Abstract

Provided is a viral vector delivery system for the porcine respiratory tract and digestive tract. The viral vector delivery system comprises a backbone plasmid obtained by inserting full-length cDNA of porcine enterovirus type B into a pUC57 plasmid, and a helper plasmid obtained by inserting a green fluorescent protein-encoding gene into plasmid pCAG-T7-polymerase. The virus titer of the viral vector delivery system can reach 107.755050 per mL, and porcine respiratory tract and digestive tract pathogenic epitopes are inserted into the backbone plasmid, which has a good immune effect and can be used for constructing candidate strains of porcine respiratory tract and digestive tract vaccines.

IPC Classes  ?

• C12N 15/8 -
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
• C12N 15/65 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression using markers
• A61K 39/12 - Viral antigens
• A61K 39/02 - Bacterial antigens
• A61P 31/20 - Antivirals for DNA viruses
• A61P 31/04 - Antibacterial agents

Abstract

Embodiments disclosed herein relate to an autonomous work excavator and an operation method therefor. According to an embodiment, an autonomous work excavator comprises: a front work device including an arm, a boom, and a bucket; a sensor device configured to collect state information about the excavator and information relating to the surrounding environment; and a processor electrically connected to the front work device and the sensor device. The processor can control so as to: conduct an excavation operation on the basis of work instructions so that earth and sand are loaded in the bucket; calculate the zero moment point (ZMP) of the force acting on the excavator on the basis of mass information about at least a portion of the front work device after the excavation operation; and acquire a work trajectory for processing the earth and sand loaded in the bucket by using the information relating to the ZMP and the surrounding environment.

IPC Classes  ?

• E02F 9/20 - DrivesControl devices
• E02F 9/24 - Safety devices

Abstract

The present invention relates to a plasma actuator for flow control and, more specifically, to a plasma actuator for flow control, the actuator generating plasma so as to control surrounding flow. The plasma actuator for flow control, of the present invention, can actively and effectively control the generation of plasma according to changes in the surrounding flow environment while using relatively little electric power.

IPC Classes  ?

• H05H 1/24 - Generating plasma

Abstract

Provided is a credit-based multipath data transmission method for load balancing of a data center network, the method comprising the steps of: transmitting a credit request packet to a receiver device; in response to the credit request packet, determining at least one first path along which credit packets can be received earliest from the receiver device, among all the communicable paths to the receiver device; each time that a credit packet is received through the first path from the receiver device, transmitting a data packet to the receiver device through the first path in response to the credit packet, wherein the credit packets received through the first path are in one-to-one correspondence with the data packets transmitted to the receiver device through the first path; and when there are no more data packets left to transmit to the receiver device, transmitting a credit stop packet to the receiver device.

IPC Classes  ?

• H04L 12/707 - Route fault prevention or recovery, e.g. rerouting, route redundancy, virtual router redundancy protocol [VRRP] or hot standby router protocol [HSRP] using path redundancy
• H04L 12/753 - Routing tree discovery, e.g. converting from mesh topology to tree topology
• H04L 12/803 - Load balancing, e.g. traffic distribution over multiple links
• H04L 12/841 - Flow control actions using time consideration, e.g. round trip time [RTT]
• H04L 12/801 - Flow control or congestion control

Abstract

The present invention relates to a centrifugal pump impeller having a serration structure applied thereto, and more specifically, to a centrifugal pump impeller having a serration structure applied thereto, the impeller having a structure enabling the reduction of a vortex generated at the end of an impeller blade, thereby enabling the efficiency of a centrifugal pump to be increased. The centrifugal pump impeller having a serration structure applied thereto, according to the present invention, has a serration structure applied to an impeller blade of a centrifugal pump, and thus has an effect whereby a vortex generated at the impeller blade is reduced, and thus noise and vibration of the centrifugal pump are suppressed, and the efficiency of the centrifugal pump is increased.

IPC Classes  ?

• F04D 29/24 - Vanes
• F04D 29/22 - Rotors specially for centrifugal pumps
• F04D 29/66 - Combating cavitation, whirls, noise, vibration, or the likeBalancing

Abstract

The present invention relates to a cross-flow fan and housing, and more specifically, to a cross-flow fan and housing having a structure enabling the reduction of a flow separation phenomenon occurring at the cross-flow fan and housing, thereby enabling increased energy efficiency. The cross-flow fan and housing, according to the present invention, has an effect whereby a flow separation phenomenon occurring at the cross-flow fan and housing is reduced, and thus noise and vibration of a fluid machine are suppressed, and the efficiency of the fluid machine is increased.

IPC Classes  ?

• F04D 29/42 - CasingsConnections for working fluid for radial or helico-centrifugal pumps
• F04D 29/46 - Fluid-guiding means, e.g. diffusers adjustable
• F04D 29/30 - Vanes
• F04D 29/28 - Rotors specially adapted for elastic fluids for centrifugal or helico-centrifugal pumps

Abstract

The present invention relates to a method for preparing fuel cell catalyst iron phosphide nanoparticles, and fuel cell catalyst iron phosphide nanoparticles prepared thereby. More specifically, provided is a method for preparing fuel cell catalyst iron phosphide nanoparticles, the method coating carbon on the surface of the iron phosphide nanoparticles in order to improve the activity and durability of the iron phosphide nanoparticles to be used as a fuel cell catalyst. Therefore, the present invention can coat carbon on the surface of iron phosphide nanoparticles while preparing the iron phosphide nanoparticles with a single heat treatment process, and can improve the durability of the iron phosphide nanoparticles by physically and chemically protecting the iron phosphide nanoparticles through the carbon coated on the surface of the iron phosphide nanoparticles.

IPC Classes  ?

• H01M 4/90 - Selection of catalytic material

Abstract

The present invention relates to a S1PR4-targeting composition for preventing or treating non-alcoholic steatohepatitis and, more particularly, to a pharmaceutical composition and a health functional food composition, both comprising a sphingolipid compound which serves as a functional inhibitor against S1PR4, showing prophylaxis and therapy of non-alcoholic steatohepatitis. The sphingolipid compound of the present invention is expected to be applied as a leading material effective for the prevention or treatment of non-alcoholic steatohepatitis (NASH) as it has the effect of reducing the infiltration of inflammatory cells into hepatic tissues and suppressing fibrosis and decreases a level of liver injury (ALT), inflammation in hepatic tissues, and the expression of a fibrosis-related gene.

IPC Classes  ?

• A61K 31/42 - Oxazoles
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/66 - Phosphorus compounds
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a S1PR4-targeting composition for preventing or treating non-alcoholic steatohepatitis and, more particularly, to a pharmaceutical composition and a health functional food composition, both comprising a sphingolipid compound which serves as a functional inhibitor against S1PR4, showing prophylaxis and therapy of non-alcoholic steatohepatitis. The sphingolipid compound of the present invention is expected to be applied as a leading material effective for the prevention or treatment of non-alcoholic steatohepatitis (NASH) as it has the effect of reducing the infiltration of inflammatory cells into hepatic tissues and suppressing fibrosis and decreases a level of liver injury (ALT), inflammation in hepatic tissues, and the expression of a fibrosis-related gene.

IPC Classes  ?

• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/42 - Oxazoles
• A61K 31/66 - Phosphorus compounds

Abstract

Provided in the present invention is a nucleic acid extraction apparatus comprising: a first container, which includes a nanofilter having uniform nano-sized pores and provided on the lower surface thereof, can support a first liquid, and has one or more first wells comprising a first electrode immersible in the first liquid; and a second container, which can accommodate the first well, can support a second liquid, and has one or more second wells comprising a second electrode immersible in the second liquid.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The present invention relates to a marking material having a contrasting effect and tissue adhesion characteristics and comprising core/shell nanoparticles, which are structured to comprise a core having a contrasting effect and a silica shell formed on the surface of the core, and a method for manufacturing the same. More particularly, the present invention relates to core/shell nanoparticles configured such that the core portion has a contrasting effect, and the silica shell portion has tissue adhesion characteristics, thereby giving the core/shell nanoparticles both the tissue adhesion characteristics and the contrasting effect. Therefore, according to the present invention, the nanoparticles can be utilized as a tissue adhesive and as a contrast medium, and can be used as a marking material for a real-time multi-mode image-based technology.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The present invention relates to a recombinant antigen protein composed of multiple epitopes in order to develop a foot-and-mouth disease subunit vaccine and a method for producing the same. A recombinant expression vector according to the present invention can mass-produce recombinant antigen proteins inexpensively and safely through microorganism culture and can be easily purified. It is confirmed that the recombinant antigen protein produced by the recombinant expression vector is composed as a multi-epitope to improve immune responses against various foot-and-mouth disease variants. Therefore, the recombinant expression vector can be advantageously used as a tool for providing a recombinant antigen protein that can be used as an effective foot-and-mouth disease subunit vaccine.

IPC Classes  ?

• A61K 39/135 - Foot-and-mouth disease virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a centrifugal pump impeller including a ridge structure and, more specifically, to a centrifugal pump impeller including a ridge structure, which is capable of improving the efficiency of a centrifugal pump. The centrifugal pump impeller including the ridge structure, of the present invention, applies the ridge structure to impeller blades of the centrifugal pump, thereby having advantageous effects of minimizing the occurrence of flow separation inside the impeller and improving the efficiency of the centrifugal pump.

IPC Classes  ?

• F04D 29/24 - Vanes
• F04D 29/30 - Vanes
• F04D 29/66 - Combating cavitation, whirls, noise, vibration, or the likeBalancing

Abstract

The graphene flake thin film manufacturing apparatus according to the present invention, which produces graphene on a substrate by using graphite powder, comprises: a substrate disposition unit having a substrate disposed at one side thereof; a nozzle unit which is in a tubular shape having an interior space so as to allow for the movement of graphite powder, has a spray hole at one side thereof, and sprays the graphite powder onto the substrate through the spray hole; and a graphite supply unit communicating with the interior space of the nozzle unit and supplying the graphite powder to the interior space. The graphene flake thin film manufacturing apparatus and graphene flake thin film manufacturing method, according to the present invention, are configured such that graphene flake thin films can be manufactured by depositing graphene on substrates by spraying graphite powder via the nozzle unit so as for same to collide with the substrates at a high speed.

IPC Classes  ?

• C01B 32/182 - Graphene
• C04B 35/52 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbon, e.g. graphite
• C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
• C04B 41/85 - Coating or impregnating with inorganic materials
• C23C 24/04 - Impact or kinetic deposition of particles

Abstract

The present invention relates to a drug delivery system for effectively administering a drug into human (or animal) body tissue. The microjet drug delivery system provided by the present invention comprises: (a) a microjet injector comprising: a pressure chamber sealed at a part of a side surface thereof by an elastic membrane and hermetically filled with a pressure generating liquid; and a drug chamber disposed adjacent to the pressure chamber with the elastic membrane therebetween, containing a drug solution therein, and having a micro-nozzle formed at one side thereof, the micro-nozzle being provided to discharge the drug solution to the outside therethrough; (b) a laser generator, configured to generate a laser beam and emit the laser beam to the outside, for irradiating a laser beam onto the pressure generating liquid in the microjet injector to generate bubbles; and (c) a fractional laser filter module for dividing the beam incident from the laser generator into a plurality of fractional laser beams, each reduced in diameter, and for outputting the fractional laser beams. The microjet drug delivery system of the present invention as described above selectively removes the stratum corneum through a process of pre-ablating skin in advance using a fractional laser beam, and performs drug microjet injection at a site which is relatively weakened due to the removal of the stratum corneum, thereby effectively infiltrating a drug into skin tissue.

IPC Classes  ?

• A61M 5/30 - Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or cartridges
• A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
• A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
• H01S 3/16 - Solid materials
• G02B 27/14 - Beam splitting or combining systems operating by reflection only

Abstract

The present invention relates to a blood pump. The blood pump according to the present invention comprises: a housing having an inlet, through which blood flows, provided at an upper part thereof and an outlet, through which the blood is discharged, provided along an edge thereof; an impeller part rotatably provided inside the housing, and having a plurality of blades provided on the surface thereof so as to move, toward the outlet by centrifugal force, the blood flowing in through the inlet; a rotary shaft member provided to pass through a center portion of the impeller part so as to support the impeller part to be rotatable, and moving the blood to a lower part thereof; and a magnetic body provided at the impeller part so as to rotate the impeller part in a predetermined direction according to a change in a magnetic field outside the housing.

IPC Classes  ?

• A61M 1/10 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
• A61M 1/12 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps implantable into the body

Abstract

The present invention relates to a bending sensor and, more specifically, to a bending sensor for measuring the bending angle of a joint in a configuration such as the joint of a robot. The bending sensor of the present invention has an effect of providing a bending sensor which has a simple structure, and thus can be manufactured at low cost, has high linearity, and can effectively measure the bending angle of an object even at a high curvature.

IPC Classes  ?

• G01B 5/30 - Measuring arrangements characterised by the use of mechanical techniques for measuring the deformation in a solid, e.g. mechanical strain gauge
• G01B 5/24 - Measuring arrangements characterised by the use of mechanical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of mechanical techniques for testing the alignment of axes
• G01D 11/18 - Springs
• G01D 11/06 - Strip or thread suspensions, e.g. in tension

Abstract

The present invention provides a rabbit monoclonal antibody to acetylated mouse BubR1 and a preparation method therefor and, more particularly, provides the use of the monoclonal antibody in a method for measuring the activity of cell division checkpoints on the basis of a degree of acetylation of BubR1, a method for detecting a tumor disease on the basis of aberrant cell division, a method for diagnosing cancer, a method for screening anti-cancer agents, or a method for regulating a cell division cycle.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a composition for regulating cell division by promoting or inhibiting the activity of FCHo1, and a method for regulating cell division using the same. The FCHo1 activity modulator of the present invention targets FCHo1 which functions as an important factor in cell division, and promotes or inhibits the activity thereof, thereby promoting cell division or inhibiting cell division, and thus can be effectively utilized for the treatment of diseases associated with cell division.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention is to provide an underwater moving apparatus with an enhanced maneuvering performance. The underwater moving apparatus with an enhanced maneuvering performance, according to the present invention, comprises: a moving apparatus body having a propeller; a plurality of long grooves formed on an outer surface of the moving apparatus body in the longitudinal direction of the moving apparatus body; a plurality of ridges which are movably installed in the inner and outer directions by being disposed on the long grooves of the moving apparatus body in the longitudinal direction of the moving apparatus body so as to protrude from the outer surface of the moving apparatus body; a ridge driving device installed in the moving apparatus body to move the plurality of ridges so as to protrude from the outer surface of the moving apparatus body; and a controller which controls the ridge driving device to prevent flow separation in the moving apparatus body by forming an eddy flow on the outer surface of the moving apparatus body in such a manner that the ridges protrude from the outer surface of the moving apparatus body when the angle of attack of the moving apparatus body becomes greater than a certain angle during underwater movement of the moving apparatus body.

IPC Classes  ?

• B63G 8/00 - Underwater vessels, e.g. submarines
• B63G 8/14 - Control of attitude or depth
• F42B 19/01 - Steering control

Abstract

The present invention relates to a substrate treatment apparatus. The substrate treatment apparatus according to the present invention comprises: a chamber providing a space for treating a substrate; a support unit, provided inside the chamber, for supporting the substrate; and a nozzle for providing a cleaning medium to the substrate supported by the support unit, wherein the nozzle comprises: a contracting portion having an inlet through which the cleaning medium flows in, and having a cross-sectional area which decreases as the distance from the inlet increases; an expanding portion having a spray opening through which the cleaning medium is sprayed, and having a cross-sectional area which increases as the distance to the spray opening decreases; and an orifice located between the contracting portion and expanding portion, wherein the cleaning medium flowing into the contracting portion is a single gas.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
• H01L 21/683 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for supporting or gripping

Abstract

The present invention provides RAPGEF2, IFT80, SSH2, XRCC3, SPAG17, PLEKHM2, CLEC4C, FRAS1, ADGRL3, and PSEN1 mutant genes and mutant proteins as markers for amyotrophic lateral sclerosis and a diagnostic method for amyotrophic lateral sclerosis using the same. The markers for amyotrophic lateral sclerosis of the present invention, which are new variants found in Korean ALS patients, are very rare variants with a frequency of less than 0.1% in the previously reported database or variants that have not been reported, and are variants not found in normal control groups. The mutant genes and/or the mutant proteins encoded therefrom found in the present invention can be very favorably used in establishing genetic causes of ALS and diagnosing ALS. A gene or protein test is performed on the mutant genes and/or the mutant proteins encoded therefrom found in the present invention, thereby allowing early diagnosis of amyotrophic lateral sclerosis and maximizing the therapeutic effect through the early application of an appropriate treatment method, and furthermore, enabling accurate customized treatment according to the etiological cause.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a technique for suppressing membrane biofouling on the surface of a separation membrane by immobilizing biofilm formation-suppressing microorganisms and using the same in a microorganism immobilizing container during a separation membrane water treatment process, and provides a biofilm formation-suppressing microorganism immobilizing container comprising: a non-hollow/hollow pillar-type or sheet-type transmissive carrier having mobility because of submerged aeration; and biofilm formation-suppressing microorganisms immobilized inside the carrier. In addition, the present invention provides a separation membrane water treatment device comprising: a reactor for accommodating treated water; a separation membrane module for water treatment; and the biofilm formation-suppressing microorganism immobilizing container arranged inside the reactor.

IPC Classes  ?

• C02F 3/10 - PackingsFillingsGrids
• C02F 3/08 - Aerobic processes using moving contact bodies
• C02F 3/12 - Activated sludge processes
• B01D 65/02 - Membrane cleaning or sterilisation
• B01D 65/08 - Prevention of membrane fouling or of concentration polarisation
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

The present invention relates to a system for measuring the rotational cycle of a rotor and, more particularly, to a system for measuring the rotational cycle of a rotor, for accurately measuring the cycle and rotational phase angle of the rotor in order to evaluate measurement values of the flow field of the rotor. The system for measuring the rotational cycle of a rotor according to the present invention has an effect of allowing the rotational cycle and rotational phase of a rotor to be accurately determined regardless of the blade structure of the rotor, thereby effectively evaluating the flow field measurement data of the rotor.

IPC Classes  ?

• G01D 5/34 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells
• G01V 8/14 - Detecting, e.g. by using light barriers using one transmitter and one receiver using reflectors

Abstract

A bio-sensor for detecting a specific target, according to the present embodiment, comprises: a substrate; a first electrode and a second electrode, which are arranged on the substrate so as not to be electrically connected to each other; and a probe which is arranged on the substrate, the first electrode, and the second electrode, and couples with a target.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present invention relates a catalyst for water splitting and a method for preparing the same and, more specifically, to a catalyst for water splitting composed of: at least one transition metal selected from the group consisting of Mn, Fe, Co, Ni, an Cu; and a silicon-containing oxide or hydroxide, the catalyst being amorphous, and to a method for preparing a catalyst for water splitting.

IPC Classes  ?

• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• B01J 23/34 - Manganese
• B01J 23/70 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper
• B01J 37/03 - PrecipitationCo-precipitation

Abstract

The present invention relates to a resource circulation type restroom and, specifically, to a restroom separating feces and urine, storing the same, and then composting the same. The present invention comprises: a toilet having a bowl; a conveyor provided at the lower end of the toilet; a liquid fertilizer producing tank for producing liquid fertilizer from the urine transferred by the conveyor; and a conveyor washing device for spraying the urine, which was changed into the liquid fertilizer in the liquid fertilizer producing tank, at a moving means including the toilet and/or the conveyor. Therefore, the present invention separates feces and urine, composts the feces between the separated feces and urine, and produces the liquid fertilizer from the urine, thereby recycling the feces and urine. In addition, the present invention does not use water since the urine is changed into the liquid fertilizer, and then the liquid fertilizer is used to wash the moving means. Furthermore, the present invention can effectively separate the feces and the urine through the conveyor. Moreover, the present invention can increase the efficiency of producing the liquid fertilizer from the urine since a partition is provided in the liquid fertilizer producing tank such that the urine moves by flowing over the partition.

IPC Classes  ?

• A47K 11/02 - Dry closets, e.g. incinerator closets
• C05F 3/06 - Apparatus for their manufacture
• C05F 3/04 - Fertilisers from human or animal excrements, e.g. manure from human faecal masses

Abstract

The present invention provides a Pvr4 gene having resistance to potyvirus and a use thereof. The present invention can contribute to the breeding of potyvirus-resistant chili peppers by using a molecular marker using a Pvr4 gene sequence. In addition, the present invention can transform potatoes or tomatoes, as heterogeneous crops, showing, economically, an enormous reduction in production due to potyvirus, and an increased crop yield and an economical effect can be expected through such a transformation.

IPC Classes  ?

• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
• C07K 16/16 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from plants
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

An image information collecting system comprises: a position transmitting device for transmitting first position information indicating a position of the image information collecting system itself; a plurality of cameras for collecting image data, storing the image data in a storage medium of the image information collecting system itself, generating data identification information including oriented direction information of a camera and time information at a time point at which the image data has been collected, and transmitting the data identification information through a network; and a service server for receiving the first position information and the data identification information, and determining whether a target camera for photographing a current position of the position transmitting device exists among the plurality of cameras, using the data identification information and second position information indicating positions of the plurality of cameras.

IPC Classes  ?

• G08B 13/196 - Actuation by interference with heat, light, or radiation of shorter wavelengthActuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras

Abstract

Disclosed are: a method for controlling the resistance of a plant to environmental stress, comprising a step of transforming plant cells with a recombinant vector including a gene coding for a rice-derived Oryza sativa Aux/IAA 6 (OsIAA6) protein; a method for producing a transgenic plant body of which the resistance of a plant to environmental stress is controlled, comprising a step of transforming plant cells with the recombinant vector including a gene coding for the OsIAA6 protein; a transgenic plant body produced by the method and of which the resistance to environmental stress is controlled; and seeds thereof.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy

Abstract

The present invention relates to a portable toilet and, specifically, to a portable toilet combined with an excrement separation device. The present invention facilitates transportation since a body thereof has a box shape but is folded prior to assembly. In addition, the present invention can prevent feces inside the body from being seen by forming an inclined plane inside the body. Moreover, the present invention comprises an area separation bar inside the body and allows an excrement bag to be hung over the area separation bar, thereby allowing excrement to be stored in a separated manner rather than allowing excrement to be stored in a combined manner in the excrement bag. Furthermore, the present invention comprises, in advance, a solidifying agent in the urine storage area of the excrement bag, thereby enabling urine to be received several times in one excrement bag.

IPC Classes  ?

• A47K 11/02 - Dry closets, e.g. incinerator closets

Abstract

The present invention relates to graphene and, particularly, to a method for doping graphene using substrate surface modification, a method for manufacturing a graphene composite electrode using graphene and inorganic matter, and a graphene structure comprising the same. The method for doping graphene according to an embodiment of the present invention may comprise the steps of: forming, on a substrate, a precursor polymer layer for doping; and positioning graphene on the substrate on which the precursor polymer layer is formed. In addition, the method for manufacturing a graphene composite electrode according to an embodiment of the present invention may comprise the steps of: forming graphene on catalyst metal; forming a transparent conductive oxide on the graphene; crystallizing the transparent conductive oxide by applying heat of 150 °C or higher; and transferring, to a final substrate, a composite electrode consisting of the graphene and the transparent conductive oxide.

IPC Classes  ?

• C01B 31/04 - Graphite
• C23C 16/26 - Deposition of carbon only
• H01L 21/283 - Deposition of conductive or insulating materials for electrodes
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

The present invention relates to a rainwater collecting facility and a moving-type rainwater storage tank and a system for moving rainwater on water, and especially, to a rainwater collecting facility and a moving-type rainwater storage tank and a system for moving rainwater on water enabling rainwater to be collected by the rainwater collecting facility, transferred on water, and then used in a place of use by floating same on water.

IPC Classes  ?

• E03B 3/02 - Methods or installations for obtaining or collecting drinking water or tap water from rain-water

Abstract

The present invention relates to a transformable transport device and a joint module provided therein, the transformable transport device comprising: a main frame having opposite ends that are in communication with each other; a guide frame that has a specified length such that the main frame is mounted thereon, wherein the main frame moves to a specified position on the guide frame and is fixed to the specified position; a joint module detachably coupled to the main frame such that the angle of the joint module relative to the main frame is adjusted; a plurality of front-side units, each of which includes a front-side wheel and is selectively detachably coupled to one end portion of the guide frame; and rear-side units selectively detachably coupled to opposite end portions of the joint module so as to be rotatable, each rear-side unit comprising one or more rear-side wheels. As such, the transformable transport device can implement a plurality of transport means, which can be used from infancy to adolescence, with a single device.

IPC Classes  ?

• B62K 13/00 - Cycles convertible to, or transformable into, other types of cycles or land vehicles
• B62K 17/00 - Cycles not otherwise provided for
• B62B 7/12 - Carriages for childrenPerambulators, e.g. dolls' perambulators having more than one wheel axisSteering devices therefor convertible, e.g. into children's furniture or toy
• B62K 9/02 - Tricycles

Abstract

The present invention relates to biodegradable magnesium and a method for preparing the same. The biodegradable magnesium according to the present invention is characterized in that the biodegradation rate of the biodegradable magnesium is controlled using a difference in atom packaging density.

IPC Classes  ?

• A61L 27/04 - Metals or alloys

Abstract

A sound data processing system according to the present embodiment is a system comprising a plurality of sound collecting terminals, a plurality of sound providing terminals, and a server, each sound collecting terminal and sound providing terminal, from among the plurality of sound collecting terminals and sound providing terminals, comprising: a sound collecting means for collecting sounds with location and orientation direction; a sound providing means for providing sounds with location and orientation direction; a location detection means for detecting the location of the sound collecting means and sound providing means; a direction detection means for detecting a orientation direction; supplementary data comprising location data corresponding to the location detected by the location detection means, and orientation direction data corresponding to the orientation direction detected by the direction detection means; and a communication module for transmitting, via the network, sound data corresponding to the sound collected by the sound collection means.

IPC Classes  ?

• H04R 3/00 - Circuits for transducers
• H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers

Abstract

Disclosed are T-ALT 1 and 2 elements acting on an alternative-lengthening-of-telomeres mechanism, and a use thereof. According to the present application, the elements can be used as a marker for detecting intracellular ALT activity or can be useful for screening for a material, and the like, for a cancer therapeutic agent.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present invention provides a hierarchical microstructure having a novel structure, and a manufacturing method for a mold for manufacturing the same. A mold for forming a hierarchical microstructure, manufactured by the manufacturing method, can form a microstructure having various hierarchical structures, for example, a micro/nano dual structure and a base/bridge dual structure, using a simple process, and can form a microstructure up to the bottom surface of each layer, thereby forming a hierarchical microstructure having a larger specific surface area. The present invention can be applied to various fields, such as surface treatment of a large moving means, a functional material having ultra hydrophobicity, an industrial robot, and an electronic element, in which such a microstructure having a multiscale is used.

IPC Classes  ?

• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

One embodiment provides a technique of adjusting a gate voltage to be applied to at least one MOS capacitor and an amount of electric charges to be stored in the MOS capacitor so as to determine sensitivity of a change in the amount of electric charges stored in the MOS capacitor, and exposing the MOS capacitor to an electric filed for a predetermined amount of time and then reading an electron inflow or outflow result due to the electric field so as to interpret the intensity and the direction of the electric field, thereby measuring the intensity and the direction of the electric field.

IPC Classes  ?

• G01R 29/12 - Measuring electrostatic fields
• G01R 29/08 - Measuring electromagnetic field characteristics

Abstract

The present invention relates to a new biomarker and, more particularly, to a sorafenib reactive prediction kit for a liver cancer patient, the kit containing, as an effective ingredient, a probe molecule which can detect EDN1 protein within a sample or the level of mRNA encoding the EDN1 protein.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention presents a novel prediction model for calculating a periodontal disease prediction score and provides a system and a method therefor. Unlike conventional technology, the prediction model is obtained by taking into consideration all of social and economic habit factors, molecular and biological factors and whole-body health factors, and a verification result diagnosis ability thereof has been confirmed to be excellent.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

A system for collecting event data comprises: a plurality of cameras, each of which collects image data and stores the image data on a storage medium, generates data identification information including at least one information from among the group including time information on when the image data was collected, location information on where the image data was collected, and orientation information of a camera, and transmits periodically, or at a specific point of time, the data identification information via a wired or wireless network; and a service server which determines, among the plurality of cameras, at least one target camera storing image data related to a specific event by using the data identification information and event information including the time and location when and where the event occurred, and receives image data related to the event from the target camera.

IPC Classes  ?

• G06Q 50/10 - Services
• G08B 13/196 - Actuation by interference with heat, light, or radiation of shorter wavelengthActuation by intruding sources of heat, light, or radiation of shorter wavelength using passive radiation detection systems using image scanning and comparing systems using television cameras

Abstract

The present invention relates to a method and an apparatus for estimating multiple-ranking using pairwise comparative data, the method according to one embodiment comprising the steps of: inputting information for pairwise comparative data as input; and generating multiple-ranking data on the basis of the input data, wherein the input data comprises a collection of a plurality of respondents, a collection of a plurality of items, and a collection of a plurality of pairwise comparative data for the plurality of items, and each item of pairwise comparative data in the plurality of same is data indicating the preference between two items determined in accordance with an evaluation criterion from among a plurality of evaluation criteria.

IPC Classes  ?

• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Abstract

The present invention provides a technique of minimizing traffic and time required for restoring an original file in a file management apparatus for restoring an original file from a plurality of storage devices. The file management method of the present invention comprises the steps of: selecting, from among a plurality of storage devices, storage devices that will receive file fragments; determining scheduling information indicating the file fragments to be received from the selected storage devices according to the communication speed between the file management apparatus and the selected storage devices; receiving the file fragments from each of the selected storage devices by referencing the determined scheduling information; and generating a restored file from the received file fragments.

IPC Classes  ?

• G06F 11/08 - Error detection or correction by redundancy in data representation, e.g. by using checking codes

Abstract

The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper

Abstract

The present invention relates to a file distribution management apparatus and method for managing files so that predetermined file fragments are generated using a given file, and an initial file can be restored from a predetermined number of files or more but cannot be restored from less than a predetermined number of files among the file fragments. In addition, the present invention enhances security by shuffling the order of original files when the file fragments are generated. In a method for shuffling the order of the original files according to one embodiment of the present invention, the order of the original files is shuffled by a block unit, and the size of a block can be randomly selected by a user. Further, the file fragments are formed by generating a plurality of segments from the original files, and the sizes of the plurality of segments have a constant ratio or an arbitrary value.

IPC Classes  ?

• G06F 15/16 - Combinations of two or more digital computers each having at least an arithmetic unit, a program unit and a register, e.g. for a simultaneous processing of several programs

Abstract

The present invention relates to an organic compound used as an electron acceptor and a preparation method for same. An organic compound used as an electron acceptor, according to an embodiment of the present invention, is represented by the following chemical formula (1) (chemical formula (1)), wherein Ar1 is one of the structures shown in the following chemical formula (2) (chemical formula (2)) and Ar2 is one of the structures shown in the following chemical formula (3) (chemical formula (3)).

IPC Classes  ?

• C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation

Abstract

The present invention is for the purpose of installing a wireless transmitter in a transmitting unit of a bioelectric signal measuring device and changing electrodes to be attachable/detachable in order to: prevent the usable distance of the bioelectric signal measuring device from being restricted by limitations in the length of electric wire between a transmitter and a receiver, prevent the electric wire impeding an operation by blocking the field of vision during the operation, and reduce the danger of a disconnected electric wire. The present invention provides a bioelectric signal measuring device comprising: an insulation film capable of being attached to the outer peripheral surface of a bio catheter that is inserted into an opening of the human body; a plurality of thin film electrodes arranged to contact muscle or nerve regions at which a portion of the bio catheter is located; a transmitter for wirelessly transmitting a bioelectric signal scanned by the thin film electrodes; conductive wire electrically connecting the thin film electrodes to the transmitter; and a battery for operating the transmitter, wherein the electrodes, the transmitter, the conductive wire, and the battery are disposed on the insulation film. Also provided is a bioelectric signal measuring device configured of a head portion having a broad surface area and a tail portion connected to the head portion, the device comprising: an insulation film capable of being attached along the length of a bio catheter that is inserted into the human body; a plurality of thin film electrodes disposed on the head portion that is the opposite surface to the insulation film attached on the bio catheter, and arranged to contact muscle or nerve regions at which a portion of the bio catheter is located; and conductive wire located on the tail portion of the insulation film, and having one end electrically connected to the thin film electrodes and the other end connected to the terminal end of the tail portion.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/0488 - Electromyography
• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)

Abstract

The present invention relates to a novel pentadienoyl piperidine derivative, a pharmaceutical composition containing the same for preventing or treating a metabolic disease, and a functional food composition for alleviating or mitigating a metabolic disease using the same. The pentadienoyl piperidine derivative of the present invention inhibits the differentiation of preadipocytes, reduces body weight, visceral fat, blood lipid level, and blood sugar, improves a blood liver function index, and suppresses metabolic inflammation responses, and thus, ultimately, can be favorably used as a pharmaceutical composition or a functional food composition, which exhibits activity to prevent or treat a metabolic disease selected from the group consisting of obesity, diabetes, abnormal hypertriglyceridemia, fatty liver, and insulin resistance syndrome.

IPC Classes  ?

• C07D 211/32 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
• C07D 211/06 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61P 3/04 - AnorexiantsAntiobesity agents

Abstract

Disclosed are mesenchymal stem cells overexpressing Oct4 and Sox2 and a use thereof as a cell therapeutic agent. The mesenchymal stem cells overexpressing Oct4 and Sox2 according to the present invention have outstandingly improved proliferation ability and an ability to differentiate into fat cells, bone cells and hepatocytes, and particularly are used in the treatment of chronic liver diseases such as liver cirrhosis, so that liver functions damaged by liver diseases can be improved and a regeneration-promoting effect can be expected.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 35/407 - LiverHepatocytes

Abstract

A field-programmable analog array according to an embodiment of the present invention comprises an array of a plurality of programmable analog timing circuits, the field-programmable analog array being field-programmable to a plurality of analog or analog-to-digital conversion circuits, such as relaxation oscillators, phase shifters, phase interpolators, pulse width modulators, pseudo index digitally controlled oscillators, etc. through programming, without physical circuit re-processing. Further, a field-programmable mixed signal array according to an embodiment of the present invention comprises a plurality of field-programmable analog arrays, field-programmable digital blocks and field-programmable connecting wire blocks, the field-programmable mixed signal array being field-programmable to a plurality of analog, digital or analog-to-digital conversion circuits, such as digital pulse width modulators, time-digital converters, analog-digital converters, phase locked loops, DC-DC, AC-DC and DC-AC converters, etc. through programming, without physical circuit re-processing.

IPC Classes  ?

• H03K 19/177 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using elementary logic circuits as components arranged in matrix form

Abstract

The present invention relates to an adsorbent comprising silica nanoparticles with corrugated surfaces, and to a method for preparing the same, wherein the adsorbent can easily adsorb an adsorption material and can selectively adsorb a particular material.

IPC Classes  ?

• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/32 - Impregnating or coating
• C01B 33/12 - SilicaHydrates thereof, e.g. lepidoic silicic acid

Abstract

The present invention relates to a method for preparing titanium by using electrowinning and, more specifically, to a method for preparing titanium by using electrowinning, comprising the steps of: preparing a mixture by mixing a solid electrolyte, which contains an oxide of the group 1 elements and boron oxide, and titanium dioxide; and forming a molten oxide from the mixture by putting the mixture in an electrowinning apparatus comprising an anode and an insoluble cathode and heating the same, and then forming titanium on the cathode by applying voltage to the anode and the cathode.

IPC Classes  ?

• C25C 3/26 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium
• C25C 7/02 - ElectrodesConnections thereof
• C25C 7/06 - Operating or servicing

Abstract

According to an aspect, provided is an organic light-emitting element comprising a first electrode, a second electrode facing the first electrode, and a light-emitting layer interposed between the first and second electrodes, the light-emitting layer comprising a host and a dopant. The dopant is a heteroleptic iridium complex having a transition dipole moment, the horizontal orientation ratio of which is, with regard to a plane of the light-emitting layer, 75% to 100%.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)
• H01L 51/52 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED) - Details of devices

Abstract

A joint movement assistance device is disclosed. The present device comprises: a sensor part for measuring the biological information of a user; a joint fixing part fixed to a joint part of the user; a first fixing part connected to one side of the joint fixing part through a wire; a second fixing part disposed in the opposite direction of one side of the joint fixing part and connected to the joint fixing part; a power part for providing power for a joint movement of the user by providing the power to the wire; and a control part for determining intended motions of the user on the basis of the biological information measured by the sensor part, and controlling the power part regulating the power applied to the wire. Therefore, user convenience can be improved.

IPC Classes  ?

• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A61F 5/052 - Devices for stretching or reducing fractured limbsDevices for distractionsSplints for immobilising specially adapted to facilitate walking, e.g. ambulatory braces

Abstract

The present disclosure relates to a method for message flooding in a wireless communication system, and is characterized in that it includes the steps of: broadcasting, by a transmission node, a flooding message to a surrounding node through a first common channel; checking, by a reception node, whether the first common channel has received the flooding message; transmitting, by the reception node, an ACK signal through a second common channel or a NACK signal through a third common channel, based on a result of the check; and determining, by the transmission node, whether the second common channel or the third common channel has detected a signal, to determine whether to re-transmit the flooding message.

IPC Classes  ?

• H04W 28/04 - Error control
• H04W 40/02 - Communication route or path selection, e.g. power-based or shortest path routing

Abstract

Disclosed is a positioning method for estimating a location in a wireless communication system, the method characterized by comprising the steps of: a first terminal transmitting a positioning request message for positioning to a base station; the base station transmitting, to neighboring terminals within a cell, an anchor request message to find terminals which can be a second terminal; the base station receiving, from at least one terminal from among the neighboring terminals in the cell, an anchor response message corresponding to the response for the anchor request message; and the base station determining the second terminal on the basis of the received anchor response message.

IPC Classes  ?

• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

Disclosed are a method for controlling power and an apparatus therefor in a wireless communication system supporting device-to-device (D2D) communication. Specifically, a method for a terminal for controlling the transmission power of a physical sidelink discovery channel (PSDCH) in a wireless communication system supporting D2D communication comprises the steps of: calculating the sum of reception strengths of the total number of PSDCHs received from a set PSDCH reception period; and transmitting the PSDCH, wherein if the sum of reception strengths of the total number of PSDCHs is greater than a previously set threshold value, then the PSDCH to be transmitted is transmitted under the transmission power controlled by the terminal, and if the sum of reception strengths of the total number of PSDCHs is less than a previously set threshold value, then the PSDCH to be transmitted can be transmitted under the maximum transmission power.

IPC Classes  ?

• H04W 52/24 - TPC being performed according to specific parameters using SIR [Signal to Interference Ratio] or other wireless path parameters
• H04W 52/34 - TPC management, i.e. sharing limited amount of power among users or channels or data types, e.g. cell loading

Abstract

The present invention relates to a siRNA molecule having improved specificity for inhibiting target gene expression and a decreased off-target effect, the siRNA molecule having a structure of asymmetric 3'-overhangs and consisting of sense and antisense strands, wherein one of the two strands has 3'-overhangs consisting of DNA of 1 to 3 nucleotides and the other has 3'-overhangs consisting of RNA of 1 to 3 nucleotides.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a poly-γ-glutamic acid derivative, which is amphiphilic, and nanoparticles based on the same. The water dispersibility and oxidative stability of an encapsulating material can be improved by encapsulating a fat-soluble vitamin or a poorly soluble drug in the nanoparticles of the present invention, and the effective application of the encapsulating material can be achieved by using, in cosmetics or medicine, nanoparticles in which the encapsulating material is encapsulated.

IPC Classes  ?

• C08G 69/10 - Alpha-amino-carboxylic acids
• C08L 77/04 - Polyamides derived from alpha-amino carboxylic acids
• C08J 3/12 - Powdering or granulating
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

The present invention relates to a composition for promoting the differentiation of myoblasts, the composition containing butylpyridinium, a derivative thereof, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for preventing or treating muscular weakness-related diseases; a food composition for preventing or alleviating muscular weakness-related diseases; a composition for strengthening muscular strength; and a feed or feed composition for strengthening muscular strength. Furthermore, the present invention relates to a method for promoting the differentiation of myoblasts using butylpyridinium, a derivative thereof, or a pharmaceutically acceptable salt thereof; a method for manufacturing differentiated myoblasts; and a method for treating muscular weakness-related diseases.

IPC Classes  ?

• A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The present invention relates to a medium composition for inducing the differentiation into insulin-producing cells, the composition containing glucosamine; a method for inducing the differentiation into insulin-producing cells by using the medium composition, and a cell therapeutic agent for treating diabetes, containing insulin-producing cells prepared by the method. The glucosamine according to the present invention can effectively induce the differentiation into insulin-producing cells through the regulation of sugar metabolism. The induction of the differentiation into insulin-producing cells using glucosamine as described above has advantages of being safe due to the exclusion of genetic manipulation; being performed at low cost since high-priced compounds or growth factors with unidentified mechanisms are not required; and minimizing cell contamination and deformation, which are caused at the time of ex vivo manipulation, due to the induction in a short period of time.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/074 - Adult stem cells
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Disclosed are: a method for labeling exosomes with a radioactive substance using amine groups on surfaces of the exosomes; exosomes prepared thereby; an imaging composition comprising the same; and an imaging method. According to the method of the present application, the exosomes can be stably labeled at high labeling efficiency, and the exosomes prepared by the method of the present application can be favorably used as an agent for nuclear medicine imaging and therapeutic imaging for confirming the biological distribution of exosomes and the migration or not of exosomes to target organs and target diseases in animals including a human being.

IPC Classes  ?

• G01N 33/60 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances involving radioactive labelled substances
• G01N 33/534 - Production of labelled immunochemicals with radioactive label
• G01N 23/00 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo

Abstract

The present invention relates to a core-shell nanocomposite including fluorescent bodies disposed to have a uniform distance in a perpendicular direction from a surface thereof, to a method of manufacturing same, and to a use for a probe for metal-enhanced fluorescence.

IPC Classes  ?

• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A wireless transmitter according to the present embodiment comprises: a piezoelectric element for generating energy when pressure is applied thereto; a charging-discharging unit for charging the energy generated by the piezoelectric element and discharges the charged energy, wherein the energy is discharged to an energy discharge path different from an energy charging path; and a wireless transmission unit receiving the energy from the charging-discharging unit so as to transmit a predetermined code, wherein the charging-discharging unit includes a plurality of capacitors connected in series so as to charge electric energy applied by the piezoelectric element, and connected in parallel so as to discharge the charged electric energy.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
• H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
• H04B 1/02 - Transmitters

Abstract

A system for detecting a surrounding moving object using cooperative communication according to the present specification comprises: a sensing unit which has at least one sensor and detects moving objects located within the detection range of the sensor to generate sensing information; a communication unit which transmits first local measurement information indicative of traffic information of the moving objects generated on the basis of the sensing information to the outside and receives at least one second local measurement information from the outside; and a convergence processing unit which combines pre-generated extension measurement information, the first local measurement information, and the second local measurement information so as to generate new extension measurement information containing traffic information of the extension measurement information, traffic information of the first local measurement information, and traffic information of the second local measurement information.

IPC Classes  ?

• G01S 19/05 - Cooperating elementsInteraction or communication between different cooperating elements or between cooperating elements and receivers providing aiding data
• G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using radio waves

Abstract

Disclosed is a vaccine composition for Orientia tsutsugamushi. Specifically, disclosed is a vaccine composition using, as an active ingredient, ScaA, which is an autotransporter protein, or the passenger domain region thereof.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The present invention relates to a method in which lipid and DOPA are synthesized with 6-arm PEG, DOPA is synthesized with gelatin, the lipid solubility of lipid is used and thereby lipid is induced to interfere and bind between surface cell phospholipid layers of the pancreatic islet of a pig, and by using a covalent bond between DOPA and SH the surface of a pancreatic islet membrane of a pig is modified through a bond between 6-arm PEG-SH, DOPA, gelatin-DOPA and linear PEG-SH. The present invention, compared to a pure pancreatic islet that has not been given any treatment, does not show changes in pancreatic islet shape, insulin secretion and cell survivability, and by confirming the increasing of maintenance time for blood glucose concentration, stability and viability of pancreatic islet can be enhanced, thereby being effectively used in a pancreatic islet transplant.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61L 27/38 - Animal cells

Abstract

The present invention, with respect to implementing a device that is capable of being reconfigured, has significantly increased the degree of integration over existing devices that are capable of being reconfigured and have the same functions by configuring a separate upper gate and lower gate, and is able to reduce dynamic parasitic components during reconfiguring-capable circuit operations and reduce wiring complexity, on the basis of a separate lower electrode array inside the device and having a built-in nonvolatile memory function, so as to ultimately be a configuration that is capable of reducing power consumption. Also, a device is provided that shows superiority over existing devices that are capable of being reconfigured in terms of various characteristics, such as function diversity in a multifunctional device, alignment tolerances during manufacturing processes, minimum electronic doping forming ability within channels, compatibility with upstream and downstream methods of manufacturing processing, and compatibility with 1D and 2D materials.

IPC Classes  ?

• H01L 27/115 - Electrically programmable read-only memories; Multistep manufacturing processes therefor
• H01L 21/8247 - Read-only memory structures (ROM) electrically-programmable (EPROM)
• H01L 21/31 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to form insulating layers thereon, e.g. for masking or by using photolithographic techniquesAfter-treatment of these layersSelection of materials for these layers

Abstract

Disclosed is a technique capable of effectively estimating a three-dimensional location of a target node without requiring additional hardware through a geometric access by using location information of three anchor nodes. The height of a tetrahedron is calculated by calculating the volume of the tetrahedron and the area of the base plane thereof formed by three estimated distances between the three anchor nodes and the target node and by distances between the three anchor nodes. Projected estimated distances, obtained by projecting the estimated distances on a plane (H) formed by the three anchor nodes, and coordinate values of the three anchor nodes converted on a second coordinate system of the plane (H) are obtained, and then trilateration is performed using the projected estimated distances and the converted coordinate values so as to calculate an estimated location, projected on the plane (H), of the target node. A coordinate value of the calculated estimated location is converted into a coordinate value on a first coordinate system and then the height of the tetrahedron is reflected thereto so as to obtain a coordinate value of the three-dimensional estimated location of the target node. The number of required anchor nodes and the complexity of a positioning system can be decreased, calculating positioning information can be significantly simplified, and accuracy can be increased.

IPC Classes  ?

• G01S 5/14 - Determining absolute distances from a plurality of spaced points of known location
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

Provided is a method for producing graphene-based nano carbon fiber using inter-layer self-assembly. A method for producing graphene-based nano carbon fiber using inter-layer self-assembly according to one embodiment of the present invention comprises the steps of: providing oxidated nano carbon; and discharging an oxidated nano carbon dispersion solution into a coagulation bath including polyamine to produce an oxidated nano carbon gel fiber which is crosslinked by the polyamine.

IPC Classes  ?

• D06M 11/74 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbon or graphiteTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with graphitic acids or their salts
• D01D 5/00 - Formation of filaments, threads, or the like

Abstract

The present invention relates to: a method for increasing the resistance of a plant to drought stress, the method comprising a step of genetically transforming, into a plant cell, a recombinant vector comprising rice(Oryza sativa)-derived miR399f (microRNA 399f) precursor DNA, and over-expressing the OsmiR399f precursor; a production method for a transgenic plant having increased resistance to drought stress as compared with the wild type, by genetically transforming, into a plant cell, the recombinant vector comprising the OsmiR399f precursor DNA; and a composition for increasing the resistance of a plant to drought stress, the composition comprising a transgenic plant produced by means of the above method, and seeds thereof and the OsmiR399f precursor DNA as active ingredients.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy

Abstract

The present invention relates to a Raman analysis method and device for high-speed quantitative analysis of a wide-area sample which enable high-speed quantitative analysis of a plurality of search targets existing in a wide-area sample while reducing the size and cost of equipment. Unlike the conventional spot-unit-based analysis, the present invention has such effects as highly improving the speed of multidimensional multiple marker analysis by reading-out continuous spectrum information on one or more consecutive scanning intervals during one camera operation period, thus reducing the noise created by the camera operation and enhancing the scanning speed.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 21/55 - Specular reflectivity
• G01J 3/28 - Investigating the spectrum

Abstract

The present invention relates to a composition for inducing differentiation of stem cells into muscular cells and a pharmaceutical composition for preventing or treating muscle damage diseases. The present invention induces the specific differentiation of stem cells into muscular cells very efficiently by using the so-far-unknown histone deacetylase 6 (HDAC6) as a new differentiation regulation target. The present invention can be favorably used to prevent or treat various muscle damage diseases, such as muscular dystrophy, muscular inflammation, and fibrosis, by regenerating lost muscular tissues.

IPC Classes  ?

• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

A PoP nanostructure comprises a first nanoparticle loading a drug, and second nanoparticles surrounding a surface of the first nanoparticle and coated with protein alpha-synuclein. The protein alpha-synuclein enables the conjugation of nanoparticles and the control of drug release.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 47/02 - Inorganic compounds
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein

Abstract

Disclosed are a gene packaging method using ultrasonic waves and an apparatus for implementing the same. The gene packaging method comprises the steps of: holding a solution containing a gene; determining ultrasonic irradiation conditions including the intensity and time of ultrasonic waves to be irradiated depending on the amount and length of the gene contained in the solution; and irradiating ultrasonic waves, corresponding to the ultrasonic wave irradiation conditions, to the solution such that the gene is wound or folded by radiation force to have a changed shape. Therefore, the cell transduction rate or delivery efficiency of the gene is improved, and thus the effect of the gene on disease treatment can be improved.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The present invention relates to a pharmaceutical composition for preventing and treating breast cancer, containing an Inula helenium fraction or a compound isolated therefrom as an active ingredient. More specifically, the present invention exhibits selective inhibitory effects on tyrosine phosphorylation activity of STAT3 in breast cancer cells and in a mouse in which breast cancer cells have been transplanted, effectively inhibits the expression of STAT3 target genes, effectively suppresses cancer metastasis, and effectively reduces the weight and volume of a tumor. Therefore, the Inula helenium fraction or the compound isolated therefrom can be effectively used as an active ingredient of a pharmaceutical composition for preventing or treating breast cancer, a composition for suppressing breast cancer metastasis, a functional health food for preventing and alleviating breast cancer, a functional health food for suppressing breast cancer metastasis, or an anticancer adjuvant.

IPC Classes  ?

• A61K 36/28 - Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• A61P 35/00 - Antineoplastic agents

Abstract

The purpose of the present invention is to provide a strip cast magnesium alloy board, wherein the solidification range of a magnesium alloy is controlled by adding, on the basis of a Mg-Al alloy system, an alloy element such as manganese (Mn), tin (Sn), calcium (Ca) or misch metal (Mm), thereby controlling the segregation fraction generated in a strip casting process, and thus the magnesium alloy board has excellent mechanical properties compared with a conventional magnesium alloy board. A magnesium alloy board for strip casting according to the present invention is a Mg-Al-Mn-X (X= Ca or RE) alloy system comprising Al in an amount of more than 3.0 wt% and less than or equal to 10.0 wt% and 0.1-3.0 wt% of Mn, and comprising 0.1-5.0 wt% of Ca or 0.1-5.0 wt% of a rare earth metal and the balance of magnesium and inevitable impurities, and a Mg-Al-Sn-X (X=Ca or RE) alloy system comprising Al of 3.0-10.0 wt%, 0.1-6.0 wt% of Sn and 0.1-0.3 wt% of Mn, and comprising 0.1-5.0 wt% of Ca or 0.1-5.0 wt% of a rare earth metal and the balance of magnesium and inevitable impurities, and thus the segregation fraction of the board is less than or equal to 2.5%.

IPC Classes  ?

• C22C 23/02 - Alloys based on magnesium with aluminium as the next major constituent
• B22D 21/04 - Casting aluminium or magnesium
• B22D 11/06 - Continuous casting of metals, i.e. casting in indefinite lengths into moulds with travelling walls, e.g. with rolls, plates, belts, caterpillars

Abstract

The present invention relates to a method for increasing resistance to non-biological stress of a plant, the method comprising a step of transfecting plant cells with a recombinant vector including an Oryza sativa-derived nuclear factor Y, subunit A7 (NF-YA7) protein coding gene, and the Oryza sativa-derived NF-YA7 protein coding gene of the present invention can be favorably used to develop a transgenic plant with increased resistance to drought stress.

IPC Classes  ?

• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy

Abstract

Disclosed are a method for mitigating interference in a wireless communication system supporting device-to-device (D2D) communication, and a device for same. A method, for mitigating interference in D2D communication in a wireless communication system supporting D2D communication, can particularly comprise the steps of: a device receiving a D2D signal; the device determining whether or not interference occurs in resources in which the D2D signal has been transmitted; and, if interference is determined to have occurred in the resources in which the D2D signal has been transmitted, the device transmitting interference resource information for indicating that the interference has occurred in the resources in which the D2D signal has been transmitted.

IPC Classes  ?

• H04J 11/00 - Orthogonal multiplex systems

Abstract

The present invention provides a guide RNA capable of recognizing AAVS1 in canine cells, a composition containing the same, and a method for producing a canine cell line capable of stably expressing a foreign gene using the same. The foreign gene can be stably expressed in the canine cell line by using the present invention. Therefore, the present invention can be favorably used for the studies of diagnostic and therapeutic purposes using genes, and can be further applied to the production of cell lines expressing proteins useful to people.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

A washing machine includes a tub; a drum rotatably disposed inside the tub; and an ultrasound generator configured to emit ultrasonic waves to washing water loaded in the drum, and to generate bubbles. The ultrasound generator applies ultrasonic energy to the washing water to cause chaotic oscillation of the bubbles.

IPC Classes  ?

• D06F 19/00 - Washing machines using vibrations for washing purposes

Abstract

The present invention relates to a movable apparatus for collecting floating matters and, more particularly, to a movable apparatus for collecting floating matters, which is moved on the ground by means of a vehicle, separated from the vehicle in the body of water from which floating matters are to be collected, and mounted on the side of a vessel so that the apparatus can collect floating matters from the surface of water. The present invention provides a movable apparatus for collecting floating matters, comprising: a collection tank; a buoyant body surrounding the collection tank; wheels equipped on the buoyant body; and a vehicle connector for connecting the buoyant body to the vehicle. Accordingly, the present invention is capable of collecting floating matters after quickly moving to a natural water system from which floating matters are to be collected.

IPC Classes  ?

• B63B 35/32 - Vessels or similar floating structures specially adapted for specific purposes and not otherwise provided for for collecting pollution from open water
• E02B 15/04 - Devices for cleaning or keeping clear the surface of open water from oil or like floating materials by separating or removing these materials

Abstract

The present invention relates to a phenoxyacetyl derivative compound and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating nonalcoholic fatty liver disease. The compound according to the present invention is excellent in the inhibition of SREBP-1c activity and FAS expression, and is thus expected to be able to be usefully used as an active ingredient of a pharmaceutical composition or a functional food composition for preventing, ameliorating or treating nonalcoholic fatty liver disease.

IPC Classes  ?

• C07C 235/24 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to a pharmaceutical composition containing a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating non-alcoholic fatty liver disease. More specifically, it was established that the GPR119 ligand, which has been developed as only an anti-diabetic medicine, exhibits an excellent effect in the treatment of non-alcoholic fatty liver, and the signaling pathway in liver cells therefor is different from the signaling pathway in the small intestine or pancreas exhibiting an anti-diabetic effect, and thus it was confirmed that the GPR119 ligand can be useful to treat non-alcoholic fatty liver.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/4245 - Oxadiazoles
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention relates to an electrode catalyst, a method for preparing the same, and a membrane electrode assembly and a fuel cell comprising the same, wherein the electrode catalyst includes a carbon based carrier and a platinum based catalyst carried on the carbon based carrier, and the carbon based carrier is selectively bonded to a thermally reactive polymer. The electrode catalyst can smoothly discharge water generated as a result of electrochemical reaction, and thus improve the electrical performance of the fuel cell.

IPC Classes  ?

• H01M 4/90 - Selection of catalytic material
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 8/02 - Fuel cellsManufacture thereof Details

Abstract

The present invention provides a screening method for a therapeutic agent of GPCR19-related condition. In addition, the present invention provides an efficacy analysis method for a GPCR19 agonist. Also, the present invention provides a myeloid-derived suppressor cell (MDSC) which is formed by being treated with an in vivo physiological activity regulator and a GPCR19 agonist, and has Gr-1+CD11b+ surface phenotype and anti-inflammatory activity. Also, the present invention provides an immunoregulatory B cell which is formed by being treated with an in vivo physiological activity regulator and a GPCR19 agonist, or is formed by the H-MDSC treatment, and has B220+ surface phenotype and anti-inflammatory activity. Also, the present invention provides an anti-inflammatory pharmaceutical composition comprising an H-MDSC or BHM cell as an active ingredient. Also, the present invention provides an anticancer pharmaceutical composition comprising an H-MDSC, 48H BH or BHM cell as an active ingredient. Also, the present invention provides an anti-inflammatory pharmaceutical composition comprising a GPCR19 agonist which is composed for the purpose of in vivo amplifying an H-MDSC or 48H BH cell. According to the present invention, the number of H-MDSCs is increased by administration of sodium taurodeoxycholate (HY-2191) in a mouse in which inflammation is induced by administration of lipopolysaccharide (LPS), and the increased H-MDSCs reveal a marked therapeutic effect on sepsis. According to the present invention, the number of immunoregulatory B cells (48h BH cells) is increased by administration of sodium taurodeoxycholate (HY-2191) in a mouse in which inflammation is induced by administration of lipopolysaccharide (LPS), and the increased 48h BH cells reveal a marked therapeutic effect on sepsis. According to the present invention, the number of BHM cells is increased by administration of H-MDSC in a mouse in which inflammation is induced by administration of lipopolysaccharide (LPS), and the increased BHM cells reveal a marked therapeutic effect on sepsis.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 5/0781 - B cellsProgenitors thereof

Abstract

A high-speed frame exchange method that increases the efficiency of a resource and enables reliable transmission is disclosed. A method performed by a terminal includes the steps of: receiving a first downlink data frame including a specific field where a bit value requesting a response using a data frame from an access point is set; and transmitting a second uplink data frame to the access point in response to the first downlink data frame based on the bit value of the specific field. Thus, since it is possible to respond to data frame reception by using another data frame, it is possible to increase the efficiency of a resource.

IPC Classes  ?

• H04B 7/26 - Radio transmission systems, i.e. using radiation field for communication between two or more posts at least one of which is mobile

Abstract

The present invention relates to a protein, wherein the hydroxylation and oxidation of a tyrosine moiety of a protein is catalyzed with high efficiency by using actinomycete-derived tyrosinase, and remarkable adhesion, high thermal stability and mechanical stability are provided through the cross-linking of a catechol- or quinone-structured material generated thereby. In addition, it is possible to immobilize an enzyme and prepare a biocompatible material by applying the protein.

IPC Classes  ?

• C12P 21/04 - Cyclic or bridged peptides or polypeptides, e.g. bacitracin
• C12N 11/06 - Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
• A61L 24/10 - PolypeptidesProteins
• A61L 27/22 - Polypeptides or derivatives thereof

Abstract

The present invention relates to a biomarker for evaluating or predicting patient's therapeutic response to metformin, and a use thereof. The present invention relates to a composition and kit for evaluating and predicting patient's therapeutic response to metformin, the composition and the kit each containing an agent capable of detecting at least one microorganism selected from the group consisting of Blautia, Shigella, and Clostridium. Further, the present invention relates to a method for detecting at least one microorganism selected from the group consisting of Blautia, Shigella, and Clostridium, from a sample of the patient, in order to provide information necessary for evaluating or predicting the response to metformin.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

In the present invention, a copper electrode having a nanohole structure is prepared by using a polymer substrate in the form of nanopillars in order to avoid fatigue fracture that causes degradation of electrical and mechanical properties of a flexible electrode during repetitive bending of a typical metal electrode. The nanohole structure may annihilate dislocations to suppress the initiation of fracture and may blunt crack tips to delay the propagation of damage. Therefore, the nanohole electrode exhibits very small changes in electrical resistance during a bending fatigue test.

IPC Classes  ?

• B05D 5/00 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
• H05K 1/09 - Use of materials for the metallic pattern
• H05K 3/14 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using spraying techniques to apply the conductive material

Abstract

A method for simulating a circuit according to the present embodiment comprises the steps of: receiving an input of a circuit and stimulation in the form of a basis function; obtaining a transfer function of the circuit and a formula for an s domain related to the stimulation in the form of the basis function; and calculating the transfer function and the formula for the s domain expressing the stimulation, and obtaining a response, which is converted into a formula for a time domain of the circuit, to the stimulation in the form of the basis function.

IPC Classes  ?

• G01R 31/28 - Testing of electronic circuits, e.g. by signal tracer
• G01R 31/317 - Testing of digital circuits
• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines

Abstract

A method for simulating a circuit according to the present embodiment comprises the steps of: receiving an input of a circuit and stimulation in the form of a basis function; obtaining a transfer function of the circuit and a formula for a complex frequency domain related to the stimulation in the form of the basis function; and calculating the transfer function and the formula for the complex frequency domain expressing the stimulation, and obtaining a response, which is converted into a formula for a time domain of the circuit, to the stimulation in the form of the basis function.

IPC Classes  ?

• G01R 31/28 - Testing of electronic circuits, e.g. by signal tracer
• G01R 31/317 - Testing of digital circuits
• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines

Abstract

The present invention relates to a modularized patient-specific registration guide and a system using the same and, more specifically, to a modularized patient-specific registration guide capable of rapidly carrying out an initial registration step for a bone, which is a surgical site, and inducing a registration step to be easily performed even during an operation, and a system using the same. The modularized patient-specific registration guide, according to one embodiment of the present invention, is a registration guide manufactured according to a three-dimensional shape of a bone obtained in an imaging device, the registration guide comprising: a first member having one or more markers and one or more extending parts that come in contact with the bone, and having a groove on one side thereof; and a second member accommodated in or separable from the groove of the first member and having one or more markers.

IPC Classes  ?

• A61B 17/90 - Guides therefor
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
• A61F 2/46 - Special tools for implanting artificial joints

Abstract

The present invention relates to: a method for inducing tailored pluripotent stem cells by reprogramming differentiated cells of an adult by using an extract of plant stem cells and plant dedifferentiated stem cells (callus); pluripotent stem cells produced by means of the method; and a cell therapy agent comprising the pluripotent stem cells. According to the present invention, it is possible to overcome ethical problems since eggs are not used in the making of pluripotent stem cells having abilities like embryonic stem cells, and it is possible to produce pluripotent stem cells of ensured safety because use is made of a plant stem cell extract which above all has been verified to be harmless to the body, and it is also possible to use the invention to develop an immunocompatible cell therapy agent tailored to different individuals. In addition, the invention can be expected to be used to great advantage in elucidating the causes and studying methods of treating medical conditions by inducing pluripotent stem cells from individuals having diseases.

IPC Classes  ?

• C12N 5/04 - Plant cells or tissues
• A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof

Abstract

The present invention relates to a method for manufacturing water-dispersible silica nanoparticles. More specifically, the present invention relates to a method for manufacturing silica nanoparticles, which includes a step of carrying out a reaction by adding an alkaline substance and a silica precursor to a solution obtained by dissolving polyvinyl pyrrolidone in a mixed solution of C1-C4 alcohol and water.

IPC Classes  ?

• C01B 33/12 - SilicaHydrates thereof, e.g. lepidoic silicic acid
• C08F 26/10 - N-Vinyl-pyrrolidone
• C08J 3/12 - Powdering or granulating
• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

The present invention relates to a method and a system for wirelessly transmitting electric power, and a computer-readable recording medium. According to an aspect of the present invention, provided is a system for wirelessly transmitting electric power, the system including a transmission antenna, a reception antenna spaced apart from the transmission antenna by a changing distance, and a source consisting of a D type power amplifier for supplying electric power to the transmission antenna. According to the present invention, even in an environment in which an operation frequency of a wireless power transmission system is fixed and the distance between the transmission antenna and the reception antenna changes, a high power transmission efficiency can be maintained only through a simple control of the D type power amplifier or load impedance.

IPC Classes  ?

• H02J 17/00 - Systems for supplying or distributing electric power by electromagnetic waves

Abstract

The present invention relates to a method for producing a collagen scaffold coated with apatite by processing a surface of the collagen scaffold with a simulated body fluid of pH 8-13. The collagen scaffold coated by apatite, according to the present invention, is effectively produced in a short period of time and is modified so as to have osteanagenesis effects including excellent biocompatibility, cell compatibility, osteoconductive properties, and osteogenic protein sustained-release properties, and is thus useful as a medical graft material.

IPC Classes  ?

• A61L 27/56 - Porous or cellular materials
• A61L 27/24 - Collagen
• A61F 2/28 - Bones

Abstract

The present invention relates to a method of a terminal subscribing to a network via a router or an end device in a wireless network (WN) of a tree structure comprising routers and end devices. According to the present invention, each router receives, from the parent router thereof, addresses which can be used independently for child routers or child end devices thereof, and divides the addresses into general addresses and special addresses. The present invention allows a terminal wishing to subscribe to a network to subscribe to the network by using a special address of the end device, only when the terminal cannot subscribe to the network by using a general address of the end device, thereby minimizing address depletion to be used for subscription of terminals and facilitating the end devices to subscribe a network. Additionally, if a router determines that end devices of peripheral devices have finished subscription to a network, the router selects as many child end devices having a low received signal strength (RSS) (i.e., easy to extend a network remotely) as the number of general addresses available for child routers and then converts the child end devices to child routers, thereby providing network extensibility by an increase in network depth and minimizing the use of the special addresses by the router. Furthermore, if a terminal wishing to subscribe to a network via an end device fails to subscribe to the network, or a terminal which has subscribed to a network via a router wishes to re-subscribe to the network, the present invention facilitates such a terminal to re-subscribe to the network by allowing the terminal to subscribe to the network using a special address for the router. Compared to conventional techniques, the present invention can significantly enhance the success rate of subscription to a large-scale WN through the two-step address allocation and the selection of the child routers.

IPC Classes  ?

• H04L 12/753 - Routing tree discovery, e.g. converting from mesh topology to tree topology

Abstract

The present invention provides an organic light-emitting diode comprising a light-emitting layer which contains a dopant having improved horizontal orientation properties and employs a host/dopant system. One embodiment of the organic light-emitting diode according to one aspect of the present invention comprises: an anode layer; a light-emitting layer which is disposed on the anode layer and comprises a host comprising a hole transport material and an electron transport material, which form an exciplex, and a dopant comprising an Ir(mphmq)2tmd-based phosphor; and a cathode layer disposed on the light-emitting layer.

IPC Classes  ?

• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)