An optical microendoscopy includes an endoscopic probe that has a plurality of integrated fiber optics for uniform illumination and an array of gradient index (GRIN) lenses. The GRIN lenses are configured to capture a reflected light field from one or more on-axis sampling of the reflected light field and two or more off-axis sampling of the reflected light field
A61B 1/07 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement utilisant des moyens conduisant la lumière, p. ex. des fibres optiques
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
Disclosed herein is a synthetic memory system, comprising: a recombinase; a modified transcription factor; and a first nucleic acid comprising a first attachment site, a second attachment site, and a target gene between said first attachment site and said second attachment site; wherein at least one of the first attachment site and the second attachment site comprises a modified DNA operator to which the modified transcription factor can reversibly bind; and wherein, when the modified transcription factor is bound to the modified DNA operator, the recombinase is blocked from binding to the attachment site comprising said modified DNA operator.
In a joint movement device for selective flexion and extension of a joint, a tendon is disposed adjacent to the first and second joint members. A tendon securing device is secured to the second joint member, the tendon being secured to the tendon securing device. At least one phalange ring is secured to a joint member and includes a tending routing mechanism configured to route the tendon through the phalange ring. An actuator is coupled to the tendon and pulls the tendon inwardly to cause the joint to flex. An elastic member is coupled to the phalange ring and tendon securing device and applies an extension force thereto, thereby causing the joint to extend when the actuator releases the tendon.
An exemplary embodiment of the present disclosure provides a method of sensing at least one characteristic of an analyte comprising: flowing media with the analyte through one or more microcavities; energizing the microcavity; and sensing at least one of the characteristics of the analyte via interrogation of the energized microcavity. Each of the one or more microcavities can comprise: a first mirror on a first planar surface; a second mirror on a second planar surface opposing the first planar surface; and at least one spacer between the first and second mirrors. The first mirror, second mirror, and at least one spacer can define a channel having an inlet and an outlet. The first and second mirrors can be positioned between the inlet and outlet.
Delivery of oligonucleotides and other agents to tumor microenvironments is challenging due to their rapid clearance, nuclease susceptibility, and inability to traverse plasma membranes, impeding their effective use for the treatment of a variety of disorders. Disclosed herein is a self-agglomerating nanohydrogel and methods of delivering an agent as well as methods of treating cancer with the nanohydrogel.
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
6.
UNIFIED MACHINE LEARNING FRAMEWORK TO EMULATE DENSITY FUNCTIONAL THEORY SIMULATIONS
A method comprising providing a training data set to a machine learning (ML) system, the training data set indicative of density functional theory (DFT) data for a plurality of materials, the DFT data representing atomic configurations for the plurality of materials, determining a fingerprint for the atomic configuration for each of the plurality of materials, inputting the fingerprints into a machine learning system, generating, with the machine learning system, electron charge density data for the plurality of materials, inputting the electron charge density data and the fingerprint into a machine learning system, and predicting, with the machine learning system, one or more DFT properties of the plurality of materials.
A method for treating a neuropsychiatric or neurological disorder by inducing neurological response in a subject, the method comprising: selecting a frequency for application of non-invasive brain stimulation to which a subject is to be exposed; exposing the subject to the non-invasive sensory stimulation at the selected frequency in a range of about 5-100 Hz.
A61M 21/00 - Autres dispositifs ou méthodes pour amener un changement dans l'état de conscienceDispositifs pour provoquer ou arrêter le sommeil par des moyens mécaniques, optiques ou acoustiques, p. ex. pour mettre en état d'hypnose
8.
REDISTRIBUTION LAYER EMBEDDED MAGNETIC CORE INDUCTOR
A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.
A coupon sampler for a reactor system includes a lower assembly having an in-line portion configured to receive a flow of a molten salt, and a lower assembly pipe portion extending transverse from the in-line portion and defining a lower channel therethrough. The coupon sampler further includes an upper assembly fluidically coupled with the lower assembly. The upper assembly includes an upper assembly pipe portion defining an upper channel therethrough and cooperating with the lower channel to define a sampling channel of the coupon sampler. The coupon sampler further includes a coupon device disposed fully within the sampling channel. The coupon sampler further includes an actuation mechanism operatively coupled with the coupon device and configured to move the coupon device axially into and out of the flow of the molten salt.
G01N 1/14 - Dispositifs d'aspiration, p. ex. pompesDispositifs d'éjection
G21C 17/022 - Dispositifs ou dispositions pour la surveillance du réfrigérant ou du modérateur pour la surveillance de réfrigérants ou de modérateurs liquides
G21C 17/06 - Dispositifs ou dispositions pour la surveillance ou le test du combustible ou des éléments combustibles en dehors du cœur du réacteur, p. ex. pour la consommation ou pour la contamination
11.
System and Methods for Predicting Polymer Properties
A method for predicting polymer properties that can include converting chemical fragments from a plurality of first polymers into standardized data strings, separating each of the standardized data strings into one or more tokens, predicting, via a first machine learning algorithm, one or more tokens from each of the standardized data strings, computing, via a processor device, one or more unique fingerprints for each of the standardized data strings, and mapping, via a second machine learning algorithm, one or more properties of the plurality of first polymers and one or more properties of a plurality of second polymers to the one or more unique fingerprints.
A structured adsorbent assembly is described, which is usefully employed for pressure swing adsorption (PSA) processing of ambient air to generate high purity oxygen. The structured adsorbent assembly in various implementations may include cellulosic carbon molecular sieve fibers formed by spinning of precursor cellulose followed by pyrolysis of the spun fibers, as an argon-selective adsorbent, or AgX zeolite contained on and/or in polymeric fibers, as an argon-selective adsorbent, and such argon-selective adsorbents may be in combination with nitrogen-selective adsorbent such as LiX zeolite contained on and/or in polymeric fibers. The structured adsorbent assembly may be employed in PSA systems and processes to achieve highly efficient and economic generation of high purity oxygen for applications such as distributed gasification power generation.
B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone libreCompositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
A coupon sampler for a reactor system includes a lower assembly having an in-line portion configured to receive a flow of a molten salt, and a lower assembly pipe portion extending transverse from the in-line portion and defining a lower channel therethrough. The coupon sampler further includes an upper assembly fluidically coupled with the lower assembly. The upper assembly includes an upper assembly pipe portion defining an upper channel therethrough and cooperating with the lower channel to define a sampling channel of the coupon sampler. The coupon sampler further includes a coupon device disposed fully within the sampling channel. The coupon sampler further includes an actuation mechanism operatively coupled with the coupon device and configured to move the coupon device axially into and out of the flow of the molten salt.
G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant
G21C 3/18 - Entretoises intérieures ou autre matériau non actif à l'intérieur de l'enveloppe, p. ex. pour compenser l'expansion des barres combustibles ou pour compenser une réactivité excessive
G21C 3/54 - Sels fondus, compositions oxydes ou hydroxydes
G21C 17/017 - Inspection ou maintenance de tuyaux ou de tubes dans des installations nucléaires
14.
WIRELESS BATTERYLESS SOFT SENSORS FOR AMBULATORY CARDIOVASCULAR HEALTH MONITORING
An exemplary embodiment of the present disclosure provides a cardiovascular sensing system, comprising a sensor, an external antenna, and a controller. The sensor can be configured to be worn by a user. The sensor can comprise an inductive capacitive (LC) circuit. The sensor can be configured to deform in response to a strain induced by vibrations of the heart of the user. The external antenna can be inductively coupled to the sensor. The external antenna can be configured to receive a signal from the LC circuit. The controller can be configured to determine a seismocardiogram (SCG) of the user based, at least in part, on the signal received by the LC circuit.
An exemplary system and method for enhanced structural and thermal structure having an engineered thermal transition zone that integrates with an energy pile section having foundation pile for retaining engineered material or soil and thermal cooling loop that circulate through the material. An apparatus includes an outer surface extending between a first end and a second end of the section; an inner surface spaced apart and radially inward from the outer surface and defining a central channel of the apparatus; a thermal transition zone extending between the outer surface and the inner surface, the thermal transition zone configured to facilitate heat transfer between the inner surface and the outer surface; and a conductive conduit extending through at least the thermal transition zone from the first end to the second end of the apparatus.
E02D 31/00 - Dispositions de protection pour les fondations ou ouvrages réalisés par des techniques de fondationMesures dans le cadre des techniques de fondation pour protéger le sol ou l'eau du sous-sol, p. ex. prévention ou neutralisation de la pollution par le pétrole
An exemplary embodiment of the present disclosure provides a method of characterizing a plurality of cells, comprising: providing a sample comprising the plurality of cells; obtaining a plurality of images of the plurality of cells, each image taken at a different point in time, each image comprising a plurality of pixels, each pixel represented by an image value; and characterizing the plurality of cells based, at least in part, on the image values.
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
The present disclosure relates to systems and methods for nucleic acid storage that can be used under ambient conditions economically. In one implementation, the system may include a cartridge. The cartridge may include a first surface and a second surface opposing the first surface. The cartridge may include a chamber disposed (i) parallel to the first surface and the second surface and (ii) between the first surface and the second surface. The chamber may be configured to receive a blotter substrate. The cartridge may also include at least one opening disposed in the first surface above and interfaces with the chamber. The opening may be configured to receive a permeable membrane.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
B01D 15/20 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement de la matière adsorbante ou absorbante
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01L 9/00 - Dispositifs de supportDispositifs de serrage
18.
CONTROL OF INERTIAL-LESS HIGH-FREQUENCY ISOLATED CONVERTERS
Systems and methods for controlling power converter system. The system comprises a DC bridge electrically coupled to a DC power source. The system further comprises an AC bridge. The system further comprises a transformer comprising a primary winding interfacing with the DC bridge and a secondary winding interfacing with the AC bridge. The system also comprises a controller configured to control the AC and DC bridges to convert a DC voltage from the DC power source to an AC voltage at an output of the AC bridge. The controller is configured to control the DC bridge to provide an input voltage to the primary winding of the transformer. The input voltage comprises a positive voltage portion and a negative voltage portion. The controller causes the AC bridge to flip a polarity of the output.
H02M 7/217 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant continu sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
19.
MODULAR MULTILEVEL INERTIAL-LESS MV TO DC (MV2DC) TRANSFORMERS
A power converter, comprising a DC bridge, a first transformer, a plurality of AC bridges, and a controller. The DC bridge can be electrically coupled to a DC power source. The first transformer can comprise a primary winding electrically interfacing with the DC bridge and a plurality of secondary windings. The plurality of AC bridges can be electrically coupled in series, wherein each of the plurality of AC bridges electrically interfaces with a respective secondary winding of the plurality of secondary windings. The controller can be configured to control the DC bridge and the plurality of AC bridges to convert DC power from the DC power source having a voltage level at a first magnitude to DC or AC power having a voltage level at a second magnitude greater than the first magnitude at an output of the plurality of AC bridges.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 7/5387 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur dans une configuration en pont
H02M 1/10 - Dispositions comprenant des moyens de conversion, pour permettre l'alimentation à volonté d'une charge par des sources de puissance de nature différente, p. ex. à courant alternatif ou à courant continu
H02J 3/36 - Dispositions pour le transfert de puissance électrique entre réseaux à courant alternatif par l'intermédiaire de haute tension à courant continu
20.
REFRIGERATION SYSTEM USING THERMALLY RESPONSIVE LIQUIDS
Systems and methods for cooling air with an air conditioning. The system comprises a first thermally responsive liquid having a first lower critical solution temperature (LCST) configured to be separated into a first water-scarce phase liquid and a first water-rich phase upon liquid heating. The system further comprises a first heater configured to heat the first thermally responsive liquid to a temperature that is at least the first LCST to separate the first thermally responsive liquid into the first water-scarce phase liquid and the first water-rich phase liquid. The system may also comprise a closed loop air system configured to circulate air. The first water-scarce phase liquid may be configured to absorb moisture from the air and the first water-rich phase liquid may be configured to desorb water into the air to cause cooling through evaporative cooling.
F24F 3/14 - Systèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par humidificationSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par déshumidification
F24F 5/00 - Systèmes ou appareils de conditionnement d'air non couverts par ou
F24F 12/00 - Utilisation de systèmes à récupération d'énergie dans le conditionnement de l'air, la ventilation ou la formation d'écrans d'air
21.
TAILORED VARYING GEOMETRY HEAT EXCHANGERS ENABLED BY ADDITIVE MANUFACTURING TO ADDRESS AND EXPLOIT CHANGING HEAT TRANSFER PHENOMENA DURING PHASE CHANGE
An exemplary embodiment of the present disclosure provides a heat exchanger comprising a chamber and a channel system located within the chamber. The channel system can comprise a repeating set of a first end, a second end, and a plurality of channels between the first end and the second end. A physical property of the plurality of channels can vary from the first end to the second end. A plurality of distribution manifolds can redirect at least a portion of the liquid phase of the first fluid to a plurality of bypass channels. The first fluid can flow through the plurality of channels, and the second fluid can flow through the chamber external to the plurality of channels, which can result in a transfer of heat.
F28D 7/16 - Appareils échangeurs de chaleur comportant des ensembles de canalisations tubulaires fixes pour les deux sources de potentiel calorifique, ces sources étant en contact chacune avec un côté de la paroi d'une canalisation les canalisations étant espacées parallèlement
B33Y 80/00 - Produits obtenus par fabrication additive
22.
Super-Resolution Microscope for 3D cell and Tissue Imaging
A multifocal scanning microscopy (MSM) for super-resolution imaging was developed with multicolor acquisition and minimal instrumental complexity. MSM implements a stationary, interposed multi-focal multicolor excitation by exploiting the motion of the specimens, realizing super-resolution microscopy through a general epi-fluorescence platform without compromising the image-scanning mechanism or inducing complex instrument alignment. The system is demonstrated with various phantom and biological specimens, and the results present effective resolution doubling, optical sectioning, and contrast enhancement. MSM, as a highly accessible and compatible super-resolution technique, may offer a promising methodological pathway for broad cell biological discoveries.
H04N 23/951 - Systèmes de photographie numérique, p. ex. systèmes d'imagerie par champ lumineux en utilisant plusieurs images pour influencer la résolution, la fréquence d'images ou le rapport de cadre
Toyota Motor Engineering & Manufacturing North America, Inc. (USA)
Georgia Tech Research Corporation (USA)
Inventeur(s)
Song, Yuyang
Tanaka, Masato
Li, Mingzhe
Qi, Hang
Abrégé
A body can be configured to be selectively morphable. One or more body support members can be operatively connected to an outer surface of the body. The one or more body support members can be arranged in a pattern to define at least one morphing region. A contracting member (e.g., a shape memory polymer) can be operatively connected to the outer surface of the body. When activated, the contracting member can contract, which can cause the body to morph (e.g., bend) from a non-activated configuration into an activated configuration.
A light-field microscopy system includes a light-field microscope, and an image processing system configured to receive images from the light-field microscope and perform a hybrid point-spread function (PSF) operation using a hybrid point-spread function that comprises numerical profiles that are adjusted by experimental positions acquired from an experimentally recorded PSF.
Systems and methods for locking an external sheath in place. The system comprises a steerable stylet. The system further comprises an external sheath configured to removably house at least a portion of the steerable stylet. The system also comprises at least one steerable stylet controller configured to control the movement of the steerable stylet and the external sheath in at least one dimension.
Exemplary engineered synthetic genetic constructs are disclosed that can induce high levels of gene expression in response to changes in metabolism that are unique to solid tumors. These synthetic genetic constructs, hereafter referred to as promoters, can function in human cells, and can be used to specify or enhance the activity of chimeric antigen receptor (CAR) T cell therapies. CAR-T cell therapies are an important class of immunotherapies that is predicted to grow to be a 15B market by 2028 in the US. CAR-T cells and other autologous immune cell therapies have been shown to be deactivated by adenosine, an immunosuppressive small metabolite that accumulates to high levels in solid tumors. Accumulation of adenosine (e.g., ribonucleoside adenosine) can trigger a CREB-mediated signaling pathway to suppress the function of immune cells in solid tumor environments.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
27.
SHAPE MEMORY BASED DYNAMIC SEAL TO PREVENT LEAKAGE IN HEART VALVES
A dynamic seal for a biological vessel, comprising an inner frame and a shape memory layer. The inner frame can have an annular shape and can comprise an outer surface. The shape¬ memory layer can be disposed around an outer surface of the inner frame. The shape-memory layer can be configured to transition between a compressed state and an expanded state. The dynamic seal can be configured to be inserted into a vessel, such that when the shape-memory layer is in the compressed state, at least one gap is present between the shape-memory layer and an inner wall of the vessel, and the shape-memory layer is configured to transition to the expanded state to fill the at least one gap.
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (USA)
Inventeur(s)
Bui, Hieu
Gangwish, Justin
Khair, Nipa
Forleo, Marcio
Joshi, Srujana
James, Susan
Dasi, Lakshmi Prasad
Abrégé
An adaptive seal includes an attachment configured to attach to a replacement heart valve to close gaps between the replacement heart valve and a patient's own and surrounding structure to reduce or to prevent paravalvular leakages.
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration/exfiltration) in a processing pipeline.
G01J 5/00 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique
G01J 5/10 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant des détecteurs électriques de radiations
G05D 1/689 - Interaction avec des charges utiles ou des entités externes dirigeant des charges utiles vers des cibles fixes ou en mouvement
G05D 105/80 - Applications spécifiques des véhicules commandés pour la collecte d’informations, p. ex. recherche universitaire
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
Disclosed herein are hydrogel structures and methods of making and use thereof. For example, disclosed herein are methods of making a device comprising a hydrogel matrix and a first chamber in the hydrogel matrix, the hydrogel matrix being derived from a prepolymer and the first chamber being perfusable. The methods can, for example, comprise blocking a first portion of a pre-polymerization solution with a first photomask, the pi-polymerization solution comprising the prepolymer, such that the pre-polymerization solution comprises an exposed portion and a first blocked portion. The methods can further comprise irradiating the exposed portion of the pi-polymerization solution and the first photomask with electromagnetic radiation, the first photomask being substantially opaque to the electromagnetic radiation. In some examples, the prepolymer within the exposed portion of pre-polymerization solution photopolymerizes to form the hydrogel matrix and the prepolymer within the first blocked portion does not photopolymerize and forms the first chamber.
Disclosed herein natural gas power generating systems comprising a post-combustion carbon capture (PCC) unit configured to remove carbon dioxide from a waste gas to create a flue gas, a direct air capture (DAC) unit configured to adsorb carbon dioxide from an atmospheric gas, and a compression unit configured to receive at least one of: (i) carbon dioxide gas from the first carbon dioxide rich outlet line and (ii) carbon dioxide gas from the second carbon dioxide rich outlet line to create a compressed carbon dioxide product. The DAC unit can further generate steam using a heat exchange with steam generated by a HRSG. The DAC unit can further comprise a sorbent module containing the sorbent bed. The sorbent module can have a carbon capture state configured to adsorb carbon dioxide and a regeneration state configured to contact steam with the sorbent bed.
In an embodiment, metal-organic nanowires or nanofibers comprising polymer chains with around 100 or more repeat units are synthesized. The metal-organic nanowires or nanofibers are exposed to a reactive gas at a temperature in excess of around 100° C. and at a pressure in the range from around 0.001 to around 100 atmospheres.
D06M 11/34 - Traitement des fibres, fils, filés, tissus ou des articles fibreux faits de ces matières, avec des substances inorganiques ou leurs complexesUn tel traitement combiné avec un traitement mécanique, p. ex. mercerisage avec de l'oxygène, de l'ozone, des ozonides, des oxydes, des hydroxydes ou des percomposésSels dérivés d'anions avec une liaison élément amphotère-oxygène avec de l'oxygène, de l'ozone ou des ozonides
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
Disclosed herein are vapor analyzer systems comprising a chamber defining an interior channel, an inlet in fluid communication with the interior channel, a liquid phase outlet in fluid communication with the interior channel, a vapor phase outlet in fluid communication with the interior channel, and a cooling plate disposed along at least a portion of the interior channel within the chamber. The liquid phase outlet and the inlet can define a first fluid flow path from the inlet, through the interior channel, to the liquid phase outlet. The vapor phase outlet and the inlet can define a second fluid flow path from the inlet, through the interior channel to the vapor phase outlet. Each of the first fluid flow path and the second fluid flow path can contact the cooling plate.
An exemplary embodiment of the present disclosure provides a snake robotic device that can comprise a flexible member, one or more actuators. one or more tendons, and a controller. The flexible member can comprise a proximal end and a distal end. The one or more actuators can be configured to maneuver at least a portion of the flexible member. The one or more tendons each can comprise a first end connected to an actuator in the one or more actuators and a second end connected to a distinct portion of the flexible member, such that actuation of the one or more actuators can cause a resulting movement in the flexible member. The controller can be configured to transmit at least one control signal to the one or more actuators.
Disclosed herein are a de-wetting sheets comprising a base layer having a plurality of pores. The de-wetting sheet can have a compressed state in which liquid is allowed to flow through the plurality of pores and a decompressed state in which liquid is prevented from flowing through the plurality of pores. Also disclosed herein are methods of using the same comprising compressing a de-wetting sheet layer between a wetted fibrous layer and a felt layer in which a thickness and/or a stiffness of the de-wetting sheet layer is sufficient to preserve a void volume between the wetted fibrous layer and dry felt layer. The method can further comprise decompressing the de-wetting sheet layer, the wetted fibrous layer, and the felt layer.
B32B 5/02 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments
B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
B32B 15/02 - Produits stratifiés composés essentiellement de métal autrement que sous forme de feuille, p. ex. en fils, en parcelles
B32B 15/18 - Produits stratifiés composés essentiellement de métal comportant du fer ou de l'acier
B32B 27/12 - Produits stratifiés composés essentiellement de résine synthétique adjacente à une couche fibreuse ou filamenteuse
An engineered cementitious composite (ECC) that forms extremely durable concrete (EDC) is provide that includes Portland cement binder, a tire-derived rubber granular component (e.g., crumb rubber), a calcined clay component comprising a calcined clay, Portland cement component, and limestone, water, a superplasticizer, a polymeric or natural fiber, and optionally further including silica sand, microsilica, fly ash, a cellulose-based viscosity modifier, microsilica, or combinations thereof. Such an engineered cementitious composite has a tensile strain capacity of greater than or equal to about 3% and an ultimate tensile strength of greater than or equal to about 2.2 MPa. Such an ECC has high toughness and can be loaded in both tension and compression having a built-in capability of crack width control without the need for steel reinforcement.
A fuel combustor for nitrogen-containing fuel minimizes NOx emissions from the combustion of nitrogen-containing fuels such as ammonia fuel. A turbine for generating power includes a drivable turbine and at least one of the fuel combustors for nitrogen-containing fuel. Methods of combusting nitrogen-containing fuel with the fuel combustor, minimizing NOx emissions formed by the combustion of nitrogen-containing fuel, and generating power are disclosed.
F02C 3/22 - Ensembles fonctionnels de turbines à gaz caractérisés par l'utilisation de produits de combustion comme fluide de travail utilisant un combustible, un oxydant ou un fluide de dilution particulier pour produire les produits de combustion le combustible ou l'oxydant étant gazeux aux température et pression normales
B01D 53/94 - Épuration chimique ou biologique des gaz résiduaires des gaz d'échappement des moteurs à combustion par des procédés catalytiques
F23R 3/40 - Chambres de combustion à combustion continue utilisant des combustibles liquides ou gazeux caractérisées par l'emploi de moyens catalytiques
38.
WIRELESS SOFT SCALP ELECTRONICS AND VIRTUAL REALITY SYSTEM FOR BRAIN-MACHINE INTERFACES
An exemplary wireless soft scalp electronic system and method are disclosed that can actuate commands for a brain-machine interface (BMI) or brain-computer-interface (BCI) by performing real-time, continuous classification, e.g., via a trained neural network, of motor imagery (MI) brain signals or of steady-state visually evoked potential (SSVEP) signals. In some embodiments, the exemplary system is configured as a low-profile, portable system that includes microneedle electrodes that can acquire EEG signals for a brain-machine interface controller. The microneedle electrodes may be configured as soft imperceptible gel-less epidermis-penetrating microneedle electrodes that can provide improved contact surface area and reduced electrode impedance density, e.g., to enhance EEG signals and the signal classification accuracy. The microneedle electrodes can be further integrated with soft electronics that can be mounted locally in proximity to the electrodes to reduce obtrusive wiring and improve signal acquisition quality.
An exemplary embodiment of the present disclosure provides an extended reality (XR) system comprising an autonomous robotic device and a user interface. The autonomous robotic device can be located in a physical environment. The user interface can be configured to display an XR environment corresponding to at least a portion of the physical environment and receive an input from the user based on the user's perception in the XR environment. The autonomous robotic device can be configured to perform an autonomous action based at least in part on an input received from the user.
G05B 19/4155 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par le déroulement du programme, c.-à-d. le déroulement d'un programme de pièce ou le déroulement d'une fonction machine, p. ex. choix d'un programme
G06F 3/0346 - Dispositifs de pointage déplacés ou positionnés par l'utilisateurLeurs accessoires avec détection de l’orientation ou du mouvement libre du dispositif dans un espace en trois dimensions [3D], p. ex. souris 3D, dispositifs de pointage à six degrés de liberté [6-DOF] utilisant des capteurs gyroscopiques, accéléromètres ou d’inclinaison
The systems and methods can generate simulations using a stored mechanistic deterministic mathematical model based on patient specific clinical information and therapeutic data (e.g., pharmacokinetics and pharmacodynamics) to predict a patient response (e.g., cell numbers) to a given therapy. The model simulations can be used to (1) predict a leukemia response to a given treatment therapy, (2) predict patient recovery to that given treatment therapy, and/or (3) optimize treatment therapy.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
Systems and methods for imaging cells. Quantitative phase imaging uses variations in the index of refraction of a sample as a source of endogenous contrast, providing label-free information of sub-cellular structures and allowing for the reconstruction of valuable biophysical parameters, such as cell dry-mass at femtogram scales, mass transport, and sample thickness and fluctuations at nanometer scales. As a result, QPI has become a valuable tool in biology and medicine. However, QPI has suffered from the need for trans-illumination through relatively thin objects in order to gain access to the forward-scattered field, which carries crucial low spatial frequency information of a sample and avoid contributions from multiple scattered light or out-of-focus planes. The systems and methods can provide for reconstruction of QPI and corresponding analysis for imaging samples of cells in thick samples using an epi-illumination configuration.
A method for targeting epidermal delivery of an agent of interest is provided, where the method includes inserting at least one microneedle into the skin of a patient at a non-perpendicular angle, the at least one microneedle having the agent of interest. The at least one microneedle may be inserted into the skin of a patient using a system including the at least one microneedle and an angled insertion apparatus.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 17/20 - Instruments, dispositifs ou procédés chirurgicaux pour la vaccination ou le nettoyage de la peau avant la vaccination
43.
TARGETED FEEDBACK-CONTROLLED HIGH EFFICIENCY SINGLE CELL ELECTROPORATION FOR GENE AND CELL THERAPY
An exemplary embodiment of the present disclosure provides a system for cell engineering, the system comprising an aperture and at least one sensor. The aperture can comprise a sensing zone and an electroporation zone. The at least one sensor can be disposed proximate the sensing zone. The sensor can be configured to sense an electrical property of a cell in the sensing zone and deliver electroporation energy to the cell based on the sensed electrical property of the cell.
44.
SYSTEMS AND METHODS FOR DIAGNOSIS OF TUBERCULOSIS AND OTHER INFECTIONS
An exemplary embodiment of the present disclosure provides a composition for identifying a presence of tuberculosis in a subject. The composition comprises a molecule of interest configured to bind with a target molecule in a biological sample; a probe molecule configured to bind with the target molecule; and a metal particle configured to bind with the probe molecule. Another aspect of the present disclosure provides a method of diagnosing diagnosing tuberculosis in a subject. The method comprises combining the composition of the present disclosure with a sample solution comprising the biological sample to form a testing sample, imaging the testing sample, and determining, based on an image of the testing sample, whether the biological sample comprises an active tuberculosis infection.
45.
SOLID-STATE BATTERIES INCLUDING AN ION-CONDUCTING MATERIAL BETWEEN AN ANODE AND A SOLID-STATE ELECTROLYTE
Lithium-ion batteries containing aluminum-based foil anode may have an ion-conducting material thereon to maintain ionic conduction between the anode and a solid-state electrolyte during charge-discharge cycling. During charge-discharge cycling, the anode changes volume, which can cause the anode to separate from the solid-state electrolyte. Said ion-conducting material is preferably deformable and maintains contact with the anode and the solid-state electrolyte through the volume changes, which may stabilize the cycling capacity and increase the useful life of the battery.
H01M 4/46 - Alliages à base de magnésium ou d'aluminium
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
A method of determining focal error in an additive manufacturing system comprising a laser, a recoater configured to apply a feedstock material along a build plane, and an optomechanical system configured to focus a beam generated by the laser to a focal surface proximate the build plane. The method can comprise: for each of a plurality of locations on the build plane: positioning a substrate relative to the build plane at a plurality of z-positions, each z-position corresponding to a unique distance between the build plane and the substrate; at each of the plurality of z-positions, etching a track in the substrate corresponding to the respective location in the plurality of locations on the build plane; for each etched track, determining a width of the corresponding track; and determining, based at least on the determined widths, a focal error for the respective location on the build plane.
47.
SYSTEMS AND METHODS FOR USING ELECTRIC VEHICLES AS AN ENERGY HUB
A system for power delivery includes an AC voltage generated at a common port connected to an electric vehicle and provides low total harmonic distortion (THD). The common port can be connected to an electric grid operating outside the vehicle and can autonomously form or follow the grid to provide advanced grid support functionality under normal and fault conditions without requiring additional power converters for real-time coordination and control outside the vehicle.
Systems and methods for guiding the generation of items based on a user preference. The system comprises a computing device comprising one or more processors, a neural network a transceiver, and at least one memory in communication with the computing device, the neural network, and the transceiver and storing computer program code. The system is configured to output a first set of items having a first attribute. The system may receive a first user input to generate, using the neural network, to generate one or more additional set of items (e.g., images) based on user preference. The system is configured to adjust and generate one or more new items until the at least one modified first attribute meets a desired preference.
Compounds, compositions, and methods for detecting zinc in a sample. The compounds are related to zinc-sensitive fluorescence probes. The compounds provide an emission-ratiometric fluorescence response upon binding of an analyte. The compounds can be used for two-photon excitation microscopy or conventional fluorescence microscopy. The compounds can be configured to shift the emission maximum by about 10 nm to about 60 nm upon formation of a complex with Zn(II).
Specimen imaging systems and methods including a sample stage in a vacuum environment. The sample stage is configured to support a specimen, an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen, a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen, a mass spectrometer, and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The systems and methods can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.
An exemplary testing system and method are disclosed for mechanical testing and evaluation of geogrids and other geosynthetic materials to improve load distribution, durability, and performance. The exemplary testing apparatus and method are capable of uniaxial, biaxial, and triaxial testing on different geogrids and other geosynthetic building material, including all types of commercially available geogrids (uniaxial, biaxial, triaxial), geotextiles (woven, non-woven), as well as new-generation geogrids (including spider-web inspired that have hexagonal and other multi-scaled structures). The test apparatus can perform static (monotonic) application of load as well as cyclic tests on geosynthetic materials.
G01N 3/06 - Adaptations particulières des moyens d'indication ou d'enregistrement
G01B 11/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la déformation dans un solide, p. ex. indicateur optique de déformation
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
G06T 7/32 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur la corrélation
52.
SYSTEMS AND METHODS FOR ULTRASOUND IMAGING AND FOCUSING
Systems and methods for ultrasound imaging and targeting. The systems and methods can improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). The systems and methods can improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.
G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.
A61F 2/18 - Parties internes de l'oreille ou du nez, p. ex. tympans
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
An exemplary embodiment provides a micro-electromechanical resonator having a positive temperature coefficient of frequency (TCP). Another embodiment provides a method of manufacturing a desired micro-electromechanical resonator, comprising: determining a desired property for the resonator over a predetermined temperature range; selecting one or more dimensions and/or one or more materials of the resonator based on the desired TCP; and providing the resonator with the one or more dimensions and/or one or more materials, in which the desired property can be one or more properties selected from the group consisting of: a temperature coefficient of frequency (TCP); a temperature turnover point; and a frequency shift.
55.
SYSTEMS, METHODS AND APPARATUS FOR DISTRIBUTED ACOUSTIC BEAMFORMING FOR PRACTICAL IOT APPLICATIONS
An acoustic system may include an array of wirelessly coupled acoustic tags, the array including a master tag configured to receive an exciter signal from a device, and at least one helper tag configured to receive the exciter signal from the device and a relayed signal from the master tag.
G01S 1/72 - Radiophares ou systèmes de balisage émettant des signaux ayant une ou des caractéristiques pouvant être détectées par des récepteurs non directionnels et définissant des directions, situations ou lignes de position déterminées par rapport aux émetteurs de radiophareRécepteurs travaillant avec ces systèmes utilisant des ondes ultrasonores, sonores ou infrasonores
G01S 5/22 - Position de source déterminée par coordination de plusieurs lignes de position définies par des mesures de différence de parcours
G01S 15/06 - Systèmes déterminant les données relatives à la position d'une cible
G01S 15/74 - Systèmes utilisant la reradiation d'ondes acoustiques, p. ex. pour l'identification ami–ennemi
G01S 15/88 - Systèmes sonar, spécialement adaptés à des applications spécifiques
G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p. ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré
H04W 4/029 - Services de gestion ou de suivi basés sur la localisation
G01S 13/75 - Systèmes utilisant la reradiation d'ondes radio, p. ex. du type radar secondaireSystèmes analogues utilisant des transpondeurs alimentés par les ondes reçues, p. ex. utilisant des transpondeurs passifs
An exemplary left ventricular assist device (LVAD) and method that employs design and material designs to reduce the thrombosis risk of LVAD implant in a patient. One feature of the design includes a stented inlet member for the device that can reduce or fully eliminate a flow stasis that can trigger blood protein adsorption that can lead to chain reactions that then result in thrombosis. Other features of the design include (i) a flexible rotor and/or pump housing that can reduce blood damage, (ii) hydrophilic slippery coatings at high sheer components, such as the rotor to further reduce protein adsorption and thus thrombosis risk, (iii) magnetic-based drive and bearing components that can improve the hemocompatibility of the blood pump, and (iv) advanced controls and charging.
A61M 60/117 - Pompes extracorporelles, c.-à-d. que le sang est pompé à l’extérieur du corps du patient pour aider le cœur, p. ex. dans les dispositifs transcutanés ou d’assistance ventriculaire externe
57.
DEVICES AND METHODS FOR CREATING TRANSCELLULAR PORES
Disclosed herein is a biochip with a plurality of endothelial cells (e.g., Schlemm's canal cells) having a plurality of pores (e.g., transcellular pores) and methods of making and using the same.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (USA)
Inventeur(s)
Pandit, Sharbani
Ahamad, Mustaque
Perdisci, Roberto
Sarker, Krishanu
Yang, Diyi
Abrégé
An exemplary system and method are disclosed that is configured to evaluate by interrogation and analysis whether an incoming call from an unknown caller is a robo-call, e.g., a mass-market, spoofed, targeted, and/or evasive robocalls. The exemplary system is configured with a voice interaction model and analytical operation that can first pick up each incoming phone call on behalf of the recipient callee. The exemplary system then simulate natural conversation with the initiating caller by asking/interrogating the caller with a set of pre-stored questions that naturally occur in human conversations. The exemplary system employs the caller's responses to determine whether the call is a robocall or a natural person by assessing via pre-defined analysis for the context and/or expected natural human response.
A system includes a heat-transfer conduit forming a circulating loop with a liquid metal. Heat exchangers are coupled to either end of the circulating loop to transfer heat to and from the liquid metal. A magnetohydrodynamic pump assembly is coupled to the conduit and comprising (i) an electrode configured to generate an electric current density in a first direction, (ii) a magnet configured to generate a magnetic flux density in a second direction perpendicular to the first direction. A resulting Lorentz force between the electrode and the magnet induces motion of the liquid metal in a third direction parallel to the longitudinal axis of the conduit loop. A controller is coupled to the magnetohydrodynamic pump assembly and configured to adjust an electric current applied to the electrode to vary the intensity of the electric current density, which varies a flow rate of the liquid metal.
60.
ELECTRON SHOWER INDUCED DEPOSITION SYSTEMS, METHODS OF USE THEREOF, AND METHODS OF MAKING NANOSTRUCTURES
The present disclosure provides for methods and systems for making structures using a broad electron shower that interacts with a liquid in a high or low vacuum environment. The present disclosure provides for methods and systems for growing of high aspect ratio structures with three-dimensional topological complexity quickly by directing a liquid into an electron shower.
C23C 18/14 - Décomposition par irradiation, p. ex. par photolyse, rayonnement corpusculaire
B05B 1/02 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles
B05B 5/16 - Dispositions pour l'alimentation en liquides ou en autres matériaux fluides
B82Y 40/00 - Fabrication ou traitement des nanostructures
61.
ELECTRODE SYSTEM AND CONTROL MECHANISM FOR ENGINES
An exemplary air-breathing plasma engine and methods of operation are disclosed employing an arc plasma chamber that generates plasma, e.g., electrode-coupled, direct current plasma, via electrodes continuously fed by an electrode-feeding assembly. The plasma chamber can be implemented in any one of the stages following the compression stage and having high-pressure and high-velocity air flow, e.g., for a jet engine, turbojet engine, or rocket engine.
An exemplary embodiment of the present disclosure provides a method of converting formate to a desired compound. The method comprises providing a biocatalyst and formate to form a reaction mixture and reacting at least the biocatalyst with formate to produce a first reaction product.
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
Exemplary geosynthetic apparatus, e.g., geogrid, and designs thereof are disclosed that are configured to restrict displacement of aggregate that mimics biostructures that optimized aperture size, aperture shape and aperture orientation to improve load distribution, improve durability, and/or improve performance in retaining aggregates and other geo materials. The exemplary geosynthetic apparatus as a product is configured as a unit cell in which the center of the unit cell has a primary structure that extend through the center to the edge of the unit cell or one or more intermediate radial position (also referred to as “radial transect boundaries”) therebetween. In embodiments in which the primary structure extends to the transect boundaries through the center of the unit cell, the primary structure are referred to as “radial ribs.”
An exemplary embodiment of the present disclosure provides a system for detecting biomarkers. The system can comprise a composition a first electrode, a second electrode, and an electrical property sensor in electrical communication with the first electrode and the second electrode. The electrical property sensor can be configured to measure an electrical property of the composition. The composition can comprise a molecule of interest configured to bind with a target molecule in a biological sample, a probe molecule configured to bind with the target molecule, and a first metal particle configured to bind with the probe molecule.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
Exemplary air breathing plasma jet engine and method of operation that can be used in electrically powered aircraft and spacecraft as a hybrid between a turbo jet engine and a ramjet or supersonic sonic ramjet (SCRAMJET) engine. The air breathing plasma jet engine includes a compression stage that is configured to compress and slow down incoming air. The compressor can be driven by a high RPM electric motor. The compression stage generates compressed and heated air flow that is passed to a plasma chamber that is configured to add heat to the compressed and heated air flow. The heat are converted to an impulse, e.g., using a converging-diverging (De Laval) nozzle. The system is beneficially configured to reuse the heat byproduct generated in the compression stage.
The Research Institute at Nationwide Children's Hospital (USA)
Georgia Tech Research Corporation (USA)
Inventeur(s)
Krishnamurthy, Rajesh
Dasi, Lakshmi Prasad
Abrégé
A computer-implemented method for predicting risk of ischemia in anomalous aortic origin of a coronary artery (AAOCA) includes receiving medical imaging data of a patient. The method includes extracting, from the medical imaging data, patient-specific morphological imaging biomarkers pertaining to AAOCA and incorporating the biomarkers into a computer model. The method includes simulating, using the computer model, hemodynamics of the patient under simulated stress conditions and a combination of variables, the variables comprising physiological properties of the patient. The method also includes predicting and outputting a patient-specific risk profile of ischemia and/or sudden cardiac death based on simulated hemodynamics.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
67.
SNAKE-SKIN-INSPIRED IN-HOLE BOW SPRING CENTRALIZER
A centralizer device includes a body collar and a tail collar each extending circumferentially around a central axis to define a longitudinal channel. The central axis extends from an up-hole direction towards a downhole direction of the centralizer device. The centralizer device includes a body extending between the body collar and the tail collar. The body includes a first portion, a second portion, and a bow portion that extends radially outward from the central axis to define at least one apex. The body further defines at least one opening. The centralizer device may include a tail extending (i) longitudinally from the tail collar or the body collar and (ii) radially outward from the central axis, the tail comprising a tail tip at a distal end thereof.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
A61K 39/245 - Herpetoviridae, p. ex. virus de l'Herpès simplex
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
69.
ESOPHAGEAL SLEEVE DEVICES AND METHODS OF MAKING THE SAME
Disclosed herein are esophageal sleeve devices comprising bioresorbable scaffolds having a first shape and a second shape. The bioresorbable scaffolds can be made from a shape memory polymer comprising at least one monomer unit of glycerol and at least one monomer unit of dodecanedioate. The bioresorbable scaffolds can also have a functionalized surface modified to have a biology corresponding to a patient. The bioresorbable scaffolds can take the first shape at a first environmental temperature and the second shape at a second environmental temperature. the second environmental temperature being greater than the first environmental temperature. Also disclosed herein are methods of implanting the same.
A61F 2/04 - Éléments ou organes creux ou tubulaires, p. ex. vessies, trachées, bronches ou voies biliaires
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
70.
SOFT WEARABLE PATCH FOR CONTINUOUS CARDIAC BIOMETRIC SECURITY
An exemplary embodiment of the present disclosure provides a biometric identification system, comprising one or more sensors and a controller. The one or more sensors can be configured to generate data corresponding to sounds generated by the heartbeat of a user. The controller can be configured to receive the data and authenticate the user based, at least in part, on the data.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
B81B 7/02 - Systèmes à microstructure comportant des dispositifs électriques ou optiques distincts dont la fonction a une importance particulière, p. ex. systèmes micro-électromécaniques [SMEM, MEMS]
H04R 1/04 - Association constructive d'un microphone avec son circuit électrique
H04R 1/46 - Adaptation particulière pour usage comme microphone de contact, p. ex. sur instrument de musique, sur stéthoscope
Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 8/02 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61Q 19/00 - Préparations pour les soins de la peau
72.
SYSTEMS AND METHODS FOR PREDICTING CARDIAC RISK OF ANOMALOUS AORTIC ORIGIN OF CORONARY ARTERY
THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (USA)
GEORGIA TECH RESEARCH CORPORATION (USA)
Inventeur(s)
Krishnamurthy, Rajesh
Dasi, Lakshmi Prasad
Abrégé
A computer-implemented method for predicting risk of ischemia in anomalous aortic origin of a coronary artery (AAOCA) includes receiving medical imaging data of a patient. The method includes extracting, from the medical imaging data, patient-specific morphological imaging biomarkers pertaining to AAOCA and incorporating the biomarkers into a computer model. The method includes simulating, using the computer model, hemodynamics of the patient under simulated stress conditions and a combination of variables, the variables comprising physiological properties of the patient. The method also includes predicting and outputting a patient-specific risk profile of ischemia and/or sudden cardiac death based on simulated hemodynamics.
73.
Feedback System and Method for Speaker Loudness Correction
An exemplary system and method for a head-worn device for augmenting speech therapy or mitigating Parkinson's effect or other speech-impairing conditions by providing haptic feedback, vibratory feedback, audio feedback, or other stimulations to a wearer by isolating and analyzing vocal/speech output of the user for signal-associated assessment, including, e.g., based on timing, direction, loudness, and/or speaking rate. The haptic biofeedback and/or acoustic/vibratory feedback are beneficially provided to the wearer when (i) certain minimum threshold targets, e.g., relating to the user's loudness or speech rate are not met or (ii) when certain thresholds are exceeded, e.g., for loudness, intensity, or speech rate. The system and method can additionally isolate a detected speech or sound and determine if it is from the user. As a signal-assessment analysis system and method, the implementation can be performed with minimal computation power or resources, e.g., as compared to speech or voice recognition technology.
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
G10L 15/22 - Procédures utilisées pendant le processus de reconnaissance de la parole, p. ex. dialogue homme-machine
74.
UNIVERSAL GRID EDGE ASSET MONITORING SYSTEMS WITH UBIQUITOUS 5G NETWORK ACCESS
An exemplary embodiment of the present disclosure provides a grid edge node, comprising a power supply, one or more sensors, a telecommunications radio, and a backhaul connection. The power supply can be configured to receive input power from a power transformer mounted to a utility pole. The one or more sensors can be configured to monitor one or more conditions of the power transformer. The telecommunications radio can be configured to transmit and receive wireless telecommunications signals to and from remote devices in a telecommunications network. The backhaul connection can be configured to provide communication between the grid edge node and a cloud-based monitoring system. The grid edge node can be configured to transmit data indicative of the one or more monitored conditions to the cloud-based monitoring system via the backhaul connection. The grid edge node can be further configured to be mounted to the utility pole.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
Systems, devices, and methods for manufacturing radiation detection devices. The radiation detection device comprises a silicon layer having at least a first side and a second side. The device may further comprise a first tunnel oxide layer having at least a first side and a second side. The second side of the first tunnel oxide layer may be disposed proximate to the first side of the silicon layer. The device may also comprise a first doped layer disposed proximate to the first side of the first tunnel oxide layer.
H01L 31/02 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails - Détails
H01L 27/14 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des composants semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit ra
H01L 31/0256 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par les matériaux
H01L 31/18 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives
77.
LYMPHOID TISSUES WITH SWITCHABLE PROTEIN GRADIENTS
An organ-on-chip system having a gradient of a stimulating agent (e.g., chemokine) and a plurality of immune cells expressing different phenotypes relative to their placement within the gradient and methods of using the same.
An exemplary embodiment of the present disclosure provides a composition comprising a bead having on its surface a molecule of interest configured to bind with a target molecule in a biological sample, a probe molecule configured to bind with the target molecule, and a metal particle configured to bind with the probe molecule. In any of the embodiments disclosed herein, the bead can comprise an identifying characteristic. In any of the embodiments disclosed herein, the metal particle can be configured to modify an electrical property of the bead. In any of the embodiments disclosed herein, the molecule of interest can comprise one or more of: an antigen, an epitope, an antibody, protein, DNA, RNA, virus, bacteria, and mammalian cell. In any of the embodiments disclosed herein, the target molecule can comprise one or more of: an antibody, a paratope, a protein, DNA, RNA, a virus, a bacterium, and a mammalian cell.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/553 - Support métallique ou recouvert d'un métal
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
79.
ELECTROMAGNETIC METASTRUCTURES FOR RADOME OR ANTENNAE
A frequency selective structure (FSS), e.g., metamaterial, is disclosed that can be used for structural and electromagnetic (EM) purposes in a radome or antenna structure. The FSS may be used as the core dielectric to provide both mechanical rigidity and to provide an electromagnetic (EM) response that is sculpted for transmission, reflection, and/or absorption of an impinging EM wave. To this end, the FSS can facilitate dual-purpose use (or multi-purpose use).
H01Q 15/00 - Dispositifs pour la réflexion, la réfraction, la diffraction ou la polarisation des ondes rayonnées par une antenne, p. ex. dispositifs quasi optiques
H01Q 1/42 - Enveloppes non intimement mécaniquement associées avec les éléments rayonnants, p. ex. radome
80.
Evaporative embedded thermal management of electric motor
A cooling system for an electrical winding (14) includes a winding liner (100) that has at least one wall (102) that defines a plurality of channels (110) that are in communication with the winding (14). A coolant has a liquid state (112) and a gaseous state (114). The coolant passes through the channels (110) so that the coolant is in contact with at least a portion of the electrical winding (14). The coolant has a heat of evaporation such that at least a portion of the coolant evaporates as the coolant absorbs heat from the electrical winding (14). A delivery mechanism (200) delivers the coolant to the channels (110). A heat exchanger (212) cools the coolant after the coolant has passed through the channels (110) to condense the coolant into the liquid state.
H02K 9/20 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p. ex. de l'huile dans lesquels l'agent de refroidissement se vaporise dans l'enveloppe de la machine
H02K 3/30 - Enroulements caractérisés par leur matériau d'isolement
H02K 9/193 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p. ex. de l'huile avec des moyens de remplissage de l'agent de refroidissementDispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p. ex. de l'huile avec des moyens pour empêcher les fuites de l'agent de refroidissement
An exemplary embodiment of the present disclosure provides a micro-robot comprising a body, a helical ridge disposed on an exterior surface of the body, and at least one end effector coupled to the body. At least a portion of the micro-robot can comprise a magnetic material. The micro-robot can be configured to be inserted into a patient's body. The micro-robot can be further configured to be manipulated via a magnetic stimulus external to the patient's body.
The present disclosure relates to anti-SARS-CoV-1 and anti-SARS-CoV-2 activatable RNase guide sequences and methods of use for screening, treating, and/or preventing SARS infections and/or COVID-related diseases.
A physiological monitoring device (200) for application to a user's skin (10) employs a clinical-grade medical film (202) with a skin-compatible adhesive (402) disposed on the bottom side (201). Electrodes (420) are disposed on the bottom side (201) and sense a physiological metric from the user's skin (10). An elastomeric membrane (440) is integrated with the top side of the clinical-grade medical film (202). Undulated wires (430) are on an elastomeric membrane. An electronic circuit (204) is disposed on the elastomeric membrane (440) and is electrically coupled to the electrodes (420) via the undulated wires (430). The electronic circuit (204) senses the physiological metric from the electrodes (420), converts the physiological metric to a digital value, and stores the digital value for communication of the digital value to a remote device (210).
This invention relates to rapid, novel, high-efficiency bacterial recovery systems, kits, and methods that remove essentially all blood background, while maintaining bacterial viability. This approach couples selective hemolysis with centrifugation through a separating material for rapid recovery of near-pure bacteria with minimal sample handling.
A distributed control system and method for decentralized, collaborative platform navigation, routing, and/or control are disclosed employing a distributed, factorized positioning, navigation, and timing chain that can link platforms or nodes having local sensors together by their local inertial and ranging measurements. In the distributed, factorized PNT chain, each platform maintains and contributes local measurements as states to a set of dynamically assigned parent node for a platform cluster, each parent nodes and associated clusters links to at least one other parent node aggregates the states of the platforms in the cluster and passes/propagates states of a linked clustered.
G01C 21/16 - NavigationInstruments de navigation non prévus dans les groupes en utilisant des mesures de la vitesse ou de l'accélération exécutées à bord de l'objet navigantNavigation à l'estime en intégrant l'accélération ou la vitesse, c.-à-d. navigation par inertie
G01C 21/20 - Instruments pour effectuer des calculs de navigation
G05D 1/695 - Commande coordonnée de la position ou du cap de plusieurs véhicules pour maintenir la position des véhicules les uns par rapport aux autres, p. ex. pour les voyages en convoi ou les vols en formation
G05D 101/00 - Détails des architectures logicielles ou matérielles utilisées pour la commande de la position
86.
POINT-OF-CARE ASSAY FOR OCCLUSIVE PLATELET THROMBOSIS
Provided herein is a system for measuring occlusive blood clots, the system comprising: a testing device having at least one channel through which a sample of blood flows; a pump for generating a pressure in the testing device to facilitate the flow of blood; and a controller configured to measure a total volume or mass of blood that flows through the plurality of channels prior to occlusion, wherein the total volume or mass of blood is indicative of occlusion time. Also provided are methods of using the system.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G01N 11/04 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p. ex. un tube, une ouverture
87.
TISSUE SCAFFOLD IMPLANT DEVICES FOR STENOTIC LUMENS
A tissue scaffold implant for expanding a stenotic lumen is provided that includes a bridge structure defining at least two angled sides and a lateral anchor integrally formed with the bridge structure. The lateral anchor is configured to be disposed against at least a portion of an external circumference of the stenotic lumen in a region near an opening formed in the stenotic lumen. At least two seat regions are defined between the at least two angled sides of the bridge structure and the lateral anchor. The at least two seat regions are configured to be received within and support the opening within the stenotic lumen, and the bridge structure and lateral anchor comprise a bioacceptable material.
An exemplary cellular analysis system and method are disclosed that can determine epithelial cell membrane properties by fitting electrochemical impedance spectroscopy (EIS) measurements to (i) an intracellular circuit model having electrical property parameters of the epithelial cell membrane properties, including the apical, basolateral, and shunt pathways or (ii) an extracellular circuit model. The exemplary cellular analysis system and method can be used to measure membrane properties of epithelial electrophysiology that can beneficially be used to assess for transport dysfunction and/or evaluate cellular drug responses in disease models. An exemplary cellular analysis system and method are disclosed that can determine the polarization of epithelial cells in response to stimuli as a time-constant impedance-associated ratio (tau ratio) that can be used in a massively parallel screening system for drug discovery.
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
An example method of estimating an arc duration in a circuit breaker includes receiving a first measurement corresponding to a low-frequency electric field emitted from a vacuum circuit breaker during an interruption or circuit break operation and a second measurement corresponding to a low-frequency magnetic field, vibration, or acoustic emitted by the vacuum circuit breaker during operation, aligning the first measurement and the second measurement in time, wherein the first measurement is calibrated according to a first physical constant and wherein the second measurement is calibrated according to a second physical constant; and determining, by a sensor-fusion algorithm or a trained AI model, an estimated duration value of an arc duration using the time-aligned first measurement and second measurement, wherein the arc duration corresponds to a first time corresponding to a separation of contacts of the vacuum circuit breaker and a second time corresponding to arc extinction.
A computer that includes a processor and a memory, the memory including instructions executable by the processor to generate background pixels and object pixels and generate background pixel ray data based on the background pixels and object ray pixel data based on the object pixels. The background pixel ray data can be input to a first neural network to generate background neural radiance fields (NeRFs) and the object pixel ray data can be input to a second neural network to generate object NeRFs. An output image can be rendered based on the background NeRFs and the object NeRFs.
The present disclosure relates to anti-influenza activatable RNase guide sequences and their use in methods of treating, preventing, and/or detecting influenza infections.
The present disclosure provides polymers comprising one or more constitutional units derived from a polyol, and one or more constitutional units derived from an optionally substituted lactone, wherein the polymer is at least partially crosslinked. Articles formed from the polymers and methods of manufacturing said polymers are also provided.
C07D 305/14 - Composés hétérocycliques contenant des cycles à quatre chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
C07D 407/02 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles
93.
ACCESSING AND MODULATING THE COLOR AND VIBRANCY OF ANODICALLY COLORING ELECTROCHROMIC MOLECULES
In one aspect, the disclosure relates to anodically coloring organic electrochromic materials as discrete chromophores. The chromophores are UV absorbing in the neutral state and upon oxidation form vibrantly absorbing, colored radical cation and dication species. In an aspect, the disclosed materials include UV absorbing discrete chromophores based on a 2-thiomethyl-dioxythiophene coupled to a triphenylamine or carbazole unit. In another aspect, consideration of steric effects and tuning substituent pattern can lead to new cation radicals that are highly saturated in the colored state and have increased color vibrancy. The chromophores and materials containing the same can be used in electrochromic color-to-clear switching devices including, but not limited to, windows, displays, signs, goggles, glasses, and the like.
A dual-drive power amplifier (PA) where the PA core includes a differential pair of transistors M1 and M2 that are driven by a coupling network having two transmission-line couplers, where a first transmission line section of a coupler is configured to transmit an input signal Vin through to drive a gate of the opposite transistor, while the second transmission line section is grounded at one end and coupled with the first transmission line section such that a coupled portion αVin of the input signal Vin drives the source terminal of a corresponding transistor. The arrangement of the coupling network allows the source terminals to be driven below ground potential. Embodiments disclosed here further provide an input matching network, a driver, an inter-stage matching network, and an output network for practical implementation of the PA core.
H03F 3/24 - Amplificateurs de puissance, p. ex. amplificateurs de classe B, amplificateur de classe C d'étages transmetteurs de sortie
H03F 1/02 - Modifications des amplificateurs pour augmenter leur rendement, p. ex. étages classe A à pente glissante, utilisation d'une oscillation auxiliaire
H03F 1/32 - Modifications des amplificateurs pour réduire la distorsion non linéaire
H03F 1/56 - Modifications des impédances d'entrée ou de sortie, non prévues ailleurs
95.
PROGRAMMABLY DEGRADABLE HYDROGELS FOR FUNCTIONAL MOLECULAR RELEASE
Disclosed herein are compositions including polymers functionalized with oxanorbornadiene ("OND") crosslinkers and various within, where the materials and formulations thereof enable controlled, extended release of cargos such as therapeutic, antigenic, diagnostic, and/or analytical agents. Also disclosed is the use of physical entrapment of the cargo, covalent connection of the cargo to polymer via cleavable linkages, and combinations thereof. These combinations provide different patterns and durations of release of cargo molecules. Also disclosed herein are the methods of making and using the same.
C08F 232/04 - Copolymères de composés cycliques ne contenant pas de radicaux aliphatiques non saturés dans une chaîne latérale et contenant une ou plusieurs liaisons doubles carbone-carbone dans un système carbocyclique ne contenant pas de cycles condensés contenant une seule double liaison carbone-carbone
C08F 234/02 - Copolymères de composés cycliques ne contenant pas de radicaux aliphatiques non saturés dans une chaîne latérale et contenant une ou plusieurs liaisons doubles carbone-carbone dans un hétérocycle dans un cycle contenant de l'oxygène
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
96.
CONSENSUS BUG DETECTION THROUGH MULTI-TRANSACTION DIFFERENTIAL FUZZING
G06F 11/36 - Prévention d'erreurs par analyse, par débogage ou par test de logiciel
G06Q 20/36 - Architectures, schémas ou protocoles de paiement caractérisés par l'emploi de dispositifs spécifiques utilisant des portefeuilles électroniques ou coffres-forts électroniques
97.
PROJECTION TWO-PHOTON LITHOGRAPHY METHOD AND SYSTEM FOR RAPID PRINTING OF 3D STRUCTURES WITH SUB-MICROMETER FEATURES AND POROSITIES
Systems, methods, devices, and compositions of matter for 3D printing methods and systems that can be used for rapid nanoscale 3D printing of large and deterministic 3D structures with sub-micrometer features and porosities. The method includes storing or determining a plurality of interspersed features for a three-dimensional (3D) structure to project as a sequence of sparse images on the same plane to generate closely spaced fine features on a polymer resist; and generating, using the sequence of sparse images, a plurality of patterned light sheet on the polymer resist with a temporally-focused femtosecond pulse, the light sheet having patterns.
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
B29C 64/273 - Agencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE] à pulsationsAgencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE] à modulation de fréquence
The digital suture devices can accurately record electrical activity in muscles, while reducing both tissue damage and increasing ease of use. In some examples, the digital suture device can include an adapter configured to be connected to a data collection and/or stimulus control system. The device can further include a sensor body electrically and mechanically connected to the adapter. The sensor body may include one or more sensor members extending from the adapter. Each sensor member may include a first section distal to the adapter, a second section including one or more arrays of one or more stimulating/sensing sites, and a third section configured to be used with a delivery device. The second section may be disposed between the first section and the third section. Each sensor member may include one or more sets of tissue engaging members disposed along a length of the second section.
Exemplary system and method are disclosed that employ an MR-compatible robotic system having a cantilever arm member comprising an elongated beam to extend into the available clearance space of the bore of an MRI scanner when the patient is inside to position interventional and scanning assisted instruments during an MRI scan. The exemplary MR-compatible robotic system can provide multiple direction of motion in the scanner bore with accuracy of less than 2 mm position error for a heavy payload (e.g., greater than or up to 5 kg) while being made of MR-compatible non-metal material, e.g., PLA, Nylon, fiberglass, Acrylic and other plastics. The MR-compatible robotic system is portable in being movable and not-permanently fixed to the MR scanner to be compatible with any closed bore MR scanners (as well as any open-bore MR scanners).
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G01R 33/58 - Étalonnage des systèmes d'imagerie, p. ex. utilisant des sondes d'essai
100.
Trans-Skull Focused Ultrasound Using Acoustic Hologram and Heterogenous Angular Spectrum Approach, and Hologram Registration
This disclosure describes systems and methods for producing and registration of an acoustic holographic lens for trans-skull focused ultrasound (FUS). In one example embodiment, the lens is produced using a heterogenous angular spectrum approach that performs computations in the frequency domain, enabling pressure fields created with selected frequencies. In another example embodiment, precise registration of the lens with skull geometry is achieved via use of a nonlinear parametric array effect.
