Disclosed herein are compositions, methods of treatment, and uses of inhibitory interneuron precursors, derived from the brain's medial ganglionic eminence, or differentiated from iPSC or ESCs, for the treatment of pre-diabetes or diabetes. In some embodiments, compositions including inhibitory interneuron precursors are transplanted into the arcuate nucleus of the hypothalamus region of the brain, to treat, for example, diabetes, such as, type-2 diabetes. In further embodiments, inhibitory interneuron precursors are used in the manufacture of a medicament for the treatment of diabetes, for example, type-2 diabetes.
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
DIGNITY HEALTH (USA)
Inventor
Saravanan, Nithish Kumar
Nagaraj, Kirthik Roshan
Veluchami, Ezhilan
Sridharan, Ramprakash
Hulson, Tyler
Reynolds, Zane
Chay, Tara
Rhodes, Maura
Abstract
Feedback systems and methods for speech modulation are provided. The feedback system includes a first microphone, a second microphone, a controller, and a biofeedback device. The first microphone captures a user's voice and the second microphone captures ambient noise. The controller processes inputs from the first microphone and the second microphone corresponding to the user's voice and the ambient noise, respectively, and provides a control signal based on the inputs. The biofeedback device receives the control signal from the controller to provide tactile feedback to the user, including a first form of tactile feedback indicating the user is speaking too softly and a second form of tactile feedback indicating the user is speaking too loudly.
A spinal implant is disclosed for engagement to portions of a spinal segment after a laminectomy procedure. The spinal implant includes a first member and a second member in orthogonal relation relative to the first member such that the spinal implant generally defines a t-shape configuration. The spinal implant is formed using biocompatible materials to safely adapt to the surgical area. The spinal implant may include hooks or apertures for engaging with portions of bodily tissue. The spinal implant may be engaged to other spinal implants along the spine using one or more arms of an interconnecting arrangement.
A system provides an electrosurgical tool that delivers an electrosurgical waveform that can be optimized for electrosurgical tasks such as cutting and cauterization of various tissues. The electrosurgical waveform can include a first electrosurgical waveform and a second electrosurgical waveform for simultaneous delivery at respective stimulating electrodes of a stimulating pathway. In some examples, the second electrosurgical waveform is phase-shifted by 180-degrees to minimize deep penetration of current through tissue. The electrosurgical tool provides a relief pathway for further minimization of deep penetration of current through tissue, and can also enable adaptive adjustment of an impedance of the relief pathway, the stimulating pathway, and/or adjustment of one or more parameters of the electrosurgical waveform.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/16 - Indifferent or passive electrodes for grounding
5.
SYSTEMS AND METHODS FOR A SPATIAL QUANTITATIVE AND ANATOMICALLY ACCURATE SURGICAL CORRIDOR MODELING PLATFORM
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
G06T 17/30 - Surface description, e.g. polynomial surface description
G06T 19/00 - Manipulating 3D models or images for computer graphics
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
The Translational Genomics Research Institute (USA)
Inventor
Whitsett, Jr., Timothy G.
Inge, Landon J.
Abstract
Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising contacting the cancer cells with a therapeutically effective amount of a Wee1 inhibitor and a therapeutically effective amount of a second pharmaceutical composition. Embodiments of the invention also provide a method of prognosing or determining the severity of cancer in a subject comprising (a) determining the presence or absence of LKB1 in the cancer cells of the subject; and (b) prognosing the severity of cancer based on the presence of LKB1 deficiency in the cancer cells of the subject.
A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
The multi-way coupler ring assembly is configured to couple a first end of a receiving vessel with a second end of the receiving vessel, and is further configured to couple a donor vessel to the first and second ends of the receiving vessel in a three-way junction. The multi-way coupler ring assembly includes a first receiving coupler ring configured to receive a first receiving vessel and a second receiving coupler ring configured to receive a second receiving vessel and couple with the first receiving coupler ring. The multi-way coupler ring assembly further includes a donor coupler ring configured to receive the donor vessel and couple with the first receiving coupler ring and the second receiving coupler ring. The first receiving coupler ring, the second receiving coupler ring and the donor coupler ring each respectively define a wedged face to enable three-way simultaneous or stepwise coupling with one another.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/00 - Surgical instruments, devices or methods
A multipurpose medical device and a method of performing a medical procedure using the device are provided. The device can include a handle, a body, a suction system, a sensor, and an indicator. The body can be operatively coupled to the handle and can include a lumen extending through a length of the body, and at least a portion of the body is configured to operate as a retractor during the medical procedure. The suction system can include a suction channel disposed within the lumen. The sensor can be coupled to the body and can be configured to sense a retraction force against the body during the medical procedure. The indicator can be configured to provide feedback to the user based on the sensed retraction force.
A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
9.
SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING CHRONIC ORGAN REJECTION
Embodiments of the invention provide a method for diagnosing and treating chronic organ rejection in a subject that has previously received an allographic organ transplant. The method may include (i) receiving a sample from the subject, wherein the subject does not yet experience symptoms of chronic organ rejection and (ii) measuring expression of at least one marker within the sample. In some aspects, the method may also include (iii) treating the subject with at least one therapeutic methodology when the expression of the at least one marker is increased compared to expression of the marker in a control sample.
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
Disclosed herein are methods for treating hot flushes in a subject. In one embodiment, treating hot flushes includes administering to a subject in need of such treatment, a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for amelioration, alleviation, or prevention of the thermal discomfort in hot flushes, comprising: selecting a subject in need of treatment for hot flushes, administering to the subject a therapeutically effective amount of a TRP channel blocker, such as a TRPV1 blocker, or a pharmaceutically acceptable salt thereof.
A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
12.
DIAGNOSTIC OR PREDICTOR OF RELAPSING REMITTING MULTIPLE SCLEROSIS
Provided herein is a method of detecting or predicting a relapse of multiple sclerosis in an individual afflicted with a form of multiple sclerosis, comprising: (a) providing a blood sample of the individual; (b) testing the blood sample to determine a protein activity or protein level, wherein the protein is Factor VIII, von Willebrand factor, or Protein C; and (c) detecting or predicting a relapse of multiple sclerosis in the individual if the protein activity or protein level is elevated compared to the protein activity or protein level in an individual not afflicted with the form of multiple sclerosis and patients' own baseline values. Also provided herein is a method of treating an individual afflicted with multiple sclerosis, who is experiencing a relapse or predicted to experience a relapse, comprising treating the individual by administering a dose of a steroid or anti-coagulation compound effective to alleviate the symptom of multiple sclerosis.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
Arizona Board of Regents on behalf of Arizona State University (USA)
Dignity Health (USA)
Inventor
Sugar, Thomas
Lopez, Luis
Griffith, Lee
Parmentier, Robin
Sridar, Saivimal
Nguyen, Pham Huy
Palmiscno, Jeremy
Meredith, Will
Abstract
A soft wearable medical device may comprise a force actuation system at least partially disposed in a glove assembly. The force actuation system may be a passive or active actuation system. The force actuation system may be configured to adjust a grip of a patient during use of the soft wearable medical device. The soft wearable medical device may further comprise a force indication system including a plurality of force sensors and a light array, each force sensor disposed in a finger of the glove assembly and the light array mounted to the glove assembly.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
G06T 17/30 - Surface description, e.g. polynomial surface description
G06T 19/00 - Manipulating 3D models or images for computer graphics
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
15.
SYSTEMS AND METHODS FOR USING EYE MOVEMENTS TO DETERMINE TRAUMATIC BRAIN INJURY
Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
16.
DRUG DELIVERY COMPOSITION AND METHOD OF FABRICATION
The methods of manufacture of a drug delivery composition. In some aspects, the methods include providing an organic phase, a biologically active ingredient, and an aqueous phase with a desirable pH (e.g., a pH at which the active ingredient has increased solubility in the aqueous phase compared to at neutral pH). After mixing of one or more of the aforementioned components, the resultant mixture is processed to provide the desired drug delivery composition.
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.
