A method for using an automated blood collection system to collect blood components from a subject includes separating plasma from whole blood as received from the subject; initiating an alert when a predicted accumulated volume loss is greater than a configured removal level, the predicted accumulated volume loss depending on an accumulated volume that includes the separated volume of plasma and the configured removal level being defined by a hypovolemic level or the pre-selected maximum for the subject; and in response to the alert and feedback from an operator of the automated blood collection system, ending the collection process, continuing the collection, or initiating platelet and red blood cell separation.
A61M 1/38 - Removing constituents from donor blood and returning remainder to body
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A method for collecting blood components includes separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from the whole blood as available after the separation of the first amount of plasma; if a total collected amount is less than a maximum as adjusted by real-time data regarding collection following the separation of the total amount of platelets, separating a second amount of plasma from the whole blood as available after the separation of the total amount of platelets and then separating a total amount of red blood cells from the whole blood as available after the separation of the second amount of plasma; and if the total collected amount is at the maximum as adjusted by real-time data regarding collection, separating the total amount of red blood cells from the whole blood as available after the separation of the total amount of platelets.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and installable medical software for formatting
and transferring data from a medical device to an on-site
information database; downloadable and installable computer
software for transferring data from a medical device to an
on-site information database; downloadable and installable
communication software to access a medical device stored on
a blood or blood component device and transfer data to
another device; downloadable and installable medical device
software for transfer of data; downloadable and installable
computer software for management of device run data;
downloadable and installable computer software for use in
formatting and transferring device run data; downloadable
and installable computer software for use in the field of
medical device data management; downloadable and installable
computer software specialized for use in data management to
enterprises worldwide in the medical industry; downloadable
and installable computer software for connecting multiple
devices or information databases, bidirectional
communication with information management systems and
devices, storing and managing electronic data. Computer services, specifically involving the formatting and
transfer of run data from automated blood collection systems
to an information database.
4.
Apparatuses, Systems, and Methods for Plasma Rinseback
A system for minimizing a residual blood value via a plasma rinseback includes a collection bag, a return reservoir, one or more pumps, and one or more lines. The collection bag is configured to store plasma collected from a donor during a donation process. The return reservoir is configured to collect fluid remaining in the system after the donation process is complete. The one or more pumps are configured to be actuated between an operational state and a nonoperational state during the donation process and the plasma rinseback. The one or more lines are configured to couple the collection bag, the return reservoir, the one or more pumps, and the donor. The system is configured to complete the plasma rinseback to return fluid within the system to the donor after the donation process is complete.
A system for minimizing a residual blood value via a plasma rinseback includes a collection bag, a return reservoir, one or more pumps, and one or more lines. The collection bag is configured to store plasma collected from a donor during a donation process. The return reservoir is configured to collect fluid remaining in the system after the donation process is complete. The one or more pumps are configured to be actuated between an operational state and a nonoperational state during the donation process and the plasma rinseback. The one or more lines are configured to couple the collection bag, the return reservoir, the one or more pumps, and the donor. The system is configured to complete the plasma rinseback to return fluid within the system to the donor after the donation process is complete.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
45 - Legal and security services; personal services for individuals.
Goods & Services
Business management consulting and advisory services for the medical device industry Training in the use and operation of medical devices and consultation relating thereto; Educational services, namely, providing classes, seminars, conferences, and workshops in the field of surgery, medicine and healthcare, and the distribution of course materials in connection therewith. Medical research; Providing technological and scientific information about medical devices, biotechnology devices and software development; computer programming and computer consulting services in the blood product collection and plasma-derived product manufacturing industries Technical consulting services in the field of health care and medicine Regulatory compliance consulting in the field of medical devices
A method for producing T-cells using a cell expansion system includes expanding T-cells using a small bioreactor of the cell expansion system, the small bioreactor having a surface area of about 2,000 cm2 and an intracapillary volume of about 58 milliliters. The method further includes causing T-cells to flow into a small bioreactor of the cell expansion system. A rate at which the T-cells flow into the small bioreactor may be greater than or equal to about 0.007 μL/min/fiber to less than or equal to about 0.0281 μL/min/fiber. The cell expansion system may further include a tubing set that is in fluid communication with the small bioreactor and a volume ratio of the tubing set to the bioreactor may be about 2.96.
A method for producing T-cells using a cell expansion system includes expanding T-cells using a small bioreactor of the cell expansion system, the small bioreactor having a surface area of about 2,000 cm2 and an intracapillary volume of about 58 milliliters. The method further includes causing T-cells to flow into a small bioreactor of the cell expansion system. A rate at which the T-cells flow into the small bioreactor may be greater than or equal to about 0.007 μL/min/fiber to less than or equal to about 0.0281 μL/min/fiber. The cell expansion system may further include a tubing set that is in fluid communication with the small bioreactor and a volume ratio of the tubing set to the bioreactor may be about 2.96.
A lyophilization container includes a first section having a first layer, a second layer aligned with the first layer, and a cavity defined by the alignment of the first and second layers, where at least one of the first and second layers is preformed to have a three-dimensional shape. A lyophilization fixture includes a base member and a lid member. The lid member is movable between a first position and a second position relative to the base member. The base member and lid member together define a housing that receives at least a portion of a lyophilization container.
B65D 75/24 - Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding the sheet or blank being recessed to accommodate contents and formed with several recesses to accommodate a series of articles or quantities of material
B29C 51/10 - Forming by pressure difference, e.g. vacuum
B65D 65/38 - Packaging materials of special type or form
B65D 75/52 - Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers - Details
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
10.
Methods To Remove Solutes Without Suspension Cell Loss
A method for removing solutes while retaining suspension cells within a bioreactor includes positioning a suspension including cells within a predetermined region of the bioreactor and causing a flow rate across the suspension in the bioreactor, where the flow rate is selected to cause the solutes to move out of the bioreactor while the cells are maintained in the bioreactor.
A method for removing solutes while retaining suspension cells within a bioreactor includes positioning a suspension including cells within a predetermined region of the bioreactor and causing a flow rate across the suspension in the bioreactor, where the flow rate is selected to cause the solutes to move out of the bioreactor while the cells are maintained in the bioreactor.
A method for collection blood component using a medical system includes receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including a subject's initial hematocrit; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system determined using the subject hematocrit, a total blood volume for the subject, and a targeted change in hematocrit; and performing, using the medical system, a component donation process to collect the identified subject-specific pure component amount to be collected.
A method for collection blood component using a medical system includes receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including a subject's initial hematocrit; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system determined using the subject hematocrit, a total blood volume for the subject, and a targeted change in hematocrit; and performing, using the medical system, a component donation process to collect the identified subject-specific pure component amount to be collected.
A tube clamp arrangement includes a first mounting plate and a second mounting plate. The first mounting plate is configured to join together a first tube-holding assembly and a first adjustment mechanism, where the first adjustment mechanism is configured to move in a first direction in a first plane. The second mounting plate is configured to join together a second tube-holding assembly and a second adjustment mechanism, where the second adjustment mechanism is configured to move in a second direction in the first plane.
B23K 37/04 - Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the other main groups of this subclass for holding or positioning work
An assembly for testing a quality of a weld joining a first section of tubing to a second section of the tubing includes a track, a first tubing engagement structure coupled to the track and translatable along the track, a second tubing engagement structure connected to the track, an actuator, and a load cell. The actuator is operable to translate the first tubing engagement structure along the track in a first direction toward the second tubing engagement structure and in a second direction away from the second tubing engagement structure. The load cell is operable to measure at least one of a compression load and a tensile load applied to the tubing by the first and second tubing engagement structures.
G01N 3/10 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
B23K 31/02 - Processes relevant to this subclass, specially adapted for particular articles or purposes, but not covered by any single one of main groups relating to soldering or welding
G01M 3/28 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for valves
A tube clamp arrangement includes a first mounting plate and a second mounting plate. The first mounting plate is configured to join together a first tube-holding assembly and a first adjustment mechanism, where the first adjustment mechanism is configured to move in a first direction in a first plane. The second mounting plate is configured to join together a second tube-holding assembly and a second adjustment mechanism, where the second adjustment mechanism is configured to move in a second direction in the first plane.
B23K 37/047 - Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the other main groups of this subclass for holding or positioning work moving work to adjust its position between soldering, welding or cutting steps
B23K 37/053 - Auxiliary devices or processes, not specially adapted to a procedure covered by only one of the other main groups of this subclass for holding or positioning work aligning cylindrical work; Clamping devices therefor
B29C 65/78 - Means for handling the parts to be joined, e.g. for making containers or hollow articles
An assembly for testing a quality of a weld joining a first section of tubing to a second section of the tubing includes a track, a first tubing engagement structure coupled to the track and translatable along the track, a second tubing engagement structure connected to the track, an actuator, and a load cell. The actuator is operable to translate the first tubing engagement structure along the track in a first direction toward the second tubing engagement structure and in a second direction away from the second tubing engagement structure. The load cell is operable to measure at least one of a compression load and a tensile load applied to the tubing by the first and second tubing engagement structures.
A tube-joining device for joining two flexible tube sections including a tube holder configured to hold the flexible tube sections in place for joining. The tube holder may have a clamped and a non-clamped configuration. The tube holder may have a start and a finish configuration. The tube holder may have tube detectors. When certain criteria are met, the tube holder may automatically begin a tube-joining operation, or may automatically return itself from the finish to the start configuration, or the tube-joining device may automatically begin heating a blade used for cutting and melting the tubes.
A tube opening device may include a mounting base defining a tube-receiving cavity, a first tube-engaging surface extending into the tube-receiving cavity, a first linear-motion actuator secured to the mounting base and configured to move the first tube-engaging surface between the first retracted position and a first extended position, a second tube-engaging surface extending into the tube-receiving cavity, a second linear-motion actuator secured to the mounting base and configured to move the second tube-engaging surface between the second retracted position and a second extended position, a third tube-engaging surface extending into the tube-receiving cavity, and a third linear-motion actuator secured to the mounting base and configured to move the third tube-engaging surface between the third retracted position and a third extended position.
A method of initiating a tube joining process includes receiving, with a tube joining device, data associated with a cartridge. The method further includes determining whether the cartridge is authentic based on the data. The method further includes, in response to a determination that the cartridge is authentic, initiating the tube joining process. A method of verifying media combination protocol includes verifying a first media bag. The verifying includes receiving, with a tube joining device, first data associated with the first media bag. The receiving includes concurrently scanning, with a scanner, a first plurality of items. The method further includes mapping the first plurality of items to a first plurality of predetermined fields. The method further includes, after the mapping, determining whether a first predetermined condition is met.
G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
24.
Tube Joining Device With Modular Accessories And Protocol Assurance
A tube joining device includes a housing, a first subassembly, and a second subassembly. The housing defines an interior region. The housing includes a first contact. The first contact is electrically conductive. The first subassembly includes a tube joining subassembly. The tube joining subassembly is at least partially in the interior region. The second subassembly is configured to be coupled to the housing. The second subassembly includes a second contact. The second contact is electrically conductive. The second subassembly is configured to be coupled to the housing by an elongated dovetail joint. The first contact is configured to be in electrical communication with the second contact to form a connection including a ground connection, a data connection, a power connection, or any combination thereof.
A tube-joining device for joining two flexible tube sections including a tube holder configured to hold the flexible tube sections in place for joining. The tube holder may have a clamped and a non-clamped configuration. The tube holder may have a start and a finish configuration. The tube holder may have tube detectors. When certain criteria are met, the tube holder may automatically begin a tube-joining operation, or may automatically return itself from the finish to the start configuration, or the tube-joining device may automatically begin heating a blade used for cutting and melting the tubes.
A tube opening device may include a mounting base defining a tube-receiving cavity, a first tube-engaging surface extending into the tube-receiving cavity, a first linear-motion actuator secured to the mounting base and configured to move the first tube-engaging surface between the first retracted position and a first extended position, a second tube-engaging surface extending into the tube-receiving cavity, a second linear-motion actuator secured to the mounting base and configured to move the second tube-engaging surface between the second retracted position and a second extended position, a third tube-engaging surface extending into the tube-receiving cavity, and a third linear-motion actuator secured to the mounting base and configured to move the third tube-engaging surface between the third retracted position and a third extended position.
A tube joining device includes a housing, a first subassembly, and a second subassembly. The housing defines an interior region. The housing includes a first contact. The first contact is electrically conductive. The first subassembly includes a tube joining subassembly. The tube joining subassembly is at least partially in the interior region. The second subassembly is configured to be coupled to the housing. The second subassembly includes a second contact. The second contact is electrically conductive. The second subassembly is configured to be coupled to the housing by an elongated dovetail joint. The first contact is configured to be in electrical communication with the second contact to form a connection including a ground connection, a data connection, a power connection, or any combination thereof.
A61M 39/14 - Tube connectors or tube couplings for connecting tubes having sealed ends
A61M 39/18 - Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
H01R 13/22 - Contacts for co-operating by abutting
H01R 13/28 - Contacts for sliding co-operation with identically-shaped contact, e.g. for hermaphroditic coupling devices
H01R 13/514 - Bases; Cases formed as a modular block or assembly, i.e. composed of co-operating parts provided with contact members or holding contact members between them
A method of initiating a tube joining process includes receiving, with a tube joining device, data associated with a cartridge. The method further includes determining whether the cartridge is authentic based on the data. The method further includes, in response to a determination that the cartridge is authentic, initiating the tube joining process. A method of verifying media combination protocol includes verifying a first media bag. The verifying includes receiving, with a tube joining device, first data associated with the first media bag. The receiving includes concurrently scanning, with a scanner, a first plurality of items. The method further includes mapping the first plurality of items to a first plurality of predetermined fields. The method further includes, after the mapping, determining whether a first predetermined condition is met.
A tube welding device for joining tubes includes a first tube-holding assembly configured to receive a first portion of a first tube and a first portion of a second tube, and a second tube-holding assembly configured to receive a second portion of the first tube and a second portion of the second tube. The first tube-holding assembly includes a first detector, and the second tube-holding assembly includes a second detector. The first and second detectors are configured to detect the presence or absence of fluid in the respective tubes and to generate signals indicative of the same. The tube welding device includes a controller configured to receive the signals, to select an appropriate tube-joining temperature in response to the presence or absence of fluid in the first and second tubes, and to cause an appropriate power level to be sent to a wafer to generate the tube-joining temperature.
A tube opening device includes a body having a first side and a second side and including a tube-receiving cavity. The first side of the body includes a first belt system disposed on a first side of the tube-receiving cavity and a second belt system disposed on a second side of the tube-receiving cavity. The first and second belt systems are configured to apply pressure to a tube received in the tube-receiving cavity to open temporary seals and form a continuous tube.
A tube welding device for joining tubes includes a first tube-holding assembly configured to receive a first portion of a first tube and a first portion of a second tube, and a second tube-holding assembly configured to receive a second portion of the first tube and a second portion of the second tube. The first tube-holding assembly includes a first detector, and the second tube-holding assembly includes a second detector. The first and second detectors are configured to detect the presence or absence of fluid in the respective tubes and to generate signals indicative of the same. The tube welding device includes a controller configured to receive the signals, to select an appropriate tube-joining temperature in response to the presence or absence of fluid in the first and second tubes, and to cause an appropriate power level to be sent to a wafer to generate the tube-joining temperature.
B29C 65/20 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure using heated tool with direct contact, e.g. using "mirror"
A tube opening device includes a body having a first side and a second side and including a tube-receiving cavity. The first side of the body includes a first belt system disposed on a first side of the tube-receiving cavity and a second belt system disposed on a second side of the tube-receiving cavity. The first and second belt systems are configured to apply pressure to a tube received in the tube-receiving cavity to open temporary seals and form a continuous tube.
A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.
G16H 40/00 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
36.
BLOOD COMPONENT COLLECTION SET WITH INTEGRATED SAFETY FEATURES
A separation assembly for an apheresis system includes a first media bag, a second media mag, a vessel, and a separation set. The first media bag contains a first fluid medium. The second media bag contains a second fluid medium. The vessel is configured to contain a third fluid medium. The separation set includes a first tube and a second tube. The first tube has a first fitting that is configured to be coupled to the first media bag. The first tube defines a first length. The second tube has a second fitting that is configured to be coupled to the second media bag. The second tube defines a second length different from the first length. The separation set may further includes a third tube is configured to be coupled to the vessel.
A method includes detecting a startup of an apheresis machine; in response to detecting start up, transmitting data to a server; determining, based on the data, whether software of the apheresis machine is current; receiving, in response to the data, a response from the server; and preventing usage of apheresis machine if the response indicates the software is not current. The data transmitted to the server may include one or more of a data log, a firmware version identifier, and an error log. The response may include a lockout signal. The response may include a software update. The software update may include a firmware update. The method may include automatically initiating installation of the software update. The method may include ceasing prevention of usage of the apheresis machine following installation of the software update.
G06F 21/51 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems at application loading time, e.g. accepting, rejecting, starting or inhibiting executable software based on integrity or source reliability
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
A method includes initiating one or more pumps of an apheresis machine, detecting a flow of fluid through the apheresis machine, detecting the flow of fluid is below a predetermined threshold, and in response to detecting the flow of fluid is below the predetermined threshold, adjusting a rate of the one or more pumps of the apheresis machine.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Downloadable, cloud-based, and recorded computer software for use in control and operation of medical devices; Downloadable, cloud-based, and recorded computer software for use in operation of blood and blood plasma processing equipment; Computer software for controlling an automated blood collection and separation system.
40.
CELL EXPANSION SYSTEMS INCLUDING BIOMASS CAPACITANCE SENSORS AND METHODS OF INTEGRATING AND USING THE SAME
A cell expansion system includes a bioreactor including a first fluid circulation path and a second fluid circulation path, a control system configured to manage one or more first parameters in the first fluid circulation path and one or more second parameters in the second fluid circulation path, and one or more sensors configured to measure at least one of cell capacitance and cell impedance within the bioreactor and to communicate with the control system in communication with at least one of the first fluid circulation path and the second fluid circulation path.
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
41.
Systems And Methods For Using Microfluidic Devices With Apheresis Systems
The present disclosure provides a system for using an in-line processing device with an apheresis device. The system includes a pressure system that includes a container configured to receive cells collected using the apheresis device and is configured to change a pressure of the container so as to direct the cells collected using the apheresis device to the in-line processing device.
A cell culturing system includes a cell culturing device and a support device. The cell culturing device cultures cells by allowing a culture medium inside circulation flow paths connected to the bioreactor to flow inside the bioreactor. The cell culturing device is connected to the circulation flow paths and includes a waste liquid flow path in order to discard the liquid flowing through the circulation flow paths, and a waste liquid accommodation unit in which the liquid guided from the waste liquid flow path is accommodated. A sampling unit, in which the culture medium that is guided from the circulation flow paths to the waste liquid flow path is collected, is connected to the waste liquid flow path.
A cell culturing system is equipped with a cell culturing device and a support device. The cell culturing device comprises a culturing unit and a sampling unit. The support device includes a housing and a sampling support unit. The housing includes an accommodation chamber in which the culturing unit is accommodated. A sampling circuit unit is capable of being attached to and detached from the sampling support unit. The sampling support unit is installed on the outer surface of the housing.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable, installable or cloud-based mobile and computer
software platforms for medical devices; Downloadable,
installable or cloud-based mobile and computer software for
use in the field of medical device enterprise information
management; Downloadable, installable or cloud-based mobile
and computer software specialized for use in process
control, business operations, data management and supply
chain solutions to enterprises worldwide in the medical
industry; Downloadable, installable and cloud based mobile
and computer software for consistent process control,
comprehensive data management, analytics and complete
operational visibility and control; Downloadable,
installable or cloud-based mobile and computer software for
connecting multiple devices, bidirectional communication
with information management systems and devices, customized
process control, electronic data capture, central device
management, storing and managing electronic data and
monitoring. Platform as a service (paas) featuring mobile and computer
software platforms for enterprise asset management for
medical devices; platform as a service (paas) featuring
mobile and computer software platforms for use in database
management, process control and operational visibility;
consulting services in the field of cloud computing
technology, infrastructure-as-a-service (iaas) cloud
computing technology, software-as-a-service (saas) cloud
computing technology, and platform-as-a-service (paas) cloud
computing technology; platform as a service (paas) featuring
mobile and computer software platforms for enabling
customers to plan, personalize, optimize, monitor, analyze
and measure operational efficiency; Software as a service
(SAAS) services, namely, hosting software for use by others
for centralized device management, create custom workflow,
device monitoring, bidirectional communication with devices
and information systems and data management and analytics;
Software as a service (SAAS) services featuring software for
customized and consistent process control, electronic data
capture, storing and managing electronic data and
operational visibility.
A lyophilizer includes a shelf and a container, at least one of the shelf and the container including a material having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0. A shelf plate includes a plate body and a material layer disposed on or defining one or more surfaces of the plate body, the material layer having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
F26B 25/00 - DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM - Details of general application not covered by group or
A lyophilizer includes a shelf and a container, at least one of the shelf and the container including a material having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0. A shelf plate includes a plate body and a material layer disposed on or defining one or more surfaces of the plate body, the material layer having an emissivity greater than or equal to about 0.6 to less than or equal to about 1.0.
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
F26B 15/04 - Machines or apparatus for drying objects with progressive movement; Machines or apparatus with progressive movement for drying batches of material in compact form with movement in the whole or part of a circle in a horizontal plane
09 - Scientific and electric apparatus and instruments
Goods & Services
Downloadable software, downloadable cloud-based software, and recorded computer software for use in control and operation of medical devices; Downloadable software, downloadable cloud-based software, and recorded computer software for use in operation of blood and blood plasma processing equipment; Downloadable software, downloadable cloud-based software, and recorded computer software for controlling an automated blood collection and separation system
50.
Methods And Systems For High-Throughput Blood Component Collection
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
In a fusion bonding wafer (18), a tube fusion bonding device (10), and a tube fusion bonding method, the fusion bonding wafer (18) is equipped with first and second substrates formed in a flat plate shape, a heating element formed between the inner surfaces of the first and second substrates, and a temperature measurement hole (44) that penetrates through the second substrate in a thickness direction thereof and exposes the inner surface of the first substrate. The temperature measurement hole allow temperature in the interior of the fusion bonding wafer (18) to be detected. Ideally, a non-contact sensor, e.g. infrared radiation thermometer (70), detects the temperature of the wafer (18). Advantageously, the wafer is used to cut and weld resin tubes such as those for medical use.
B29C 65/20 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure using heated tool with direct contact, e.g. using "mirror"
B29C 65/78 - Means for handling the parts to be joined, e.g. for making containers or hollow articles
H05B 3/26 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor mounted on insulating base
A61M 39/14 - Tube connectors or tube couplings for connecting tubes having sealed ends
Cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. The cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
Cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. The cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
C12M 3/02 - Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells
A disposable bag set for separating discrete volumes of a composite fluid includes a separation bag including the composite fluid to be separated; a first bag in fluid communication with the separation bag, the first bag configured to receive a first component of the composite fluid from the separation bag; and a second bag in fluid communication with the first bag and not the separation bag, the second bag configured to receive a product formed using the first component.
A disposable bag set for separating discrete volumes of a composite fluid includes a separation bag including the composite fluid to be separated; a first bag in fluid communication with the separation bag, the first bag configured to receive a first component of the composite fluid from the separation bag; and a second bag in fluid communication with the first bag and not the separation bag, the second bag configured to receive a product formed using the first component.
41 - Education, entertainment, sporting and cultural services
45 - Legal and security services; personal services for individuals.
Goods & Services
Business management consulting and advisory services for the
medical device industry. Training in the use and operation of medical devices and
consultation relating thereto. Regulatory compliance consulting in the field of medical
devices.
58.
METHODS FOR CELL EXPANSION, DIFFERENTIATION, AND/OR HARVESTING OF NATURAL KILLER CELLS USING HOLLOW-FIBER MEMBRANES
A method for functionalizing a hollow-fiber membrane for cell expansion of targeted cells (e.g., natural killer cells) includes contacting a biotinylating molecule to a surface of the hollow-fiber membrane including an extracellular matrix component, the biotinylating molecule binding to the extracellular matrix component and having an affinity for the targeted cells. The biotinylated molecule may be selected from the group consisting of: cytokine, epitope, ligand, monoclonal antibody, stains, aptamer, and combinations thereof. The extracellular matrix component may be selected from the group consisting of: fibronectin, vitronectin, fibrinogen, collagen, laminin, and combinations thereof.
A method for functionalizing a hollow-fiber membrane for cell expansion of targeted cells (e.g., natural killer cells) includes contacting a biotinylating molecule to a surface of the hollow-fiber membrane including an extracellular matrix component, the biotinylating molecule binding to the extracellular matrix component and having an affinity for the targeted cells. The biotinylated molecule may be selected from the group consisting of: cytokine, epitope, ligand, monoclonal antibody, stains, aptamer, and combinations thereof. The extracellular matrix component may be selected from the group consisting of: fibronectin, vitronectin, fibrinogen, collagen, laminin, and combinations thereof.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Transfer of run data information from automated blood collection systems and providing to an information database by telecommunication and internet Downloadable medical software for formatting and transferring data from a medical device to an on-site information database; Downloadable computer software for transferring data from a medical device to an on-site information database; Downloadable communication software to access a medical device stored on a blood or blood component device and transfer data to another device; Downloadable medical device software for transfer of data; Downloadable computer software for management of device run data; Downloadable computer software for use in formatting and transferring device run data; Downloadable computer software for use in accessing, formatting, transferring, and managing data in the field of medical device data management; Downloadable computer software specialized for use in data management to enterprises worldwide in the medical industry; Downloadable computer software for connecting multiple devices or information databases, bidirectional communication with information management systems and devices, storing and managing electronic data Computer services, namely, formatting run data information for others generated by automated blood collection systems for others
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
A controller 44 fixes an antibody 30 or an aptamer to a surface 26 of a base material 20 of a filter 10 by operating a pump 78 in a state where first valves (76c, 76d) are open and a second valve (76a) is closed and passing a first liquid through the base material 20, and captures an isolation target by the antibody 30 or the aptamer by, after the antibody 30 or the aptamer is fixed on the surface 26 of the base material 20, operating the pump 78 in a state where the first valves are closed and the second valve is open and passing a second liquid through the base material 20.
Methods and devices for separating components from multi-component fluids are provided. A method for collecting a blood component includes drawing whole blood into a centrifuge, spinning the centrifuge to cause centrifugal force to act on the whole blood to separate the whole blood into a least a first blood component and a second blood component that is different from the first blood component, extracting the first blood component from the centrifuge, detecting when the second blood component is about to be extracted from the centrifuge, and after the second blood component is detected and while the centrifuge continues to spin, flowing the separated first blood component back towards the centrifuge to move at least the second blood component from the centrifuge.
[Solution] A filter 10 comprises: a base material 20 that is composed of porous polyurethane, in which a plurality of fine pores are formed; and an active group 28 that is fixed to a surface 26 of the base material 20 and is capable of forming a specific bond with an object to be separated.
Methods and devices for separating components from multi-component fluids are provided. A method for collecting a blood component includes drawing whole blood into a centrifuge, spinning the centrifuge to cause centrifugal force to act on the whole blood to separate the whole blood into a least a first blood component and a second blood component that is different from the first blood component, extracting the first blood component from the centrifuge, detecting when the second blood component is about to be extracted from the centrifuge, and after the second blood component is detected and while the centrifuge continues to spin, flowing the separated first blood component back towards the centrifuge to move at least the second blood component from the centrifuge.
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
A cell culturing system includes a processing unit that cultures cells, a reactor installation device in which the processing unit is installable, a connection circuit connected to the processing unit, a circuit control device to and from which the connection circuit is attachable and detachable, and a tank device including a culture medium accommodation unit for accommodating the culture medium. The processing unit includes a plurality of bioreactors. The culture medium in the culture medium accommodation unit is supplied to the processing unit via the connection circuit. The culture medium accommodation unit is capable of accommodating the culture medium of an amount required for culturing the cells in the processing unit.
A cell culturing system includes a reactor, a flow channel that allows a culture medium to flow into and out of the reactor, a waste liquid channel that discharges the culture medium from the flow channel, and a waste liquid container capable of storing the culture medium passing through the waste liquid channel. The waste liquid channel includes a temporary storage unit capable of temporarily storing the culture medium. The waste liquid container is located below the temporary storage unit) in a gravity direction, and the temporary storage unit is provided above the flow channel in the gravity direction. The temporary storage unit temporarily stores the culture medium discharged from the flow channel and allows the culture medium to flow out toward the waste liquid container.
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
A cell culturing system includes a processing unit that performs culturing of cells, a reactor installation device in which the processing unit is capable of being installed, a connection circuit that is connected to the processing unit, and a circuit control device to which the connection circuit is capable of being attached to and detached from and that is capable of supplying the cells and a culture medium from the connection circuit to the processing unit, and to receive a collection of cultured cells from the processing unit into the connection circuit. The processing unit includes a plurality of bioreactors. The reactor installation device is disposed separately with respect to the circuit control device.
An apheresis system includes a chamber configured to receive a centrifuge assembly and a moving loop holder. The moving loop holder includes a loop holder that has a loop connection that is configured to interact with a flexible loop received by the centrifuge assembly. The moving loop holder is configured to move between a first position and a second position, where in the first position, the moving loop holder is a first distance from the centrifuge assembly, and in the second position, the moving loop holder is a second distance from the centrifuge assembly. The centrifuge assembly is prevented from moving from an operating state to a loading state when the moving loop holder is in the first position, and the centrifuge assembly is allowed to move from the operating state to the loading state when the moving loop holder is in the second position.
A cell culturing system is equipped with a plurality of processing units that perform culturing of cells, a plurality of reactor installation devices in which the plurality of processing units are capable of being respectively installed, a plurality of connection circuits connected respectively to the plurality of processing units, a plurality of circuit control devices which the plurality of connection circuits are capable of being respectively attached to and detached from, and a sensor device. The sensor device is used in common with respect to the plurality of processing units in order to measure components of the culture medium guided into the plurality of processing units. Each of the plurality of processing units includes a plurality of bioreactors.
A method includes initiating one or more pumps of an apheresis machine, detecting a flow of fluid through the apheresis machine, detecting the flow of fluid is below a predetermined threshold, and in response to detecting the flow of fluid is below the predetermined threshold, adjusting a rate of the one or more pumps of the apheresis machine.
A collection bottle includes a lid and a canister. The canister has a closed end and an opened end and defines an interior space. The lid includes a lid body having a first side and a second side, a shield handle, and one or more ports. The first side of the lid body is configured to be coupled to the open end of the body to close the interior space. The shield handle and the one or more ports extend from the second side of the lid body. The shield handle extends a first distance from the second side of the lid body. The one or more ports extend a second distance from the second side of the lid body. The first distance is greater than the first distance.
A flexure-based tubing state sensor includes a flexure block and a pressure sensor. The flexure block includes a body with a sensor aperture, a lever arm configured to pivot about a pivot axis between an unpivoted state and a pivoted state and including a tubing contact section and a sensor contact section arranged a first distance from the sensor aperture in the unpivoted state and a second distance from the sensor aperture in the pivoted state, a first flexure, a second flexure, and a fixed wall section disposed offset a tubing gap distance from the tubing contact section of the lever arm. The pressure sensor includes a pressure region adjacent the sensor aperture and in contact with the sensor contact section. The pressure sensor may detect pressure at the tubing contact section via rotation of the lever arm and the sensor contact section acting on the pressure region.
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
79.
Bottle Tray With Magnetic Coupling And Load Cell Overload Protection
A load cell assembly includes a load cell and a deflection portion. The load cell includes a fixed end and a free end. The free end is configured to receive a force in a first direction. The deflection portion includes a first component and a second component. The first component is coupled to the free end of the load cell. The first component defines a first cam surface. The second component is configured to support the vessel. The second component defines a second cam surface. The second cam surface is configured to engage the first cam surface. In an engaged state, the second cam surface is in continuous direct contact with the first cam surface. In a disengaged state, at least a portion of the second cam surface is disengaged from the first cam surface. The load cell assembly includes a central axis.
A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
81.
AUTOMATIC OPERATIONAL CONTROL BASED ON DETECTED ENVIRONMENTAL STATE
A method includes detecting a condition including one or more of a change in flow of a fluid and a change in a composition of the fluid, issuing an alarm in response to the condition detected, lowering a flow rate; and attempting to restart process and increase the flow rate. The change in flow may include a change in pressure. The change in flow may be associated with a collapsed vein. The change in flow of the fluid may include detecting that the flow rate has fallen below a threshold. The change in the composition may be associated with a color. The change in the composition may include using a color sensor to detect one or more of a red, a green, and a blue reflection or transmission to detect red blood cells.
An apheresis system may include an assembly for separating a component from a multi-component fluid, a processor, and a memory storing data for processing by the processor. The data, when processed, may cause the processor to run a calibration test on one or more instruments of the assembly and, based the one or more instruments failing the calibration test, calibrate the one or more instruments or lock the apheresis system for non-use. The apheresis system may include a pump configured to generate a calibration pressure at a test port and a pressure sensor configured to sense a pressure at the test port. The calibration test may include comparing the calibration pressure at the test port to the sensed pressure by the pressure sensor at the test port.
A reusable package is capable of being arranged in an expanded or device transport, state and a compact, or storage, state. In the compact state, the reusable package takes up less than half of the volume or space of the reusable package in the expanded state. The reusable package includes a base, a lid, and a sidewall support structure that is disposed between the base and the lid. The sidewall support structure has four sidewalls joined together in a rectangular shape. At least two of the sidewalls may have creases arranged along a height of the sidewalls. The sidewall support structure is collapsible at the creases when moved into the compact state.
A collection bottle includes a lid and a canister. The canister has a closed end and an opened end and defines an interior space. The lid includes a lid body having a first side and a second side, a shield handle, and one or more ports. The first side of the lid body is configured to be coupled to the open end of the body to close the interior space. The shield handle and the one or more ports extend from the second side of the lid body. The shield handle extends a first distance from the second side of the lid body. The one or more ports extend a second distance from the second side of the lid body. The first distance is greater than the first distance.
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.
An apheresis system includes a chamber configured to receive a centrifuge assembly and a moving loop holder. The moving loop holder includes a loop holder that has a loop connection that is configured to interact with a flexible loop received by the centrifuge assembly. The moving loop holder is configured to move between a first position and a second position, where in the first position, the moving loop holder is a first distance from the centrifuge assembly, and in the second position, the moving loop holder is a second distance from the centrifuge assembly. The centrifuge assembly is prevented from moving from an operating state to a loading state when the moving loop holder is in the first position, and the centrifuge assembly is allowed to move from the operating state to the loading state when the moving loop holder is in the second position.
A fluid collection loop includes a flexible tube having a first end and a second end, a connector, and a fluid component collection bladder. The connector is configured to couple the first end of the flexible loop and the fluid component collection bladder. The fluid component collection bladder includes a first chamber defined between a top end and a flow chamber separator, and a second chamber defined between a bottom end and the flow chamber separator. The flow chamber separator extends from a first end of the fluid component collection bladder towards a second end of the fluid component collection bladder and a gap exists between the fluid component collection bladder and the second end of the fluid component collection bladder.
A method includes detecting a startup of an apheresis machine; in response to detecting start up, transmitting data to a server; determining, based on the data, whether software of the apheresis machine is current; receiving, in response to the data, a response from the server; and preventing usage of apheresis machine if the response indicates the software is not current. The data transmitted to the server may include one or more of a data log, a firmware version identifier, and an error log. The response may include a lockout signal. The response may include a software update. The software update may include a firmware update. The method may include automatically initiating installation of the software update. The method may include ceasing prevention of usage of the apheresis machine following installation of the software update.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
An apheresis system at least partially defines a chamber and includes centrifuge that is movable between lock and unlock states. The centrifuge includes a base, cover, lock assembly, and latch assembly. The cover engages the base and defines slots. The lock assembly is coupled to the base and rotates between latched and unlatched states. The lock assembly includes tabs and a protrusion. The tabs are in the slots of the cover. The protrusion at least partially defines a receptacle. The latch assembly is coupled to the base and includes a lever and engagement component attached thereto. In the latched state, the protrusion engages the engagement component to reduce or prevent rotation of the lock assembly. In the unlatched state, the lock assembly can rotate. In the lock state, the tabs are at least partially within the slots. In the unlock state, the cover is movable with respect to the base.
A modular serviceability sled includes a frame, subassembly, interconnection, gasket, and shielding component. The interconnection is operatively connected to the subassembly and includes an electrical, pneumatic, and/or hydraulic connection. The gasket can engage the frame and a base assembly of an apparatus. The shielding component can contact the frame and the base assembly and includes an electromagnetic interference and/or radio frequency shielding component. The sled is movable between an engaged state and a disengaged state. In the engaged state, the sled is at least partially within a receiving space of the apparatus, the gasket engages the frame and the base assembly, the shielding component contacts the frame and the base assembly, and the interconnection is operatively connected to a machine interconnection of the apparatus. In the disengaged state, the interconnection is disconnected from the machine interconnection and the sled is configured to freely move with respect to the base assembly.
A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.
A separation assembly for an apheresis system includes a first media bag, a second media mag, a vessel, and a separation set. The first media bag contains a first fluid medium. The second media bag contains a second fluid medium. The vessel is configured to contain a third fluid medium. The separation set includes a first tube and a second tube. The first tube has a first fitting that is configured to be coupled to the first media bag. The first tube defines a first length. The second tube has a second fitting that is configured to be coupled to the second media bag. The second tube defines a second length different from the first length. The separation set may further includes a third tube is configured to be coupled to the vessel.
A method includes receiving, with an apheresis system, data associated with a donor; determining, based on the data associated with a donor, an identification of the donor; receiving, with the apheresis system, data associated with a blood component collection set; receiving, with the apheresis system, data associated with a plasma collection bottle; and performing, with the apheresis system, a plasma donation process based on the identification of the donor, the data associated with the blood component set, and the data associated with the plasma collection bottle. Receiving the data associated with the donor may include scanning, with a scanner, an image. The scanner is disposed on the apheresis system and the image may include one of a one-dimensional barcode or a two-dimensional barcode. The data associated with the donor may be displayed on a user device.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
94.
FLUID CONTROL AND BYPASS FEATURES FOR AN APHERESIS SYSTEM
A pump for fluids includes a rotor sub-assembly, a tubing pressure block, an inlet guide, an outlet guide, and a tubing guard. The rotor sub-assembly includes at least one roller. The tubing pressure block includes a raceway and at least one projection. The tubing pressure block is movable between a first position and a second position. The inlet guide includes an inlet tubing channel and is disposed proximate to a first side of the tubing pressure block. The outlet guide includes an outlet tubing channel and is disposed proximate to a second side of the tubing pressure block. The tubing guard is configured to engage with the inlet guide and the outlet guide when the tubing guard is in a closed position and is configured to expose the rotor sub-assembly, the tubing pressure block, the inlet guide, and the outlet guide when in an open position.
An apheresis system may include an assembly for separating a component from a multi- component fluid, a processor, and a memory storing data for processing by the processor. The data, when processed, may cause the processor to run a calibration test on one or more instruments of the assembly and, based the one or more instruments failing the calibration test, calibrate the one or more instruments or lock the apheresis system for non-use. The apheresis system may include a pump configured to generate a calibration pressure at a test port and a pressure sensor configured to sense a pressure at the test port. The calibration test may include comparing the calibration pressure at the test port to the sensed pressure by the pressure sensor at the test port.
A flexure-based tubing state sensor includes a flexure block and a pressure sensor. The flexure block includes a body with a sensor aperture, a lever arm configured to pivot about a pivot axis between an unpivoted state and a pivoted state and including a tubing contact section and a sensor contact section arranged a first distance from the sensor aperture in the unpivoted state and a second distance from the sensor aperture in the pivoted state, a first flexure, a second flexure, and a fixed wall section disposed offset a tubing gap distance from the tubing contact section of the lever arm. The pressure sensor includes a pressure region adjacent the sensor aperture and in contact with the sensor contact section. The pressure sensor may detect pressure at the tubing contact section via rotation of the lever arm and the sensor contact section acting on the pressure region.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 7/04 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges in the form of flexible, deformable tubes, e.g. Bourdon gauges
F04B 43/08 - Machines, pumps, or pumping installations having flexible working members having tubular flexible members
F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
97.
INTEGRATED CODE SCANNING SYSTEM AND APHERESIS DATA CONTROL METHOD
A method includes receiving, with an apheresis system, data associated with a donor; determining, based on the data associated with a donor, an identification of the donor; receiving, with the apheresis system, data associated with a blood component collection set; receiving, with the apheresis system, data associated with a plasma collection bottle; and performing, with the apheresis system, a plasma donation process based on the identification of the donor, the data associated with the blood component set, and the data associated with the plasma collection bottle. Receiving the data associated with the donor may include scanning, with a scanner, an image. The scanner is disposed on the apheresis system and the image may include one of a one-dimensional barcode or a two-dimensional barcode. The data associated with the donor may be displayed on a user device.
A modular serviceability sled includes a frame, subassembly, interconnection, gasket, and shielding component. The interconnection is operatively connected to the subassembly and includes an electrical, pneumatic, and/or hydraulic connection. The gasket can engage the frame and a base assembly of an apparatus. The shielding component can contact the frame and the base assembly and includes an electromagnetic interference and/or radio frequency shielding component. The sled is movable between an engaged state and a disengaged state. In the engaged state, the sled is at least partially within a receiving space of the apparatus, the gasket engages the frame and the base assembly, the shielding component contacts the frame and the base assembly, and the interconnection is operatively connected to a machine interconnection of the apparatus. In the disengaged state, the interconnection is disconnected from the machine interconnection and the sled is configured to freely move with respect to the base assembly.
A method includes detecting a condition including one or more of a change in flow of a fluid and d change in a composition of the fluid, issuing an alarm in response to the condition detected, lowering a flow rate; and attempting to restart process and increase the flow rate. The change in flow may include a change in pressure. The change in flow may be associated with a collapsed vein. The change in flow of the fluid may include detecting that the flow rate has fallen below a threshold. The change in the composition may be associated with a color. The change in the composition may include using a color sensor to detect one or more of a red, a green, and a blue reflection or transmission to detect red blood cells.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A fluid collection loop includes a flexible tube having a first end and a second end, a connector, and a fluid component collection bladder. The connector is configured to couple the first end of the flexible loop and the fluid component collection bladder. The fluid component collection bladder includes a first chamber defined between a top end and a flow chamber separator, and a second chamber defined between a bottom end and the flow chamber separator. The flow chamber separator extends from a first end of the fluid component collection bladder towards a second end of the fluid component collection bladder and a gap exists between the fluid component collection bladder and the second end of the fluid component collection bladder.
