Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
A61J 1/18 - Dispositions pour indiquer l'état, p. ex. l'état stérile, du contenu du récipient
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 38/36 - Facteurs de coagulation sanguine ou de fibrinolyse
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
B01F 31/00 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
Provided are methods and systems for the pathogen inactivation of blood products and compositions, including methods of using devices (e.g., comprising component(s) configured to control flow of fluid(s)) to determine the amount of pathogen inactivation compound (PIC) necessary for pathogen inactivation of a blood composition (e.g., based at least in part on one or more input parameters) and allow transfer of the blood composition and the PIC into a container, e.g., of a processing set.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
G01N 5/00 - Analyse des matériaux par pesage, p. ex. pesage des fines particules séparées d'un gaz ou d'un liquide
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
4.
SYSTEMS AND METHODS FOR PATHOGEN INACTIVATION OF BLOOD PRODUCTS
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
6.
SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A01N 1/124 - Agents désinfectants, p. ex. antimicrobiens
A01N 1/168 - Procédés physiques de conservation utilisant des champs ou des radiations électromagnétiquesProcédés physiques de conservation utilisant des ondes acoustiques ou des radiations corpusculaires
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
H01L 25/075 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans le groupe
7.
SYSTEMS AND METHODS FOR TESTING AND SCREENING USING COMPOUND BOUND SUBSTRATES
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Blood products, namely, platelets, plasma, red blood cells, cryoprecipitate and fibrinogen complex for medical purposes; pathogen inactivated blood for medical purposes; pathogen inactivated blood products, namely, platelets, plasma, red blood cells, cryoprecipitated plasma and fibrinogen complex for medical purposes; pathogen reduced blood products, namely, platelets, plasma, red blood cells, cryoprecipitate and fibrinogen complex for medical purposes.
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
B01F 31/00 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
The present disclosure relates to compositions and methods for treating red blood cells compositions with a pathogen-inactivation compound and for preparing pathogen-inactivated red blood cells.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
H01L 25/075 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans le groupe
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
(1) Medical processing instruments, namely, instruments for the production of blood components and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical devices comprising solution containers, treatment containers, storage containers and pathogen inactivation compound, and instruments for fluid delivery and illumination with ultraviolet light for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices comprising ultraviolet light sources for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus comprising solution containers, treatment containers, storage containers and pathogen inactivation compound, and instruments for fluid delivery and illumination with ultraviolet light for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
19.
MODULAR LIGHT DEVICE FOR A BIOLOGICAL FLUID TREATMENT SYSTEM
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
Provided herein are systems and methods for implementing a modular light device for use in an electronic treatment device according to examples of the disclosure. In one or more examples, the modular light device can be implemented as a stand-alone component that can be swapped in and out of the treatment device. In one or more examples, the light device can include a light source array chamber configured to transmit UV light of a selected wavelength, the light source array chamber including one or more light source arrays and light sensors collectively configured as part of the light device to deliver light to a biological sample.
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
22.
Kits and methods for preparing pathogen-inactivated platelet compositions
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
23.
METHODS AND KITS FOR PREPARING PATHOGEN-INACTIVATED WHOLE BLOOD
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Blood plasma products for medical purposes; Pathogen inactivated blood and blood plasma products for medical use; Pathogen reduced blood plasma products for use in connection with transfusions; Pathogen reduced blood products, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products for medical use
26.
Cryoprecipitate compositions and methods of preparation thereof
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
A61J 1/18 - Dispositions pour indiquer l'état, p. ex. l'état stérile, du contenu du récipient
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 38/36 - Facteurs de coagulation sanguine ou de fibrinolyse
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Blood products for medical purposes, namely, for the treatment and control of bleeding; Pathogen inactivated blood for medical use; pathogen inactivated blood products for medical use, namely, for the treatment and control of bleeding; Pathogen reduced blood products for use in connection with transfusions, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products; Pathogen reduced blood products, namely, plasma, cryoprecipitate, fibrinogen complex, and cryoprecipitated fibrinogen complex products for medical use
28.
System and methods for implementing a biological fluid treatment device
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
B01F 31/00 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants
B01F 101/23 - Mélange d'échantillons de laboratoire, p. ex. en vue d'analyser ou de tester les propriétés des matières
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
G06F 3/0481 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] fondées sur des propriétés spécifiques de l’objet d’interaction affiché ou sur un environnement basé sur les métaphores, p. ex. interaction avec des éléments du bureau telles les fenêtres ou les icônes, ou avec l’aide d’un curseur changeant de comportement ou d’aspect
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
31.
SYSTEMS AND METHODS FOR IMPLEMENTING TREATMENT OF BIOLOGICAL FLUIDS
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
34.
SYSTEM AND METHODS FOR IMPLEMENTING A BIOLOGICAL FLUID TREATMENT DEVICE
Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
H04L 69/08 - Protocoles d’interopérabilitéConversion de protocole
Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
Disclosed herein are systems and methods for implementing a plurality of graphical user interfaces. In one or more examples, an electronic device can include a display that provides the users with a series of graphical user interfaces, each graphical user interface corresponding to one or more of a plurality steps that a user can engage in to operate the electronic device. The one or more graphical user interfaces can include a visual depiction of what the user should be doing to operate the device at a given time, and can provide the user with information necessary such as processing status and identification information of the material being treated so as to operate the device. In one or more examples, the plurality of graphical user interfaces can place data and information of the screen that corresponds to the physical layout of the electronic device.
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
G06F 3/04817 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] fondées sur des propriétés spécifiques de l’objet d’interaction affiché ou sur un environnement basé sur les métaphores, p. ex. interaction avec des éléments du bureau telles les fenêtres ou les icônes, ou avec l’aide d’un curseur changeant de comportement ou d’aspect utilisant des icônes
G06F 3/0482 - Interaction avec des listes d’éléments sélectionnables, p. ex. des menus
Medical devices for use in the preparation of pathogen inactivated blood products; blood processing apparatus, namely, blood processing devices; medical processing kits consisting primarily of medical tubing and containers for the production of pathogen reduced blood products; medical apparatus, namely, processing containers for cryoprecipitation and the production of cryoprecipitate, cryoprecipitated fibrinogen complex and cryoprecipitate reduced plasma
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Blood and blood components for medical purposes; biological preparations for medical purposes; compositions for use in the processing and storage of blood products for transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in biological preparations for medical purposes; chemical compositions for medical use, namely for controlling or preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components and biological preparations; solutions for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits; blood components; blood plasma; human plasma protein; chemical preparations for medical purposes; chemical preparations for pharmaceutical purposes. Computer software for managing the production and processing of blood and blood components; computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; computer software and hardware for the operation of ultraviolet illumination devices; database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; laboratory equipment for analyzing, testing and processing blood and blood components; downloadable electronic publications; videocasts; podcasts; computer software relating to the medical field. Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components; medical instruments; medical apparatus and devices; apparatus for blood analysis; blood testing apparatus; blood testing equipment.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Recorded Computer software for managing the production and processing of blood and blood components; recorded computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; recorded computer software and hardware for the operation of ultraviolet illumination devices; recorded database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; recorded computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; recorded computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; recorded computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components; laboratory equipment for analyzing, testing and processing blood and blood components
Medical processing instruments, namely, instruments and illumination devices for the production of blood components and biological preparations and the inactivation of pathogens, cells and nucleic acids in such blood components and biological preparations, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; ultraviolet illumination devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; medical processing apparatus for use in the treatment, pathogen inactivation, storage or reconstitution of blood and blood components
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Blood and blood components for medical purposes, namely, platelets, plasma, and red blood cells; biological preparations for use in connection with the processing, storage, and treatment of blood; compositions for use in the processing and storage of blood products for transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions; compositions for use in the inactivation of pathogens, cells and nucleic acids in biological preparations for medical purposes; chemical compositions for medical use, namely, for controlling or preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components and biological preparations; solutions for the production of blood components, namely, platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits
42.
METHODS AND KITS FOR PREPARING PATHOGEN-INACTIVATED WHOLE BLOOD
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
H01L 25/075 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans le groupe
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
46.
SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
H01L 25/075 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans le groupe
47.
SYSTEMS AND METHODS FOR TREATING BIOLOGICAL FLUIDS
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Blood and blood components, treated to inactivate or reduce pathogens; compositions for use in the processing and storage of blood products; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells; compositions for medical use for controlling or preventing cell proliferation or nucleic acid replication; Preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood products; chemical preparations for medical or pharmaceutical purposes; biological preparations for medical purposes; preparations for the production of blood products and the inactivation of pathogens, cells and nucleic acids in such blood products. Blood processing apparatus; devices for use in the inactivation of pathogens, cells and nucleic acids in blood and blood products; medical processing kits primarily consisting of tubing, containers, bags, equipment and ultraviolet light boxes for the production of blood components, such as platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components; medical processing instruments, namely, blood processing instruments and ultraviolet illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components; Apparatus, equipment and instruments for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; parts and fittings for the aforesaid. Production of blood and blood components, treated to inactivate or reduce pathogens; production of pathogen-inactivated or pathogen-reduced blood products; conducting research in the field of blood, blood components and blood transfusion safety; advisory, consultancy and information services in relation to blood safety and production of pathogen-inactivated or pathogen-reduced blood and blood products.
49.
COMPOSITIONS AND METHODS FOR IMPROVED NK CELL THERAPIES
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
Provided are methods, kits, and compositions for preparing platelet compositions suitable for infusion, including improved methods, compositions, and kits for pathogen inactivation of an apheresis-derived preparation of platelets.
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
54.
KITS AND METHODS FOR PREPARING PATHOGEN-INACTIVATED PLATELET COMPOSITIONS
The present disclosure relates to compositions and methods for treating red blood cells compositions with a pathogen-inactivation compound and for preparing pathogen-inactivated red blood cells.
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
The present disclosure provides compositions, methods, kits and systems for detecting antibodies in a biological sample. In some embodiments, methods/systems are particularly useful for detecting antibodies in patients against pathogen-inactivating compound treated RBCs.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
A01N 25/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles
A01N 43/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons condensés avec des carbocycles
A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un groupe carboxylique, p. ex. acides aminocarboxyliques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Blood and blood components for medical purposes, namely, platelets, plasma and red blood cells; reagents for processing and storage of blood and blood components in tubing, containers and bags for use in transfusions in the medical field; reagents for the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells for use in connection with transfusions in the medical field; chemical compositions for medical use, namely, for preventing cell proliferation or nucleic acid replication; chemical preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components for use in connection with transfusions in the medical field; chemical compositions for medical use, namely, for controlling cell proliferation or nucleic acid replication; chemical preparations for medical or pharmaceutical purposes, namely, for the inactivation of pathogens, cells and nucleic acids in blood and blood components; solutions for the production of blood components, namely, platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits, all for medical or pharmaceutical purposes
61.
Compositions and methods for improved car-T cell therapies
The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 38/00 - Préparations médicinales contenant des peptides
62.
COMPOSITIONS AND METHODS FOR IMPROVED NK CELL THERAPIES
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Provided herein are improved processes for preparing and treating platelet products. The methods are useful in the efficient preparation of platelet products with desirable characteristics, including pathogen inactivated platelet products.
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
67.
Cryoprecipitate compositions and methods of preparation thereof
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61K 41/17 - Inactivation ou décontamination d'une préparation médicinale avant son administration à un animal ou une personne par lumière ultraviolette [UV] ou infrarouge [IR], rayons X ou rayons gamma
A61J 1/18 - Dispositions pour indiquer l'état, p. ex. l'état stérile, du contenu du récipient
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
68.
CRYOPRECIPITATE COMPOSITIONS AND METHODS OF PREPARATION THEREOF
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software for managing the production and processing of blood and blood components; computer software for controlling medical instruments, namely, blood processing instruments and illumination devices; computer software and hardware for the operation of illumination devices; database management software for managing the production and processing of blood and blood components for use in the medical, life science and pharmaceutical fields; electronic downloadable publications, namely, newsletters and reports on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; downloadable videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, and medical use, namely, for use in the production and processing of blood and blood components; computer software for use in the medical, life science and pharmaceutical fields, namely, for use in the production and processing of blood and blood components
Medical processing instruments, namely, blood processing instruments and illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid; blood processing apparatus, namely, blood processing devices; medical devices for use in the inactivation of pathogens, cells and nucleic acids, and parts and fittings for the aforesaid; Medical processing kits consisting primarily of medical tubing, containers, bags, and removal devices for the production of blood components, namely, for the production of platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, and parts and fittings for the aforesaid
The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
The present disclosure provides compositions and methods for the treatment of viral hemorrhagic fever. The compositions and methods are useful for treating hemorrhagic fever virus infections and conditions associated with such infections.
C07K 16/34 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des antigènes de groupes sanguins
Provided herein are improved processes for preparing and treating platelet products. The methods are useful in the efficient preparation of platelet products with desirable characteristics, including pathogen inactivated platelet products.
A01N 43/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons condensés avec des carbocycles
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Blood and blood components, namely, platelets, plasma and
red blood cells; compositions for use in the inactivation of
pathogens in blood and blood products. Blood processing apparatus; apparatus for pooling of blood
components; medical processing kits primarily consisting of
plastic tubing, containers, solutions, equipment and
ultraviolet light boxes for the production of blood
components and the inactivation of viruses, bacteria and
other pathogens in such blood components; medical processing
instruments, namely, blood processing instruments and
ultraviolet light boxes for the production of blood
components, and inactivation of viruses, bacteria and other
pathogens in such blood components. Product development and implementation consulting services
in the field of production of blood products; product
development consulting in the field of blood components,
namely, platelets, plasma and red blood cells; providing
scientific consultation in the fields of blood processing
and production of blood products; technological consultation
in the fields of blood processing and production, treatment,
pathogen reduction and storage of blood products.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Compositions for use in the inactivation of pathogens in blood and blood components, such as platelets, plasma and red blood cells, for use in connection with blood transfusions; Medical processing instruments, namely, ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma, and red blood cells, for use in connection with blood transfusions; medical processing kits primarily consisting of plastic tubing, containers, solutions and ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma and red blood cells, for use in connection with blood transfusions
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Blood and blood components, namely, platelets, plasma and red blood cells; compositions for use in the processing and storage of blood products; compositions for use in the inactivation of pathogens, cells and nucleic acids in blood and blood components, such as platelets, plasma and red blood cells; compositions for medical use for preventing cell proliferation or nucleic acid replication; Preparations for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; compositions for medical use for controlling cell proliferation or nucleic acid replication; chemical preparations for medical or pharmaceutical purposes; biological preparations for medical purposes; solutions for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components, sold as part of medical processing kits. Software and hardware for the operation of illumination devices; computer software for controlling medical instruments, namely blood processing instruments and ultraviolet illumination devices; database management software for use in the medical, veterinary, life science and pharmaceutical fields; computer software for managing the production and processing of blood and blood components; downloadable publications, videocasts and podcasts on the subject of medicine, blood and blood components and processes and equipment for treating blood and blood components; computer software for clinical, laboratory, diagnostic and medical use; computer software for use in the medical, veterinary, life science and pharmaceutical fields; laboratory equipment for analysing, testing and processing blood and blood components. Blood processing apparatus; devices for use in the inactivation of pathogens, cells and nucleic acids in blood and blood products; medical processing kits primarily consisting of tubing, containers, bags, equipment and ultraviolet light boxes for the production of blood components, namely platelets, plasma and red blood cells, and the inactivation of pathogens, cells and nucleic acids in such blood components; medical processing instruments, namely, blood processing instruments and ultraviolet illumination devices for the production of blood components and inactivation of pathogens, cells and nucleic acids in such blood components; Apparatus, equipment and instruments for use in the testing, treatment, pathogen reduction, storage or reconstitution of blood and blood components; parts and fittings for the aforesaid.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Blood and blood components, namely, platelets, plasma and red blood cells; Compositions for use in the inactivation of pathogens in blood and blood products; Solutions for the production of blood components and the inactivation of viruses, bacteria and other pathogens in such blood components, all being components of medical processing kits. Blood processing apparatus; Apparatus for pooling of blood components; Medical processing kits primarily consisting of plastic tubing, containers, equipment and ultraviolet light boxes for the production of blood components and the inactivation of viruses, bacteria and other pathogens in such blood components; Medical processing instruments, namely, blood processing instruments and ultraviolet light boxes for the production of blood components, and inactivation of viruses, bacteria and other pathogens in such blood components. Product development and implementation consulting services in the field of production of blood products; Product development consulting in the field of blood components, namely, platelets, plasma and red blood cells; Providing scientific consultation in the fields of blood processing and production of blood products; Technical consultation in the fields of blood processing and production, treatment, pathogen reduction and storage of blood products.
Medical devices, namely, medical light boxes, containers and
synthetic tubing for blood or other bodily fluids; medical
devices applied to blood/bodily fluid products; filters and
compound removal devices for use in the inactivation of
pathogens and cells for medical or diagnostic use; devices
for use in the processing and storage of blood products for
medical or diagnostic use; devices for use in
catheterization procedures for medical or diagnostic use and
for preventing cell proliferation and nucleic acid
replication for medical or diagnostic use.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions.
83.
Quenching methods for red blood cell pathogen inactivation
The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.
A01N 1/00 - Conservation de corps humains ou animaux, ou de parties de ceux-ci
A61L 2/16 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques
A01N 43/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons condensés avec des carbocycles
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceuticals, namely, compositions for use in the
inactivation of pathogens and cells for medical or
diagnostic use; compositions for use in the processing and
storage of blood products; compositions for medical or
diagnostic use for preventing cell proliferation or nucleic
acid replication.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions. Medical processing instruments, namely, ultraviolet light
boxes for the inactivation of viruses, bacteria and other
pathogens in blood and blood components such as platelets,
plasma, and red blood cells, for use in connection with
blood transfusions; medical processing kits primarily
consisting of plastic tubing, containers, solutions and
ultraviolet light boxes for the inactivation of viruses,
bacteria and other pathogens in blood and blood components
such as platelets, plasma and red blood cells, for use in
connection with blood transfusions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Compositions for use in the inactivation of pathogens in
blood and blood components, such as platelets, plasma and
red blood cells, for use in connection with blood
transfusions. Medical processing instruments, namely, ultraviolet light
boxes for the inactivation of viruses, bacteria and other
pathogens in blood and blood components such as platelets,
plasma, and red blood cells, for use in connection with
blood transfusions; medical processing kits primarily
consisting of plastic tubing, containers, solutions and
ultraviolet light boxes for the inactivation of viruses,
bacteria and other pathogens in blood and blood components
such as platelets, plasma and red blood cells, for use in
connection with blood transfusions.
87.
IMPROVED QUENCHING METHODS FOR RED BLOOD CELL PATHOGEN INACTIVATION
The present invention provides improved methods for treating red blood cell compositions with a pathogen-inactivating compound under conditions which provide suitable pathogen inactivation while maintaining cell vitality. Also provided methods of reducing dehydration in red blood cells, as well as treated red blood cell compositions.
A01N 43/42 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons condensés avec des carbocycles
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Medical processing kits and instruments for the pathogen inactivation of blood and blood components, namely, plastic tubing, containers, solutions, and illumination devices, namely, a device which delivers/exposes the blood component to ultraviolet A light source which activates the chemical reaction to inactivate white blood cells, viruses, parasites and bacteria in the collected human platelet component.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical or diagnostic use; chemical and pharmaceutical compositions for use in the processing and storage of blood products; diagnostic preparations for medical or diagnostic use in the fields of immunodiagnostics and molecular diagnostics; chemical and pharmaceutical compositions for medical or diagnostic use for preventing or controlling cell proliferation or nucleic acid replication; vaccines for human use; chemical and pharmaceutical compositions for inactivation or alteration of pathogens or cells for use in manufacturing vaccines; devices, namely, medical light boxes, containers, and synthetic tubing for blood or other bodily fluids; chemical reagents for use in medical and biological studies; filters for use in the inactivation of pathogens and cells for medical or diagnostic use; filters for use in the processing and storage of blood products for medical or diagnostic use; filters for use in the fields of immunodiagnostics and molecular diagnostics for medical or diagnostic use; filters for preventing or controlling cell proliferation and nucleic acid replication for medical or diagnostic use; devices for use in manufacturing vaccines, namely, medical light boxes.
90.
Quenching methods for red blood cell inactivation process
Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.
Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.
A61L 2/16 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
C12N 5/078 - Cellules du sang ou du système immunitaire
C12N 7/06 - Inactivation ou atténuationProduction de parties élémentaires de virus par traitement chimique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Compositions for use in the inactivation of pathogens in blood and blood components, such as platelets, plasma and red blood cells, for use in connection with blood transfusions Medical processing instruments, namely, ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma, and red blood cells, for use in connection with blood transfusions; medical processing kits primarily consisting of plastic tubing, containers, solutions and ultraviolet light boxes for the inactivation of viruses, bacteria and other pathogens in blood and blood components such as platelets, plasma and red blood cells, for use in connection with blood transfusions
MEDICAL PROCESSING INSTRUMENTS, namely, ULTRAVIOLET LIGHT BOXES FOR THE INACTIVATION OF VIRUSES, BACTERIA AND OTHER PATHOGENS IN BLOOD AND BLOOD COMPONENTS, namely, PLATELETS, PLASMA [ AND RED BLOOD CELLS ], FOR BLOOD TRANSFUSIONS
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Solutions; solutions for use in connection with the pathogen inactivation of blood and blood components; flexible containers which initially contain solutions for processing blood. Software and hardware for the operation of the illumination devices. Tubing, plastic tubing, illumination devices (for medical use), disposable medical kits; needles, syringes, tubing, bags, compound absorption devices, containers (for medical use); containers used to store the collected blood products whilst they are being illuminated by illumination devices; plastic flexible containers used for processing and absorbing photo products after illumination; plastic flexible containers for storage of final treated blood products; compound solution apparatus for medical use; parts and fittings for the aforesaid goods.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Compositions for use in the inactivation of pathogens and cells for scientific or research use; diagnostic preparations for scientific or research use in the fields of immunodiagnostics and molecular diagnostics; compositions for scientific or research use for preventing cell proliferation and nucleic acid replication. Pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical or diagnostic use; compositions for use in the processing and storage of blood products; compositions, namely, psoralens and other compounds that prevent cell proliferation or nucleic acid replication for use with a catheter in surgical procedures; diagnostic preparations for medical or diagnostic use in the fields of immunodiagnostics and molecular diagnostics; compositions for medical or diagnostic use for preventing cell proliferation or nucleic acid replication; vaccines. Apparatus for scientific research in the fields of molecular biology and immunology. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials; including, devices for use in the inactivation of pathogens and cells, devices for use in the processing and storage of blood products, devices for use in catheterization procedures, devices for use in the fields of immunodiagnostics and molecular diagnostics, devices for preventing cell proliferation and nucleic acid replication, and devices for use in the manufacturing vaccines.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
pharmaceuticals, namely, compositions for use in the inactivation of pathogens and cells for medical [or diagnostic] use; compositions for use in the processing and storage of blood products; [ compositions, namely, psoralens and other compounds that prevent cell proliferation of nucleic acid replication for use with a catheter in surgical procedures; diagnostic preparations for medical [ or diagnostic ] use in the fields of immunodiagnostics and molecular diagnostics; ] compositions for medical or diagnostic use for preventing cell proliferation or nucleic acid replication [ ; vaccines ]
devices, namely, medical light boxes, containers and synthetic tubing for blood or other bodily fluids, applied to blood/bodily fluid products, filters, compound removal devices [and catheters] for use in the inactivation of pathogens and cells for medical or diagnostic use; for use in the processing and storage of blood products for medical or diagnostic use; for use in catheterization procedures for medical or diagnostic use;[ for use in the fields of immunodiagnostics and molecular diagnostics for medical or diagnostic ] use; and for preventing cell proliferation and nucleic acid replication for medical or diagnostic use
