Abstract

A computer implemented method for performing quantum calculations in a quantum neural network is described. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A quantum computation system for performing quantum calculations in a quantum neural network and a quantum computation system for implementing a quantum neural network are also described.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present invention concerns an apparatus (1) for inducing and/or controlling the flow of a fluid in a microfluidic circuit (200) of a microfluidic device (100) comprising a pumping station (15), comprising a pumping liquid (15') and a pad (5), configured to absorb said pumping liquid (15') present in said pumping station (15), said pad (5) being so adapted to induce a flow of a fluid present in a microfluidic circuit (200) in fluid communication with said pumping station (15), wherein said pad (5) has a three-dimensional shape, adapted to define a three-dimensional absorption volume, partially insertable into, and removable from, said pumping station (15) to induce and/or control the flow of said fluid.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A photoacoustic sensor for spectroscopic gas detection includes a chamber to contain the gas; an excitation laser source that emits a modulated laser beam; a transducer, having a reflective portion, located inside the chamber; an interferometer having first and second arms and an output, the first arm ending in the transducer, and the second arm including an optical path changer element and an actuator connected to the optical path changer element to change the optical path defined by the second arm of the interferometer; a first polarizing beam splitter; a second laser source; a second polarizing beam splitter; a first detector; a second detector; an electronic circuit; and a feedback loop adapted to command the movements of the actuator in order to change and stabilize the optical path of the second arm, so that the difference signal is kept equal to a desired constant value during the gas concentration measurements.

IPC Classes  ?

• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated

Abstract

A superconducting bipolar thermoelectric memory includes a memory cell, a connection in parallel between a bipolar thermoelectric element and a predetermined resistive load, and a writing element. A current generator is arranged to send an injected current to the thermoelectric element and the resistive load. The thermoelectric element is arranged to be heated by a predetermined thermal gradient and to generate corresponding output voltages on the resistive load depending on the sign of the injected current at the writing stage. The output voltages correspond to respective stable logic states stored by the memory resetting the bias current to zero.

IPC Classes  ?

• G11C 11/44 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using super-conductive elements, e.g. cryotron
• H10N 10/855 - Thermoelectric active materials comprising inorganic compositions comprising compounds containing boron, carbon, oxygen or nitrogen
• H10N 60/10 - Junction-based devices

Abstract

The invention relates to short peptides, of amino acids in length, capable of binding with high affinity to the MDM2 protein and interfering with the MDM2/MDM4 heterodimer activity, thereby hindering the inhibitory function of the heterodimer against the tumor suppressor p53. The invention also relates to the use of the aforementioned peptides, or nucleic acid molecules encoding them, in the treatment of a tumor, preferably a solid tumor expressing wild-type p53.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present disclosure relates to a method comprising: providing a quantum register comprising a set of qubits defining a quantum system. The states of a computational basis of the quantum system may be represented by an ordered set of consecutive nonnegative integer numbers, referred to as a set of indexes. A random variable may be determined in accordance with a predefined classical-quantum format, wherein the random variable is valued in a finite domain of classical values such that each value of the domain is derived from a respective index of the set of indexes through an affine relationship, the affine relationship being defined by a scaling factor and an offset factor. The set of qubits may be encoded such that the probability of measuring a state of the quantum system in the computational basis is the probability of observing the domain value associated with the index representing said measured state when sampling the random variable.

IPC Classes  ?

• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
• G06F 7/499 - Denomination or exception handling, e.g. rounding or overflow

Abstract

Polymeric scaffold (10) for myocardial regeneration and protection, comprising a support structure (20) comprising at least a first and a second support layers (30a; 30b) and at least one inner layer (33) interposed between said first and second support layers (30a; 30b), wherein said first and second support layers (30a; 30b) comprise at least one polymeric material selected from the group consisting of poly(lactic-co-glycolic acid) (PLGA), poly(dioxanone) (PDS), polycaprolactone (PCL), and polyhydroxyalkanoates (PHA), preferably poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), optionally in combination with at least one biological polymer. At least one of said support layers (30a; 30b) further comprises at least one organic and biodegradable semiconducting material, preferably an organic and biodegradable semiconducting peptide. The at least one inner layer (33) comprises a hydrogel, preferably containing an organic and biodegradable semiconducting material, more preferably an organic and biodegradable semiconducting peptide. The support layers (30a; 30b) furthermore comprise a surface sculpture, said surface sculpture comprising a plurality of cavities (41) arranged according to a regular frame, said cavities (41) being defined by an array of longitudinal linear projections (40a, 40b) and an array of transverse linear projections (40c) intersecting each other respectively, said first and second support layers (30a; 30b) having cavities (41) respectively facing opposite sides of the support structure (20).

IPC Classes  ?

• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

33 adenosine receptor ligand such as piclidenoson or namodenosone.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A method for forming a graphene layer on a semiconductor substrate, a semiconductor diode utilizing the method for graphene layer formation, and an optoelectronic semiconductor device also utilizing the method for graphene layer formation are provided. An example method for disposing a graphene layer on a semiconductor substrate may include depositing a metal catalyst layer on a top surface of the semiconductor substrate and patterning the metal catalyst layer, such that one or more portions of the top surface of the semiconductor substrate are covered by one or more metal catalyst layer structures. The method may further include facilitating a graphene growth process on an exposed surface of the one or more metal catalyst layer structures, wherein the graphene growth process forms the graphene layer on the exposed surfaces of the one or more metal catalyst layer structures.

IPC Classes  ?

• H01L 29/872 - Schottky diodes
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/66 - Types of semiconductor device

Abstract

Described is a scintigraphic intracavitary measurement device (100) comprising a supporting rod (10) extending along a main direction of extension (X) and a measuring head (20) coupled or integrated with a first end (10a) of said supporting rod (10). The measuring head (20) comprises at least one collimation element (30) configured to filter gamma radiation emitted by a source (S) defined by a suitably energised body tissue and a scintillation unit (40) configured to detect the gamma radiation emitted by the body tissue and filtered by the collimation element (30). The measuring head (20) is configured to operate with variable investigation areas (A).

IPC Classes  ?

• G01T 1/164 - Scintigraphy

Abstract

A compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: A compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: wherein R is chosen from phenyl, a 6-membered heteroaryl group, cyclohexyl, a 5-membered heteroaryl group; a bicyclo [3.1.0] hexanyl group; a C2-C5 alkynyl group; and a cubanyl group; wherein R1 and R2, independently, are chosen from H; C1-C6 alkyl (optionally substituted with one or more halogens); C1-C6 alkyl-S(O)n—; CO2H (or C1-C6 alkyl esters thereof or C1-C6 alkyl amides thereof); halogen; C1-C6 alkoxy; CN; NO2; and NR7R8; wherein R7 and R8, independently, each represent H, C1-C6 alkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl, heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl, or C1-C6 alkylsulphonyl, or R7, R8 and the nitrogen to which they are attached form a 5 or 6 membered heterocyclic ring (such as morpholine or piperidine); and wherein n represents 0-2.

IPC Classes  ?

• C07D 473/06 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61Q 19/08 - Anti-ageing preparations
• C07C 273/18 - Preparation of urea or its derivatives, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
• C07D 239/545 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Abstract

mnnmm is equal to 2 or 3, R1366Fs - COOR2and -CONR3R4, wherein R2, R3and R4are independently selected from hydrogen, linear or branched alkyls having from 1 to 4 carbon atoms or aryls preferably selected from phenyl, 2- methylbenzene, 2,4-dimethylbenzene, 2,4,6-trimethylbenzene, k is the charge of the complex and is equal to 0 or +1, and X is an anion, preferably selected from Cl-44 -66 - j j is the coefficient of the anion X and is equal to 0 or 1.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

The present invention concerns a scheme that allows to create a Quantum-to-Quantum Bernoulli Factory, wherein random bits and qubits can be generated given input qubits, using a quantum photonic system that can take advantage of the different information coding approaches using states of single photons According to the invention, inversion, multiplication and sum operations can be realized with photon qubits and can be concatenated without generating noise.

IPC Classes  ?

• G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
• G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena

Abstract

A method for detecting a viral agent including the steps of placing a first sample that includes an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on the parameters for assessing the presence of a viral agent in at least one of the samples.

IPC Classes  ?

• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention concerns an endoscopic device (D) for sampling a sample of gastrointestinal content, comprising: an inner support (1 ), extending along an axis (X), from a first end (11 ) toward a second end (12); an outer support (2), capable of surrounding said inner support (1 ); a reservoir (3), extending along an axis X, arranged within said inner support (1 ); a plurality of permanent magnets (5), activatable by a magnetic field and configured to rotate said inner support (1 ), outer support (2) and reservoir (3) independently of each other around said axis (X); said device (D) being characterized in that said reservoir (3) includes a solution for storing said sample, and in that at least one contact and sampling element (321; 341 ) is arranged on said reservoir (3), said contact and sampling element (321; 341 ) being capable of switching from a resting position in which it is in a sterile condition, to an operating position in which it is capable of sampling the sample, and to a sample storage position in which it is in contact with said solution, within said inner support (1 ). The present invention also concerns a sampling system comprising the device (D) and an external magnet (M). The present invention also concerns a method of operation of the system.

IPC Classes  ?

• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• A61B 10/04 - Endoscopic instruments, e.g. catheter-type instruments
• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

A method for manufacturing a medical patch for the treatment of chronic vascular and diabetic ulcers comprises the steps of preparing a tubular support, spraying toward the axial lateral surface of said support at least two separate, simultaneous, converging jets of two nebulized solutions containing fibrinogen and thrombin, respectively, rotating the support and/or orienting the jets in such a way as to deposit on said support a layer of material (M) of predetermined size, and incubating the material (M) until the fibrin contained therein is polymerized.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61K 35/19 - PlateletsMegacaryocytes
• A61K 38/36 - Blood coagulation or fibrinolysis factors
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• B29C 41/08 - Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
• B29C 41/46 - Heating or cooling
• B29K 105/00 - Condition, form or state of moulded material
• B29L 31/00 - Other particular articles

Abstract

A power transistor (1) for a semiconductor device, comprising: a support layer (2) made of Silicon Carbide with a bottom surface (21), at least one epitaxial layer (3) grown on its top and having a top surface (31) opposite to the bottom surface (21) along a first direction (X-X); a drain (4) arranged at least partially on the bottom surface (21); a plurality of gates and sources (5) alternately arranged on the top surface (31) and spaced apart from each other along a second direction (Y-Y); a plurality of inversion channel regions (7) generated within the thickness of the epitaxial layer (3) for transporting charges, each inclined relative to the top surface (31) by an inclination angle (α), ranging from 1° to 5°, substantially equal to the crystal basal planes (200) inclination angle (201), and each comprising a step free-area (111) and being devoid of accumulation areas (112).

IPC Classes  ?

• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/66 - Types of semiconductor device
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate

Abstract

A sensorized device (100) for detecting analytes within a fluid comprising a piezoelectric substrate (105) having an outer surface (105'), at least one R-SAW emitting interdigital transducer (111) arranged on the outer surface (105') and arranged to emit a surface acoustic wave of the Rayleigh type, also-called R-SAW, in response to an electrical input signal, said R-SAW being emitted along a first emission direction x, and at least one SH-SAW emitting interdigital transducer (112) arranged on the outer surface (105') and arranged to emit a surface acoustic wave of the shear-horizontal type, also-called SH-SAW, in response to an electrical input signal, said SH-SAW being emitted along a second emission direction y. In particular, the piezoelectric substrate (105) is made of a material selected from 64° Y-cut lithium niobate and 163° Y-cut lithium niobate, in such a way that the piezoelectric substrate (105) supports as its main mode surface acoustic waves of the shear-horizontal type, the main mode being defined as the surface acoustic wave exhibiting greater electromechanical coupling on the piezoelectric substrate (105). Furthermore, the first emission direction x and the second emission direction y have a relative angle a in such a way that 80° < α < 100°.

IPC Classes  ?

• G01N 29/02 - Analysing fluids
• G01N 29/036 - Analysing fluids by measuring frequency or resonance of acoustic waves
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• G01N 29/24 - Probes

Abstract

A vector for central nervous system (CNS)-specific expression, wherein the vector comprises a transgene encoding interleukin 10 (IL-10), and wherein the transgene is operably linked to one or more expression control sequence.

IPC Classes  ?

• A61K 38/20 - Interleukins
• C12N 15/67 - General methods for enhancing the expression
• C12N 15/861 - Adenoviral vectors
• C12N 15/864 - Parvoviral vectors
• C12N 15/867 - Retroviral vectors

Abstract

The present invention relates to a computer-implemented method and corresponding apparatus for the accurate identification of subcellular structures from tomographic reconstructions. This invention allows to extract the 3D subcellular specificity directly from the tomographic phase-contrast data obtained from a typical flow cytometry configuration or any other experimental tomographic systems able to provide 3D quantitative phase-contrast tomograms. In particular, subcellular structures can be identified by using a novel computational segmentation method based on statistical inference from any 3D phase-contrast tomographic data.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/10 - Investigating individual particles
• G01N 15/1429 - Signal processing
• G01N 15/1434 - Optical arrangements
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/762 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using clustering, e.g. of similar faces in social networks

Abstract

The present patent application describes microRNAs for the diagnosis and development of advanced therapies for amyotrophic lateral sclerosis (ALS) with bulbar onset.

IPC Classes  ?

• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

Disclosed is an apparatus and a method. Spin-splitting is induced at a superconductor and spin-polarization facilitated for tunneling across a tunnel barrier so that electric current across the tunnel barrier between a conductor and the superconductor flows primarily in one direction.

IPC Classes  ?

• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region
• H10N 60/10 - Junction-based devices

Abstract

A Process for the preparation of a functionalized terpolymer having general formula (I): A Process for the preparation of a functionalized terpolymer having general formula (I): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): provided that in the general formula (IV) at least one of between R5, R6 and R7 differs from hydrogen and at least one of between R5, R6 and R7, contains one of the following functional groups: —COOH, —COO−M+, —SO3H, —SO3−M+, —SO2H, —SO2−M+, —OPO3H2, —OPO32−M+2, —PO3H2, —PO32−M+2, —OH, A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): provided that in the general formula (IV) at least one of between R5, R6 and R7 differs from hydrogen and at least one of between R5, R6 and R7, contains one of the following functional groups: —COOH, —COO−M+, —SO3H, —SO3−M+, —SO2H, —SO2−M+, —OPO3H2, —OPO32−M+2, —PO3H2, —PO32−M+2, —OH, The above process allows for terpolymers to be obtained which are soluble in polar solvents such as, for example, water, methanol, ethanol, butanol, acetone or dimethyl sulfoxide. The terpolymers can be advantageously used, for example, as additives for cements.

IPC Classes  ?

• C08G 64/34 - General preparatory processes using carbon dioxide and cyclic ethers
• C04B 24/28 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• C08G 64/02 - Aliphatic polycarbonates
• C08G 64/42 - Chemical after-treatment

Abstract

A method is described for extracting a gaseous or vapor component from compressed air produced by a compressor equipped with a compression chamber. The compressed air in the compression chamber is heated by the compression, is cooled at the outlet of the compression chamber, and sent to a capture device into which an absorbent fluid simultaneously enters and operates to purify it of said component. The absorbent fluid exits enriched of said component from the capture device, is heated by withdrawing heat generated by the compression process occurring in the compression chamber, and then enters a release device wherein said component desorbs into the absorbent fluid to release, at an outlet of the release device, said component extracted from the compressed air.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption

Abstract

A polynucleotide comprising a nucleotide sequence encoding methyl-CpG binding-protein 2 (MeCP2) and: (a) at least one miR-124 target sequence, and/or at least one miR-31 target sequence, and/or at least one miR-338-3p target sequence; and/or (b) a nucleotide sequence encoding an inhibitor of MeCP2 expression, optionally a nucleotide sequence encoding an shRNA that has at least 90% sequence identity to SEQ ID NO: 15, 30 or 31.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

A process for the preparation of a doped photomobile polymer characterised by having no rubbing stage, as well as the photomobile polymer obtained by said process and a method of 3D-printing said photomobile polymer or comprising arranging a tank configured to contain a predetermined amount of a non-cross-linked resin of said photomobile polymer are described.

IPC Classes  ?

• C09K 19/52 - Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives
• H01L 31/042 - PV modules or arrays of single PV cells
• H01L 31/048 - Encapsulation of modules
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• H02S 20/32 - Supporting structures being movable or adjustable, e.g. for angle adjustment specially adapted for solar tracking
• C09K 19/04 - Liquid crystal materials characterised by the chemical structure of the liquid crystal components
• B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials

Abstract

A process for the preparation of a doped photomobile polymer characterised by having no rubbing stage is described, as well as the photomobile polymer obtained by said process and a handling device for moving a single solar cell to a photovoltaic panel comprising said photomobile polymer.

IPC Classes  ?

• C09K 19/52 - Liquid crystal materials characterised by components which are not liquid crystals, e.g. additives
• H01L 31/042 - PV modules or arrays of single PV cells
• H01L 31/048 - Encapsulation of modules
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• H02S 20/32 - Supporting structures being movable or adjustable, e.g. for angle adjustment specially adapted for solar tracking
• C09K 19/04 - Liquid crystal materials characterised by the chemical structure of the liquid crystal components

Abstract

A method of evaluating the functionality of a preparation of extracellular vesicles (EVs) is described, which comprises incubating said preparation with fluorescein diacetate (FDA) as a non-fluorescent precursor of fluorescein under suitable conditions so that fluorescein diacetate enters the EVs of the preparation and is hydrolysed by endogenous esterase enzymes, thereby forming fluorescence-emitting fluorescein molecules. The amount of fluorescein produced, as it is related to the specific intravesicular enzymatic activity, provides a quantitative measure of the functionality of the EV preparation, i.e., the bioactivity, in particular the enzymatic activity, and integrity parameters of the vesicle membranes.

IPC Classes  ?

• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

Devices including a plurality of antennae, methods for using the devices, and methods of diagnosing and treating a disease are disclosed.

IPC Classes  ?

• A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves using microwaves or terahertz waves
• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61N 5/02 - Radiation therapy using microwaves

Abstract

It is disclosed a portable system for detecting an object at least partially hidden by a flame. The system comprises a first portable device comprising a fiber optic laser emitting an infrared radiation. The system also comprises a second portable device comprising a fiber optic splitter optically coupled to the fiber optic laser and an infrared detector. The fiber optic splitter divides the infrared radiation into an object beam and a reference beam, directs the object beam onto the object to be detected and directs the reference beam onto the infrared detector. The infrared detector detects a hologram formed by the reference beam interfering with the object beam scattered by the object. The system further comprises a data processing unit which reconstructs images of the object by numerically processing the hologram, and a display which visualizes the reconstructed images.

IPC Classes  ?

• G03H 1/02 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto Details
• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/08 - Synthesising holograms
• G02F 1/313 - Digital deflection devices in an optical waveguide structure
• G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto
• G03H 1/26 - Processes or apparatus specially adapted to produce multiple holograms or to obtain images from them, e.g. multicolour technique
• G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
• G02B 27/30 - Collimators
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G08B 21/04 - Alarms for ensuring the safety of persons responsive to non-activity, e.g. of elderly persons

Abstract

A heterostructure (1) based on single-element atomic layers can be integrated into a substrate of a semiconductor electronic device. The heterostructure (1) comprises a first two-dimensional layer (3) made with a first air-sensitive material, a second two-dimensional layer (4) made with a second air-sensitive material, and a protective layer (5). A conductive layer (2) covers a portion of the first two-dimensional layer (3), so that the uncovered part (O) of the first two-dimensional layer (3) is exposed to an oxidizing atmosphere and the uncovered part (O) is oxidized.

IPC Classes  ?

• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 21/336 - Field-effect transistors with an insulated gate
• H01L 29/165 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form including two or more of the elements provided for in group in different semiconductor regions
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

A device for air sanitation in circumscribed environments generates a sterilising barrier substantially consisting of superimposing a descending vertical laminar air flow and a peripherally delimited ultraviolet radiation beam also directed downwards. The device, of simplified design and small size, comprises structure for delivering a vertical laminar air flow at a controlled and humidified temperature, as well as, adjacent to such delivery structure, one or more sources for the external emission of an ultraviolet radiation beam of a wavelength appropriately chosen to offer a high germicidal action and not constitute a risk for humans. Therefore, such a substantially superimposed air flow and ultraviolet radiation beam form a barrier with high sterilising power and capable of generating confined areas. The device thus conceived is suitable for installation in circumscribed environments, typically crowded, in which the transmission of pathogens and, consequently, the risk of contagion is to be reduced. It is particularly applicable in public places such as offices, restaurants, public establishments of various kinds as well as transport.

IPC Classes  ?

• A61L 9/20 - Ultraviolet radiation

Abstract

The present invention relates to a polymeric nanoparticle having a core@shell structure comprising poly(3-hexylthiophene) in the core and poly(3-hexylthio-phene)-S,S-dioxide in the shell with critical oxidation fraction for use in ameliorating and/or treating degenerative retinal diseases.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61P 27/02 - Ophthalmic agents

Abstract

An electrochemical device with a modular stack cell structure has, at one end, a cathode plate (h1) and, at the other end, a cathode plate (h2), two electrolyte membranes (ccm), and an anode plate (2a ) between the electrolytic membranes (ccm) which are arranged in a sandwich on the sides of the anode plate (2a). The cathode plates (h1, h2) include gas collection chambers (60) connected to each other via passages (61) and connection channels (16), and communicating with the outside via a hydrogen manifold (15). The anode plate (2a) has a serpentine channel (20) closed laterally by the electrolytic membranes (ccm) and communicating with the outside via an inlet manifold (21) and an outlet manifold (22).

IPC Classes  ?

• C25B 9/77 - Assemblies comprising two or more cells of the filter-press type having diaphragms
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Goods & Services

Filters for water purifiers; Water filters for industrial purposes; Water filters; Water purifying apparatus; Membranes for the filtration of water. Filtration of liquids; Water treatment. Water analysis; Monitoring of water quality; Technical design and planning of water purification plants.

Abstract

The present invention relates to a di Cinnamomum zeylanicum EO, or to an association comprising said EO and one or more antitumour drug, for use in the treatment or in adjuvating the treatment of melanoma. The invention relates also to a pharmaceutical composition comprising said EO or said association and at least a pharmaceutically acceptable carrier for use in the treatment or in adjuvating the treatment of melanoma.

IPC Classes  ?

• A61K 36/54 - Lauraceae (Laurel family), e.g. cinnamon or sassafras
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

Described is a scintigraphic measurement device with extended area, including a measurement structure having a matrix of scintillation crystals and an optoelectronic network for converting photons into electrical signals; a collimator with collimation channels; an electronic processing unit applied to the measurement structure processing the electrical signals generated by the measurement structure. The optoelectronic network has a matrix of optoelectronic conversion modules interconnected according to a two-dimensional distribution to cover the entire measurement area, each optoelectronic conversion module including a two-dimensional matrix of individual elements “Multi Pixel Photon Counter” or individual “Silicon PhotoMultiplier” elements electrically interconnected, and wherein the optoelectronic conversion modules are electrically connected to each other along rows and columns by channels for each row or column and the electronic processing unit is connected to the optoelectronic network for measuring a total electric current of each channel delivered by the optoelectronic conversion modules positioned on the channel.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal

Abstract

A nanoparticle (1) for use in SERS spectroscopy, in particular for the detection of analytes consisting of thiolated molecules in biological fluid samples comprises a core (2) and a gold outer shell (3) between which a layer (4) of bioorthogonal Raman active molecules is interposed. The multilayer Raman active nanoparticle (1) of the invention has very low manufacturing costs and allows the indirect detection of analytes at concentrations of the picomolar order. The outer surface of the nanoparticle (1) can be engineered ad hoc to optimize the aggregation strategy as a function of the type of analyte and to detect multiple analytes in the same sample. A method for SERS spectroscopy that uses the Raman active nanoparticle (1) allows, with the same performance, to use very economical apparatuses.

IPC Classes  ?

• G01N 21/65 - Raman scattering

Abstract

The invention relates to an amorphous calcium phosphate/bioactive glass composite material (ACP/BG). This composite material possesses both the short-time ion release capability of ACP as well as the long-time ion release of BG and thus (i) efficiently remineralizes damaged enamel, and (ii) induces the formation of a new HA layer onto enamel and dentin surface. The ACP/BG composite material is obtained by embedding BG particles in a matrix of ACP nanoparticles in order to maximize homogenization between the two components and to produce a composite with high uniformity from the macro- to the nano-scale. This has been achieved with a process that includes a step of precipitating ACP onto BG particles. The BG particles can be nano-, micro-, or macro-particles. The particles can also be porous or mesoporous The invention relates also to the use of the composite material of the invention for use in the prevention of dental demineralization and to boost remineralization. In other words, the composite material here disclosed is used as remineralizing agent thanks to its ability to restore the structure and preserve the mechanical properties of dental hard tissues by releasing Ca2+and PO4 3− ions, thereby mimicking the spontaneous remineralization process induced by saliva. The composite material can also be used for bone regeneration.

IPC Classes  ?

• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products

Abstract

0maxmax ranging in between that 5 of hexaferrites (up tO ~45 kJ/m3) and rare-earth-based permanent magnets (up to ~500 kJ/m3).

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• C22C 1/04 - Making non-ferrous alloys by powder metallurgy
• C22C 1/047 - Making non-ferrous alloys by powder metallurgy comprising intermetallic compounds
• C22C 33/02 - Making ferrous alloys by powder metallurgy

Abstract

A computer implemented method for real time quantum compiling includes a unitary matrix, representing a single-qubit or multi-qubit quantum operation implemented by a quantum computer, to a machine-learning trained algorithm. Information representing a base of quantum gates for building a quantum circuit corresponding to unitary matrix operation, a tolerance parameter, and processing termination information are provided to the algorithm. A quantum circuit is determined including the combination of base quantum gates. The determining is based on a policy encoded in the algorithm by reinforced learning training. Finally, information is provided on the determined quantum circuit, as a result of the real time quantum compiling. The reinforced learning training phase is based on a Reinforced Learning procedure. The Reinforced Learning procedure includes defining an unbiased set of training target unitary matrices, defining training base sets of quantum gates, and executing episodes of the Reinforced Learning procedure.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 3/092 - Reinforcement learning

Abstract

The technology described herein is directed to compositions and methods for isolating and analyzing biological nanoparticles, e.g., extracellular vesicles.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/4995 - Pyrazines or piperazines forming part of bridged ring systems
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Described is a scintigraphic detection device with a high degree of compactness and simplified electronics, including a scintillation structure, a collimator, an optoelectronic unit associated with the scintillation structure for converting photons into electrical signals and an electronic processing unit connected to the optoelectronic unit for processing the electrical signals generated by the optoelectronic unit, wherein the optoelectronic unit includes a plurality of individual optoelectronic conversion elements of the SiPM or MPPC type each associated with a respective collimation channel and having a surface below the transversal surface of the respective collimation channel, and wherein between each optoelectronic conversion element and the scintillation structure there is an optical guide configured for conveying and for converging the photons generated by a corresponding portion of the scintillation structure towards the optoelectronic conversion element.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal

Abstract

Described is a measuring structure (100) for PET or SPECT applications comprising a matrix of scintillation crystals (200) each having a bar shape and extending along a longitudinal axis (X). Wherein the scintillation crystals (200) are parallel to each other and oriented in such a way as to define a measuring direction (R) that is transversal to the longitudinal axis (X). The measuring structure (100) comprises a first electronic conversion circuitry associated with the first surface (200a) of each scintillation crystal (200) for receiving an optical signal and converting it into an electric signal and a second electronic conversion circuitry associated with the second surface (200b) of each scintillation crystal (200) for receiving an optical signal and converting it into an electric signal. The scintillation crystals (200) are separated from each other by at least first sheets (300a) perpendicular to the measuring direction (R) and made of a metal material with a high atomic number designed to screen the incident radiations having energy that is lower than a predetermined threshold.

IPC Classes  ?

• G01T 1/164 - Scintigraphy
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

Sampling structure (1) for materials suspended in water, applicable to a vessel (2), comprising a suction pump (27) for suctioning water, a first filter (5) to retain microplastics and organic materials, and a container (12) to contain a predigesting solution (13) for the retained organic materials. The structure (1) also comprises a first and second pressure sensor (7, 17) arranged upstream and downstream of the main filter (5) respectively to measure water pressure values, and a command and control unit (10) to measure the water flow rate. The command and control unit is configured to calculate a control parameter as a function of the measured water pressure values and compare it with a predefined parameter to regulate the release of the predigesting solution.

IPC Classes  ?

• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

Abstract

Method (1) of deposition of at least one layer of at least one precursor of Perovskite on at least one substrate (4), through use of at least one deposition chamber (2), wherein the deposition chamber (2) is operatively connected to at least one vacuum pump (3); houses at least one source (5, 5′), the at least one source (5, 5′) being configured to receive at least one precursor of said Perovskite and said at least one source (5, 5′) having at least one delivery mouth (51, 51′), to let one gas of the at least one precursor of said Perovskite, when obtained into source (5, 5′), pass directly from the at least one source (5, 5′) into the at least one deposition chamber (2); and the deposition chamber (2) houses at least one supporting device (6) for the substrate (4), the supporting device (6) being configured to support said substrate (4) between at least one working position, wherein that substrate (4) is aligned with the at least one delivery mouth (51, 51′) of the at least one source (5, 5′), at a preset deposition distance (dw) therefrom, and one resting position, wherein it is spaced apart from the at least one delivery mouth (51, 51′) of the at least one source (5, 5′), at a distance greater than said preset deposition distance (dw); and wherein the at least one substrate (4) is supported in the at least one deposition chamber (2) and the at least one precursor of said Perovskite is charged into the at least one source (5, 5′) of the deposition chamber (2); the method (1) comprising the following operational steps in sequence: A. reducing pressure into the deposition chamber (2), through activation of the vacuum pump (3), until one pressure value (P r) comprised within a preset operational pressure interval (ΔPc) is obtained; B. sublimating the at least one precursor in the at least one source (5, 5′), until one gas of the at least one precursor is obtained; C. if not yet in the working position, bringing the substrate (4) at the working position and the substrate (4) to one preset working temperature (Tw); D. depositing the at least one gas of the at least one precursor thereby sublimated, on said substrate (4); and E. cooling the at least one source (5, 5′); wherein the preset operational pressure interval is between 0.1×10−3 mbar and 100×10−3 mbar, optionally between 1×10−3 mbar and 5×10−2 mbar, more optionally between 2×10−2 mbar and 4×10−2 mbar and wherein the preset deposition distance (dw) is between 0.5 cm and 5 cm, optionally between 1 cm and 3 cm, more optionally comprised between 1.5 cm and 2.5 cm.

IPC Classes  ?

• C30B 25/16 - Controlling or regulating
• C30B 25/10 - Heating of the reaction chamber or the substrate
• C30B 25/14 - Feed and outlet means for the gasesModifying the flow of the reactive gases
• C30B 29/22 - Complex oxides

Abstract

A device for transforming between an azimuthal phase and a linear phase in a charged particle beam A device for transforming between an azimuthal phase and a linear phase in a charged particle beam (10), the device comprising a first phase changing element (S1) and a second phase changing element (S2) arranged along a beam axis (20) at conjugate Fourier planes of a lens system (L1). The first phase changing element (S1) comprises a planar electrostatic arrangement of needle-shaped electrodes arranged orthogonally to the beam axis (20), the electrostatic arrangement comprising a first needle-shaped electrode (41) and a pair of second needle-shaped electrodes (42) arranged on opposite sides of, and oriented orthogonally to, the first needle-shaped electrode (41). The electrostatic arrangement further comprises a third needle-shaped electrode (43) and a pair of fourth needle-shaped electrodes (44) arranged mirror-wise with respect to the first needle-shaped electrode (41) and second needle- shaped electrodes (42), about a symmetry plane (M) arranged orthogonally to the first needle-shaped electrode (41).

IPC Classes  ?

• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes
• H01J 37/153 - Electron-optical or ion-optical arrangements for the correction of image defects, e.g. stigmators
• G21K 1/16 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using polarising devices, e.g. for obtaining a polarised ion beam

Abstract

Silicon photonic crystal (10; 10'; 10") comprising periodic silicon structures (12) contiguous with voids (14), and a silicon resonant cavity (16) consisting of silicon nanowires (18) entirely made of silicon with uniform doping, said nanowires acting as active medium of the photonic crystal.

IPC Classes  ?

• H01S 5/02 - Structural details or components not essential to laser action
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
• H01S 5/10 - Construction or shape of the optical resonator
• H01S 5/11 - Comprising a photonic bandgap structure
• H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers

Abstract

It is disclosed a system and method for adjusting the alignment of a light sheet microscope. A beam splitter intercepts a fraction of light emitted by a slice of a sample illuminated by the light sheet. The intercepted light fraction is focused to form two bidimensional images on a photodetector, each bidimensional image being formed by rays coming from a respective portion of an exit pupil of the microscope's objective. At least two pairs of corresponding areas are identified in the two bidimensional images, and a mutual distance between corresponding areas of each pair is determined. A misalignment parameter indicative of a misalignment of the light sheet relative to a focal plane of the microscope's objective is then calculated, based on the determined mutual distances of the various pairs of corresponding areas. An adjustment command is then generated based on the misalignment parameter.

IPC Classes  ?

• G02B 21/24 - Base structure
• G02B 21/00 - Microscopes

Abstract

It is disclosed a system and method for multicolor light sheet microscopy, wherein at least two substantially parallel light beams having different wavelengths illuminate at least two corresponding strips of a sample. The at least two substantially parallel light beams are translated over time along a scanning direction, while keeping them at a non-null reciprocal distance YO along the scanning direction. The light emitted by the illuminated strips of the sample is split into at least two light portions following respective detection paths. Along each detection path, the corresponding light portion is subjected to a spatial filtering which isolates a light line emitted by one the illuminated strips of the sample. Such light line is finally detected by a photodetector.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure. The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

IPC Classes  ?

• C07C 37/11 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07D 311/80 - DibenzopyransHydrogenated dibenzopyrans

Abstract

33 -anions and Ag+cations, and said Ag+ cations then precipitate on the silicon wafer, thus resulting in the formation of multiple silver dendrites (25). The method further comprises the step of separating the silver dendrites from the silicon wafer thus obtaining a layer of isolated silver dendrites.

IPC Classes  ?

• A61F 2/30 - Joints
• A61F 2/34 - Acetabular cups
• A61F 2/36 - Femoral heads
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

The object of the invention is a method for extracting, with high yield, phycobiliproteins from cyanobacterial and/or algal biomass, obtaining extracts in water or aqueous solutions characterised by high pigment concentration and a purity degree equal to or greater than the food/cosmetic grade (P≥2). The method is based on a process characterised by a step of breaking down the cyanobacterial/algal cells by ultrasonication in an aqueous solution of ammonium sulphate, and simultaneous extraction of water-soluble compounds other than phycobiliproteins, followed by an extraction step of the phycobiliproteins using water or aqueous solutions.

IPC Classes  ?

• C07K 1/14 - ExtractionSeparationPurification
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/405 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from algae

Abstract

An epigenetic silencer factor (ESF) comprising a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/10 - Transferases (2.)

Abstract

The present invention relates to a wind apparatus to maximize the amount of kinetic energy associated with an air flow captured over time by said wind apparatus. The present invention relates to a wind apparatus to maximize the amount of kinetic energy associated with an air flow captured over time by said wind apparatus. In particular, said wind apparatus comprises at least one wind system, wherein said wind system comprises at least one a bladed device provided with one or more blades and configured to be electronically controlled so that its aerodynamic behaviour changes over time based on the action exerted by said air flow on said one or more blades of said bladed device.

IPC Classes  ?

• F03D 15/00 - Transmission of mechanical power
• F03D 9/25 - Wind motors characterised by the driven apparatus the apparatus being an electrical generator
• H02K 7/18 - Structural association of electric generators with mechanical driving motors, e.g.with turbines

Abstract

The present invention provides compositions and methods for treating cancer in a human. The invention includes a chimeric receptor which comprises an CD64 binding domain, a transmembrane domain, and a CD3zeta signaling domain.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• C07K 14/735 - Fc receptors
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

Plant (1) and process for in situ decontamination of soil and/ or groundwater from organic and inorganic contaminants. The plant (1) comprises an extraction section (10) for extracting a predetermined flow-rate of groundwater to be decontaminated is sent to a pre- treatment section (20) where one or more primary sedimentation devices (25) are arranged. The pre- treated aqueous solution is, then, sent to a physical- chemical treatment section (30) where is subjected to a series of reactions in one or more reaction tanks (35) where the precipitation of determined contaminants is caused. A second sedimentation follows in a secondary sedimentation device (39) to physically separate the precipitated contaminants from an aqueous solution and to separate the same by filtration. The filtered aqueous solution is, then, enriched in an enrichment section (40) by adding selected chemical reagents and biological solutions and a flow-rate of oxygen modulated according to a conceptual multidimensional model designed on the basis of soil and groundwater preliminary characterization. The enriched aqueous solution is, then, injected into the subsoil at an injection section (50).

IPC Classes  ?

• B09C 1/00 - Reclamation of contaminated soil
• B09C 1/08 - Reclamation of contaminated soil chemically
• B09C 1/10 - Reclamation of contaminated soil microbiologically or by using enzymes
• C02F 1/40 - Devices for separating or removing fatty or oily substances or similar floating material
• C02F 1/00 - Treatment of water, waste water, or sewage
• C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
• C02F 9/00 - Multistage treatment of water, waste water or sewage
• B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
• C02F 103/06 - Contaminated groundwater or leachate

Abstract

Described is a measuring structure (100) for PET or SPECT applications comprising a matrix of scintillation crystals (200) configured for simultaneously measuring radiation directed along respective directions, each crystal (200) extending along a longitudinal axis (X) between an upper surface (200a) and a base surface (200b) opposite the upper surface (200a), each scintillation crystal (200) having, along the longitudinal axis (X), a variable transversal section. The structure also comprises a grille (300) defining a plurality of through seats each configured for receiving a respective scintillation crystal (200). Each seat has inner walls (301) shaped to match a lateral surface of the respective scintillation crystal (200). The grille (300) is made of a metal material with a high atomic number designed to screen incident radiation.

IPC Classes  ?

• G01T 1/164 - Scintigraphy
• G01T 1/202 - Measuring radiation intensity with scintillation detectors the detector being a crystal
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science; Chemical substances, chemical materials and chemical preparations, and natural elements; Reagents for research purposes; Reagents for scientific or medical research use; chemicals for use in scientific analysis. Ores, common metals and their alloys. Business management software; Business process management [BPM] software; Document management software; Content management software; Data and file management and database software; Research apparatus and instruments; Computer software to enable the searching of data; Dissecting instruments for scientific or research purposes; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; Databases; Databases (electronic); Interactive databases; Simulation software; Temperature sensitive testing apparatus for scientific use; Artificial intelligence software for analysis; Testing probes, other than for medical purposes. Telecommunications services; Providing user access to search engines; Providing access to databases; Communication services between data banks; Providing telecommunications connections to the internet or databases; Transmission of database information via telecommunications networks. Material treatment information; Processing of chemicals; Heat treatment of ores; Treatment and processing of ores and ore concentrates; Metal treating; Treatment of materials using chemicals. Teaching and Training in relation to the following fields: Science; Organisation of seminars, Organisation of conventions, Organisation of courses and organization of workshops; Training in the operation of software systems; Training for handling scientific instruments and apparatus for research in laboratories; Training courses relating to database designs; Publication of material which can be accessed from databases or from the internet; Technical training relating to chemical analysis. Science and technology services; Research and design services; Industrial analysis, industrial research and industrial design services; Quality control and authentication services; Design and development of computer hardware and software; Platform as a service [PaaS]; Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; Design of information technology infrastructure for others; Consultancy in the field of scientific research; Consultancy services relating to technological research; Providing online information about industrial analysis and research services; Provision of research services; Technical research projects and studies; Preparation of technological research reports; Research laboratories; Provision of information relating to scientific research; Research and development of new products; Research and development of computer software; Scientific research and development; Design of computer databases; Providing scientific research information and results from an online searchable database; Providing temporary use of on-line non-downloadable software for database management; Installation of database software; Research in the field of nanobiotechnology; Development of new technology for others; Research in the field of quantum simulation; Development of computer programs for simulating laboratory experiments; Environmental testing; Chemical analysis; Chemical analysis services for use in evaluation; Analysis of materials; Testing of raw materials; Analysis of product design; Industrial testing; Materials testing and analysing; Providing information about industrial analysis and research services.

Abstract

The present invention refers to polymeric reverse micelles for delivery of hydrophilic macromolecules. In particular, it relates to a polymeric reverse micelle for the delivery of an active pharmaceutical ingredient, wherein the interior of the reverse micelle is hydrophilic and is suitable to contain a water-soluble active pharmaceutical ingredient and the exterior of the reverse micelle is hydrophobic, wherein said reverse micelle comprises at least two polymers, each one having the formula (I) disclosed in the description. A process to obtain such reverse micelle is also an object of the invention such as pharmaceutical compositions comprising the micelle.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

An epigenetic silencer factor (ESP), or polynucleotide encoding therefor, for use in the treatment of cancer, wherein the ESF comprises a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor, wherein the cancer is selected from the group consisting of: glioma, gliobastoma, medulloblastoma, astrocytoma, neuroblastomas, ependymoma, meningioma, retinoblastoma, rhabdomyosarcoma, lung cancer, prostate cancer, breast cancer, liver cancer, pancreatic cancer (e.g. human pancreatic ductal adenocarcinoma), bladder cancer, oropharyngeal cancer, kidney cancer, colon cancer (e.g. colon adenocarcinoma), colon-rectal cancer (CRC), or a metastasis of any of the foregoing.

IPC Classes  ?

• C07K 14/34 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Corynebacterium (G)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/67 - General methods for enhancing the expression
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 9/10 - Transferases (2.)

Abstract

A computer-implemented method for determining a fetus ventricular volume from DWI images is provided. The computer-implemented method involves acquiring DWI images, with a pre-set voxel height, of a fetus ventricle, the acquisition being made with a single b-value selected in a range between 200 and 1000 s/mm2, selecting a ROI on each of the DWI images around the fetus ventricle, automatically clusterizing pixels in the ROI, obtaining clusterized DWI images, and calculating the fetus ventricular volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. An NMR assessment system and an NMR assessment method implementing the method for determining the fetus ventricular volume are also provided.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

Abstract

A polynucleotide comprising at least one miR-124 target sequence, and/or at least one miR- 338-3p target sequence, and/or at least one miR-31 target sequence, wherein the miRNA target sequences are operably linked to a transgene.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors

Abstract

The present description concerns a photovoltaic module (1) and the method for installing the same. The photovoltaic module (1) comprises a light trapping optical concentrator (2). A first dichroic mirror (41) covers the bottom surface (22) of the concentrator (2), and is configured to transmit light in a first band, and to reflect light in a second band. A first photovoltaic cell (31) covers the first dichroic mirror (41) and is configured to generate electric power by conversion of light in the first band. A second photovoltaic cell (32) covers the rear surface (23) of the concentrator (2), preferably with a second dichroic mirror (42), and is configured to generate electric power by conversion of light in the second band. Characteristic of the photovoltaic module (1) is a wedge angle α selected for light in the second band to be guided by total internal reflection with a low concentrating ratio on the second photovoltaic cell (32) without the need of tilt sun tracking.

IPC Classes  ?

• H01L 31/054 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means
• H01L 31/049 - Protective back sheets
• G02B 19/00 - Condensers

Abstract

Apparatus (50) for absorbing microwaves in the form of high-frequency, high-power microwave beams (100), wherein said apparatus (50) comprises a load (20) and a microwave beam (100) deflection device (10), wherein said load (20) is a bolometric device with a receiving cavity and comprises a hollow body (21) having a receiving cavity comprising an opening (25) for the entry of an incident microwave beam (100) into the receiving cavity, a scattering element (23) suitable for reflecting a multiplicity of components of said microwave beam (100) incident towards a multiplicity of angles of reflection by directing a multiplicity of components of reflected microwave beam (100) towards an internal surface (22) of the cavity, wherein said deflection device (10) comprises a body comprising a cavity, a first opening (15) of the cavity connected with said opening (25) of the cavity of the load (20) and a second opening (16) of the cavity connected with transmission lines (30) of the microwave beam (100) adapted to transport the microwave beams (100) from a source to the deflection device (10), wherein said cavity of said deflection device (10) comprises within itself at least two converging mirrors (11, 12), wherein said at least two converging mirrors (11, 12) are a first converging mirror (11) adapted to intercept the incident microwave beam (100) exiting the transmission line (30), and a second converging mirror (12) adapted to intercept the incident microwave beam (100) by deflecting it towards the opening (25) of the load (10).

IPC Classes  ?

• H01P 1/26 - Dissipative terminations
• G01K 17/00 - Measuring quantity of heat
• H05B 6/64 - Heating using microwaves

Abstract

A process (100) for manufacturing a patch (10) to be applied on a human or animal organ, comprising the steps of: preparing a bio-polymeric ink (200); providing a substrate at least partially made by said bio-polymeric ink (300); printing a circuit on said substrate (400).

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/268 - Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
• A61B 5/257 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
• C09D 11/04 - Printing inks based on proteins
• C09D 11/52 - Electrically conductive inks
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/015 - Cylindrical cells
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 9/63 - Holders for electrodesPositioning of the electrodes
• C25B 9/65 - Means for supplying currentElectrode connectionsElectric inter-cell connections
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

Abstract

Perovskite-based photovoltaic cell (or solar cell) wherein the perovskite photoactive layer comprises at least one partially neutralized polyacrylic acid in an amount greater than or equal to 3% by weight, preferably comprised between 4% by weight and 15% by weight, more preferably comprised between 4.5% by weight and 12% by weight, with respect to the total weight of the perovskite precursors. Said perovskite-based photovoltaic cell (or solar cell) can be advantageously used in various applications which require the production of electricity through the exploitation of light energy, in particular of solar radiation energy such as, for example: architecturally integrated photovoltaic systems (Building Integrated Photo Voltaic - BIPV); photovoltaic windows; greenhouses; photo-bioreactors; noise barriers; lighting engineering; design; advertising; automobile industry. Said perovskite-based photovoltaic cell (or solar cell) can be used both in stand-alone mode and in modular systems.

IPC Classes  ?

• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 30/20 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising organic-organic junctions, e.g. donor-acceptor junctions

Abstract

This invention relates to a powder composition for inhalation use comprising a plurality of microparticles comprising at least one water-soluble pharmaceutically acceptable carrier embedding at least one nanoparticle of calcium phosphate for the delivery of therapeutic/diagnostic compounds.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention concerns an extract from pomegranate (Punica granatum L), specifically obtained from one or more immature pomegranate fruits. This extract is obtained through an extraction process including steps a)-d) as described in the text and it may contain gallotannins, ellagitannins, ellagic acid derivatives and granatins. Pharmaceutical and nutraceutical compositions and food supplements comprising this extract fall within the scope of the present invention as well as their use in various fields, more specifically for the treatment of tumors.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 31/365 - Lactones
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61P 35/00 - Antineoplastic agents
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A method for controlling an electron beam with a phase modulator (20), the phase modulator comprising input contacts (22) configured to receive input signals, and an array of MEMS devices (23) for controlling an electron beam (EB), each MEMS device comprising a MEMS electrodes (24) operable to control the electron beam based on the input signals, wherein the method comprises sending to an individual input contact (22) a respective multiplexed input signal formed by a plurality of superimposed AC signals at different frequencies, demultiplexing the multiplexed input signal to a plurality of frequency channels (25) respectively associated to the MEMS electrodes (24), and rectifying and DC-converting the demultiplexed input signal in such a way that each MEMS electrode (24) is biased with a DC signal corresponding to the amplitude of one of the AC signals.

IPC Classes  ?

• H01J 37/04 - Arrangements of electrodes and associated parts for generating or controlling the discharge, e.g. electron-optical arrangement, ion-optical arrangement
• H01J 37/26 - Electron or ion microscopesElectron- or ion-diffraction tubes

Abstract

Described herein is an optoelectronic device comprising : a substrate; an active layer made from at least one perovskite microwire having a longitudinal extension and having a first surface in contact with said substrate; a first electrode deposited on said substrate; a second electrode made of electrically conductive material and comprising a central tract, deposited in contact with a second surface of said at least one microwire, said second surface being opposite to said first surface.

IPC Classes  ?

• H10K 39/30 - Devices controlled by radiation
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

A monitoring device of biological cells including: a fluidic channel in which a fluid including biological cells is made to flow, including a first and second glass walls placed in parallel and a reflective surface adjoined to the second wall; and a piezoelectric transducer, the piezoelectric transducer emitting acoustic waves creating a force acting on the biological cells, making them flow substantially along a single motion plane. The external interface between the first wall and the exterior of the fluidic channel and the reflective surface are configured to function as a Fabry-Perot interferometer, such that the motion planes sensibly perpendicular to the optical axis of the Fabry-Perot interferometer. The finesse of the interferometer is lower than 10. The monitoring device further includes a detecting unit detecting a fringe pattern stemming from the Fabry-Perot interferometer and an analysing device, analysing the fringe pattern and configured to output data on physical properties of the cells based on the pattern.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry

Abstract

An implantable platform for imaging in-vivo comprising: a planar substrate (10) transparent to light; at least one three-dimensional matrix (12) fabricated on a side of said planar substrate (10), configured to host biomaterial; wherein said at least one three-dimensional matrix (12) is obtained by means of two-photon photo-polymerisation and is luminescent under infrared excitation by two-photon absorption; at least one micro-optical device (11), comprising at least one lens (20, 21, 22), fabricated by means of two-photon photo-polymerisation or nanoimprinting lithography on the other side of said planar substrate (10) placed in correspondence of said a least one three-dimensional matrix (12); wherein said implantable platform for imaging in-vivo is configured to be implantable below the skin of a laboratory animal.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A device (1) for the bilateral rehabilitation of a user's limbs, comprising a main body (5) connected to a connecting base (2), a first motor (7') and a second motor (7'') supported by the main body (5), a first rotary interface (8') and a second rotary interface (8'') supported by the main body (5) rotatably operable about first and second rotation axes (15', 15'') by the motors (7', 7''), grip accessories (12.1, 12.2,..., 12.n) having a grip portion (13) and a coupling portion (14) couplable to the first (8') and second (8'') rotary interfaces, an electronic control device (11) configured to control the rotary movements and the torques applied to the first (8') and second (8'') rotary interfaces depending on angular positions or torques detected by position detecting means (9', 9'') or torque detecting means (10', 10''), wherein the main body (5) is connected to the connecting base (2) by means of an adjustable and lockable joint (6) which allows an adjustment and locking of the position of the main body (5) with respect to the connecting base (2) in at least three different body positions with different orientations of the first (15') and second (15'') rotation axes.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising
• A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
• A63B 22/00 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements
• A63B 23/035 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously
• A63B 71/00 - Games or sports accessories not covered in groups
• A63B 21/16 - Supports for anchoring force-resisters
• A63B 23/12 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously for upper limbs

Abstract

The invention concerns nanovesicles of nanostructured myelin and uses thereof in the treatment of demyelinating and neurodegenerative diseases of the central (CNS) and peripheral (PNS) nervous system. Under another aspect, processes for the preparation of myelin nanovesicles having particular characteristics that make them suitable for recovery of the myelin sheath, where it is compromised, as a drug delivery system for CNS or PNS, and for immunotolerance, are described.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

An adeno-associated viral (AAV) capsid protein, wherein the capsid protein comprises: (a) a peptide comprising or consisting of the amino acid sequence PGVPGRF, or a variant thereof having up to two amino acid substitutions, additions or deletions; or (b) a peptide comprising or consisting of the amino acid sequence NGVRSVG, or a variant thereof having up to two amino acid substitutions, additions or deletions.

IPC Classes  ?

• C07K 14/075 - Adenoviridae

Abstract

An adeno-associated viral (AAV) capsid protein, wherein the capsid protein comprises: (a) a peptide comprising or consisting of the amino acid sequence PGVPGRF, or a variant thereof having up to two amino acid substitutions, additions or deletions; or (b) a peptide comprising or consisting of the amino acid sequence NGVRSVG, or a variant thereof having up to two amino acid substitutions, additions or deletions.

IPC Classes  ?

• C07K 14/075 - Adenoviridae

Abstract

The invention relates to a composition of lipid vesicles, preferably extracellular vesicles (EVs), displaying the protein Cripto on their surface, for use in the therapeutic treatment of a primary tumour or in the therapeutic or preventive treatment of tumour metastases, such as for example glioblastoma or glioblastoma metastases.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61P 35/04 - Antineoplastic agents specific for metastasis
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/485 - Epidermal growth factor [EGF], i.e. urogastrone

Abstract

Superconducting interferometer (20) comprising two SQUIPTs (100, 200), each comprising a superconducting loops (24a, 24b), placed in parallel between a first terminal (22) arranged to be connected to a ground voltage and two metal tunnel probes (26a, 26b), the interferometer (20) being arranged to be placed into a magnetic flux (Φ) and a first current (I1) and a second current (I2) flowing through a first Josephson junction (28a) and a second Josephson junction (28b) placed into a respective loops (24a, 24b), thus producing a respective voltage drop (V1, V2) at each tunnel probe (26a, 26b), wherein the interferometer (20) is arranged to generate an output voltage (Vout) as a function of said voltage drops (V1, V2), said output voltage (Vout) being a linear function of the magnetic flux (Φ) given a predetermined additional component (Δφ) of the magnetic flux (Φ) introduced into one of the two loops (24a, 24b).

IPC Classes  ?

• G01R 33/035 - Measuring direction or magnitude of magnetic fields or magnetic flux using superconductive devices

Abstract

A multifunction gamma radiation detector includes a supporting rod, a detection head coupled to or integrated with a first end of the supporting rod including detection elements separate from each other for simultaneously detecting gamma radiation directed along respective directions. Each detection element includes a scintillation crystal and corresponding first electronic conversion circuitry for receiving an optical signal from the crystal and converting it into an electrical signal. The detector also includes a handgrip, connectable to a second end of the supporting rod and which can be manually gripped by an operator to direct the detector, and a second electronic circuitry for converting and/or treating the signals connected to the first electronic conversion circuitry. The head also includes an optical detection device acquiring a sequence of optical signals emitted by a suitably energized body tissue. The detection elements are angularly distributed on the detection head about optical detection device.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G01T 1/164 - Scintigraphy

Abstract

It is disclosed a device for multipole phase division multiplexing and demultiplexing and a spatial division telecommunications system comprising the multiplexing and demultiplexing devices. The multipole phase demultiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a circular-sector transformation of a plurality of multipole phase electromagnetic beams. The multipole phase multiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a combination of |m | circular-sector transformations of a plurality of tilted electromagnetic beams.

IPC Classes  ?

• H04B 10/2581 - Multimode transmission
• H04J 14/04 - Mode multiplex systems

Abstract

A microfluidic patch for separating specific species in biological fluids, comprising a flow layer comprising: a first porous portion to receive and carry a starting biological fluid containing related species; a multilayer membrane downstream the first porous portion and comprising a plurality of graphene-based sheets spaced among each other to define a plurality of parallel channels transversally interconnected and chemically functionalized to provide from the starting biological fluid an outgoing flow of specific species to be detected; and a second porous portion placed downstream the multilayer membrane to receive and carry the outgoing flow to be detected; the patch comprises a first upstream electrode and a first downstream electrode placed respectively upstream and downstream the multilayer membrane to foster the flow through the multilayer membrane from the first to the second porous portion.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive

Abstract

Provided is an atomic vapor cell, for atomic or molecular spectroscopy, optical pumping, and/or spin-based atomic sensing, that includes a host substrate and defined there within a buried or non-buried chamber laser written in the host substrate without the need of a mask or photoresist, with either planar or three-dimensional geometry, and intended to contain an atomic vapor. Also provided are an integrated atomic/photonic device and an apparatus, in both cases including the presently disclosed atomic vapor cell, and a method for fabricating the presently disclosed atomic vapor cell.

IPC Classes  ?

• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
• G01R 33/46 - NMR spectroscopy

Abstract

A patterned light generating device (100, 300) for microscopy comprising: at least a first optical waveguide (1) and a second optical waveguide (2), the waveguides (1, 2) being configured for transmitting a polarized light beam to their ends; at least one coupler (12) for splitting a laser beam entering the device (100, 300) between the first waveguide (1) and the second waveguide (2); a substrate (7), preferably of glass, having one input port and at least a first output port and a second output port, said substrate (7) being configured for housing the waveguides (1, 2) and the at least one coupler (12); an input polarization maintaining fibre (10) fixed at the input port and configured for coupling the laser beam into the first waveguide (1); and at least a first output polarization maintaining fibre (21) fixed at the first output port and configured for being coupled with the first waveguide (1) in such a way to transmit a light beam from the first waveguide to an end of the first output polarization maintaining fibre (21) and a second output polarization maintaining fibre (22) fixed at the second output port and configured for being coupled with the second waveguide (2) in such a way to transmit a light beam from the second waveguide to an end of the second output polarization maintaining fibre (22); at least one phase shifter (11) configured for creating a phase difference between the first waveguide (1) and the second waveguide (2), the phase shifter (11) being housed in the substrate (7); and a glass ferrule (30) configured to being coupled with the output polarization fibres (21, 22), the output polarization fibres (21, 22) ending into the ferrule (30) in such a way to be oriented one respect to the other by an angle equal to the round angle divided by the number of waveguides (1, 2).

IPC Classes  ?

• G02B 21/00 - Microscopes
• G02B 21/06 - Means for illuminating specimen
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

A geopolymeric material is described having compressive strength at 28 days ranging from 15 to 100 N/mm2, obtainable by curing for 12 hours at a temperature ranging from 20° C. to 60° C., from a geopolymeric aqueous mixture comprising the following inorganic components in the following parts by dry mass: metakaolin 1565 potassium silicate and/or sodium silicate 2040 aggregates recycled from CDW (Construction and Demolition Waste) 5300; said geopolymeric aqueous mixture is obtainable by mixing 20175 parts by mass of water with said inorganic components, and has a viscosity at 23° C. between 100 and 10000 Pa·s, wherein: i) the viscosity is measured via Brookfield methodology, ii) the aggregates recycled from CDW belong to one or more of the classes 17.01.01, 17.01.02, 17.01.03, 17.01.07 according to the European Waste Catalogue, iii) the aggregates recycled from CDW have a grain size less than or equal to 4 mm, preferably less than or equal to 2 mm.

IPC Classes  ?

• C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
• C04B 14/10 - Clay
• C04B 18/167 - Recycled materials, i.e. waste materials reused in the production of the same materials
• C04B 18/06 - Combustion residues, e.g. purification products of smoke, fumes or exhaust gases
• C04B 18/08 - Flue dust
• E04F 13/08 - Coverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements
• E04F 13/14 - Coverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of stone or stone-like materials, e.g. ceramicsCoverings or linings, e.g. for walls or ceilings composed of covering or lining elementsSub-structures thereforFastening means therefor composed of a plurality of similar covering or lining elements of glass
• F24D 3/12 - Tube and panel arrangements for ceiling, wall, or underfloor heating

Abstract

A process for the synthesis of nanocrystals of metal chalcohalides is disclosed, where M is a metal, E is a chalcogen and X is a halogen, starting from a salt of M. The process includes the following steps: a) a precursor of metal M is mixed with a surfactant in a solvent having a boiling point higher than 180 °C; b) the mixture obtained in previous step a) is heated, in order to dissolve the components, until it becomes clear; c) the solution is heated up under inert atmosphere at the desired temperature; d) chalcogen and halogen precursors in 0 a solvent having a boiling point higher than 180 °C are added through injection, while heating the solution obtained in steps a) to c); e) after the reaction time has elapsed, the product is quenched down to room temperature.

IPC Classes  ?

• C01G 29/00 - Compounds of bismuth
• C01B 19/00 - SeleniumTelluriumCompounds thereof
• C01G 30/00 - Compounds of antimony
• C09D 11/00 - Inks

Goods & Services

Academies [education]; Teaching; Teaching; Production of shows; Arranging and conducting of conferences; Arranging and conducting of congresses; Organization of exhibitions for cultural or educational purposes; Vocational guidance [education or training advice]; Conducting guided tours; Arranging of exhibitions for training purposes; Arranging of displays for training purposes; Organizing and arranging exhibitions for entertainment purposes; Organisation of conferences, exhibitions and competitions.

Goods & Services

Academies [education]; Teaching; Teaching; Production of shows; Arranging and conducting of conferences; Arranging and conducting of congresses; Organization of exhibitions for cultural or educational purposes; Vocational guidance [education or training advice]; Conducting guided tours; Arranging of exhibitions for training purposes; Arranging of displays for training purposes; Organizing and arranging exhibitions for entertainment purposes; Organisation of conferences, exhibitions and competitions.

Goods & Services

Teaching; Training; Entertainment services; Sporting and cultural activities; Teaching, Organisation of seminars, Publication of.

Abstract

The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The invention concerns a compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: (I) wherein R represents a 6-membered aryl or heteroaryl group or a 5-membered heteroaryl group, optionally substituted with at least one halogen atom, for use as a medicament. The invention also concerns a pharmaceutical composition comprising, as active ingredient, at least one compound of formula (I), as above, or pharmaceutically acceptable salts or hydrates thereof, and at least one pharmaceutically acceptable excipient, and the pharmaceutical composition for use as a medicament. The invention also concerns such compound or pharmaceutical composition for use as HSP90 inhibitor, in selectively killing senescent cells, in delaying ageing in a subject and in the treatment and/ or prevention of a senescence -associated disease or disorder. The invention also concerns a method for preparing such compound. The invention also concerns the cosmetic use of the compounds of formula (I) or cosmetically acceptable salts or hydrates thereof, and of a cosmetic composition that comprises at least one such compound.

IPC Classes  ?

• C07C 307/00 - Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
• A61K 31/15 - Oximes (C=N—O—)Hydrazines (N—N)Hydrazones (N—N=)
• A61K 8/00 - Cosmetics or similar toiletry preparations
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 17/00 - Drugs for dermatological disorders
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 27/02 - Ophthalmic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/12 - Antivirals
• A61P 35/00 - Antineoplastic agents
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07C 305/00 - Esters of sulfuric acids
• C07D 203/24 - Sulfur atoms

Abstract

2516n21616162781-6161-616788 and the nitrogen to which they are attached form a 5 or • 6 membered heterocyclic ring (such as morpholine or piperidine); and • - n represents 0-2; for use as a medicament, in particular as HSP90 inhibitor, in selectively killing senescent cells, in delaying ageing in a subject and in the treatment and/or prevention of a senescence-associated disease or disorder.

IPC Classes  ?

• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 17/00 - Drugs for dermatological disorders
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 27/02 - Ophthalmic agents
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 473/04 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
• C07D 473/06 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
• A61Q 19/08 - Anti-ageing preparations
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds

Abstract

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

IPC Classes  ?

• A61K 38/53 - Ligases (6)
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

iniiiiiii of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2ninput encoding model, wherein the number of qubits n of the initial first quantum state is such that 2nininin corresponds to the input vector dimension; - applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; - by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; - processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d-1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); - by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2,..., zd) encoded; - processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function f, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; - encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A quantum computation system for performing quantum calculations in a quantum neural network and a quantum computation system for implementing a quantum neural network are also described.

IPC Classes  ?

• G06N 3/048 - Activation functions
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

IPC Classes  ?

• A61K 38/53 - Ligases (6)
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

A photoacoustic sensor for spectroscopic gas detection, comprising a chamber adapted to contain the gas to be analysed, an excitation laser source adapted to emit a modulated laser beam, which is absorbed by the gas present in the chamber and creating a pressure wave, a transducer, the transducer being located inside the chamber, and being adapted to be put into oscillations by the pressure wave, the transducer having a reflective portion, an interferometer having a first and a second arm and an output able to detect the oscillations of the transducer, with the first arm ending in the transducer, and the second arm including an optical path changer element and an actuator connected to the optical path changer element to change the optical path defined by the second arm of the interferometer, a first polarizing beam splitter, a second laser source for interferometer reading, adapted to emit a second laser beam impinging onto the first polarizing beam splitter, the first polarizing beam splitter being adapted to split the second laser beam in the first and the second arm of the interferometer, so that the split beam travelling in the first arm is back- reflected by the reflective portion of the transducer, and the split beam travelling in the second arm is back-reflected by the optical path changer element, so that the resulting back-reflected split beams interfere in the interferometer, a second polarizing beam splitter adapted to split the interfering light at the output of the interferometer in two beams which are orthogonally polarized, a first detector adapted to detect one of the two orthogonally polarized beam exiting the interferometer and to generate a corresponding first electric signal, a second detector adapted to detect the other of the two orthogonally polarized beam exiting the interferometer and to generate a corresponding second electric signal, an electronic circuit configured to obtain a difference signal, the difference signal being function of the difference between the signal generated by the first detector and the signal generated by the second detector, and a feedback loop adapted to command the movements of the actuator in order to change and stabilize the optical path of the second arm, so that the difference signal is kept equal to a desired constant value during the gas concentration measurements.

IPC Classes  ?

• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 29/24 - Probes

Abstract

bLLbLLL-)corresponding to respective stable logic states (0, 1) stored by the memory (1) resetting the bias current to zero.

IPC Classes  ?

• G11C 11/44 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using super-conductive elements, e.g. cryotron
• H10N 10/00 - Thermoelectric devices comprising a junction of dissimilar materials, i.e. devices exhibiting Seebeck or Peltier effects
• H10N 60/00 - Superconducting devices

Abstract

Provided are methods of transducing hair cells of the inner ear in a subject comprising administering to the subject an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a capsid comprising the amino acid sequence of SEQ ID NO: 1, wherein the AAV vector further comprises a heterologous nucleic acid sequence. Additionally, methods of treating, preventing, or inhibiting a cochlear disorder or balance disorder in a subject comprising administering the AAV vector to the subject are provided.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 27/16 - Otologicals
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca