09 - Appareils et instruments scientifiques et électriques
Produits et services
laboratory equipment, namely welding devices for connecting sections of thermoplastic medical tubing, and welding wafer used in connection therewith; embedded software for managing workflow for loading tubing, initiating welds, and responding to device messages
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
3.
METHODS FOR CELL EXPANSION, DIFFERENTIATION, HARVESTING, ACTIVATION, OR ANY COMBINATION THEREOF USING HOLLOW FIBER MEMBRANES
A method for functionalizing a hollow fiber membrane for cell expansion, differentiation, harvesting, activation, or any combination thereof of target cells (e.g., natural killer cells) includes contacting a biotinylated molecule to a surface of the hollow fiber membrane including an extracellular matrix component, the biotinylated molecule binding to the extracellular matrix component and having an affinity for the target cells. The biotinylated molecule is selected from the group consisting of: cytokine, epitope, ligand, monoclonal antibody, stains, aptamer, and combinations thereof. The extracellular matrix component selected from the group consisting of: fibronectin, vitronectin, fibrinogen, collagen, laminin, streptavidin, truncations thereof, and combinations thereof.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61K 38/00 - Préparations médicinales contenant des peptides
Methods and systems configured to measure content of a target substance in a fluid sample using a refractometer including a light source and a light sensor. A method includes: calibrating the refractometer by identifying a calibration pixel pattern of first pixels of the light sensor illuminated by light from the light source that has reflected off a sensing surface of a container including a reference fluid having a known reference density; identifying a blood pixel pattern of second pixels of the light sensor illuminated by light from the light source that has reflected off the sensing surface when the fluid sample is present in the container; identifying a pixel shift distance along the light sensor from the calibration pixel pattern to the fluid pixel pattern; and determining the content of the target substance in the fluid sample based on the pixel shift distance.
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/41 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique
A61B 5/05 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
5.
METHOD AND SYSTEM FOR DETECTING HEMOLYSIS IN BLOOD USING REFRACTOMETRY
Methods and systems configured to measure content of a target substance in a fluid sample using a refractometer including a light source and a light sensor. A method includes: calibrating the refractometer by identifying a calibration pixel pattern of first pixels of the light sensor illuminated by light from the light source that has reflected off a sensing surface of a container including a reference fluid having a known reference density; identifying a blood pixel pattern of second pixels of the light sensor illuminated by light from the light source that has reflected off the sensing surface when the fluid sample is present in the container; identifying a pixel shift distance along the light sensor from the calibration pixel pattern to the fluid pixel pattern; and determining the content of the target substance in the fluid sample based on the pixel shift distance.
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
A method for determining a flow model for fluid within an apheresis machine includes determining a starting flow model for an apheresis procedure, determining details of a secondary device, and generating an updated flow model based on the starting flow model and the details of the secondary device. The secondary device is configured to connect to the apheresis machine for the apheresis procedure.
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
8.
METHODS AND SYSTEMS FOR DETERMINING FLOW MODELS AND INFUSION RATES FOR APHERESIS SYSTEMS
A method for determining a flow model for fluid within an apheresis machine includes determining a starting flow model for an apheresis procedure, determining details of a secondary device, and generating an updated flow model based on the starting flow model and the details of the secondary device. The secondary device is configured to connect to the apheresis machine for the apheresis procedure.
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
9.
CONTAINERS HAVING BIOCOMPATIBLE INTERIOR SURFACES AND BLOOD PROCESSING SYSTEMS INCLUDING THE SAME
A container, e.g., a bag, for processing whole blood or a whole blood component and a system for processing whole blood or a whole blood component including the container. The container includes a body and an interior chamber. The body has a bulk portion and a surface portion defining an interior surface of the body. The bulk portion of the body is formed from a polymeric composition comprising a thermoplastic polymer. The surface portion of the body includes a biocompatible material that reduces platelet activation, platelet aggregation, or adhesion of platelets to the interior surface of the body. The interior chamber is at least partially defined by the interior surface of the body.
A container, e.g., a bag, for processing whole blood or a whole blood component and a system for processing whole blood or a whole blood component including the container. The container includes a body and an interior chamber. The body has a bulk portion and a surface portion defining an interior surface of the body. The bulk portion of the body is formed from a polymeric composition comprising a thermoplastic polymer. The surface portion of the body includes a biocompatible material that reduces platelet activation, platelet aggregation, or adhesion of platelets to the interior surface of the body. The interior chamber is at least partially defined by the interior surface of the body.
A lyophilization container includes a first section having a first layer, a second layer aligned with the first layer, and a cavity defined by the alignment of the first and second layers, where at least one of the first and second layers is preformed to have a three-dimensional shape. A lyophilization fixture includes a base member and a lid member. The lid member is movable between a first position and a second position relative to the base member. The base member and lid member together define a housing that receives at least a portion of a lyophilization container.
B65D 75/24 - Objets ou matériaux entièrement enveloppés dans des feuilles simples ou des flans enveloppants dans des feuilles ou des flans repliés autour du contenu, et avec leurs bords libres opposés réunis, p. ex. par adhésifs à pression, par pliage, thermosoudage ou soudage la feuille ou le flan étant renfoncés pour épouser la forme du contenu et formés de plusieurs renfoncements pour convenir à une suite d'objets ou à des quantités de matériaux
B65D 65/38 - Matériaux d'emballage de type ou forme particulière
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
B29C 51/10 - Formage par une différence de pression, p. ex. sous vide
B65D 75/52 - Paquets comportant des objets ou matériaux partiellement ou complètement enfermés dans des bandelettes, des feuilles, des flans, des tubes ou des bandes en matériau souple mince, p. ex. dans des enveloppes pliées Détails
A lyophilization container includes a first section having a first layer, a second layer aligned with the first layer, and a cavity defined by the alignment of the first and second layers, where at least one of the first and second layers is preformed to have a three-dimensional shape. A lyophilization fixture includes a base member and a lid member. The lid member is movable between a first position and a second position relative to the base member. The base member and lid member together define a housing that receives at least a portion of a lyophilization container.
F26B 25/00 - Parties constitutives d'application générale non couvertes par un des groupes ou
B65D 65/38 - Matériaux d'emballage de type ou forme particulière
B65D 75/24 - Objets ou matériaux entièrement enveloppés dans des feuilles simples ou des flans enveloppants dans des feuilles ou des flans repliés autour du contenu, et avec leurs bords libres opposés réunis, p. ex. par adhésifs à pression, par pliage, thermosoudage ou soudage la feuille ou le flan étant renfoncés pour épouser la forme du contenu et formés de plusieurs renfoncements pour convenir à une suite d'objets ou à des quantités de matériaux
B65D 75/52 - Paquets comportant des objets ou matériaux partiellement ou complètement enfermés dans des bandelettes, des feuilles, des flans, des tubes ou des bandes en matériau souple mince, p. ex. dans des enveloppes pliées Détails
A lyophilization container includes a first section having a first layer, a second layer aligned with the first layer, and a cavity defined by the alignment of the first and second layers, where at least one of the first and second layers is preformed to have a three-dimensional shape. A lyophilization fixture includes a base member and a lid member. The lid member is movable between a first position and a second position relative to the base member. The base member and lid member together define a housing that receives at least a portion of a lyophilization container.
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
B65D 51/24 - Fermetures non prévues ailleurs combinées avec dispositifs auxiliaires pour des buts autres que la fermeture
F26B 5/04 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide
F26B 25/18 - Chambres, récipients ou réceptacles de structure simple quasi ouverts, p. ex. plats, plateaux, cuves
14.
Methods And Systems For High-Throughput Blood Component Collection
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
A system for receiving and modifying apheresis data includes at least one memory and at least one processor. The at least one memory is configured to store instructions. The at least one processor is configured to execute the instructions and cause the system to receive data from an apheresis machine following completion of an apheresis procedure, process the data to transform the data into a second format, and save the data in the second format into a database. The data received from the apheresis machine is in a first format and the second format is different from the first format.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A system for receiving and modifying apheresis data includes at least one memory and at least one processor. The at least one memory is configured to store instructions. The at least one processor is configured to execute the instructions and cause the system to receive data from an apheresis machine following completion of an apheresis procedure, process the data to transform the data into a second format, and save the data in the second format into a database. The data received from the apheresis machine is in a first format and the second format is different from the first format.
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
17.
FLUID CONTROL AND BYPASS FEATURES FOR AN APHERESIS SYSTEM
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
A method includes detecting a condition including one or more of a change in flow of a fluid and a change in a composition of the fluid, issuing an alarm in response to the condition detected, lowering a flow rate; and attempting to restart process and increase the flow rate. The change in flow may include a change in pressure. The change in flow may be associated with a collapsed vein. The change in flow of the fluid may include detecting that the flow rate has fallen below a threshold. The change in the composition may be associated with a color. Thee change in the composition may include using a color sensor to detect one or more of a red, a green, and a blue reflection or transmission to detect red blood cells.
A method includes: detecting an alarm event associated with an apheresis system; retrieving a graphical presentation output based on the alarm event detected; and rendering the graphical presentation output to a graphical user interface of the apheresis system. In the method, the alarm event can be related to one or more factors, such as: a temperature; a pressure; a flow rate; a color of fluid; and an excessive amount of received plasma. The alarm event can be detected when one of the factors crosses a threshold.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
20.
SAMPLING METHODS AND DEVICES FOR MEDICAL EQUIPMENT
A method for in-line sampling for a medical device includes prompting an operator of a medical device to establish a fluid communication between a fluid component collection set as received by the medical device and a sample system for sample collection, where the medical device prohibits removal of the fluid component collection set or a component thereof from fluid communication with the medical device until sample collection using the sample system is complete and the establishing of fluid communication between the fluid component collection set includes prompting the medical device to interpret a code disposed on an exterior-facing surface of the sample tube.
A method for in-line sampling for a medical device includes prompting an operator of a medical device to establish a fluid communication between a fluid component collection set as received by the medical device and a sample system for sample collection, where the medical device prohibits removal of the fluid component collection set or a component thereof from fluid communication with the medical device until sample collection using the sample system is complete and the establishing of fluid communication between the fluid component collection set includes prompting the medical device to interpret a code disposed on an exterior-facing surface of the sample tube.
A method includes detecting a startup of an apheresis machine; in response to detecting start up, transmitting data to a server; determining, based on the data, whether software of the apheresis machine is current; receiving, in response to the data, a response from the server; and preventing usage of apheresis machine if the response indicates the software is not current. The data transmitted to the server may include one or more of a data log, a firmware version identifier, and an error log. The response may include a lockout signal. The response may include a software update. The software update may include a firmware update. The method may include automatically initiating installation of the software update. The method may include ceasing prevention of usage of the apheresis machine following installation of the software update.
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 60/205 - Pompes pour le sang à déplacement non positif
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
23.
TRACKING AND ANALYZING INFORMATION IN INDIVIDUAL MEDICAL DEVICE TO IDENTIFY POTENTIAL ISSUES
A method for monitoring, analyzing, and adjusting performance of an individual medical device includes collecting, by the individual medical device, performance data of the individual medical device, identifying, by the individual medical device, the at least one variable using the collected performance data, analyzing, by the individual medical device, the at least one variable by comparing the at least one variable to a predetermined threshold, and if the at least one variable is not as expected, at least one of alerting, by the individual medical device, an operator of the individual medical device and adjusting, by the individual medical device, one or more operating parameters for the individual medical device.
A61M 60/538 - Régulation par des données en temps réel de paramètres fonctionnels de la pompe pour le sang, p. ex. par l’intensité du courant d’un moteur
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
24.
TRACKING AND ANALYZING INFORMATION IN INDIVIDUAL MEDICAL DEVICE TO IDENTIFY POTENTIAL ISSUES WITH THE INDIVIDUAL MEDICAL DEVICE AND TO UPDATE THE INDIVIDUAL MEDICAL DEVICE
A method for monitoring, analyzing, and adjusting performance of an individual medical device includes collecting, by the individual medical device, performance data of the individual medical device, identifying, by the individual medical device, the at least one variable using the collected performance data, analyzing, by the individual medical device, the at least one variable by comparing the at least one variable to a predetermined threshold, and if the at least one variable is not as expected, at least one of alerting, by the individual medical device, an operator of the individual medical device and adjusting, by the individual medical device, one or more operating parameters for the individual medical device.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
25.
METHODS FOR DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS USING HOLLOW FIBER BIOREACTORS
A method of differentiating induced pluripotent stem cells using a hollow fiber bioreactor includes obtaining induced pluripotent stem cells in the hollow fiber bioreactor and causing a differentiating medium to move through the hollow fiber bioreactor. In certain variations, the obtaining of the induced pluripotent stem cells may include expanding the induced pluripotent stem cell using the hollow fiber bioreactor. In other variations, the obtaining of the induced pluripotent stem cells may include introducing the induced pluripotent stem cells into the hollow fiber bioreactor.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
26.
METHODS FOR DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS USING HOLLOW FIBER BIOREACTORS
A method of differentiating induced pluripotent stem cells using a hollow fiber bioreactor includes obtaining induced pluripotent stem cells in the hollow fiber bioreactor and causing a differentiating medium to move through the hollow fiber bioreactor. In certain variations, the obtaining of the induced pluripotent stem cells may include expanding the induced pluripotent stem cell using the hollow fiber bioreactor. In other variations, the obtaining of the induced pluripotent stem cells may include introducing the induced pluripotent stem cells into the hollow fiber bioreactor.
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Business management consulting and advisory services for the
medical device industry; excluding advertising, marketing,
and branding services. Training in the use and operation of medical devices and
consultation relating thereto; educational services, namely,
providing classes, seminars, conferences, and workshops in
the field of surgery, medicine and healthcare, and the
distribution of course materials in connection therewith;
none of the foregoing in the fields of psychological and
personal assessment. Medical research; providing technological and scientific
information about medical devices, biotechnology devices and
software development; computer programming and computer
software consulting services in the blood product collection
and plasma-derived product manufacturing industries; none of
the foregoing including publications in the form of tests,
answer forms, report forms, test manuals, sold as a unit or
individually. Technical consulting services in the field of health care
and medicine. Regulatory compliance consulting in the field of medical
devices.
A bag for mixing fluid volumes includes a port at a center of a first end, a second end, a first constriction, and a second constriction. The port is configured to couple to at least one fluid line for introducing and removing fluids from the bag. The second end includes a first lobe and a second lobe. The first constriction is on the first side between the first end and the second end and the second constriction is on a second side between the first end and the second end.
B01F 25/20 - Mélangeurs à jet, c.-à-d. mélangeurs utilisant des courants de fluides à grande vitesse
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
B01F 21/20 - Dissolution utilisant le mélange à écoulement
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
A bag for mixing fluid volumes includes a port at a center of a first end, a second end, a first constriction, and a second constriction. The port is configured to couple to at least one fluid line for introducing and removing fluids from the bag. The second end includes a first lobe and a second lobe. The first constriction is on the first side between the first end and the second end and the second constriction is on a second side between the first end and the second end.
B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides
B01F 31/29 - Mélange en déformant périodiquement les éléments tubulaires souples dans lesquels s'écoule la matière
B01F 35/40 - Montage ou support des dispositifs de mélange ou des récipientsDispositions de serrage ou de maintien à cet effet
B01F 101/44 - Mélange d'ingrédients pour la microbiologie, l'enzymologie, la culture in vitro ou la manipulation génétique
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
(1) Business management consulting and advisory services for the medical device industry; excluding advertising, marketing, and branding services.
(2) Training in the use and operation of medical devices and consultation relating thereto; educational services, namely, providing classes, seminars, conferences, and workshops in the field of surgery, medicine and healthcare, and the distribution of course materials in connection therewith; none of the foregoing in the fields of psychological and personal assessment.
(3) Medical research; providing technological and scientific information about medical devices, biotechnology devices and software development; computer programming and computer software consulting services in the blood product collection and plasma-derived product manufacturing industries; none of the foregoing including publications in the form of tests, answer forms, report forms, test manuals, sold as a unit or individually.
(4) Technical consulting services in the field of health care and medicine.
(5) Regulatory compliance consulting in the field of medical devices.
34.
LOADING, DISTRIBUTING, AND EXPANDING CELLS IN A HOLLOW FIBER BIOREACTOR
A method for using a bioreactor-based system includes circulating a volume including a cell population through a space in a first direction for a first period, the space having a first orientation for the first period; circulating the volume in a second direction for a second period, the space having the first orientation for the second period; circulating the volume in the first direction for a third period, the space having a second orientation for the third period; and circulating the volume in the second direction for a fourth period, the space having the second orientation for the fourth period. The method further includes maintaining a culture medium in the space using bidirectional movement at a first rate, causing the culture medium to move through the space at a second rate that is less than the first rate, and causing a washing fluid to move through the space.
A method for using a bioreactor-based system includes circulating a volume including a cell population through a space in a first direction for a first period, the space having a first orientation for the first period; circulating the volume in a second direction for a second period, the space having the first orientation for the second period; circulating the volume in the first direction for a third period, the space having a second orientation for the third period; and circulating the volume in the second direction for a fourth period, the space having the second orientation for the fourth period. The method further includes maintaining a culture medium in the space using bidirectional movement at a first rate, causing the culture medium to move through the space at a second rate that is less than the first rate, and causing a washing fluid to move through the space.
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, na“i”ve, memory, or effector, for example.
A quick connect, rapid fluid transfer connection includes a first connector having a first end and an opposing second end and a second connector having a first end and an opposing second end, where the second end of the second connector is configured to receive at least a portion of the second end of the first connector. At least one of the first and second connectors includes a check valve. For example, the first connector may include a cavity and a ball movable therewithin. The cavity having a first portion with a first average diameter and a second portion with a second average diameter. The ball having a third average diameter that is smaller than the first average diameter and greater than the second average diameter.
A quick connect, rapid fluid transfer connection includes a first connector having a first end and an opposing second end and a second connector having a first end and an opposing second end, where the second end of the second connector is configured to receive at least a portion of the second end of the first connector. At least one of the first and second connectors includes a check valve. For example, the first connector may include a cavity and a ball movable therewithin. The cavity having a first portion with a first average diameter and a second portion with a second average diameter. The ball having a third average diameter that is smaller than the first average diameter and greater than the second average diameter.
A fusion bonding wafer includes a first substrate formed in a flat plate shape, a second substrate joined to an inner surface of the first substrate, a heating element formed between the inner surface of the first substrate and an inner surface of the second substrate, and a temperature measurement hole that penetrates through the second substrate in a thickness direction thereof and exposes the inner surface of the first substrate.
A separation device for separating a separation target from a liquid includes a pump, a first valve, a second valve, and a controller. The pump is configured to cause a first liquid containing an antibody or an aptamer capable of specifically binding to an antigen of the separation target and a second liquid containing the separation target to pass through a base material made of a porous polyester or a porous polyurethane capable of binding to the antibody or the aptamer. The first valve may be configured to open and close a first flow path through which the first liquid flows. The second valve may be configured to open and close a second flow path through which the second liquid flows. The controller is configured to control operation of the pump, opening and closing of the first valve, and opening and closing of the second valve.
A filter includes a base material made of a porous polyurethane having a plurality of micropores and an active group fixed to a surface of the base material. The active group is capable of specifically binding to a separation target.
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
A method for preparing chimeric antigen receptor cells using a cell expansion system includes introducing target cells to a bioreactor of the cell expansion system, where the introduction of the target cells includes isolating the target cells from a source. The isolation of the target cells from the source includes contacting the source to one or more identifying component and then causing the source to move through a separating column, where the separating column disposed in the cell expansion system in line with the bioreactor. The method further includes introducing viral vectors to the bioreactor, introducing a transduction reagent to the bioreactor, and removing non-cellular material from the bioreactor by causing material in the bioreactor to flow through a bypass loop, where the bypass loop includes one or more size exclusion filters and the non-cellular material includes unused viral vectors and unused identifying components.
A method for preparing chimeric antigen receptor cells using a cell expansion system includes introducing target cells to a bioreactor of the cell expansion system, where the introduction of the target cells includes isolating the target cells from a source. The isolation of the target cells from the source includes contacting the source to one or more identifying component and then causing the source to move through a separating column, where the separating column disposed in the cell expansion system in line with the bioreactor. The method further includes introducing viral vectors to the bioreactor, introducing a transduction reagent to the bioreactor, and removing non-cellular material from the bioreactor by causing material in the bioreactor to flow through a bypass loop, where the bypass loop includes one or more size exclusion filters and the non-cellular material includes unused viral vectors and unused identifying components.
G06F 8/71 - Gestion de versions Gestion de configuration
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance
46.
SYSTEMS AND METHODS FOR CONTROLLING SOFTWARE UPDATES FOR A COLLECTION OF APHERESIS DEVICES
A method for remotely transferring a software package to a group of apheresis systems includes transferring the software package to a first apheresis system of the group and transferring the software package from the first apheresis system to remaining apheresis systems in the group.
A method for remotely transferring a software package to a group of apheresis systems includes transferring the software package to a first apheresis system of the group and transferring the software package from the first apheresis system to remaining apheresis systems in the group.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance
G06F 8/71 - Gestion de versions Gestion de configuration
48.
CONNECTIVITY SET FOR CONNECTING A POST-PROCESSING UNIT TO AN APHERESIS DEVICE
A medical system may include a separation device configured to separate a material received from a source into two or more components, a post-processing unit in fluid communication with the separation device and configured to isolate at least one of the two or more components, and a controller configured to manage operation of the separation device to separate the material received from the source into the two or more components, to cause the two or more components to move to the post-processing unit, and to return the isolated at least one of the two or more components to the separation device.
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
A shelfing structure for use during the precipitation of one or more components from a composite includes a support and one or more expression plates movably coupled to the support, where each of the one or more expression plates is movable between a first position and a second position, and each of the one or more expression plates is configured to receive one or more bags of a bag assembly. A method for separating one or more components from a composite may include positioning the shelfing structure holding one or more bag assemblies in an environment having a thawing temperature. Each of the one or more bag assemblies may include a first bag including the composite in a frozen state and a second bag configured to receive the one or more components. The shelfing structure may be configured to hold the second bag above the first bag in each instance.
The present disclosure provides a means for separating specific cells from among a plurality of types of cells having sizes close to those of the specific cells. Disclosed is a filter through which a liquid containing a cell or protein that is an object to be separated is allowed to pass to capture the object. The filter comprises: a substrate comprising a porous polyurethane in which a plurality of micropores are formed; and an active group fixed to the surface of the substrate and capable of specifically binding to the object. The active group contains: a constituent unit A bound to the substrate and derived from a compound A having an epoxy group and an ethylenically unsaturated group; and a constituent unit B bound to the constituent unit A and derived from first biotin.
A medical system may include a separation device configured to separate a material received from a source into two or more components, a post-processing unit in fluid communication with the separation device and configured to isolate at least one of the two or more components, and a controller configured to manage operation of the separation device to separate the material received from the source into the two or more components, to cause the two or more components to move to the post-processing unit, and to return the isolated at least one of the two or more components to the separation device.
A shelfing structure for use during the precipitation of one or more components from a composite includes a support and one or more expression plates movably coupled to the support, where each of the one or more expression plates is movable between a first position and a second position, and each of the one or more expression plates is configured to receive one or more bags of a bag assembly. A method for separating one or more components from a composite may include positioning the shelfing structure holding one or more bag assemblies in an environment having a thawing temperature. Each of the one or more bag assemblies may include a first bag including the composite in a frozen state and a second bag configured to receive the one or more components. The shelfing structure may be configured to hold the second bag above the first bag in each instance.
A method for collecting blood components includes separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from the whole blood as available after the separation of the first amount of plasma; if a total collected amount is less than a maximum as adjusted by real-time data regarding collection following the separation of the total amount of platelets, separating a second amount of plasma from the whole blood as available after the separation of the total amount of platelets and then separating a total amount of red blood cells from the whole blood as available after the separation of the second amount of plasma; and if the total collected amount is at the maximum as adjusted by real-time data regarding collection, separating the total amount of red blood cells from the whole blood as available after the separation of the total amount of platelets.
A method for using an automated blood collection system to collect blood components from a subject includes separating plasma from whole blood as received from the subject; initiating an alert when a predicted accumulated volume loss is greater than a configured removal level, the predicted accumulated volume loss depending on an accumulated volume that includes the separated volume of plasma and the configured removal level being defined by a hypovolemic level or the pre-selected maximum for the subject; and in response to the alert and feedback from an operator of the automated blood collection system, ending the collection process, continuing the collection, or initiating platelet and red blood cell separation.
A method for using an automated blood collection system to collect blood components from a subject includes separating plasma from whole blood as received from the subject; initiating an alert when a predicted accumulated volume loss is greater than a configured removal level, the predicted accumulated volume loss depending on an accumulated volume that includes the separated volume of plasma and the configured removal level being defined by a hypovolemic level or the pre-selected maximum for the subject; and in response to the alert and feedback from an operator of the automated blood collection system, ending the collection process, continuing the collection, or initiating platelet and red blood cell separation.
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
A61M 60/113 - Pompes extracorporelles, c.-à-d. que le sang est pompé à l’extérieur du corps du patient incorporées dans des circuits ou des systèmes sanguins extracorporels dans d’autres dispositifs fonctionnels, p. ex. dialyseurs ou cœurs-poumons artificiels
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
A method for collecting blood components includes separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from the whole blood as available after the separation of the first amount of plasma; if a total collected amount is less than a maximum as adjusted by real-time data regarding collection following the separation of the total amount of platelets, separating a second amount of plasma from the whole blood as available after the separation of the total amount of platelets and then separating a total amount of red blood cells from the whole blood as available after the separation of the second amount of plasma; and if the total collected amount is at the maximum as adjusted by real-time data regarding collection, separating the total amount of red blood cells from the whole blood as available after the separation of the total amount of platelets.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable and installable medical software for formatting
and transferring data from a medical device to an on-site
information database; downloadable and installable computer
software for transferring data from a medical device to an
on-site information database; downloadable and installable
communication software to access a medical device stored on
a blood or blood component device and transfer data to
another device; downloadable and installable medical device
software for transfer of data; downloadable and installable
computer software for management of device run data;
downloadable and installable computer software for use in
formatting and transferring device run data; downloadable
and installable computer software for use in the field of
medical device data management; downloadable and installable
computer software specialized for use in data management to
enterprises worldwide in the medical industry; downloadable
and installable computer software for connecting multiple
devices or information databases, bidirectional
communication with information management systems and
devices, storing and managing electronic data. Computer services, specifically involving the formatting and
transfer of run data from automated blood collection systems
to an information database.
61.
APPARATUSES, SYSTEMS, AND METHODS FOR PLASMA RINSEBACK
A system for minimizing a residual blood value via a plasma rinseback includes a collection bag, a return reservoir, one or more pumps, and one or more lines. The collection bag is configured to store plasma collected from a donor during a donation process. The return reservoir is configured to collect fluid remaining in the system after the donation process is complete. The one or more pumps are configured to be actuated between an operational state and a nonoperational state during the donation process and the plasma rinseback. The one or more lines are configured to couple the collection bag, the return reservoir, the one or more pumps, and the donor. The system is configured to complete the plasma rinseback to return fluid within the system to the donor after the donation process is complete.
A system for minimizing a residual blood value via a plasma rinseback includes a collection bag, a return reservoir, one or more pumps, and one or more lines. The collection bag is configured to store plasma collected from a donor during a donation process. The return reservoir is configured to collect fluid remaining in the system after the donation process is complete. The one or more pumps are configured to be actuated between an operational state and a nonoperational state during the donation process and the plasma rinseback. The one or more lines are configured to couple the collection bag, the return reservoir, the one or more pumps, and the donor. The system is configured to complete the plasma rinseback to return fluid within the system to the donor after the donation process is complete.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Business management consulting and advisory services for the medical device industry; excluding advertising, marketing, and branding services Training in the use and operation of medical devices and consultation relating thereto; Educational services, namely, providing classes, seminars, conferences, and workshops in the field of surgery, medicine and healthcare, and the distribution of course materials in connection therewith; none of the foregoing in the fields of psychological and personal assessment Medical research; Providing technological and scientific information about medical devices, biotechnology devices and software development; computer programming and computer software consulting services in the blood product collection and plasma-derived product manufacturing industries; none of the foregoing including publications in the form of tests, answer forms, report forms, test manuals, sold as a unit or individually Technical consulting services in the field of health care and medicine Regulatory compliance consulting in the field of medical devices
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
A method for producing T-cells using a cell expansion system includes expanding T-cells using a small bioreactor of the cell expansion system, the small bioreactor having a surface area of about 2,000 cm2 and an intracapillary volume of about 58 milliliters. The method further includes causing T-cells to flow into a small bioreactor of the cell expansion system. A rate at which the T-cells flow into the small bioreactor may be greater than or equal to about 0.007 μL/min/fiber to less than or equal to about 0.0281 μL/min/fiber. The cell expansion system may further include a tubing set that is in fluid communication with the small bioreactor and a volume ratio of the tubing set to the bioreactor may be about 2.96.
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A method for producing T-cells using a cell expansion system includes expanding T-cells using a small bioreactor of the cell expansion system, the small bioreactor having a surface area of about 2,000 cm2 and an intracapillary volume of about 58 milliliters. The method further includes causing T-cells to flow into a small bioreactor of the cell expansion system. A rate at which the T-cells flow into the small bioreactor may be greater than or equal to about 0.007 μL/min/fiber to less than or equal to about 0.0281 μL/min/fiber. The cell expansion system may further include a tubing set that is in fluid communication with the small bioreactor and a volume ratio of the tubing set to the bioreactor may be about 2.96.
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
68.
PREFORMED LYOPHILIZATION CONTAINERS AND METHODS OF PREPARING THE SAME
A lyophilization container includes a first section having a first layer, a second layer aligned with the first layer, and a cavity defined by the alignment of the first and second layers, where at least one of the first and second layers is preformed to have a three-dimensional shape. A lyophilization fixture includes a base member and a lid member. The lid member is movable between a first position and a second position relative to the base member. The base member and lid member together define a housing that receives at least a portion of a lyophilization container.
B65D 75/24 - Objets ou matériaux entièrement enveloppés dans des feuilles simples ou des flans enveloppants dans des feuilles ou des flans repliés autour du contenu, et avec leurs bords libres opposés réunis, p. ex. par adhésifs à pression, par pliage, thermosoudage ou soudage la feuille ou le flan étant renfoncés pour épouser la forme du contenu et formés de plusieurs renfoncements pour convenir à une suite d'objets ou à des quantités de matériaux
B29C 51/10 - Formage par une différence de pression, p. ex. sous vide
B65D 65/38 - Matériaux d'emballage de type ou forme particulière
B65D 75/52 - Paquets comportant des objets ou matériaux partiellement ou complètement enfermés dans des bandelettes, des feuilles, des flans, des tubes ou des bandes en matériau souple mince, p. ex. dans des enveloppes pliées Détails
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
69.
Methods To Remove Solutes Without Suspension Cell Loss
A method for removing solutes while retaining suspension cells within a bioreactor includes positioning a suspension including cells within a predetermined region of the bioreactor and causing a flow rate across the suspension in the bioreactor, where the flow rate is selected to cause the solutes to move out of the bioreactor while the cells are maintained in the bioreactor.
A method for removing solutes while retaining suspension cells within a bioreactor includes positioning a suspension including cells within a predetermined region of the bioreactor and causing a flow rate across the suspension in the bioreactor, where the flow rate is selected to cause the solutes to move out of the bioreactor while the cells are maintained in the bioreactor.
A method for collection blood component using a medical system includes receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including a subject's initial hematocrit; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system determined using the subject hematocrit, a total blood volume for the subject, and a targeted change in hematocrit; and performing, using the medical system, a component donation process to collect the identified subject-specific pure component amount to be collected.
A method for collection blood component using a medical system includes receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including a subject's initial hematocrit; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system determined using the subject hematocrit, a total blood volume for the subject, and a targeted change in hematocrit; and performing, using the medical system, a component donation process to collect the identified subject-specific pure component amount to be collected.
A tube clamp arrangement includes a first mounting plate and a second mounting plate. The first mounting plate is configured to join together a first tube-holding assembly and a first adjustment mechanism, where the first adjustment mechanism is configured to move in a first direction in a first plane. The second mounting plate is configured to join together a second tube-holding assembly and a second adjustment mechanism, where the second adjustment mechanism is configured to move in a second direction in the first plane.
B23K 37/04 - Dispositifs ou procédés auxiliaires non spécialement adaptés à un procédé couvert par un seul des autres groupes principaux de la présente sous-classe pour maintenir ou mettre en position les pièces
An assembly for testing a quality of a weld joining a first section of tubing to a second section of the tubing includes a track, a first tubing engagement structure coupled to the track and translatable along the track, a second tubing engagement structure connected to the track, an actuator, and a load cell. The actuator is operable to translate the first tubing engagement structure along the track in a first direction toward the second tubing engagement structure and in a second direction away from the second tubing engagement structure. The load cell is operable to measure at least one of a compression load and a tensile load applied to the tubing by the first and second tubing engagement structures.
G01N 3/10 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression engendrés par pression pneumatique ou hydraulique
B23K 31/02 - Procédés relevant de la présente sous-classe, spécialement adaptés à des objets ou des buts particuliers, mais non couverts par un seul des groupes principaux relatifs au brasage ou au soudage
G01M 3/28 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par mesure du taux de perte ou de gain d'un fluide, p. ex. avec des dispositifs réagissant à la pression, avec des indicateurs de débit pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par mesure du taux de perte ou de gain d'un fluide, p. ex. avec des dispositifs réagissant à la pression, avec des indicateurs de débit pour raccords ou joints d'étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par mesure du taux de perte ou de gain d'un fluide, p. ex. avec des dispositifs réagissant à la pression, avec des indicateurs de débit pour soupapes
A tube clamp arrangement includes a first mounting plate and a second mounting plate. The first mounting plate is configured to join together a first tube-holding assembly and a first adjustment mechanism, where the first adjustment mechanism is configured to move in a first direction in a first plane. The second mounting plate is configured to join together a second tube-holding assembly and a second adjustment mechanism, where the second adjustment mechanism is configured to move in a second direction in the first plane.
An assembly for testing a quality of a weld joining a first section of tubing to a second section of the tubing includes a track, a first tubing engagement structure coupled to the track and translatable along the track, a second tubing engagement structure connected to the track, an actuator, and a load cell. The actuator is operable to translate the first tubing engagement structure along the track in a first direction toward the second tubing engagement structure and in a second direction away from the second tubing engagement structure. The load cell is operable to measure at least one of a compression load and a tensile load applied to the tubing by the first and second tubing engagement structures.
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
A tube opening device may include a mounting base defining a tube-receiving cavity, a first tube-engaging surface extending into the tube-receiving cavity, a first linear-motion actuator secured to the mounting base and configured to move the first tube-engaging surface between the first retracted position and a first extended position, a second tube-engaging surface extending into the tube-receiving cavity, a second linear-motion actuator secured to the mounting base and configured to move the second tube-engaging surface between the second retracted position and a second extended position, a third tube-engaging surface extending into the tube-receiving cavity, and a third linear-motion actuator secured to the mounting base and configured to move the third tube-engaging surface between the third retracted position and a third extended position.
A method of initiating a tube joining process includes receiving, with a tube joining device, data associated with a cartridge. The method further includes determining whether the cartridge is authentic based on the data. The method further includes, in response to a determination that the cartridge is authentic, initiating the tube joining process. A method of verifying media combination protocol includes verifying a first media bag. The verifying includes receiving, with a tube joining device, first data associated with the first media bag. The receiving includes concurrently scanning, with a scanner, a first plurality of items. The method further includes mapping the first plurality of items to a first plurality of predetermined fields. The method further includes, after the mapping, determining whether a first predetermined condition is met.
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
G06K 7/14 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire utilisant la lumière sans sélection des longueurs d'onde, p. ex. lecture de la lumière blanche réfléchie
83.
Tube Joining Device With Modular Accessories And Protocol Assurance
A tube joining device includes a housing, a first subassembly, and a second subassembly. The housing defines an interior region. The housing includes a first contact. The first contact is electrically conductive. The first subassembly includes a tube joining subassembly. The tube joining subassembly is at least partially in the interior region. The second subassembly is configured to be coupled to the housing. The second subassembly includes a second contact. The second contact is electrically conductive. The second subassembly is configured to be coupled to the housing by an elongated dovetail joint. The first contact is configured to be in electrical communication with the second contact to form a connection including a ground connection, a data connection, a power connection, or any combination thereof.
A tube-joining device for joining two flexible tube sections including a tube holder configured to hold the flexible tube sections in place for joining. The tube holder may have a clamped and a non-clamped configuration. The tube holder may have a start and a finish configuration. The tube holder may have tube detectors. When certain criteria are met, the tube holder may automatically begin a tube-joining operation, or may automatically return itself from the finish to the start configuration, or the tube-joining device may automatically begin heating a blade used for cutting and melting the tubes.
A tube-joining device for joining two flexible tube sections including a tube holder configured to hold the flexible tube sections in place for joining. The tube holder may have a clamped and a non-clamped configuration. The tube holder may have a start and a finish configuration. The tube holder may have tube detectors. When certain criteria are met, the tube holder may automatically begin a tube-joining operation, or may automatically return itself from the finish to the start configuration, or the tube-joining device may automatically begin heating a blade used for cutting and melting the tubes.
A tube opening device may include a mounting base defining a tube-receiving cavity, a first tube-engaging surface extending into the tube-receiving cavity, a first linear-motion actuator secured to the mounting base and configured to move the first tube-engaging surface between the first retracted position and a first extended position, a second tube-engaging surface extending into the tube-receiving cavity, a second linear-motion actuator secured to the mounting base and configured to move the second tube-engaging surface between the second retracted position and a second extended position, a third tube-engaging surface extending into the tube-receiving cavity, and a third linear-motion actuator secured to the mounting base and configured to move the third tube-engaging surface between the third retracted position and a third extended position.
A method of initiating a tube joining process includes receiving, with a tube joining device, data associated with a cartridge. The method further includes determining whether the cartridge is authentic based on the data. The method further includes, in response to a determination that the cartridge is authentic, initiating the tube joining process. A method of verifying media combination protocol includes verifying a first media bag. The verifying includes receiving, with a tube joining device, first data associated with the first media bag. The receiving includes concurrently scanning, with a scanner, a first plurality of items. The method further includes mapping the first plurality of items to a first plurality of predetermined fields. The method further includes, after the mapping, determining whether a first predetermined condition is met.
A tube joining device includes a housing, a first subassembly, and a second subassembly. The housing defines an interior region. The housing includes a first contact. The first contact is electrically conductive. The first subassembly includes a tube joining subassembly. The tube joining subassembly is at least partially in the interior region. The second subassembly is configured to be coupled to the housing. The second subassembly includes a second contact. The second contact is electrically conductive. The second subassembly is configured to be coupled to the housing by an elongated dovetail joint. The first contact is configured to be in electrical communication with the second contact to form a connection including a ground connection, a data connection, a power connection, or any combination thereof.
A61M 39/14 - Raccords ou accouplements pour tubes pour connecter des tubes ayant des extrémités obturées
A61M 39/18 - Procédés ou appareils pour réaliser les connexions sous conditions stériles
H01R 13/22 - Contacts pour coopération par aboutage
H01R 13/28 - Contacts destinés à coopérer par glissement avec un contact de forme identique, p. ex. pour des dispositifs de couplage hermaphrodites
H01R 13/514 - SoclesBoîtiers formés comme un bloc ou un assemblage modulaire, c.-à-d. composés de parties coopérantes pourvues de pièces de contact ou maintenant entre elles des pièces de contact
A tube opening device includes a body having a first side and a second side and including a tube-receiving cavity. The first side of the body includes a first belt system disposed on a first side of the tube-receiving cavity and a second belt system disposed on a second side of the tube-receiving cavity. The first and second belt systems are configured to apply pressure to a tube received in the tube-receiving cavity to open temporary seals and form a continuous tube.
A tube welding device for joining tubes includes a first tube-holding assembly configured to receive a first portion of a first tube and a first portion of a second tube, and a second tube-holding assembly configured to receive a second portion of the first tube and a second portion of the second tube. The first tube-holding assembly includes a first detector, and the second tube-holding assembly includes a second detector. The first and second detectors are configured to detect the presence or absence of fluid in the respective tubes and to generate signals indicative of the same. The tube welding device includes a controller configured to receive the signals, to select an appropriate tube-joining temperature in response to the presence or absence of fluid in the first and second tubes, and to cause an appropriate power level to be sent to a wafer to generate the tube-joining temperature.
A tube welding device for joining tubes includes a first tube-holding assembly configured to receive a first portion of a first tube and a first portion of a second tube, and a second tube-holding assembly configured to receive a second portion of the first tube and a second portion of the second tube. The first tube-holding assembly includes a first detector, and the second tube-holding assembly includes a second detector. The first and second detectors are configured to detect the presence or absence of fluid in the respective tubes and to generate signals indicative of the same. The tube welding device includes a controller configured to receive the signals, to select an appropriate tube-joining temperature in response to the presence or absence of fluid in the first and second tubes, and to cause an appropriate power level to be sent to a wafer to generate the tube-joining temperature.
B29C 65/20 - Assemblage d'éléments préformésAppareils à cet effet par chauffage, avec ou sans pressage avec un outil chauffé à contact direct, p. ex. avec un "miroir"
A tube opening device includes a body having a first side and a second side and including a tube-receiving cavity. The first side of the body includes a first belt system disposed on a first side of the tube-receiving cavity and a second belt system disposed on a second side of the tube-receiving cavity. The first and second belt systems are configured to apply pressure to a tube received in the tube-receiving cavity to open temporary seals and form a continuous tube.
G06F 21/51 - Contrôle des utilisateurs, des programmes ou des dispositifs de préservation de l’intégrité des plates-formes, p. ex. des processeurs, des micrologiciels ou des systèmes d’exploitation au stade du chargement de l’application, p. ex. en acceptant, en rejetant, en démarrant ou en inhibant un logiciel exécutable en fonction de l’intégrité ou de la fiabilité de la source
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
96.
BLOOD COMPONENT COLLECTION SET WITH INTEGRATED SAFETY FEATURES
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G16H 40/00 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
99.
METHODS AND INTERFACES FOR PROVIDING DONATION PROCESS FEEDBACK
A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.
G16H 40/00 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
100.
BLOOD COMPONENT COLLECTION SET WITH INTEGRATED SAFETY FEATURES
A separation assembly for an apheresis system includes a first media bag, a second media mag, a vessel, and a separation set. The first media bag contains a first fluid medium. The second media bag contains a second fluid medium. The vessel is configured to contain a third fluid medium. The separation set includes a first tube and a second tube. The first tube has a first fitting that is configured to be coupled to the first media bag. The first tube defines a first length. The second tube has a second fitting that is configured to be coupled to the second media bag. The second tube defines a second length different from the first length. The separation set may further includes a third tube is configured to be coupled to the vessel.
