Abrégé

The invention relates to a method of manufacturing a vessel (21) suitable for storage of pressurized fluid. The method comprises providing a body (22) forming an inner vessel cavity, the body having an inlet (25) providing an opening into the inner vessel cavity, providing at least one reinforcing element (1) and arranging it aligned with the inlet, winding continuous fibre reinforcement (24) around the body to form the vessel, and solidifying the matrix material impregnating the fibres. The at least one reinforcing element comprises a circumferential member (2) with a through-going hole (9), and a plurality of element fibres (3) extending away from the circumferential member while being in engagement with the circumferential member. During the winding, it is ensured that the element fibres are arranged in an overlapping and/or sandwiching engagement with the continuous fibre reinforcement over a region around the inlet.

Classes IPC  ?

• F17C 1/06 - Enveloppes protectrices constituées par un enroulement de bandes ou de matériaux filiformes p. ex. fils métalliques
• F17C 13/04 - Disposition ou montage des soupapes

Abrégé

The present invention relates to a cyclodextrin derivative of formula (I), wherein the cyclodextrin derivative has an average percentage of primary substitution (Rp) to total substitution with the substituted alkyl in the range of 15-99 %. The invention also relates to a composition comprising said cyclodextrin derivatives, a drug-cyclodextrin complex, use of a cyclodextrin derivative and a manufacturing method thereof.

Classes IPC  ?

• C08B 37/16 - CyclodextrineSes dérivés

Abrégé

The present invention concerns a planar winding assembly for power applications, said assembly comprising a frame accommodating a stack of a plurality of printed circuit board (PCB) modules, each comprising a plurality of conductive windings on the PCB module, wherein the stack comprises an uppermost first PCB module comprising an electrically insulating layer having a first surface and a second surface, where the second surface is provided with at least two conductive winding sections having a first winding pattern and where said second surface is facing downwards; at least one second PCB module comprising an electrically insulating layer having a top surface and a bottom surface, where both surfaces are provided with a second winding pattern corresponding to the first winding pattern; a lowermost first PCB module, which is positioned with said first winding pattern on the second surface facing upwards; means for holding the plurality of PCB modules tightly against each other in the stacked configuration, said holding means comprising a frame encompasses the stack of PCB modules.

Classes IPC  ?

• H01F 5/00 - Bobines d'induction
• H01F 5/04 - Dispositions des connexions électriques aux bobines, p. ex. fils de connexion
• H01F 27/28 - BobinesEnroulementsConnexions conductrices
• H01F 27/30 - Fixation ou serrage de bobines, d'enroulements ou de parties de ceux-ci entre euxFixation ou montage des bobines ou enroulements sur le noyau, dans l'enveloppe ou sur un autre support
• H05K 1/14 - Association structurale de plusieurs circuits imprimés

Abrégé

The present invention relates to a device (1) and a method for sensing vibrations in a human's skin (2) emanating from blood flowing in a natural or artificial blood vessel or an arteriovenous fistula (AVF) (3) located below the skin. The device comprises a sensor (4), a controller (5), a transmitter (6), and an electrical power source (7). In particular, the invention relates to such a device that is configured to be fastened to the human and carried around by the human during use of the device. The measured signals are analysed, and if the blood flow is below a pre-selected blood flow threshold, an alarm signal is issued to warn e.g. a responsible medical doctor that there is a need for further assessment.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/0295 - Mesure du débit sanguin utilisant la pléthysmographie, c.-à-d. par mesure des variations du volume d'une partie du corps induites par la circulation du sang qui traverse cette partie, p. ex. pléthysmographie par impédance

Abrégé

An air flow measurement system for determining an air flow value indicative of air flow in an associated air duct system with an air duct and a controllable damper to control air flow in the air duct by means of a damper blade which has a controllable position, such as around an axis of rotation. An air flow sensor, preferably an EFV based sensor, is arranged for being positioned inside the associated air duct at or near a wall of the air duct and downstream of the controllable damper in proximity to the controllable damper. The air flow sensor is connected to a flow measurement system, and a processor processes an output from the flow measurement circuit to determine a measured air speed accordingly. The processor can then calculate the air flow value based on the measured air speed, preferably further based on a damper blade position, and a correction value. The measurement system can measure very low air speeds e.g. in a ventilation duct with high accuracy, such as down to 0.2 m/s. To protect the air flow sensor from dirt particles, an obstacle element can be placed upstream of the sensor, i.e. in the form of a pin or rod.

Classes IPC  ?

• G01F 1/20 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques par détection des effets dynamiques de l’écoulement
• G01F 1/26 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques par détection des effets dynamiques de l’écoulement par débitmètres à section variable du type à clapet
• G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
• G01F 1/36 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression la pression ou la différence de pression étant produite par une contraction de la veine fluide
• F24F 110/30 - Vitesse

Abrégé

The present invention relates to multi-step or cascade extraction process for extracting bio-active compounds from non-food fractions of saline, fresh green or lignified biomasses such as halophytes and seaweed. The extraction processes can also be used for treating circular feedstocks, such as polyphenolic rich circular feedstocks.

Classes IPC  ?

• A61K 36/21 - Amaranthaceae (famille de l'amaranthe), p. ex. amaranthe réfléchie ou amarantine globuleuse
• A61K 36/02 - Algues
• A61K 36/23 - Apiaceae ou Umbelliferae (famille de la carotte), p. ex. aneth, cerfeuil, coriandre ou cumin
• A61K 36/28 - Asteraceae ou Compositae (famille de l'aster ou du tournesol), p. ex. camomille, chrysanthème matricaire, achillée ou echinacée
• A61P 31/04 - Agents antibactériens
• B01D 11/02 - Extraction par solvants de solides
• A01N 65/08 - Magnoliopsida [dicotylédones]

Abrégé

The present invention relates to methods of producing halophyte extract. In particular the present invention relates to the use of halophyte extract for reducing MIC-bacteria, especially sulphate-reducing bacteria and/or biofilm.

Classes IPC  ?

• A01N 65/08 - Magnoliopsida [dicotylédones]
• A01N 65/12 - Asteraceae ou Compositae [famille de l'aster ou du tournesol], p. ex. marguerite, pyrèthre, artichaut, laitue, tournesol, armoise ou estragon
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges

Abrégé

A method for producing plant derived protein products is provided. The method includes extraction and purification of plant protein fractions, which may be used for food consumption and/or feed for animals. A plant protein juice is extracted from a green plant material, and used for production of a purified functional 'white' food protein product and/or a 'green' feed protein product.

Classes IPC  ?

• A23J 1/00 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc
• A23J 3/14 - Protéines végétales
• A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
• A23K 20/147 - Dérivés polymériques, p. ex. peptides ou protéines
• B01D 61/14 - UltrafiltrationMicrofiltration

Abrégé

Disclosed is an energy harvester for generating electric energy from an external vibratory force, such as a vibratory force caused by movement of a part of a living human or animal. The energy harvester has a compartment (CMP1, CMP2) with wall element(s) forming a cavity inside. At least one wall element of the compartment has a piezoelectric element connected to an electric output terminal. An impact object (BL) is positioned inside the cavity of the compartment. The impact object is configured to move inside the cavity and to generate an impact on a surface of the wall element(s), so as to cause the piezo-electric element to generate an electric output on the electric output terminal. The compartment may have a cubic shape, e.g. made of a single piezoelectric element folded into shape, e.g. a two-layer piezoelectric element. The impact object may be a metal or ceramics object with a spherical shape. Especially, the energy harvester may be used to power an implantable medical device, e.g. an intra-cardiac pacemaker. An energy harvester housing within an intra-cardiac pacemaker has been tested to be sufficient for powering the pacemaker stimulation circuit by the vibratory force caused by heartbeats.

Classes IPC  ?

• H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers
• A61N 1/378 - Alimentation en courant électrique

Abrégé

The present invention relates inter alia to a hydraulic device which may be used as a hydraulic transformer. The hydraulic device comprising a housing, a first tubular cavity and a second tubular cavity both being provided within the housing. A piston structure is reciprocatable arranged within the housing and comprises a first piston and a second piston; wherein the first piston divides the first cavity into two chambers, and the second piston divides the second cavity into two chambers. Fluid passages for individually exchanging fluid between the chambers and the exterior of the housing are provided and each fluid passage comprising a controllable shut-off valve so as to provide the reciprocating movement of the piston structure by exchanging fluid between exterior and the two chambers of the first cavity, and said hydraulic transformed being configured to control the shut-off valves to selectively be in a closed state or in an open state.

Classes IPC  ?

• F15B 11/02 - Systèmes comportant essentiellement des moyens particuliers pour commander la vitesse ou la puissance d'un organe de sortie
• F15B 11/028 - Systèmes comportant essentiellement des moyens particuliers pour commander la vitesse ou la puissance d'un organe de sortie pour régler la puissance

Abrégé

The present invention provides a power module, especially configured for Medium Voltage (MV) applications. The power module comprises an electrically non- conductive substrate with first and second electrically conductive pads connected to respective external terminals. The first conductive pad is configured for connection to an electric high voltage (HV) potential, such as in the MV range, e.g. 15 kV, and the second conductive pad is configured for connection to electric ground. A semiconductor chip, such as a Silicon Carbide based chip, is directly secured to the first or the second conductive pad. At least a first electrically conductive guard structure is arranged on the upper surface of the non-conductive substrate so as to form a closed ring around the first conductive pad. This first guard structure is configured for electric connection to an electrical potential between electric ground and the HV potential, such as an electric potential of at least 0.5 times the HV potential, such as 0.7-0.9 times the HV potential. Preferred embodiments illustrate how a voltage divider structure can be integrated into the power module to provide the optimal electric potential for the guard structure to give optimal reduction of maximum electric field in the trench.

Classes IPC  ?

• H01L 23/24 - Matériaux de remplissage caractérisés par le matériau ou par ses propriétes physiques ou chimiques, ou par sa disposition à l'intérieur du dispositif complet solide ou à l'état de gel, à la température normale de fonctionnement du dispositif
• H01L 23/373 - Refroidissement facilité par l'emploi de matériaux particuliers pour le dispositif
• H01L 23/62 - Protection contre l'excès de courant ou la surcharge, p. ex. fusibles, shunts
• H01L 25/07 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans la sous-classe

Abrégé

The present invention relates to compounds of Non-Ribosomal Peptide Synthetase and methods of analysing them. In particular the present invention relates to the use of these compounds in vaccines and antigen-binding molecules targeting these compounds.

Classes IPC  ?

• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• C07K 14/37 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons
• C12N 15/80 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons

Abrégé

The present invention concerns a planar winding assembly for power applications, said assembly comprising a frame accommodating a stack of a plurality of printed circuit boards (PCBs), each comprising at least one conductive winding on the PCB, wherein the stack comprises an uppermost first PCB comprising an electrically insulating layer having a top surface and a bottom surface, where the bottom surface is provided with a conductive winding having a first winding pattern; at least one second PCB comprising an electrically insulating layer having a top surface and a bottom surface with conductive windings thereon, where the top surface is provided with the first winding pattern and the bottom surface is provided with a second winding pattern corresponding to the first winding pattern; a lowermost first PCB, which is similar to the uppermost first PCB but positioned with the winding facing upwards; means for holding the plurality of PCBs tightly against each other in the stacked configuration, and the frame encompasses the stack of PCBs. The invention further concerns a method of manufacturing a planar winding assembly for high-power applications.

Classes IPC  ?

• H01F 17/00 - Inductances fixes du type pour signaux
• H01F 17/04 - Inductances fixes du type pour signaux avec noyau magnétique
• H01F 27/28 - BobinesEnroulementsConnexions conductrices
• H01F 27/30 - Fixation ou serrage de bobines, d'enroulements ou de parties de ceux-ci entre euxFixation ou montage des bobines ou enroulements sur le noyau, dans l'enveloppe ou sur un autre support

Abrégé

The present disclosure provides inhibitory nucleic acids, compositions comprising the inhibitory nucleic acids, and methods of using the inhibitory nucleic acids to treat various disorders.

Classes IPC  ?

• A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
• A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

The present invention relates to inter alia to a conductor having at least two windings where each of the two windings preferably has layered configuration of turns, where each layer of a winding preferably is serially connected. Further, layers are typically distanced from each other, preferably by use of layer spacers, which preferably provide a void, or a number of voids, in between each layers. Conductors according to the present invention have shown to lessen, such as reducing parasitic capacitance.

Classes IPC  ?

• H01F 27/34 - Moyens particuliers pour éviter ou réduire les effets électriques ou magnétiques indésirables, p. ex. pertes à vide, courants réactifs, harmoniques, oscillations, champs de fuite
• H01F 1/153 - Alliages métalliques amorphes, p. ex. métaux vitreux
• H01F 5/06 - Isolement des enroulements
• H01F 27/00 - Détails de transformateurs ou d'inductances, en général
• H01F 27/32 - Isolation des bobines, des enroulements, ou de leurs éléments

Abrégé

COVID-19 is treated with antisense oligonucleotides (ASOs) targeting SARS-CoV-2 viral RNAs or human ACE2 RNA.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

The present document discloses a computer-implemented method for non-invasive estimation of Pulmonary Hypertension, PH, from heart sound signals, comprising the steps: receiving a sound signal acquired from a beating heart of a subject over a predetermined time period; generating one or more 2D feature maps comprising a 2D feature map with the received sound signal where a first axis of the map is arranged over time and a second axis of the map is arranged over individual heartbeats; applying a pre-trained neural network to relate the generated one or more 2D feature maps with a training dataset of previously acquired and generated training 2D feature maps of a PH subject group and a non-PH subject group, thus to obtain an indicator of the presence of Pulmonary Hypertension. It further discloses a training method of said neural network and a system.

Classes IPC  ?

• A61B 7/04 - Stéthoscopes électriques
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 8/02 - Mesure du pouls ou du rythme cardiaque
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux

Abrégé

The present invention relates to a computer-implemented method for planning laser processing of one or more elements into one or more final elements, such as planning a process of creating a final element from a sheet metal by creating a 5 model of both the sheet metal to be processed and the final element and determining a plurality of processing steps to create said final element. The method is based on a plurality of rules for taking into account, how to process the element by a plurality of processing steps, said processing steps comprising laser process specifications and generating at least a first set of instructions for an 10 associated laser processing device.

Classes IPC  ?

• G05B 19/4097 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de données de conception pour commander des machines à commande numérique [CN], p. ex. conception et fabrication assistées par ordinateur CFAO

Abrégé

The present invention relates to a device (1) and a method for sensing vibrations in a human's skin (2) emanating from blood flowing in a natural or artificial blood vessel or an arteriovenous fistula (AVF) (3) located below the skin. The device comprises a sensor (4), a controller (5), a transmitter (6), and an electrical power source (7). In particular, the invention relates to such a device that is configured to be fastened to the human and carried around by the human during use of the device. The measured signals are analysed, and if the blood flow is below a pre- selected blood flow threshold, an alarm signal is issued to warn e.g. a responsible medical doctor that there is a need for further assessment.

Classes IPC  ?

• A61B 7/04 - Stéthoscopes électriques
• A61B 7/00 - Instruments d'auscultation
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/026 - Mesure du débit sanguin
• A61B 5/0295 - Mesure du débit sanguin utilisant la pléthysmographie, c.-à-d. par mesure des variations du volume d'une partie du corps induites par la circulation du sang qui traverse cette partie, p. ex. pléthysmographie par impédance

Abrégé

The invention relates to a method of manufacturing a composite component with continuous fibre reinforcement and having a reinforced hole. The hole is reinforced by incorporation of at least one reinforcing element (1) into a layered arrangement of continuous fibres. The reinforcing element comprises a circumferential member (2) with a through-going first hole (9) and a plurality of continuous element fibres (3). The at least one reinforcing element (1) is arranged in an overlapping and/or sandwiching engagement with the layered arrangement so that the first hole is arranged within and aligned with a second hole (8) to be reinforced. Hereby an externally force applied to the reinforced hole during use of the component is distributed over a larger region of the material around the hole. Thereby the component can be joined to another part e.g. by a bolted connection which allows for disassembly that would not have been possible if they were joined by adhesive joining.

Classes IPC  ?

• B29C 70/68 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts en incorporant ou en surmoulant des parties préformées, p. ex. des inserts ou des couches
• B29C 70/70 - Enrobage intégral des inserts

Abrégé

The invention relates to a screw pile (100) adapted for being installed in the ground for providing foundation for a construction (800) or a like, said screw pile comprising an elongated body (200), wherein at least one of the upper part (210), middle part (220) or lower part (230) of the elongated body comprises one or more threaded portions (300), and wherein at least a portion of the volume of the screw pile is concrete (400), said portion of concrete being 50% or more of the volume of the screw pile. In some embodiments, only the lower part of the screw pile has a threaded portion and is made of metal, while an elongated shaft is made of at least 70% concrete. Furthermore, the invention relates to a method of manufacturing a screw pile, said method comprising at least the steps of: providing a mold (600), providing a wet concrete mixture (700) in a liquid form, optionally, providing reinforcement (500), preferably being bars, wires or spirals, optionally, inserting the reinforcement into the concrete mixture, filling the mold with the concrete mixture.

Classes IPC  ?

• E02D 5/24 - Pieux préfabriqués
• E02D 5/30 - Pieux préfabriqués en béton ou béton armé ou en acier et béton
• E02D 5/56 - Pieux à vis
• E02D 7/22 - Mise en place par vissage

Abrégé

The present invention relates to a method for installation and validation of a screw pile (100) being installed in the ground, said method comprising the steps of: placing at least one screw pile at a location, providing means for screwing (200) the at least one screw pile into the ground, starting screwing the at least one screw pile into the ground by the means for screwing, during the process of screwing measuring at least a set of installation parameters comprising: torsion and/or torque and penetration depth, generating an output indicative of said installation parameters, and providing an installation validation, e.g. an installation validation document or file, of the at least one screw pile. In some embodiments the method comprises to stop screwing the screw pile into the ground when predetermined thresholds of installation parameters are reached. In some embodiments the method comprises generating a data on how the screw pile was installed, e.g. screw direction and rotation versus penetration depth data, e.g. to be included as part of the installation validation. Furthermore, the present invention relates to an installation validation document for at least one screw pile installed in the ground, moreover the invention relates to a computer program.

Classes IPC  ?

• E02D 5/56 - Pieux à vis
• E02D 7/22 - Mise en place par vissage

Abrégé

The present invention provides a power module arranged to receive a DC electric input signal at first and second connection terminals (A, B), and to output an AC electric output signal at third and fourth connection terminals (C, D). A set of capacitors (CAP1, CAP2) are connected between respective sets of connection terminals (A, B, C, D). Two inductors (L1, L2) are connected at least to respective connection terminals (C, D), such as the first inductor (L1) being connected between on set of connection terminals (A, C), and the second inductor (L2) being connected between another set of connection terminals (B, D). A switch network (SWN) with at least one electrically controllable bidirectional two-quadrant switch (s1), is connected between at least two of the four connection terminals (A, B, C, D). The at least one witch (s1) is arranged for being controlled according to a switching cycle, so as to provide an average voltage (V1) of zero across the first inductor (L1) over one switching period of the switching cycle, and to provide an average voltage (V2) of zero across the second inductor (L2) over one switching period. The power module is simple, and can be implemented with only one single switch per module. A DC to AC power converter can be build of a number of interconnected power modules, and such power converter can be designed to provide an AC output voltage in the kV range at a power in the kW range, at a frequency of up to such as 40 MHz.

Classes IPC  ?

• H02M 1/00 - Détails d'appareils pour transformation
• H02M 7/48 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande
• H05B 6/48 - Circuits
• H02M 7/49 - Combinaison des formes de tension de sortie d'une pluralité de convertisseurs
• H02M 7/483 - Convertisseurs munis de sorties pouvant chacune avoir plus de deux niveaux de tension
• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs

Abrégé

The invention relates to a load-bearing test apparatus adapted to test the load-bearing capacity of an associated pile installed in the ground, preferably an associated screw pile, the load-bearing test apparatus comprising: a load carrier having at least one main protrusion and at least one receiving portion, a load being positioned on the load carrier or being an integrated part of the carrier, preferably being a plurality of load plates, a shaft adapted for allowing the load carrier to slide up and down in a vertical direction, at least one connecting piece for attachable connecting the load carrier to the associated pile, and a locking system. Furthermore, the invention relates to a method for testing the load-bearing capacity of a pile installed in the ground.

Classes IPC  ?

• E02D 5/56 - Pieux à vis
• E02D 7/22 - Mise en place par vissage
• E02D 33/00 - Test des fondations
• G01M 7/08 - Test de résistance au choc

Abrégé

The present invention relates to method for cutting and shaping and/or bending a metal element into a final element using laser means, the method comprising providing data containing a final model of the final element and providing a set of instructions as to how to process the final element from the metal element, measure the processing and provide at least a second set of instructions based on feedback, such as geometrical measurements during said processing, so as to create a final element.

Classes IPC  ?

• G05B 19/18 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique

Abrégé

The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: —Providing input signals, —Using said input signals as input variables of a musculoskeletal model, —Determining feedback signals using said musculoskeletal model, —Transmitting said feedback signals to said user of said orthopedic device.

Classes IPC  ?

• A61F 2/72 - Commandes bioélectriques, p. ex. myoélectriques
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Disclosed is an energy harvester for generating electric energy from an external vibratory force, such as a vibratory force caused by movement of a part of a living human or animal. The energy harvester has a compartment (CMP1, CMP2) with wall element(s) forming a cavity inside. At least one wall element of the compartment has a piezoelectric element connected to an electric output terminal. An impact object (BL) is positioned inside the cavity of the compartment. The impact object is configured to move inside the cavity and to generate an impact on a surface of the wall element(s), so as to cause the piezoelectric element to generate an electric output on the electric output terminal. The compartment may have a cubic shape, e.g. made of a single piezoelectric element folded into shape, e.g. a two-layer piezoelectric element. The impact object may be a metal or ceramics object with a spherical shape. Especially, the energy harvester may be used to power an implantable medical device, e.g. an intra-cardiac pacemaker. An energy harvester housing within an intra-cardiac pacemaker has been tested to be sufficient for powering the pacemaker stimulation circuit by the vibratory force caused by heartbeats.

Classes IPC  ?

• H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
• A61N 1/378 - Alimentation en courant électrique

Abrégé

The present invention relates to glass-based substrates and articles that can be hydrated under special circumstances to increase their crack resistance and induce self-healing, and to processes for their production.

Classes IPC  ?

• C03C 3/083 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant de l'oxyde d'aluminium ou un composé du fer
• C03C 3/085 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant de l'oxyde d'aluminium ou un composé du fer contenant un oxyde d'un métal divalent
• C03C 3/091 - Compositions pour la fabrication du verre contenant de la silice avec 40 à 90% en poids de silice contenant du bore contenant de l'aluminium
• C03C 23/00 - Autres traitements de surface du verre, autre que sous forme de fibres ou de filaments
• C03C 21/00 - Traitement du verre, autre que sous forme de fibres ou de filaments, par diffusion d'ions ou de métaux en surface

Abrégé

The present invention relates inter alia to a hydraulic device which may be used as a hydraulic transformer. The hydraulic device comprising a housing, a first tubular cavity and a second tubular cavity both being provided within the housing. A piston structure is reciprocatable arranged within the housing and comprises a first piston and a second piston; wherein the first piston divides the first cavity into two chambers, and the second piston divides the second cavity into two chambers. Fluid passages for individually exchanging fluid between the chambers and the exterior of the housing are provided and each fluid passage comprising a controllable shut-off valve so as to provide the reciprocating movement of the piston structure by exchanging fluid between exterior and the two chambers of the first cavity, and said hydraulic transformed being configured to control the shut-off valves to selectively be in a closed state or in an open state.

Classes IPC  ?

• F15B 3/00 - Amplificateurs ou convertisseurs de pression de fluide, p. ex. échangeurs de pressionTransmission de la pression d'un système à fluide à un autre, sans contact entre les fluides
• F15B 11/032 - Systèmes comportant essentiellement des moyens particuliers pour commander la vitesse ou la puissance d'un organe de sortie pour régler la puissance au moyen de convertisseurs de pression de fluide
• F04F 13/00 - Échangeurs de pression
• F15B 11/036 - Systèmes comportant essentiellement des moyens particuliers pour commander la vitesse ou la puissance d'un organe de sortie pour régler la puissance au moyen de servomoteurs comportant plusieurs chambres de travail

Abrégé

A front-end device for monitoring operation of an associated electric power device with semiconductor power switches generating a power output, e.g. a three-phase power output. The front-end device has input terminals arranged for connection to the electric phase(s) of the power output of the associated electric power device, and an electric circuit connected to the input terminals and connected to at set of output terminals. The electric circuit has a passive interconnection comprising electric semiconductor switches and diodes. The electric circuit serves to electrically block any high voltage component from the input terminals from reaching the output terminals, while allowing an on-state voltage of at least one semiconductor power switch in the associated electric power device to pass to the at least two output terminals. The front-end allows low voltage equipment to be connected to its output terminals for determining an on-state voltage of switches of the electric power device. Especially, embodiments with self-powered reference voltage circuits provided by zener diodes allow compact low cost versions for use in e.g. portable test equipment or as part of permanently installed health condition monitoring of power devices. The front-end device can be used as a simple and low cost solution for non-invasive health condition monitoring of power devices, e.g. power converters in such as power electric generation system or electric vehicles. Such monitoring allows predictive maintenance to be performed to avoid any faults in the power device that may cause permanent damages.

Classes IPC  ?