Methods of externally reinforcing biological vessels include forming a reinforcing frame around a vessel using a pliable framing material, and applying a solidifying substance to the framing material that transitions the framing material and solidifying substance to a solid state, forming a solid encasement. The framing material can include a plurality of sheets for application in an overlapping piecemeal fashion to a vessel within a surgical corridor. The solidifying substance permeates the reinforcing frame prior to transitioning to the solid state to ensure that the resulting encasement is filly solidified.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
Various embodiments of a rapid-manufacturable and cleanable face covering including a base component that retains a filter material, a cover component that encapsulates the filter material for providing an integrated face shield, and an injection-molded silicon sealant that seals the facial covering against the face. The cover component and base are each vacuum thermoformed for rapid manufacture from polyethylene terephthalate glycol (PETG) or another suitable material.
Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
Izadyyazdanabadi, Mohammadhassan
Preul, Mark C.
Belykh, Evgenii
Yang, Yezhou
Abstract
In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for automatically transforming a digital image into a simulated pathology image are provided. In some embodiments, the method comprises: receiving a content image from an endomicroscopy device; receiving, from a hidden layer of a convolutional neural network (CNN) trained to recognize a multitude of classes of common objects, features indicative of content of the content image; receiving, providing a style reference image to the CNN; receiving, from another hidden layer of the CNN, features indicative of a style of the style reference image; receiving, from the hidden layers of the CNN, features indicative of content and style of a target image; generating a loss value based on the features of the content image, the style reference image, and the target image; minimizing the loss value; and displaying the target image with the minimized loss.
An implantable valve device includes a valve unit having a flow limiter in operative association with a dial for controlling a flow of material through a lumen in communication with the valve unit. The dial includes a dial indicator viewable through cross-sectional imaging for determining and/or otherwise verifying a “pressure setting” of the valve unit. The valve unit can include a housing that encapsulates the dial therein and provides one or more reference indicators that enable a practitioner to determine an orientation of the valve unit and further clarify the position of the dial indicator. The valve unit can be interrogated through conventional non-invasive cross-sectional imaging methods such as ultrasound.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
F21S 2/00 - Systems of lighting devices, not provided for in main groups or , e.g. of modular construction
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
DIGNITY HEALTH (USA)
Inventor
Patwardhan, Amol
Porreca, Frank
Romanovsky, Andrej
Abstract
Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61M 16/01 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes specially adapted for anaesthetising
A61P 43/00 - Drugs for specific purposes, not provided for in groups
24.
SYSTEMS AND METHODS FOR A CONFORMABLE MODULAR ELECTRODE FOR APPLICATION OF AN ALTERNATING ELECTRIC FIELD TO TISSUE
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
Systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy (CLE) are provided. In some embodiments, a method comprises: receiving images captured by a CLE device during brain surgery; providing the images to a convolution neural network (CNN) trained using at least a plurality of images of brain tissue captured by a CLE device and labeled diagnostic or non-diagnostic; receiving an indication, from the CNN, likelihoods that the images are diagnostic images; determining, based on the likelihoods, which of the images are diagnostic images; and in response to determining that an image is a diagnostic image, causing the image to be presented during the brain surgery.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
26.
SYSTEM AND METHOD FOR DETECTION AND MONITORING OF OVER SEDATION TO PREVENT HARM TO PATIENTS
A system and method for identifying over sedation risk factors and generating appropriate alerts for healthcare professionals as a result of an algorithm triggered based whether a calculated over sedation risk score/level for the patient crosses a predefined threshold, and determine whether the patient score is at a low, moderate, or high risk for over sedation. If the patient is at a moderate or high risk, an alert may be triggered and displayed to the healthcare professional, along with data associated with the alert in a synchronized timeline displayed on a user interface.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
27.
METHOD AND APPARATUS FOR A SUCTION CONNECTION SYSTEM
A catheter placement system for drawing a medical tube through a sheath includes a suction generation device and further includes one or more suction adapter devices that enable connection of the suction generation device to the sheath and facilitate insertion of the medical tube into the sheath. The one or more suction adapter devices are operable for lateral removal from the sheath and the medical tube, enabling connection of the medical tube to one or more external devices prior to drawing the medical tube through the sheath.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
28.
Systems and methods of pharmaceutical administration
A device is disclosed that secures a capsule and accommodates puncturing of the capsule and extraction of a medication. The device includes a cavity that receives and secures the capsule. The device includes at least one opening that provides access to the cavity for extraction of the capsule contents.
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
A61J 7/00 - Devices for administering medicines orally, e.g. spoonsPill counting devicesArrangements for time indication or reminder for taking medicine
An anonymous database system includes a plurality of biometric nodes in communication with one another. Each of the plurality of biometric nodes includes a biometric input that receives biometric data from a user. The system also includes at least one central database in communication with the plurality of biometric nodes; and a plurality of institution databases in communication with the plurality of biometric nodes. A first node of the plurality of biometric nodes is configured to receive a message from a second node of the plurality of biometric nodes, the message requesting authorization of data access by the second node. Various embodiments relate to a method for performing an action requiring multiple levels of authentication using an anonymous database system.
Described herein is an incontinence treatment system and method of use. In certain embodiments the incontinence treatment system comprises a rear incontinence member capable of being releasably coupled to a front incontinence member. For example, in one certain embodiment the rear incontinence member includes a rear absorbent region, a rear outer layer coupled to the rear absorbent region, and a plurality of coupling members. The front incontinence member typically includes a front absorbent region and a front outer layer coupled to the front absorbent region, a support material being disposed around at least a portion of the front absorbent region, and one or more coupling regions being configured and arranged to engage at least a portion of the plurality of coupling members to couple the rear incontinence member to the front incontinence member.
A61F 13/495 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the shape specially adapted to be worn around the waist, e.g. diapers, nappies with faecal cavity
A system for inserting a medical tube within the body using a tunneler device enables formation of a tunnel within the body and further enables concurrent insertion of the medical tube within the body as the tunnel is formed, eliminating extra steps required by current technologies for insertion of the medical tube within the body. The tunneler device provides an attachment element that captures the medical tube and further provides a handle slidably mounted along the tunneler device to aid practitioners when inserting the tunneler device into the body. The tunneler device further provides a bend angle to aid practitioners in forming the tunnel past the clavicle of the body. The tunneler device enables practitioners to place medical tubes within the body while reducing time and friction commonly associated with medical tube placement procedures.
Board of Trustees of Michigan State University (USA)
Van Andel Research Institute (USA)
Inventor
Manfredsson, Fredric
Brundin, Lena
Abstract
Compositions for increasing the expression of ACMSD in a target cell and methods of using the compositions to provide a general protective effect in a cell or tissue in a subject, or protect a subject from or treating a disease condition associated with inflammation, oxidative stress, protein aggregation, energy failure, toxic exposure such as exposure to pollutants, or any combination thereof.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A device applies standardized central and peripheral stimuli to a patient for assessment of consciousness. The device is hand-held and includes a first stimulus element for application of peripheral stimuli to a digit (e.g., a finger or a toe) of the patient and a second stimulus element for application of central stimuli to the patient, enabling practitioners to rapidly switch between peripheral and central stimulus application. The device can generate a standardized electrical stimulus, thermal stimulus, and/or mechanical stimulus for application for improved accuracy when assessing consciousness of the patient by methods such as the Glasgow Coma Scale. In another aspect, the device applies standardized stimuli at an appropriate intensity to elicit a response without causing tissue damage.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The present disclosure describes methods of determining a treatment protocol for and/or a prognosis for a subject suspected of or at risk of suffering from a neurologic disease or disorder, including such diseases and disorders that involve motor neuron function such as ALS. The methods comprise detecting the presence of a chitinase protein in a biological sample.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
37.
SYSTEMS AND METHODS FOR 3-DIMENSIONAL ANATOMICAL RECONSTRUCTION USING MONOSCOPIC PHOTOGRAMMETRY
A system applies a monoscopic photogrammetry process that transforms 2D high resolution anatomical images into volumetric surface reconstructions. The system includes a neural network capable of monoscopic depth estimation to generate a set of depth estimation data from a 2D anatomical image. The system then transforms the depth map into a navigable 3D model for display within an extended reality environment.
G06T 7/70 - Determining position or orientation of objects or cameras
G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
G01B 11/02 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness
G01C 11/02 - Picture-taking arrangements specially adapted for photogrammetry or photographic surveying, e.g. controlling overlapping of pictures
G06F 3/04815 - Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
G06T 3/10 - Selection of transformation methods according to the characteristics of the input images
Arizona Board of Regents on Behalf of the University of Arizona (USA)
Dignity Health (USA)
Inventor
Barton, Jennifer Kehlet
Thawani, Nitika
Gelb, Danielle Ann
Cohen, Audrey Tamra
Olivas, Hiram
Mapp, Jacob Emanuel
Zenhausern, Ryan Stephen
Vargas Lopez, Jesus Daniel
Abstract
A system includes a device associated with an endoscopy guided procedure including a housing defining a housing channel with at least a portion of the housing configured for deployment within a cavity. The device further includes a plurality of bodies defining respective channels defined within the housing. The housing defines a longitudinal axis, and the plurality of channels extends throughout the housing around the longitudinal axis. Each of the plurality of channels accommodates selective activation of radiation emittance from a predetermined different position along the housing via one or more radiation elements such that the plurality of channels collectively provides a predetermined spatial distribution of a radiation treatment to a target area along the cavity.
LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Macknik, Stephen L.
Martinez-Conde, Susana
Kapoula, Zoi
Otero-Millan, Jorge
Abstract
A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
Various embodiments of a spinal shield having a shield body including a plurality of lateral extensions configured to be positioned over an exposed spinal canal for establishing a protective barrier around the contents of the exposed spinal canal are disclosed.
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
Electric field therapy requires the strategic delivery of electrical energy to living tissue. Machine learning in the context of a computer-implemented planning environment can be adopted to enhance planning, monitoring, and modulation of this therapy.
A61N 1/40 - Applying electric fields by inductive or capacitive coupling
A61B 5/0536 - Impedance imaging, e.g. by tomography
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation
G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
44.
SYSTEMS AND METHODS FOR A MULTIDIMENSIONAL TRACKING SYSTEM
A multidimensional tracking system incorporates observed positions of objects tracked within various virtual spaces recorded by a plurality of hierarchical tracking systems based on observable positional relationships between the plurality of hierarchical tracking systems. In one embodiment, the multidimensional tracking system displays and records tracking and manipulation of physical objects over time relative to a virtual space. Further, the multidimensional tracking system can evaluate the accuracy of observed positions of objects as well as mappings that translate each virtual space to one another based on observable positional relationships between tracked objects.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/20 - Surgical microscopes characterised by non-optical aspects
45.
CATHETER SYSTEM FOR DRAINING A BODILY FLUID FROM A FLUID SOURCE IN A BODY
A catheter system for draining a bodily fluid from a fluid source in a body of a subject. In one form, the catheter tube has a proximal end and a distal end. The catheter tube includes a drainage lumen that extends from a proximal end opening in the proximal end to a distal end opening in the distal end. The catheter system further includes a fluid sampling component in fluid communication with the distal end opening. In some embodiments, the catheter system includes a one-way check valve. In some embodiments, the catheter system includes a balloon positioned between one or more openings.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
Houlihan, Lena Mary
Naughton, David
Preul, Mark C.
Abstract
Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
Provided herein is a method of detecting or predicting a relapse of multiple sclerosis in an individual afflicted with a form of multiple sclerosis, comprising: (a) providing a blood sample of the individual; (b) testing the blood sample to determine a protein activity or protein level, wherein the protein is Factor VIII, von Willebrand factor, or Protein C; and (c) detecting or predicting a relapse of multiple sclerosis in the individual if the protein activity or protein level is elevated compared to the protein activity or protein level in an individual not afflicted with the form of multiple sclerosis and patients' own baseline values. Also provided herein is a method of treating an individual afflicted with multiple sclerosis, who is experiencing a relapse or predicted to experience a relapse, comprising treating the individual by administering a dose of a steroid or anti-coagulation compound effective to alleviate the symptom of multiple sclerosis.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
Sirianni, Rachael
Cook, Rebecca
Mor, Tsafrir
Blattman, Joseph
Abstract
Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
Compositions and methods for modifying the expression of one or more chitinase proteins in a target cell or tissue type are disclosed. The compositions can be used in methods of treating a disease condition associated with expression of a chitinase protein in a cell or tissue type in a subject in need thereof, such as ALS and PD.
