Abrégé

A computer implemented method for performing quantum calculations in a quantum neural network is described. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A computer implemented method for performing quantum calculations in a quantum neural network is described. The neural network considered in this method comprises at least one input layer comprising a first number Nin of input layer neurons adapted to receive respective input values xi belonging to an input vector x. Each input layer neuron is configured to multiply the respective input value xi by a respective weight value wi belonging to a weight vector w. The aforesaid neural network further comprises at least one calculation neuron, operatively connected to the aforesaid input layer, and configured to provide a computation result y=f(z) calculated by applying an activation function ƒ to an argument z. Such an argument z is a scalar number calculated by the calculation neuron as the sum of the products of the input values xi by the respective weights wi plus a bias value b. The method comprises the following steps: encoding, by a first quantum process, the input values xi of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2n input encoding model, wherein the number of qubits n of the initial first quantum state is such that 2n is greater or equal to a second number equal to Nin+3, where Nin corresponds to the input vector dimension; applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d−1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2, . . . ,zd) encoded; processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function ƒ, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A quantum computation system for performing quantum calculations in a quantum neural network and a quantum computation system for implementing a quantum neural network are also described.

Classes IPC  ?

• G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels

Abrégé

The present invention concerns an apparatus (1) for inducing and/or controlling the flow of a fluid in a microfluidic circuit (200) of a microfluidic device (100) comprising a pumping station (15), comprising a pumping liquid (15') and a pad (5), configured to absorb said pumping liquid (15') present in said pumping station (15), said pad (5) being so adapted to induce a flow of a fluid present in a microfluidic circuit (200) in fluid communication with said pumping station (15), wherein said pad (5) has a three-dimensional shape, adapted to define a three-dimensional absorption volume, partially insertable into, and removable from, said pumping station (15) to induce and/or control the flow of said fluid.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

A photoacoustic sensor for spectroscopic gas detection includes a chamber to contain the gas; an excitation laser source that emits a modulated laser beam; a transducer, having a reflective portion, located inside the chamber; an interferometer having first and second arms and an output, the first arm ending in the transducer, and the second arm including an optical path changer element and an actuator connected to the optical path changer element to change the optical path defined by the second arm of the interferometer; a first polarizing beam splitter; a second laser source; a second polarizing beam splitter; a first detector; a second detector; an electronic circuit; and a feedback loop adapted to command the movements of the actuator in order to change and stabilize the optical path of the second arm, so that the difference signal is kept equal to a desired constant value during the gas concentration measurements.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné

Abrégé

A superconducting bipolar thermoelectric memory includes a memory cell, a connection in parallel between a bipolar thermoelectric element and a predetermined resistive load, and a writing element. A current generator is arranged to send an injected current to the thermoelectric element and the resistive load. The thermoelectric element is arranged to be heated by a predetermined thermal gradient and to generate corresponding output voltages on the resistive load depending on the sign of the injected current at the writing stage. The output voltages correspond to respective stable logic states stored by the memory resetting the bias current to zero.

Classes IPC  ?

• G11C 11/44 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des éléments supraconducteurs, p. ex. des cryotrons
• H10N 10/855 - Matériaux actifs thermoélectriques comprenant des compositions inorganiques comprenant des composés contenant du bore, du carbone, de l'oxygène ou de l'azote
• H10N 60/10 - Dispositifs à base de jonctions

Abrégé

The invention relates to short peptides, of amino acids in length, capable of binding with high affinity to the MDM2 protein and interfering with the MDM2/MDM4 heterodimer activity, thereby hindering the inhibitory function of the heterodimer against the tumor suppressor p53. The invention also relates to the use of the aforementioned peptides, or nucleic acid molecules encoding them, in the treatment of a tumor, preferably a solid tumor expressing wild-type p53.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

The present disclosure relates to a method comprising: providing a quantum register comprising a set of qubits defining a quantum system. The states of a computational basis of the quantum system may be represented by an ordered set of consecutive nonnegative integer numbers, referred to as a set of indexes. A random variable may be determined in accordance with a predefined classical-quantum format, wherein the random variable is valued in a finite domain of classical values such that each value of the domain is derived from a respective index of the set of indexes through an affine relationship, the affine relationship being defined by a scaling factor and an offset factor. The set of qubits may be encoded such that the probability of measuring a state of the quantum system in the computational basis is the probability of observing the domain value associated with the index representing said measured state when sampling the random variable.

Classes IPC  ?

• G06N 10/60 - Algorithmes quantiques, p. ex. fondés sur l'optimisation quantique ou les transformées quantiques de Fourier ou de Hadamard
• G06F 7/499 - Maniement de valeur ou d'exception, p. ex. arrondi ou dépassement

Abrégé

Polymeric scaffold (10) for myocardial regeneration and protection, comprising a support structure (20) comprising at least a first and a second support layers (30a; 30b) and at least one inner layer (33) interposed between said first and second support layers (30a; 30b), wherein said first and second support layers (30a; 30b) comprise at least one polymeric material selected from the group consisting of poly(lactic-co-glycolic acid) (PLGA), poly(dioxanone) (PDS), polycaprolactone (PCL), and polyhydroxyalkanoates (PHA), preferably poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), optionally in combination with at least one biological polymer. At least one of said support layers (30a; 30b) further comprises at least one organic and biodegradable semiconducting material, preferably an organic and biodegradable semiconducting peptide. The at least one inner layer (33) comprises a hydrogel, preferably containing an organic and biodegradable semiconducting material, more preferably an organic and biodegradable semiconducting peptide. The support layers (30a; 30b) furthermore comprise a surface sculpture, said surface sculpture comprising a plurality of cavities (41) arranged according to a regular frame, said cavities (41) being defined by an array of longitudinal linear projections (40a, 40b) and an array of transverse linear projections (40c) intersecting each other respectively, said first and second support layers (30a; 30b) having cavities (41) respectively facing opposite sides of the support structure (20).

Classes IPC  ?

• A61L 27/48 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges macromoléculaires
• A61L 27/52 - Hydrogels ou hydrocolloïdes

Abrégé

33 adenosine receptor ligand such as piclidenoson or namodenosone.

Classes IPC  ?

• A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
• A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

A method for forming a graphene layer on a semiconductor substrate, a semiconductor diode utilizing the method for graphene layer formation, and an optoelectronic semiconductor device also utilizing the method for graphene layer formation are provided. An example method for disposing a graphene layer on a semiconductor substrate may include depositing a metal catalyst layer on a top surface of the semiconductor substrate and patterning the metal catalyst layer, such that one or more portions of the top surface of the semiconductor substrate are covered by one or more metal catalyst layer structures. The method may further include facilitating a graphene growth process on an exposed surface of the one or more metal catalyst layer structures, wherein the graphene growth process forms the graphene layer on the exposed surfaces of the one or more metal catalyst layer structures.

Classes IPC  ?

• H01L 29/872 - Diodes Schottky
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
• H01L 29/66 - Types de dispositifs semi-conducteurs

Abrégé

Described is a scintigraphic intracavitary measurement device (100) comprising a supporting rod (10) extending along a main direction of extension (X) and a measuring head (20) coupled or integrated with a first end (10a) of said supporting rod (10). The measuring head (20) comprises at least one collimation element (30) configured to filter gamma radiation emitted by a source (S) defined by a suitably energised body tissue and a scintillation unit (40) configured to detect the gamma radiation emitted by the body tissue and filtered by the collimation element (30). The measuring head (20) is configured to operate with variable investigation areas (A).

Classes IPC  ?

• G01T 1/164 - Scintigraphie

Abrégé

A compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: A compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: wherein R is chosen from phenyl, a 6-membered heteroaryl group, cyclohexyl, a 5-membered heteroaryl group; a bicyclo [3.1.0] hexanyl group; a C2-C5 alkynyl group; and a cubanyl group; wherein R1 and R2, independently, are chosen from H; C1-C6 alkyl (optionally substituted with one or more halogens); C1-C6 alkyl-S(O)n—; CO2H (or C1-C6 alkyl esters thereof or C1-C6 alkyl amides thereof); halogen; C1-C6 alkoxy; CN; NO2; and NR7R8; wherein R7 and R8, independently, each represent H, C1-C6 alkyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, arylsulphonyl, heteroarylsulphonyl, heterocyclosulphonyl, arylcarbonyl, heteroarylcarbonyl, heterocyclocarbonyl, or C1-C6 alkylsulphonyl, or R7, R8 and the nitrogen to which they are attached form a 5 or 6 membered heterocyclic ring (such as morpholine or piperidine); and wherein n represents 0-2.

Classes IPC  ?

• C07D 473/06 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés en position 1 ou 3
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61K 31/522 - Purines, p. ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p. ex. hypoxanthine, guanine, acyclovir
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• A61Q 19/08 - Préparations contre le vieillissement
• C07C 273/18 - Préparation d'urée ou de ses dérivés, c.-à-d. de composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso d'urées substituées
• C07D 239/545 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués avec d'autres hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle

Abrégé

mnnmm is equal to 2 or 3, R1366Fs - COOR2and -CONR3R4, wherein R2, R3and R4are independently selected from hydrogen, linear or branched alkyls having from 1 to 4 carbon atoms or aryls preferably selected from phenyl, 2- methylbenzene, 2,4-dimethylbenzene, 2,4,6-trimethylbenzene, k is the charge of the complex and is equal to 0 or +1, and X is an anion, preferably selected from Cl-44 -66 - j j is the coefficient of the anion X and is equal to 0 or 1.

Classes IPC  ?

• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique

Abrégé

The present invention concerns a scheme that allows to create a Quantum-to-Quantum Bernoulli Factory, wherein random bits and qubits can be generated given input qubits, using a quantum photonic system that can take advantage of the different information coding approaches using states of single photons According to the invention, inversion, multiplication and sum operations can be realized with photon qubits and can be concatenated without generating noise.

Classes IPC  ?

• G06F 7/544 - Méthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs n'établissant pas de contact, p. ex. tube, dispositif à l'état solideMéthodes ou dispositions pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. en utilisant une représentation binaire, ternaire, décimale utilisant des dispositifs non spécifiés pour l'évaluation de fonctions par calcul
• G06E 3/00 - Dispositifs non prévus dans le groupe , p. ex. pour traiter des données analogiques hybrides
• G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique

Abrégé

A method for detecting a viral agent including the steps of placing a first sample that includes an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on the parameters for assessing the presence of a viral agent in at least one of the samples.

Classes IPC  ?

• G01N 22/00 - Recherche ou analyse des matériaux par l'utilisation de micro-ondes ou d'ondes radio, c.-à-d. d'ondes électromagnétiques d'une longueur d'onde d'un millimètre ou plus
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

The present invention concerns an endoscopic device (D) for sampling a sample of gastrointestinal content, comprising: an inner support (1 ), extending along an axis (X), from a first end (11 ) toward a second end (12); an outer support (2), capable of surrounding said inner support (1 ); a reservoir (3), extending along an axis X, arranged within said inner support (1 ); a plurality of permanent magnets (5), activatable by a magnetic field and configured to rotate said inner support (1 ), outer support (2) and reservoir (3) independently of each other around said axis (X); said device (D) being characterized in that said reservoir (3) includes a solution for storing said sample, and in that at least one contact and sampling element (321; 341 ) is arranged on said reservoir (3), said contact and sampling element (321; 341 ) being capable of switching from a resting position in which it is in a sterile condition, to an operating position in which it is capable of sampling the sample, and to a sample storage position in which it is in contact with said solution, within said inner support (1 ). The present invention also concerns a sampling system comprising the device (D) and an external magnet (M). The present invention also concerns a method of operation of the system.

Classes IPC  ?

• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• A61B 10/04 - Instruments endoscopiques, p. ex. instruments de type cathéther
• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie

Abrégé

A method for manufacturing a medical patch for the treatment of chronic vascular and diabetic ulcers comprises the steps of preparing a tubular support, spraying toward the axial lateral surface of said support at least two separate, simultaneous, converging jets of two nebulized solutions containing fibrinogen and thrombin, respectively, rotating the support and/or orienting the jets in such a way as to deposit on said support a layer of material (M) of predetermined size, and incubating the material (M) until the fibrin contained therein is polymerized.

Classes IPC  ?

• A61K 9/70 - Bases pour bande, feuille ou filament
• A61K 35/19 - PlaquettesMégacaryocytes
• A61K 38/36 - Facteurs de coagulation sanguine ou de fibrinolyse
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• B29C 41/08 - Revêtement d'une forme, d'un noyau ou d'un autre support par pulvérisation ou fluidisation, p. ex. pulvérisation de poudre
• B29C 41/46 - Chauffage ou refroidissement
• B29K 105/00 - Présentation, forme ou état de la matière moulée
• B29L 31/00 - Autres objets particuliers

Abrégé

A power transistor (1) for a semiconductor device, comprising: a support layer (2) made of Silicon Carbide with a bottom surface (21), at least one epitaxial layer (3) grown on its top and having a top surface (31) opposite to the bottom surface (21) along a first direction (X-X); a drain (4) arranged at least partially on the bottom surface (21); a plurality of gates and sources (5) alternately arranged on the top surface (31) and spaced apart from each other along a second direction (Y-Y); a plurality of inversion channel regions (7) generated within the thickness of the epitaxial layer (3) for transporting charges, each inclined relative to the top surface (31) by an inclination angle (α), ranging from 1° to 5°, substantially equal to the crystal basal planes (200) inclination angle (201), and each comprising a step free-area (111) and being devoid of accumulation areas (112).

Classes IPC  ?

• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
• H01L 29/66 - Types de dispositifs semi-conducteurs
• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée

Abrégé

A sensorized device (100) for detecting analytes within a fluid comprising a piezoelectric substrate (105) having an outer surface (105'), at least one R-SAW emitting interdigital transducer (111) arranged on the outer surface (105') and arranged to emit a surface acoustic wave of the Rayleigh type, also-called R-SAW, in response to an electrical input signal, said R-SAW being emitted along a first emission direction x, and at least one SH-SAW emitting interdigital transducer (112) arranged on the outer surface (105') and arranged to emit a surface acoustic wave of the shear-horizontal type, also-called SH-SAW, in response to an electrical input signal, said SH-SAW being emitted along a second emission direction y. In particular, the piezoelectric substrate (105) is made of a material selected from 64° Y-cut lithium niobate and 163° Y-cut lithium niobate, in such a way that the piezoelectric substrate (105) supports as its main mode surface acoustic waves of the shear-horizontal type, the main mode being defined as the surface acoustic wave exhibiting greater electromechanical coupling on the piezoelectric substrate (105). Furthermore, the first emission direction x and the second emission direction y have a relative angle a in such a way that 80° < α < 100°.

Classes IPC  ?

• G01N 29/02 - Analyse de fluides
• G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
• G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
• G01N 29/24 - Sondes

Abrégé

A vector for central nervous system (CNS)-specific expression, wherein the vector comprises a transgene encoding interleukin 10 (IL-10), and wherein the transgene is operably linked to one or more expression control sequence.

Classes IPC  ?

• A61K 38/20 - Interleukines
• C12N 15/67 - Méthodes générales pour favoriser l'expression
• C12N 15/861 - Vecteurs adénoviraux
• C12N 15/864 - Vecteurs parvoviraux
• C12N 15/867 - Vecteurs rétroviraux

Abrégé

The present invention relates to a computer-implemented method and corresponding apparatus for the accurate identification of subcellular structures from tomographic reconstructions. This invention allows to extract the 3D subcellular specificity directly from the tomographic phase-contrast data obtained from a typical flow cytometry configuration or any other experimental tomographic systems able to provide 3D quantitative phase-contrast tomograms. In particular, subcellular structures can be identified by using a novel computational segmentation method based on statistical inference from any 3D phase-contrast tomographic data.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
• G01N 15/10 - Recherche de particules individuelles
• G01N 15/1429 - Traitement du signal
• G01N 15/1434 - Dispositions optiques
• G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
• G06V 10/26 - Segmentation de formes dans le champ d’imageDécoupage ou fusion d’éléments d’image visant à établir la région de motif, p. ex. techniques de regroupementDétection d’occlusion
• G06V 10/34 - Lissage ou élagage de la formeOpérations morphologiquesSquelettisation
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux

Abrégé

The present patent application describes microRNAs for the diagnosis and development of advanced therapies for amyotrophic lateral sclerosis (ALS) with bulbar onset.

Classes IPC  ?

• C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

Disclosed is an apparatus and a method. Spin-splitting is induced at a superconductor and spin-polarization facilitated for tunneling across a tunnel barrier so that electric current across the tunnel barrier between a conductor and the superconductor flows primarily in one direction.

Classes IPC  ?

• H10N 50/10 - Dispositifs magnéto-résistifs
• H10N 50/85 - Matériaux de la région active
• H10N 60/10 - Dispositifs à base de jonctions

Abrégé

A Process for the preparation of a functionalized terpolymer having general formula (I): A Process for the preparation of a functionalized terpolymer having general formula (I): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): provided that in the general formula (IV) at least one of between R5, R6 and R7 differs from hydrogen and at least one of between R5, R6 and R7, contains one of the following functional groups: —COOH, —COO−M+, —SO3H, —SO3−M+, —SO2H, —SO2−M+, —OPO3H2, —OPO32−M+2, —PO3H2, —PO32−M+2, —OH, A Process for the preparation of a functionalized terpolymer having general formula (I): and including the following steps: i) reacting at least one first epoxy compound having general formula (II): with at least a second epoxy compound having general formula (III): ii) reacting the terpolymer obtained in step i) with at least one sulphur-containing compound having general formula (IV): provided that in the general formula (IV) at least one of between R5, R6 and R7 differs from hydrogen and at least one of between R5, R6 and R7, contains one of the following functional groups: —COOH, —COO−M+, —SO3H, —SO3−M+, —SO2H, —SO2−M+, —OPO3H2, —OPO32−M+2, —PO3H2, —PO32−M+2, —OH, The above process allows for terpolymers to be obtained which are soluble in polar solvents such as, for example, water, methanol, ethanol, butanol, acetone or dimethyl sulfoxide. The terpolymers can be advantageously used, for example, as additives for cements.

Classes IPC  ?

• C08G 64/34 - Procédés généraux de préparation utilisant du dioxyde de carbone et de éthers cycliques
• C04B 24/28 - Composés macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• C08G 64/02 - Polycarbonates aliphatiques
• C08G 64/42 - Post-traitement chimique

Abrégé

A method is described for extracting a gaseous or vapor component from compressed air produced by a compressor equipped with a compression chamber. The compressed air in the compression chamber is heated by the compression, is cooled at the outlet of the compression chamber, and sent to a capture device into which an absorbent fluid simultaneously enters and operates to purify it of said component. The absorbent fluid exits enriched of said component from the capture device, is heated by withdrawing heat generated by the compression process occurring in the compression chamber, and then enters a release device wherein said component desorbs into the absorbent fluid to release, at an outlet of the release device, said component extracted from the compressed air.

Classes IPC  ?

• B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption

Abrégé

A polynucleotide comprising a nucleotide sequence encoding methyl-CpG binding-protein 2 (MeCP2) and: (a) at least one miR-124 target sequence, and/or at least one miR-31 target sequence, and/or at least one miR-338-3p target sequence; and/or (b) a nucleotide sequence encoding an inhibitor of MeCP2 expression, optionally a nucleotide sequence encoding an shRNA that has at least 90% sequence identity to SEQ ID NO: 15, 30 or 31.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 38/00 - Préparations médicinales contenant des peptides

Abrégé

A process for the preparation of a doped photomobile polymer characterised by having no rubbing stage, as well as the photomobile polymer obtained by said process and a method of 3D-printing said photomobile polymer or comprising arranging a tank configured to contain a predetermined amount of a non-cross-linked resin of said photomobile polymer are described.

Classes IPC  ?

• C09K 19/52 - Substances formant des cristaux liquides caractérisées par des constituants qui ne sont pas des cristaux liquides, p. ex. additifs
• H01L 31/042 - Modules PV ou matrices de cellules PV individuelles
• H01L 31/048 - Encapsulation de modules
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• H02S 20/32 - Structures de support mobiles ou réglables, p. ex. pour réglage de l’angle spécialement adaptées pour le suivi du soleil
• C09K 19/04 - Substances formant des cristaux liquides caractérisées par la structure chimique des constituants formant des cristaux liquides
• B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
• B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux

Abrégé

A process for the preparation of a doped photomobile polymer characterised by having no rubbing stage is described, as well as the photomobile polymer obtained by said process and a handling device for moving a single solar cell to a photovoltaic panel comprising said photomobile polymer.

Classes IPC  ?

• C09K 19/52 - Substances formant des cristaux liquides caractérisées par des constituants qui ne sont pas des cristaux liquides, p. ex. additifs
• H01L 31/042 - Modules PV ou matrices de cellules PV individuelles
• H01L 31/048 - Encapsulation de modules
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• H02S 20/32 - Structures de support mobiles ou réglables, p. ex. pour réglage de l’angle spécialement adaptées pour le suivi du soleil
• C09K 19/04 - Substances formant des cristaux liquides caractérisées par la structure chimique des constituants formant des cristaux liquides

Abrégé

A method of evaluating the functionality of a preparation of extracellular vesicles (EVs) is described, which comprises incubating said preparation with fluorescein diacetate (FDA) as a non-fluorescent precursor of fluorescein under suitable conditions so that fluorescein diacetate enters the EVs of the preparation and is hydrolysed by endogenous esterase enzymes, thereby forming fluorescence-emitting fluorescein molecules. The amount of fluorescein produced, as it is related to the specific intravesicular enzymatic activity, provides a quantitative measure of the functionality of the EV preparation, i.e., the bioactivity, in particular the enzymatic activity, and integrity parameters of the vesicle membranes.

Classes IPC  ?

• C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

Devices including a plurality of antennae, methods for using the devices, and methods of diagnosing and treating a disease are disclosed.

Classes IPC  ?

• A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz
• A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 5/02 - Thérapie par radiations utilisant des hyperfréquences

Abrégé

It is disclosed a portable system for detecting an object at least partially hidden by a flame. The system comprises a first portable device comprising a fiber optic laser emitting an infrared radiation. The system also comprises a second portable device comprising a fiber optic splitter optically coupled to the fiber optic laser and an infrared detector. The fiber optic splitter divides the infrared radiation into an object beam and a reference beam, directs the object beam onto the object to be detected and directs the reference beam onto the infrared detector. The infrared detector detects a hologram formed by the reference beam interfering with the object beam scattered by the object. The system further comprises a data processing unit which reconstructs images of the object by numerically processing the hologram, and a display which visualizes the reconstructed images.

Classes IPC  ?

• G03H 1/02 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques Détails
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G02F 1/313 - Dispositifs de déflexion numérique dans une structure de guide d'ondes optique
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03H 1/26 - Procédés ou appareils adaptés spécialement pour produire des hologrammes multiples ou pour en obtenir des images, p. ex. procédés pour l'holographie à plusieurs couleurs
• G02B 6/10 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques
• G02B 6/28 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux
• G02B 27/30 - Collimateurs
• G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
• G08B 21/04 - Alarmes pour assurer la sécurité des personnes réagissant à la non-activité, p. ex. de personnes âgées

Abrégé

A heterostructure (1) based on single-element atomic layers can be integrated into a substrate of a semiconductor electronic device. The heterostructure (1) comprises a first two-dimensional layer (3) made with a first air-sensitive material, a second two-dimensional layer (4) made with a second air-sensitive material, and a protective layer (5). A conductive layer (2) covers a portion of the first two-dimensional layer (3), so that the uncovered part (O) of the first two-dimensional layer (3) is exposed to an oxidizing atmosphere and the uncovered part (O) is oxidized.

Classes IPC  ?

• H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
• H01L 21/336 - Transistors à effet de champ à grille isolée
• H01L 29/165 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée comprenant plusieurs des éléments prévus en dans différentes régions semi-conductrices
• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée

Abrégé

A device for air sanitation in circumscribed environments generates a sterilising barrier substantially consisting of superimposing a descending vertical laminar air flow and a peripherally delimited ultraviolet radiation beam also directed downwards. The device, of simplified design and small size, comprises structure for delivering a vertical laminar air flow at a controlled and humidified temperature, as well as, adjacent to such delivery structure, one or more sources for the external emission of an ultraviolet radiation beam of a wavelength appropriately chosen to offer a high germicidal action and not constitute a risk for humans. Therefore, such a substantially superimposed air flow and ultraviolet radiation beam form a barrier with high sterilising power and capable of generating confined areas. The device thus conceived is suitable for installation in circumscribed environments, typically crowded, in which the transmission of pathogens and, consequently, the risk of contagion is to be reduced. It is particularly applicable in public places such as offices, restaurants, public establishments of various kinds as well as transport.

Classes IPC  ?

• A61L 9/20 - Désinfection, stérilisation ou désodorisation de l'air utilisant des phénomènes physiques des radiations des ultraviolets

Abrégé

The present invention relates to a polymeric nanoparticle having a core@shell structure comprising poly(3-hexylthiophene) in the core and poly(3-hexylthio-phene)-S,S-dioxide in the shell with critical oxidation fraction for use in ameliorating and/or treating degenerative retinal diseases.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61P 27/02 - Agents ophtalmiques

Abrégé

An electrochemical device with a modular stack cell structure has, at one end, a cathode plate (h1) and, at the other end, a cathode plate (h2), two electrolyte membranes (ccm), and an anode plate (2a ) between the electrolytic membranes (ccm) which are arranged in a sandwich on the sides of the anode plate (2a). The cathode plates (h1, h2) include gas collection chambers (60) connected to each other via passages (61) and connection channels (16), and communicating with the outside via a hydrogen manifold (15). The anode plate (2a) has a serpentine channel (20) closed laterally by the electrolytic membranes (ccm) and communicating with the outside via an inlet manifold (21) and an outlet manifold (22).

Classes IPC  ?

• C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau

Produits et services

Filters for water purifiers; Water filters for industrial purposes; Water filters; Water purifying apparatus; Membranes for the filtration of water. Filtration of liquids; Water treatment. Water analysis; Monitoring of water quality; Technical design and planning of water purification plants.

Abrégé

The present invention relates to a di Cinnamomum zeylanicum EO, or to an association comprising said EO and one or more antitumour drug, for use in the treatment or in adjuvating the treatment of melanoma. The invention relates also to a pharmaceutical composition comprising said EO or said association and at least a pharmaceutically acceptable carrier for use in the treatment or in adjuvating the treatment of melanoma.

Classes IPC  ?

• A61K 36/54 - Lauraceae (famille du laurier), p. ex. cannelle ou sassafras
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux

Abrégé

Described is a scintigraphic measurement device with extended area, including a measurement structure having a matrix of scintillation crystals and an optoelectronic network for converting photons into electrical signals; a collimator with collimation channels; an electronic processing unit applied to the measurement structure processing the electrical signals generated by the measurement structure. The optoelectronic network has a matrix of optoelectronic conversion modules interconnected according to a two-dimensional distribution to cover the entire measurement area, each optoelectronic conversion module including a two-dimensional matrix of individual elements “Multi Pixel Photon Counter” or individual “Silicon PhotoMultiplier” elements electrically interconnected, and wherein the optoelectronic conversion modules are electrically connected to each other along rows and columns by channels for each row or column and the electronic processing unit is connected to the optoelectronic network for measuring a total electric current of each channel delivered by the optoelectronic conversion modules positioned on the channel.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal

Abrégé

A nanoparticle (1) for use in SERS spectroscopy, in particular for the detection of analytes consisting of thiolated molecules in biological fluid samples comprises a core (2) and a gold outer shell (3) between which a layer (4) of bioorthogonal Raman active molecules is interposed. The multilayer Raman active nanoparticle (1) of the invention has very low manufacturing costs and allows the indirect detection of analytes at concentrations of the picomolar order. The outer surface of the nanoparticle (1) can be engineered ad hoc to optimize the aggregation strategy as a function of the type of analyte and to detect multiple analytes in the same sample. A method for SERS spectroscopy that uses the Raman active nanoparticle (1) allows, with the same performance, to use very economical apparatuses.

Classes IPC  ?

• G01N 21/65 - Diffusion de Raman

Abrégé

The invention relates to an amorphous calcium phosphate/bioactive glass composite material (ACP/BG). This composite material possesses both the short-time ion release capability of ACP as well as the long-time ion release of BG and thus (i) efficiently remineralizes damaged enamel, and (ii) induces the formation of a new HA layer onto enamel and dentin surface. The ACP/BG composite material is obtained by embedding BG particles in a matrix of ACP nanoparticles in order to maximize homogenization between the two components and to produce a composite with high uniformity from the macro- to the nano-scale. This has been achieved with a process that includes a step of precipitating ACP onto BG particles. The BG particles can be nano-, micro-, or macro-particles. The particles can also be porous or mesoporous The invention relates also to the use of the composite material of the invention for use in the prevention of dental demineralization and to boost remineralization. In other words, the composite material here disclosed is used as remineralizing agent thanks to its ability to restore the structure and preserve the mechanical properties of dental hard tissues by releasing Ca2+and PO4 3− ions, thereby mimicking the spontaneous remineralization process induced by saliva. The composite material can also be used for bone regeneration.

Classes IPC  ?

• C01B 25/32 - Phosphates de magnésium, de calcium, de strontium ou de baryum
• A61L 27/12 - Matériaux contenant du phosphore, p. ex. apatite
• C04B 35/00 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques

Abrégé

0maxmax ranging in between that 5 of hexaferrites (up tO ~45 kJ/m3) and rare-earth-based permanent magnets (up to ~500 kJ/m3).

Classes IPC  ?

• B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p. ex. de solutions
• C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
• C22C 1/047 - Fabrication des alliages non ferreux par métallurgie des poudres comprenant des composés intermétalliques
• C22C 33/02 - Fabrication des alliages ferreux par des techniques de la métallurgie des poudres

Abrégé

A computer implemented method for real time quantum compiling includes a unitary matrix, representing a single-qubit or multi-qubit quantum operation implemented by a quantum computer, to a machine-learning trained algorithm. Information representing a base of quantum gates for building a quantum circuit corresponding to unitary matrix operation, a tolerance parameter, and processing termination information are provided to the algorithm. A quantum circuit is determined including the combination of base quantum gates. The determining is based on a policy encoded in the algorithm by reinforced learning training. Finally, information is provided on the determined quantum circuit, as a result of the real time quantum compiling. The reinforced learning training phase is based on a Reinforced Learning procedure. The Reinforced Learning procedure includes defining an unbiased set of training target unitary matrices, defining training base sets of quantum gates, and executing episodes of the Reinforced Learning procedure.

Classes IPC  ?

• G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
• G06N 3/092 - Apprentissage par renforcement

Abrégé

The technology described herein is directed to compositions and methods for isolating and analyzing biological nanoparticles, e.g., extracellular vesicles.

Classes IPC  ?

• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/566 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.

Classes IPC  ?

• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
• A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
• A61K 31/4995 - Pyrazines ou pipérazines formant une partie de systèmes cycliques pontés
• A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

Described is a scintigraphic detection device with a high degree of compactness and simplified electronics, including a scintillation structure, a collimator, an optoelectronic unit associated with the scintillation structure for converting photons into electrical signals and an electronic processing unit connected to the optoelectronic unit for processing the electrical signals generated by the optoelectronic unit, wherein the optoelectronic unit includes a plurality of individual optoelectronic conversion elements of the SiPM or MPPC type each associated with a respective collimation channel and having a surface below the transversal surface of the respective collimation channel, and wherein between each optoelectronic conversion element and the scintillation structure there is an optical guide configured for conveying and for converging the photons generated by a corresponding portion of the scintillation structure towards the optoelectronic conversion element.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal

Abrégé

Described is a measuring structure (100) for PET or SPECT applications comprising a matrix of scintillation crystals (200) each having a bar shape and extending along a longitudinal axis (X). Wherein the scintillation crystals (200) are parallel to each other and oriented in such a way as to define a measuring direction (R) that is transversal to the longitudinal axis (X). The measuring structure (100) comprises a first electronic conversion circuitry associated with the first surface (200a) of each scintillation crystal (200) for receiving an optical signal and converting it into an electric signal and a second electronic conversion circuitry associated with the second surface (200b) of each scintillation crystal (200) for receiving an optical signal and converting it into an electric signal. The scintillation crystals (200) are separated from each other by at least first sheets (300a) perpendicular to the measuring direction (R) and made of a metal material with a high atomic number designed to screen the incident radiations having energy that is lower than a predetermined threshold.

Classes IPC  ?

• G01T 1/164 - Scintigraphie
• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations

Abrégé

Sampling structure (1) for materials suspended in water, applicable to a vessel (2), comprising a suction pump (27) for suctioning water, a first filter (5) to retain microplastics and organic materials, and a container (12) to contain a predigesting solution (13) for the retained organic materials. The structure (1) also comprises a first and second pressure sensor (7, 17) arranged upstream and downstream of the main filter (5) respectively to measure water pressure values, and a command and control unit (10) to measure the water flow rate. The command and control unit is configured to calculate a control parameter as a function of the measured water pressure values and compare it with a predefined parameter to regulate the release of the predigesting solution.

Classes IPC  ?

• G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide

Abrégé

Method (1) of deposition of at least one layer of at least one precursor of Perovskite on at least one substrate (4), through use of at least one deposition chamber (2), wherein the deposition chamber (2) is operatively connected to at least one vacuum pump (3); houses at least one source (5, 5′), the at least one source (5, 5′) being configured to receive at least one precursor of said Perovskite and said at least one source (5, 5′) having at least one delivery mouth (51, 51′), to let one gas of the at least one precursor of said Perovskite, when obtained into source (5, 5′), pass directly from the at least one source (5, 5′) into the at least one deposition chamber (2); and the deposition chamber (2) houses at least one supporting device (6) for the substrate (4), the supporting device (6) being configured to support said substrate (4) between at least one working position, wherein that substrate (4) is aligned with the at least one delivery mouth (51, 51′) of the at least one source (5, 5′), at a preset deposition distance (dw) therefrom, and one resting position, wherein it is spaced apart from the at least one delivery mouth (51, 51′) of the at least one source (5, 5′), at a distance greater than said preset deposition distance (dw); and wherein the at least one substrate (4) is supported in the at least one deposition chamber (2) and the at least one precursor of said Perovskite is charged into the at least one source (5, 5′) of the deposition chamber (2); the method (1) comprising the following operational steps in sequence: A. reducing pressure into the deposition chamber (2), through activation of the vacuum pump (3), until one pressure value (P r) comprised within a preset operational pressure interval (ΔPc) is obtained; B. sublimating the at least one precursor in the at least one source (5, 5′), until one gas of the at least one precursor is obtained; C. if not yet in the working position, bringing the substrate (4) at the working position and the substrate (4) to one preset working temperature (Tw); D. depositing the at least one gas of the at least one precursor thereby sublimated, on said substrate (4); and E. cooling the at least one source (5, 5′); wherein the preset operational pressure interval is between 0.1×10−3 mbar and 100×10−3 mbar, optionally between 1×10−3 mbar and 5×10−2 mbar, more optionally between 2×10−2 mbar and 4×10−2 mbar and wherein the preset deposition distance (dw) is between 0.5 cm and 5 cm, optionally between 1 cm and 3 cm, more optionally comprised between 1.5 cm and 2.5 cm.

Classes IPC  ?

• C30B 25/16 - Commande ou régulation
• C30B 25/10 - Chauffage de l'enceinte de réaction ou du substrat
• C30B 25/14 - Moyens d'introduction et d'évacuation des gazModification du courant des gaz réactifs
• C30B 29/22 - Oxydes complexes

Abrégé

A device for transforming between an azimuthal phase and a linear phase in a charged particle beam A device for transforming between an azimuthal phase and a linear phase in a charged particle beam (10), the device comprising a first phase changing element (S1) and a second phase changing element (S2) arranged along a beam axis (20) at conjugate Fourier planes of a lens system (L1). The first phase changing element (S1) comprises a planar electrostatic arrangement of needle-shaped electrodes arranged orthogonally to the beam axis (20), the electrostatic arrangement comprising a first needle-shaped electrode (41) and a pair of second needle-shaped electrodes (42) arranged on opposite sides of, and oriented orthogonally to, the first needle-shaped electrode (41). The electrostatic arrangement further comprises a third needle-shaped electrode (43) and a pair of fourth needle-shaped electrodes (44) arranged mirror-wise with respect to the first needle-shaped electrode (41) and second needle- shaped electrodes (42), about a symmetry plane (M) arranged orthogonally to the first needle-shaped electrode (41).

Classes IPC  ?

• H01J 37/26 - Microscopes électroniques ou ioniquesTubes à diffraction d'électrons ou d'ions
• H01J 37/153 - Dispositions électronoptiques ou ionoptiques pour la correction de défauts d'images, p. ex. stigmateurs
• G21K 1/16 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des dispositifs polarisants, p. ex. pour obtenir un faisceau d'ions polarisés

Abrégé

Silicon photonic crystal (10; 10'; 10") comprising periodic silicon structures (12) contiguous with voids (14), and a silicon resonant cavity (16) consisting of silicon nanowires (18) entirely made of silicon with uniform doping, said nanowires acting as active medium of the photonic crystal.

Classes IPC  ?

• H01S 5/02 - Détails ou composants structurels non essentiels au fonctionnement laser
• B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• G02B 6/122 - Éléments optiques de base, p. ex. voies de guidage de la lumière
• H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
• H01L 33/06 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs ayant une structure à effet quantique ou un superréseau, p.ex. jonction tunnel au sein de la région électroluminescente, p.ex. structure de confinement quantique ou barrière tunnel
• H01S 5/10 - Structure ou forme du résonateur optique
• H01S 5/11 - Structure ou forme du résonateur optique comprenant une structure de bande photonique interdite
• H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]

Abrégé

It is disclosed a system and method for adjusting the alignment of a light sheet microscope. A beam splitter intercepts a fraction of light emitted by a slice of a sample illuminated by the light sheet. The intercepted light fraction is focused to form two bidimensional images on a photodetector, each bidimensional image being formed by rays coming from a respective portion of an exit pupil of the microscope's objective. At least two pairs of corresponding areas are identified in the two bidimensional images, and a mutual distance between corresponding areas of each pair is determined. A misalignment parameter indicative of a misalignment of the light sheet relative to a focal plane of the microscope's objective is then calculated, based on the determined mutual distances of the various pairs of corresponding areas. An adjustment command is then generated based on the misalignment parameter.

Classes IPC  ?

• G02B 21/24 - Structure du bâti ou statif
• G02B 21/00 - Microscopes

Abrégé

It is disclosed a system and method for multicolor light sheet microscopy, wherein at least two substantially parallel light beams having different wavelengths illuminate at least two corresponding strips of a sample. The at least two substantially parallel light beams are translated over time along a scanning direction, while keeping them at a non-null reciprocal distance YO along the scanning direction. The light emitted by the illuminated strips of the sample is split into at least two light portions following respective detection paths. Along each detection path, the corresponding light portion is subjected to a spatial filtering which isolates a light line emitted by one the illuminated strips of the sample. Such light line is finally detected by a photodetector.

Classes IPC  ?

• G02B 21/00 - Microscopes

Abrégé

The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure. The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Classes IPC  ?

• C07C 37/11 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par des réactions augmentant le nombre d'atomes de carbone
• C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
• C07D 311/80 - DibenzopyrannesDibenzopyrannes hydrogénés

Abrégé

33 -anions and Ag+cations, and said Ag+ cations then precipitate on the silicon wafer, thus resulting in the formation of multiple silver dendrites (25). The method further comprises the step of separating the silver dendrites from the silicon wafer thus obtaining a layer of isolated silver dendrites.

Classes IPC  ?

• A61F 2/30 - Articulations
• A61F 2/34 - Coques acétabulaires
• A61F 2/36 - Têtes fémorales
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques

Abrégé

The object of the invention is a method for extracting, with high yield, phycobiliproteins from cyanobacterial and/or algal biomass, obtaining extracts in water or aqueous solutions characterised by high pigment concentration and a purity degree equal to or greater than the food/cosmetic grade (P≥2). The method is based on a process characterised by a step of breaking down the cyanobacterial/algal cells by ultrasonication in an aqueous solution of ammonium sulphate, and simultaneous extraction of water-soluble compounds other than phycobiliproteins, followed by an extraction step of the phycobiliproteins using water or aqueous solutions.

Classes IPC  ?

• C07K 1/14 - ExtractionSéparationPurification
• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• C07K 14/405 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'algues

Abrégé

An epigenetic silencer factor (ESF) comprising a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 9/10 - Transférases (2.)

Abrégé

The present invention relates to a wind apparatus to maximize the amount of kinetic energy associated with an air flow captured over time by said wind apparatus. The present invention relates to a wind apparatus to maximize the amount of kinetic energy associated with an air flow captured over time by said wind apparatus. In particular, said wind apparatus comprises at least one wind system, wherein said wind system comprises at least one a bladed device provided with one or more blades and configured to be electronically controlled so that its aerodynamic behaviour changes over time based on the action exerted by said air flow on said one or more blades of said bladed device.

Classes IPC  ?

• F03D 15/00 - Transmission de l’énergie mécanique
• F03D 9/25 - Mécanismes moteurs à vent caractérisés par l’appareil entrainé l’appareil étant un générateur électrique
• H02K 7/18 - Association structurelle de génératrices électriques à des moteurs mécaniques d'entraînement, p. ex. à des turbines

Abrégé

The present invention provides compositions and methods for treating cancer in a human. The invention includes a chimeric receptor which comprises an CD64 binding domain, a transmembrane domain, and a CD3zeta signaling domain.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 14/725 - Récepteurs de lymphocytes-T
• C07K 14/735 - Récepteurs Fc
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK

Abrégé

Plant (1) and process for in situ decontamination of soil and/ or groundwater from organic and inorganic contaminants. The plant (1) comprises an extraction section (10) for extracting a predetermined flow-rate of groundwater to be decontaminated is sent to a pre- treatment section (20) where one or more primary sedimentation devices (25) are arranged. The pre- treated aqueous solution is, then, sent to a physical- chemical treatment section (30) where is subjected to a series of reactions in one or more reaction tanks (35) where the precipitation of determined contaminants is caused. A second sedimentation follows in a secondary sedimentation device (39) to physically separate the precipitated contaminants from an aqueous solution and to separate the same by filtration. The filtered aqueous solution is, then, enriched in an enrichment section (40) by adding selected chemical reagents and biological solutions and a flow-rate of oxygen modulated according to a conceptual multidimensional model designed on the basis of soil and groundwater preliminary characterization. The enriched aqueous solution is, then, injected into the subsoil at an injection section (50).

Classes IPC  ?

• B09C 1/00 - Régénération de sols pollués
• B09C 1/08 - Régénération de sols pollués par des procédés chimiques
• B09C 1/10 - Régénération de sols pollués par des procédés microbiologiques ou utilisant des enzymes
• C02F 1/40 - Dispositifs pour séparer ou enlever les substances grasses ou huileuses, ou les matières flottantes similaires
• C02F 1/00 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout
• C02F 1/72 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par oxydation
• C02F 9/00 - Traitement en plusieurs étapes de l'eau, des eaux résiduaires ou des eaux d'égout
• B01D 21/00 - Séparation par sédimentation de particules solides en suspension dans des liquides
• C02F 103/06 - Eau souterraine contaminée ou eau de lessivage

Abrégé

Described is a measuring structure (100) for PET or SPECT applications comprising a matrix of scintillation crystals (200) configured for simultaneously measuring radiation directed along respective directions, each crystal (200) extending along a longitudinal axis (X) between an upper surface (200a) and a base surface (200b) opposite the upper surface (200a), each scintillation crystal (200) having, along the longitudinal axis (X), a variable transversal section. The structure also comprises a grille (300) defining a plurality of through seats each configured for receiving a respective scintillation crystal (200). Each seat has inner walls (301) shaped to match a lateral surface of the respective scintillation crystal (200). The grille (300) is made of a metal material with a high atomic number designed to screen incident radiation.

Classes IPC  ?

• G01T 1/164 - Scintigraphie
• G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal
• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations

Produits et services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science; Chemical substances, chemical materials and chemical preparations, and natural elements; Reagents for research purposes; Reagents for scientific or medical research use; chemicals for use in scientific analysis. Ores, common metals and their alloys. Business management software; Business process management [BPM] software; Document management software; Content management software; Data and file management and database software; Research apparatus and instruments; Computer software to enable the searching of data; Dissecting instruments for scientific or research purposes; Laboratory instrument for the detection of pathogens and toxins in a biological sample for research use; Databases; Databases (electronic); Interactive databases; Simulation software; Temperature sensitive testing apparatus for scientific use; Artificial intelligence software for analysis; Testing probes, other than for medical purposes. Telecommunications services; Providing user access to search engines; Providing access to databases; Communication services between data banks; Providing telecommunications connections to the internet or databases; Transmission of database information via telecommunications networks. Material treatment information; Processing of chemicals; Heat treatment of ores; Treatment and processing of ores and ore concentrates; Metal treating; Treatment of materials using chemicals. Teaching and Training in relation to the following fields: Science; Organisation of seminars, Organisation of conventions, Organisation of courses and organization of workshops; Training in the operation of software systems; Training for handling scientific instruments and apparatus for research in laboratories; Training courses relating to database designs; Publication of material which can be accessed from databases or from the internet; Technical training relating to chemical analysis. Science and technology services; Research and design services; Industrial analysis, industrial research and industrial design services; Quality control and authentication services; Design and development of computer hardware and software; Platform as a service [PaaS]; Platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; Design of information technology infrastructure for others; Consultancy in the field of scientific research; Consultancy services relating to technological research; Providing online information about industrial analysis and research services; Provision of research services; Technical research projects and studies; Preparation of technological research reports; Research laboratories; Provision of information relating to scientific research; Research and development of new products; Research and development of computer software; Scientific research and development; Design of computer databases; Providing scientific research information and results from an online searchable database; Providing temporary use of on-line non-downloadable software for database management; Installation of database software; Research in the field of nanobiotechnology; Development of new technology for others; Research in the field of quantum simulation; Development of computer programs for simulating laboratory experiments; Environmental testing; Chemical analysis; Chemical analysis services for use in evaluation; Analysis of materials; Testing of raw materials; Analysis of product design; Industrial testing; Materials testing and analysing; Providing information about industrial analysis and research services.

Abrégé

The present invention refers to polymeric reverse micelles for delivery of hydrophilic macromolecules. In particular, it relates to a polymeric reverse micelle for the delivery of an active pharmaceutical ingredient, wherein the interior of the reverse micelle is hydrophilic and is suitable to contain a water-soluble active pharmaceutical ingredient and the exterior of the reverse micelle is hydrophobic, wherein said reverse micelle comprises at least two polymers, each one having the formula (I) disclosed in the description. A process to obtain such reverse micelle is also an object of the invention such as pharmaceutical compositions comprising the micelle.

Classes IPC  ?

• A61K 9/107 - Émulsions
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif

Abrégé

An epigenetic silencer factor (ESP), or polynucleotide encoding therefor, for use in the treatment of cancer, wherein the ESF comprises a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor, wherein the cancer is selected from the group consisting of: glioma, gliobastoma, medulloblastoma, astrocytoma, neuroblastomas, ependymoma, meningioma, retinoblastoma, rhabdomyosarcoma, lung cancer, prostate cancer, breast cancer, liver cancer, pancreatic cancer (e.g. human pancreatic ductal adenocarcinoma), bladder cancer, oropharyngeal cancer, kidney cancer, colon cancer (e.g. colon adenocarcinoma), colon-rectal cancer (CRC), or a metastasis of any of the foregoing.

Classes IPC  ?

• C07K 14/34 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Corynebacterium (G)
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C12N 15/67 - Méthodes générales pour favoriser l'expression
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 9/10 - Transférases (2.)

Abrégé

A computer-implemented method for determining a fetus ventricular volume from DWI images is provided. The computer-implemented method involves acquiring DWI images, with a pre-set voxel height, of a fetus ventricle, the acquisition being made with a single b-value selected in a range between 200 and 1000 s/mm2, selecting a ROI on each of the DWI images around the fetus ventricle, automatically clusterizing pixels in the ROI, obtaining clusterized DWI images, and calculating the fetus ventricular volume based on the number of pixels in the ROI for each of the DWI images and the pre-set voxel height. An NMR assessment system and an NMR assessment method implementing the method for determining the fetus ventricular volume are also provided.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06T 7/11 - Découpage basé sur les zones
• G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume

Abrégé

A polynucleotide comprising at least one miR-124 target sequence, and/or at least one miR- 338-3p target sequence, and/or at least one miR-31 target sequence, wherein the miRNA target sequences are operably linked to a transgene.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/86 - Vecteurs viraux

Abrégé

The present description concerns a photovoltaic module (1) and the method for installing the same. The photovoltaic module (1) comprises a light trapping optical concentrator (2). A first dichroic mirror (41) covers the bottom surface (22) of the concentrator (2), and is configured to transmit light in a first band, and to reflect light in a second band. A first photovoltaic cell (31) covers the first dichroic mirror (41) and is configured to generate electric power by conversion of light in the first band. A second photovoltaic cell (32) covers the rear surface (23) of the concentrator (2), preferably with a second dichroic mirror (42), and is configured to generate electric power by conversion of light in the second band. Characteristic of the photovoltaic module (1) is a wedge angle α selected for light in the second band to be guided by total internal reflection with a low concentrating ratio on the second photovoltaic cell (32) without the need of tilt sun tracking.

Classes IPC  ?

• H01L 31/054 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails adaptés comme dispositifs de conversion photovoltaïque [PV] Éléments optiques directement associés ou intégrés à la cellule PV, p.ex. moyens réflecteurs ou concentrateurs de lumière
• H01L 31/049 - Faces arrières protectrices
• G02B 19/00 - Condenseurs

Abrégé

Apparatus (50) for absorbing microwaves in the form of high-frequency, high-power microwave beams (100), wherein said apparatus (50) comprises a load (20) and a microwave beam (100) deflection device (10), wherein said load (20) is a bolometric device with a receiving cavity and comprises a hollow body (21) having a receiving cavity comprising an opening (25) for the entry of an incident microwave beam (100) into the receiving cavity, a scattering element (23) suitable for reflecting a multiplicity of components of said microwave beam (100) incident towards a multiplicity of angles of reflection by directing a multiplicity of components of reflected microwave beam (100) towards an internal surface (22) of the cavity, wherein said deflection device (10) comprises a body comprising a cavity, a first opening (15) of the cavity connected with said opening (25) of the cavity of the load (20) and a second opening (16) of the cavity connected with transmission lines (30) of the microwave beam (100) adapted to transport the microwave beams (100) from a source to the deflection device (10), wherein said cavity of said deflection device (10) comprises within itself at least two converging mirrors (11, 12), wherein said at least two converging mirrors (11, 12) are a first converging mirror (11) adapted to intercept the incident microwave beam (100) exiting the transmission line (30), and a second converging mirror (12) adapted to intercept the incident microwave beam (100) by deflecting it towards the opening (25) of the load (10).

Classes IPC  ?

• H01P 1/26 - Charges dispersives branchées à l'extrémité de lignes de transmission
• G01K 17/00 - Mesure d'une quantité de chaleur
• H05B 6/64 - Chauffage par micro-ondes

Abrégé

A process (100) for manufacturing a patch (10) to be applied on a human or animal organ, comprising the steps of: preparing a bio-polymeric ink (200); providing a substrate at least partially made by said bio-polymeric ink (300); printing a circuit on said substrate (400).

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/268 - Électrodes bioélectriques à cet effet caractérisées par les matériaux des électrodes contenant des polymères conducteurs, p. ex. des polymères PEDOT:PSS
• A61B 5/257 - Moyens adhésifs, p. ex. garnitures ou bandes adhésives
• C09D 11/04 - Encres d’imprimerie à base de protéines
• C09D 11/52 - Encres conductrices de l’électricité
• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains

Classes IPC  ?

• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 9/015 - Cellules cylindriques
• C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
• C25B 9/63 - Supports d'électrodesPositionnement des électrodes
• C25B 9/65 - Dispositifs pour l'alimentation en courantConnexions d'électrodesConnexions électriques intercellulaires
• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

Perovskite-based photovoltaic cell (or solar cell) wherein the perovskite photoactive layer comprises at least one partially neutralized polyacrylic acid in an amount greater than or equal to 3% by weight, preferably comprised between 4% by weight and 15% by weight, more preferably comprised between 4.5% by weight and 12% by weight, with respect to the total weight of the perovskite precursors. Said perovskite-based photovoltaic cell (or solar cell) can be advantageously used in various applications which require the production of electricity through the exploitation of light energy, in particular of solar radiation energy such as, for example: architecturally integrated photovoltaic systems (Building Integrated Photo Voltaic - BIPV); photovoltaic windows; greenhouses; photo-bioreactors; noise barriers; lighting engineering; design; advertising; automobile industry. Said perovskite-based photovoltaic cell (or solar cell) can be used both in stand-alone mode and in modular systems.

Classes IPC  ?

• H10K 85/50 - Pérovskites organiquesPérovskites hybrides organiques-inorganiques [HOIP], p. ex. CH3NH3PbI3
• H10K 30/20 - Dispositifs organiques sensibles au rayonnement infrarouge, à la lumière, au rayonnement électromagnétique de plus courte longueur d'onde ou au rayonnement corpusculaire comprenant des jonctions organiques-organiques, p. ex. des jonctions donneur-accepteur

Abrégé

This invention relates to a powder composition for inhalation use comprising a plurality of microparticles comprising at least one water-soluble pharmaceutically acceptable carrier embedding at least one nanoparticle of calcium phosphate for the delivery of therapeutic/diagnostic compounds.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The present invention concerns an extract from pomegranate (Punica granatum L), specifically obtained from one or more immature pomegranate fruits. This extract is obtained through an extraction process including steps a)-d) as described in the text and it may contain gallotannins, ellagitannins, ellagic acid derivatives and granatins. Pharmaceutical and nutraceutical compositions and food supplements comprising this extract fall within the scope of the present invention as well as their use in various fields, more specifically for the treatment of tumors.

Classes IPC  ?

• A61K 36/185 - Magnoliopsida (dicotylédones)
• A61K 31/365 - Lactones
• A61K 31/366 - Lactones ayant des cycles à six chaînons, p. ex. delta-lactones
• A61P 35/00 - Agents anticancéreux
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

Described herein is an optoelectronic device comprising : a substrate; an active layer made from at least one perovskite microwire having a longitudinal extension and having a first surface in contact with said substrate; a first electrode deposited on said substrate; a second electrode made of electrically conductive material and comprising a central tract, deposited in contact with a second surface of said at least one microwire, said second surface being opposite to said first surface.

Classes IPC  ?

• H10K 39/30 - Dispositifs commandés par rayonnement
• H10K 71/12 - Dépôt d'une matière active organique en utilisant un dépôt liquide, p. ex. revêtement par centrifugation
• H10K 85/50 - Pérovskites organiquesPérovskites hybrides organiques-inorganiques [HOIP], p. ex. CH3NH3PbI3

Abrégé

A method for controlling an electron beam with a phase modulator (20), the phase modulator comprising input contacts (22) configured to receive input signals, and an array of MEMS devices (23) for controlling an electron beam (EB), each MEMS device comprising a MEMS electrodes (24) operable to control the electron beam based on the input signals, wherein the method comprises sending to an individual input contact (22) a respective multiplexed input signal formed by a plurality of superimposed AC signals at different frequencies, demultiplexing the multiplexed input signal to a plurality of frequency channels (25) respectively associated to the MEMS electrodes (24), and rectifying and DC-converting the demultiplexed input signal in such a way that each MEMS electrode (24) is biased with a DC signal corresponding to the amplitude of one of the AC signals.

Classes IPC  ?

• H01J 37/04 - Dispositions des électrodes et organes associés en vue de produire ou de commander la décharge, p. ex. dispositif électronoptique, dispositif ionoptique
• H01J 37/26 - Microscopes électroniques ou ioniquesTubes à diffraction d'électrons ou d'ions

Abrégé

A monitoring device of biological cells including: a fluidic channel in which a fluid including biological cells is made to flow, including a first and second glass walls placed in parallel and a reflective surface adjoined to the second wall; and a piezoelectric transducer, the piezoelectric transducer emitting acoustic waves creating a force acting on the biological cells, making them flow substantially along a single motion plane. The external interface between the first wall and the exterior of the fluidic channel and the reflective surface are configured to function as a Fabry-Perot interferometer, such that the motion planes sensibly perpendicular to the optical axis of the Fabry-Perot interferometer. The finesse of the interferometer is lower than 10. The monitoring device further includes a detecting unit detecting a fringe pattern stemming from the Fabry-Perot interferometer and an analysing device, analysing the fringe pattern and configured to output data on physical properties of the cells based on the pattern.

Classes IPC  ?

• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux

Abrégé

An implantable platform for imaging in-vivo comprising: a planar substrate (10) transparent to light; at least one three-dimensional matrix (12) fabricated on a side of said planar substrate (10), configured to host biomaterial; wherein said at least one three-dimensional matrix (12) is obtained by means of two-photon photo-polymerisation and is luminescent under infrared excitation by two-photon absorption; at least one micro-optical device (11), comprising at least one lens (20, 21, 22), fabricated by means of two-photon photo-polymerisation or nanoimprinting lithography on the other side of said planar substrate (10) placed in correspondence of said a least one three-dimensional matrix (12); wherein said implantable platform for imaging in-vivo is configured to be implantable below the skin of a laboratory animal.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

A device (1) for the bilateral rehabilitation of a user's limbs, comprising a main body (5) connected to a connecting base (2), a first motor (7') and a second motor (7'') supported by the main body (5), a first rotary interface (8') and a second rotary interface (8'') supported by the main body (5) rotatably operable about first and second rotation axes (15', 15'') by the motors (7', 7''), grip accessories (12.1, 12.2,..., 12.n) having a grip portion (13) and a coupling portion (14) couplable to the first (8') and second (8'') rotary interfaces, an electronic control device (11) configured to control the rotary movements and the torques applied to the first (8') and second (8'') rotary interfaces depending on angular positions or torques detected by position detecting means (9', 9'') or torque detecting means (10', 10''), wherein the main body (5) is connected to the connecting base (2) by means of an adjustable and lockable joint (6) which allows an adjustment and locking of the position of the main body (5) with respect to the connecting base (2) in at least three different body positions with different orientations of the first (15') and second (15'') rotation axes.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• A63B 21/00 - Appareils de gymnastique pour développer ou fortifier les muscles ou les articulations du corps en surmontant des résistances, avec ou sans dispositifs de mesure
• A63B 22/00 - Appareils d'exercice spécialement adaptés à l'entraînement du système cardio-vasculaire, pour exercer l'agilité ou la coordination des mouvements
• A63B 23/035 - Appareils d'exercice spécialement adaptés à des parties déterminées du corps pour les membres, c.-à-d. supérieurs ou inférieurs, p. ex. en même temps
• A63B 71/00 - Accessoires pour jeux ou sports non couverts dans les groupes
• A63B 21/16 - Supports d'ancrage des dispositifs résistants à friction
• A63B 23/12 - Appareils d'exercice spécialement adaptés à des parties déterminées du corps pour les membres, c.-à-d. supérieurs ou inférieurs, p. ex. en même temps pour les membres supérieurs

Abrégé

The invention concerns nanovesicles of nanostructured myelin and uses thereof in the treatment of demyelinating and neurodegenerative diseases of the central (CNS) and peripheral (PNS) nervous system. Under another aspect, processes for the preparation of myelin nanovesicles having particular characteristics that make them suitable for recovery of the myelin sheath, where it is compromised, as a drug delivery system for CNS or PNS, and for immunotolerance, are described.

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique

Abrégé

An adeno-associated viral (AAV) capsid protein, wherein the capsid protein comprises: (a) a peptide comprising or consisting of the amino acid sequence PGVPGRF, or a variant thereof having up to two amino acid substitutions, additions or deletions; or (b) a peptide comprising or consisting of the amino acid sequence NGVRSVG, or a variant thereof having up to two amino acid substitutions, additions or deletions.

Classes IPC  ?

• C07K 14/075 - Adénoviridae

Abrégé

An adeno-associated viral (AAV) capsid protein, wherein the capsid protein comprises: (a) a peptide comprising or consisting of the amino acid sequence PGVPGRF, or a variant thereof having up to two amino acid substitutions, additions or deletions; or (b) a peptide comprising or consisting of the amino acid sequence NGVRSVG, or a variant thereof having up to two amino acid substitutions, additions or deletions.

Classes IPC  ?

• C07K 14/075 - Adénoviridae

Abrégé

The invention relates to a composition of lipid vesicles, preferably extracellular vesicles (EVs), displaying the protein Cripto on their surface, for use in the therapeutic treatment of a primary tumour or in the therapeutic or preventive treatment of tumour metastases, such as for example glioblastoma or glioblastoma metastases.

Classes IPC  ?

• A61K 38/18 - Facteurs de croissanceRégulateurs de croissance
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/485 - Facteur de croissance de l'épiderme [EGF], c.-à-d. urogastrone

Abrégé

Superconducting interferometer (20) comprising two SQUIPTs (100, 200), each comprising a superconducting loops (24a, 24b), placed in parallel between a first terminal (22) arranged to be connected to a ground voltage and two metal tunnel probes (26a, 26b), the interferometer (20) being arranged to be placed into a magnetic flux (Φ) and a first current (I1) and a second current (I2) flowing through a first Josephson junction (28a) and a second Josephson junction (28b) placed into a respective loops (24a, 24b), thus producing a respective voltage drop (V1, V2) at each tunnel probe (26a, 26b), wherein the interferometer (20) is arranged to generate an output voltage (Vout) as a function of said voltage drops (V1, V2), said output voltage (Vout) being a linear function of the magnetic flux (Φ) given a predetermined additional component (Δφ) of the magnetic flux (Φ) introduced into one of the two loops (24a, 24b).

Classes IPC  ?

• G01R 33/035 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs supraconducteurs

Abrégé

A multifunction gamma radiation detector includes a supporting rod, a detection head coupled to or integrated with a first end of the supporting rod including detection elements separate from each other for simultaneously detecting gamma radiation directed along respective directions. Each detection element includes a scintillation crystal and corresponding first electronic conversion circuitry for receiving an optical signal from the crystal and converting it into an electrical signal. The detector also includes a handgrip, connectable to a second end of the supporting rod and which can be manually gripped by an operator to direct the detector, and a second electronic circuitry for converting and/or treating the signals connected to the first electronic conversion circuitry. The head also includes an optical detection device acquiring a sequence of optical signals emitted by a suitably energized body tissue. The detection elements are angularly distributed on the detection head about optical detection device.

Classes IPC  ?

• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• G01T 1/164 - Scintigraphie

Abrégé

It is disclosed a device for multipole phase division multiplexing and demultiplexing and a spatial division telecommunications system comprising the multiplexing and demultiplexing devices. The multipole phase demultiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a circular-sector transformation of a plurality of multipole phase electromagnetic beams. The multipole phase multiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a combination of |m | circular-sector transformations of a plurality of tilted electromagnetic beams.

Classes IPC  ?

• H04B 10/2581 - Transmission multimode
• H04J 14/04 - Systèmes multiplex par mode

Abrégé

A microfluidic patch for separating specific species in biological fluids, comprising a flow layer comprising: a first porous portion to receive and carry a starting biological fluid containing related species; a multilayer membrane downstream the first porous portion and comprising a plurality of graphene-based sheets spaced among each other to define a plurality of parallel channels transversally interconnected and chemically functionalized to provide from the starting biological fluid an outgoing flow of specific species to be detected; and a second porous portion placed downstream the multilayer membrane to receive and carry the outgoing flow to be detected; the patch comprises a first upstream electrode and a first downstream electrode placed respectively upstream and downstream the multilayer membrane to foster the flow through the multilayer membrane from the first to the second porous portion.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/1477 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques non invasifs

Abrégé

Provided is an atomic vapor cell, for atomic or molecular spectroscopy, optical pumping, and/or spin-based atomic sensing, that includes a host substrate and defined there within a buried or non-buried chamber laser written in the host substrate without the need of a mask or photoresist, with either planar or three-dimensional geometry, and intended to contain an atomic vapor. Also provided are an integrated atomic/photonic device and an apparatus, in both cases including the presently disclosed atomic vapor cell, and a method for fabricating the presently disclosed atomic vapor cell.

Classes IPC  ?

• G01R 33/26 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique pour la mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques utilisant le pompage optique
• G01R 33/46 - Spectroscopie RMN

Abrégé

A patterned light generating device (100, 300) for microscopy comprising: at least a first optical waveguide (1) and a second optical waveguide (2), the waveguides (1, 2) being configured for transmitting a polarized light beam to their ends; at least one coupler (12) for splitting a laser beam entering the device (100, 300) between the first waveguide (1) and the second waveguide (2); a substrate (7), preferably of glass, having one input port and at least a first output port and a second output port, said substrate (7) being configured for housing the waveguides (1, 2) and the at least one coupler (12); an input polarization maintaining fibre (10) fixed at the input port and configured for coupling the laser beam into the first waveguide (1); and at least a first output polarization maintaining fibre (21) fixed at the first output port and configured for being coupled with the first waveguide (1) in such a way to transmit a light beam from the first waveguide to an end of the first output polarization maintaining fibre (21) and a second output polarization maintaining fibre (22) fixed at the second output port and configured for being coupled with the second waveguide (2) in such a way to transmit a light beam from the second waveguide to an end of the second output polarization maintaining fibre (22); at least one phase shifter (11) configured for creating a phase difference between the first waveguide (1) and the second waveguide (2), the phase shifter (11) being housed in the substrate (7); and a glass ferrule (30) configured to being coupled with the output polarization fibres (21, 22), the output polarization fibres (21, 22) ending into the ferrule (30) in such a way to be oriented one respect to the other by an angle equal to the round angle divided by the number of waveguides (1, 2).

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

A geopolymeric material is described having compressive strength at 28 days ranging from 15 to 100 N/mm2, obtainable by curing for 12 hours at a temperature ranging from 20° C. to 60° C., from a geopolymeric aqueous mixture comprising the following inorganic components in the following parts by dry mass: metakaolin 1565 potassium silicate and/or sodium silicate 2040 aggregates recycled from CDW (Construction and Demolition Waste) 5300; said geopolymeric aqueous mixture is obtainable by mixing 20175 parts by mass of water with said inorganic components, and has a viscosity at 23° C. between 100 and 10000 Pa·s, wherein: i) the viscosity is measured via Brookfield methodology, ii) the aggregates recycled from CDW belong to one or more of the classes 17.01.01, 17.01.02, 17.01.03, 17.01.07 according to the European Waste Catalogue, iii) the aggregates recycled from CDW have a grain size less than or equal to 4 mm, preferably less than or equal to 2 mm.

Classes IPC  ?

• C04B 28/00 - Compositions pour mortiers, béton ou pierre artificielle, contenant des liants inorganiques ou contenant le produit de réaction d'un liant inorganique et d'un liant organique, p. ex. contenant des ciments de polycarboxylates
• C04B 14/10 - Argile
• C04B 18/167 - Matières recyclées, c.-à-d. déchets réutilisés dans la production des mêmes matières
• C04B 18/06 - Résidus de combustion, p. ex. produits d'épuration des fumées, des émanations ou des gaz d'échappement
• C04B 18/08 - Cendres volantes
• E04F 13/08 - Revêtements ou enduits, p. ex. pour murs ou plafonds constitués d'éléments d'habillage ou de garnissageLeurs bâtisLeurs moyens de fixation constitués de plusieurs éléments d'habillage ou de garnissage semblables
• E04F 13/14 - Revêtements ou enduits, p. ex. pour murs ou plafonds constitués d'éléments d'habillage ou de garnissageLeurs bâtisLeurs moyens de fixation constitués de plusieurs éléments d'habillage ou de garnissage semblables en pierre ou en matériau similaire, p. ex. en céramique en verre
• F24D 3/12 - Aménagements de tubes et panneaux pour le chauffage par plafond, mur ou sol

Abrégé

A process for the synthesis of nanocrystals of metal chalcohalides is disclosed, where M is a metal, E is a chalcogen and X is a halogen, starting from a salt of M. The process includes the following steps: a) a precursor of metal M is mixed with a surfactant in a solvent having a boiling point higher than 180 °C; b) the mixture obtained in previous step a) is heated, in order to dissolve the components, until it becomes clear; c) the solution is heated up under inert atmosphere at the desired temperature; d) chalcogen and halogen precursors in 0 a solvent having a boiling point higher than 180 °C are added through injection, while heating the solution obtained in steps a) to c); e) after the reaction time has elapsed, the product is quenched down to room temperature.

Classes IPC  ?

• C01G 29/00 - Composés du bismuth
• C01B 19/00 - SéléniumTellureLeurs composés
• C01G 30/00 - Composés de l'antimoine
• C09D 11/00 - Encres

Produits et services

Academies [education]; Teaching; Teaching; Production of shows; Arranging and conducting of conferences; Arranging and conducting of congresses; Organization of exhibitions for cultural or educational purposes; Vocational guidance [education or training advice]; Conducting guided tours; Arranging of exhibitions for training purposes; Arranging of displays for training purposes; Organizing and arranging exhibitions for entertainment purposes; Organisation of conferences, exhibitions and competitions.

Produits et services

Academies [education]; Teaching; Teaching; Production of shows; Arranging and conducting of conferences; Arranging and conducting of congresses; Organization of exhibitions for cultural or educational purposes; Vocational guidance [education or training advice]; Conducting guided tours; Arranging of exhibitions for training purposes; Arranging of displays for training purposes; Organizing and arranging exhibitions for entertainment purposes; Organisation of conferences, exhibitions and competitions.

Produits et services

Teaching; Training; Entertainment services; Sporting and cultural activities; Teaching, Organisation of seminars, Publication of.

Abrégé

The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

Classes IPC  ?

• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The invention concerns a compound of formula (I) or pharmaceutically acceptable salts or hydrates thereof: (I) wherein R represents a 6-membered aryl or heteroaryl group or a 5-membered heteroaryl group, optionally substituted with at least one halogen atom, for use as a medicament. The invention also concerns a pharmaceutical composition comprising, as active ingredient, at least one compound of formula (I), as above, or pharmaceutically acceptable salts or hydrates thereof, and at least one pharmaceutically acceptable excipient, and the pharmaceutical composition for use as a medicament. The invention also concerns such compound or pharmaceutical composition for use as HSP90 inhibitor, in selectively killing senescent cells, in delaying ageing in a subject and in the treatment and/ or prevention of a senescence -associated disease or disorder. The invention also concerns a method for preparing such compound. The invention also concerns the cosmetic use of the compounds of formula (I) or cosmetically acceptable salts or hydrates thereof, and of a cosmetic composition that comprises at least one such compound.

Classes IPC  ?

• C07C 307/00 - Amides d'acides sulfuriques, c.-à-d. composés comportant des atomes d'oxygène, liés par des liaisons simples, de groupes sulfate remplacés par des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso
• A61K 31/15 - Oximes (C=N-O-)Hydrazines ( N-N)Hydrazones (N-N=)
• A61K 8/00 - Cosmétiques ou préparations similaires pour la toilette
• A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 27/02 - Agents ophtalmiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 31/12 - Antiviraux
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07C 305/00 - Esters d'acides sulfuriques
• C07D 203/24 - Atomes de soufre

Abrégé

2516n21616162781-6161-616788 and the nitrogen to which they are attached form a 5 or • 6 membered heterocyclic ring (such as morpholine or piperidine); and • - n represents 0-2; for use as a medicament, in particular as HSP90 inhibitor, in selectively killing senescent cells, in delaying ageing in a subject and in the treatment and/or prevention of a senescence-associated disease or disorder.

Classes IPC  ?

• A61K 31/522 - Purines, p. ex. adénine ayant des groupes oxo liés directement à l'hétérocycle, p. ex. hypoxanthine, guanine, acyclovir
• A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• A61P 27/02 - Agents ophtalmiques
• A61P 35/00 - Agents anticancéreux
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07D 473/04 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène
• C07D 473/06 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés en position 1 ou 3
• A61Q 19/08 - Préparations contre le vieillissement
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques

Abrégé

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

Classes IPC  ?

• A61K 38/53 - Ligases (6)
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

Abrégé

iniiiiiii of the input vector x into probability amplitudes of a n-qubits initial first quantum state, stored in an input register q, through a n-to-2ninput encoding model, wherein the number of qubits n of the initial first quantum state is such that 2nininin corresponds to the input vector dimension; - applying a quantum operator, depending on the weight values wi of the weight vector w and the bias b, to said input register q to calculate said argument z as the addition of the bias b and the inner product of the input vector x and the weight vector w; - by the application of said quantum operator, producing as result a second quantum state, of the input register q, which has the value 1 and the value of the argument (z) encoded; - processing, by a second quantum process, said second quantum state of the input register (q), to calculate a value of each of a number of powers (d-1) of said argument (z), from the second order power (z2) up to the d-th order power (zd), using an additional quantum buffer register (a); - by the application of said second quantum process, producing as result a third (n+d)-qubits quantum state, of the input register (q) and the additional quantum buffer register (a), which has said values (1, z, z2,..., zd) encoded; - processing, by a third quantum process, said third quantum state to calculate said computation result y as a polynomial series expansion of the activation function f, through quantum states rotations, with the rotation angles depending on coefficients of said activation function polynomial series expansion; - encoding said calculated computation result y into a fourth quantum state, which is suitable either to be measured and detected or to be provided, as a not yet measured quantum state, to a further neuron of the neural network. A computer implemented method for implementing a quantum neural network is also described. A quantum computation system for performing quantum calculations in a quantum neural network and a quantum computation system for implementing a quantum neural network are also described.

Classes IPC  ?

• G06N 3/048 - Fonctions d’activation
• G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels

Abrégé

The present invention relates to peptidomimetics of a short peptide from leucyl-tRNA synthetase, compositions comprising one or more of said peptidomimetics and their use for the treatment of syndromes caused by mutations of mt-tRNA (mitochondrial transfer RNA) genes, and medical treatments of said syndromes comprising the administration of said one or more peptidomimetics or compositions comprising the same.

Classes IPC  ?

• A61K 38/53 - Ligases (6)
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides

Abrégé

A photoacoustic sensor for spectroscopic gas detection, comprising a chamber adapted to contain the gas to be analysed, an excitation laser source adapted to emit a modulated laser beam, which is absorbed by the gas present in the chamber and creating a pressure wave, a transducer, the transducer being located inside the chamber, and being adapted to be put into oscillations by the pressure wave, the transducer having a reflective portion, an interferometer having a first and a second arm and an output able to detect the oscillations of the transducer, with the first arm ending in the transducer, and the second arm including an optical path changer element and an actuator connected to the optical path changer element to change the optical path defined by the second arm of the interferometer, a first polarizing beam splitter, a second laser source for interferometer reading, adapted to emit a second laser beam impinging onto the first polarizing beam splitter, the first polarizing beam splitter being adapted to split the second laser beam in the first and the second arm of the interferometer, so that the split beam travelling in the first arm is back- reflected by the reflective portion of the transducer, and the split beam travelling in the second arm is back-reflected by the optical path changer element, so that the resulting back-reflected split beams interfere in the interferometer, a second polarizing beam splitter adapted to split the interfering light at the output of the interferometer in two beams which are orthogonally polarized, a first detector adapted to detect one of the two orthogonally polarized beam exiting the interferometer and to generate a corresponding first electric signal, a second detector adapted to detect the other of the two orthogonally polarized beam exiting the interferometer and to generate a corresponding second electric signal, an electronic circuit configured to obtain a difference signal, the difference signal being function of the difference between the signal generated by the first detector and the signal generated by the second detector, and a feedback loop adapted to command the movements of the actuator in order to change and stabilize the optical path of the second arm, so that the difference signal is kept equal to a desired constant value during the gas concentration measurements.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
• G01N 29/24 - Sondes

Abrégé

bLLbLLL-)corresponding to respective stable logic states (0, 1) stored by the memory (1) resetting the bias current to zero.

Classes IPC  ?

• G11C 11/44 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des éléments supraconducteurs, p. ex. des cryotrons
• H10N 10/00 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier
• H10N 60/00 - Dispositifs supraconducteurs

Abrégé

Provided are methods of transducing hair cells of the inner ear in a subject comprising administering to the subject an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a capsid comprising the amino acid sequence of SEQ ID NO: 1, wherein the AAV vector further comprises a heterologous nucleic acid sequence. Additionally, methods of treating, preventing, or inhibiting a cochlear disorder or balance disorder in a subject comprising administering the AAV vector to the subject are provided.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 27/16 - Otologiques
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur