This invention relates to a tool holder apparatus, a method of working an object and a tool, particularly for single point diamond turning (SPOT). The tool holder apparatus typically comprises: a tool holder which comprises: a base; a tool support extending from the base; a seat for a tool provided on the tool support, wherein the tool is locatable in the seat, in use; a sensor arrangement configured to generate electrical measurement signals indicative of, or associated with, at least an applied force to the tool, in use; and a piezoelectric actuator arrangement comprising at least one piezoelectric actuator operatively connected to the tool support, wherein the at least one piezoelectric actuator is configured to displace the tool support, or at least a part thereof, in use, in response to receiving suitable electrical control signal/s thereby to maintain a desired applied force to the tool, in use.
G05B 19/404 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control arrangements for compensation, e.g. for backlash, overshoot, tool offset, tool wear, temperature, machine construction errors, load, inertia
B23Q 15/18 - Compensation of tool-deflection due to temperature or force
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
The invention provides a system for performing distraction osteogenesis of a hand or other anatomical extremity. The system includes a proximal bone fixture component configured to engage a proximal portion of a bone segment, and a movable distractor component which can be positioned distal of the proximal bone fixture component and which is configured to engage a region of the hand located distal of the bone portion engaged by the bone fixture component. Drive means are provided for applying a distraction force between the bone fixture component and the distractor component, and a control component is provided to control operation of the drive means automatically. The drive means can be operated in a continuous manner. A user interface module is provided and can be separated from the control component after the system's operating parameters have been set. The invention also provides a method of performing distraction osteogenesis automatically.
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/24 - Compound rotorcraft, i.e. aircraft using in flight the features of both aeroplane and rotorcraft with rotor blades fixed in flight to act as lifting surfaces
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
This invention provides a flow synthesis process for producing sulfonylurea compounds of formula (1), including gliclazide, chlorpropamide and tolbutamide, and pharmaceutically acceptable salts thereof.
C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
C07C 303/40 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
C07C 311/58 - Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
C07D 209/52 - Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
7.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF SULFONYLUREA COMPOUNDS
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
C07C 303/40 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
C07C 311/59 - Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
C07D 241/24 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
8.
SYSTEM AND METHOD FOR PERFORMING DISTRACTION OSTEOGENESIS
The invention provides a system for performing distraction osteogenesis of a hand or other anatomical extremity. The system includes a proximal bone fixture component configured to engage a proximal portion of a bone segment, and a movable distractor component which can be positioned distal of the proximal bone fixture component and which is configured to engage a region of the hand located distal of the bone portion engaged by the bone fixture component. Drive means are provided for applying a distraction force between the bone fixture component and the distractor component, and a control component is provided to control operation of the drive means automatically. The drive means can be operated in a continuous manner. A user interface module is provided and can be separated from the control component after the system's operating parameters have been set. The invention also provides a method of performing distraction osteogenesis automatically.
A device and method are provided for peening a surface. The peening device comprises a rotatable member, a flexible line that extends from the rotatable member and a peening element that is provided on the flexible line. In use, the line and peening element are rotated about the rotatable member such that when the peening element comes into contact with the surface, the surface is peened as result of kinetic energy of the peening element.
B24B 39/02 - Burnishing machines or devices, i.e. requiring pressure members for compacting the surface zoneAccessories therefor designed for working internal surfaces of revolution
B24B 39/00 - Burnishing machines or devices, i.e. requiring pressure members for compacting the surface zoneAccessories therefor
10.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF OSELTAMIVIR
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
A combination of cannabinoids, and a pharmaceutical composition comprising the combination, for use in the treatment of cancer is provided. In one embodiment the invention relates to a synergistic combination of cannabinoids (THC:CBG:CBN:CBD), a pharmaceutical composition comprising the combination, and the use of the combination or pharmaceutical composition in the treatment of cancer, in particular breast cancer.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/28 - Compound rotorcraft, i.e. aircraft using in flight the features of both aeroplane and rotorcraft with forward-propulsion propellers pivotable to act as lifting rotors
B64C 29/00 - Aircraft capable of landing or taking-off vertically, e.g. vertical take-off and landing [VTOL] aircraft
B64C 39/02 - Aircraft not otherwise provided for characterised by special use
B64D 27/02 - Aircraft characterised by the type or position of power plants
B64D 29/04 - Power-plant nacelles, fairings or cowlings associated with fuselages
13.
A VERTICAL TAKE-OFF AND LANDING AIRCRAFT, METHODS AND SYSTEMS FOR CONTROLLING A VERTICAL TAKE-OFF AND LANDING AIRCRAFT
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/28 - Compound rotorcraft, i.e. aircraft using in flight the features of both aeroplane and rotorcraft with forward-propulsion propellers pivotable to act as lifting rotors
B64C 29/00 - Aircraft capable of landing or taking-off vertically, e.g. vertical take-off and landing [VTOL] aircraft
B64D 27/24 - Aircraft characterised by the type or position of power plants using steam or spring force
B64D 29/04 - Power-plant nacelles, fairings or cowlings associated with fuselages
B64D 27/02 - Aircraft characterised by the type or position of power plants
B64C 39/02 - Aircraft not otherwise provided for characterised by special use
14.
A CONTINUOUS FLOW SYNTHESIS METHOD FOR THE MANUFACTURE OF ISONIAZID
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
A device and method are provided for peening a surface. The peening device comprises a rotatable member, a flexible line that extends from the rotatable member and a peening element that is provided on the flexible line. In use, the line and peening element are rotated about the rotatable member such that when the peening element comes into contact with the surface, the surface is peened as result of kinetic energy of the peening element.
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
C07C 233/52 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
18.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF OSELTAMIVIR
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
C07C 233/52 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
2 containing gas bubbles passing upwards in each of the photobioreactor columns. One or more paddle wheels or jet pumps induce a flow of liquid growth medium within the raceway.
The present invention provides for an extract that is produced from pomace obtained from an Olea europaea fruit oil production process. The extract comprises a mixture of oil-soluble and water-soluble compounds including hydroxytyrosol, tyrosol, oleuropein, αtocopherol, and squalene. The invention further provides for a method of producing the extract, and formulations comprising the extract.
A circuit structure and a method for supressing single event transients (SETs) or glitches in digital electronic circuits are provided. The circuit includes a first input which receives an output of a digital electronic circuit and a second input which receives a redundant or duplicated output of the digital electronic circuit. The circuit includes only four two-input gates of two different kinds selected from AND, OR, NAND and NOR gates. The four two-input gates being arranged so that a final circuit output is impervious to a change in a logic level of only the first input or only the second input, and the final circuit output is equivalent to the logic level of the first and second inputs when the logic level of the first and second inputs match.
Microalgae cultivation equipment for the cultivation of microalgae is provided in which a raceway is modified so as to contain multiple generally upright photobioreactor columns spaced apart along its length so as to increase the total surface area of liquid growth medium directly exposed to light and to improve the transfer of CO2 from the gas-phase to the liquid-phase by providing adequate height inside the vertical photobioreactor columns. The lowermost ends of the photobioreactor columns are immersed inside the liquid growth medium in the raceway component and are fed with liquid growth medium by a circulation promoting facility circulating the liquid growth medium from the raceway through the photobioreactor columns to become discharged back into the raceway. Gas inlets provide CO2 containing gas bubbles passing upwards in each of the photobioreactor columns. One or more paddle wheels or jet pumps induce a flow of liquid growth medium within the raceway.
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