An apparatus for extraction of osseous tissue is disclosed. The apparatus includes a fixed portion and a clamp oriented along a generally central area of the fixed portion. The apparatus includes a first bone cutting device and a second bone cutting device coupled to the fixed portion and oriented around the clamp. The first bone cutting device and the second bone cutting device are coupled to the fixed portion using respective joints that accommodate orientations of the first bone cutting device and the second bone cutting device relative to the fixed portion along different horizontal and vertical axes. The clamp is configured to engage a first bone portion during a surgical procedure. The first bone cutting device and the second bone cutting device are configured to remove a second bone portion.
Various embodiments of a system and associated method for detection of subject activity by processing video and other signals using artificial intelligence are disclosed herein. In particular, a subject monitoring system is disclosed that monitors subjects using a video-capable camera or other suitable video capture device to identify a subject's status of an individual by monitoring subject actions in real-time. The system further monitors other persons in the room with a subject to identify their actions and identities to ensure safety of the subject and facility while preventing confusion of the system as multiple individuals step in and out of frame over the course of the collected video feed. In some embodiments, the system is operable for pose estimation and facial estimation of a subject, care provider, hospital employee or a visitor (collectively, one or more subjects) to recognize actions, emotions and/or identities of each subject to determine if the subject is at risk for an adverse event or to recognize if an adverse event has already happened.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
53.
SYSTEMS AND METHODS FOR A MANUALLY-ACTUATED FASTENER DELIVERY DEVICE
A manually-actuated fastener delivery device for coupling portions of a bodily vessel or other cylindrical structure includes a first clamp portion that carries a first joinable portion of a fastener and a second clamp portion that carries a second joinable portion of the fastener. The fastener delivery device is optimized for micro-surgical applications, and aligns the respective first and second joinable portions of the fastener in a substantially parallel arrangement prior to coupling the first and second joinable portions of the fastener together.
Various embodiments of systems and methods for implantable electrode recording of an alternating electric field are disclosed herein. In particular, the system enables interradial distance-based recording of electric field differential resultant from an applied waveform between various locations within an organic structure. The determination of electric field differential between measuring contacts can enable a practitioner to create a mapping of electric field differential throughout an organic structure that can aid in understanding of how structural and material variability throughout the bodily structure affects electric field propagation through the structure.
Various embodiments of a stereotactic coordinate adjuster system and associated method for positional adjustment of components of a stereotactic system are disclosed herein. The system provides fine adjustment to the stereotactic system by providing form-fitting components that encapsulate components of the stereotactic system and allow for fine positional adjustment of an arc support member and a slide portion of the stereotactic system.
A61B 90/10 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
56.
SYSTEMS AND METHODS FOR NON-INTRUSIVE DECEPTION DETECTION
Arizona Board of Regents on behalf of Arizona State University (USA)
Inventor
Macknik, Stephen L.
Martinez-Conde, Susana
Dale, Richard E.
Besserman, Richard
Mcdaniel, Troy Lee
Abstract
Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
Various exemplary embodiments relate to an anonymous database system. The system includes a plurality of biometric nodes in communication with one another. Each of the plurality of biometric nodes includes a biometric input that receives biometric data from a user. The system also includes at least one central database in communication with the plurality of biometric nodes; and a plurality of institution databases in communication with the plurality of biometric nodes. A first node of the plurality of biometric nodes is configured to receive a message from a second node of the plurality of biometric nodes, the message requesting authorization of data access by the second node. Various embodiments relate to a method for performing an action requiring multiple levels of authentication using an anonymous database system.
A system provides a computer-implemented rendered visualization of a surgeon's path or “roadmap” to a particular target region during a surgical case are disclosed herein. The system includes an approach library in communication with an operating microscope that includes data related to various surgical approach sequences, or “roadmaps” to various target regions. The approach library can be populated by the system and analyzed for variance and trends, as well as provide direct or indirect instruction and guidance through a display member during a surgical case.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/20 - Surgical microscopes characterised by non-optical aspects
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
59.
