Abstract

In a method for predicting a shape of a DNA structure based on deep learning, a DNA structure graph having nodes and edges based on a DNA structure design is acquired. A DNA structure shape corresponding to the DNA structure design based on the DNA structure graph and a DNA structure shape prediction model is output.

IPC Classes  ?

• G16B 40/30 - Unsupervised data analysis
• G16B 15/20 - Protein or domain folding

Abstract

The present invention relates to: an apolipoprotein E (APOE) antisense oligonucleotide; and a pharmaceutical composition for treating Alzheimer's disease comprising same. The antisense oligonucleotide of the present invention can reduce the expression of the APOE4 variant gene that contributes to increased risk and exacerbation of Alzheimer's disease, and can be used as an RNA therapeutic agent for diseases caused by abnormal levels of APOE proteins or APOE variant genome expression.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present application relates to a method and composition for inducing myogenesis.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C07K 14/475 - Growth factorsGrowth regulators

Abstract

The present invention relates to a prodrug compound activated by a fibroblast activation protein (FAP).

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings

Abstract

The present invention relates to a novel anti-CD40 antibody and use thereof and, more specifically, to a novel anti-CD40 antibody and use thereof, wherein the antibody comprises a complementarity determining region of a specific sequence and exhibits an excellent antagonistic effect by blocking CD40-CD40L signaling. The novel anti-CD40 antibody of the present invention exhibits an excellent antagonistic effect by blocking CD40-CD40L signaling, and thus can be widely used as a preparation for preventing or treating various diseases, such as autoimmune diseases and chronic inflammatory diseases, and as a preparation for inhibiting immune rejection at the time of transplantation.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/12 - Fused cells, e.g. hybridomas
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a probe in which a fluorescence dye-quencher is additionally bound to a fusion peptide to which a cell-penetrating peptide-biomarker binding functional peptide for diseases is bound and, more particularly, to a cell-penetrating peptide-bioactive peptide molecular probe which directly introduces a non-penetrating disease-sensitive important domain into a cell so as to penetrate a target cell and emit fluorescence when bound to a target material, thereby facilitating diagnosis and simultaneously inducing treatment. According to the present invention, compared to conventional staining-based histological disease diagnosis, diseases, such as inflammation, can be identified in a non-invasive and rapid manner, and thus the probe may be useful in diagnosing various inflammatory diseases or monitoring transplant-related inflammatory responses during in vivo transplantation. Also, the probe is applicable to clinical use without undergoing multiple steps and can be mass-produced, and thus, by using this approach, is useful in the development of drug delivery systems and treatment technologies.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 49/00 - Preparations for testing in vivo

Abstract

A liquid additive for an all-solid-state battery capable of operating under conditions of room temperature and low pressure, and an all-solid-state battery including the same. Specifically, by adding a liquid additive having low reactivity with a solid electrolyte and high lithium ion conductivity to an anode layer, a cathode layer, or a solid electrolyte layer, ionic conductivity and current density robustness of the all-solid-state battery can be improved under conditions of room temperature and low pressure.

IPC Classes  ?

• H01M 10/056 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

A method and apparatus for a homomorphic encryption operation are disclosed. A bootstrapping method for a homomorphically encrypted ciphertext includes generating a first ciphertext of a plaintext corresponding to a ciphertext modulus of a third value, based on an input ciphertext of the plaintext corresponding to a ciphertext modulus of a first value and corresponding to a ciphertext modulus of a second value, generating a second ciphertext corresponding to the ciphertext modulus of the second value and corresponding to the ciphertext modulus of the third value, based on the first ciphertext, the second value, and the third value, and generating a third ciphertext of an evaluation result of a target function for the plaintext corresponding to a plaintext modulus of a fourth value, based on the second ciphertext and the target function.

IPC Classes  ?

• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
• H04L 9/30 - Public key, i.e. encryption algorithm being computationally infeasible to invert and users' encryption keys not requiring secrecy

Abstract

A method and apparatus for incremental learning are provided. The method includes performing training of a model for a specific task, calculating an average value of a parameter of the model before training for the specific task and calculating a parameter of the model updated by performing training for the specific task, and changing a parameter of the model to the calculated average value.

IPC Classes  ?

• G06N 3/096 - Transfer learning

Abstract

The present invention relates to a ligand compound that is activated by or binds to a fibroblast activation protein (FAP).

IPC Classes  ?

• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/04 - Organic compounds
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

Provided is an apparatus and a method of desalinating saltwater and transporting hydrogen ions using Ion Concentration Polarization (ICP), the apparatus including: a channel part including a channel allowing saltwater to be introduced thereinto, an ion-selective membrane connected to the channel, and a cathode and an anode for applying a voltage to both ends of the channel; a desalination part configured to obtain fresh water from the saltwater with ionic substances removed from the saltwater by ion concentration polarization in a first region adjacent to the anode of the ion-selective membrane; and a hydrogen gas production part configured to concentrate the ionic substances in a second region adjacent to the cathode of the ion-selective membrane and to reduce hydrogen ions (H+) contained in the ionic substances.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• B01D 61/46 - Apparatus therefor
• B01D 61/54 - Controlling or regulating
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 103/08 - Seawater, e.g. for desalination
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 15/029 - Concentration

Abstract

Provided is an analog-to-digital converter. The ADC includes a plurality of bit detection units. Each of the bit detection unit comprises: a state level determination module including a semiconductor device with a preset threshold voltage to receive an input signal; and an output module connected to the state level determination module and configured to detect and output a binary value corresponding to the input voltage. The bit detection units are configured to match one-to-one with the bits constituting a digital code, respectively. The state level determination module is configured to have a threshold voltage or conductance determined according to the bit of the digital code matched to the bit detection unit. Each of the bit detection units detects and outputs a binary value corresponding to the matched bit of the digital code from the input signal.

IPC Classes  ?

• H03M 1/12 - Analogue/digital converters

Abstract

The present invention relates to novel Bifidobacterium longum SNUG50180, SNUG50432, and SNUG50527, and, more specifically, to: Bifidobacterium longum SNUG50180 having the effects of improving intestinal health and treating or preventing intestinal diseases, Bifidobacterium longum SNUG50432 having an effect of promoting immune anticancer activity and Bifidobacterium longum SNUG50527 having an effect of treating or preventing cancer, which are Bifidobacterium longum strains isolated from the feces of Korean individuals who have not taken antibiotics for at least 6 months; and uses thereof.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/745 - Bifidobacteria
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 35/00 - Antineoplastic agents
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C12R 1/01 - Bacteria or actinomycetales

Abstract

Provided are a zeolite-supported catalyst and a manufacturing method thereof. The zeolite-supported catalyst comprises zeolite and a metal catalyst supported on the zeolite. The zeolite is treated with quaternary ammonium hydroxide before supporting the metal catalyst, and thus has an increase in mesopores and a reduction in Al sites on the outer surface. The manufacturing method of the zeolite-supported catalyst comprises the steps of: preparing zeolite; base-treating the zeolite with quaternary ammonium hydroxide; and supporting a metal catalyst on the base-treated zeolite.

IPC Classes  ?

• B01J 29/40 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
• B01J 23/28 - Molybdenum
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam

Abstract

Proposed herein are a link prediction method and apparatus. The link prediction method that is performed by the link prediction apparatus includes predicting one or more edges having a probability of being connected in the structure of an edge-incomplete graph by entering the edge-incomplete graph into a link prediction model. The link prediction model is a model that performs binary classification by processing at least one edge observed in the structure of the edge-incomplete graph as positive data and processing at least one node pair unconnected in the structure of the edge-incomplete graph as unlabeled data.

IPC Classes  ?

• G06N 5/022 - Knowledge engineeringKnowledge acquisition

Abstract

A quantum computing device according to an aspect of the present disclosure includes an ion trap chip including direct current (DC) electrodes and radio frequency (RF) rails to form a plurality of horizontal traps and one or morevertical traps, and a controller configured to trap ions by controlling the ion trap chip, adjust positions of the ions, and apply laser beam to the ions to perform gate operations. The controller performs traversal gate operations between qubits arranged in the horizontal trap area based on qubit connectivity of only qubits trapped in the same horizontal trap, moves the qubits arranged in the horizontal trap area to the vertical trap adjacent to the horizontal trap area through parallel shuttling, perform quantum error correction, and continues traversal gate operations after shuttling to an adjacent horizontal trap area through parallel shuttling.

IPC Classes  ?

• G06N 10/70 - Quantum error correction, detection or prevention, e.g. surface codes or magic state distillation
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The present invention relates to a tandem light-emitting device and a manufacturing method thereof. The tandem light-emitting device according to the present invention and a display device comprising same have maximized color purity and luminous efficiency, improved on-off response, superb operation life, and low manufacturing costs. In addition, the method for manufacturing a tandem light-emitting device according to the present invention has low manufacturing costs, and can manufacture the tandem light-emitting device of the present invention.

IPC Classes  ?

• H10K 50/19 - Tandem OLEDs
• H10K 50/13 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers specially adapted for multicolour light emission, e.g. for emitting white light comprising stacked EL layers within one EL unit
• H10K 30/15 - Sensitised wide-bandgap semiconductor devices, e.g. dye-sensitised TiO2
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 50/852 - Arrangements for extracting light from the devices comprising a resonant cavity structure, e.g. Bragg reflector pair
• H10K 50/15 - Hole transporting layers
• H10K 50/16 - Electron transporting layers

Abstract

A method including obtaining an input graph including a plurality of network components, where each of the plurality of network components include a plurality of nodes and a plurality of edges, segmenting the input graph into a plurality of partial input graphs, where the plurality of partial input graphs includes a first partial input graph and a second partial input graph, generating network features based on the plurality of partial input graphs, where each of the network features includes a connectivity relation between a network component and an adjacent network component among the plurality of network components in the input graph, transmitting a network feature from the first partial input graph to an adjacent network feature in the second partial input graph to obtain an aggregated network feature, and updating the network features of the plurality of network components based on the aggregated network feature.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/042 - Knowledge-based neural networksLogical representations of neural networks

Abstract

The present invention relates to a technique capable of selectively removing abnormal pluripotent stem cells by using metabolic characteristics thereof during stem cell culturing and, more specifically, to a technique capable of selectively removing only mutant pluripotent stem cells while minimizing effects on normal pluripotent stem cells by inducing ferroptosis. Provided in the present invention is a method for identifying metabolic characteristics caused by genetic mutations in genetically mutated pluripotent stem cells and easily and quickly removing the mutated pluripotent stem cells through treatment with a compound that acts on the metabolic characteristics, and thus the present invention can contribute to overcoming major technical limitations during the clinical use of pluripotent stem cells.

IPC Classes  ?

• C12N 5/074 - Adult stem cells
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells

Abstract

The present invention relates to novel lipid nanoparticles capable of liver-specific delivery of mRNA, a manufacturing method therefor, and a liver disease therapeutic agent capable of regenerating the liver by liver-specific delivery of the bio-reprogramming factor mRNA using same. The lipid nanoparticles according to the present invention allow for liver-specific delivery of mRNA at very high efficiency, and the lipid nanoparticles that encapsulate the mRNA-based bio-reprogramming factor mRNA are specifically delivered to liver tissues of an individual requiring liver regeneration to induce short-term expression, thereby easily setting the dose and expression period of a therapeutic agent, leading to a significant reduction in side effects of a therapeutic agent for liver regeneration using an existing cell reprogramming factor.

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a microfluidic chip for cell culture, comprising: an X-direction channel having at least a part extending in an X-direction; a Y-direction channel extending in a vertical direction across the X-direction channel; a Y-positive region channel formed to be in contact with the Y-direction channel in a Y-positive direction; a Y-negative region channel formed to be in contact with the Y-direction channel in a Y-negative direction; a Z-positive region channel formed to be in contact with the Y-direction channel in a Z direction; and a Y-positive direction reservoir surrounding the Y-positive region channel and in contact with the X-direction channel.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

Provided are a method and an apparatus for predicting blood loss in a patient undergoing surgery. The method for predicting blood loss comprises the steps of: detecting a gauze image from a first image of a surgical site of a patient; setting a reference blood color of the patient on the basis of the first image; inputting the reference blood color and the gauze image to a pre-trained blood loss estimation model to estimate the ratio of blood and body fluid absorbed in the gauze; and predicting the amount of lost blood absorbed in the gauze on the basis of the estimated ratio of blood and body fluid.

IPC Classes  ?

• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a method for preventing or treating alternative lengthening of telomeres-positive cancer by identifying factors involved in alternative lengthening of telomeres and correlations therebetween, and by regulating expression of the factors. The present invention provides an effective therapeutic target for alternative lengthening of telomeres-positive cancer, for which an effective treatment method has not yet been developed due to the previously unclear mechanism. Accordingly, the present invention can be effectively used for efficient prevention or treatment of alternative lengthening of telomeres-positive cancer by regulating expression of the target.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention provides a novel compound and a pharmaceutical composition comprising same for preventing or treating diseases associated with a reduction in Sox9 expression. Accordingly, the diseases associated with a reduction in Sox9 expression can be effectively prevented or treated.

IPC Classes  ?

• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond

Abstract

An Interferon Gamma Inducible Protein 16 (IFI16) mutant gene and its use as a marker for predicting, diagnosing, or prognosticating risk or severity of chronic liver disease is described. As a result of performing genomic analysis on NAFLD and NASH patient groups, it was confirmed that the frequency of IFI16 single-nucleotide variants (SNVs) including rs2276404, rs73021847, rs7532207, and rs6940 was increased, and the expression of the IFI16 mutant gene was increased depending on the disease stage of liver disease. The IFI16 SNV was highly expressed in infiltrating macrophages, playing a role in macrophage-induced inflammatory processes, and the IFI16 variant bound more strongly to dsDNA than wild-type IFI16, exacerbating the impaired mitochondrial DNA-sensing response signaling of the IFI16-PYCARD-CASP1 pathway. Thus, the IFI16 mutant gene may be used for predicting, diagnosing, or prognosticating risk or severity of chronic liver disease.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Vibrio natriegensVibrio natriegens, which cannot naturally metabolize alginic acid, is transformed to be capable of alginic acid metabolism and used to produce isopentenol. A recombinant Vibrio natriegens imparted with the ability to metabolize alginic acid and provided with an additional isopentenol production pathway was developed and can be used to metabolize alginic acid and produce isopentenol with high productivity.

IPC Classes  ?

• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12P 7/04 - Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
• C12R 1/63 - Vibrio

Abstract

The present invention relates to a surface-modified albumin nano-platform, a method for preparing same, and a composition for diagnosing or treating a disease using same. The surface-modified albumin nano-platform according to the present invention can reduce ingestion by the reticuloendothelial system even when an excess amount of click-functional groups and various delivery substances are conjugated to albumin, by inactivating a click reaction functional group to which a delivery substance on the surface of albumin is not bound, so that the in vivo half-life is greatly increased, and a target molecule or an active substance can be effectively delivered to a target tissue or cell, leading to excellent therapeutic and diagnostic effects.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed is a multi-DOF wearable assistance device, which is worn on a human body and assists movement, including: a plurality of blocks arranged to be spaced apart along the human body; a linear actuator disposed left and right in parallel between the neighboring blocks; and a joint connector providing a joint connection to freely change a connection angle between the block and opposite ends of the linear actuator.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

A time-to-digital converter (TDC) circuit, according to one embodiment of the present invention, may comprise: a processing circuit which generates a first value of a first gain signal indicating a first time sensing range in a first mode and a first value of a second gain signal indicating a second time sensing range in the first mode; a first delay circuit which generates a plurality of first delay signals by delaying an input signal on the basis of the first value of the first gain signal; a first arbiter circuit which generate first results based on each of the plurality of first delay signals and a first clock signal; a second delay circuit which generates a plurality of second delay signals by delaying the input signal on the basis of the first value of the second gain signal; a second arbiter circuit which generates second results based on each of the plurality of second delay signals and the first clock signal; and an adder circuit which generates a first sum result on the basis of the first results and the second results.

IPC Classes  ?

• H03M 1/50 - Analogue/digital converters with intermediate conversion to time interval
• H03L 7/085 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal

Abstract

This method of a base station for allocating a visible region (VR) in a communication system having a plurality of antennas may comprise the steps of: acquiring location information of a second UE making an initial access; selecting, from among UEs communicating with the base station, a first UE, which is closest to the second UE; transmitting a first RS to the second UE through a first VR allocated to the first UE from among XL-MIMO antennas; receiving, from the second UE, a first report message including a measurement value for the first RS measured by the second UE; and allocating the first VR to the second UE if it is determined, on the basis of the first report message, that the second UE can use the first VR, and the first UE and the second UE can share the first VR through a multiplexing method.

IPC Classes  ?

• H04B 7/0452 - Multi-user MIMO systems
• H04W 72/044 - Wireless resource allocation based on the type of the allocated resource
• H04W 72/51 - Allocation or scheduling criteria for wireless resources based on terminal or device properties
• H04W 72/542 - Allocation or scheduling criteria for wireless resources based on quality criteria using measured or perceived quality
• H04W 72/543 - Allocation or scheduling criteria for wireless resources based on quality criteria based on requested quality, e.g. QoS
• H04B 17/318 - Received signal strength
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

A nano electromechanical neuron device based on a spiking neural network, includes: a first gate electrode receiving a first voltage; a second gate electrode disposed in parallel and spaced apart from the first gate electrode and receiving a second voltage; a drain electrode disposed at a predetermined distance from one end of the first gate electrode and receiving a spike current signal; a movable beam disposed between the first and second gate electrodes and bending in a direction toward the drain electrode according to a spike current signal; and an anchor for securing the movable beam to a lower layer.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

A beam control method using a multi-sensor in a millimeter-wave and terahertz-wave wireless communication system comprises the steps of: diving a beamforming region and performing beam sweeping by a base station; specifying, through beam sweeping, a divided region in which the strength of a received signal is the strongest; obtaining image information through at least one sensor included in a wireless terminal or a base station located in the specified divided region; identifying a target terminal to be communicated, by using the obtained image information, and extracting location information of the identified target terminal; and transmitting data in a direction corresponding to the location information of the identified target terminal. Accordingly, it is possible to greatly increase the accuracy of beamforming in a wireless communication environment, and reduce power consumption, a radio resource overhead, and a delay time required for beamforming.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

A method for providing a user interface for controlling a magnetic catheter by changing an external magnetic field, including steps of: acquiring a k-th subject spatial image by photographing a subject space from a k-th subject spatial absolute coordinate point, displaying a k-th selection indicating symbol at a k-th subject spatial relative coordinate point, which is a relative coordinate point selected by a user with respect to the k-th subject spatial absolute coordinate point as its origin, displaying a k-th visualized coordinate space to expose a yaw and a pitch of a current direction of the magnetic catheter, and continuously exposing the yaw and the pitch of the current direction of the magnetic catheter as time passes.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

A stream control system for many-to-many streaming services includes a plurality of client devices receiving a bitrate map including identification information for at least one transmitting client device from a media server, grade information of a transmission stream transmitted by each transmitting client device, and bitrate information for each grade of the transmission stream, generating a selection table including a plurality of combinations of reception streams and selecting a combination of reception streams based on a frame delay time, and a media server receiving encoded media from at least one transmitting client device and transmitting the media to at least one receiving client device, wherein the client device determines the frame delay time based on transmission start time information inserted into a media frame received from the transmitting client device and an arrival time of the media frame.

IPC Classes  ?

• H04L 65/613 - Network streaming of media packets for supporting one-way streaming services, e.g. Internet radio for the control of the source by the destination

Abstract

An electronic device includes one or more processors configured to measure importance and inference time for a plurality of blocks in which consecutive linear layers are merged, detect a location of a nonlinear layer maximizing the importance when the inference time is limited, using a dynamic programming algorithm, remove the remaining nonlinear layers except for the nonlinear layer at the detected location, and merge adjacent linear layers by removing the remaining nonlinear layers.

IPC Classes  ?

• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
• G06N 3/0985 - Hyperparameter optimisationMeta-learningLearning-to-learn

Abstract

The present invention relates to a combination regimen of Decitabine and Belotecan for preventing or treating ovarian cancer, and provides a pharmaceutical composition for preventing or treating ovarian cancer, the pharmaceutical composition being characterized by comprising Decitabine or a pharmaceutically acceptable salt or solvate thereof as an active ingredient, wherein the pharmaceutical composition is administered in combination with Belotecan or a pharmaceutically acceptable salt or solvate thereof.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A23K 20/137 - Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen

Abstract

The present invention relates to an antibody or an antigen-binding fragment thereof comprising a single domain antibody specifically binding to mesothelin, an antibody conjugate comprising same, a pharmaceutical composition for preventing or treating cancer or a tumor, and a composition for diagnosing or monitoring cancer or a tumor. When the antibody or composition comprising same is used, mesothelin-related cancer or tumors can be effectively prevented, treated, or diagnosed.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a spiking artificial neural network-based nanoelectromechanical neuron device, the device comprising: a first gate electrode receiving a first voltage; a second gate electrode disposed in parallel with the first gate electrode while being spaced apart from the first gate electrode at a predetermined interval, and receiving a second voltage; a drain electrode disposed to be spaced apart from one end of the first gate electrode at a predetermined interval and receiving a spike current signal; a movable beam disposed between the first gate electrode and the second gate electrode and bent in the direction of the drain electrode according to the spike current signal; and an anchor fixing the movable beam to a lower layer. Therefore, the present invention can implement an integrate & fire (IF) neuron by using a nanoelectromechanical (NEM) relay switch, thereby providing high integration and low power compared to existing complementary metal oxide semiconductor (CMOS)-based neurons.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

A system for controlling streams according to the present invention comprises: a plurality of client devices that receive, from a media server, a bitrate map including identification information for each of one or more transmission client devices, rating information about a transmission stream transmitted by each of the one or more transmission client devices, and bitrate information about each rating of transmission streams, generate, on the basis of the bitrate map, a selection table composed of combinations of a plurality of reception streams including the ratings of the transmission streams to be received from the transmission client devices and a summed bitrate obtained by summing a bitrate of each of the ratings of the transmission streams, and select the combinations of the reception streams on the basis of a frame delay time; and the media server that receives media encoded from each of the one or more transmission client devices, and transmits the media to one or more reception client devices. The client devices determine the frame delay time on the basis of transmission start time information inserted into a media frame received from the transmission client devices and an arrival time of the media frame.

IPC Classes  ?

• H04N 21/2662 - Controlling the complexity of the video stream, e.g. by scaling the resolution or bitrate of the video stream based on the client capabilities
• H04N 21/2343 - Processing of video elementary streams, e.g. splicing of video streams or manipulating encoded video stream scene graphs involving reformatting operations of video signals for distribution or compliance with end-user requests or end-user device requirements
• H04N 21/647 - Control signaling between network components and server or clientsNetwork processes for video distribution between server and clients, e.g. controlling the quality of the video stream, by dropping packets, protecting content from unauthorised alteration within the network, monitoring of network load or bridging between two different networks, e.g. between IP and wireless
• H04L 7/00 - Arrangements for synchronising receiver with transmitter
• H04N 7/15 - Conference systems

Abstract

The present invention relates to performance measurement technology performed in a performance measurement device for a very long instruction word (VLIW) processor, the technology comprising the steps of: calculating a scale factor in an operation process based on operation instructions input to the performance measurement device; generating, on the basis of the scale factor, an operation (OP) count value corresponding to the operation instructions; and calculating the energy of the VLIW processor on the basis of the OP count value, wherein the energy may include inter-instruction energy for a plurality of vector operations of the operation instructions.

IPC Classes  ?

• G06F 11/22 - Detection or location of defective computer hardware by testing during standby operation or during idle time, e.g. start-up testing
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 7/523 - Multiplying only

Abstract

A modulation doping-based high-mobility semiconductor device according to an embodiment of the present invention comprises: a substrate; a channel layer formed on the substrate; a doped layer stacked on the channel layer and band-aligned with the channel layer to be heterojunctioned with the channel layer; an oxide layer formed on the doped layer and a spacer region of the channel layer; and a first electrode and a second electrode coupled to both end portions of the channel layer, respectively, wherein the oxide layer is formed by oxidizing an initial doped layer and the spacer region of the channel layer before an oxidation process through a monolithic oxidation process.

IPC Classes  ?

• H10D 30/47 - FETs having zero-dimensional [0D], one-dimensional [1D] or two-dimensional [2D] charge carrier gas channels having 2D charge carrier gas channels, e.g. nanoribbon FETs or high electron mobility transistors [HEMT]
• H10D 62/80 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials
• H10D 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

The present disclosure relates to a neuromorphic memory device and a neuromorphic system using the same. The neuromorphic memory device includes a three-dimensional memory element including NAND cell strings, a bit line that outputs an output signal, forms a first axis of the three-dimensional memory element, and connects NAND cells existing on the same first axis among the NAND cell strings, a word line that receives an input signal, forms a second axis of the three-dimensional memory element, and connects NAND cells existing on the same second axis among the NAND cell strings, and a string selection line that forms a layer of an artificial intelligence neural network, forms a third axis of the three-dimensional memory element, and connects NAND cells existing on the same third axis among the NAND cell strings by intersecting the bit line and the word line.

IPC Classes  ?

• G11C 16/04 - Erasable programmable read-only memories electrically programmable using variable threshold transistors, e.g. FAMOS
• G11C 16/24 - Bit-line control circuits
• G11C 16/26 - Sensing or reading circuitsData output circuits

Abstract

An accelerator for processing a point cloud deep neural network according to an aspect of the present specification includes at least one distance calculator configured to calculate a distance between two points different from each other, wherein the distance calculator includes a first calculation unit, a second calculation unit, and a third calculation unit, and the first calculation unit, the second calculation unit, and the third calculation unit are driven serially to calculate distances on three axes between the two points in a first operation mode, and are driven in parallel to respectively calculate the distances between different pairs of points, in a second operation mode.

IPC Classes  ?

• G06T 7/50 - Depth or shape recovery

Abstract

The present disclosure relates to a novel regulatory element for enhancing RNA stability or mRNA translation; ZCCHC2 interacting with the regulatory element; and uses thereof. Being capable of increasing the expression of a target protein, the novel regulatory element for enhancing RNA stability or mRNA translation; and ZCCHC2 interacting with regulatory element according to the present disclosure are applicable in various fields, depending on the uses of the target protein.

IPC Classes  ?

• C12N 15/67 - General methods for enhancing the expression
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A diffusing capacity predicting apparatus according to the present disclosure includes a memory including one or more instructions and a processor which executes the one or more instructions stored in the memory. In the memory, first information about a spirometry result of a user, second information which is clinical information, a first machine learning model, and a second machine learning model are recorded. The processor inputs the first information to the first machine learning model to extract a feature related to a lung disease and inputs the extracted feature and the second information to the second machine learning model to predict a diffusing capacity value of the user. Accordingly, the diffusing capacity may be more accurately predicted using the spirometer result and the artificial intelligence model, without using the diffusing capacity test method.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A breast cancer risk prediction device includes a memory storing a risk level prediction program and a processor configured to execute the risk level prediction program, wherein the risk level prediction program calculates a breast cancer occurrence rate by applying questionnaire responses on multiple breast cancer occurrence factors to an occurrence rate calculation model, and outputs a breast cancer occurrence risk level according to the breast cancer occurrence rate, and the occurrence rate calculation model calculates the breast cancer occurrence rate by using an equation for calculating a correlation between the multiple breast cancer occurrence factors and breast cancer occurrence by using the multiple breast cancer occurrence factors for a non-patient cohort who does not have a certain disease.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

Disclosed are a polymer including a structural unit represented by Chemical Formula 1, an organic semiconductor material, and a stretchable polymer thin film and an electronic device including the same. Disclosed are a polymer including a structural unit represented by Chemical Formula 1, an organic semiconductor material, and a stretchable polymer thin film and an electronic device including the same. Disclosed are a polymer including a structural unit represented by Chemical Formula 1, an organic semiconductor material, and a stretchable polymer thin film and an electronic device including the same. The definition of Chemical Formula 1 is as described in the detailed description.

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

A transceiver connected to a specific channel via a channel connection node, the transceiver includes a transmitter driving a first node and a second node based on an input data signal in a transmission mode, the first node connected to the channel connection node; a receiver receiving a specific channel signal from the channel connection node and providing an output data signal based on the channel signal and an input differentiation signal in a reception mode, the input differentiation signal being generated based on at least one first output differentiation signal; and a switch network circuit connected between the second node and the channel connection node. The switching network circuit has a first circuit in the transmission mode and a second circuit in the reception mode, and provides at least one second output differentiation signal by differentiating the channel.

IPC Classes  ?

• H04B 1/44 - Transmit/receive switching
• H04B 1/405 - Circuits using the same oscillator for generating both the transmitter frequency and the receiver local oscillator frequency with multiple discrete channels

Abstract

The present invention relates to a method for training a model for predicting abdominal surgery information, which is performed by a computing device, the method comprising a step of training an artificial neural network model by using medical image data and masking data labeled with the degree of adhesion between the peritoneum and organs such that, when a medical image is input, the model outputs abdominal surgery-related information of the input medical image.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G06N 3/08 - Learning methods
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A mixture-of-experts artificial intelligence model according to the present invention comprises: a CXL control unit that manages a CXL protocol; an NDP control unit that includes a memory mapping register set for communicating with a host; a memory unit composed of a plurality of memory chips that provide a memory capacity to the host; and an NDP core unit that processes MoEs existing in the memory unit, wherein the NDP core unit transmits only hot experts to a GPU accelerator while memory-based calculation is performed on cold experts that exist in the memory unit.

IPC Classes  ?

• G06N 3/042 - Knowledge-based neural networksLogical representations of neural networks
• G06N 3/065 - Analogue means

Abstract

A semiconductor memory device according to the present disclosure comprises: a substrate; a hafnium zirconium oxide thin film formed by depositing hafnium oxide and zirconium oxide on the substrate; and a second electrode formed by depositing a metal on the hafnium zirconium oxide thin film, wherein an oxygen vacancy is formed in an upper portion of the hafnium zirconium oxide thin film.

IPC Classes  ?

• H10B 51/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory transistors characterised by the memory core region
• H10D 64/68 - Electrodes having a conductor capacitively coupled to a semiconductor by an insulator, e.g. MIS electrodes characterised by the insulator, e.g. by the gate insulator
• H10D 30/60 - Insulated-gate field-effect transistors [IGFET]
• H10D 48/00 - Individual devices not covered by groups

Abstract

The present disclosure relates to a biomarker for use in the diagnosis or prognostic evaluation of periodontitis, particularly the grade, stage, severity, and/or aggressiveness of periodontitis, and more specifically, the aggressiveness of periodontitis. The present disclosure can be utilized for the early diagnosis and prediction of aggressive periodontitis, aids in developing personalized treatment strategies for each patient with periodontitis, and may greatly improve the clinical management of aggressive periodontitis.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody

Abstract

A semiconductor transistor according to an embodiment of the present invention includes: a substrate; a gate layer formed on the substrate; a channel layer formed on the substrate; an insertion layer formed at an interface between the gate layer and the channel layer; and a first electrode and a second electrode coupled to respective ends of the channel layer, wherein the insertion layer is formed on a surface of the gate layer via a monolithic oxidation process.

IPC Classes  ?

• H10D 30/87 - FETs having Schottky gate electrodes, e.g. metal-semiconductor FETs [MESFET]
• H10D 62/13 - Semiconductor regions connected to electrodes carrying current to be rectified, amplified or switched, e.g. source or drain regions
• H10D 8/60 - Schottky-barrier diodes
• H10D 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

A memory device includes a plurality of memory cells; a plurality of bit lines respectively connected to the plurality of memory cells; a plurality of separation switches, each being arranged in a central separation region of each bit line for each bit line and separating the central separation region of each bit line in response to a separation signal or connecting separated central separation regions to each other in response to the separation signal; a plurality of sharing switches, each being arranged between adjacent bit lines and separating the adjacent bit lines from each other or connecting the adjacent bit lines to each other in response to a charge sharing signal; and at least one ground switch connected to one end portion of each bit line for each bit line and selectively grounding each bit line.

IPC Classes  ?

• G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only
• G11C 5/06 - Arrangements for interconnecting storage elements electrically, e.g. by wiring
• G11C 11/419 - Read-write [R-W] circuits

Abstract

A memory device includes a plurality of memory cells, each being configured to perform in-memory computing; a storage unit storing data; and an operation circuit including a first capacitor and a second capacitor and configured to adjust a voltage charged to the first capacitor and a voltage charged to the second capacitor according to input data and storage data stored in the storage unit.

IPC Classes  ?

• G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only
• G11C 5/14 - Power supply arrangements
• G11C 11/419 - Read-write [R-W] circuits

Abstract

The present disclosure relates to a Alzheimer's disease diagnosis method based on neural population spike signal synchronization, an Alzheimer's disease diagnosis system, and a Alzheimer's disease diagnosis device based on neural population spike signal synchronization including the system, and it has the advantage of being able to be used for the early diagnosis of Alzheimer's disease by calculating an index for evaluating a degree of neural population signal synchronization of neurons and utilizing the same. In addition, the Alzheimer's disease diagnosis method of the present disclosure is based on the fields of neuroscience, medical imaging and brain disease research, and thus provides information related to dementia by analyzing the neural population spike signal synchronization through a more precise method than the existing method, thereby enabling early diagnosis before Alzheimer's disease symptoms appear, and thus, it can be utilized in various medical and research institutions.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/293 - Invasive
• A61B 5/372 - Analysis of electroencephalograms
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A method of preparing a positive electrode active material, a positive electrode and a rechargeable lithium battery are provided. The method of preparing the positive electrode active material includes mixing nickel-manganese-based composite hydroxide and a lithium raw material and subjecting them to primary heat treatment at about 200° C. to about 350° C. and secondary heat treatment at about 800° C. to about 1000° C.

IPC Classes  ?

• C01G 53/504 - Complex oxides containing nickel and at least one other metal element containing alkali metals, e.g. LiNiO2 containing manganese of the type (MnO2)n-, e.g. Li(NixMn1-x)O2 or Li(MyNixMn1-x-y)O2 containing lithium and cobalt with the molar ratio of nickel with respect to all the metals other than alkali metals higher than or equal to 0.5, e.g. Li(MzNixCoyMn1-x-y-z)O2 with x ≥ 0.5
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Provided are a light-emitting diode (LED) device, a method of manufacturing the LED device, and a display apparatus including the LED device. The LED device includes a light-emitting layer having a core-shell structure, a passivation layer provided to cover a portion of a top surface of the first semiconductor layer, a first electrode provided on the light-emitting layer, and a second electrode provided under the light-emitting layer. The light-emitting layer includes a first semiconductor layer, an active layer, and a second semiconductor layer. The first electrode is provided to contact the first semiconductor layer, and the second electrode is provided to contact the second semiconductor layer.

IPC Classes  ?

• H10H 20/821 - Bodies characterised by their shape, e.g. curved or truncated substrates of the light-emitting regions, e.g. non-planar junctions
• H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group
• H10H 20/01 - Manufacture or treatment
• H10H 20/82 - Roughened surfaces, e.g. at the interface between epitaxial layers
• H10H 20/831 - Electrodes characterised by their shape
• H10H 20/84 - Coatings, e.g. passivation layers or antireflective coatings

Abstract

According to a preferred embodiment of the present invention, a method for converting a reproduction pixel interval and a reproduction wavelength of a hologram pattern comprises the steps of: receiving a first complex hologram pattern; converting the first complex hologram pattern into a second complex hologram pattern through an artificial neural network trained to convert a reproduction pixel interval and a reproduction wavelength; and outputting the second complex hologram pattern.

IPC Classes  ?

• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/22 - Processes or apparatus for obtaining an optical image from holograms
• G06N 3/09 - Supervised learning

Abstract

The present invention relates to a method for forming a crystalline thin film and, specifically, to a method capable of forming a single-crystal or polycrystalline thin film without defects regardless of the type of a lower substrate by using a two-dimensional material template.

IPC Classes  ?

• C30B 25/18 - Epitaxial-layer growth characterised by the substrate
• C30B 29/46 - Sulfur-, selenium- or tellurium-containing compounds
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof

Abstract

The present invention relates to a nanoelectromechanical device and a manufacturing method thereof, the device comprising: a first electrode formed on the upper part of a metal wiring layer; a second electrode spaced apart from the first electrode and disposed to be parallel to the first electrode; a movable beam disposed between the first electrode and the second electrode and moving horizontally to come into contact with the first electrode or the second electrode; and a via anchor connected to an upper portion and a lower portion of one side of the movable beam to support the movable beam. Accordingly, the present invention can improve the durability of the device, can operate even at a low driving voltage, and can improve the degree of integration.

IPC Classes  ?

• H10B 69/00 - Erasable-and-programmable ROM [EPROM] devices not provided for in groups , e.g. ultraviolet erasable-and-programmable ROM [UVEPROM] devices
• H10B 99/00 - Subject matter not provided for in other groups of this subclass
• H01H 1/00 - Contacts
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Abstract

The present specification relates to a microRNA biomarker for metabolic disease prediction or diagnosis, and more specifically, by measuring the expression levels of miR 122-5p, miR 93-5p, miR 17-5p, miR 20a-5p, miR 20b-5p, and miR 106a-5p, metabolic disease may be predicted or diagnosed with high accuracy, or a prognosis of metabolic disease may be predicted.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

An apparatus for predicting homologous recombination deficiency (HRD) using artificial intelligence, according to the present invention, comprises: a data collection unit that collects transcript data, gene expression level data, and homologous recombination deficiency score data of various types of cancer patients; a first candidate gene selection unit; a first prediction model generation unit; a second candidate gene selection unit; a third candidate gene selection unit; a second prediction model generation unit; and a homologous recombination deficiency prediction value calculation unit. Accordingly, homologous recombination deficiency for individual samples can be more accurately predicted.

IPC Classes  ?

• G16B 40/20 - Supervised data analysis
• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 30/10 - Sequence alignmentHomology search
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
• G06N 20/00 - Machine learning
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

The present invention relates to a multi-radar synthesis method in a multi-radar synthesis device, the method comprising the steps of: receiving multi-radar data to be synthesized; decoding the multi-radar data by using a library provided in advance; generating plane position indicator (PPI) data by gridding the decoded multi-radar data and aligning same with the grid space of a numerical forecast model; generating constant altitude plane position indicator (CAPPI) data in which the multi-radar data is synthesized by means of PPI data; and converting the CAPPI data into a file of a preset format that is the input form of the numerical forecast model. Therefore, an observation gap due to beam shielding can be replaced with data of other radar points, and a radar synthesis field in which multi-radar data are synthesized can be generated in order to generate, as input data of the numerical forecast model, the multi-radar data collected by radars located at different points.

IPC Classes  ?

• G01S 7/292 - Extracting wanted echo-signals
• G01S 13/95 - Radar or analogous systems, specially adapted for specific applications for meteorological use

Abstract

A nano electromechanical device includes: a first electrode formed on an upper portion of a metal wiring layer; a second electrode spaced apart from the first electrode and arranged in parallel; a movable beam arranged between the first electrode and the second electrode and moving horizontally to contact the first electrode or the second electrode; and a via anchor connected to upper and lower portions of one side of the movable beam and supporting the movable beam. Therefore, the present disclosure can improve the durability of the device, operate at low driving voltage, and improve integration.

IPC Classes  ?

• B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate

Abstract

The present invention relates to a pharmaceutical composition and a skin external application composition for the prevention or treatment of a skin fibrotic disease, each including a Rho-kinase inhibitor as an active ingredient, and a method for preventing or treating a skin fibrotic disease using the same.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/415 - 1,2-Diazoles
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The electrolyte additive for a lithium-ion battery has a minimum electrostatic potential (ESP) of −151 KJ mol-1 to −100 kJ mol-1.

IPC Classes  ?

• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

Proposed is a memory device including a plurality of memory cells performing in-memory computing. Each of the plurality of memory cells includes a storage unit storing data, and an operation circuit that includes a capacitor and controls a voltage charged to the capacitor according to input data and storage data stored in the storage unit.

IPC Classes  ?

• G06F 13/40 - Bus structure
• G11C 7/16 - Storage of analogue signals in digital stores using an arrangement comprising analogue/digital [A/D] converters, digital memories and digital/analogue [D/A] converters
• G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only

Abstract

Provided is a composite solid electrolyte layer having excellent power performance and long-term cycle stability. An embodiment of the present invention provides a composite solid electrolyte layer including a solid electrolyte layer containing a solid electrolyte, an electron blocking layer disposed on at least one surface of the solid electrolyte layer, and a lithiophilic layer disposed on the electron blocking layer.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• C23C 14/06 - Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
• C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
• C23C 14/24 - Vacuum evaporation
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells

Abstract

A data processing apparatus for analyzing a battery manufacturing process, according to one embodiment of the present invention, may comprise at least one processor and a memory that stores at least one instruction to be executed through the at least one processor. Herein, the at least one instruction can include instructions for: collecting process data for each process factor for a plurality of batteries; using the process data for each process factor so as to construct a machine learning-based performance prediction model for predicting battery performance; generating analysis information that indicates the effect of at least one of process factors on a performance prediction value of the performance prediction model; and outputting the generated analysis information through a predefined graphical user interface (GUI).

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
• G06F 9/451 - Execution arrangements for user interfaces
• H01M 10/04 - Construction or manufacture in general
• H01M 4/04 - Processes of manufacture in general
• G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables
• G06F 119/18 - Manufacturability analysis or optimisation for manufacturability
• G06F 111/04 - Constraint-based CAD

Abstract

The present invention relates to a method for manufacturing a pre-lithiated negative electrode, a negative electrode having improved air stability prepared thereby, and a lithium secondary battery comprising the negative electrode, the method comprising the steps of: wetting a negative electrode active material layer including a silicon-based negative electrode active material with a pre-lithiation electrolyte; and bringing a lithium metal layer into contact with at least one surface of the negative electrode active material layer wetted with the pre-lithiation electrolyte, wherein the pre-lithiation electrolyte includes a lithium salt having a concentration of greater than 3M and a non-aqueous solvent.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 10/0566 - Liquid materials
• H01M 10/052 - Li-accumulators
• H01M 10/44 - Methods for charging or discharging
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

The present invention relates to: a separator comprising a porous substrate, a ceramic coating layer provided on at least one of respective surfaces of the porous substrate, and a positively charged self-assembled monolayer provided on the ceramic coating layer; a method for manufacturing the separator; and a secondary battery comprising the separator.

IPC Classes  ?

• H01M 50/451 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising layers of only organic material and layers containing inorganic material
• H01M 50/457 - Separators, membranes or diaphragms characterised by the material having a layered structure comprising three or more layers
• H01M 50/434 - Ceramics
• H01M 50/414 - Synthetic resins, e.g. .thermoplastics or thermosetting resins
• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 10/052 - Li-accumulators
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides

Abstract

The present invention relates to a novel beta-carboline derivative and a composition for preventing or treating drug-resistant cancer comprising same. The β-carboline derivative compounds of the present invention inhibit STAT3 activity in drug-resistant cancer cells and suppress cancer cell invasion and migration, thereby exhibiting anticancer effects. Accordingly, the compounds are expected to be advantageously applicable as an anticancer agent for various cancers including breast cancer and a therapeutic agent for drug-resistant cancer.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 35/00 - Antineoplastic agents

Abstract

An atomically dispersed catalyst and a forming method therefor are provided. The atomically dispersed catalyst comprises a metal oxide support and metal atoms dispersed in the metal oxide support. The atomically dispersed catalyst forming method comprises the steps of: forming a metal oxide dispersion solution and a metal precursor solution; irradiating the metal oxide dispersion solution with light; and adding the metal precursor solution to the metal oxide dispersion solution irradiated with light.

IPC Classes  ?

• B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
• B01J 23/80 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with zinc, cadmium or mercury
• B01J 23/60 - Platinum group metals with zinc, cadmium or mercury
• B01J 23/63 - Platinum group metals with rare earths or actinides
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves

Abstract

The present invention relates to a novel cancer predisposition genes and, more specifically, to a method for providing information for cancer predisposition diagnosis, the method comprising a step of detecting pathogenic germline variants in novel cancer predisposition genes derived from a Mendelian disease-associated gene group, and to a composition, a kit, and a gene analysis panel for cancer predisposition diagnosis, comprising an agent capable of detecting the pathogenic germline variants in the cancer predisposition genes. The novel cancer predisposition genes of the present invention may be very usefully employed for cancer patient prevention and treatment by enabling management, diagnosis, and treatment prior to cancer onset or at an early stage of cancer onset by preemptively identifying cancer risk.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a method for preparing extracellular vesicles derived from glia-like cells differentiated from stem cells, and a composition for preventing or treating nervous system diseases caused by nerve damage, comprising same as an active ingredient. The extracellular vesicles, of the present invention, which are separated after pretreating, with a specific peptide, the glia-like cells differentiated from stem cells, have neuroprotective and regenerative effects, and thus can be effectively used for preventing or treating nervous system diseases caused by nerve damage. In addition, the method for preparing extracellular vesicles, of the present invention, can produce, in a high yield, stem cell-derived extracellular vesicles having a nerve regeneration effect, and thus is useful.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 9/50 - Microcapsules
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to a binder resin for a sulfide-based all-solid-state secondary battery, and an electrolyte layer, a composite negative electrode layer, and a secondary battery comprising same. More specifically, the binder resin according to the present invention can reinforce the bonding between an electrode current collector and an electrode active material, and can enhance adhesion through chemical and physical interactions with the electrode active material to mitigate the thermal expansion of an electrode and the deformation during the lifetime of the electrode, leading to an improvement in the stability of the electrode during charge-discharge cycles of the battery.

IPC Classes  ?

• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

An operation accelerator that performs an operation between a floating point matrix and an integer matrix includes a first buffer storing integer matrix data; a second buffer storing floating point matrix data; a data converter to convert the floating point matrix data into an integer; and an operator to perform multiplication on the integer matrix data and integer operation target matrix data output from the data converter, wherein the data converter includes a pre-aligner to find a maximum exponent value among multiple floating point values included in the floating point matrix data, perform pre-alignment for moving a mantissa of each of floating points by a difference between the maximum exponent value and an exponent value of each of the multiple floating point values, and generate the integer operation target matrix data based on mantissas of a preset number of high-order bits extracted from among mantissas of pre-aligned floating point values.

IPC Classes  ?

• G06F 17/16 - Matrix or vector computation
• H03M 7/24 - Conversion to or from floating-point codes

Abstract

An operation accelerator for processing an operation between floating-point data and integer data includes a data converter configured to receive one of the integer data and the floating-point data as first input data and to output integer operation target data; a data setting unit configured to divide the integer operation target data into units of a same size and to transmit the integer operation target data to an arithmetic unit; the arithmetic unit configured to perform a multiply and accumulation (MAC) operation on second input data received as an integer and the integer operation target data received from the data setting unit; and a merger configured to adjust an operation result of the arithmetic unit by compensating for an original scale omitted in a process of dividing the integer operation target data into the units of the same size.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation

Abstract

A wireless charging system for an electric vehicle can includes a transmitter including a transmission pad installed separate from the vehicle and configured for generating an electromagnetic field by receiving energy, and a receiver including a reception pad installed inside the vehicle and configured to be disposed to face the transmission pad, and configured for inducting a voltage by the electromagnetic field generated by the transmission pad and charging a battery of the electric vehicle, and the transmission pad can be provided to transmit a maximum output even though the transmission pad is formed to be asymmetric to the reception pad in a width direction of the vehicle.

IPC Classes  ?

• B60L 53/39 - Means for automatic or assisted adjustment of the relative position of charging devices and vehicles specially adapted for charging by inductive energy transfer with position-responsive activation of primary coils
• B60L 53/122 - Circuits or methods for driving the primary coil, i.e. supplying electric power to the coil
• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment

Abstract

An electrocatalyst including: a first nanostructure including copper hydroxide; and a second nanostructure including a metal of Groups 2, 4, or 11 to 14 of the Periodic Table of Elements, other than copper, a metal oxide of the metal, a metal hydroxide of the metal, or a combination thereof, wherein the electrocatalyst is effective to catalyze conversion of carbon dioxide into a multicarbon compound.

IPC Classes  ?

• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 3/26 - Reduction of carbon dioxide
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon

Abstract

A processor-implemented method with image enhancement includes, based on an input image, region information about a local region of the input image, and style information about a target style to be applied to the local region, generating a local feature representation, generating a global feature representation based on the input image, based on the local feature representation, the global feature representation, and the region information, determining an adjustment parameter set, and, based on the adjustment parameter set, generating a retouch result by adjusting the input image.

IPC Classes  ?

• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06T 5/77 - RetouchingInpaintingScratch removal
• G06T 7/11 - Region-based segmentation

Abstract

The present invention relates to a method for manufacturing perovskite nanocrystals having excellent photoluminescence efficiency and capable of realizing pure colors according to the Rec. 2100 (or Rec. 2020) standard, and a light-emitting device comprising the perovskite nanocrystals manufactured thereby.

IPC Classes  ?

• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• C30B 7/14 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
• C30B 29/12 - Halides
• H10K 50/115 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising active inorganic nanostructures, e.g. luminescent quantum dots
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

A memory device including at least one memory cell includes a nonvolatile memory cell; a first switching element having one terminal connected to the nonvolatile memory cell and being switched according to input data; an inverter connected to a multiplication node to which the nonvolatile memory cell and the first switching element are connected; and a capacitor connected to an output node of the inverter, herein the memory cell performs in-memory computing, and the capacitor outputs a computational operation result between storage data stored in the nonvolatile memory cell and the input data.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Embodiments provide a composition, a light-emitting device using the composition, and an electronic apparatus including the light-emitting device. The composition includes a nanomaterial and a solvent, wherein the nanomaterial includes a metal oxide and a ligand on a surface of the metal oxide. The ligand includes a group represented by Formula 1, which is explained in the specification: Embodiments provide a composition, a light-emitting device using the composition, and an electronic apparatus including the light-emitting device. The composition includes a nanomaterial and a solvent, wherein the nanomaterial includes a metal oxide and a ligand on a surface of the metal oxide. The ligand includes a group represented by Formula 1, which is explained in the specification:

IPC Classes  ?

• C09K 11/55 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing beryllium, magnesium, alkali metals or alkaline earth metals
• C09K 11/08 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials
• G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
• H10K 50/115 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising active inorganic nanostructures, e.g. luminescent quantum dots
• H10K 50/16 - Electron transporting layers
• H10K 50/17 - Carrier injection layers

Abstract

A method with a number-theoretic transform (NTT) operation includes allocating an element of a matrix to a data lane such that elements in a first column of the matrix corresponding to a polynomial are allocated to the data lane of a first lane group among lane groups, wherein the matrix is a square matrix, and a number of elements comprised in the matrix is N, performing a first NTT operation on a data lane of a fourth root of the N for each of the lane groups, allocating a result of the first NTT operation to the data lane such that the matrix is transposed, based on adjustment of a reading order of a buffer that stores the result of the first NTT operation, and performing a second NTT operation on the data lane of the fourth root of the N for each of the lane groups.

IPC Classes  ?

• H04L 9/30 - Public key, i.e. encryption algorithm being computationally infeasible to invert and users' encryption keys not requiring secrecy
• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols

Abstract

Provided is a cucumber mosaic virus-based modified recombinant vector. The recombinant vector according to an example may significantly improve the efficiency of foreign protein expression in plants, and are more efficient at expressing a foreign protein than an existing recombinant vector, and thus may be widely utilized for the production of useful proteins in various plant species and for research thereon.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora

Abstract

The present invention relates to a radiant cooling glazing unit for a mobility device, comprising: a first transparent base layer; a first light reflective layer formed on the first transparent base layer and having a reflectance of 80% or more with respect to light having a wavelength of 780 nm to 1,300 nm and a transmittance of 70% or more with respect to visible light having a wavelength of 400 nm to 780 nm; a second light reflective layer formed on the first reflective layer and in which a first metal protection layer, a metal layer, and a second metal protection layer are sequentially laminated; and a second transparent base layer formed on the second light reflective layer.

IPC Classes  ?

• F25B 23/00 - Machines, plants or systems, with a single mode of operation not covered by groups , e.g. using selective radiation effect
• F28F 13/18 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflectingArrangements for modifying heat transfer, e.g. increasing, decreasing by surface treatment, e.g. polishing
• B32B 7/023 - Optical properties
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
• B32B 27/36 - Layered products essentially comprising synthetic resin comprising polyesters
• B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• C09J 129/14 - Homopolymers or copolymers of acetals or ketals obtained by polymerisation of unsaturated acetals or ketals or by after-treatment of polymers of unsaturated alcohols
• C09J 123/08 - Copolymers of ethene
• C09J 175/04 - Polyurethanes

Abstract

Provided is a synthesis method for alkylene carbonate, for example, alkylene carbonate comprising propylene carbonate, ethylene carbonate, and the like and, more specifically to, a synthesis method for alkylene carbonate comprising mixing a liquid compound of chemical formula 1 and hydrogen carbonate (MHCO3). According to the synthesis method of the present invention, use of carbon dioxide, ethylene oxide, propylene oxide, and the like is unnecessary, and alkylene carbonate may be obtained in high yield even under relatively low-temperature atmospheric pressure.

IPC Classes  ?

• C07D 317/38 - Ethylene carbonate
• C07D 317/36 - Alkylene carbonatesSubstituted alkylene carbonates

Abstract

A micro LED pixel circuit driven by a PWM includes a sweep signal generation unit configured to output a sweep signal of which slope is adjusted according to grayscale data, a constant current control unit configured to supply a constant current and controls whether to stop supply of the constant current according to the sweep signal output by the sweep signal generation unit, and a micro LED driven by the constant current.

IPC Classes  ?

• H05B 45/345 - Current stabilisationMaintaining constant current
• G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
• H05B 45/325 - Pulse-width modulation [PWM]

Abstract

A method of forming a high-temperature superconducting single crystal is capable of facilitating a high-temperature superconducting single crystal containing rare-earth metals to grow using a multilayer seed. The method includes: preparing a rare earth barium copper oxide (ReBCO)-based precursor containing rare-earth metals; preparing a plurality of seeds that differ in lattice constant; placing the prepared seeds on top of the precursor through stacking; melting a portion of the precursor by heating the precursor to a peritectic temperature thereof or higher; and growing a single crystal by cooling the precursor to a crystal growth temperature thereof to match a crystal orientation of the seeds. Despite being used to increase the area and maintain the soundness of the single-crystalline specimen in most single-crystal growth, a buffer herein is to facilitate a single crystal of a new composition to grow.

IPC Classes  ?

• C30B 11/14 - Single-crystal-growth by normal freezing or freezing under temperature gradient, e.g. Bridgman- Stockbarger method characterised by the seed, e.g. its crystallographic orientation
• C30B 11/00 - Single-crystal-growth by normal freezing or freezing under temperature gradient, e.g. Bridgman- Stockbarger method
• C30B 29/22 - Complex oxides

Abstract

An embodiment radiative cooling glazing unit includes a first transparent base layer, a first light reflecting layer on the first transparent base layer and having a reflectance of 80% or greater for light with a wavelength of 780 to 1,300 nm and a transmittance of 70% or greater for visible light with a wavelength of 400 to 780 nm, a second light reflecting layer on the first light reflecting layer and including a stack of a first metal protective layer, a metal layer, and a second metal protective layer sequentially stacked on the first light reflecting layer, and a second transparent base layer on the second light reflecting layer.

IPC Classes  ?

• G02B 5/28 - Interference filters
• B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• B60J 1/02 - WindowsWindscreensAccessories therefor arranged at the vehicle front
• C03C 17/36 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with at least two coatings having different compositions at least one coating being a metal

Abstract

Disclosed are a neuron circuit of an artificial neural network and a method for operating the neuron circuit. The neuron circuit includes: a threshold voltage storage unit for storing a threshold voltage of an output transistor in a threshold voltage capacitor; a threshold voltage compensation unit for compensating the potential of the threshold voltage capacitor for the intrinsic threshold voltage of the output transistor; and an output unit for transmitting a constant output value to the next synapse by using the compensated threshold voltage.

IPC Classes  ?

• G06N 3/065 - Analogue means

Abstract

A composition for alleviation or treatment of cerebral infarction sequela includes glia-like cells differentiated from human mesenchymal stem cells (hMSCs). The composition may be used as a therapeutic agent for alleviating or treating one or more cerebral infarction sequela selected from the group including paralysis, dysphagia, cognitive impairment, aphasia and stuttering.

IPC Classes  ?

• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A quantum circuit designing apparatus and method is provided. The quantum circuit designing apparatus includes a processor, and a memory configured to store at least one command to be executed by the processor, wherein the processor removes devices according to importance of each of the devices in a programmable quantum circuit.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present specification relates to a composition for treating or preventing recurrence of chondrosarcoma, and a composition for diagnosing or predicting prognosis of chondrosarcoma. More specifically, i) the composition for treating or preventing recurrence of chondrosarcoma according to one aspect comprises a SIRT1 inhibitor (e.g., EX527, shRNA, nicotinamide), and thus can inhibit chondrosarcoma (or a tumor thereof) and, particularly when used in combination with a commercially available anticancer therapeutic agent (e.g., doxorubicin), can exhibit a synergetic effect in treating chondrosarcoma, and ii) the composition for diagnosing or predicting the prognosis of chondrosarcoma can diagnose chondrosarcoma with high accuracy or predict the prognosis of chondrosarcoma by measuring the expression levels of one or more selected from the group consisting of SIRT1, NAMPT, and NAPRT.

IPC Classes  ?

• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention relates to a method for predicting reactivity to anticancer drugs by analyzing genomic DNA methylation status and, more specifically to a method for predicting reactivity to anticancer drugs by analyzing the methylation status of adjacent CpG sites in genomic DNA. The method of the present invention can accurately predict reactivity to anticancer drugs by using the methylation disorderness of CpG sites in genomic DNA, and thus can be very useful in the selection of drugs for cancer patient treatment.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Disclosed is a CAM device including a memory cell array, a voltage generator that respectively provides input signals to rows of the memory cell array, a driver circuit that respectively provides search signals to columns of the memory cell array and respectively provides complementary search signals to the columns, and a priority encoder connected to the rows. A first row includes first to M-th memory transistors respectively connected to the columns. The first memory transistor includes a first source terminal receiving the first complementary search signal, a first gate terminal receiving the first input signal, a first drain terminal receiving the first search signal, and a first electrical element. When a codeword corresponding to the first search signal and the first complementary search signal corresponds to a programmed state of the first electrical element, a capacitance value of the first memory transistor is smaller than a threshold value.

IPC Classes  ?

• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
• G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements
• H10B 51/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory transistors characterised by the memory core region

Abstract

According to an infinite impulse response layer-based deep neural network system and method proposed in the present invention, the system includes at least one IIR layer, which is a layer for learning IIR filter coefficients corresponding to filter coefficients of an IIR filter among digital filters, so that superior performance can be achieved, compared to an existing convolutional layer-based deep neural network, through an IIR layer capable of modeling a more complex function by means of fewer parameters than an existing convolutional layer interpreted as a layer for learning FIR filter coefficients.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/048 - Activation functions