Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
The present disclosure relates to compositions and methods for treating red blood cells compositions with a pathogen-inactivation compound and for preparing pathogen-inactivated red blood cells.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group
A61L 2/24 - Apparatus using programmed or automatic operation
(1) Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
11.
MODULAR LIGHT DEVICE FOR A BIOLOGICAL FLUID TREATMENT SYSTEM
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Blood plasma products for medical purposes; Pathogen inactivated blood and blood plasma products for medical use; Pathogen reduced blood plasma products for use in connection with transfusions; Pathogen reduced blood products, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products for medical use
18.
CRYOPRECIPITATE COMPOSITIONS AND METHODS OF PREPARATION THEREOF
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
A61J 1/18 - Arrangements for indicating condition of container contents, e.g. sterile condition
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 38/36 - Blood coagulation or fibrinolysis factors
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Blood products for medical purposes, namely, for the treatment and control of bleeding; Pathogen inactivated blood for medical use; pathogen inactivated blood products for medical use, namely, for the treatment and control of bleeding; Pathogen reduced blood products for use in connection with transfusions, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products; Pathogen reduced blood products, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products for medical use
20.
System and methods for implementing a biological fluid treatment device
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
G06F 3/0481 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61L 2/24 - Apparatus using programmed or automatic operation
23.
SYSTEMS AND METHODS FOR IMPLEMENTING TREATMENT OF BIOLOGICAL FLUIDS
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
26.
SYSTEM AND METHODS FOR IMPLEMENTING A BIOLOGICAL FLUID TREATMENT DEVICE
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61L 2/24 - Apparatus using programmed or automatic operation
H04L 69/08 - Protocols for interworkingProtocol conversion
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
G06F 3/0481 - Interaction techniques based on graphical user interfaces [GUI] based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
G06F 3/0482 - Interaction with lists of selectable items, e.g. menus
Medical devices for use in the preparation of pathogen inactivated blood products; blood processing apparatus, namely, blood processing devices; medical processing kits consisting primarily of medical tubing and containers for the production of pathogen reduced blood products; medical apparatus, namely, processing containers for cryoprecipitation and the production of cryoprecipitate, cryoprecipitated fibrinogen complex and cryoprecipitate reduced plasma
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Blood and blood components for medical purposes; biological preparations for medical purposes; compositions for use in the processing and storage of blood products for transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in biological preparations for medical purposes; chemical compositions for medical use, namely for controlling or preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components and biological preparations; solutions for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits; blood components; blood plasma; human plasma protein; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes. Computer software for managing the production and processing of blood and blood components; computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; computer software and hardware for the operation of ultraviolet illumination devices; database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; laboratory equipment for analyzing, testing and processing blood and blood components; downloadable electronic publications; videocasts; podcasts; computer software relating to the medical field. Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components; medical instruments; medical apparatus and devices; apparatus for blood analysis; blood testing apparatus; blood testing equipment.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded Computer software for managing the production and processing of blood and blood components; recorded computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; recorded computer software and hardware for the operation of ultraviolet illumination devices; recorded database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; recorded computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; recorded computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; recorded computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; laboratory equipment for analyzing, testing and processing blood and blood components
Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Blood and blood components for medical purposes, namely, platelets, plasma, and red blood cells; biological preparations for use in connection with the processing, storage, and treatment of blood; compositions for use in the processing and storage of blood products for transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in biological preparations for medical purposes; chemical compositions for medical use, namely, for controlling or preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components and biological preparations; solutions for the production of blood components, namely, platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits
34.
METHODS AND KITS FOR PREPARING PATHOGEN-INACTIVATED WHOLE BLOOD
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
A61L 2/24 - Apparatus using programmed or automatic operation
38.
SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group
39.
SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
H01L 25/075 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers the devices being of a type provided for in group
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Blood and blood components, treated to inactivate or reduce pathogens; compositions for use in the processing and storage of blood products; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells; compositions for medical use for controlling or preventing cell proliferation or nucleic acid replication; Preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood products; chemical preparations for medical or pharmaceutical purposes; biological preparations for medical purposes; preparations for the production of blood products and the inactivation of pathogens, cells and nucleic acids in such blood products. Blood processing apparatus; devices for use in the inactivation of pathogens, cells and nucleic acids in blood and blood products; medical processing kits primarily consisting of tubing, containers, bags, equipment and ultraviolet light boxes for the production of blood components, such as platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components; medical processing instruments, namely, blood processing instruments and ultraviolet illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components; Apparatus, equipment and instruments for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; parts and fittings for the aforesaid. Production of blood and blood components, treated to inactivate or reduce pathogens; production of pathogen-inactivated or pathogen-reduced blood products; conducting research in the field of blood, blood components and blood transfusion safety; advisory, consultancy and information services in relation to blood safety and production of pathogen-inactivated or pathogen-reduced blood and blood products.
41.
COMPOSITIONS AND METHODS FOR IMPROVED NK CELL THERAPIES
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
The present disclosure relates to compositions and methods for treating red blood cells compositions with a pathogen-inactivation compound and for preparing pathogen-inactivated red blood cells.
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A01N 37/44 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio-analogue of a carboxylic group, e.g. amino-carboxylic acids
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Blood and blood components for medical purposes, namely, platelets, plasma and red blood cells; reagents for processing and storage of blood and blood components in tubing, containers and bags for use in transfusions in the medical field; reagents for the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions in the medical field; chemical compositions for medical use, namely, for preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions in the medical field; chemical compositions for medical use, namely, for controlling cell proliferation or nucleic acid replication; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components; solutions for the production of blood components, namely, platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits, all for medical or pharmaceutical purposes
53.
Compositions and methods for improved car-T cell therapies
The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Provided herein are improved processes for preparing and treating platelet products. The methods are useful in the efficient preparation of platelet products with desirable characteristics, including pathogen inactivated platelet products.
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
A61J 1/18 - Arrangements for indicating condition of container contents, e.g. sterile condition
A61K 9/00 - Medicinal preparations characterised by special physical form
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
09 - Scientific and electric apparatus and instruments
Goods & Services
Computer software for managing the production and processing of blood and blood components; computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; computer software and hardware for the operation of illumination devices; database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components
Medical processing instruments, namely, blood processing instruments and illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid
The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
The present disclosure provides compositions and methods for the treatment of viral hemorrhagic fever. The compositions and methods are useful for treating hemorrhagic fever virus infections and conditions associated with such infections.
Provided herein are improved processes for preparing and treating platelet products. The methods are useful in the efficient preparation of platelet products with desirable characteristics, including pathogen inactivated platelet products.
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Blood and blood components, namely, platelets, plasma and
red blood cells; compositions for use in the inactivation of
pathogens in blood and blood products. Blood processing apparatus; apparatus for pooling of blood
components; medical processing kits primarily consisting of
plastic tubing, containers, solutions, equipment and
ultraviolet light boxes for the production of blood
components and the inactivation of viruses, bacteria and
other pathogens in such blood components; medical processing
instruments, namely, blood processing instruments and
ultraviolet light boxes for the production of blood
components, and inactivation of viruses, bacteria and other
pathogens in such blood components. Product development and implementation consulting services
in the field of production of blood products; product
development consulting in the field of blood components,
namely, platelets, plasma and red blood cells; providing
scientific consultation in the fields of blood processing
and production of blood products; technological consultation
in the fields of blood processing and production, treatment,
pathogen reduction and storage of blood products.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Compositions for use in the inactivation of pathogens in blood and blood components, such as platelets, plasma and red blood cells, for use in connection with blood transfusions; Medical processing instruments, namely, ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma, and red blood cells, for use in connection with blood transfusions; medical processing kits primarily consisting of plastic tubing, containers, solutions and ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma and red blood cells, for use in connection with blood transfusions
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Blood and blood components, namely, platelets, plasma and red blood cells; compositions for use in the processing and storage of blood products; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells; compositions for medical use for preventing cell proliferation or nucleic acid replication; Preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; compositions for medical use for controlling cell proliferation or nucleic acid replication; chemical preparations for medical or pharmaceutical purposes; biological preparations for medical purposes; solutions for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits. Software and hardware for the operation of illumination devices; computer software for controlling medical instruments, namely blood processing instruments and ultraviolet illumination devices; database management software for use in the medical, veterinary, life science and pharmaceutical fields; computer software for managing the production and processing of blood and blood components; downloadable publications, videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, diagnostic and medical use; computer software for use in the medical, veterinary, life science and pharmaceutical fields; laboratory equipment for analysing, testing and processing blood and blood components. Blood processing apparatus; devices for use in the inactivation of pathogens, cells and nucleic acids in blood and blood products; medical processing kits primarily consisting of tubing, containers, bags, equipment and ultraviolet light boxes for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components; medical processing instruments, namely, blood processing instruments and ultraviolet illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components; Apparatus, equipment and instruments for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; parts and fittings for the aforesaid.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Blood and blood components, namely, platelets, plasma and red blood cells; Compositions for use in the inactivation of pathogens in blood and blood products; Solutions for the production of blood components and the inactivation of viruses, bacteria and other pathogens in such blood components, all being components of medical processing kits. Blood processing apparatus; Apparatus for pooling of blood components; Medical processing kits primarily consisting of plastic tubing, containers, equipment and ultraviolet light boxes for the production of blood components and the inactivation of viruses, bacteria and other pathogens in such blood components; Medical processing instruments, namely, blood processing instruments and ultraviolet light boxes for the production of blood components, and inactivation of viruses, bacteria and other pathogens in such blood components. Product development and implementation consulting services in the field of production of blood products; Product development consulting in the field of blood components, namely, platelets, plasma and red blood cells; Providing scientific consultation in the fields of blood processing and production of blood products; Technical consultation in the fields of blood processing and production, treatment, pathogen reduction and storage of blood products.
Medical devices, namely, medical light boxes, containers and
synthetic tubing for blood or other bodily fluids; medical
devices applied to blood/bodily fluid products; filters and
compound removal devices for use in the inactivation of
pathogens and cells for medical or diagnostic use; devices
for use in the processing and storage of blood products for
medical or diagnostic use; devices for use in
catheterization procedures for medical or diagnostic use and
for preventing cell proliferation and nucleic acid
replication for medical or diagnostic use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions.
75.
Quenching methods for red blood cell pathogen inactivation
The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.
A01N 1/00 - Preservation of bodies of humans or animals, or parts thereof
A61L 2/16 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor using chemical substances
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, namely, compositions for use in the
inactivation of pathogens and cells for medical or
diagnostic use; compositions for use in the processing and
storage of blood products; compositions for medical or
diagnostic use for preventing cell proliferation or nucleic
acid replication.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions. Medical processing instruments, namely, ultraviolet light
boxes for the inactivation of viruses, bacteria and other
pathogens in blood and blood components such as platelets,
plasma, and red blood cells, for use in connection with
blood transfusions; medical processing kits primarily
consisting of plastic tubing, containers, solutions and
ultraviolet light boxes for the inactivation of viruses,
bacteria and other pathogens in blood and blood components
such as platelets, plasma and red blood cells, for use in
connection with blood transfusions.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions. Medical processing instruments, namely, ultraviolet light
boxes for the inactivation of viruses, bacteria and other
pathogens in blood and blood components such as platelets,
plasma, and red blood cells, for use in connection with
blood transfusions; medical processing kits primarily
consisting of plastic tubing, containers, solutions and
ultraviolet light boxes for the inactivation of viruses,
bacteria and other pathogens in blood and blood components
such as platelets, plasma and red blood cells, for use in
connection with blood transfusions.
79.
IMPROVED QUENCHING METHODS FOR RED BLOOD CELL PATHOGEN INACTIVATION
The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
80.
IMPROVED QUENCHING METHODS FOR RED BLOOD CELL PATHOGEN INACTIVATION
The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.
A01N 43/42 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Medical processing kits and instruments for the pathogen inactivation of blood and blood components, namely, plastic tubing, containers, solutions, and illumination devices, namely, a device which delivers/exposes the blood component to ultraviolet A light source which activates the chemical reaction to inactivate white blood cells, viruses, parasites and bacteria in the collected human platelet component.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical or diagnostic use; chemical and pharmaceutical compositions for use in the processing and storage of blood products; diagnostic preparations for medical or diagnostic use in the fields of immunodiagnostics and molecular diagnostics; chemical and pharmaceutical compositions for medical or diagnostic use for preventing or controlling cell proliferation or nucleic acid replication; vaccines for human use; chemical and pharmaceutical compositions for inactivation or alteration of pathogens or cells for use in manufacturing vaccines; devices, namely, medical light boxes, containers, and synthetic tubing for blood or other bodily fluids; chemical reagents for use in medical and biological studies; filters for use in the inactivation of pathogens and cells for medical or diagnostic use; filters for use in the processing and storage of blood products for medical or diagnostic use; filters for use in the fields of immunodiagnostics and molecular diagnostics for medical or diagnostic use; filters for preventing or controlling cell proliferation and nucleic acid replication for medical or diagnostic use; devices for use in manufacturing vaccines, namely, medical light boxes.
The present invention provides nucleic acid constructs comprising a nucleotide sequence encoding an EphA2 antigenic peptide and Listeria comprising such constructs. In particular, the present invention provides Listeria engineered to express a plurality of EphA2 antigenic peptides and immunogenic compositions comprising such Listeria. The invention encompasses, inter alia, the use of the immunogenic compositions for eliciting an immune response against an EphA2-expressing cell, as well as for the treatment, management and/or prevention of a hyperproliferative disorder and/or a disease involving aberrant angiogenesis.
C12P 1/00 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
84.
LISTERIA-INDUCED IMMUNORECRUITMENT AND ACTIVATION, AND METHODS OF USE THEREOF
Provided are reagents and methods for administering an attenuated bacterium for use in treating a cancerous or infectious condition. Reagents and methods for administering an attenuated bacterium for use in inducing an immune response against a tumor, cancer cell, or infective agent are further provided. Also provided are methods of diagnosis and kits.
Provided are reagents and methods for administering an attenuated bacterium and a binding compound for treating a cancerous or infectious condition, where the binding compound comprises an antibody or an antigen binding site derived from an antibody.
Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.
Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.
C12N 5/078 - Cells from blood or from the immune system
A61L 2/16 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor using chemical substances
C07K 5/02 - Peptides having up to four amino acids in a fully defined sequenceDerivatives thereof containing at least one abnormal peptide link
C12N 7/06 - Inactivation or attenuationProducing viral sub-units by chemical treatment
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Compositions for use in the inactivation of pathogens in blood and blood components, such as platelets, plasma and red blood cells, for use in connection with blood transfusions Medical processing instruments, namely, ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma, and red blood cells, for use in connection with blood transfusions; medical processing kits primarily consisting of plastic tubing, containers, solutions and ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma and red blood cells, for use in connection with blood transfusions
MEDICAL PROCESSING INSTRUMENTS, namely, ULTRAVIOLET LIGHT BOXES FOR THE INACTIVATION OF VIRUSES, BACTERIA AND OTHER PATHOGENS IN BLOOD AND BLOOD COMPONENTS, namely, PLATELETS, PLASMA [ AND RED BLOOD CELLS ], FOR BLOOD TRANSFUSIONS
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Solutions; solutions for use in connection with the pathogen inactivation of blood and blood components; flexible containers which initially contain solutions for processing blood. Software and hardware for the operation of the illumination devices. Tubing, plastic tubing, illumination devices (for medical use), disposable medical kits; needles, syringes, tubing, bags, compound absorption devices, containers (for medical use); containers used to store the collected blood products whilst they are being illuminated by illumination devices; plastic flexible containers used for processing and absorbing photo products after illumination; plastic flexible containers for storage of final treated blood products; compound solution apparatus for medical use; parts and fittings for the aforesaid goods.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Compositions for use in the inactivation of pathogens and cells for scientific or research use; diagnostic preparations for scientific or research use in the fields of immunodiagnostics and molecular diagnostics; compositions for scientific or research use for preventing cell proliferation and nucleic acid replication. Pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical or diagnostic use; compositions for use in the processing and storage of blood products; compositions, namely, psoralens and other compounds that prevent cell proliferation or nucleic acid replication for use with a catheter in surgical procedures; diagnostic preparations for medical or diagnostic use in the fields of immunodiagnostics and molecular diagnostics; compositions for medical or diagnostic use for preventing cell proliferation or nucleic acid replication; vaccines. Apparatus for scientific research in the fields of molecular biology and immunology. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials; including, devices for use in the inactivation of pathogens and cells, devices for use in the processing and storage of blood products, devices for use in catheterization procedures, devices for use in the fields of immunodiagnostics and molecular diagnostics, devices for preventing cell proliferation and nucleic acid replication, and devices for use in the manufacturing vaccines.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical [or diagnostic] use; compositions for use in the processing and storage of blood products; [ compositions, namely, psoralens and other compounds that prevent cell proliferation of nucleic acid replication for use with a catheter in surgical procedures; diagnostic preparations for medical [ or diagnostic ] use in the fields of immunodiagnostics and molecular diagnostics; ] compositions for medical or diagnostic use for preventing cell proliferation or nucleic acid replication [ ; vaccines ]
devices, namely, medical light boxes, containers and synthetic tubing for blood or other bodily fluids, applied to blood/bodily fluid products, filters, compound removal devices [and catheters] for use in the inactivation of pathogens and cells for medical or diagnostic use; for use in the processing and storage of blood products for medical or diagnostic use; for use in catheterization procedures for medical or diagnostic use;[ for use in the fields of immunodiagnostics and molecular diagnostics for medical or diagnostic ] use; and for preventing cell proliferation and nucleic acid replication for medical or diagnostic use
