Aalborg Universitet

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C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides 15
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons 13
A61B 5/04 - Measuring bioelectric signals of the body or parts thereof 6
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb 6
B25J 9/00 - Programme-controlled manipulators 4
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1.

A HYDRAULIC DEVICE

      
Application Number 18713528
Status Pending
Filing Date 2022-11-28
First Publication Date 2025-01-23
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Johansen, Per
  • Hansen, Anders Hedegaard

Abstract

The present invention relates inter alia to a hydraulic device which may be used as a hydraulic transformer. The hydraulic device comprising a housing, a first tubular cavity and a second tubular cavity both being provided within the housing. A piston structure is reciprocatable arranged within the housing and comprises a first piston and a second piston; wherein the first piston divides the first cavity into two chambers, and the second piston divides the second cavity into two chambers. Fluid passages for individually exchanging fluid between the chambers and the exterior of the housing are provided and each fluid passage comprising a controllable shut-off valve so as to provide the reciprocating movement of the piston structure by exchanging fluid between exterior and the two chambers of the first cavity, and said hydraulic transformed being configured to control the shut-off valves to selectively be in a closed state or in an open state.

IPC Classes  ?

  • F15B 11/028 - Systems essentially incorporating special features for controlling the speed or the actuating force or speed of an output member for controlling the actuating force

2.

POWER MODULE WITH REDUCED TRIPLE POINT MAXIMUM ELECTRIC FIELD

      
Application Number EP2024069223
Publication Number 2025/012219
Status In Force
Filing Date 2024-07-08
Publication Date 2025-01-16
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Uhrenfeldt, Christian
  • Gao, Yuan
  • Aunsborg, Thore Stig
  • Munk-Nielsen, Stig

Abstract

The present invention provides a power module, especially configured for Medium Voltage (MV) applications. The power module comprises an electrically non- conductive substrate with first and second electrically conductive pads connected to respective external terminals. The first conductive pad is configured for connection to an electric high voltage (HV) potential, such as in the MV range, e.g. 15 kV, and the second conductive pad is configured for connection to electric ground. A semiconductor chip, such as a Silicon Carbide based chip, is directly secured to the first or the second conductive pad. At least a first electrically conductive guard structure is arranged on the upper surface of the non-conductive substrate so as to form a closed ring around the first conductive pad. This first guard structure is configured for electric connection to an electrical potential between electric ground and the HV potential, such as an electric potential of at least 0.5 times the HV potential, such as 0.7-0.9 times the HV potential. Preferred embodiments illustrate how a voltage divider structure can be integrated into the power module to provide the optimal electric potential for the guard structure to give optimal reduction of maximum electric field in the trench.

IPC Classes  ?

  • H01L 23/24 - Fillings characterised by the material, its physical or chemical properties, or its arrangement within the complete device solid or gel, at the normal operating temperature of the device
  • H01L 23/373 - Cooling facilitated by selection of materials for the device
  • H01L 23/62 - Protection against overcurrent or overload, e.g. fuses, shunts
  • H01L 25/07 - Assemblies consisting of a plurality of individual semiconductor or other solid state devices all the devices being of a type provided for in the same subgroup of groups , or in a single subclass of , , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group

3.

NOVEL FUNGAL DERIVED COMPOUNDS

      
Application Number EP2024055185
Publication Number 2024/184170
Status In Force
Filing Date 2024-02-29
Publication Date 2024-09-12
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Søndergaard, Teis Esben
  • Kristensen, Peter
  • Westphal, Klaus Ringsborg
  • Aalborg, Trine
  • Delényi, Balázs
  • Lunden, Thea Laulund

Abstract

The present invention relates to compounds of Non-Ribosomal Peptide Synthetase and methods of analysing them. In particular the present invention relates to the use of these compounds in vaccines and antigen-binding molecules targeting these compounds.

IPC Classes  ?

  • G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • C07K 14/37 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
  • C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi

4.

A PLANAR WINDING ASSEMBLY FOR POWER APPLICATIONS AND A METHOD OF MANUFACTURING SUCH ASSEMBLY

      
Application Number EP2023084293
Publication Number 2024/121127
Status In Force
Filing Date 2023-12-05
Publication Date 2024-06-13
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Zhao, Hongbo
  • Yan, Zhixing
  • Luan, Shaokang
  • Aunsborg, Thore Stig
  • Munk-Nielsen, Stig

Abstract

The present invention concerns a planar winding assembly for power applications, said assembly comprising a frame accommodating a stack of a plurality of printed circuit boards (PCBs), each comprising at least one conductive winding on the PCB, wherein the stack comprises an uppermost first PCB comprising an electrically insulating layer having a top surface and a bottom surface, where the bottom surface is provided with a conductive winding having a first winding pattern; at least one second PCB comprising an electrically insulating layer having a top surface and a bottom surface with conductive windings thereon, where the top surface is provided with the first winding pattern and the bottom surface is provided with a second winding pattern corresponding to the first winding pattern; a lowermost first PCB, which is similar to the uppermost first PCB but positioned with the winding facing upwards; means for holding the plurality of PCBs tightly against each other in the stacked configuration, and the frame encompasses the stack of PCBs. The invention further concerns a method of manufacturing a planar winding assembly for high-power applications.

IPC Classes  ?

  • H01F 17/00 - Fixed inductances of the signal type
  • H01F 17/04 - Fixed inductances of the signal type with magnetic core
  • H01F 27/28 - Coils; Windings; Conductive connections
  • H01F 27/30 - Fastening or clamping coils, windings, or parts thereof together; Fastening or mounting coils or windings on core, casing, or other support

5.

INHIBITORY NUCLEIC ACIDS AND METHODS OF USE THEREOF

      
Application Number US2023080512
Publication Number 2024/112653
Status In Force
Filing Date 2023-11-20
Publication Date 2024-05-30
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Nããr, Anders Michael
  • Gilroy, Caslin
  • Xu, Lei
  • Kauppinen, Sakari
  • Løvendorf, Marianne Bengtson
  • Petri, Andreas

Abstract

The present disclosure provides inhibitory nucleic acids, compositions comprising the inhibitory nucleic acids, and methods of using the inhibitory nucleic acids to treat various disorders.

IPC Classes  ?

  • A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
  • A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
  • A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

6.

REDUCING PARASITIC CAPACITANCE IN MEDIUM-VOLTAGE INDUCTORS

      
Application Number 18551690
Status Pending
Filing Date 2022-03-18
First Publication Date 2024-05-23
Owner Aalborg Universitet (Denmark)
Inventor
  • Zhao, Hongbo
  • Munk-Nielsen, Stig

Abstract

The present invention relates to inter alia to a conductor having at least two windings where each of the two windings preferably has layered configuration of turns, where each layer of a winding preferably is serially connected. Further, layers are typically distanced from each other, preferably by use of layer spacers, which preferably provide a void, or a number of voids, in between each layers. Conductors according to the present invention have shown to lessen, such as reducing parasitic capacitance.

IPC Classes  ?

  • H01F 27/34 - Special means for preventing or reducing unwanted electric or magnetic effects, e.g. no-load losses, reactive currents, harmonics, oscillations, leakage fields
  • H01F 1/153 - Amorphous metallic alloys, e.g. glassy metals
  • H01F 5/06 - Insulation of windings
  • H01F 27/00 - MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES - Details of transformers or inductances, in general
  • H01F 27/32 - Insulating of coils, windings, or parts thereof

7.

Antisense Oligonucleotides Targeting SARS-CoV-2

      
Application Number 18157063
Status Pending
Filing Date 2023-01-19
First Publication Date 2024-03-28
Owner
  • The Regents of the University of California (USA)
  • Aalborg University (Denmark)
Inventor
  • Naar, Anders Michael
  • Zhu, Chi
  • Kauppinen, Sakari
  • Karstensen, Kasper Thystrup

Abstract

COVID-19 is treated with antisense oligonucleotides (ASOs) targeting SARS-CoV-2 viral RNAs or human ACE2 RNA.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61P 31/14 - Antivirals for RNA viruses

8.

EXPLAINABLE DEEP LEARNING METHOD FOR NON-INVASIVE DETECTION OF PULMONARY HYPERTENSION FROM HEART SOUNDS

      
Application Number IB2023058675
Publication Number 2024/047610
Status In Force
Filing Date 2023-09-01
Publication Date 2024-03-07
Owner
  • INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIÊNCIA (Portugal)
  • UNIVERSIDADE DO PORTO (Portugal)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Gaudio, Alex
  • Renna, Francesco
  • Schmidt, Samuel
  • Tavares Coimbra, Miguel

Abstract

The present document discloses a computer-implemented method for non-invasive estimation of Pulmonary Hypertension, PH, from heart sound signals, comprising the steps: receiving a sound signal acquired from a beating heart of a subject over a predetermined time period; generating one or more 2D feature maps comprising a 2D feature map with the received sound signal where a first axis of the map is arranged over time and a second axis of the map is arranged over individual heartbeats; applying a pre-trained neural network to relate the generated one or more 2D feature maps with a training dataset of previously acquired and generated training 2D feature maps of a PH subject group and a non-PH subject group, thus to obtain an indicator of the presence of Pulmonary Hypertension. It further discloses a training method of said neural network and a system.

IPC Classes  ?

  • A61B 7/04 - Electric stethoscopes
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 8/02 - Measuring pulse or heart rate
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets

9.

A PLANNING METHOD FOR PROCESSING AN ELEMENT INTO A FINAL ELEMENT

      
Application Number 18003836
Status Pending
Filing Date 2021-07-02
First Publication Date 2024-01-25
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kristiansen, Morten
  • Kristiansen, Ewa
  • Thomsen, Anders Noel
  • Endelt, Benny Ørtoft
  • Mikkelstrup, Anders Faarbaek
  • Nikolov, Georgi Nikolaev

Abstract

The present invention relates to a computer-implemented method for planning laser processing of one or more elements into one or more final elements, such as planning a process of creating a final element from a sheet metal by creating a 5 model of both the sheet metal to be processed and the final element and determining a plurality of processing steps to create said final element. The method is based on a plurality of rules for taking into account, how to process the element by a plurality of processing steps, said processing steps comprising laser process specifications and generating at least a first set of instructions for an 10 associated laser processing device.

IPC Classes  ?

  • G05B 19/4097 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM

10.

A DEVICE AND A METHOD FOR SENSING VIBRATIONS IN A HUMAN'S SKIN EMANATING FROM BLOOD FLOW BELOW THE SKIN

      
Application Number EP2023061618
Publication Number 2023/213848
Status In Force
Filing Date 2023-05-03
Publication Date 2023-11-09
Owner
  • AALBORG UNIVERSITET (Denmark)
  • REGION NORDJYLLAND (Denmark)
Inventor
  • Schmidt, Samuel Emil
  • Damsgaard, Oliver Thomsen
  • Christensen, Jeppe Hagstrup

Abstract

The present invention relates to a device (1) and a method for sensing vibrations in a human's skin (2) emanating from blood flowing in a natural or artificial blood vessel or an arteriovenous fistula (AVF) (3) located below the skin. The device comprises a sensor (4), a controller (5), a transmitter (6), and an electrical power source (7). In particular, the invention relates to such a device that is configured to be fastened to the human and carried around by the human during use of the device. The measured signals are analysed, and if the blood flow is below a pre- selected blood flow threshold, an alarm signal is issued to warn e.g. a responsible medical doctor that there is a need for further assessment.

IPC Classes  ?

  • A61B 7/04 - Electric stethoscopes
  • A61B 7/00 - Instruments for auscultation
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/026 - Measuring blood flow
  • A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography

11.

METHOD OF MANUFACTURING A FIBRE REINFORCED COMPOSITE COMPONENT HAVING A REINFORCED HOLE

      
Application Number 18025793
Status Pending
Filing Date 2021-09-13
First Publication Date 2023-10-19
Owner Aalborg Universitet (Denmark)
Inventor
  • Endelt, Benny Ørtoft
  • Jakobsen, Johnny

Abstract

The invention relates to a method of manufacturing a composite component with continuous fibre reinforcement and having a reinforced hole. The hole is reinforced by incorporation of at least one reinforcing element (1) into a layered arrangement of continuous fibres. The reinforcing element comprises a circumferential member (2) with a through-going first hole (9) and a plurality of continuous element fibres (3). The at least one reinforcing element (1) is arranged in an overlapping and/or sandwiching engagement with the layered arrangement so that the first hole is arranged within and aligned with a second hole (8) to be reinforced. Hereby an externally force applied to the reinforced hole during use of the component is distributed over a larger region of the material around the hole. Thereby the component can be joined to another part e.g. by a bolted connection which allows for disassembly that would not have been possible if they were joined by adhesive joining.

IPC Classes  ?

  • B29C 70/68 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers
  • B29C 70/70 - Completely encapsulating inserts

12.

CONCRETE SCREW PILE

      
Application Number EP2023057159
Publication Number 2023/180293
Status In Force
Filing Date 2023-03-21
Publication Date 2023-09-28
Owner
  • AALBORG UNIVERSITET (Denmark)
  • ANDREASEN & HVIDBERG A/S (Denmark)
  • BAYO.S SKRUEFUNDAMENTER APS (Denmark)
Inventor
  • Ibsen, Lars Bo
  • Porsmose, Jens Jacob
  • Madsen, Niels
  • Ibsen, Mikkel
  • Tvede, Jacob

Abstract

The invention relates to a screw pile (100) adapted for being installed in the ground for providing foundation for a construction (800) or a like, said screw pile comprising an elongated body (200), wherein at least one of the upper part (210), middle part (220) or lower part (230) of the elongated body comprises one or more threaded portions (300), and wherein at least a portion of the volume of the screw pile is concrete (400), said portion of concrete being 50% or more of the volume of the screw pile. In some embodiments, only the lower part of the screw pile has a threaded portion and is made of metal, while an elongated shaft is made of at least 70% concrete. Furthermore, the invention relates to a method of manufacturing a screw pile, said method comprising at least the steps of: providing a mold (600), providing a wet concrete mixture (700) in a liquid form, optionally, providing reinforcement (500), preferably being bars, wires or spirals, optionally, inserting the reinforcement into the concrete mixture, filling the mold with the concrete mixture.

IPC Classes  ?

  • E02D 5/24 - Prefabricated piles
  • E02D 5/30 - Prefabricated piles made of concrete or reinforced concrete or made of steel and concrete
  • E02D 5/56 - Screw piles
  • E02D 7/22 - Placing by screwing down

13.

METHOD AND SYSTEM FOR INSTALLING OF A SCREW PILE IN A SOIL

      
Application Number EP2023057162
Publication Number 2023/180295
Status In Force
Filing Date 2023-03-21
Publication Date 2023-09-28
Owner
  • AALBORG UNIVERSITET (Denmark)
  • BAYO.S SKRUEFUNDAMENTER APS (Denmark)
  • ANDREASEN & HVIDBERG A/S (Denmark)
Inventor
  • Ibsen, Lars Bo
  • Ibsen, Mikkel
  • Porsmose, Jens Jacob
  • Madsen, Niels
  • Tvede, Jacob

Abstract

The present invention relates to a method for installation and validation of a screw pile (100) being installed in the ground, said method comprising the steps of: placing at least one screw pile at a location, providing means for screwing (200) the at least one screw pile into the ground, starting screwing the at least one screw pile into the ground by the means for screwing, during the process of screwing measuring at least a set of installation parameters comprising: torsion and/or torque and penetration depth, generating an output indicative of said installation parameters, and providing an installation validation, e.g. an installation validation document or file, of the at least one screw pile. In some embodiments the method comprises to stop screwing the screw pile into the ground when predetermined thresholds of installation parameters are reached. In some embodiments the method comprises generating a data on how the screw pile was installed, e.g. screw direction and rotation versus penetration depth data, e.g. to be included as part of the installation validation. Furthermore, the present invention relates to an installation validation document for at least one screw pile installed in the ground, moreover the invention relates to a computer program.

IPC Classes  ?

14.

MODULAR POWER CONVERTER

      
Application Number DK2023050044
Publication Number 2023/179830
Status In Force
Filing Date 2023-03-17
Publication Date 2023-09-28
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Munk-Nielsen, Stig
  • Ahmad, Faheem
  • Beczkowski, Szymon Michal
  • Jørgensen, Asger Bjørn
  • Uhrenfeldt, Christian

Abstract

The present invention provides a power module arranged to receive a DC electric input signal at first and second connection terminals (A, B), and to output an AC electric output signal at third and fourth connection terminals (C, D). A set of capacitors (CAP1, CAP2) are connected between respective sets of connection terminals (A, B, C, D). Two inductors (L1, L2) are connected at least to respective connection terminals (C, D), such as the first inductor (L1) being connected between on set of connection terminals (A, C), and the second inductor (L2) being connected between another set of connection terminals (B, D). A switch network (SWN) with at least one electrically controllable bidirectional two-quadrant switch (s1), is connected between at least two of the four connection terminals (A, B, C, D). The at least one witch (s1) is arranged for being controlled according to a switching cycle, so as to provide an average voltage (V1) of zero across the first inductor (L1) over one switching period of the switching cycle, and to provide an average voltage (V2) of zero across the second inductor (L2) over one switching period. The power module is simple, and can be implemented with only one single switch per module. A DC to AC power converter can be build of a number of interconnected power modules, and such power converter can be designed to provide an AC output voltage in the kV range at a power in the kW range, at a frequency of up to such as 40 MHz.

IPC Classes  ?

  • H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
  • H02M 7/48 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
  • H05B 6/48 - Circuits
  • H02M 7/49 - Combination of the output voltage waveforms of a plurality of converters
  • H02M 7/483 - Converters with outputs that each can have more than two voltage levels
  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

15.

APPARATUS AND METHOD FOR TESTING THE LOAD BEARING CAPACITY OF A FOUNDATION PILE

      
Application Number EP2023057166
Publication Number 2023/180297
Status In Force
Filing Date 2023-03-21
Publication Date 2023-09-28
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Ibsen, Lars Bo
  • Sabaliauskas, Tomas
  • Borup, Kim

Abstract

The invention relates to a load-bearing test apparatus adapted to test the load-bearing capacity of an associated pile installed in the ground, preferably an associated screw pile, the load-bearing test apparatus comprising: a load carrier having at least one main protrusion and at least one receiving portion, a load being positioned on the load carrier or being an integrated part of the carrier, preferably being a plurality of load plates, a shaft adapted for allowing the load carrier to slide up and down in a vertical direction, at least one connecting piece for attachable connecting the load carrier to the associated pile, and a locking system. Furthermore, the invention relates to a method for testing the load-bearing capacity of a pile installed in the ground.

IPC Classes  ?

16.

A METHOD FOR PROCESSING ELEMENTS INTO FINAL ELEMENTS

      
Application Number 18003824
Status Pending
Filing Date 2021-07-02
First Publication Date 2023-08-24
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kristiansen, Morten
  • Kristiansen, Ewa
  • Endelt, Benny Ørtoft
  • Villumsen, Sigurd Lazic
  • Thomsen, Anders Noel
  • Mikkelstrup, Anders Faarbaek

Abstract

The present invention relates to method for cutting and shaping and/or bending a metal element into a final element using laser means, the method comprising providing data containing a final model of the final element and providing a set of instructions as to how to process the final element from the metal element, measure the processing and provide at least a second set of instructions based on feedback, such as geometrical measurements during said processing, so as to create a final element.

IPC Classes  ?

  • G05B 19/18 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form

17.

METHOD FOR CONTROLLING AN ORTHOPEDIC DEVICE AND ORTHOPEDIC DEVICE

      
Application Number 18006288
Status Pending
Filing Date 2020-07-21
First Publication Date 2023-08-17
Owner
  • OTTOBOCK SE & CO. KGAA (Germany)
  • UNIVERSITEIT TWENTE (Netherlands)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Gonzalez Vargas, Jose
  • Frerk, Eileen
  • Durandau, Guillaume
  • Dosen, Strahinja

Abstract

The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: —Providing input signals, —Using said input signals as input variables of a musculoskeletal model, —Determining feedback signals using said musculoskeletal model, —Transmitting said feedback signals to said user of said orthopedic device.

IPC Classes  ?

  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

18.

ENERGY HARVESTER BASED ON PIEZOELECTRIC IMPACT COMPARTMENT

      
Application Number DK2023050010
Publication Number 2023/138743
Status In Force
Filing Date 2023-01-19
Publication Date 2023-07-27
Owner
  • AALBORG UNIVERSITET (Denmark)
  • REGION NORDJYLLAND (Denmark)
Inventor
  • Rezaniakolaei, Alireza
  • Riahi, Sam
  • Enkeshafi, Ali Asghar
  • Khazaee, Majid
  • Rosendahl, Lasse Aistrup

Abstract

Disclosed is an energy harvester for generating electric energy from an external vibratory force, such as a vibratory force caused by movement of a part of a living human or animal. The energy harvester has a compartment (CMP1, CMP2) with wall element(s) forming a cavity inside. At least one wall element of the compartment has a piezoelectric element connected to an electric output terminal. An impact object (BL) is positioned inside the cavity of the compartment. The impact object is configured to move inside the cavity and to generate an impact on a surface of the wall element(s), so as to cause the piezoelectric element to generate an electric output on the electric output terminal. The compartment may have a cubic shape, e.g. made of a single piezoelectric element folded into shape, e.g. a two-layer piezoelectric element. The impact object may be a metal or ceramics object with a spherical shape. Especially, the energy harvester may be used to power an implantable medical device, e.g. an intra-cardiac pacemaker. An energy harvester housing within an intra-cardiac pacemaker has been tested to be sufficient for powering the pacemaker stimulation circuit by the vibratory force caused by heartbeats.

IPC Classes  ?

  • H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
  • A61N 1/378 - Electrical supply

19.

PROCESS TO PRODUCE A GLASS-BASED ARTICLE AND GLASS-BASED ARTICLES

      
Application Number EP2022086278
Publication Number 2023/126209
Status In Force
Filing Date 2022-12-16
Publication Date 2023-07-06
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Smedskjær, Morten Mattrup
  • Christensen, Rasmus
  • To, Theany

Abstract

The present invention relates to glass-based substrates and articles that can be hydrated under special circumstances to increase their crack resistance and induce self-healing, and to processes for their production.

IPC Classes  ?

  • C03C 3/083 - Glass compositions containing silica with 40% to 90% silica by weight containing aluminium oxide or an iron compound
  • C03C 3/085 - Glass compositions containing silica with 40% to 90% silica by weight containing aluminium oxide or an iron compound containing an oxide of a divalent metal
  • C03C 3/091 - Glass compositions containing silica with 40% to 90% silica by weight containing boron containing aluminium
  • C03C 23/00 - Other surface treatment of glass not in the form of fibres or filaments
  • C03C 21/00 - Treatment of glass, not in the form of fibres or filaments, by diffusing ions or metals into the surface

20.

A HYDRAULIC DEVICE

      
Application Number DK2022050249
Publication Number 2023/093961
Status In Force
Filing Date 2022-11-28
Publication Date 2023-06-01
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Johansen, Per
  • Hansen, Anders Hedegaard

Abstract

The present invention relates inter alia to a hydraulic device which may be used as a hydraulic transformer. The hydraulic device comprising a housing, a first tubular cavity and a second tubular cavity both being provided within the housing. A piston structure is reciprocatable arranged within the housing and comprises a first piston and a second piston; wherein the first piston divides the first cavity into two chambers, and the second piston divides the second cavity into two chambers. Fluid passages for individually exchanging fluid between the chambers and the exterior of the housing are provided and each fluid passage comprising a controllable shut-off valve so as to provide the reciprocating movement of the piston structure by exchanging fluid between exterior and the two chambers of the first cavity, and said hydraulic transformed being configured to control the shut-off valves to selectively be in a closed state or in an open state.

IPC Classes  ?

  • F15B 3/00 - Intensifiers or fluid-pressure converters, e.g. pressure exchangers; Conveying pressure from one fluid system to another, without contact between the fluids
  • F15B 11/032 - Systems essentially incorporating special features for controlling the speed or the actuating force or speed of an output member for controlling the actuating force by means of fluid-pressure converters
  • F04F 13/00 - Pressure exchangers
  • F15B 11/036 - Systems essentially incorporating special features for controlling the speed or the actuating force or speed of an output member for controlling the actuating force by means of servomotors having a plurality of working chambers

21.

Non-invasive front-end for power electronic monitoring

      
Application Number 17918141
Grant Number 12158490
Status In Force
Filing Date 2021-04-13
First Publication Date 2023-05-04
Grant Date 2024-12-03
Owner Aalborg Universitet (Denmark)
Inventor
  • Wang, Huai
  • Peng, Yingzhou

Abstract

A front-end device for monitoring operation of an associated electric power device with semiconductor power switches generating a power output, e.g. a three-phase power output. The front-end device has input terminals arranged for connection to the electric phase(s) of the power output of the associated electric power device, and an electric circuit connected to the input terminals and connected to at set of output terminals. The electric circuit has a passive interconnection comprising electric semiconductor switches and diodes. The electric circuit serves to electrically block any high voltage component from the input terminals from reaching the output terminals, while allowing an on-state voltage of at least one semiconductor power switch in the associated electric power device to pass to the at least two output terminals. The front-end allows low voltage equipment to be connected to its output terminals for determining an on-state voltage of switches of the electric power device. Especially, embodiments with self-powered reference voltage circuits provided by zener diodes allow compact low cost versions for use in e.g. portable test equipment or as part of permanently installed health condition monitoring of power devices. The front-end device can be used as a simple and low cost solution for non-invasive health condition monitoring of power devices, e.g. power converters in such as power electric generation system or electric vehicles. Such monitoring allows predictive maintenance to be performed to avoid any faults in the power device that may cause permanent damages.

IPC Classes  ?

  • G01R 31/26 - Testing of individual semiconductor devices
  • G01R 31/327 - Testing of circuit interrupters, switches or circuit-breakers

22.

NON-INVASIVE TONGUE BASED INTERFACE

      
Application Number DK2022050196
Publication Number 2023/046252
Status In Force
Filing Date 2022-09-23
Publication Date 2023-03-30
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Struijk, Lotte Najanguaq Søvsø Andreasen
  • Bentsen, Bo

Abstract

The invention provides a non-invasive tongue based with a tongue sensor device arranged for position in the oral cavity of the user. A sensor panel to be placed on an upper part of the oral cavity of the user, and having a 2D array of activation zones and related electric coils. A guide structure, e.g. a metal or polymer frame, carries a ferrous or metallic activation unit movably in a plane upon manipulation by the user's tongue. This allows the user to position the activation unit in relation the activation zones. The guide structure allows the activation unit to move also perpendicular to the plane, to allow the user's tongue to manipulate the activation unit near one activation zone for activation of the activation zone. An electronic circuit inductively senses activation of any one or more of the plurality of activation zones and related electric coils and generates an output accordingly, e.g. a wireless RF output. E.g. a frame structure of metal wires or bars can be used to implement the guide structure, thus allowing the activation unit, e.g. a metal sphere or cylinder, to form an integrated part of the rather than being mounted in an invasive way on the user's tongue.

IPC Classes  ?

  • A61F 4/00 - Methods or devices enabling patients or disabled persons to operate an apparatus or a device not forming part of the body
  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

23.

ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS

      
Application Number 16322000
Status Pending
Filing Date 2017-08-03
First Publication Date 2022-11-10
Owner Aalborg Universitet (Denmark)
Inventor
  • Kauppinen, Sakari
  • Petri, Andreas
  • Albæk Thrue, Charlotte

Abstract

The present invention provides antisense oligonucleotides directed against immune checkpoints and methods and compositions of using such antisense oligonucleotides for the treatment of cancer.

IPC Classes  ?

  • A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
  • C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61P 35/00 - Antineoplastic agents

24.

SOFT ACTIVE HAND ORTHOSIS

      
Application Number 17620337
Status Pending
Filing Date 2020-06-23
First Publication Date 2022-10-13
Owner Aalborg Universitet (Denmark)
Inventor
  • Abdelhafiz, Mohamed
  • Struijk, Lotte Najanguaq Søvsø Adreasen
  • Dosen, Strahinja
  • Spaich, Erika Geraldina

Abstract

The invention relates to a hand orthosis (1) for assisting the movements of a user's hand. The hand orthosis comprises a soft glove (2) adapted to receive at least a part of the user's hand with finger sections of the glove receiving each of the user's fingers. It further comprises at least one actuator box (3), and a power transmission (4) for transferring forces from the at least one actuator box to different parts of the glove via exo-tendons (5). The exo-tendons are arranged on a dorsal side, on a palmar side, or on both a dorsal side and a palmar side of the glove. The exo-tendons are arranged so that the glove can assist flexion, extension, or both extension and flexion of the fingers, respectively and so that the exo-tendons act on the fingers to produce motion that mimics the movement of a human hand. The hand orthosis provides different grasp types, self- adaptation of the fingers' motion to the shape of the object, and physiologically appropriate distribution of finger forces.

IPC Classes  ?

  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

25.

REDUCING PARASITIC CAPACITANCE IN MEDIUM-VOLTAGE INDUCTORS

      
Application Number DK2022050053
Publication Number 2022/199768
Status In Force
Filing Date 2022-03-18
Publication Date 2022-09-29
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Zhao, Hongbo
  • Munk-Nielsen, Stig

Abstract

The present invention relates to inter alia to a conductor having at least two windings where each of the two windings preferably has layered configuration of turns, where each layer of a winding preferably is serially connected. Further, layers are typically distanced from each other, preferably by use of layer spacers, which preferably provide a void, or a number of voids, in between each layers. Conductors according to the present invention have shown to lessen, such as reducing parasitic capacitance.

IPC Classes  ?

  • H01F 37/00 - Fixed inductances not covered by group
  • H01F 5/02 - Coils wound on non-magnetic supports, e.g. formers
  • H01F 17/06 - Fixed inductances of the signal type with magnetic core with core substantially closed in itself, e.g. toroid
  • H01F 27/28 - Coils; Windings; Conductive connections
  • H01F 27/29 - Terminals; Tapping arrangements
  • H01F 27/32 - Insulating of coils, windings, or parts thereof

26.

MULTIPARAMETERIC ESTIMATION OF CARDIORESPIRATORY FITNESS IN SEISMOCARDIOGRAPHY

      
Application Number 17596036
Status Pending
Filing Date 2020-06-05
First Publication Date 2022-09-22
Owner AALBORG UNIVERSITET (Denmark)
Inventor Schmidt, Samuel Emil

Abstract

The proposed technology relates to the quantifying of cardiorespiratory fitness. It includes the obtaining (102) of a seismocardiogram (SCG) recorded with an accelerometer (14) configured to measure accelerations and vibrations of the chest wall of a person (18) caused by myocardial movement. Properties of a first signal feature (AC) in the seismocardiogram (SCG) are determined (104), wherein the first signal feature (AC) corresponds to the aortic valve closure (AC) of a heartbeat. A measure indicating cardiorespiratory fitness (VO2 max) is then determined (106) based on the properties of first signal feature (AC).

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/024 - Measuring pulse rate or heart rate

27.

BIOMARKERS FOR PULMONARY EMBOLISM IN EXHALED BREATH CONDENSATE

      
Application Number 17615693
Status Pending
Filing Date 2020-06-03
First Publication Date 2022-07-28
Owner
  • Region Nordjylland, Aalborg University Hospital (Denmark)
  • Aarhus Universitet (Denmark)
  • Aalborg Universitet (Denmark)
Inventor
  • Gade, Inger Lise
  • Honoré, Bent
  • Kristensen, Søren Risom

Abstract

A method is provided for determining pulmonary embolism and/or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

28.

Therapeutic Targeting of a microRNA to Treat Duchenne Muscular Dystrophy

      
Application Number 17557415
Status Pending
Filing Date 2021-12-21
First Publication Date 2022-07-07
Owner
  • The General Hospital Corporation (USA)
  • Aalborg University (Denmark)
Inventor
  • Naar, Anders M.
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

29.

Identification and Quantification of A Ventilatory Disturbance Causing Incorrect Measurement Of Arterial Acid-Base Status

      
Application Number 17601104
Status Pending
Filing Date 2020-04-06
First Publication Date 2022-06-30
Owner
  • OBI APS (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Graversen, Bruno
  • Shastri, Lisha
  • Thomsen, Lars Pilegaard
  • Rees, Stephen Edward

Abstract

The present invention relates to a computer-implemented method for identification of the degree to which a transient disturbance in ventilation causes changes in measurement of arterial acid-base status.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value

30.

SPHERICAL MECHANISM CONSTRUCTED WITH SCISSORS LINKAGES WITH CONTROL MEANS

      
Application Number 17604174
Status Pending
Filing Date 2020-04-23
First Publication Date 2022-06-23
Owner Aalborg Universitet (Denmark)
Inventor
  • Castro, Miguel Nobre
  • Rasmussen, John
  • Andersen, Michael Skipper

Abstract

The invention relates to a curved spherical scissors linkage mechanism (1) comprising at least four linkage elements (2) each having a first end (3) and a second end (4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombi or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion (RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The spherical scissors linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end. It further comprises actuator means as control means.

IPC Classes  ?

  • B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
  • B25J 9/00 - Programme-controlled manipulators
  • A61H 1/02 - Stretching or bending apparatus for exercising

31.

IDENTIFICATION AND QUANTIFICATION OF THE DEGREE OF TISSUE HYPOXIA

      
Application Number 17600620
Status Pending
Filing Date 2020-04-06
First Publication Date 2022-06-09
Owner
  • OBI APS (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Graversen, Bruno
  • Shastri, Lisha
  • Thomsen, Lars Pilegaard
  • Rees, Stephen Edward

Abstract

The present invention relates to a method for identification of tissue hypoxia from measurements of acid-base and oxygenation status from venous and/or arterial blood.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

32.

METHOD OF MANUFACTURING A FIBRE REINFORCED COMPOSITE COMPONENT HAVING A REINFORCED HOLE

      
Application Number DK2021050280
Publication Number 2022/053120
Status In Force
Filing Date 2021-09-13
Publication Date 2022-03-17
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Endelt, Benny Ørtoft
  • Jakobsen, Johnny

Abstract

The invention relates to a method of manufacturing a composite component with continuous fibre reinforcement and having a reinforced hole. The hole is reinforced by incorporation of at least one reinforcing element (1) into a layered arrangement of continuous fibres. The reinforcing element comprises a circumferential member (2) with a through-going first hole (9) and a plurality of continuous element fibres (3). The at least one reinforcing element (1) is arranged in an overlapping and/or sandwiching engagement with the layered arrangement so that the first hole is arranged within and aligned with a second hole (8) to be reinforced. Hereby an externally force applied to the reinforced hole during use of the component is distributed over a larger region of the material around the hole. Thereby the component can be joined to another part e.g. by a bolted connection which allows for disassembly that would not have been possible if they were joined by adhesive joining.

IPC Classes  ?

  • B29C 70/20 - Fibrous reinforcements only characterised by the structure of fibrous reinforcements using fibres of substantial or continuous length oriented in a single direction, e.g. roving or other parallel fibres
  • B29C 70/30 - Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core
  • B29C 70/76 - Moulding on edges or extremities of the preformed part
  • B29C 70/84 - Moulding material on preformed parts to be joined
  • B29C 70/86 - Incorporating in coherent impregnated reinforcing layers
  • B29C 70/32 - Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core on a rotating mould, former or core
  • B29C 70/38 - Automated lay-up, e.g. using robots, laying filaments according to predetermined patterns

33.

ANTISENSE OLIGONUCLEOTIDES TARGETING SARS-COV-2

      
Application Number US2021041503
Publication Number 2022/031410
Status In Force
Filing Date 2021-07-13
Publication Date 2022-02-10
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Naar, Anders, Michael
  • Kauppinen, Sakari
  • Zhu, Chi
  • Karstensen, Kasper, Thystrup

Abstract

COVID-19 is treated with antisense oligonucleotides (ASOs) targeting SARS-CoV-2 viral RNAs or human ACE2 RNA.

IPC Classes  ?

  • A61K 35/76 - Viruses; Subviral particles; Bacteriophages
  • A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
  • C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
  • C12N 15/86 - Viral vectors

34.

METHOD FOR CONTROLLING AN ORTHOPEDIC DEVICE AND ORTHOPEDIC DEVICE

      
Application Number EP2020070539
Publication Number 2022/017583
Status In Force
Filing Date 2020-07-21
Publication Date 2022-01-27
Owner
  • OTTOBOCK SE & CO. KGAA (Germany)
  • UNIVERSITEIT TWENTE (Netherlands)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Gonzales Vargas, Jose
  • Frerk, Eileen
  • Durandau, Guillaume
  • Dosen, Strahinja
  • Sartori, Massimo

Abstract

The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: - Providing input signals, - Using said input signals as input variables of a musculoskeletal model, - Determining feedback signals using said musculoskeletal model, - Transmitting said feedback signals to said user of said orthopedic device.

IPC Classes  ?

  • A61F 2/54 - Artificial arms or hands or parts thereof
  • A61F 2/60 - Artificial legs or feet or parts thereof
  • A61F 2/72 - Bioelectric control, e.g. myoelectric
  • A61F 2/50 - Prostheses not implantable in the body
  • A61F 2/68 - Operating or control means

35.

A METHOD FOR PROCESSING ELEMENTS INTO FINAL ELEMENTS

      
Application Number DK2021050222
Publication Number 2022/002338
Status In Force
Filing Date 2021-07-02
Publication Date 2022-01-06
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kristiansen, Morten
  • Kristiansen, Ewa
  • Endelt, Benny Ørtoft
  • Villumsen, Sigurd Lazic
  • Thomsen, Anders Noel
  • Mikkelstrup, Anders Faarbæk

Abstract

The present invention relates to method for cutting and shaping and/or bending a metal element into a final element using laser means, the method comprising providing data containing a final model of the final element and providing a set of instructions as to how to process the final element from the metal element, measure the processing and provide at least a second set of instructions based on feedback, such as geometrical measurements during said processing, so as to create a final element.

IPC Classes  ?

  • G05B 19/4097 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM

36.

A PLANNING METHOD FOR PROCESSING AN ELEMENT INTO A FINAL ELEMENT

      
Application Number DK2021050223
Publication Number 2022/002339
Status In Force
Filing Date 2021-07-02
Publication Date 2022-01-06
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kristiansen, Morten
  • Kristiansen, Ewa
  • Thomsen, Anders Noel
  • Endelt, Benny Ørtoft
  • Mikkelstrup, Anders Faarbæk
  • Nikolov, Georgi Nikolaev

Abstract

The present invention relates to a computer-implemented method for planning laser processing of one or more elements into one or more final elements, such as planning a process of creating a final element from a sheet metal by creating a 5 model of both the sheet metal to be processed and the final element and determining a plurality of processing steps to create said final element. The method is based on a plurality of rules for taking into account, how to process the element by a plurality of processing steps, said processing steps comprising laser process specifications and generating at least a first set of instructions for an 10 associated laser processing device.

IPC Classes  ?

  • G05B 19/4097 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM

37.

NON-INVASIVE FRONT-END FOR POWER ELECTRONIC MONITORING

      
Application Number DK2021050101
Publication Number 2021/209101
Status In Force
Filing Date 2021-04-13
Publication Date 2021-10-21
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Wang, Huai
  • Peng, Yingzhou

Abstract

A front-end device for monitoring operation of an associated electric power device with semiconductor power switches generating a power output, e.g. a three-phase power output. The front-end device has input terminals arranged for connection to the electric phase(s) of the power output of the associated electric power device, and an electric circuit connected to the input terminals and connected to at set of output terminals. The electric circuit has a passive interconnection comprising electric semiconductor switches and diodes. The electric circuit serves to electrically block any high voltage component from the input terminals from reaching the output terminals, while allowing an on-state voltage of at least one semiconductor power switch in the associated electric power device to pass to the at least two output terminals. The front-end allows low voltage equipment to be connected to its output terminals for determining an on-state voltage of switches of the electric power device. Especially, embodiments with self-powered reference voltage circuits provided by zener diodes allow compact low cost versions for use in e.g. portable test equipment or as part of permanently installed health condition monitoring of power devices. The front-end device can be used as a simple and low cost solution for non-invasive health condition monitoring of power devices, e.g. power converters in such as power electric generation system or electric vehicles. Such monitoring allows predictive maintenance to be performed to avoid any faults in the power device that may cause permanent damages.

IPC Classes  ?

  • G01R 31/26 - Testing of individual semiconductor devices
  • G01R 31/327 - Testing of circuit interrupters, switches or circuit-breakers
  • H03K 17/00 - Electronic switching or gating, i.e. not by contact-making and -breaking
  • H02M 1/32 - Means for protecting converters other than by automatic disconnection

38.

Power circuits for modular multi-level converters (MMC) and modular multi-level converters

      
Application Number 17052662
Grant Number 11228257
Status In Force
Filing Date 2019-04-10
First Publication Date 2021-08-05
Grant Date 2022-01-18
Owner Aalborg Universitet (USA)
Inventor Munk-Nielsen, Stig

Abstract

Existing modular multi-level converters can be bulky because their submodule capacitors are comparatively large. To address this shortcoming in the state of the art, the present disclosure provides electronic power circuits and their use in power converters and in modular multi-level converters. The disclosed power circuits include connection terminals connected to electrically controllable bidirectional two-quadrant switches and to capacitors, as well as inductors that are magnetically coupled and operate to equalize voltages of the capacitors.

IPC Classes  ?

  • H02M 7/483 - Converters with outputs that each can have more than two voltage levels
  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

39.

Two-terminal active inductor device

      
Application Number 16971772
Grant Number 11515067
Status In Force
Filing Date 2019-02-21
First Publication Date 2021-03-25
Grant Date 2022-11-29
Owner AALBORG UNIVERSITET (USA)
Inventor
  • Wang, Huai
  • Wang, Haoran

Abstract

An active two-terminal inductor device with a controllable inducitance based on an inductance value input L_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value inductor component L1. Based on sampling of at least a voltage or a current in connection with the inductor component L1, the algorithm controls the power converter PCV to provide a resulting inductance across the external terminals A, B which serves to match the inductance value input L_I.

IPC Classes  ?

  • H01F 7/06 - Electromagnets; Actuators including electromagnets
  • H01F 7/20 - Electromagnets; Actuators including electromagnets without armatures
  • H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

40.

Inhibitors of micro-RNA 22

      
Application Number 16979782
Grant Number 11499152
Status In Force
Filing Date 2019-03-14
First Publication Date 2021-01-21
Grant Date 2022-11-15
Owner
  • Beth Israel Deaconess Medical Center (USA)
  • Aalborg University (Denmark)
Inventor
  • Pandolfi, Pier Paolo
  • Panella, Riccardo
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

IPC Classes  ?

  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

41.

SOFT ACTIVE HAND ORTHOSIS

      
Application Number DK2020050185
Publication Number 2020/259776
Status In Force
Filing Date 2020-06-23
Publication Date 2020-12-30
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Abdelhafiz, Mohamed
  • Struijk, Lotte Najanguaq Søvsø Andreasen
  • Dosen, Strahinja
  • Spaich, Erika Geraldina

Abstract

The invention relates to a hand orthosis (1) for assisting the movements of a user's hand. The hand orthosis comprises a soft glove (2) adapted to receive at least a part of the user's hand with finger sections of the glove receiving each of the user's fingers. It further comprises at least one actuator box (3), and a power transmission (4) for transferring forces from the at least one actuator box to different parts of the glove via exo-tendons (5). The exo-tendons are arranged on a dorsal side, on a palmar side, or on both a dorsal side and a palmar side of the glove. The exo-tendons are arranged so that the glove can assist flexion, extension, or both extension and flexion of the fingers, respectively and so that the exo-tendons act on the fingers to produce motion that mimics the movement of a human hand. The hand orthosis provides different grasp types, self- adaptation of the fingers' motion to the shape of the object, and physiologically appropriate distribution of finger forces.

IPC Classes  ?

  • A61F 2/58 - Elbows; Wrists
  • A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

42.

Two-terminal active capacitor device

      
Application Number 16971710
Grant Number 11245331
Status In Force
Filing Date 2019-02-21
First Publication Date 2020-12-17
Grant Date 2022-02-08
Owner Aalborg Universitet (USA)
Inventor
  • Wang, Huai
  • Wang, Haoran
  • Blaabjerg, Frede

Abstract

An active two-terminal capacitor device with a controllable capacitance based on a capacitance value input C_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value capacitor component CI. Based on sampling of at least the voltage across the capacitor component CI, the algorithm controls the power converter PCV to provide a resulting capacitance across the external terminals A, B which serves to match the capacitance value in ut C_I.

IPC Classes  ?

  • H02M 3/158 - Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
  • G06F 1/26 - Power supply means, e.g. regulation thereof
  • H02M 7/00 - Conversion of ac power input into dc power output; Conversion of dc power input into ac power output
  • H02M 7/5387 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration

43.

MULTIPARAMETERIC ESTIMATION OF CARDIORESPIRATORY FITNESS IN SEISMOCARDIOGRAPHY

      
Document Number 03138830
Status Pending
Filing Date 2020-06-05
Open to Public Date 2020-12-10
Owner AALBORG UNIVERSITET (Denmark)
Inventor Schmidt, Samuel Emil

Abstract

The proposed technology relates to the quantifying of cardiorespiratory fitness. It includes the obtaining (102) of a seismocardiogram (SCG) recorded with an accelerometer (14) configured to measure accelerations and vibrations of the chest wall of a person (18) caused by myocardial movement. Properties of a first signal feature (AC) in the seismocardiogram (SCG) are determined (104), wherein the first signal feature (AC) corresponds to the aortic valve closure (AC) of a heartbeat. A measure indicating cardiorespiratory fitness (VO2max) is then determined (106) based on the properties of first signal feature (AC).

IPC Classes  ?

  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
  • A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

44.

BIOMARKERS FOR PULMONARY EMBOLISM IN EXHALED BREATH CONDENSATE

      
Application Number EP2020065352
Publication Number 2020/245200
Status In Force
Filing Date 2020-06-03
Publication Date 2020-12-10
Owner
  • REGION NORDJYLLAND, AALBORG UNIVERSITY HOSPITAL (Denmark)
  • AARHUS UNIVERSITET (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Gade, Inger, Lise
  • Honoré, Bent
  • Kristensen, Søren, Risom

Abstract

A method is provided for determining pulmonary embolism and/or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.

IPC Classes  ?

  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

45.

MULTIPARAMETERIC ESTIMATION OF CARDIORESPIRATORY FITNESS IN SEISMOCARDIOGRAPHY

      
Application Number EP2020065601
Publication Number 2020/245340
Status In Force
Filing Date 2020-06-05
Publication Date 2020-12-10
Owner AALBORG UNIVERSITET (Denmark)
Inventor Schmidt, Samuel Emil

Abstract

The proposed technology relates to the quantifying of cardiorespiratory fitness. It includes the obtaining (102) of a seismocardiogram (SCG) recorded with an accelerometer (14) configured to measure accelerations and vibrations of the chest wall of a person (18) caused by myocardial movement. Properties of a first signal feature (AC) in the seismocardiogram (SCG) are determined (104), wherein the first signal feature (AC) corresponds to the aortic valve closure (AC) of a heartbeat. A measure indicating cardiorespiratory fitness (VO2max) is then determined (106) based on the properties of first signal feature (AC).

IPC Classes  ?

  • G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
  • G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
  • G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

46.

Therapeutic targeting of a microRNA to treat Duchenne muscular dystrophy

      
Application Number 16828411
Grant Number 11236336
Status In Force
Filing Date 2020-03-24
First Publication Date 2020-11-19
Grant Date 2022-02-01
Owner
  • The General Hospital Corporation (USA)
  • Aalborg University (Denmark)
Inventor
  • Naar, Anders M.
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

47.

SPHERICAL MECHANISM CONSTRUCTED WITH SCISSORS LINKAGES WITH CONTROL MEANS

      
Application Number DK2020050110
Publication Number 2020/216425
Status In Force
Filing Date 2020-04-23
Publication Date 2020-10-29
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Castro, Miguel Nobre
  • Rasmussen, John
  • Andersen, Michael Skipper

Abstract

The invention relates to a curved spherical scissors linkage mechanism (1) comprising at least four linkage elements (2) each having a first end (3) and a second end (4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombus or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion (RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The spherical scissors linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end. It further comprises actuator means as control means.

IPC Classes  ?

  • B25J 9/00 - Programme-controlled manipulators
  • B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
  • B25J 18/00 - Arms

48.

IDENTIFICATION AND QUANTIFICATION OF THE DEGREE OF TISSUE HYPOXIA

      
Application Number EP2020059791
Publication Number 2020/207979
Status In Force
Filing Date 2020-04-06
Publication Date 2020-10-15
Owner
  • OBI APS (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Graversen, Bruno
  • Shastri, Lisha
  • Thomsen, Lars Pilegaard
  • Rees, Stephen Edward

Abstract

The present invention relates to a method for identification of tissue hypoxia from measurements of acid-base and oxygenation status from venous and/or arterial blood.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes

49.

IDENTIFICATION AND QUANTIFICATION OF A VENTILATORY DISTURBANCE CAUSING INCORRECT MEASUREMENT OF ARTERIAL ACID-BASE STATUS

      
Application Number EP2020059794
Publication Number 2020/207981
Status In Force
Filing Date 2020-04-06
Publication Date 2020-10-15
Owner
  • OBI APS (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Graversen, Bruno
  • Shastri, Lisha
  • Thomsen, Lars Pilegaard
  • Rees, Stephen Edward

Abstract

The present invention relates to a computer-implemented method for identification of the degree to which a transient disturbance in ventilation causes changes in measurement of arterial acid-base status.

IPC Classes  ?

  • A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes

50.

Compact spherical 3-DOF mechanism constructed with scissor linkages

      
Application Number 16756779
Grant Number 11890751
Status In Force
Filing Date 2018-10-17
First Publication Date 2020-07-30
Grant Date 2024-02-06
Owner Aalborg Universitet (Denmark)
Inventor
  • Castro, Miguel Nobre
  • Rasmussen, John
  • Andersen, Michael Skipper
  • Bai, Shaoping

Abstract

A curved scissor linkage mechanism (1) includes at least four linkage elements (2) each having a first end (3) and a second end (4). The linkage elements are arranged to form sides of one or more rhombi or parallelograms. Each linkage element is rotationally connected to another linkage elements via a revolute joint (5) at the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at the second end. The linkage elements are configured so that the axes of each joint coincide at one common remote centre of motion. The mechanism is connectable to a first external member (7) at a proximal end and is rotationally connectable to a second external member (9) at an opposite distal end to obtain three DOFs. The scissor linkage mechanism may further include a motion controlling mechanism.

IPC Classes  ?

  • B25J 18/00 - Arms
  • A61B 34/30 - Surgical robots
  • A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
  • A61H 1/02 - Stretching or bending apparatus for exercising
  • A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
  • B25J 9/00 - Programme-controlled manipulators
  • F16H 21/54 - Gearings comprising primarily only links or levers, with or without slides with movements in three dimensions for conveying or interconverting oscillating or reciprocating motions

51.

A RECONFIGURABLE COMPLIANT REVOLUTE JOINT MECHANISM WITH NONLINEAR STIFFNESS

      
Application Number DK2019050268
Publication Number 2020/052724
Status In Force
Filing Date 2019-09-11
Publication Date 2020-03-19
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Bai, Shaoping
  • Li, Zhongyi

Abstract

The invention is a new design of a compliant revolute joint mechanism, which has multiple configurations exhibiting variable stiffness performance. The joint mechanism provides compliance between its input and output shafts. Variable stiffness performance, such as soft spring, hard spring, in addition to linear spring, can be achieved by changing the mechanism configuration which is based on the wrapping pattern of elastic material, replacing the elastic material of different stiffness, or tuning their pretention force. The invention is designed with a compact structure. The new joint can be integrated into electric motors to build compliant actuators in assistive exoskeletons, rehabilitation robots and other robots where a safe human-robot interaction is concerned. The innovation can also be applied as a new coupling device, which is commonly used in motion transmissions.

IPC Classes  ?

  • B25J 9/00 - Programme-controlled manipulators
  • B25J 17/02 - Wrist joints
  • B25J 19/02 - Sensing devices
  • B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
  • B25J 19/06 - Safety devices
  • F16D 3/62 - Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members comprising pushing or pulling links attached to both parts the links or their attachments being elastic

52.

Integrated end-fire MM-wave antenna array with low frequency metal-framed antenna

      
Application Number 16557543
Grant Number 10886977
Status In Force
Filing Date 2019-08-30
First Publication Date 2020-03-05
Grant Date 2021-01-05
Owner AALBORG UNIVERSITY (Denmark)
Inventor
  • Rodriguez-Cano, Rocío
  • Zhang, Shuai
  • Pedersen, Gert Frølund

Abstract

The present subject matter relates to antenna systems, devices, and methods that are designed to avoid the degradation of the end-fire radiation pattern of the array when a piece of metal is added obstructing the direction of the main beam. A parasitic radiator is positioned in proximity to the blocking structure and configured to couple at least part of the reflected radiation pattern and radiate toward the desired end-fire direction.

IPC Classes  ?

  • H04B 7/0426 - Power distribution
  • H01Q 21/29 - Combinations of different interacting antenna units for giving a desired directional characteristic
  • H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
  • H01Q 1/24 - Supports; Mounting means by structural association with other equipment or articles with receiving set
  • H01Q 1/36 - Structural form of radiating elements, e.g. cone, spiral, umbrella
  • H01Q 5/392 - Combination of fed elements with parasitic elements the parasitic elements having dual-band or multi-band characteristics
  • H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop

53.

FLEXIBLE AND EFFICIENT SWITCHED STRING CONVERTER

      
Application Number DK2019050255
Publication Number 2020/043258
Status In Force
Filing Date 2019-08-30
Publication Date 2020-03-05
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Sera, Dezso
  • Mathe, Laszlo
  • Ricco, Mattia

Abstract

An electric converter for converting AC or DC input into an electric AC or DC output. A swap circuit with controllable electric switches serves to selectively swap connection of a plurality of DC power banks (DCBs) between an input terminal and an output terminal, thus selectively connecting the DCBs to an electric source or an electric load. The DCBs are formed as series of interconnected submodules (SMs) each having one or more electric energy storage elements (ESEs) and a switching circuit for selectively by-passing or connecting the ESEs. The ESEs can be capacitors, batteries, super capacitors, or a combination of these. By properly controlling the swap circuit and the switching of the SMs, such as by taking into account the dead-time for the electric switches involved, the converter can be used for DC-AC, DC-DC, AC-DC, or AC-AC conversion, allowing multilevel output. It can in some embodiments eliminate the need for an unfolding converter, and the converter provides a rather simple and efficient topology, suitable e.g. for connection of a DC input from a photovoltaic elements to an AC electric grid.

IPC Classes  ?

  • H02M 3/07 - Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode
  • H02M 7/483 - Converters with outputs that each can have more than two voltage levels
  • H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
  • H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers

54.

Targeting human satellite II (HSATII)

      
Application Number 16393557
Grant Number 12152241
Status In Force
Filing Date 2019-04-24
First Publication Date 2020-01-16
Grant Date 2024-11-26
Owner
  • The General Hospital Corporation (USA)
  • Aalborg University (Denmark)
Inventor
  • Ting, David T.
  • Haber, Daniel A.
  • Maheswaran, Shyamala
  • Bersani, Francesca
  • Naar, Anders M.
  • Rajurkar, Mihir Shivadatta
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

55.

Method and system for measuring the laxity of a joint of a human or an animal

      
Application Number 16476647
Grant Number 11684308
Status In Force
Filing Date 2018-01-08
First Publication Date 2020-01-02
Grant Date 2023-06-27
Owner Aalborg Universitet (Denmark)
Inventor
  • Andersen, Michael Skipper
  • Stoltze, Jonas Stensgaard
  • Pedersen, Dennis

Abstract

The invention relates to a method of determining the laxity of a joint (9, 15) of a human (5) or an animal. The method comprises providing at least one patient-specific geometrical model (1) of at least one bone and/or at least one prosthesis comprised by the joint. Known loads are applied to the joint or to a part of the body connected to the joint, and a series of actual images (16) of the joint are obtained while the loads are applied. Then the at least one patient-specific geometrical model (1) is registered onto the actual images (16). Based thereon relative displacement and/or rotation of the at least one bone and/or at least one prosthesis is calculated as a function of the applied loads, and based thereon a measure of the laxity of the joint is determined. The invention further relates to a system for performing such a method and to a computer readable medium for performing such a method.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 6/03 - Computerised tomographs
  • A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings

56.

POWER CIRCUITS FOR MODULAR MULTI-LEVEL CONVERTERS (MMC) AND MODULAR MULTI-LEVEL CONVERTERS

      
Application Number DK2019050113
Publication Number 2019/210918
Status In Force
Filing Date 2019-04-10
Publication Date 2019-11-07
Owner AALBORG UNIVERSITET (Denmark)
Inventor Munk-Nielsen, Stig

Abstract

The present invention relates to electronic power circuits and their use in power converters and in modular multi-level converters (MMCs) comprising such power converters.

IPC Classes  ?

  • H02M 7/483 - Converters with outputs that each can have more than two voltage levels
  • H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

57.

TEMPERATURE MANAGEMENT OF A SEMICONDUCTOR CHIP

      
Application Number DK2019050131
Publication Number 2019/210923
Status In Force
Filing Date 2019-04-30
Publication Date 2019-11-07
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Rezaniakolaei, Alireza
  • Rosendahl, Lasse
  • Karimirad, Meysam
  • Enkeshafi, Ali Asghar

Abstract

The invention relates to a method of controlling thermal stress of a semiconductor chip, the method comprises the steps of: establishing a modular frequency of the semiconductor chip and thereby a thermal profile of the semiconductor chip and establishing a pulsing current controlling the thermal profile of a thermoelectric cooling device thermally connected to the semiconductor chip. Wherein the pulsing current is generated in response to the modular frequency, so that a super cooling period of the thermal profile of the thermoelectric cooling device is at least partly overlapping a temperature increasing period of the thermal profile of the semiconductor chip,anda recovery period of the thermal profile of the thermoelectric cooling device is at least partly overlapping a temperature decreasing period of the thermal profile of the semiconductor chip.

IPC Classes  ?

  • H01L 23/38 - Cooling arrangements using the Peltier effect
  • H01L 35/30 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the heat-exchanging means at the junction
  • H01L 35/32 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the structure or configuration of the cell or thermocouple forming the device

58.

GENERATING SOUND ZONES USING VARIABLE SPAN FILTERS

      
Application Number DK2019050116
Publication Number 2019/197002
Status In Force
Filing Date 2019-04-12
Publication Date 2019-10-17
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Lee, Taewoong
  • Nielsen, Jesper Kjær
  • Jensen, Jesper Rindom
  • Christensen, Mads Græsbøll

Abstract

The invention provides a method for generating output filters to a plurality of loudspeakers at respective positions for playback of a plurality of different input signals in respective spatially different sound zones by means of a processor system. The method comprising computing spatio-temporal correlation matrices in response to spatial information, e.g. measured transfer functions, and in response to desired sound pressures in the plurality of sound zones. Joint eigenvalue decomposition of the spatial correlation matrices are then computed, or at least an approximation thereof, to arrive at eigenvectors accordingly. Next, variable span filters a reformed from a linear combination of the eigenvectors in response to a desired trade-off between acoustic contrast and acoustic errors in the sound zones. Finally, output filter for each of the plurality of loudspeakers,for each of the plurality of input signals, in accordance with the variable span filters.The method is applicable also for optimization in one zone, e.g. for room equalization.

IPC Classes  ?

  • H04S 7/00 - Indicating arrangements; Control arrangements, e.g. balance control

59.

INHIBITORS OF MICRO-RNA 22

      
Document Number 03093572
Status Pending
Filing Date 2019-03-14
Open to Public Date 2019-09-19
Owner
  • BETH ISRAEL DEACONESS MEDICAL CENTER (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Pandolfi, Pier Paolo
  • Panella, Riccardo
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof

60.

INHIBITORS OF MICRO-RNA 22

      
Application Number US2019022351
Publication Number 2019/178411
Status In Force
Filing Date 2019-03-14
Publication Date 2019-09-19
Owner
  • BETH ISRAEL DEACONESS MEDICAL CENTER (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Pandolfi, Pier, Paolo
  • Panella, Riccardo
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

61.

Therapeutic targeting of a microRNA to treat Duchenne muscular dystrophy

      
Application Number 16345635
Grant Number 10626395
Status In Force
Filing Date 2017-09-18
First Publication Date 2019-09-05
Grant Date 2020-04-21
Owner
  • The General Hospital Corporation (USA)
  • Aalborg University (Denmark)
Inventor
  • Naar, Anders M.
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
  • A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

62.

A TWO-TERMINAL ACTIVE INDUCTOR DEVICE

      
Application Number DK2019050064
Publication Number 2019/161867
Status In Force
Filing Date 2019-02-21
Publication Date 2019-08-29
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Huai, Wang
  • Haoran, Wang

Abstract

An active two-terminal inductor device with a controllable inducitance based on an inductance value input L_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value inductor component L1. Based on sampling of at least a voltage or a current in connection with the inductor component L1, the algorithm controls the power converter PCV to provide a resulting inductance across the external terminals A, B which serves to match the inductance value input L_I.

IPC Classes  ?

  • H02M 1/15 - Arrangements for reducing ripples from dc input or output using active elements
  • H02J 1/02 - Arrangements for reducing harmonics or ripples
  • H02J 1/14 - Balancing the load in a network
  • H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

63.

A TWO-TERMINAL ACTIVE CAPACITOR DEVICE

      
Application Number DK2019050063
Publication Number 2019/161866
Status In Force
Filing Date 2019-02-21
Publication Date 2019-08-29
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Wang, Huai
  • Wang, Haoran
  • Blaabjerg, Frede

Abstract

An active two-terminal capacitor device with a controllable capacitance based on a capacitance value input C_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value capacitor component CI. Based on sampling of at least the voltage across the capacitor component CI, the algorithm controls the power converter PCV to provide a resulting capacitance across the external terminals A, B which serves to match the capacitance value in ut C_I.

IPC Classes  ?

  • H02M 1/15 - Arrangements for reducing ripples from dc input or output using active elements
  • H02J 1/02 - Arrangements for reducing harmonics or ripples
  • H02J 1/14 - Balancing the load in a network
  • H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors

64.

Method and device for analyzing a condition of a heart

      
Application Number 16345446
Grant Number 11160487
Status In Force
Filing Date 2017-11-03
First Publication Date 2019-08-22
Grant Date 2021-11-02
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Melgaard, Jacob
  • Struijk, Johannes Jan
  • Graff, Claus

Abstract

A method for analyzing a condition of a heart, comprises receiving a plurality of electric signals, which are acquired by non-invasive measurement on the skin of a person or animal, each signal representing electrical activity in a respective region of the heart of the person or animal; calculating a derivative value of each signal at a plurality of time instances; selecting a plurality of the calculated derivative values of a first signal and determining a first point in time of a first event based on the selected derivative values; selecting a plurality of the calculated derivative values of a second signal and determining a second point in time of a second event, corresponding to the first event, based on the selected derivative values of the second signal, and calculating at least one measure based on a difference of the first point in time and the second point in time.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/366 - Detecting abnormal QRS complex, e.g. widening
  • A61N 1/37 - Monitoring; Protecting
  • A61N 1/362 - Heart stimulators
  • A61B 5/316 - Modalities, i.e. specific diagnostic methods
  • A61B 5/339 - Displays specially adapted therefor

65.

Antisense oligomers targeting HOXB-AS3 long non-coding RNA

      
Application Number 16347311
Grant Number 10787665
Status In Force
Filing Date 2017-11-03
First Publication Date 2019-08-22
Grant Date 2020-09-29
Owner
  • Ohio State Innovation Foundation (USA)
  • Aalborg University (Denmark)
Inventor
  • Garzon, Ramiro
  • Dorrance, Adrienne
  • Papaioannou, Dimitrios
  • Lee, Robert
  • Kauppinen, Sakari
  • Petri, Andreas
  • Albæk Thrue, Charlotte

Abstract

The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.

IPC Classes  ?

  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
  • A61P 35/02 - Antineoplastic agents specific for leukemia
  • A61K 9/127 - Liposomes

66.

FUEL CELL ASSEMBLY WITH A TURBULENCE INDUCING DEVICE FOR REDUCTION OF A TEMPERATURE GRADIENT

      
Application Number DK2018050368
Publication Number 2019/120415
Status In Force
Filing Date 2018-12-17
Publication Date 2019-06-27
Owner AALBORG UNIVERSITET (Denmark)
Inventor Berning, Torsten

Abstract

The present invention relates to an air-cooled fuel cell assembly (9) comprising a fuel cell (1) having a membrane electrode assembly disposed between an anode fluid flow plate and a cathode fluid flow plate, said cathode flow plate defining a flow channel for conveying oxidant to the membrane electrode assembly, said flow channel having an inlet and an outlet and said flow channel extending between two opposing perimeters (5a, 5b) of said fuel cell assembly (9), an air pump (2) arranged to generate air flow in said flow channel in a first direction (8), a turbulence inducing device (4) upstream, relative to said first direction (8), of said flow channel, said turbulence inducing device comprising a grid.

IPC Classes  ?

  • H01M 8/04089 - Arrangements for control of reactant parameters, e.g. pressure or concentration of gaseous reactants
  • H01M 8/04007 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids related to heat exchange
  • H01M 8/04014 - Heat exchange using gaseous fluids; Heat exchange by combustion of reactants
  • H01M 8/04746 - Pressure; Flow
  • H01M 8/04701 - Temperature
  • H01M 8/1018 - Polymeric electrolyte materials

67.

CARDIOVASCULAR AND CARDIORESPIRATORY FITNESS DETERMINATION

      
Application Number 16309904
Status Pending
Filing Date 2017-06-16
First Publication Date 2019-06-13
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Schmidt, Samuel Emil
  • Sorensen, Kasper
  • Sogaard, Peter
  • Struijk, Johannes Jan

Abstract

A technology for quantifying, or determining an indication of, cardiorespiratory fitness is disclosed. A signal portion is obtained from a signal recorded with an accelerometer placed on the chest of a person. The accelerometer measures accelerations and vibrations of the chest wall of the person caused by myocardial movement. A maximum value is determined in the signal portion, and output information is provided indicating cardiorespiratory fitness based on the maximum value.

IPC Classes  ?

  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

68.

COMPACT SPHERICAL 3-DOF MECHANISM CONSTRUCTED WITH SCISSOR LINKAGES

      
Application Number DK2018050262
Publication Number 2019/076417
Status In Force
Filing Date 2018-10-17
Publication Date 2019-04-25
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Castro, Miguel Nobre
  • Rasmussen, John
  • Andersen, Michael Skipper
  • Bai, Shaoping

Abstract

The invention relates to a curved scissor linkage mechanism(1)comprising at least four linkage elements(2)each having a first end (3) and a second end(4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombi or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion(RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The scissor linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end.

IPC Classes  ?

  • B25J 18/00 - Arms
  • B25J 9/00 - Programme-controlled manipulators
  • F16H 21/00 - Gearings comprising primarily only links or levers, with or without slides
  • A61B 34/30 - Surgical robots
  • E04H 15/50 - Supporting means, e.g. frames collapsible, e.g. breakdown type foldable, i.e. having pivoted or hinged means lazy-tongs type

69.

Accelerated processing for maximum distance separable codes using composite field extensions

      
Application Number 16153066
Grant Number 10819374
Status In Force
Filing Date 2018-10-05
First Publication Date 2019-04-11
Grant Date 2020-10-27
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Ruano, Diego
  • Lucani, Daniel E.
  • Geil, Olav

Abstract

Disclosed apparatus and method improve the computational efficiency of encoding and decoding data having erasures according to a maximum distance separable (MDS) code based on a Reed-Solomon code. Thus, n encoded fragments are formed by multiplying k data fragments by an n×k generator matrix for the MDS code. The code is formed by reducing, in the generator matrix to the extent possible, the size of the finite field to which entries belong—in some cases to the base field having only two elements. In this way, unlike codes known in the art, the generator matrix has more than one column whose entries each take values in the finite field having two elements. In some cases, the generator matrix has a column whose entries each take values in one or more intermediate fields between the finite field having two elements and the encoding field.

IPC Classes  ?

  • H03M 13/00 - Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
  • H03M 13/37 - Decoding methods or techniques, not specific to the particular type of coding provided for in groups
  • G06F 17/16 - Matrix or vector computation
  • G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
  • H03M 13/15 - Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
  • G06F 7/72 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations using residue arithmetic

70.

Method and apparatus to enhance routing protocols in wireless mesh networks

      
Application Number 16013373
Grant Number 11678247
Status In Force
Filing Date 2018-06-20
First Publication Date 2018-10-18
Grant Date 2023-06-13
Owner Aalborg Universitet (Denmark)
Inventor
  • Fitzek, Frank H. P.
  • Lucani, Daniel E.
  • Pahlevani, Peyman

Abstract

A protocol for use in wireless mesh networks uses helper nodes to improve data flow in the network. The protocol is compatible with traditional mesh network routing algorithms. Techniques, systems, devices, and circuits for implementing the protocol are described.

IPC Classes  ?

  • H04W 40/12 - Communication route or path selection, e.g. power-based or shortest path routing based on transmission quality or channel quality
  • H04L 12/64 - Hybrid switching systems
  • H04W 40/24 - Connectivity information management, e.g. connectivity discovery or connectivity update
  • H04W 84/18 - Self-organising networks, e.g. ad hoc networks or sensor networks

71.

METHOD FOR EXTRACTING CANNABINOIDS FROM CANNABIS PLANT MATERIAL

      
Application Number EP2018056201
Publication Number 2018/167038
Status In Force
Filing Date 2018-03-13
Publication Date 2018-09-20
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Vorobjov, Filip
  • Søgaard, Erik, Gydesen

Abstract

The present invention relates to a method for extracting cannabinoids from cannabis plant material using an extractor with super critical carbon dioxide. The process comprises the steps of: a) providing a cannabis plant material with a water content of at most 60% w/w, preferably at most 10% w/w; b1) in a pressure tank, subjecting the cannabis plant material to a first extraction step with a one-phase solvent system comprising supercritical carbon dioxide and optionally a non-polar co-solvent, and performed at a temperature of about 30-60 degrees Celsius; c1) collecting a first liquid extract from the pressure tank; d) collecting/removing a solid product from the pressure tank comprising a cannabis plant fiber material with a reduced content of cannabinoids; e) dissolving the first liquid extract from the pressure tank in ethanol, subjecting the solution to one or more winterization steps, filtrating the solution to remove precipitated matter, and removing the ethanol to collect a second liquid extract; f) optionally, heat treating the second liquid extract at 100-150 degrees Celsius to decarboxylate any acid form of the cannabinoids to the neutral form of the cannabinoids; g) dissolving the second liquid extract, optionally heat treated, in a non-polar solvent; h) extracting the solubilized second liquid extract with an aqueous basic solution; and collecting the non-polar solvent phase as a third liquid extract; and i) optionally, removing the non-polar solvent to collect the neutral form of the cannabinoids.

IPC Classes  ?

  • B01D 11/02 - Solvent extraction of solids
  • A61K 31/00 - Medicinal preparations containing organic active ingredients

72.

A METHOD FOR DIAGNOSING A MIGRAINE

      
Application Number EP2018054671
Publication Number 2018/154111
Status In Force
Filing Date 2018-02-26
Publication Date 2018-08-30
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Gazerani, Parisa
  • Duroux, Meg

Abstract

The invention relates to a method of diagnosing a migraine and/or migraine attack, the method in a subject comprising determining a change in the expression level of a biological marker in the biological sample. Preferably, the method is the in vitro method.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

73.

METHOD AND SYSTEM FOR MEASURING THE LAXITY OF A JOINT OF A HUMAN OR AN ANIMAL

      
Application Number DK2018050003
Publication Number 2018/130256
Status In Force
Filing Date 2018-01-08
Publication Date 2018-07-19
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Andersen, Michael Skipper
  • Stoltze, Jonas Stensgaard
  • Pedersen, Dennis

Abstract

The invention relates to a method of determining the laxity of a joint (9, 15) of a human (5) or an animal. The method comprises providing at least one patient-specific geometrical model (1) of at least one bone and/or at least one prosthesis comprised by the joint. Known loads are applied to the joint or to a part of the body connected to the joint, and a series of actual images (16) of the joint are obtained while the loads are applied. Then the at least one patient-specific geometrical model (1) is registered onto the actual images (16). Based thereon relative displacement and/or rotation of the at least one bone and/or at least one prosthesis is calculated as a function of the applied loads, and based thereon a measure of the laxity of the joint is determined. The invention further relates to a system for performing such a method and to a computer readable medium for performing such a method.

IPC Classes  ?

  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
  • A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations

74.

JUNCTION TEMPERATURE MEASUREMENT IN A POWER SEMICONDUCTOR MODULE

      
Application Number DK2017050366
Publication Number 2018/086666
Status In Force
Filing Date 2017-11-08
Publication Date 2018-05-17
Owner AALBORG UNIVERSITET (Denmark)
Inventor Baker, Nick

Abstract

A method for determining the temperature of a power semiconductor, where the power semiconductor includes an auxiliary emitter terminal and an emitter terminal, and a resistance component arranged between. The resistance component is thermally coupled and/or integrated into the semiconductor die. The resistance component is arranged between the auxiliary emitter terminal and the emitter terminal, and lies in the path of the control current. The resistance component has a temperature dependent resistance characteristic. A measurement circuit is used to inject a sufficient sensing current, or apply a suitable voltage, to the resistance component between the auxiliary emitter and emitter terminals, in order to generate an output signal that is dependent on the temperature dependent resistance of the resistance component. The output signal can be assessed with respect to a predefined temperature characteristic curve, obtained through a calibration procedure. Thus, the temperature of the semiconductor is measured.

IPC Classes  ?

  • G01K 7/16 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements

75.

COLORECTAL CANCER METHYLATION MARKERS

      
Application Number EP2017078573
Publication Number 2018/087129
Status In Force
Filing Date 2017-11-08
Publication Date 2018-05-17
Owner
  • REGION NORDJYLLAND, AALBORG UNIVERSITY HOSPITAL (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Thorlacius-Ussing, Ole
  • Ladefoged Rasmussen, Simon
  • Bygum Krarup, Henrik
  • Madsen, Poul Henning

Abstract

A method is provided for determining colorectal cancer, or the prognosis of a colorectal cancer in a subject, said method comprising in a sample from said subject determining the methylation status of a specific gene marker panel.

IPC Classes  ?

  • C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

76.

METHOD AND DEVICE FOR ANALYZING A CONDITION OF A HEART

      
Application Number EP2017078129
Publication Number 2018/083210
Status In Force
Filing Date 2017-11-03
Publication Date 2018-05-11
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Melgaard, Jacob
  • Struijk, Johannes, Jan
  • Graff, Claus

Abstract

A method for analyzing a condition of a heart, comprises receiving a plurality of electrical signals, which are acquired by non-invasive measurement on the skin of a person or animal, each signal representing electrical activity in a respective region of the heart of the person or animal; calculating a derivative value of each signal at a plurality of time instances; selecting a plurality of the calculated derivative values of a first signal and determining a first point in time of a first event based on the selected derivative values; selecting a plurality of the calculated derivative values of a second signal and determining a second point in time of a second event, corresponding to the first event, based on the selected derivative values of the second signal, and calculating at least one measure based on a difference of the first point in time and the second point in time.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61N 1/362 - Heart stimulators

77.

ANTISENSE OLIGOMERS TARGETING HOXB-AS3 LONG NON-CODING RNA

      
Application Number US2017059932
Publication Number 2018/085656
Status In Force
Filing Date 2017-11-03
Publication Date 2018-05-11
Owner
  • OHIO STATE INNOVATION FOUNDATION (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Garzon, Ramiro
  • Dorrance, Adrienne
  • Papaioannou, Dimitrios
  • Lee, Robert
  • Kauppinen, Sakari
  • Petri, Andreas
  • Albæk Thrue, Charlotte

Abstract

The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.

IPC Classes  ?

  • A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • A61P 35/02 - Antineoplastic agents specific for leukemia

78.

THERAPEUTIC TARGETING OF A MICRORNA TO TREAT DUCHENNE MUSCULAR DYSTROPHY

      
Application Number US2017052047
Publication Number 2018/080658
Status In Force
Filing Date 2017-09-18
Publication Date 2018-05-03
Owner AALBORG UNIVERSITY (Denmark)
Inventor
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

IPC Classes  ?

  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
  • A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
  • A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

79.

BIOFEEDBACK FOR REDUCING MUSCULOSKELETAL PAIN

      
Application Number DK2017050320
Publication Number 2018/059645
Status In Force
Filing Date 2017-09-29
Publication Date 2018-04-05
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Mrachacz-Kersting, Natalie
  • Frahm, Sabata Gervasio

Abstract

A neurofeedback system can be used by a person for training, so as to reduce musculoskeletal pain. The system comprises a non-invasive EEG sensor to sense EEG signal from the person. A processor system, e.g. a tablet or the like, receives data values from the EEG sensor and calculates a EEG power magnitude within the EEG alpha band accordingly. The processor system is programmed to determine a baseline value indicative of EEG alpha band power, and determine, in real-time, EEG alpha band power in response to data from the EEG sensor. On a display, the processor system displays a real-time visual indication of the EEG alpha band power values compared to said baseline value. At least one attribute, e.g. color, of the visual indication is determined in response to the real-time values being above or below a threshold which is determined in response to said baseline value. In preferred embodiments, a feedback device with a sensor for sensing a start of body movement of the person provides timing feedback to the processor system to allow calculation of EEG alpha power in the preparation phase before start of the movement, and to use this as the visual EEG feedback. Specific frequency-time signatures for a specific type of pain may be used for the baseline value used in the feedback to the person during training.

IPC Classes  ?

  • A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
  • A61B 5/048 - Detecting the frequency distribution of signals
  • A61B 5/0482 - Electroencephalography using biofeedback
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

80.

A HUMAN INTENTION DETECTION SYSTEM FOR MOTION ASSISTANCE

      
Application Number DK2017050290
Publication Number 2018/050191
Status In Force
Filing Date 2017-09-14
Publication Date 2018-03-22
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Bai, Shaoping
  • Islam, Muhammad Raza Ul

Abstract

Adevice and method for human intention detection (HID). In preferred embodiments, it makes use of an array of force sensing resistors (FSRs) which are embedded inside a flexible band, which is capable of reading the muscle activity for different motion type and muscle forcein a human user. In one implementation of the invention two of such bands are attached to the forearm and the upper arm. From the readings of the sensors, the patterns for motion type and muscle forceare then distinguished autonomously by machine learning, a Support Vector Machine (SVM)algorithm, or a neural network. The method is advantageous e.g. the detection of dexterous motion of the arms, upon which assistive exoskeleton can be controlled for motion assistance. The invention can also be applicable to hand gestures recognition and bilateral rehabilitation, besides this the invention can be used to control lower body exoskeleton as well.

IPC Classes  ?

81.

Assessment of nerve fiber excitability

      
Application Number 15558759
Grant Number 10791955
Status In Force
Filing Date 2016-03-17
First Publication Date 2018-03-08
Grant Date 2020-10-06
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Hennings, Kristian
  • Dahl Mørch, Carsten
  • Kæseler Andersen, Ole
  • Arendt-Nielsen, Lars

Abstract

A method for assessing nerve fiber excitability is disclosed. The method comprises: arranging an electrode in contact with skin of a person; determining a first and a second threshold value based on a stimulation current pulse of a first and a second waveform, respectively; wherein said determining of the first threshold value and said determining of the second threshold value each comprises: repeatedly providing a stimulation current pulse of the first or second waveform, respectively, through the electrode, wherein a stimulation current strength is altered between repetitions; and receiving signals from an interaction element with which the person interacts, said signals from the interaction element providing an indication of the first threshold value or the second threshold value, respectively, corresponding to a stimulation current strength necessary to be perceived by the person; and determining at least one measure of psychophysical perception based on the determined first and second threshold values.

IPC Classes  ?

  • A61B 5/0488 - Electromyography
  • A61B 5/0484 - Electroencephalography using evoked response
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61N 1/04 - Electrodes
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

82.

ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS

      
Application Number EP2017069725
Publication Number 2018/024849
Status In Force
Filing Date 2017-08-03
Publication Date 2018-02-08
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kauppinen, Sakari
  • Petri, Andreas
  • Albæk Thrue, Charlotte

Abstract

The present invention provides antisense oligonucleotides directed against immune checkpoints and methods and compositions of using such antisense oligonucleotides for the treatment of cancer.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

83.

SYSTEMS AND METHODS FOR ESTIMATING CARDIAC STRAIN AND DISPLACEMENT USING ULTRASOUND

      
Application Number US2017039290
Publication Number 2017/223563
Status In Force
Filing Date 2017-06-26
Publication Date 2017-12-28
Owner
  • DUKE UNIVERSITY (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Ramm, Olaf Von
  • Kisslo, Joseph
  • Moore, Cooper
  • Vandborg Andersen, Martin
  • Schmidt, Samuel Emil
  • Sogaard, Peter
  • Ostergaard, Lasse Riis

Abstract

Systems and methods for estimating cardiac strain and displacement using ultrasound are disclosed. According to an aspect, a method includes receiving frames of images acquired from a subject over a period of time. The method also includes determining, in the frames of images, speckles of features of the subject. Further, the method includes tracking bulk movement of the speckles in the frame of images. The method also includes determining displacement of at least a portion of the subject based on the tracked bulk movement.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/026 - Measuring blood flow
  • A61B 5/0402 - Electrocardiography, i.e. ECG
  • A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings

84.

CARDIOVASCULAR AND CARDIORESPIRATORY FITNESS DETERMINATION

      
Application Number EP2017064835
Publication Number 2017/216375
Status In Force
Filing Date 2017-06-16
Publication Date 2017-12-21
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Schmidt, Samuel Emil
  • Sørensen, Kasper
  • Søgaard, Peter
  • Struijk, Johannes Jan

Abstract

A technology for quantifying, or determining an indication of, cardiorespiratory fitness is disclosed. A signal portion is obtained from a signal recorded with an accelerometer placed on the chest of a person. The accelerometer measures accelerations and vibrations of the chest wall of the person caused by myocardial movement. A maximum value is determined in the signal portion, and output information is provided indicating cardiorespiratory fitness based on the maximum value.

IPC Classes  ?

  • A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

85.

METHOD AND SYSTEM FOR MEASURING AORTIC PULSE WAVE VELOCITY

      
Application Number EP2017063780
Publication Number 2017/211866
Status In Force
Filing Date 2017-06-07
Publication Date 2017-12-14
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kjær Thing Riknagel, Diana
  • Struijk, Johannes Jan

Abstract

The present invention relates to a method and system for determining the aortic pulse wave velocity. The method comprises receiving an indication of a measurement of a length of a human aorta to provide an aortic length, arranging a first and second sound transducer outside the body of the patient, and identifying the opening of the aortic valve with measurement from the first sound transducer as a first time, and the pulse wave arrival time at the aortic bifurcation with measurements from the second sound transducer as a second time. The aortic transit time is determined based on the difference between the second time and the first time, and the aortic pulse wave velocity is calculated based on the aortic length and the aortic transit time.

IPC Classes  ?

  • A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
  • A61B 7/04 - Electric stethoscopes
  • A61B 5/0285 - Measuring phase velocity of blood waves

86.

ANTISENSE OLIGONUCLEOTIDES FOR MODULATION OF LONG NONCODING RNAS

      
Application Number EP2017064047
Publication Number 2017/211999
Status In Force
Filing Date 2017-06-08
Publication Date 2017-12-14
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Kauppinen, Sakari
  • Petri, Andreas
  • Albæk Thrue, Charlotte

Abstract

The present invention relates to noncoding RNAs as novel disease targets, and methods of modulating the activity of such ncRNA targets in patients. In particular, the invention relates to modulation of long non-coding RNAs, such as circular RNAs (circRNAs) or large intergenic noncoding RNAs (lincRNAs) in cancer using antisense oligonucleotides.

IPC Classes  ?

  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

87.

SPHERICAL JOINT MECHANISM WITH A DOUBLE PARALLELOGRAM MECHANISM

      
Application Number DK2017050100
Publication Number 2017/167349
Status In Force
Filing Date 2017-03-31
Publication Date 2017-10-05
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Christensen, Simon
  • Bai, Shaoping

Abstract

The invention relates to a spherical joint mechanism comprising two revolute joints joined by a double parallelogram linkage. The double parallelogram linkage comprises a first linkage part hingedly connected to a first revolute joint at a distal end and a second linkage part hingedly connected to a second revolute joint at a distal end. The first linkage part comprises a first link arm and a second link arm, which first and second link arms are arranged to move parallel to each other. The second linkage part comprises a third link arm and a fourth link arm, which third and fourth link arms are arranged to move parallel to each other. A proximate end of the first linkage part and a proximate end of the second linkage part are mutually hingedly connected. The invention also relates to an exoskeleton with a shoulder joint or a hip joint comprising such a spherical joint mechanism.

IPC Classes  ?

  • A61H 1/02 - Stretching or bending apparatus for exercising
  • A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
  • B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

88.

Targeting human satellite II (HSATII)

      
Application Number 15321391
Grant Number 10301624
Status In Force
Filing Date 2015-06-25
First Publication Date 2017-07-13
Grant Date 2019-05-28
Owner
  • The General Hospital Corporation (USA)
  • Aalborg University (Denmark)
Inventor
  • Ting, David T.
  • Haber, Daniel A.
  • Maheswaran, Shyamala
  • Bersani, Francesca
  • Naar, Anders M.
  • Rajurkar, Mihir Shivadatta
  • Kauppinen, Sakari
  • Petri, Andreas

Abstract

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.

IPC Classes  ?

  • C12N 15/11 - DNA or RNA fragments; Modified forms thereof
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
  • C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
  • C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

89.

A CPN-BASED TOOL FOR THE STRATIFICATION OF ILLNESS SEVERITY IN PATIENTS SUSPECTED OF SEPSIS

      
Application Number DK2016050288
Publication Number 2017/036482
Status In Force
Filing Date 2016-08-26
Publication Date 2017-03-09
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Ward, Logan
  • Andreassen, Steen

Abstract

There is presented a computer implemented method for calculating a probability of a clinical outcome for a patient, wherein the method comprises providing a maximum of 150 input parameters, such as a maximum of 20 input parameters, as input to a statistical model, and calculating the probability with the statistical model. The method in an embodiment further comprises performing with the statistical model an assessment of a severity of an illness of the patient, where said assessment is based partially or fully on the input parameters, and where said probability is based partially or fully on the severity of the patient's illness.

IPC Classes  ?

  • G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
  • G06N 7/00 - Computing arrangements based on specific mathematical models

90.

A TRIPLE CO-CULTURE MODEL OF THE BLOOD-BRAIN BARRIER USING PRIMARY PORCINE BRAIN ENDOTHELIAL CELLS, PORCINE PERICYTES AND PORCINE ASTROCYTES

      
Application Number DK2016050190
Publication Number 2016/202343
Status In Force
Filing Date 2016-06-16
Publication Date 2016-12-22
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Thomsen, Louiza Bohn
  • Larsen, Annette Burkhart
  • Moos, Torben

Abstract

The present invention relates to an in vitro blood-brain-barrier (BBB) model comprising a porcine triple co-culture comprising porcine astrocytes, porcine primary brain endothelial cells (BEC's) and porcine pericytes. The invention also relates methods of producing such porcine triple co-cultures and uses thereof.

IPC Classes  ?

  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
  • C12N 5/079 - Neural cells
  • G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

91.

DOUBLE U-CORE SWITCHED RELUCTANCE MACHINE

      
Application Number DK2016050178
Publication Number 2016/198079
Status In Force
Filing Date 2016-06-10
Publication Date 2016-12-15
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Rasmussen, Peter Omand
  • Kongerslev, Kristian
  • Jæger, Rasmus
  • Nielsen, Simon Staal

Abstract

The present invention relates to an electrical machine stator comprising a plurality of stator segments (131,132,133), each segment comprises a first U-core and a second U-core wound with a winding, where the winding being arranged with at least one coil turn, each coil turn comprises a first axial coil segment and a second axial coil segment and one or more end segments, wherein the first and second axial coil segments are arranged in opposite directions to each other, and where the first U-core receives the first axial coil segment(s) and the second U-core receives the second axial coil segment(s), wherein the first U-core and the second U-core are located adjacent to each other, whereby the winding spans the first and second U-cores. The invention also relates to a SRM machine with a stator mentioned above and a rotor.

IPC Classes  ?

  • H02K 1/14 - Stator cores with salient poles
  • H02K 1/18 - Means for mounting or fastening magnetic stationary parts on to, or to, the stator structures
  • H02K 1/20 - Stationary parts of the magnetic circuit with channels or ducts for flow of cooling medium
  • H02K 1/24 - Rotor cores with salient poles
  • H02K 5/173 - Means for supporting bearings, e.g. insulating supports or means for fitting bearings in the bearing-shields using bearings with rolling contact, e.g. ball bearings
  • H02K 7/08 - Structural association with bearings
  • H02K 7/116 - Structural association with clutches, brakes, gears, pulleys or mechanical starters with gears
  • H02K 19/10 - Synchronous motors for multi-phase current

92.

Composite extension finite fields for low overhead network coding

      
Application Number 14948414
Grant Number 09787614
Status In Force
Filing Date 2015-11-23
First Publication Date 2016-12-08
Grant Date 2017-10-10
Owner
  • Aalborg Universitet (Denmark)
  • Steinwurf ApS (Denmark)
Inventor
  • Heide, Janus
  • Lucani, Daniel E.

Abstract

Described are network coding (NC) systems and techniques which utilize multiple composite extension finite fields to reduce complexity at various nodes in a network and also reduce overhead due to signal coding coefficients. A coding design uses a series of finite fields where increasingly larger fields are based on a previous smaller field. Techniques disclosed herein can be applied to existing systems using Random Linear Network Coding (RLNC) or Fulcrum codes.

IPC Classes  ?

  • H04L 12/861 - Packet buffering or queuing arrangements; Queue scheduling
  • H04L 1/00 - Arrangements for detecting or preventing errors in the information received

93.

INFLATABLE CUFF FOR PAIN MODULATION OR PAIN ASSESSMENT

      
Application Number EP2016061924
Publication Number 2016/189093
Status In Force
Filing Date 2016-05-26
Publication Date 2016-12-01
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Graven-Nielsen, Thomas
  • Arendt-Nielsen, Lars
  • Kjær Petersen, Kristian

Abstract

The present invention describes an inflatable cuff 1 for inducing at least compressional or shear force on a subject and evaluating pain thresholds and/or sensitivity, pain modulation, spatial and/or temporal summation of pain, or descending inhibition of pain in the subject, said cuff comprising at least two separate chambers 2, 3 of which at least one is an inflation chamber 3 and at least one is a non-inflation chamber 2, wherein the inflation chamber 3 has a coupling 4for connection to a compressor or other activator device.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

94.

BIOMARKERS FOR PREDICTION OF DEVELOPMENT OF HYPOXEMIA DUE TO ACUTE LUNG INJURY

      
Application Number DK2016050138
Publication Number 2016/188530
Status In Force
Filing Date 2016-05-20
Publication Date 2016-12-01
Owner
  • REGION NORDJYLLAND, AALBORG SYGEHUS (Denmark)
  • AALBORG UNIVERSITET (Denmark)
Inventor
  • Maltesen, Raluca Georgiana
  • Rasmussen, Bodil Steen
  • Wimmer, Reinhard
  • Pedersen, Shona
  • Kristensen, Søren Risom
  • Hanifa, Munsoor Ali

Abstract

The present invention relates to a set of biomarkers, which can be used to determinethe risk of developing hypoxemia for subjects undergoingopen heart surgery with the use of cardiopulmonary bypass (CPB).

IPC Classes  ?

  • G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

95.

Method and apparatus for measurement and control of linear actuator

      
Application Number 14715924
Grant Number 09628001
Status In Force
Filing Date 2015-05-19
First Publication Date 2016-11-24
Grant Date 2017-04-18
Owner
  • GM GLOBAL TECHNOLOGY OPERATIONS LLC (USA)
  • AALBORG UNIVERSITY (Denmark)
Inventor
  • Trangbaek, Klaus
  • Suplin, Vladimir
  • Holm, Rasmus Koldborg
  • Berg, Nick Ilso
  • Rasmussen, Peter Omand

Abstract

An apparatus for controlling force of a magnetic lead screw actuator includes a magnetic lead screw actuator, an external control module and at least one sensor device integrated within the magnetic lead screw actuator. The magnetic lead screw actuator includes an electric machine, a rotor, and a translator. The rotor includes a rotor magnet assembly forming first helical magnetic threads along the rotor and the translator includes a translator magnet assembly forming second helical magnetic threads along the translator. Rotation of the rotor by the electric machine effects linear translation of the translator by interaction of the first and second helical magnetic threads. The external control module is electrically operatively coupled to an electric machine controller of the magnetic lead screw actuator. The at least one sensor device integrated within the magnetic lead screw actuator is configured to measure a parameter indicative of a relative displacement between the rotor and the translator and this parameter is provided as feedback to the electric machine controller.

IPC Classes  ?

  • H02K 41/00 - Propulsion systems in which a rigid body is moved along a path due to dynamo-electric interaction between the body and a magnetic field travelling along the path
  • H02P 1/00 - Arrangements for starting electric motors or dynamo-electric converters
  • H02P 3/00 - Arrangements for stopping or slowing electric motors, generators, or dynamo-electric converters
  • H02P 5/00 - Arrangements specially adapted for regulating or controlling the speed or torque of two or more electric motors
  • H02P 6/00 - Arrangements for controlling synchronous motors or other dynamo-electric motors using electronic commutation dependent on the rotor position; Electronic commutators therefor
  • H02K 1/27 - Rotor cores with permanent magnets
  • H02K 7/06 - Means for converting reciprocating motion into rotary motion or vice versa
  • H02K 7/116 - Structural association with clutches, brakes, gears, pulleys or mechanical starters with gears
  • H02K 11/215 - Magnetic effect devices, e.g. Hall-effect or magneto-resistive elements

96.

ASSESSMENT OF NERVE FIBER EXCITABILITY

      
Application Number EP2016055826
Publication Number 2016/146758
Status In Force
Filing Date 2016-03-17
Publication Date 2016-09-22
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Hennings, Kristian
  • Dahl Mørch, Carsten
  • Kæseler Andersen, Ole
  • Arendt-Nielsen, Lars

Abstract

A method for assessing nerve fiber excitability is disclosed. The method comprises: arranging an electrode in contact with skin of a person; determining a first and a second threshold value based on a stimulation current pulse of a first and a second waveform, respectively; wherein said determining of the first threshold value and said determining of the second threshold value each comprises: repeatedly providing a stimulation current pulse of the first or second waveform, respectively, through the electrode, wherein a stimulation current strength is altered between repetitions; and receiving signals from an interaction element with which the person interacts, said signals from the interaction element providing an indication of the first threshold value or the second threshold value, respectively, corresponding to a stimulation current strength necessary to be perceived by the person; and determining at least one measure of psychophysical perception based on the determined first and second threshold values.

IPC Classes  ?

  • A61B 5/0488 - Electromyography
  • A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

97.

Actuator system with dual chambers

      
Application Number 15034042
Grant Number 09835222
Status In Force
Filing Date 2014-11-10
First Publication Date 2016-09-15
Grant Date 2017-12-05
Owner Aalborg Universitet (Denmark)
Inventor
  • Berg, Nick Ilso
  • Holm, Rasmus Koldborg
  • Rasmussen, Peter Omand

Abstract

The present invention relates to an actuator system with a magnetic lead screw, comprises a magnetic rotor and a translator cylinder, the translator cylinder comprises a magnetic stator, the translator cylinder has a closed first end and a second end confined by a lid, the lid having a shaft opening for a shaft coupled to the magnetic rotor, wherein the magnetic rotor, when inserted in the translator cylinder, is arranged to translate a linear movement of the translator cylinder into a rotational movement of the magnetic rotor by using magnetic flux interacting between the magnetic stator and the magnetic rotor, said rotational movements is being transferred through a shaft, the lid with a shaft opening arranged for receiving the shaft, wherein the shaft is arranged to make both the linear and the rotational movement in the shaft opening, the lid being arranged for confining the second end of the translator cylinder, the translator cylinder confined by the lid forms, when divided by the magnetic rotor, a first chamber with a first volume and a second chamber with a second volume, wherein the first volume and the second volume changes as a function of the linear movement. The invention also relates to a method of operating an actuator system with a magnetic lead screw.

IPC Classes  ?

  • F16F 13/00 - Units comprising springs of the non-fluid type as well as vibration-dampers, shock-absorbers, or fluid springs
  • F04B 17/04 - Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors using solenoids
  • F04B 19/02 - Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups having movable cylinders
  • H02K 49/10 - Dynamo-electric clutches; Dynamo-electric brakes of the permanent-magnet type
  • B60G 15/04 - Resilient suspensions characterised by arrangement, location, or type of combined spring and vibration- damper, e.g. telescopic type having mechanical spring and mechanical damper
  • B60G 17/015 - Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or s the regulating means comprising electric or electronic elements
  • F16H 25/24 - Elements essential to such mechanisms, e.g. screws, nuts

98.

A METHOD OF DIRECTLY DETERMINING THE WATER BALANCE IN FUEL CELLS

      
Application Number DK2016050037
Publication Number 2016/128000
Status In Force
Filing Date 2016-02-12
Publication Date 2016-08-18
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Berning, Torsten
  • Al Shakhshir, Saher

Abstract

The present invention relates to a method of determining the water balance of a proton exchange membrane fuel cell, characterized by the net water drag coefficient (rd),by employing constant temperature anemometry (CTA). rd can be directly determined by collecting and processing a working voltage signal across a heated wire of a constant temperature anemometer located at the outlet of the anode of a fuel cell.

IPC Classes  ?

  • H01M 8/04492 - Humidity; Ambient humidity; Water content
  • H01M 8/04537 - Electric variables
  • H01M 8/1018 - Polymeric electrolyte materials
  • H01M 8/04119 - Arrangements for control of reactant parameters, e.g. pressure or concentration of gaseous reactants with simultaneous supply or evacuation of electrolyte; Humidifying or dehumidifying

99.

Method for functionalizing a solid material surface with self assembling or self aggregating cyclodextrins and products thereof

      
Application Number 14992932
Grant Number 09970152
Status In Force
Filing Date 2016-01-11
First Publication Date 2016-07-07
Grant Date 2018-05-15
Owner Aalborg Universitet (Denmark)
Inventor
  • Larsen, Kim Lambertsen
  • Nielsen, Ronnie
  • Styrbæk, Karen Østergaard

Abstract

The present invention relates to a method for functionalizing a solid material surface with self assembling or self aggregating cyclodextrins, said method comprising the steps of: providing an adsorption solution comprising at least one modified cyclodextrin and at least one solvent; and contacting a solid material surface with the adsorption solution.

IPC Classes  ?

  • C09D 105/16 - Cyclodextrin; Derivatives thereof
  • D06M 15/03 - Polysaccharides or derivatives thereof
  • C08B 37/00 - Preparation of polysaccharides not provided for in groups ; Derivatives thereof
  • C08B 37/16 - Cyclodextrin; Derivatives thereof
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators

100.

Method for file updating and version control for linear erasure coded and network coded storage

      
Application Number 14973850
Grant Number 10270468
Status In Force
Filing Date 2015-12-18
First Publication Date 2016-06-23
Grant Date 2019-04-23
Owner AALBORG UNIVERSITET (Denmark)
Inventor
  • Sipos, Márton A.
  • Lucani, Daniel E.
  • Heide, Janus
  • Pedersen, Morten V.
  • Fitzek, Frank H. P.

Abstract

A method for use in a distributed storage system having a plurality of nodes, the method including receiving, at a source node, original data, encoding the original data into plurality of coded fragments using a linear code, transmitting at least a first one of the coded fragments from the source node to a first sink node. The method further includes receiving, at the source node, modified data, calculating, at the source node, a coded difference between the original data and the modified data, transmitting the coded difference from the source node to the first sink node; and recovering, at the first sink node, at least a first portion of the modified data using the coded difference and the at least a first one of the coded fragments.

IPC Classes  ?

  • H03M 13/00 - Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
  • H03M 13/15 - Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
  • G06F 3/06 - Digital input from, or digital output to, record carriers
  • G06F 11/10 - Adding special bits or symbols to the coded information, e.g. parity check, casting out nines or elevens
  • H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
  • G06F 11/14 - Error detection or correction of the data by redundancy in operation, e.g. by using different operation sequences leading to the same result
  • G06F 8/658 - Incremental updates; Differential updates
  • H03M 13/13 - Linear codes
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