• G01R 31/26 - Test de dispositifs individuels à semi-conducteurs
• G01R 31/327 - Tests d'interrupteurs de circuit, d'interrupteurs ou de disjoncteurs

Abrégé

The invention provides a non-invasive tongue based with a tongue sensor device arranged for position in the oral cavity of the user. A sensor panel to be placed on an upper part of the oral cavity of the user, and having a 2D array of activation zones and related electric coils. A guide structure, e.g. a metal or polymer frame, carries a ferrous or metallic activation unit movably in a plane upon manipulation by the user's tongue. This allows the user to position the activation unit in relation the activation zones. The guide structure allows the activation unit to move also perpendicular to the plane, to allow the user's tongue to manipulate the activation unit near one activation zone for activation of the activation zone. An electronic circuit inductively senses activation of any one or more of the plurality of activation zones and related electric coils and generates an output accordingly, e.g. a wireless RF output. E.g. a frame structure of metal wires or bars can be used to implement the guide structure, thus allowing the activation unit, e.g. a metal sphere or cylinder, to form an integrated part of the rather than being mounted in an invasive way on the user's tongue.

Classes IPC  ?

• A61F 4/00 - Procédés ou dispositifs permettant à des patients ou à des personnes handicapées de commander un appareil ou un dispositif ne faisant pas partie du corps
• G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur

Abrégé

The present invention provides antisense oligonucleotides directed against immune checkpoints and methods and compositions of using such antisense oligonucleotides for the treatment of cancer.

Classes IPC  ?

• A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 35/00 - Agents anticancéreux

Abrégé

The invention relates to a hand orthosis (1) for assisting the movements of a user's hand. The hand orthosis comprises a soft glove (2) adapted to receive at least a part of the user's hand with finger sections of the glove receiving each of the user's fingers. It further comprises at least one actuator box (3), and a power transmission (4) for transferring forces from the at least one actuator box to different parts of the glove via exo-tendons (5). The exo-tendons are arranged on a dorsal side, on a palmar side, or on both a dorsal side and a palmar side of the glove. The exo-tendons are arranged so that the glove can assist flexion, extension, or both extension and flexion of the fingers, respectively and so that the exo-tendons act on the fingers to produce motion that mimics the movement of a human hand. The hand orthosis provides different grasp types, self- adaptation of the fingers' motion to the shape of the object, and physiologically appropriate distribution of finger forces.

Classes IPC  ?

• A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles

Abrégé

The present invention relates to inter alia to a conductor having at least two windings where each of the two windings preferably has layered configuration of turns, where each layer of a winding preferably is serially connected. Further, layers are typically distanced from each other, preferably by use of layer spacers, which preferably provide a void, or a number of voids, in between each layers. Conductors according to the present invention have shown to lessen, such as reducing parasitic capacitance.

Classes IPC  ?

• H01F 37/00 - Inductances fixes non couvertes par le groupe
• H01F 5/02 - Bobines d'induction enroulées sur des supports non magnétiques, p. ex. mandrins
• H01F 17/06 - Inductances fixes du type pour signaux avec noyau magnétique avec noyau refermé sur lui-même, p. ex. tore
• H01F 27/28 - BobinesEnroulementsConnexions conductrices
• H01F 27/29 - BornesAménagements de prises
• H01F 27/32 - Isolation des bobines, des enroulements, ou de leurs éléments

Abrégé

The proposed technology relates to the quantifying of cardiorespiratory fitness. It includes the obtaining (102) of a seismocardiogram (SCG) recorded with an accelerometer (14) configured to measure accelerations and vibrations of the chest wall of a person (18) caused by myocardial movement. Properties of a first signal feature (AC) in the seismocardiogram (SCG) are determined (104), wherein the first signal feature (AC) corresponds to the aortic valve closure (AC) of a heartbeat. A measure indicating cardiorespiratory fitness (VO2 max) is then determined (106) based on the properties of first signal feature (AC).

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques

Abrégé

A method is provided for determining pulmonary embolism and/or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

The invention relates to a curved spherical scissors linkage mechanism (1) comprising at least four linkage elements (2) each having a first end (3) and a second end (4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombi or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion (RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The spherical scissors linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end. It further comprises actuator means as control means.

Classes IPC  ?

• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs
• B25J 9/00 - Manipulateurs à commande programmée
• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage

Abrégé

The present invention relates to a method for identification of tissue hypoxia from measurements of acid-base and oxygenation status from venous and/or arterial blood.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

The invention relates to a method of manufacturing a composite component with continuous fibre reinforcement and having a reinforced hole. The hole is reinforced by incorporation of at least one reinforcing element (1) into a layered arrangement of continuous fibres. The reinforcing element comprises a circumferential member (2) with a through-going first hole (9) and a plurality of continuous element fibres (3). The at least one reinforcing element (1) is arranged in an overlapping and/or sandwiching engagement with the layered arrangement so that the first hole is arranged within and aligned with a second hole (8) to be reinforced. Hereby an externally force applied to the reinforced hole during use of the component is distributed over a larger region of the material around the hole. Thereby the component can be joined to another part e.g. by a bolted connection which allows for disassembly that would not have been possible if they were joined by adhesive joining.

Classes IPC  ?

• B29C 70/20 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts comprenant uniquement des renforcements, p. ex. matières plastiques auto-renforçantes des renforcements fibreux uniquement caractérisées par la structure des renforcements fibreux utilisant des fibres de grande longueur, ou des fibres continues orientées dans une seule direction, p. ex. mèches ou autres fibres parallèles
• B29C 70/30 - Façonnage par empilage, c.-à-d. application de fibres, de bandes ou de feuilles larges sur un moule, un gabarit ou un noyauFaçonnage par pistolage, c.-à-d. pulvérisation de fibres sur un moule, un gabarit ou un noyau
• B29C 70/76 - Moulage sur les bords ou les extrémités de la partie préformée
• B29C 70/84 - Moulage de matière sur des parties préformées à réunir
• B29C 70/86 - Incorporation dans des couches de renforcement imprégnées cohérentes
• B29C 70/32 - Façonnage par empilage, c.-à-d. application de fibres, de bandes ou de feuilles larges sur un moule, un gabarit ou un noyauFaçonnage par pistolage, c.-à-d. pulvérisation de fibres sur un moule, un gabarit ou un noyau sur un moule, un gabarit ou un noyau rotatifs
• B29C 70/38 - Empilage automatisé, p. ex. utilisant des robots, par application de filaments selon des modèles prédéterminés

Abrégé

COVID-19 is treated with antisense oligonucleotides (ASOs) targeting SARS-CoV-2 viral RNAs or human ACE2 RNA.

Classes IPC  ?

• A61K 35/76 - VirusParticules sous-viralesBactériophages
• A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
• C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• C12N 15/86 - Vecteurs viraux

Abrégé

The invention deals with a method for controlling an orthopedic device, the method comprising the following steps of: - Providing input signals, - Using said input signals as input variables of a musculoskeletal model, - Determining feedback signals using said musculoskeletal model, - Transmitting said feedback signals to said user of said orthopedic device.

Classes IPC  ?

• A61F 2/54 - Bras ou mains artificiels ou leurs parties
• A61F 2/60 - Jambes ou pieds artificiels ou leurs parties
• A61F 2/72 - Commandes bioélectriques, p. ex. myoélectriques
• A61F 2/50 - Prothèses non implantables dans le corps
• A61F 2/68 - Moyens d'actionnement ou de commande

Abrégé

The present invention relates to method for cutting and shaping and/or bending a metal element into a final element using laser means, the method comprising providing data containing a final model of the final element and providing a set of instructions as to how to process the final element from the metal element, measure the processing and provide at least a second set of instructions based on feedback, such as geometrical measurements during said processing, so as to create a final element.

Classes IPC  ?

• G05B 19/4097 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de données de conception pour commander des machines à commande numérique [CN], p. ex. conception et fabrication assistées par ordinateur CFAO

Abrégé

The present invention relates to a computer-implemented method for planning laser processing of one or more elements into one or more final elements, such as planning a process of creating a final element from a sheet metal by creating a 5 model of both the sheet metal to be processed and the final element and determining a plurality of processing steps to create said final element. The method is based on a plurality of rules for taking into account, how to process the element by a plurality of processing steps, said processing steps comprising laser process specifications and generating at least a first set of instructions for an 10 associated laser processing device.

Classes IPC  ?

• G05B 19/4097 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de données de conception pour commander des machines à commande numérique [CN], p. ex. conception et fabrication assistées par ordinateur CFAO

Abrégé

A front-end device for monitoring operation of an associated electric power device with semiconductor power switches generating a power output, e.g. a three-phase power output. The front-end device has input terminals arranged for connection to the electric phase(s) of the power output of the associated electric power device, and an electric circuit connected to the input terminals and connected to at set of output terminals. The electric circuit has a passive interconnection comprising electric semiconductor switches and diodes. The electric circuit serves to electrically block any high voltage component from the input terminals from reaching the output terminals, while allowing an on-state voltage of at least one semiconductor power switch in the associated electric power device to pass to the at least two output terminals. The front-end allows low voltage equipment to be connected to its output terminals for determining an on-state voltage of switches of the electric power device. Especially, embodiments with self-powered reference voltage circuits provided by zener diodes allow compact low cost versions for use in e.g. portable test equipment or as part of permanently installed health condition monitoring of power devices. The front-end device can be used as a simple and low cost solution for non-invasive health condition monitoring of power devices, e.g. power converters in such as power electric generation system or electric vehicles. Such monitoring allows predictive maintenance to be performed to avoid any faults in the power device that may cause permanent damages.

Classes IPC  ?

• G01R 31/26 - Test de dispositifs individuels à semi-conducteurs
• G01R 31/327 - Tests d'interrupteurs de circuit, d'interrupteurs ou de disjoncteurs
• H03K 17/00 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts
• H02M 1/32 - Moyens pour protéger les convertisseurs autrement que par mise hors circuit automatique

Abrégé

Existing modular multi-level converters can be bulky because their submodule capacitors are comparatively large. To address this shortcoming in the state of the art, the present disclosure provides electronic power circuits and their use in power converters and in modular multi-level converters. The disclosed power circuits include connection terminals connected to electrically controllable bidirectional two-quadrant switches and to capacitors, as well as inductors that are magnetically coupled and operate to equalize voltages of the capacitors.

Classes IPC  ?

• H02M 7/483 - Convertisseurs munis de sorties pouvant chacune avoir plus de deux niveaux de tension
• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs

Abrégé

An active two-terminal inductor device with a controllable inducitance based on an inductance value input L_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value inductor component L1. Based on sampling of at least a voltage or a current in connection with the inductor component L1, the algorithm controls the power converter PCV to provide a resulting inductance across the external terminals A, B which serves to match the inductance value input L_I.

Classes IPC  ?

• H01F 7/06 - Électro-aimantsActionneurs comportant des électro-aimants
• H01F 7/20 - Électro-aimantsActionneurs comportant des électro-aimants sans armature
• H03K 17/687 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs à semi-conducteurs les dispositifs étant des transistors à effet de champ

Abrégé

The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

Classes IPC  ?

• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice

Abrégé

The invention relates to a hand orthosis (1) for assisting the movements of a user's hand. The hand orthosis comprises a soft glove (2) adapted to receive at least a part of the user's hand with finger sections of the glove receiving each of the user's fingers. It further comprises at least one actuator box (3), and a power transmission (4) for transferring forces from the at least one actuator box to different parts of the glove via exo-tendons (5). The exo-tendons are arranged on a dorsal side, on a palmar side, or on both a dorsal side and a palmar side of the glove. The exo-tendons are arranged so that the glove can assist flexion, extension, or both extension and flexion of the fingers, respectively and so that the exo-tendons act on the fingers to produce motion that mimics the movement of a human hand. The hand orthosis provides different grasp types, self- adaptation of the fingers' motion to the shape of the object, and physiologically appropriate distribution of finger forces.

Classes IPC  ?

• A61F 2/58 - CoudesPoignets
• A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles

Abrégé

An active two-terminal capacitor device with a controllable capacitance based on a capacitance value input C_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value capacitor component CI. Based on sampling of at least the voltage across the capacitor component CI, the algorithm controls the power converter PCV to provide a resulting capacitance across the external terminals A, B which serves to match the capacitance value in ut C_I.

Classes IPC  ?

• H02M 3/158 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs avec commande automatique de la tension ou du courant de sortie, p. ex. régulateurs à commutation comprenant plusieurs dispositifs à semi-conducteurs comme dispositifs de commande finale pour une charge unique
• G06F 1/26 - Alimentation en énergie électrique, p. ex. régulation à cet effet
• H02M 7/00 - Transformation d'une puissance d'entrée en courant alternatif en une puissance de sortie en courant continuTransformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif
• H02M 7/5387 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur dans une configuration en pont

Abrégé

A method is provided for determining pulmonary embolism and/or increased risk thereof in a human being, comprising collecting a sample of exhalation air from said human being and determining the presence or absence in said exhaled air of one or more biomarkers associated with pulmonary embolism. Additionally, a kit that comprises the means for detecting at least one biomarker associated with pulmonary embolism or risk thereof is provided.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The proposed technology relates to the quantifying of cardiorespiratory fitness. It includes the obtaining (102) of a seismocardiogram (SCG) recorded with an accelerometer (14) configured to measure accelerations and vibrations of the chest wall of a person (18) caused by myocardial movement. Properties of a first signal feature (AC) in the seismocardiogram (SCG) are determined (104), wherein the first signal feature (AC) corresponds to the aortic valve closure (AC) of a heartbeat. A measure indicating cardiorespiratory fitness (VO2max) is then determined (106) based on the properties of first signal feature (AC).

Classes IPC  ?

• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

Abrégé

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

The invention relates to a curved spherical scissors linkage mechanism (1) comprising at least four linkage elements (2) each having a first end (3) and a second end (4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombus or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion (RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The spherical scissors linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end. It further comprises actuator means as control means.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée
• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs
• B25J 18/00 - Bras

Abrégé

The present invention relates to a method for identification of tissue hypoxia from measurements of acid-base and oxygenation status from venous and/or arterial blood.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux

Abrégé

The present invention relates to a computer-implemented method for identification of the degree to which a transient disturbance in ventilation causes changes in measurement of arterial acid-base status.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux

Abrégé

A curved scissor linkage mechanism (1) includes at least four linkage elements (2) each having a first end (3) and a second end (4). The linkage elements are arranged to form sides of one or more rhombi or parallelograms. Each linkage element is rotationally connected to another linkage elements via a revolute joint (5) at the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at the second end. The linkage elements are configured so that the axes of each joint coincide at one common remote centre of motion. The mechanism is connectable to a first external member (7) at a proximal end and is rotationally connectable to a second external member (9) at an opposite distal end to obtain three DOFs. The scissor linkage mechanism may further include a motion controlling mechanism.

Classes IPC  ?

• B25J 18/00 - Bras
• A61B 34/30 - Robots chirurgicaux
• A61B 90/50 - Supports pour instruments chirurgicaux, p. ex. bras articulés
• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• A61H 3/00 - Appareils pour aider des personnes handicapées à marcher
• B25J 9/00 - Manipulateurs à commande programmée
• F16H 21/54 - Transmissions ne comportant essentiellement que des tringles ou des leviers, avec ou sans glissières avec mouvements dans les trois dimensions pour convertir un mouvement oscillant en mouvement alternatif et vice versa ou pour transmettre ces mouvements

Abrégé

The invention is a new design of a compliant revolute joint mechanism, which has multiple configurations exhibiting variable stiffness performance. The joint mechanism provides compliance between its input and output shafts. Variable stiffness performance, such as soft spring, hard spring, in addition to linear spring, can be achieved by changing the mechanism configuration which is based on the wrapping pattern of elastic material, replacing the elastic material of different stiffness, or tuning their pretention force. The invention is designed with a compact structure. The new joint can be integrated into electric motors to build compliant actuators in assistive exoskeletons, rehabilitation robots and other robots where a safe human-robot interaction is concerned. The innovation can also be applied as a new coupling device, which is commonly used in motion transmissions.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée
• B25J 17/02 - Joints articulés
• B25J 19/02 - Dispositifs sensibles
• B25J 13/08 - Commandes pour manipulateurs au moyens de dispositifs sensibles, p. ex. à la vue ou au toucher
• B25J 19/06 - Dispositifs de sécurité
• F16D 3/62 - Accouplements extensibles, c.-à-d. avec moyens permettant le mouvement entre parties accouplées durant leur entraînement avec pièces d'accouplement reliées par un ou plusieurs organes intermédiaires comportant des tringles de poussée ou de traction reliées à la fois aux deux parties les tringles ou leurs fixations étant élastiques

Abrégé

The present subject matter relates to antenna systems, devices, and methods that are designed to avoid the degradation of the end-fire radiation pattern of the array when a piece of metal is added obstructing the direction of the main beam. A parasitic radiator is positioned in proximity to the blocking structure and configured to couple at least part of the reflected radiation pattern and radiate toward the desired end-fire direction.

Classes IPC  ?

• H04B 7/0426 - Distribution de puissance
• H01Q 21/29 - Combinaisons d'unités d'antennes de types différents interagissant entre elles pour donner une caractéristique directionnelle désirée
• H04B 7/06 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission
• H01Q 1/24 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets avec appareil récepteur
• H01Q 1/36 - Forme structurale pour éléments rayonnants, p. ex. cône, spirale, parapluie
• H01Q 5/392 - Combinaison d’éléments alimentés et d’éléments passifs les éléments passifs étant bibandes ou multibandes
• H01Q 7/00 - Cadres ayant une distribution du courant sensiblement uniforme et un diagramme de rayonnement directif perpendiculaire au plan du cadre

Abrégé

An electric converter for converting AC or DC input into an electric AC or DC output. A swap circuit with controllable electric switches serves to selectively swap connection of a plurality of DC power banks (DCBs) between an input terminal and an output terminal, thus selectively connecting the DCBs to an electric source or an electric load. The DCBs are formed as series of interconnected submodules (SMs) each having one or more electric energy storage elements (ESEs) and a switching circuit for selectively by-passing or connecting the ESEs. The ESEs can be capacitors, batteries, super capacitors, or a combination of these. By properly controlling the swap circuit and the switching of the SMs, such as by taking into account the dead-time for the electric switches involved, the converter can be used for DC-AC, DC-DC, AC-DC, or AC-AC conversion, allowing multilevel output. It can in some embodiments eliminate the need for an unfolding converter, and the converter provides a rather simple and efficient topology, suitable e.g. for connection of a DC input from a photovoltaic elements to an AC electric grid.

Classes IPC  ?

• H02M 3/07 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des résistances ou des capacités, p. ex. diviseur de tension utilisant des capacités chargées et déchargées alternativement par des dispositifs à semi-conducteurs avec électrode de commande
• H02M 7/483 - Convertisseurs munis de sorties pouvant chacune avoir plus de deux niveaux de tension
• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs

Abrégé

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The invention relates to a method of determining the laxity of a joint (9, 15) of a human (5) or an animal. The method comprises providing at least one patient-specific geometrical model (1) of at least one bone and/or at least one prosthesis comprised by the joint. Known loads are applied to the joint or to a part of the body connected to the joint, and a series of actual images (16) of the joint are obtained while the loads are applied. Then the at least one patient-specific geometrical model (1) is registered onto the actual images (16). Based thereon relative displacement and/or rotation of the at least one bone and/or at least one prosthesis is calculated as a function of the applied loads, and based thereon a measure of the laxity of the joint is determined. The invention further relates to a system for performing such a method and to a computer readable medium for performing such a method.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 6/03 - Tomographie informatisée
• A61B 8/08 - Applications cliniques

Abrégé

The present invention relates to electronic power circuits and their use in power converters and in modular multi-level converters (MMCs) comprising such power converters.

Classes IPC  ?

• H02M 7/483 - Convertisseurs munis de sorties pouvant chacune avoir plus de deux niveaux de tension
• H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs

Abrégé

The invention relates to a method of controlling thermal stress of a semiconductor chip, the method comprises the steps of: establishing a modular frequency of the semiconductor chip and thereby a thermal profile of the semiconductor chip and establishing a pulsing current controlling the thermal profile of a thermoelectric cooling device thermally connected to the semiconductor chip. Wherein the pulsing current is generated in response to the modular frequency, so that a super cooling period of the thermal profile of the thermoelectric cooling device is at least partly overlapping a temperature increasing period of the thermal profile of the semiconductor chip,anda recovery period of the thermal profile of the thermoelectric cooling device is at least partly overlapping a temperature decreasing period of the thermal profile of the semiconductor chip.

Classes IPC  ?

• H01L 23/38 - Dispositifs de refroidissement utilisant l'effet Peltier
• H01L 35/30 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails fonctionnant exclusivement par effet Peltier ou effet Seebeck caractérisés par les moyens d'échange de chaleur à la jonction
• H01L 35/32 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails fonctionnant exclusivement par effet Peltier ou effet Seebeck caractérisés par la structure ou la configuration de la cellule ou du thermocouple constituant le dispositif

Abrégé

The invention provides a method for generating output filters to a plurality of loudspeakers at respective positions for playback of a plurality of different input signals in respective spatially different sound zones by means of a processor system. The method comprising computing spatio-temporal correlation matrices in response to spatial information, e.g. measured transfer functions, and in response to desired sound pressures in the plurality of sound zones. Joint eigenvalue decomposition of the spatial correlation matrices are then computed, or at least an approximation thereof, to arrive at eigenvectors accordingly. Next, variable span filters a reformed from a linear combination of the eigenvectors in response to a desired trade-off between acoustic contrast and acoustic errors in the sound zones. Finally, output filter for each of the plurality of loudspeakers,for each of the plurality of input signals, in accordance with the variable span filters.The method is applicable also for optimization in one zone, e.g. for room equalization.

Classes IPC  ?

• H04S 7/00 - Dispositions pour l'indicationDispositions pour la commande, p. ex. pour la commande de l'équilibrage

Abrégé

The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice

Abrégé

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

An active two-terminal inductor device with a controllable inducitance based on an inductance value input L_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value inductor component L1. Based on sampling of at least a voltage or a current in connection with the inductor component L1, the algorithm controls the power converter PCV to provide a resulting inductance across the external terminals A, B which serves to match the inductance value input L_I.

Classes IPC  ?

• H02M 1/15 - Dispositions de réduction des ondulations d'une entrée ou d'une sortie en courant continu utilisant des éléments actifs
• H02J 1/02 - Dispositions pour réduire les harmoniques ou les ondulations
• H02J 1/14 - Équilibrage de la charge dans un réseau
• H03K 17/687 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs à semi-conducteurs les dispositifs étant des transistors à effet de champ

Abrégé

An active two-terminal capacitor device with a controllable capacitance based on a capacitance value input C_I. A processor system PRS executes an algorithm which controls a power converter PCV with controllable electric switches connected to the two external terminals A, B along with a fixed value capacitor component CI. Based on sampling of at least the voltage across the capacitor component CI, the algorithm controls the power converter PCV to provide a resulting capacitance across the external terminals A, B which serves to match the capacitance value in ut C_I.

Classes IPC  ?

• H02M 1/15 - Dispositions de réduction des ondulations d'une entrée ou d'une sortie en courant continu utilisant des éléments actifs
• H02J 1/02 - Dispositions pour réduire les harmoniques ou les ondulations
• H02J 1/14 - Équilibrage de la charge dans un réseau
• H03K 17/687 - Commutation ou ouverture de porte électronique, c.-à-d. par d'autres moyens que la fermeture et l'ouverture de contacts caractérisée par l'utilisation de composants spécifiés par l'utilisation, comme éléments actifs, de dispositifs à semi-conducteurs les dispositifs étant des transistors à effet de champ

Abrégé

A method for analyzing a condition of a heart, comprises receiving a plurality of electric signals, which are acquired by non-invasive measurement on the skin of a person or animal, each signal representing electrical activity in a respective region of the heart of the person or animal; calculating a derivative value of each signal at a plurality of time instances; selecting a plurality of the calculated derivative values of a first signal and determining a first point in time of a first event based on the selected derivative values; selecting a plurality of the calculated derivative values of a second signal and determining a second point in time of a second event, corresponding to the first event, based on the selected derivative values of the second signal, and calculating at least one measure based on a difference of the first point in time and the second point in time.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/366 - Détection de complexes QRS anormaux, p. ex. élargissement
• A61N 1/37 - SurveillanceProtection
• A61N 1/362 - Stimulateurs cardiaques
• A61B 5/316 - Modalités, c.-à-d. méthodes diagnostiques spécifiques
• A61B 5/339 - Affichages spécialement adaptés à cet effet

Abrégé

The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.

Classes IPC  ?

• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique

Abrégé

The present invention relates to an air-cooled fuel cell assembly (9) comprising a fuel cell (1) having a membrane electrode assembly disposed between an anode fluid flow plate and a cathode fluid flow plate, said cathode flow plate defining a flow channel for conveying oxidant to the membrane electrode assembly, said flow channel having an inlet and an outlet and said flow channel extending between two opposing perimeters (5a, 5b) of said fuel cell assembly (9), an air pump (2) arranged to generate air flow in said flow channel in a first direction (8), a turbulence inducing device (4) upstream, relative to said first direction (8), of said flow channel, said turbulence inducing device comprising a grid.

Classes IPC  ?

• H01M 8/04089 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration des réactifs gazeux
• H01M 8/04007 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides relatives à l’échange de chaleur
• H01M 8/04014 - Échange de chaleur par des fluides gazeuxÉchange de chaleur par combustion des réactifs
• H01M 8/04746 - PressionDébit
• H01M 8/04701 - Température
• H01M 8/1018 - Matériaux d’électrolyte polymère

Abrégé

A technology for quantifying, or determining an indication of, cardiorespiratory fitness is disclosed. A signal portion is obtained from a signal recorded with an accelerometer placed on the chest of a person. The accelerometer measures accelerations and vibrations of the chest wall of the person caused by myocardial movement. A maximum value is determined in the signal portion, and output information is provided indicating cardiorespiratory fitness based on the maximum value.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The invention relates to a curved scissor linkage mechanism(1)comprising at least four linkage elements(2)each having a first end (3) and a second end(4); the linkage elements are arranged to form sides of one rhombus or parallelogram, or a series, such as a network, of joined rhombi or parallelograms. Each of the linkage elements is rotationally connected to one of the other linkage elements via a revolute joint (5) at or near the first end and is rotationally connected to another one of the other linkage elements via another revolute joint at or near the second end. The linkage elements are shaped, dimensioned and arranged so that the axes of all the revolute joints coincide at one common remote centre of motion(RCM). Furthermore, the mechanism is grounded or connected or connectable to a first external member (7) at a proximal end and is rotationally connected or connectable to a second external member (9) at an opposite distal end. Hereby a spherical linkage mechanism with three DOFs is obtained. The scissor linkage mechanism may further comprise a motion controlling mechanism at the proximal and/or at the distal end.

Classes IPC  ?

• B25J 18/00 - Bras
• B25J 9/00 - Manipulateurs à commande programmée
• F16H 21/00 - Transmissions ne comportant essentiellement que des tringles ou des leviers, avec ou sans glissières
• A61B 34/30 - Robots chirurgicaux
• E04H 15/50 - Moyens de support, p. ex. armatures repliables, p. ex. du type démontable pliables, c.-à-d. avec des charnières ou des gonds du type à ciseaux

Abrégé

Disclosed apparatus and method improve the computational efficiency of encoding and decoding data having erasures according to a maximum distance separable (MDS) code based on a Reed-Solomon code. Thus, n encoded fragments are formed by multiplying k data fragments by an n×k generator matrix for the MDS code. The code is formed by reducing, in the generator matrix to the extent possible, the size of the finite field to which entries belong—in some cases to the base field having only two elements. In this way, unlike codes known in the art, the generator matrix has more than one column whose entries each take values in the finite field having two elements. In some cases, the generator matrix has a column whose entries each take values in one or more intermediate fields between the finite field having two elements and the encoding field.

Classes IPC  ?

• H03M 13/00 - Codage, décodage ou conversion de code pour détecter ou corriger des erreursHypothèses de base sur la théorie du codageLimites de codageMéthodes d'évaluation de la probabilité d'erreurModèles de canauxSimulation ou test des codes
• H03M 13/37 - Méthodes ou techniques de décodage non spécifiques à un type particulier de codage prévu dans les groupes
• G06F 17/16 - Calcul de matrice ou de vecteur
• G06F 9/30 - Dispositions pour exécuter des instructions machines, p. ex. décodage d'instructions
• H03M 13/15 - Codes cycliques, c.-à-d. décalages cycliques de mots de code produisant d'autres mots de code, p. ex. codes définis par un générateur polynomial, codes de Bose-Chaudhuri-Hocquenghen [BCH]
• G06F 7/72 - Méthodes ou dispositions pour effectuer des calculs en utilisant une représentation numérique non codée, c.-à-d. une représentation de nombres sans baseDispositifs de calcul utilisant une combinaison de représentations de nombres codées et non codées utilisant l'arithmétique des résidus

Abrégé

A protocol for use in wireless mesh networks uses helper nodes to improve data flow in the network. The protocol is compatible with traditional mesh network routing algorithms. Techniques, systems, devices, and circuits for implementing the protocol are described.

Classes IPC  ?

• H04W 40/12 - Sélection d'itinéraire ou de voie de communication, p. ex. routage basé sur l'énergie disponible ou le chemin le plus court sur la base de la qualité d'émission ou de la qualité des canaux
• H04L 12/64 - Systèmes de commutation hybrides
• H04W 40/24 - Gestion d'informations sur la connectabilité, p. ex. exploration de connectabilité ou mise à jour de connectabilité
• H04W 84/18 - Réseaux auto-organisés, p. ex. réseaux ad hoc ou réseaux de détection

Abrégé

The present invention relates to a method for extracting cannabinoids from cannabis plant material using an extractor with super critical carbon dioxide. The process comprises the steps of: a) providing a cannabis plant material with a water content of at most 60% w/w, preferably at most 10% w/w; b1) in a pressure tank, subjecting the cannabis plant material to a first extraction step with a one-phase solvent system comprising supercritical carbon dioxide and optionally a non-polar co-solvent, and performed at a temperature of about 30-60 degrees Celsius; c1) collecting a first liquid extract from the pressure tank; d) collecting/removing a solid product from the pressure tank comprising a cannabis plant fiber material with a reduced content of cannabinoids; e) dissolving the first liquid extract from the pressure tank in ethanol, subjecting the solution to one or more winterization steps, filtrating the solution to remove precipitated matter, and removing the ethanol to collect a second liquid extract; f) optionally, heat treating the second liquid extract at 100-150 degrees Celsius to decarboxylate any acid form of the cannabinoids to the neutral form of the cannabinoids; g) dissolving the second liquid extract, optionally heat treated, in a non-polar solvent; h) extracting the solubilized second liquid extract with an aqueous basic solution; and collecting the non-polar solvent phase as a third liquid extract; and i) optionally, removing the non-polar solvent to collect the neutral form of the cannabinoids.

Classes IPC  ?

• B01D 11/02 - Extraction par solvants de solides
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques

Abrégé

The invention relates to a method of diagnosing a migraine and/or migraine attack, the method in a subject comprising determining a change in the expression level of a biological marker in the biological sample. Preferably, the method is the in vitro method.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The invention relates to a method of determining the laxity of a joint (9, 15) of a human (5) or an animal. The method comprises providing at least one patient-specific geometrical model (1) of at least one bone and/or at least one prosthesis comprised by the joint. Known loads are applied to the joint or to a part of the body connected to the joint, and a series of actual images (16) of the joint are obtained while the loads are applied. Then the at least one patient-specific geometrical model (1) is registered onto the actual images (16). Based thereon relative displacement and/or rotation of the at least one bone and/or at least one prosthesis is calculated as a function of the applied loads, and based thereon a measure of the laxity of the joint is determined. The invention further relates to a system for performing such a method and to a computer readable medium for performing such a method.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/107 - Mesure de dimensions corporelles, p. ex. la taille du corps entier ou de parties de celui-ci
• A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales

Abrégé

A method for determining the temperature of a power semiconductor, where the power semiconductor includes an auxiliary emitter terminal and an emitter terminal, and a resistance component arranged between. The resistance component is thermally coupled and/or integrated into the semiconductor die. The resistance component is arranged between the auxiliary emitter terminal and the emitter terminal, and lies in the path of the control current. The resistance component has a temperature dependent resistance characteristic. A measurement circuit is used to inject a sufficient sensing current, or apply a suitable voltage, to the resistance component between the auxiliary emitter and emitter terminals, in order to generate an output signal that is dependent on the temperature dependent resistance of the resistance component. The output signal can be assessed with respect to a predefined temperature characteristic curve, obtained through a calibration procedure. Thus, the temperature of the semiconductor is measured.

Classes IPC  ?

• G01K 7/16 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments résistifs

Abrégé

A method is provided for determining colorectal cancer, or the prognosis of a colorectal cancer in a subject, said method comprising in a sample from said subject determining the methylation status of a specific gene marker panel.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.

Classes IPC  ?

• A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

A method for analyzing a condition of a heart, comprises receiving a plurality of electrical signals, which are acquired by non-invasive measurement on the skin of a person or animal, each signal representing electrical activity in a respective region of the heart of the person or animal; calculating a derivative value of each signal at a plurality of time instances; selecting a plurality of the calculated derivative values of a first signal and determining a first point in time of a first event based on the selected derivative values; selecting a plurality of the calculated derivative values of a second signal and determining a second point in time of a second event, corresponding to the first event, based on the selected derivative values of the second signal, and calculating at least one measure based on a difference of the first point in time and the second point in time.

Classes IPC  ?

• A61B 5/04 - Mesure de signaux bioélectriques du corps ou de parties de celui-ci
• A61N 1/362 - Stimulateurs cardiaques

Abrégé

Methods of treating Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), comprising administering an inhibitory nucleic acid that targets miR-128.

Classes IPC  ?

• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

A neurofeedback system can be used by a person for training, so as to reduce musculoskeletal pain. The system comprises a non-invasive EEG sensor to sense EEG signal from the person. A processor system, e.g. a tablet or the like, receives data values from the EEG sensor and calculates a EEG power magnitude within the EEG alpha band accordingly. The processor system is programmed to determine a baseline value indicative of EEG alpha band power, and determine, in real-time, EEG alpha band power in response to data from the EEG sensor. On a display, the processor system displays a real-time visual indication of the EEG alpha band power values compared to said baseline value. At least one attribute, e.g. color, of the visual indication is determined in response to the real-time values being above or below a threshold which is determined in response to said baseline value. In preferred embodiments, a feedback device with a sensor for sensing a start of body movement of the person provides timing feedback to the processor system to allow calculation of EEG alpha power in the preparation phase before start of the movement, and to use this as the visual EEG feedback. Specific frequency-time signatures for a specific type of pain may be used for the baseline value used in the feedback to the person during training.

Classes IPC  ?

• A61B 5/04 - Mesure de signaux bioélectriques du corps ou de parties de celui-ci
• A61B 5/048 - Détection de la répartition de fréquence dans les signaux
• A61B 5/0482 - Electro-encéphalographie utilisant une rétroaction biologique
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

Adevice and method for human intention detection (HID). In preferred embodiments, it makes use of an array of force sensing resistors (FSRs) which are embedded inside a flexible band, which is capable of reading the muscle activity for different motion type and muscle forcein a human user. In one implementation of the invention two of such bands are attached to the forearm and the upper arm. From the readings of the sensors, the patterns for motion type and muscle forceare then distinguished autonomously by machine learning, a Support Vector Machine (SVM)algorithm, or a neural network. The method is advantageous e.g. the detection of dexterous motion of the arms, upon which assistive exoskeleton can be controlled for motion assistance. The invention can also be applicable to hand gestures recognition and bilateral rehabilitation, besides this the invention can be used to control lower body exoskeleton as well.

Classes IPC  ?

• B25J 9/16 - Commandes à programme

Abrégé

A method for assessing nerve fiber excitability is disclosed. The method comprises: arranging an electrode in contact with skin of a person; determining a first and a second threshold value based on a stimulation current pulse of a first and a second waveform, respectively; wherein said determining of the first threshold value and said determining of the second threshold value each comprises: repeatedly providing a stimulation current pulse of the first or second waveform, respectively, through the electrode, wherein a stimulation current strength is altered between repetitions; and receiving signals from an interaction element with which the person interacts, said signals from the interaction element providing an indication of the first threshold value or the second threshold value, respectively, corresponding to a stimulation current strength necessary to be perceived by the person; and determining at least one measure of psychophysical perception based on the determined first and second threshold values.

Classes IPC  ?

• A61B 5/0488 - Electromyographie
• A61B 5/0484 - Electro-encéphalographie utilisant des réponses provoquées
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/04 - Électrodes
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

The present invention provides antisense oligonucleotides directed against immune checkpoints and methods and compositions of using such antisense oligonucleotides for the treatment of cancer.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

Systems and methods for estimating cardiac strain and displacement using ultrasound are disclosed. According to an aspect, a method includes receiving frames of images acquired from a subject over a period of time. The method also includes determining, in the frames of images, speckles of features of the subject. Further, the method includes tracking bulk movement of the speckles in the frame of images. The method also includes determining displacement of at least a portion of the subject based on the tracked bulk movement.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/026 - Mesure du débit sanguin
• A61B 5/0402 - Electrocardiographie, c. à d. ECG
• A61B 8/08 - Applications cliniques

Abrégé

A technology for quantifying, or determining an indication of, cardiorespiratory fitness is disclosed. A signal portion is obtained from a signal recorded with an accelerometer placed on the chest of a person. The accelerometer measures accelerations and vibrations of the chest wall of the person caused by myocardial movement. A maximum value is determined in the signal portion, and output information is provided indicating cardiorespiratory fitness based on the maximum value.

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

The present invention relates to a method and system for determining the aortic pulse wave velocity. The method comprises receiving an indication of a measurement of a length of a human aorta to provide an aortic length, arranging a first and second sound transducer outside the body of the patient, and identifying the opening of the aortic valve with measurement from the first sound transducer as a first time, and the pulse wave arrival time at the aortic bifurcation with measurements from the second sound transducer as a second time. The aortic transit time is determined based on the difference between the second time and the first time, and the aortic pulse wave velocity is calculated based on the aortic length and the aortic transit time.

Classes IPC  ?

• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
• A61B 7/04 - Stéthoscopes électriques
• A61B 5/0285 - Mesure de la vitesse de propagation de l'onde pulsatile

Abrégé

The present invention relates to noncoding RNAs as novel disease targets, and methods of modulating the activity of such ncRNA targets in patients. In particular, the invention relates to modulation of long non-coding RNAs, such as circular RNAs (circRNAs) or large intergenic noncoding RNAs (lincRNAs) in cancer using antisense oligonucleotides.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The invention relates to a spherical joint mechanism comprising two revolute joints joined by a double parallelogram linkage. The double parallelogram linkage comprises a first linkage part hingedly connected to a first revolute joint at a distal end and a second linkage part hingedly connected to a second revolute joint at a distal end. The first linkage part comprises a first link arm and a second link arm, which first and second link arms are arranged to move parallel to each other. The second linkage part comprises a third link arm and a fourth link arm, which third and fourth link arms are arranged to move parallel to each other. A proximate end of the first linkage part and a proximate end of the second linkage part are mutually hingedly connected. The invention also relates to an exoskeleton with a shoulder joint or a hip joint comprising such a spherical joint mechanism.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• A61H 3/00 - Appareils pour aider des personnes handicapées à marcher
• B25J 9/10 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs

Abrégé

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.

Classes IPC  ?

• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

There is presented a computer implemented method for calculating a probability of a clinical outcome for a patient, wherein the method comprises providing a maximum of 150 input parameters, such as a maximum of 20 input parameters, as input to a statistical model, and calculating the probability with the statistical model. The method in an embodiment further comprises performing with the statistical model an assessment of a severity of an illness of the patient, where said assessment is based partially or fully on the input parameters, and where said probability is based partially or fully on the severity of the patient's illness.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• G06N 7/00 - Agencements informatiques fondés sur des modèles mathématiques spécifiques

Abrégé

The present invention relates to an in vitro blood-brain-barrier (BBB) model comprising a porcine triple co-culture comprising porcine astrocytes, porcine primary brain endothelial cells (BEC's) and porcine pericytes. The invention also relates methods of producing such porcine triple co-cultures and uses thereof.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/079 - Cellules neurales
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention relates to an electrical machine stator comprising a plurality of stator segments (131,132,133), each segment comprises a first U-core and a second U-core wound with a winding, where the winding being arranged with at least one coil turn, each coil turn comprises a first axial coil segment and a second axial coil segment and one or more end segments, wherein the first and second axial coil segments are arranged in opposite directions to each other, and where the first U-core receives the first axial coil segment(s) and the second U-core receives the second axial coil segment(s), wherein the first U-core and the second U-core are located adjacent to each other, whereby the winding spans the first and second U-cores. The invention also relates to a SRM machine with a stator mentioned above and a rotor.

Classes IPC  ?

• H02K 1/14 - Noyaux statoriques à pôles saillants
• H02K 1/18 - Moyens de montage ou de fixation des parties magnétiques fixes sur ou aux structures constituant le stator
• H02K 1/20 - Parties fixes du circuit magnétique avec des canaux ou des conduits pour l'écoulement d'un agent de refroidissement
• H02K 1/24 - Noyaux rotoriques à pôles saillants
• H02K 5/173 - Moyens de support des paliers, p. ex. supports isolants ou moyens pour ajuster les paliers dans leurs flasques utilisant des roulements à rouleaux, p. ex. des roulements à billes
• H02K 7/08 - Association structurelle avec des paliers
• H02K 7/116 - Association structurelle avec des embrayages, des freins, des engrenages, des poulies ou des démarreurs mécaniques avec des engrenages
• H02K 19/10 - Moteurs synchrones pour courant polyphasé

Abrégé

Described are network coding (NC) systems and techniques which utilize multiple composite extension finite fields to reduce complexity at various nodes in a network and also reduce overhead due to signal coding coefficients. A coding design uses a series of finite fields where increasingly larger fields are based on a previous smaller field. Techniques disclosed herein can be applied to existing systems using Random Linear Network Coding (RLNC) or Fulcrum codes.

Classes IPC  ?

• H04L 12/861 - Mise en mémoire tampon de paquets ou mise en file d’attente; Ordonnancement de file d’attente
• H04L 1/00 - Dispositions pour détecter ou empêcher les erreurs dans l'information reçue

Abrégé

The present invention describes an inflatable cuff 1 for inducing at least compressional or shear force on a subject and evaluating pain thresholds and/or sensitivity, pain modulation, spatial and/or temporal summation of pain, or descending inhibition of pain in the subject, said cuff comprising at least two separate chambers 2, 3 of which at least one is an inflation chamber 3 and at least one is a non-inflation chamber 2, wherein the inflation chamber 3 has a coupling 4for connection to a compressor or other activator device.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The present invention relates to a set of biomarkers, which can be used to determinethe risk of developing hypoxemia for subjects undergoingopen heart surgery with the use of cardiopulmonary bypass (CPB).

Classes IPC  ?

• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet