This invention relates to a tool holder apparatus, a method of working an object and a tool, particularly for single point diamond turning (SPOT). The tool holder apparatus typically comprises: a tool holder which comprises: a base; a tool support extending from the base; a seat for a tool provided on the tool support, wherein the tool is locatable in the seat, in use; a sensor arrangement configured to generate electrical measurement signals indicative of, or associated with, at least an applied force to the tool, in use; and a piezoelectric actuator arrangement comprising at least one piezoelectric actuator operatively connected to the tool support, wherein the at least one piezoelectric actuator is configured to displace the tool support, or at least a part thereof, in use, in response to receiving suitable electrical control signal/s thereby to maintain a desired applied force to the tool, in use.
G05B 19/404 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par des dispositions de commande pour la compensation, p. ex. pour le jeu, le dépassement, le décalage d'outil, l'usure d'outil, la température, les erreurs de construction de la machine, la charge, l'inertie
B23Q 15/18 - Compensation de la déformation de l'outil due à la température ou à l'effort
B23B 29/12 - Agencements particuliers des porte-outils
2.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF SULFONYLUREA COMPOUNDS
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
The invention provides a system for performing distraction osteogenesis of a hand or other anatomical extremity. The system includes a proximal bone fixture component configured to engage a proximal portion of a bone segment, and a movable distractor component which can be positioned distal of the proximal bone fixture component and which is configured to engage a region of the hand located distal of the bone portion engaged by the bone fixture component. Drive means are provided for applying a distraction force between the bone fixture component and the distractor component, and a control component is provided to control operation of the drive means automatically. The drive means can be operated in a continuous manner. A user interface module is provided and can be separated from the control component after the system's operating parameters have been set. The invention also provides a method of performing distraction osteogenesis automatically.
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/24 - Giravions complexes, c.-à-d. aéronefs utilisant en vol à la fois les caractéristiques de l'avion et celles du giravion avec pales du rotor fixes en vol de façon à agir comme surfaces de sustentation
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
This invention provides a flow synthesis process for producing sulfonylurea compounds of formula (1), including gliclazide, chlorpropamide and tolbutamide, and pharmaceutically acceptable salts thereof.
C07C 269/04 - Préparation de dérivés d'acide carbamique, c.-à-d. de composés contenant l'un des groupes l'atome d'azote ne faisant pas partie de groupes nitro ou nitroso à partir d'amines avec formation de groupes carbamate
C07C 303/40 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'amides d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfonamide
C07C 311/58 - Y étant un hétéro-atome soit X, soit Y, mais pas les deux, étant des atomes d'azote, p. ex. N-sulfonylurée ayant des atomes de soufre des groupes sulfonylurée liés à des atomes de carbone de cycles aromatiques à six chaînons ayant des atomes d'azote des groupes sulfonylurée liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
C07D 209/52 - Composés hétérocycliques contenant des cycles à cinq chaînons condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle condensés avec un carbocycle condensés avec un cycle autre qu'un cycle à six chaînons
7.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF SULFONYLUREA COMPOUNDS
This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.
C07C 303/40 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'amides d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfonamide
C07C 311/46 - Y étant un atome d'hydrogène ou de carbone
C07C 311/59 - Y étant un hétéro-atome soit X, soit Y, mais pas les deux, étant des atomes d'azote, p. ex. N-sulfonylurée ayant des atomes de soufre des groupes sulfonylurée liés à des atomes de carbone de cycles aromatiques à six chaînons ayant des atomes d'azote des groupes sulfonylurée liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons
C07D 241/24 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
8.
SYSTEM AND METHOD FOR PERFORMING DISTRACTION OSTEOGENESIS
The invention provides a system for performing distraction osteogenesis of a hand or other anatomical extremity. The system includes a proximal bone fixture component configured to engage a proximal portion of a bone segment, and a movable distractor component which can be positioned distal of the proximal bone fixture component and which is configured to engage a region of the hand located distal of the bone portion engaged by the bone fixture component. Drive means are provided for applying a distraction force between the bone fixture component and the distractor component, and a control component is provided to control operation of the drive means automatically. The drive means can be operated in a continuous manner. A user interface module is provided and can be separated from the control component after the system's operating parameters have been set. The invention also provides a method of performing distraction osteogenesis automatically.
A device and method are provided for peening a surface. The peening device comprises a rotatable member, a flexible line that extends from the rotatable member and a peening element that is provided on the flexible line. In use, the line and peening element are rotated about the rotatable member such that when the peening element comes into contact with the surface, the surface is peened as result of kinetic energy of the peening element.
B24B 39/02 - Machines ou dispositifs à brunir, c.-à-d. utilisant des organes de pression pour durcir les surfacesAccessoires à cet effet pour travailler intérieurement des surfaces de révolution
B24B 39/00 - Machines ou dispositifs à brunir, c.-à-d. utilisant des organes de pression pour durcir les surfacesAccessoires à cet effet
10.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF OSELTAMIVIR
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
C07C 231/14 - Préparation d'amides d'acides carboxyliques par formation de groupes carboxamide combinée avec des réactions n'impliquant pas les groupes carboxamide
11.
CANNABINOID COMBINATIONS AND THEIR USE IN THE TREATMENT OF CANCER
A combination of cannabinoids, and a pharmaceutical composition comprising the combination, for use in the treatment of cancer is provided. In one embodiment the invention relates to a synergistic combination of cannabinoids (THC:CBG:CBN:CBD), a pharmaceutical composition comprising the combination, and the use of the combination or pharmaceutical composition in the treatment of cancer, in particular breast cancer.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/28 - Giravions complexes, c.-à-d. aéronefs utilisant en vol à la fois les caractéristiques de l'avion et celles du giravion avec hélices propulsives de déplacement pouvant pivoter pour agir comme rotors de sustentation
B64C 29/00 - Aéronefs capables d'atterrir ou de décoller à la verticale, p. ex. aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
B64C 39/02 - Aéronefs non prévus ailleurs caractérisés par un emploi spécial
B64D 27/02 - Aéronefs caractérisés par le type ou la position des groupes moteurs
B64D 29/04 - Nacelles, carénages ou capotages des groupes moteurs montés dans le fuselage
13.
A VERTICAL TAKE-OFF AND LANDING AIRCRAFT, METHODS AND SYSTEMS FOR CONTROLLING A VERTICAL TAKE-OFF AND LANDING AIRCRAFT
This invention relates to a vertical take-off and landing (VTOL) aircraft, a method of controlling a VTOL aircraft, and a control system for controlling the VTOL aircraft. The aircraft comprises an airframe having a wing extending along a transverse axis and attached to a fuselage extending between a longitudinal axis of the aircraft, and an empennage or canard. An array of electric rotors is fixedly mounted to the airframe. Front and rear internal combustion engines are pivotably mounted to the fuselage and are displaceable between lift positions in which the front and rear rotors are oriented to provide vertical lift to the aircraft for vertical flight and propulsion positions in which the front and rear rotors are oriented to provide forward thrust to the aircraft for horizontal flight. The front and rear rotors provide a majority, or all, of the vertical lift to the aircraft during vertical flight.
B64C 27/28 - Giravions complexes, c.-à-d. aéronefs utilisant en vol à la fois les caractéristiques de l'avion et celles du giravion avec hélices propulsives de déplacement pouvant pivoter pour agir comme rotors de sustentation
B64C 29/00 - Aéronefs capables d'atterrir ou de décoller à la verticale, p. ex. aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
B64D 27/24 - Aéronefs caractérisés par le type ou la position des groupes moteurs utilisant la vapeur ou l'énergie de ressorts
B64D 29/04 - Nacelles, carénages ou capotages des groupes moteurs montés dans le fuselage
B64D 27/02 - Aéronefs caractérisés par le type ou la position des groupes moteurs
B64C 39/02 - Aéronefs non prévus ailleurs caractérisés par un emploi spécial
14.
A CONTINUOUS FLOW SYNTHESIS METHOD FOR THE MANUFACTURE OF ISONIAZID
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.
A device and method are provided for peening a surface. The peening device comprises a rotatable member, a flexible line that extends from the rotatable member and a peening element that is provided on the flexible line. In use, the line and peening element are rotated about the rotatable member such that when the peening element comes into contact with the surface, the surface is peened as result of kinetic energy of the peening element.
B23P 9/04 - Traitement ou finition par martelage ou par pression répétée
B24B 39/00 - Machines ou dispositifs à brunir, c.-à-d. utilisant des organes de pression pour durcir les surfacesAccessoires à cet effet
C21D 7/06 - Modification des propriétés physiques du fer ou de l'acier par déformation par travail à froid de la surface par grenaillage ou similaire
C21D 8/02 - Modification des propriétés physiques par déformation en combinaison avec, ou suivie par, un traitement thermique pendant la fabrication de produits plats ou de bandes
17.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF OSELTAMIVIR
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
C07C 233/52 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons
18.
FLOW SYNTHESIS PROCESS FOR THE PRODUCTION OF OSELTAMIVIR
This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
C07C 233/52 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons
2 containing gas bubbles passing upwards in each of the photobioreactor columns. One or more paddle wheels or jet pumps induce a flow of liquid growth medium within the raceway.
The present invention provides for an extract that is produced from pomace obtained from an Olea europaea fruit oil production process. The extract comprises a mixture of oil-soluble and water-soluble compounds including hydroxytyrosol, tyrosol, oleuropein, αtocopherol, and squalene. The invention further provides for a method of producing the extract, and formulations comprising the extract.
A circuit structure and a method for supressing single event transients (SETs) or glitches in digital electronic circuits are provided. The circuit includes a first input which receives an output of a digital electronic circuit and a second input which receives a redundant or duplicated output of the digital electronic circuit. The circuit includes only four two-input gates of two different kinds selected from AND, OR, NAND and NOR gates. The four two-input gates being arranged so that a final circuit output is impervious to a change in a logic level of only the first input or only the second input, and the final circuit output is equivalent to the logic level of the first and second inputs when the logic level of the first and second inputs match.
Microalgae cultivation equipment for the cultivation of microalgae is provided in which a raceway is modified so as to contain multiple generally upright photobioreactor columns spaced apart along its length so as to increase the total surface area of liquid growth medium directly exposed to light and to improve the transfer of CO2 from the gas-phase to the liquid-phase by providing adequate height inside the vertical photobioreactor columns. The lowermost ends of the photobioreactor columns are immersed inside the liquid growth medium in the raceway component and are fed with liquid growth medium by a circulation promoting facility circulating the liquid growth medium from the raceway through the photobioreactor columns to become discharged back into the raceway. Gas inlets provide CO2 containing gas bubbles passing upwards in each of the photobioreactor columns. One or more paddle wheels or jet pumps induce a flow of liquid growth medium within the raceway.
brevets
