Goods & Services

Pharmaceuticals, medical and veterinary preparations; pharmaceutical preparations and vaccines for use in gene therapy and cell therapy; biological preparations for use in medical and clinical gene therapy and cell therapy; clinical medical reagents for use in gene therapy, gene diagnosis and gene testing. Recorded and downloadable media, computer software, blank digital or analogue recording and storage media for use in the medical and pharmaceutical field; downloadable mobile applications for the management and transmission of information in the medical and pharmaceutical field; downloadable publications in the medical and pharmaceutical field; electronic publications in the medical and pharmaceutical field. Medical apparatus and instruments; Surgical apparatus and instruments for medical use; implantable medical devices; apparatus for use in medical analysis. Medical education services; conducting of educational seminars and training relating to medical and pharmaceutical matters; publication of journals, newspapers, photographs, catalogues, leaflets, brochures, magazines, manuals, booklets, posters, and texts relating to the medical and pharmaceutical field; providing non-downloadable videos relating to the medical and pharmaceutical field. Providing scientific information in the field of medical disorders and their treatment; provision of information and data relating to medical and pharmaceutical research and development; Providing medical and scientific research information relating to diseases, pharmaceuticals, and clinical trials; hosting websites on the Internet; software as a service [SaaS] featuring software for analyzing and reporting self-assessment of illness; software as a service [SaaS] featuring software platforms for use in providing medical and scientific research information to pharmaceutical companies, health care providers, healthcare professionals, and patients. Medical information services; health care information services; patient support services.

Abstract

The present disclosure relates generally to envelope-binding proteins and their use in methods of producing and/or purifying an enveloped virus from cell culture.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Goods & Services

Promoting the donation of blood plasma by means of arranging and conducting incentive reward and blood plasma donor loyalty programs, administration of an incentive reward and blood plasma donor loyalty program to promote blood plasma collection services and collection of blood plasma

Goods & Services

(1) Providing medical and scientific research information in the field of general health and wellness and pharmaceuticals; Scientific research in the field of pharmacology, pharmaceuticals, and biochemistry; product research and development services, namely, scientific, medical, pharmaceutical and blood products research and development services in the field of new pharmaceuticals; pharmaceutical research and development; research and development in the field of vaccines and medicines; Providing medical and scientific research information in the field of pharmaceuticals, clinical trials, blood conditions, blood illnesses and blood diseases, namely via a global computer network; Providing medical and scientific research information in the field of clinical trials and pharmaceuticals. (2) Providing medical information and treatment information in the field of general health and wellness; medical services; medical services, namely, providing medical information concerning blood products, providing medical information concerning health products and services; health care, namely, providing information in the field of general health and wellness in person, via the internet, and through the distribution of printed matter.

Goods & Services

Providing medical and scientific research information in the field of health and pharmaceuticals; Scientific research; product research and development services, including scientific, medical, pharmaceutical and blood products research and development services; pharmaceutical research and development; research and development of vaccines and medicines; Providing medical and scientific research information in the field of pharmaceuticals, clinical trials, blood conditions, blood illnesses and blood diseases, including via a global computer network; Providing medical and scientific research information in the field of clinical trials and pharmaceuticals. Providing medical information and treatment information in the field of health; medical services; medical services, namely, providing medical information concerning blood products, providing medical information concerning health products and services; health care, namely, providing health care information in person, via the internet, and through the distribution of printed matter.

Goods & Services

Pharmaceuticals, medical and veterinary preparations; pharmaceutical preparations and vaccines for use in gene therapy and cell therapy; biological preparations for use in medical and clinical gene therapy and cell therapy; clinical medical reagents for use in gene therapy, gene diagnosis and gene testing. Recorded and downloadable media, computer software, blank digital or analogue recording and storage media for use in the medical and pharmaceutical field; downloadable mobile applications for the management and transmission of information in the medical and pharmaceutical field; downloadable publications in the medical and pharmaceutical field; electronic publications in the medical and pharmaceutical field. Medical apparatus and instruments; Surgical apparatus and instruments for medical use; implantable medical devices; apparatus for use in medical analysis. Medical education services; conducting of educational seminars and training relating to medical and pharmaceutical matters; publication of journals, newspapers, photographs, catalogues, leaflets, brochures, magazines, manuals, booklets, posters, and texts relating to the medical and pharmaceutical field; providing non-downloadable videos relating to the medical and pharmaceutical field. Providing scientific information in the field of medical disorders and their treatment; provision of information and data relating to medical and pharmaceutical research and development; Providing medical and scientific research information relating to diseases, pharmaceuticals, and clinical trials; hosting websites on the Internet; software as a service [SaaS] featuring software for analyzing and reporting self-assessment of illness; software as a service [SaaS] featuring software platforms for use in providing medical and scientific research information to pharmaceutical companies, health care providers, healthcare professionals, and patients. Medical information services; health care information services; patient support services.

Abstract

The present disclosure relates generally to the manufacturing of gene therapy products and specifically to viral vector formulations comprising a high-density additive for increasing transduction of a cell with a viral vector and/or methods of transducing a cell with a viral vector in a cell culture and/or methods of increasing a viral vector transduction efficiency of a cell in a cell culture, the methods comprising using a viral vector formulation comprising a high-density additive, wherein the formulation has a density greater than the density of the cell culture medium.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61K 39/12 - Viral antigens
• A61K 35/66 - Microorganisms or materials therefrom

Goods & Services

Pharmaceutical preparations for treating von Willebrand disease, hemophilia, primary immunodeficiency, hereditary angioedema, fibrinogen deficiency, Alpha 1antitrypsin deficiency, and inflammatory demyelinating polyneuropathy; blood plasma; blood plasma fractions; recombinant protein arrays for medical diagnosis purposes; Pharmaceutical preparations for the treatment and prevention of blood and bleeding disorders; blood products for the treatment of hemophilia, namely, pharmaceutical preparations for the treatment of hemophilia; pharmaceutical products derived from recombinant DNA technology for the treatment of hemophilia, namely, pharmaceutical preparations derived from recombinant DNA technology for the treatment of hemophilia; blood products for the treatment of hemophilia, namely, a blood clotting aid and delivery system for use in human and veterinary medicine; pharmaceutical preparations and substances for the treatment of blood disorders; antibodies, namely, diagnostic kits consisting primarily of monoclonal antibodies, buffers, and reagents for use in disease testing; blood for medical purposes; cell cultures for medical purposes, namely, cells for medical or clinical use; cell cultures for medical purposes, namely, living cells for medical use; cell cultures for medical purposes, namely, stem cells for medical or veterinary use; pharmaceutical preparations for the treatment of blood conditions, respiratory conditions, pneumonia, covid-19, and influenza; Pharmaceutical preparations, namely, antibody for the treatment of acute respiratory distress syndrome, ARDS; pharmaceutical preparations, namely, antibody for the treatment of Idiopathic Pulmonary Fibrosis, IPF and Interstitial Lung Diseases, ILD; Pharmaceutical preparations, namely, antibody for the treatment of Hereditary Angioedema, HAE

Goods & Services

Pharmaceutical preparations for treating von Willebrand disease, hemophilia, primary immunodeficiency, hereditary angioedema, fibrinogen deficiency, Alpha 1 antitrypsin deficiency, and inflammatory demyelinating polyneuropathy; blood plasma; blood plasma fractions; recombinant protein arrays for medical diagnosis purposes; Pharmaceutical preparations for the treatment and prevention of blood and bleeding disorders; blood products for the treatment of hemophilia, namely, pharmaceutical preparations for the treatment of hemophilia; pharmaceutical products derived from recombinant DNA technology for the treatment of hemophilia, namely, pharmaceutical preparations derived from recombinant DNA technology for the treatment of hemophilia; blood products for the treatment of hemophilia, namely, a blood clotting aid and delivery system for use in human and veterinary medicine; pharmaceutical preparations and substances for the treatment of blood disorders; antibodies, namely, diagnostic kits consisting primarily of monoclonal antibodies, buffers, and reagents for use in disease testing; blood for medical purposes; cell cultures for medical purposes, namely, cells for medical or clinical use; cell cultures for medical purposes, namely, living cells for medical use; cell cultures for medical purposes, namely, stem cells for medical or veterinary use; pharmaceutical preparations for the treatment of blood conditions, respiratory conditions, pneumonia, covid-19, and influenza; Pharmaceutical preparations, namely, antibody for the treatment of acute respiratory distress syndrome, ARDS; pharmaceutical preparations, namely, antibody for the treatment of Idiopathic Pulmonary Fibrosis, IPF and Interstitial Lung Diseases, ILD; Pharmaceutical preparations, namely, antibody for the treatment of Hereditary Angioedema, HAE

Abstract

The present disclosure relates generally to the manufacturing of gene therapy products, and specifically to methods of purifying an enveloped virus from a cell culture fluid, comprising a filtration medium.

IPC Classes  ?

• C12N 7/02 - Recovery or purification
• B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
• B01D 37/00 - Processes of filtration
• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
• B01D 63/14 - Pleat-type membrane modules
• B01D 69/12 - Composite membranesUltra-thin membranes

Goods & Services

Educational services, namely, conducting classes, seminars, conferences, and workshops in the field of healthcare; Publication of the results of clinical trials; Education services, namely, conducting classes, seminars, conferences, and workshops, in the field of therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Provision of medical information.

Goods & Services

Educational services, namely, conducting classes, seminars, conferences, and workshops in the field of healthcare; Publication of the results of clinical trials; Education services, namely, conducting classes, seminars, conferences, and workshops, in the field of therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Provision of medical information.

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Educational services, namely, conducting classes, seminars, conferences, and workshops in the field of healthcare; Publication of the results of clinical trials; Education services, namely, conducting classes, seminars, conferences, and workshops, in the field of therapeutic treatments Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Provision of medical information

Goods & Services

Educational services, namely, conducting classes, seminars, conferences, and workshops in the field of healthcare; Publication of the results of clinical trials; Education services, namely, conducting classes, seminars, conferences, and workshops, in the field of therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals; Provision of medical information.

Abstract

The present disclosure relates generally to the manufacturing of gene therapy products, and specifically to methods of transducing a cell with an enveloped virus in a cell culture, methods of increasing an enveloped virus transduction efficiency of a cell in a cell culture and/or methods of increasing potency of an enveloped virus during transduction of a cell in a cell culture, the method contacting a plurality of cells in a cell culture medium with the enveloped virus and a transduction enhancer of Formula (I) or a stereoisomer, a racemate, a pharmaceutically acceptable salt or a solvate thereof.

IPC Classes  ?

• C12N 5/074 - Adult stem cells
• C07D 407/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C12N 15/86 - Viral vectors

Goods & Services

Human albumin [pharmaceutical preparations] for use in human therapy.

Abstract

The present disclosure relates to Wiskott-Aldrich Syndrome (WAS) binding proteins and uses thereof. The present disclosure further relates to WAS protein variants thereof and methods of producing WAS binding proteins thereof.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/33 - AntibodiesT-cell engagers

Abstract

The present disclosure relates to methods of producing an enveloped virus in a suspension cell culture, the method comprising culturing a suspension cell line expressing a tetracycline-suppressible gene expression system in a cell culture medium. The present disclosure also relates to stable producer cell clones capable of producing an enveloped virus in a suspension cell culture.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
• C12N 15/86 - Viral vectors

Abstract

This disclosure relates generally to lentiviral vectors useful for the treatment of a disease or condition, for example, Wiskott-Aldrich Syndrome (WAS) or Sickle Cell Disease (SCD).

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Goods & Services

Human albumin [pharmaceutical preparations] for use in human therapy.

Goods & Services

conducting educational programs in the field of healthcare for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; arranging and conducting educational seminars in the field of healthcare related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Educational services, namely, providing educational speakers in the field of healthcare; Peer to peer healthcare provider coaching services in the field of healthcare; Medical training and teaching in the field of healthcare; Training services in the field of healthcare; Providing on-line training in the field of healthcare; Providing on-line training in the field of healthcare on a peer to peer basis; Training in the use of healthcare products and pharmaceuticals Providing educational information about healthcare for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; providing educational information about healthcare related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professional

Goods & Services

Information on financial administration of patient reimbursement programs; Insurance information and consultancy; charitable services, namely, providing financial support and financial information to patients and caregivers for obtaining medications and medical treatment; Providing insurance information for patients diagnosed with medical conditions regarding medication access and reimbursement programs and insurance premium and co-pay assistance; providing insurance consulting services to patients diagnosed with medical conditions regarding obtaining approval, authorization, and verification of insurance coverage for treatment, determining existing insurance benefits, and appealing from denial of insurance coverage and acquiring letters of medical necessity for insurance coverage; providing financial co-pay assistance to patients for health care. Training services in the field of medical injection training and pharmaceutical administration training health care, namely, providing health care information by telephone, the internet, and through the distribution of printed matter; charitable services, namely, providing medical information to patients and caregivers for obtaining medications and medical treatment; Providing medical information for patients diagnosed with medical conditions regarding available resources and treatments and steps and actions for wellness, and healthy living; providing medical counseling for patients with medical conditions; medical services, namely, providing medical information through charitable actions in the nature of information for the continuance of medication for those who are underinsured, uninsured, or who have experienced a lapse in insurance coverage; Medical services, namely, providing medical information concerning blood products and concerning pharmaceutical products, including providing information on preparing and self-administering medications. Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support.

Goods & Services

Information on financial administration of patient reimbursement programs; Insurance information and consultancy; charitable services, namely, providing financial support and financial information to patients and caregivers for obtaining medications and medical treatment; Providing insurance information for patients diagnosed with medical conditions regarding medication access and reimbursement programs and insurance premium and co-pay assistance; providing insurance consulting services to patients diagnosed with medical conditions regarding obtaining approval, authorization, and verification of insurance coverage for treatment, determining existing insurance benefits, and appealing from denial of insurance coverage and acquiring letters of medical necessity for insurance coverage; providing financial co-pay assistance to patients for health care. Training services in the field of medical injection training and pharmaceutical administration training health care, namely, providing health care information by telephone, the internet, and through the distribution of printed matter; charitable services, namely, providing medical information to patients and caregivers for obtaining medications and medical treatment; Providing medical information for patients diagnosed with medical conditions regarding available resources and treatments and steps and actions for wellness, and healthy living; providing medical counseling for patients with medical conditions; medical services, namely, providing medical information through charitable actions in the nature of information for the continuance of medication for those who are underinsured, uninsured, or who have experienced a lapse in insurance coverage; Medical services, namely, providing medical information concerning blood products and concerning pharmaceutical products, including providing information on preparing and self-administering medications. Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support.

Abstract

The present disclosure relates to landing pads, proviruses and methods of use thereof.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

This disclosure relates to an anti-IL-6 antibody (e.g., clazakizumab) and methods for treating end-stage kidney disease (ESKD) with an antibody to interleukin-6 (IL-6). In some embodiments, the anti-IL6 antibody described herein may be used to treat a subject in need thereof, e.g., a human subject diagnosed with ESKD, and/or reduce risks of co-morbidities of ESKD such as cardiovascular death and myocardial infarction.

IPC Classes  ?

• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Goods & Services

Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support

Abstract

The present disclosure relates generally to the manufacturing of gene therapy products, and specifically to methods of producing an enveloped virus in a suspension perfusion cell culture comprising filtering the cell culture fluid through a filter at a harvest rate of at least 2 vessel volumes per day (VVD) to produce a filtered cell culture 5 fluid comprising the enveloped virus, wherein the filter retains cells from the suspension cell line.

IPC Classes  ?

• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

The present disclosure generally relates to the manufacturing of gene therapy products, and specifically to methods of producing an enveloped virus from a stable producer cell clone or a stable producer cell pool overexpressing vesicular stomatitis virus G (VSV-G) in suspension cell culture.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 14/145 - Rhabdoviridae, e.g. rabies virus, Duvenhage virus, Mokola virus or vesicular stomatitis virus
• C12N 15/86 - Viral vectors

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Educational services in the healthcare sector; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Abstract

The present disclosure relates to a method for reducing or hindering development of renal ischemia-reperfusion injury in a subject the method comprising administering an antibody that inhibits granulocyte colony stimulating factor (G-CSF) signaling. In some examples, the ischemia-reperfusion injury is due to or associated with tissue or organ transplantation.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

This disclosure relates generally to vectors, typically viral vectors, useful for the treatment of X-linked agammaglobulinemia (XLA).

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

Provided is a process including: obtaining, with a computer system hosting a data exchange, a plurality of data sets from a plurality of different users of the data exchange; receiving, with the computer system, a query to search among the plurality of data sets, the query specifying a token; determining a group of data sets among the plurality of data sets that is responsive to the query, wherein determining the group of data sets comprises checking titles, tables, field names, and cell values of data sets among the plurality of data sets for use of the token; determining a ranking of members of the group of data sets responsive to the query; and sending in response to the query, summaries of at least some members of the group of data sets with instructions to present the summaries according to the ranking.

IPC Classes  ?

• G06F 16/34 - BrowsingVisualisation therefor
• G06F 16/35 - ClusteringClassification
• G06F 16/24 - Querying

Abstract

Provided is a process including: obtaining, with a computer system hosting a data exchange, a plurality of data sets; receiving from a first user, a selection of a first data set among the plurality of data sets; receiving a message from the first user to be shared with a second user regarding collaboration between the first user and the second user; pre-computing summary statistics or visualizations for each of a plurality of fields of the first data set; causing the message and the summary statistics or visualizations to be presented to the second user in association with the first data set; obtaining another version of the first data set that has undergone revision and logging transformations to the first data set and comments; and causing a listing of versions of the first data set and at least some of the logged changes to be presented.

IPC Classes  ?

• H04L 51/216 - Handling conversation history, e.g. grouping of messages in sessions or threads
• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
• G06F 40/44 - Statistical methods, e.g. probability models
• G06F 40/49 - Data-driven translation using very large corpora, e.g. the web
• H04L 51/02 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages
• H04L 51/234 - Monitoring or handling of messages for tracking messages
• H04L 51/52 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail for supporting social networking services
• G06F 16/21 - Design, administration or maintenance of databases
• G06F 16/248 - Presentation of query results
• G06F 16/26 - Visual data miningBrowsing structured data
• G06F 16/9536 - Search customisation based on social or collaborative filtering
• G06F 16/9538 - Presentation of query results
• G06Q 10/063 - Operations research, analysis or management
• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism

Goods & Services

Training services in the field of medical infusion therapy

Goods & Services

Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support

Goods & Services

Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support

Goods & Services

Providing healthcare education services in the field of education regarding healthcare, namely, conducting educational programs for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; Providing healthcare education services in the field of education regarding healthcare, namely, planning and conducting educational seminars and workshops related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Peer to peer healthcare provider coaching services in the field of healthcare; Medical training and teaching in the field of healthcare; Training services in the field of healthcare; Providing on-line training in the field of healthcare; Providing on-line training in the field of healthcare on a peer to peer basis; Training in the use of healthcare products and pharmaceuticals. Providing educational information about healthcare for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; Providing educational information about healthcare related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals

Goods & Services

Providing healthcare education services in the field of education regarding healthcare, namely, conducting educational programs for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; Providing healthcare education services in the field of education regarding healthcare, namely, planning and conducting educational seminars and workshops related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Peer to peer healthcare provider coaching services in the field of healthcare; Medical training and teaching in the field of healthcare; Training services in the field of healthcare; Providing on-line training in the field of healthcare; Providing on-line training in the field of healthcare on a peer to peer basis; Training in the use of healthcare products and pharmaceuticals. Providing educational information about healthcare for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, its treatment and its impact on patients, patient families, caregivers and healthcare professionals; Providing educational information about healthcare related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals

Goods & Services

Providing healthcare education services, namely, conducting educational programs for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Providing education services in the field of healthcare, namely, planning and conducting educational meetings related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Educational services, namely, providing educational speakers in the field of healthcare; Peer to peer healthcare provider coaching services in the field of healthcare; Medical training and teaching in the field of healthcare; Training services in the field of healthcare; Providing on-line training in the field of healthcare; Providing on-line training in the field of healthcare on a peer to peer basis; Training in the use of healthcare products and pharmaceuticals; Providing educational meeting about healthcare, namely, planning and conducting educational meetings related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals Providing educational information about healthcare, namely, information about medical diseases, illness or conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals

Goods & Services

Providing healthcare education services, namely, conducting educational programs for patients, caregivers and healthcare professionals concerning medical diseases, illness or conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Providing education services in the field of healthcare, namely, planning and conducting educational meetings related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals; Educational services, namely, providing educational speakers in the field of healthcare; Peer to peer healthcare provider coaching services in the field of healthcare; Medical training and teaching in the field of healthcare; Training services in the field of healthcare; Providing on-line training in the field of healthcare; Providing on-line training in the field of healthcare on a peer to peer basis; Training in the use of healthcare products and pharmaceuticals; Providing educational meetings about healthcare, namely, planning and conducting educational meetings related to medical diseases, illnesses and conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals Providing educational information about healthcare, namely, information about medical diseases, illness or conditions, their treatment and their impact on patients, patient families, caregivers and healthcare professionals

Goods & Services

Educational services, namely, conducting classes, seminars, conferences, workshops in the field of iron conditions and illnesses; Publication of scientific papers containing the results of clinical trials in association with iron related diseases, illnesses or conditions; Educational services namely, conducting seminars, conferences, and workshops relating to therapeutic treatments for iron diseases, illnesses and conditions. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials in association with iron conditions; Provision of pharmaceutical information, namely providing scientific research information in the field of pharmaceuticals for treating iron conditions. Provision of pharmaceutical information, namely providing information relating to diagnostic, prophylactic and therapeutic properties of pharmaceuticals in the field of iron diseases, illnesses and conditions; Provision of medical information in the field of iron conditions.

Goods & Services

Information on financial administration of patient reimbursement programs; Insurance information and consultancy; charitable services, namely, providing financial support and financial information to patients and caregivers for obtaining medications and medical treatment; Providing insurance information for patients diagnosed with medical conditions regarding medication access and reimbursement programs and insurance premium and co-pay assistance; providing insurance consulting services to patients diagnosed with medical conditions regarding obtaining approval, authorization, and verification of insurance coverage for treatment, determining existing insurance benefits, and appealing from denial of insurance coverage and acquiring letters of medical necessity for insurance coverage; providing financial co-pay assistance programs to patients. Medical services, namely, providing medical information concerning blood products, providing medical information concerning pharmaceutical products, including providing information on preparing and self-administering medications; health care, namely, providing health care information by telephone, the internet, and through the distribution of printed matter; charitable services, namely, providing medical information to patients and caregivers for obtaining medications and medical treatment; Providing medical information for patients diagnosed with medical conditions regarding available resources and treatments and steps and actions for wellness, physical fitness and healthy living; providing medical counseling, mentoring and guidance for patients with medical conditions; medical services, namely, providing medical information through charitable actions in the nature of information for the continuance of medication for those who are underinsured, uninsured, or who have experienced a lapse in insurance coverage; Providing medical treatment information by text in the field of blood conditions, vaccines, and general health to patients and health care providers; Providing medical treatment information by email in the field of blood conditions, vaccines, and general health to patients and health care providers; providing an Internet website portal featuring medical treatment information for patients and healthcare providers in the field of blood conditions, vaccines and general health

Goods & Services

Medical services, namely, providing medical information concerning blood products, providing medical information concerning pharmaceutical products, and providing information on preparing and self-administering medications; health care, namely, providing health care information by telephone, the internet, and through the distribution of printed matter; charitable services, namely, providing medical information to patients and caregivers for obtaining medications and medical treatment; Providing medical information for patients diagnosed with medical conditions regarding available resources and treatments and steps and actions for wellness, physical fitness and healthy living; providing medical counseling, and guidance for patients with medical conditions; medical services, namely, providing medical information through charitable actions in the nature of providing medical information for the continuance of medication for those who are underinsured, uninsured, or who have experienced a lapse in insurance coverage

Goods & Services

Electronic downloadable publications, namely, booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for healthcare messaging to patients and healthcare providers; Downloadable electronic publications in the nature of booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine Printed publications, namely, booklets, manuals, brochures, letters, informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, letters, informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional, educational, and teaching materials in the field of medicine for use by medical professionals, patients and caregivers

Goods & Services

Electronic downloadable publications, namely, booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for electronic messaging to patients and healthcare providers in the field of healthcare; Downloadable electronic publications in the nature of booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine Printed publications, namely, booklets, manuals, brochures, informational letters, and informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, informational letters, and informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional, educational, and teaching materials in the field of medicine for use by medical professionals, patients and caregivers

Goods & Services

Electronic downloadable publications, namely, booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for healthcare messaging to patients and healthcare providers; Downloadable electronic publications in the nature of booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine Printed publications, namely, booklets, manuals, brochures, letters, informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, letters, informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional, educational, and teaching materials in the field of medicine for use by medical professionals, patients and caregivers

Goods & Services

Electronic downloadable publications, namely, booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for healthcare messaging to patients and healthcare providers; Downloadable electronic publications in the nature of booklets, manuals, brochures, letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine Printed publications, namely, booklets, manuals, brochures, letters, informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, letters, informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional, educational, and teaching materials in the field of medicine for use by medical professionals, patients and caregivers

Goods & Services

Downloadable electronic publications in the nature of booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine; Electronic downloadable publications, namely, booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for electronic messaging to patients and healthcare providers in the field of healthcare Printed publications, namely, booklets, manuals, brochures, informational letters, and informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, informational letters, and informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional and teaching materials in the field of medicine for use by medical professionals, patients and caregivers

Goods & Services

Electronic downloadable publications, namely, booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals in the field of science and medicine; Downloadable software in the nature of a mobile application for healthcare messaging to patients and healthcare providers; Downloadable electronic publications in the nature of booklets, manuals, brochures, informational letters, informational flyers, teaching materials and forms for use by medical professionals, patients and caregivers in the field of medicine; Printed publications, namely, booklets, manuals, brochures, informational letters, informational flyers in the field of medicine; Printed educational publications, namely, booklets, manuals, brochures, informational letters, informational flyers in the fields of medicine and healthcare; Printed instructional, educational, and teaching materials in the field of medicine; Printed instructional, educational, and teaching materials in the field of medicine for use by medical professionals, patients and caregivers.

Goods & Services

Provision of educational services relating to health; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Provision of educational services relating to health; publication of the results of clinical trials; education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; providing information about the results of clinical trials for pharmaceutical products; providing scientific information in the field of medical disorders and their treatment. Provision of pharmaceutical information; provision of medical information.

Abstract

The present disclosure relates generally to the manufacturing of gene therapy products, and specifically to methods of purifying an enveloped virus from a cell culture fluid, comprising an endonuclease and/or anion exchange chromatography.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
• B01D 61/14 - UltrafiltrationMicrofiltration
• C12N 9/22 - Ribonucleases

Goods & Services

Provision of educational services relating to health; publication of the results of clinical trials; education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; providing information about the results of clinical trials for pharmaceutical products; providing scientific information in the field of medical disorders and their treatment. Provision of pharmaceutical information; provision of medical information.

Abstract

Described are human serum albumin (hSA) preparations prepared from human plasma and methods of preparing them. The preparations have an amount of C1 esterase (C1E) inhibitor activity and exhibit stability against serine protease activity.

IPC Classes  ?

• C07K 14/765 - Serum albumin, e.g. HSA
• C07K 1/14 - ExtractionSeparationPurification
• C07K 1/18 - Ion-exchange chromatography

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and research; providing business intelligence services in the fields of medical devices, pharmaceuticals and life sciences from an on-line database; providing business intelligence services in the fields of pharmaceuticals and the life sciences. Custom biomanufacturing, namely, custom manufacturing of pharmaceuticals; custom biomanufacturing of biological preparations; custom manufacture of pharmaceuticals; custom manufacturing services, namely, fractionation services for others; consulting services in the field of custom biomanufacturing of pharmaceuticals, biopharmaceuticals, and fractionation. Scientific, pharmaceutical and medical research and development; biological research; scientific, pharmaceutical, and medical research platform services featuring bioproduction and regulatory pathway services; regulatory and process pathway consulting for clinical manufacturing (term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations); technological consulting for clinical manufacturing; research on the subject of pharmaceuticals; pharmaceutical drug development services; pharmaceutical research and development; pharmaceutical products development; providing medical research information in the field of pharmaceuticals; providing scientific research information in the field of pharmaceuticals; conducting early evaluations in the field of new pharmaceuticals; pharmaceutical product evaluation; research and development services relating to pharmaceuticals and medicines; development of pharmaceutical preparations and medicines; providing medical and scientific research information in the fields of pharmaceuticals; providing medical and scientific research information in the field of pharmaceuticals and clinical trials; consulting services in the field of pharmaceutical and medicinal research; consulting services in the field of pharmaceutical research and development; consulting services in the field of biotechnology. Regulatory compliance consulting in the field of biotechnology; providing information about legal eligibility requirements for government medical and pharmaceutical programs; regulatory compliance consulting in the field of pharmaceuticals.

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and research; providing business intelligence services in the fields of medical devices, pharmaceuticals and life sciences from an on-line database; providing business intelligence services in the fields of pharmaceuticals and the life sciences. Custom biomanufacturing, namely, custom manufacturing of pharmaceuticals; custom biomanufacturing of biological preparations; custom manufacture of pharmaceuticals; custom manufacturing services, namely, fractionation services for others; consulting services in the field of custom biomanufacturing of pharmaceuticals, biopharmaceuticals, and fractionation. Scientific, pharmaceutical and medical research and development; biological research; scientific, pharmaceutical, and medical research platform services featuring bioproduction and regulatory pathway services; regulatory and process pathway consulting for clinical manufacturing (term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations); technological consulting for clinical manufacturing; research on the subject of pharmaceuticals; pharmaceutical drug development services; pharmaceutical research and development; pharmaceutical products development; providing medical research information in the field of pharmaceuticals; providing scientific research information in the field of pharmaceuticals; conducting early evaluations in the field of new pharmaceuticals; pharmaceutical product evaluation; research and development services relating to pharmaceuticals and medicines; development of pharmaceutical preparations and medicines; providing medical and scientific research information in the fields of pharmaceuticals; providing medical and scientific research information in the field of pharmaceuticals and clinical trials; consulting services in the field of pharmaceutical and medicinal research; consulting services in the field of pharmaceutical research and development; consulting services in the field of biotechnology. Regulatory compliance consulting in the field of biotechnology; regulatory compliance consulting in the field of pharmaceuticals; providing information about legal eligibility requirements for government medical and pharmaceutical programs.

Abstract

A wash rack (100) for cleaning filter plates is described. The wash rack comprises a front face spray assembly comprising a plurality of fixed front spray nozzles (110) spaced along a first axis and a rear face spray assembly comprising a plurality of fixed rear spray nozzles (120) along a second axis for directing cleaning fluid spray towards the front and rear surfaces of a filter plate positioned therebetween.

IPC Classes  ?

• B08B 3/02 - Cleaning by the force of jets or sprays
• B01D 41/04 - Regeneration of the filtering material or filter elements outside the filter for liquid or gaseous fluids of rigid self-supporting filtering material

Goods & Services

Provision of educational services relating to health; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials. Provision of pharmaceutical information; Provision of medical information.

Abstract

The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib. In some embodiments, the agent binds to a receptor involved in signalling by at least one of IL-3, G-CSF and GM-CSF. In some embodiments, the agent is a mutein selected from the group consisting of IL-3 muteins, G-CSF muteins and GM-CSF muteins. In some embodiments, the mutein is an IL-3 mutein. In some embodiments, the agent is a soluble receptor which is capable of binding to IL-3.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/19 - CytokinesLymphokinesInterferons
• A61K 38/20 - Interleukins
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

The present invention relates to reconstituted high density lipoprotein (rHDL) formulations comprising an apolipoprotein, a lipid and a lyophilization stabilizer. Said formulations have reduced renal toxicity and good long-term stability, especially in lyophilized form.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• C07K 14/775 - Apolipopeptides

Goods & Services

(1) Provision of educational services, namely, provision of educational programs regarding clinical trials in the field of respiratory and hepatologic diseases and disorders; publication of the results of clinical trials; education services, namely, provision of educational programs regarding clinical trials in the field of therapeutic recreation. (2) Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; providing information about the results of clinical trials for pharmaceutical products; providing scientific information in the field of medical disorders and their treatment. (3) Provision of medical information in the field of pharmaceutical preparations for the treatment of respiratory and hepatologic diseases and disorders.

Abstract

The invention relates to methods for monitoring of parameters in solutions or suspensions and the application of same in methods for purifying solutions comprising human plasma proteins and other components. In one aspect, the invention provides a method for determining the concentration of an analyte in a sample obtained from processing of blood-derived plasma, the method comprising applying a light source to a test sample obtained from processing of blood-derived plasma; measuring inelastic scattering or Raman shift from the test sample, thereby generating test spectra and predictive models, comparing the test spectra with reference spectra obtained from reference samples having known concentrations of the analyte, to determine the concentration of the analyte in the sample.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value

Goods & Services

Pharmaceuticals.

Abstract

The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

Pharmaceutical preparations to treat deficiencies of Alpha One Proteinase inhibitors; Pharmaceutical preparations for transplant conditions; Pharmaceutical preparations for renal conditions; Pharmaceutical preparations for treatment of rejection in transplant recipients; Pharmaceutical preparations for antibody rejection conditions; Pharmaceutical preparations for treatment of emphysema, lung conditions, anti-inflammatory conditions, immunological conditions, and protein deficiencies; Pharmaceutical preparations to prevent and treat graft vs. host disease; Pharmaceutical preparations for Prevention and treatment of Primary Graft Dysfunction.

Goods & Services

Pharmaceutical preparations to treat deficiencies of Alpha One Proteinase inhibitors; Pharmaceutical preparations for transplant conditions; Pharmaceutical preparations for renal conditions; Pharmaceutical preparations for treatment of rejection in transplant recipients; Pharmaceutical preparations for antibody rejection conditions; Pharmaceutical preparations for treatment of emphysema, lung conditions, anti-inflammatory conditions, immunological conditions, and protein deficiencies; Pharmaceutical preparations to prevent and treat graft vs. host disease; Pharmaceutical preparations for prevention and treatment of Primary Graft Dysfunction

Goods & Services

(1) Business intelligence services (2) Electronic data collection for others for business purposes in the fields of medicine, healthcare management and medical research; (3) Custom biomanufacturing of pharmaceuticals; custom manufacture of pharmaceuticals (4) Custom biomanufacturing of biological pharmaceutical preparations; blood plasma fractionation services for others; Consulting services in the field of manufacture of pharmaceuticals, biopharmaceuticals, and blood plasma fractionation services; (5) Scientific research and development in the fields of pharmaceutical; pharmaceutical and medical research and development; biological research in the field of pharmaceuticals and clinical trials; Scientific research in the fields of pharmaceutical featuring bioproduction and regulatory pathway services via online web platform; pharmaceutical and medical research featuring bioproduction and regulatory pathway services via online web platform; Providing medical research information in the field of pharmaceuticals; Research and development in the field of pharmaceuticals and medicines; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of medical biotechnology research and development; (6) Conducting early evaluations in the field of new pharmaceuticals; development of pharmaceutical preparations and medicines; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; providing medical and scientific research information in the field of pharmaceuticals and clinical trials; research on the subject of pharmaceuticals (7) Regulatory compliance consultancy in the field of clinical trials; Providing legal information services about legal eligibility requirements for government medical and pharmaceutical programs; (8) Regulatory compliance consultancy in the field of medical biotechnology; regulatory compliance consultancy in the field of pharmaceuticals

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and research; Providing an on-line database providing business intelligence in the fields of medical devices, pharmaceuticals and life sciences; Providing business intelligence services in the fields of pharmaceuticals and the life sciences; Business consulting and management in the field of clinical trials, namely, clinical data and regulatory submission management on behalf of medical, biopharmaceutical and biotechnology companies to assist them with clinical research, clinical trials and applications for drug approval. Biomanufacturing for others, namely, manufacturing of pharmaceuticals; biomanufacturing of biological preparations; Custom manufacture of pharmaceuticals; Custom manufacturing services, namely, fractionation services for others; Consulting services relating to the aforementioned services; Manufacturing process consulting. Scientific, pharmaceutical and medical research and development; biological research; Scientific, pharmaceutical, and medical research platform services featuring bioproduction and regulatory pathway services; Research on the subject of pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical products development; Providing medical research information in the field of pharmaceuticals; Providing scientific research information in the field of pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; Pharmaceutical product evaluation; Research and development services relating to pharmaceuticals and medicines; Development of pharmaceutical preparations and medicines; Providing medical and scientific research information in the fields of pharmaceuticals; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of biotechnology. Regulatory compliance consulting in the field of biotechnology; Regulatory compliance consulting in the field of pharmaceuticals; Providing information about legal eligibility requirements for government medical and pharmaceutical programs; Advisory services relating to regulatory affairs.

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and related research; Providing an on-line database providing business intelligence in the fields of medical devices, pharmaceuticals and life sciences; Providing business intelligence services in the fields of pharmaceuticals and the life sciences. Biomanufacturing for others, namely, manufacturing of pharmaceuticals; custom biomanufacturing of biological preparations; Custom manufacture of pharmaceuticals; Custom manufacturing services, namely, fractionation services for others. Scientific, pharmaceutical and medical research and development; biological research; Platform as a Service {PAAS} services featuring software for scientific research, pharmaceutical research, and medical research for reviewing, organizing and displaying research information in the field of bioproduction and regulatory pathway services; Research on the subject of pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical products development; Providing medical research information in the field of pharmaceuticals; Providing scientific research information in the field of pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; Pharmaceutical product evaluation; Research and development services relating to pharmaceuticals and medicines; Development of pharmaceutical preparations and medicines; Providing medical and scientific research information in the fields of pharmaceuticals; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of biotechnology; Consulting services in the field of pharmaceuticals, biopharmaceuticals, and fractionation. Regulatory compliance consulting in the field of biotechnology; Regulatory compliance consulting in the field of pharmaceuticals; Providing Information about legal eligibility requirements for government medical and pharmaceutical programs; Regulatory and legal process pathway consulting for clinical manufacturing.

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and related research; Providing an on-line database providing business intelligence in the fields of medical devices, pharmaceuticals and life sciences; Providing business intelligence services in the fields of pharmaceuticals and the life sciences. Biomanufacturing for others, namely, manufacturing of pharmaceuticals; custom biomanufacturing of biological preparations; Custom manufacture of pharmaceuticals; Custom manufacturing services, namely, fractionation services for others. Scientific, pharmaceutical and medical research and development; biological research; Platform as a Service {PAAS} services featuring software for scientific research, pharmaceutical research, and medical research for reviewing, organizing and displaying research information in the field of bioproduction and regulatory pathway services; Research on the subject of pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical products development; Providing medical research information in the field of pharmaceuticals; Providing scientific research information in the field of pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; pharmaceutical product evaluation; Research and development services relating to pharmaceuticals and medicines; development of pharmaceutical preparations and medicines; Providing medical and scientific research information in the fields of pharmaceuticals; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of biotechnology; Consulting services in the field of pharmaceuticals, biopharmaceuticals, and fractionation. Regulatory compliance consulting in the field of biotechnology; Regulatory compliance consulting in the field of pharmaceuticals; Providing Information about legal eligibility requirements for government medical and pharmaceutical programs; Regulatory and legal process pathway consulting for clinical manufacturing.

Goods & Services

(1) Business intelligence services (2) Electronic data collection for others for business purposes in the fields of medicine, healthcare management and medical research; (3) Custom biomanufacturing of biological pharmaceutical preparations; blood plasma fractionation services for others; Consulting services in the field of manufacture of pharmaceuticals, biopharmaceuticals, and blood plasma fractionation services; (4) Custom biomanufacturing of pharmaceuticals; custom manufacture of pharmaceuticals (5) Scientific research and development in the fields of pharmaceutical; pharmaceutical and medical research and development; biological research in the field of pharmaceuticals and clinical trials; Scientific research in the fields of pharmaceutical featuring bioproduction and regulatory pathway services via online web platform; pharmaceutical and medical research featuring bioproduction and regulatory pathway services via online web platform; Providing medical research information in the field of pharmaceuticals; Research and development in the field of pharmaceuticals and medicines; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of medical biotechnology research and development; (6) Conducting early evaluations in the field of new pharmaceuticals; development of pharmaceutical preparations and medicines; pharmaceutical drug development services; pharmaceutical product evaluation; pharmaceutical research and development; providing medical and scientific research information in the field of pharmaceuticals and clinical trials; research on the subject of pharmaceuticals (7) Regulatory compliance consultancy in the field of clinical trials; Providing legal information services about legal eligibility requirements for government medical and pharmaceutical programs; (8) Regulatory compliance consultancy in the field of medical biotechnology; regulatory compliance consultancy in the field of pharmaceuticals

Goods & Services

Electronic data collection and data submission services for business purposes in the fields of medicine, healthcare and research; Providing an on-line database providing business intelligence in the fields of medical devices, pharmaceuticals and life sciences; Providing business intelligence services in the fields of pharmaceuticals and the life sciences; Business consulting and management in the field of clinical trials, namely, clinical data and regulatory submission management on behalf of medical, biopharmaceutical and biotechnology companies to assist them with clinical research, clinical trials and applications for drug approval. Biomanufacturing for others, namely, manufacturing of pharmaceuticals; biomanufacturing of biological preparations; Custom manufacture of pharmaceuticals; Custom manufacturing services, namely, fractionation services for others; Consulting services relating to the aforementioned services; Manufacturing process consulting. Scientific, pharmaceutical and medical research and development; biological research; Scientific, pharmaceutical, and medical research platform services featuring bioproduction and regulatory pathway services; Research on the subject of pharmaceuticals; Pharmaceutical drug development services; Pharmaceutical research and development; Pharmaceutical products development; Providing medical research information in the field of pharmaceuticals; Providing scientific research information in the field of pharmaceuticals; Conducting early evaluations in the field of new pharmaceuticals; Pharmaceutical product evaluation; Research and development services relating to pharmaceuticals and medicines; Development of pharmaceutical preparations and medicines; Providing medical and scientific research information in the fields of pharmaceuticals; Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Consulting services in the field of pharmaceutical and medicinal research; Consulting services in the field of pharmaceutical research and development; Consulting services in the field of biotechnology. Regulatory compliance consulting in the field of biotechnology; Regulatory compliance consulting in the field of pharmaceuticals; Providing information about legal eligibility requirements for government medical and pharmaceutical programs; Advisory services relating to regulatory affairs.

Goods & Services

(1) Downloadable booklets; downloadable digital manuals; downloadable digital newsletters; downloadable instant messaging software (2) Downloadable digital teaching materials for use by medical professionals, patients and caregivers in the field of medicine; downloadable educational materials, namely, brochures, informational flyers, for use by medical professionals, patients and caregivers in the field of medicine; downloadable mobile application software for instant messaging and online chatting for use by patients, patient community members, and healthcare providers; (3) Print letters; printed booklets; printed brochures; printed flyers; printed manuals (4) Printed educational materials for use by medical professionals, patients and caregivers in the field of medicine; (1) Cash card services; charitable services, namely, providing financial support to disadvantaged patients for the purpose of facilitating good health; financial administration of patient reimbursement programs; insurance information and consultancy; providing financial support to patients for the purchase of medications; providing information relating to financial management of patient reimbursement programs; providing insurance information and consultancy (2) Providing financial assistance to patients for the purchase of medications; providing information about charitable services which provide financial assistance programs to patients for the purchase of medications; (3) Nursing services; providing information to patients in the field of administering medications (4) Providing medical information about the analysis and processing of blood plasma and stem cells being medical services; providing health care information by telephone, SMS messaging, the internet, email, and through the distribution of printed matter in the field of patient access to medical treatment services and administering medications; providing medical information to patients and caregivers in the field of patient access to medical treatment services; providing medical information to patients and caregivers in the field of administering medications; providing medical information for patients diagnosed with medical conditions with available resources in the field of patient access to medical treatment services and administering medications; providing medical counseling, mentoring and guidance for patients with medical conditions in the field of patient access to medical treatment services and administering medications; providing information about conducting medical screening and examinations to underserved areas and underserved populations via charitable services; providing medical information by text to patients and health care providers the field of patient access to medical treatment services and administering medications; providing medical information by email to patients and health care providers the field of patient access to medical treatment services and administering medications; providing medical information for patients and healthcare providers in the field of patient access to medical treatment services and administering medications via internet website portal;

Goods & Services

(1) Downloadable booklets; downloadable digital manuals; downloadable digital newsletters; downloadable instant messaging software (2) Downloadable digital teaching materials for use by medical professionals, patients and caregivers in the field of medicine; downloadable educational materials, namely, brochures, informational flyers, for use by medical professionals, patients and caregivers in the field of medicine; downloadable mobile application software for instant messaging and online chatting for use by patients, patient community members, and healthcare providers; (3) Print letters; printed booklets; printed brochures; printed flyers; printed manuals (4) Printed educational materials for use by medical professionals, patients and caregivers in the field of medicine; (1) Cash card services; charitable services, namely, providing financial support to disadvantaged patients for the purpose of facilitating good health; financial administration of patient reimbursement programs; insurance information and consultancy; providing financial support to patients for the purchase of medications; providing information relating to financial management of patient reimbursement programs; providing insurance information and consultancy (2) Providing financial assistance to patients for the purchase of medications; providing information about charitable services which provide financial assistance programs to patients for the purchase of medications; (3) Nursing services; providing information to patients in the field of administering medications (4) Providing medical information about the analysis and processing of blood plasma and stem cells being medical services; providing health care information by telephone, SMS messaging, the internet, email, and through the distribution of printed matter in the field of patient access to medical treatment services and administering medications; providing medical information to patients and caregivers in the field of patient access to medical treatment services; providing medical information to patients and caregivers in the field of administering medications; providing medical information for patients diagnosed with medical conditions with available resources in the field of patient access to medical treatment services and administering medications; providing medical counseling, mentoring and guidance for patients with medical conditions in the field of patient access to medical treatment services and administering medications; providing information about conducting medical screening and examinations to underserved areas and underserved populations via charitable services; providing medical information by text to patients and health care providers the field of patient access to medical treatment services and administering medications; providing medical information by email to patients and health care providers the field of patient access to medical treatment services and administering medications; providing medical information for patients and healthcare providers in the field of patient access to medical treatment services and administering medications via internet website portal;

Abstract

A method including: receiving/retrieving, with one or more physical processors, a data set representing: two or more subjects, at least one numeric attribute with numeric values for the subjects, and at least one categorical attribute with category values for the subjects; defining, with the one or more physical processors, two or more slices for the respective subjects; defining, with the one or more physical processors, numeric-value markers for sectors with respective selected radial lengths/areas representing the numeric values; defining, with the one or more physical processors, category markers for the sectors with respective selected radii, patterns and/or colours representing the category values and mutually distinguishing the categorical values; and rendering, with the one or more physical processors, a radial bar graph from the data set, including: rendering the slices in a circle, rendering the numeric-value markers with the numeric-value radial lengths/areas in respective sectors in the circle, and rendering the category markers with the category radii, the category patterns and/or the category colours around the circle.

IPC Classes  ?

• G06F 3/04845 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range for image manipulation, e.g. dragging, rotation, expansion or change of colour
• G06F 3/04847 - Interaction techniques to control parameter settings, e.g. interaction with sliders or dials
• G06F 16/26 - Visual data miningBrowsing structured data
• G06F 3/04842 - Selection of displayed objects or displayed text elements
• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Abstract

Methods and compositions are disclosed for treating disorders of the contact activation system, comprising the administration of at least one C1-Inhibitor (C1-INH) and at least one Factor XII (FXII) inhibitor.

IPC Classes  ?

• A61K 38/57 - Protease inhibitors from animalsProtease inhibitors from humans
• A61K 31/4365 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
• A61K 31/727 - HeparinHeparan
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07K 16/36 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors

Abstract

This disclosure relates generally to viral vectors useful for gene therapy applications. In particular the disclosure relates to lentiviral vectors, especially lentiviral vectors comprising modified insulator sequences.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/867 - Retroviral vectors

Goods & Services

Provision of educational services relating to health; Publication of the results of clinical trials; Education services relating to therapeutic treatments. Providing medical and scientific research information in the field of pharmaceuticals and clinical trials; Providing information about the results of clinical trials for pharmaceutical products; Providing scientific information in the field of medical disorders and their treatment. Provision of pharmaceutical information; Provision of medical information.

Goods & Services

Business management; Business management advice; Business management analysis; Business management and organization consultancy; Business management consulting; Business management planning; Employment recruiting consultation; Employment recruiting services; Employment staffing consultation services; Providing an on-line searchable database featuring employment opportunities; Providing an on-line searchable database featuring employment opportunities and content about employment; Providing networking opportunities for individuals seeking employment

Goods & Services

Business management; Business management advice; Business management analysis; Business management and organization consultancy; Business management consulting; Business management planning; Employment recruiting consultation; Employment recruiting services; Employment staffing consultation services; Providing an on-line searchable database featuring employment opportunities and content about employment; Providing networking opportunities for individuals seeking employment

Goods & Services

Providing information regarding medical billing support services, namely, medical records coding services for others in the nature of assignment of diagnostic and procedural codes for purposes of reimbursement from insurance Providing information regarding patient medication reimbursement programs and insurance coverage, namely, reimbursement for immunoglobulin purchases Providing medical information regarding immunoglobulin, immunodeficiency disorders, and treatment of same using immunoglobulin; medical consultation directed toward provision of letters of medical necessity or appeal

Goods & Services

providing access to a portal interface for healthcare practitioners and their patients to exchange personal medical information to track their patient support program; providing information on the access to a portal interface for healthcare practitioners and their patients to exchange personal medical information to track their patient support program. Medical services relating to the removal, treatment and processing of human blood; Providing medical support in the monitoring of patients receiving medical treatments; Psychological counselling; Medical counseling services; Advisory services relating to medical services.

Goods & Services

Chemical and biological reagents for industrial use for anti-body screening, blood grouping, and for the typing and detection of specific blood cells, determining the presence of antigens on blood cells, and the detection of relevant compliment components and immunoglobulin subtypes; cell cultures and media, namely, biological preparations for use in cell cultures other than for medical and veterinary use; cell growth media for growing cells for use in scientific research; cell media for growing cells for use in scientific research, namely, for use in the production of pharmaceuticals, vaccines, monoclonal antibodies and recombinant proteins; chemical test kits for the detection of specific blood cells, determining the presence of antigens on blood cells, and the detection of relevant compliment compounds and immunoglobulin subtypes for laboratory or research use; chemical preparations for scientific purposes and for use in industry; Chemical preparations, namely, diagnostic reagents for in vitro use in biochemistry, clinical chemistry and microbiology in the nature of reagents for use in the preparation of in vitro diagnostic kits, for scientific research use; chemical preparations, namely, monoclonal antibodies for use in invitro scientific or research use; chemical preparations for industrial use for anti-body screening, blood grouping, and the typing and detection of specific blood cells; diagnostic and testing agents for scientific or research use, namely, reagents for use in anti-body screening, blood grouping and the typing and detecting of specific blood cells; all of the foregoing are for medical purposes only.

Goods & Services

Charitable services, namely, providing financial assistance to qualifying patients for out of pocket costs and insurance deductible amounts for pharmaceutical preparations for the treatment of blood or bleeding disorders

Abstract

The present disclosure relates to optimised polynucleotides, vectors and methods of use thereof.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Goods & Services

Promoting public awareness of blood conditions, diseases, disorders, and treatment; promoting the interests of patients with blood disorders by means of public advocacy, including through social media and events organized by others; promoting public awareness of the need for influenza immunization and vaccination programs; Business research in the field of public policy concerning policy initiatives for blood conditions and blood related diseases, its treatment and its impact on patients, patient families, caregivers and/or healthcare professionals; promoting the donation of blood and plasma by means of arranging and conducting incentive reward programs; providing public policy information in the field of blood conditions and blood related diseases, its treatment and its impact on patients, patient families, caregivers and/or healthcare professionals. Providing medical information concerning blood products for humans, especially blood proteins for therapeutic use, blood clotting agents and antihemophilic factors, fibrinogen concentrate, and pharmaceutical preparations for the treatment of blood or bleeding disorders and deficiencies of blood coagulation; providing medical information and treatment information in the field of health; medical services, namely, providing medical information concerning blood products, providing medical information concerning health products and services; health care, namely, providing health care information in person, via the internet, and through the distribution of printed matter

Abstract

This disclosure relates to methods for preventing or reducing the risk of development of graft versus host disease (GVHD) in patients receiving hematopoietic cell transplantation (HCT) by particular methods of administering alpha-1 antitrypsin (A1AT or AAT) to patients both prior to and following and HCT procedure. The disclosure also relates to specific methods of treating acute GVHD (aGVHD) after HCT with A1AT.

IPC Classes  ?

• A61K 38/57 - Protease inhibitors from animalsProtease inhibitors from humans
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

The present invention provides a composition for raising an immune response against a tumor. The composition comprises at least one tumor antigen, a saponin-based adjuvant, a TLR ligand and a Flt3 ligand.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

An apolipoprotein formulation is provided at a fixed dosage that is efficacious in the prophylactic and/or therapeutic treatment of diseases or conditions including, but not limited to cardiovascular disease, acute coronary syndrome, atherosclerosis, unstable angina pectoris, and myocardial infarction. More particularly, the fixed dosage apolipoprotein formulation displays relatively reduced inter-patient variability compared to weight-adjusted dosages. Typically, the apolipoprotein formulation is a reconstituted high density lipoprotein formulation comprising ApoA1, one or more lipids such as phosphatidylcholine, sphingomyelin and/or phosphatidylglycerol and, optionally, a detergent such as cholate at a level that does not induce liver toxicity.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 35/14 - BloodArtificial blood
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Reconstituted HDL formulations, methods of treatment comprising same and uses thereof are provided for treating patients after an acute myocardial infarction (MI) event. The reconstituted HDL formulations comprise an apo lipoprotein, a lipid, a detergent and a stabilizer such as sucrose. Treatment of MI patients with repeated infusions of rHDL enhance cholesterol efflux capacity and do not produce significant alterations in liver or kidney function. The MI patient may have normal kidney function or moderate renal impairment.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• A61K 31/727 - HeparinHeparan
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61P 3/06 - Antihyperlipidemics
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present disclosure relates generally to envelope-binding proteins and their use in methods of producing and/or purifying an enveloped virus from cell culture.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

The present disclosure provides a CD131-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds to or specifically binds to CD131 and neutralizes signaling by interleukin (IL) 3, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF), and uses thereof.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

in vivoin vivo transplantation.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

The present disclosure relates generally to methods and compositions for modifying a target sequence in a cell comprising contacting the cell with a gene editing system, a donor template and a second-generation DNA-PK inhibitor. In other embodiments contemplated herein, the present disclosure relates to methods and compositions for modifying a target sequence in a cell, which inhibits non-homologous end joining (NHEJ), resulting in more efficient integration of a donor template into the target sequence.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir