentially comprising metal in a form other than a sheet, e.g. wire, particles
• B32B 15/18 - Layered products essentially comprising metal comprising iron or steel
• B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
• D21F 3/02 - Wet presses
• D21F 7/08 - Felts

Abstract

An engineered cementitious composite (ECC) that forms extremely durable concrete (EDC) is provide that includes Portland cement binder, a tire-derived rubber granular component (e.g., crumb rubber), a calcined clay component comprising a calcined clay, Portland cement component, and limestone, water, a superplasticizer, a polymeric or natural fiber, and optionally further including silica sand, microsilica, fly ash, a cellulose-based viscosity modifier, microsilica, or combinations thereof. Such an engineered cementitious composite has a tensile strain capacity of greater than or equal to about 3% and an ultimate tensile strength of greater than or equal to about 2.2 MPa. Such an ECC has high toughness and can be loaded in both tension and compression having a built-in capability of crack width control without the need for steel reinforcement.

IPC Classes  ?

• C04B 28/04 - Portland cements
• C04B 14/06 - QuartzSand
• C04B 14/10 - Clay
• C04B 14/28 - Carbonates of calcium
• C04B 16/06 - Macromolecular compounds fibrous
• C04B 18/08 - Flue dust
• C04B 18/22 - Rubber
• C04B 24/38 - Polysaccharides or derivatives thereof
• C04B 103/32 - Superplasticisers

Abstract

A fuel combustor for nitrogen-containing fuel minimizes NOx emissions from the combustion of nitrogen-containing fuels such as ammonia fuel. A turbine for generating power includes a drivable turbine and at least one of the fuel combustors for nitrogen-containing fuel. Methods of combusting nitrogen-containing fuel with the fuel combustor, minimizing NOx emissions formed by the combustion of nitrogen-containing fuel, and generating power are disclosed.

IPC Classes  ?

• F02C 3/22 - Gas-turbine plants characterised by the use of combustion products as the working fluid using a special fuel, oxidant, or dilution fluid to generate the combustion products the fuel or oxidant being gaseous at standard temperature and pressure
• B01D 53/94 - Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes
• F23R 3/40 - Continuous combustion chambers using liquid or gaseous fuel characterised by the use of catalytic means

Abstract

An exemplary embodiment of the present disclosure provides an extended reality (XR) system comprising an autonomous robotic device and a user interface. The autonomous robotic device can be located in a physical environment. The user interface can be configured to display an XR environment corresponding to at least a portion of the physical environment and receive an input from the user based on the user's perception in the XR environment. The autonomous robotic device can be configured to perform an autonomous action based at least in part on an input received from the user.

IPC Classes  ?

• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
• G06F 3/0346 - Pointing devices displaced or positioned by the userAccessories therefor with detection of the device orientation or free movement in a 3D space, e.g. 3D mice, 6-DOF [six degrees of freedom] pointers using gyroscopes, accelerometers or tilt-sensors
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The systems and methods can generate simulations using a stored mechanistic deterministic mathematical model based on patient specific clinical information and therapeutic data (e.g., pharmacokinetics and pharmacodynamics) to predict a patient response (e.g., cell numbers) to a given therapy. The model simulations can be used to (1) predict a leukemia response to a given treatment therapy, (2) predict patient recovery to that given treatment therapy, and/or (3) optimize treatment therapy.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection

Abstract

Systems and methods for imaging cells. Quantitative phase imaging uses variations in the index of refraction of a sample as a source of endogenous contrast, providing label-free information of sub-cellular structures and allowing for the reconstruction of valuable biophysical parameters, such as cell dry-mass at femtogram scales, mass transport, and sample thickness and fluctuations at nanometer scales. As a result, QPI has become a valuable tool in biology and medicine. However, QPI has suffered from the need for trans-illumination through relatively thin objects in order to gain access to the forward-scattered field, which carries crucial low spatial frequency information of a sample and avoid contributions from multiple scattered light or out-of-focus planes. The systems and methods can provide for reconstruction of QPI and corresponding analysis for imaging samples of cells in thick samples using an epi-illumination configuration.

IPC Classes  ?

• G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
• G01N 33/483 - Physical analysis of biological material
• G02B 21/06 - Means for illuminating specimen
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

A method for targeting epidermal delivery of an agent of interest is provided, where the method includes inserting at least one microneedle into the skin of a patient at a non-perpendicular angle, the at least one microneedle having the agent of interest. The at least one microneedle may be inserted into the skin of a patient using a system including the at least one microneedle and an angled insertion apparatus.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61B 17/20 - Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination

Abstract

An exemplary embodiment of the present disclosure provides a system for cell engineering, the system comprising an aperture and at least one sensor. The aperture can comprise a sensing zone and an electroporation zone. The at least one sensor can be disposed proximate the sensing zone. The sensor can be configured to sense an electrical property of a cell in the sensing zone and deliver electroporation energy to the cell based on the sensed electrical property of the cell.

Abstract

An exemplary embodiment of the present disclosure provides a composition for identifying a presence of tuberculosis in a subject. The composition comprises a molecule of interest configured to bind with a target molecule in a biological sample; a probe molecule configured to bind with the target molecule; and a metal particle configured to bind with the probe molecule. Another aspect of the present disclosure provides a method of diagnosing diagnosing tuberculosis in a subject. The method comprises combining the composition of the present disclosure with a sample solution comprising the biological sample to form a testing sample, imaging the testing sample, and determining, based on an image of the testing sample, whether the biological sample comprises an active tuberculosis infection.

Abstract

Lithium-ion batteries containing aluminum-based foil anode may have an ion-conducting material thereon to maintain ionic conduction between the anode and a solid-state electrolyte during charge-discharge cycling. During charge-discharge cycling, the anode changes volume, which can cause the anode to separate from the solid-state electrolyte. Said ion-conducting material is preferably deformable and maintains contact with the anode and the solid-state electrolyte through the volume changes, which may stabilize the cycling capacity and increase the useful life of the battery.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/40 - Alloys based on alkali metals
• H01M 4/46 - Alloys based on magnesium or aluminium
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0562 - Solid materials
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes

Abstract

A method of determining focal error in an additive manufacturing system comprising a laser, a recoater configured to apply a feedstock material along a build plane, and an optomechanical system configured to focus a beam generated by the laser to a focal surface proximate the build plane. The method can comprise: for each of a plurality of locations on the build plane: positioning a substrate relative to the build plane at a plurality of z-positions, each z-position corresponding to a unique distance between the build plane and the substrate; at each of the plurality of z-positions, etching a track in the substrate corresponding to the respective location in the plurality of locations on the build plane; for each etched track, determining a width of the corresponding track; and determining, based at least on the determined widths, a focal error for the respective location on the build plane.

Abstract

A system for power delivery includes an AC voltage generated at a common port connected to an electric vehicle and provides low total harmonic distortion (THD). The common port can be connected to an electric grid operating outside the vehicle and can autonomously form or follow the grid to provide advanced grid support functionality under normal and fault conditions without requiring additional power converters for real-time coordination and control outside the vehicle.

IPC Classes  ?

• B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements

Abstract

Systems and methods for guiding the generation of items based on a user preference. The system comprises a computing device comprising one or more processors, a neural network a transceiver, and at least one memory in communication with the computing device, the neural network, and the transceiver and storing computer program code. The system is configured to output a first set of items having a first attribute. The system may receive a first user input to generate, using the neural network, to generate one or more additional set of items (e.g., images) based on user preference. The system is configured to adjust and generate one or more new items until the at least one modified first attribute meets a desired preference.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

Compounds, compositions, and methods for detecting zinc in a sample. The compounds are related to zinc-sensitive fluorescence probes. The compounds provide an emission-ratiometric fluorescence response upon binding of an analyte. The compounds can be used for two-photon excitation microscopy or conventional fluorescence microscopy. The compounds can be configured to shift the emission maximum by about 10 nm to about 60 nm upon formation of a complex with Zn(II).

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/20 - Metals

Abstract

Specimen imaging systems and methods including a sample stage in a vacuum environment. The sample stage is configured to support a specimen, an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen, a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen, a mass spectrometer, and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The systems and methods can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.

IPC Classes  ?

• H01J 49/00 - Particle spectrometers or separator tubes
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes
• H01J 49/14 - Ion sourcesIon guns using particle bombardment, e.g. ionisation chambers

Abstract

An exemplary testing system and method are disclosed for mechanical testing and evaluation of geogrids and other geosynthetic materials to improve load distribution, durability, and performance. The exemplary testing apparatus and method are capable of uniaxial, biaxial, and triaxial testing on different geogrids and other geosynthetic building material, including all types of commercially available geogrids (uniaxial, biaxial, triaxial), geotextiles (woven, non-woven), as well as new-generation geogrids (including spider-web inspired that have hexagonal and other multi-scaled structures). The test apparatus can perform static (monotonic) application of load as well as cyclic tests on geosynthetic materials.

IPC Classes  ?

• G01N 3/06 - Special adaptations of indicating or recording means
• G01B 11/16 - Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge
• G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
• G06T 7/00 - Image analysis
• G06T 7/32 - Determination of transform parameters for the alignment of images, i.e. image registration using correlation-based methods

Abstract

Systems and methods for ultrasound imaging and targeting. The systems and methods can improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). The systems and methods can improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves

Abstract

A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

IPC Classes  ?

• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/38 - Animal cells
• A61L 27/56 - Porous or cellular materials
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

An exemplary embodiment provides a micro-electromechanical resonator having a positive temperature coefficient of frequency (TCP). Another embodiment provides a method of manufacturing a desired micro-electromechanical resonator, comprising: determining a desired property for the resonator over a predetermined temperature range; selecting one or more dimensions and/or one or more materials of the resonator based on the desired TCP; and providing the resonator with the one or more dimensions and/or one or more materials, in which the desired property can be one or more properties selected from the group consisting of: a temperature coefficient of frequency (TCP); a temperature turnover point; and a frequency shift.

Abstract

An acoustic system may include an array of wirelessly coupled acoustic tags, the array including a master tag configured to receive an exciter signal from a device, and at least one helper tag configured to receive the exciter signal from the device and a relayed signal from the master tag.

IPC Classes  ?

• G01S 1/72 - Beacons or beacon systems transmitting signals having a characteristic or characteristics capable of being detected by non-directional receivers and defining directions, positions, or position lines fixed relatively to the beacon transmittersReceivers co-operating therewith using ultrasonic, sonic, or infrasonic waves
• G01S 5/22 - Position of source determined by co-ordinating a plurality of position lines defined by path-difference measurements
• G01S 15/06 - Systems determining position data of a target
• G01S 15/74 - Systems using reradiation of acoustic waves, e.g. IFF, i.e. identification of friend or foe
• G01S 15/88 - Sonar systems specially adapted for specific applications
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
• H04W 4/029 - Location-based management or tracking services
• G01S 13/75 - Systems using reradiation of radio waves, e.g. secondary radar systemsAnalogous systems using transponders powered from received waves, e.g. using passive transponders
• G01S 15/87 - Combinations of sonar systems
• H04B 17/10 - MonitoringTesting of transmitters
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management
• H04W 72/0457 - Variable allocation of band or rate

Abstract

An exemplary left ventricular assist device (LVAD) and method that employs design and material designs to reduce the thrombosis risk of LVAD implant in a patient. One feature of the design includes a stented inlet member for the device that can reduce or fully eliminate a flow stasis that can trigger blood protein adsorption that can lead to chain reactions that then result in thrombosis. Other features of the design include (i) a flexible rotor and/or pump housing that can reduce blood damage, (ii) hydrophilic slippery coatings at high sheer components, such as the rotor to further reduce protein adsorption and thus thrombosis risk, (iii) magnetic-based drive and bearing components that can improve the hemocompatibility of the blood pump, and (iv) advanced controls and charging.

IPC Classes  ?

• A61M 60/117 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body for assisting the heart, e.g. transcutaneous or external ventricular assist devices

Abstract

Disclosed herein is a biochip with a plurality of endothelial cells (e.g., Schlemm's canal cells) having a plurality of pores (e.g., transcellular pores) and methods of making and using the same.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

An exemplary system and method are disclosed that is configured to evaluate by interrogation and analysis whether an incoming call from an unknown caller is a robo-call, e.g., a mass-market, spoofed, targeted, and/or evasive robocalls. The exemplary system is configured with a voice interaction model and analytical operation that can first pick up each incoming phone call on behalf of the recipient callee. The exemplary system then simulate natural conversation with the initiating caller by asking/interrogating the caller with a set of pre-stored questions that naturally occur in human conversations. The exemplary system employs the caller's responses to determine whether the call is a robocall or a natural person by assessing via pre-defined analysis for the context and/or expected natural human response.

IPC Classes  ?

• H04L 65/1076 - Screening of IP real time communications, e.g. spam over Internet telephony [SPIT]
• G10L 15/26 - Speech to text systems

Abstract

A system includes a heat-transfer conduit forming a circulating loop with a liquid metal. Heat exchangers are coupled to either end of the circulating loop to transfer heat to and from the liquid metal. A magnetohydrodynamic pump assembly is coupled to the conduit and comprising (i) an electrode configured to generate an electric current density in a first direction, (ii) a magnet configured to generate a magnetic flux density in a second direction perpendicular to the first direction. A resulting Lorentz force between the electrode and the magnet induces motion of the liquid metal in a third direction parallel to the longitudinal axis of the conduit loop. A controller is coupled to the magnetohydrodynamic pump assembly and configured to adjust an electric current applied to the electrode to vary the intensity of the electric current density, which varies a flow rate of the liquid metal.

Abstract

The present disclosure provides for methods and systems for making structures using a broad electron shower that interacts with a liquid in a high or low vacuum environment. The present disclosure provides for methods and systems for growing of high aspect ratio structures with three-dimensional topological complexity quickly by directing a liquid into an electron shower.

IPC Classes  ?

• C23C 18/14 - Decomposition by irradiation, e.g. photolysis, particle radiation
• B05B 1/02 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops
• B05B 5/16 - Arrangements for supplying liquids or other fluent material
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

An exemplary air-breathing plasma engine and methods of operation are disclosed employing an arc plasma chamber that generates plasma, e.g., electrode-coupled, direct current plasma, via electrodes continuously fed by an electrode-feeding assembly. The plasma chamber can be implemented in any one of the stages following the compression stage and having high-pressure and high-velocity air flow, e.g., for a jet engine, turbojet engine, or rocket engine.

IPC Classes  ?

• F03H 1/00 - Use of plasma to produce a reactive propulsive thrust

Abstract

An exemplary embodiment of the present disclosure provides a method of converting formate to a desired compound. The method comprises providing a biocatalyst and formate to form a reaction mixture and reacting at least the biocatalyst with formate to produce a first reaction product.

IPC Classes  ?

• C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
• C12N 9/10 - Transferases (2.)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12P 7/40 - Preparation of oxygen-containing organic compounds containing a carboxyl group
• C12P 13/06 - AlanineLeucineIsoleucineSerineHomoserine

Abstract

Exemplary geosynthetic apparatus, e.g., geogrid, and designs thereof are disclosed that are configured to restrict displacement of aggregate that mimics biostructures that optimized aperture size, aperture shape and aperture orientation to improve load distribution, improve durability, and/or improve performance in retaining aggregates and other geo materials. The exemplary geosynthetic apparatus as a product is configured as a unit cell in which the center of the unit cell has a primary structure that extend through the center to the edge of the unit cell or one or more intermediate radial position (also referred to as “radial transect boundaries”) therebetween. In embodiments in which the primary structure extends to the transect boundaries through the center of the unit cell, the primary structure are referred to as “radial ribs.”

IPC Classes  ?

• E02D 17/20 - Securing of slopes or inclines

Abstract

An exemplary embodiment of the present disclosure provides a system for detecting biomarkers. The system can comprise a composition a first electrode, a second electrode, and an electrical property sensor in electrical communication with the first electrode and the second electrode. The electrical property sensor can be configured to measure an electrical property of the composition. The composition can comprise a molecule of interest configured to bind with a target molecule in a biological sample, a probe molecule configured to bind with the target molecule, and a first metal particle configured to bind with the probe molecule.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Exemplary air breathing plasma jet engine and method of operation that can be used in electrically powered aircraft and spacecraft as a hybrid between a turbo jet engine and a ramjet or supersonic sonic ramjet (SCRAMJET) engine. The air breathing plasma jet engine includes a compression stage that is configured to compress and slow down incoming air. The compressor can be driven by a high RPM electric motor. The compression stage generates compressed and heated air flow that is passed to a plasma chamber that is configured to add heat to the compressed and heated air flow. The heat are converted to an impulse, e.g., using a converging-diverging (De Laval) nozzle. The system is beneficially configured to reuse the heat byproduct generated in the compression stage.

IPC Classes  ?

• F03H 1/00 - Use of plasma to produce a reactive propulsive thrust
• B64G 1/40 - Arrangements or adaptations of propulsion systems

Abstract

A computer-implemented method for predicting risk of ischemia in anomalous aortic origin of a coronary artery (AAOCA) includes receiving medical imaging data of a patient. The method includes extracting, from the medical imaging data, patient-specific morphological imaging biomarkers pertaining to AAOCA and incorporating the biomarkers into a computer model. The method includes simulating, using the computer model, hemodynamics of the patient under simulated stress conditions and a combination of variables, the variables comprising physiological properties of the patient. The method also includes predicting and outputting a patient-specific risk profile of ischemia and/or sudden cardiac death based on simulated hemodynamics.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A centralizer device includes a body collar and a tail collar each extending circumferentially around a central axis to define a longitudinal channel. The central axis extends from an up-hole direction towards a downhole direction of the centralizer device. The centralizer device includes a body extending between the body collar and the tail collar. The body includes a first portion, a second portion, and a bow portion that extends radially outward from the central axis to define at least one apex. The body further defines at least one opening. The centralizer device may include a tail extending (i) longitudinally from the tail collar or the body collar and (ii) radially outward from the central axis, the tail comprising a tail tip at a distal end thereof.

IPC Classes  ?

• E21B 17/10 - Wear protectorsCentralising devices

Abstract

The present disclosure relates to nanoparticle compositions for modifying antigen-specific T cells and uses thereof.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61K 39/21 - Retroviridae, e.g. equine infectious anemia virus
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

Disclosed herein are esophageal sleeve devices comprising bioresorbable scaffolds having a first shape and a second shape. The bioresorbable scaffolds can be made from a shape memory polymer comprising at least one monomer unit of glycerol and at least one monomer unit of dodecanedioate. The bioresorbable scaffolds can also have a functionalized surface modified to have a biology corresponding to a patient. The bioresorbable scaffolds can take the first shape at a first environmental temperature and the second shape at a second environmental temperature. the second environmental temperature being greater than the first environmental temperature. Also disclosed herein are methods of implanting the same.

IPC Classes  ?

• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

An exemplary embodiment of the present disclosure provides a biometric identification system, comprising one or more sensors and a controller. The one or more sensors can be configured to generate data corresponding to sounds generated by the heartbeat of a user. The controller can be configured to receive the data and authenticate the user based, at least in part, on the data.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate
• B81B 7/02 - Microstructural systems containing distinct electrical or optical devices of particular relevance for their function, e.g. microelectro-mechanical systems [MEMS]
• H04R 1/04 - Structural association of microphone with electric circuitry therefor
• H04R 1/46 - Special adaptations for use as contact microphones, e.g. on musical instrument, on stethoscope
• H04R 19/04 - Microphones
• G06N 5/00 - Computing arrangements using knowledge-based models

Abstract

Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61Q 19/00 - Preparations for care of the skin

Abstract

A computer-implemented method for predicting risk of ischemia in anomalous aortic origin of a coronary artery (AAOCA) includes receiving medical imaging data of a patient. The method includes extracting, from the medical imaging data, patient-specific morphological imaging biomarkers pertaining to AAOCA and incorporating the biomarkers into a computer model. The method includes simulating, using the computer model, hemodynamics of the patient under simulated stress conditions and a combination of variables, the variables comprising physiological properties of the patient. The method also includes predicting and outputting a patient-specific risk profile of ischemia and/or sudden cardiac death based on simulated hemodynamics.

Abstract

An exemplary system and method for a head-worn device for augmenting speech therapy or mitigating Parkinson's effect or other speech-impairing conditions by providing haptic feedback, vibratory feedback, audio feedback, or other stimulations to a wearer by isolating and analyzing vocal/speech output of the user for signal-associated assessment, including, e.g., based on timing, direction, loudness, and/or speaking rate. The haptic biofeedback and/or acoustic/vibratory feedback are beneficially provided to the wearer when (i) certain minimum threshold targets, e.g., relating to the user's loudness or speech rate are not met or (ii) when certain thresholds are exceeded, e.g., for loudness, intensity, or speech rate. The system and method can additionally isolate a detected speech or sound and determine if it is from the user. As a signal-assessment analysis system and method, the implementation can be performed with minimal computation power or resources, e.g., as compared to speech or voice recognition technology.

IPC Classes  ?

• G10L 15/08 - Speech classification or search
• G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
• G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog