COMPOSITION FOR ALLEVIATING, TREATING, OR PREVENTING MUSCULAR DISEASES, OR IMPROVING MUSCULAR FUNCTIONS, CONTAINING KOREAN MINT EXTRACT OR TILIANIN AS ACTIVE INGREDIENT
The present disclosure relates to a composition for alleviating, treating or preventing muscular diseases or improving muscular functions, which contains a Korean mint extract or tilianin as an active ingredient. The Korean mint or tilianin according to the present disclosure has effects of increasing the activity of mTOR, which is involved in muscle protein synthesis, and reducing mRNA expression of MuRF-1 and atrogin-1, which are involved in muscle protein degradation. Accordingly, it can be usefully used for prevention, amelioration or treatment of various muscular diseases such as sarcopenia, muscular atrophy, muscular dystrophy, atony, muscular degeneration, myasthenia, cachexia, etc. by increasing muscle mass and improving muscular functions.
A23G 3/48 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition containing plants or parts thereof, e.g. fruits, seeds, extracts
A23G 4/06 - Chewing gum characterised by the composition
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
COMPOSITION COMPRISING CUDRANIA TRICUSPIDATE AS EFFECTIVE COMPONENT FOR ALLEVIATING, TREATING, OR PREVENTING MUSCULAR DISEASES, OR IMPROVING MUSCULE FUNCTIONS
The present disclosure relates to a composition for preventing and treating a muscular disease, or improving muscular function, which contains Cudrania tricuspidata such as a pulverization product or an extract of Cudrania tricuspidata as an active ingredient. The Cudrania tricuspidata according to the present disclosure such as the pulverization product or extract of Cudrania tricuspidata has an effect of increasing the activity of mTOR, which is involved in muscle protein synthesis, and reducing the mRNA expression of MuRF-1 and atrogin-1, which are involved in muscle protein degradation, increases muscle mass and improves muscular function. Therefore, it may be usefully utilized in the prevention, alleviation or treatment of various muscular diseases such as atony, muscular atrophy, muscular dystrophy, muscle degeneration, muscle weakness, cachexia, sarcopenia, etc.
A61K 36/60 - Moraceae (Mulberry family), e.g. breadfruit or fig
A61K 8/9778 - Gnetophyta, e.g. Ephedraceae [Mormon-tea family]
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
3.
COMPOSITION FOR IMPROVING, TREATING, OR PREVENTING MUSCLE DISEASE, OR IMPROVING MUSCLE FUNCTION, CONTAINING ROSE HIP AS ACITVE INGREDIENT
The present invention relates to a novel use of rose hip as ground rose hip or a rose hip extract, and to a composition for improving, treating, or preventing muscle disease, or improving muscle function, containing rose hip as an active ingredient. The composition of the present invention has the effect of increasing the activity of mTOR involved in muscle protein synthesis and reducing the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases muscle mass and enhances muscle function such that the composition of the present invention can be helpfully used for preventing, improving, or treating various muscle diseases such as sarcopenia, muscular atrophy, muscular dystrophy, atony, muscle degeneration, myasthenia, cachexia, etc.
A23K 20/00 - Accessory food factors for animal feeding-stuffs
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
4.
COMPOSITION FOR ALLEVIATING, TREATING, OR PREVENTING MUSCULAR DISEASES, OR IMPROVING MUSCULAR FUNCTIONS, CONTAINING KOREAN MINT EXTRACT OR TILIANIN AS ACTIVE INGREDIENT
The present invention relates to a composition for alleviating, treating, or preventing muscular diseases, or improving muscular functions, containing, as an active ingredient, a Korean mint extract or tilianin. Korean mint or tilianin according to the present invention has effects of increasing the activity of mTOR, which is involved in muscle protein synthesis and reducing mRNA expression of MuRF-1 and atrogin-1 which are involved in muscle protein degradation, and increases muscle mass and improves muscle functions, and thus can be effectively used in preventing, treating or alleviating various muscular diseases, such as sarcopenia, muscular atrophy, muscular dystrophy, atony, muscle degeneration, myasthenia and cachexia.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
A61K 36/03 - Phaeophycota or phaeophyta (brown algae), e.g. Fucus
6.
Use of Kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function
Kaempferia parviflora Wall. Ex. Baker extracts or flavone compound isolated therefrom according to the present invention reduces protein catabolism in the muscles and increases muscle cell differentiation and anabolism, and is thus effective for preparing pharmaceutical composition for treating muscle diseases and dietary composition for improving muscle function.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 31/35 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
7.
COMPOSITION CONTAINING SQUALENE FOR IMPROVING MUSCLE FUNCTION AND PREVENTING MUSCLE DAMAGE
The present invention relates to a composition for preventing, treating, improving a muscle disease or regenerating muscle damage, containing squalene. More specifically, the squalene of the present invention increases the expression of proteins involved in muscle protein synthesis and muscle mass increase in muscle cells, inhibits an expression of enzymes involved in myoprotein degradation at the level of mRNA, and has an effect of restoring the recovery of damaged muscle quickly. Also, the present invention is a natural product so as to be safely used without side effects, and thus can be used as medicine, food, or cosmetics.
A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
Siegesbeckia herba extract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1α, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.
The present invention relates to a composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum ground product, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme ground product or a Sargassum fusiforme extract. According to the present invention, fucosterol, Sargassum fulvellum, a Sargassum fulvellum ground product, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme ground product or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, since the composition of the present invention is a natural product, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 36/03 - Phaeophycota or phaeophyta (brown algae), e.g. Fucus
10.
Boesenbergia pandurata for enhancing muscle mass growth, fighting fatigue, and enhancing exercise performance
Boesenbergia pandurata of the present invention may be used without side effect and has the effect of increasing the expression of PPAR-δ in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
The present invention relates to a pharmaceutical composition containing flavone compound as an active ingredient for treating obesity, and more specifically to a pharmaceutical composition for preventing or treating obesity and a dietary composition for preventing or reducing obesity containing 5,7-dimethoxyflavone or 5,7,4′-trimethoxyflavone. The compound according to the present invention inhibits adipogenesis, and reduces expression of the key transcription factors (SREBP1c and C/EBP) related to lipogenesis and of enzyme proteins (FAS and ACC) related to adipogenesis, and thus is effective in preventing or treating obesity.
A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
12.
Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function
Kaempferia parviflora Wall. Ex. Baker extracts or flavone compound isolated therefrom according to the present invention reduces protein catabolism in the muscles and increases muscle cell differentiation and anabolism, and is thus effective for preparing pharmaceutical composition for treating muscle diseases and dietary composition for improving muscle function.
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A61K 31/35 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
13.
Boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability
Boesenbergia pandurata of the present invention may be used without side effect and has the effect of increasing the expression of PPAR-δ in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes.
The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
A61K 31/36 - Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
17.
Method and composition for treating acne using lignan compounds
The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 31/36 - Compounds containing methylenedioxyphenyl groups, e.g. sesamin
patents