METHOD OF ENGINEERING AND ISOLATING ADENO-ASSOCIATED VIRUS
Engineered adeno-associated virus (AAV) capsid proteins, each having tropism to a desired target cell or tissue type, are disclosed. Also disclosed are methods of generating the engineered proteins, libraries comprising the engineered proteins, recombinant viruses comprising the engineered proteins, and nucleic acid constructs encoding the engineered proteins.
A system provides an electrosurgical tool that delivers an electrosurgical waveform that can be optimized for electrosurgical tasks such as cutting and cauterization of various tissues. The electrosurgical waveform can include a first electrosurgical waveform and a second electrosurgical waveform for simultaneous delivery at respective stimulating electrodes of a stimulating pathway. In some examples, the second electrosurgical waveform is phase-shifted by 180-degrees to minimize deep penetration of current through tissue. The electrosurgical tool provides a relief pathway for further minimization of deep penetration of current through tissue, and can also enable adaptive adjustment of an impedance of the relief pathway, the stimulating pathway, and/or adjustment of one or more parameters of the electrosurgical waveform.
A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
62.
Systems and methods for microvascular anastomotic coupler ring delivery device
Various embodiments of a device for deep surgical corridor microvascular anastomosis are described herein. A device, comprising: an elongated body; a rod disposed at least partially within the channel of the elongated body; an actuator in association with the elongated body and the rod, wherein the actuator is operable to actuate the rod in a first axial direction; and a pair of coupling arms in association with the distal portion of the rod, wherein the actuator is operable to actuate the rod in a first axial direction such that the pivotable end of each coupling arm of the pair of coupling arms is consequently actuated in the first axial direction such that the pair of coupling arms are parallel with one another in a closed configuration.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
63.
SYSTEMS AND METHODS FOR AN AIRWAY ISOLATION DRAPE APPARATUS
Various embodiments for an airway isolation apparatus having a wire frame that is operable for deploying an isolation drape over a subjects head to protect healthcare and other workers from contagious or otherwise harmful agents are disclosed herein. The drape frame may include a frame base. A frame channel may extend from the frame base and a frame wire may extend through the frame channel A frame opening may be defined by the frame base and the frame channel of the drape frame. A drape may be disposed in the frame opening. Accordingly, the drape frame may be deployed in place over the chest and head of a subject. The drape may cover the subjects head to isolate the mouth and nose of the subject preparatory to accessing these airways for intubation or other procedure.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Dignity Health (USA)
Inventor
Vignola, Claudio
Nethken, Cherrylynne
Palmiscno, Kristin
Mcdaniel, Troy
Joshi, Nikita
Rajeev, Athul
Abstract
Described herein is an assistive medical system that is designed for individuals who are impacted by Midline-Shift Syndrome. Its purpose is to help them reorient and maintain their midline position to improve posture, balance, and other cognitive functions. This is achieved through haptic-feedback mechanisms and visual cues that gently notify the user when their position has deviated from the midline orientation.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
F21S 2/00 - Systems of lighting devices, not provided for in main groups or , e.g. of modular construction
A toothbrush system configured to be coupled to an external suction source. The toothbrush system includes a shaft with a main body with a first end and a second end, and a bristle array and a suction port arranged at the second end. The bristle array and the suction port both extend away from the shaft so that an opening of the suction port is proximal to a distal end of the bristle array. The shaft also includes a stem arranged at the first end. The stem includes a passageway that extends through the main body to provide a fluid connection to the suction port, and is configured to be coupled to the external suction source. Also, the handle is removably coupled to the shaft and includes a drive system operably coupled to the bristle array to actuate motion of the bristle array.
Various embodiments of a system and associated method for whole-blade acquisition and phase correction for fast and robust MR imaging are disclosed herein. In particular, the system enables sampling of odd and even k-space echoes in the same k-space as well as a whole-blade phase correction strategy to achieve improved image quality at an accelerated imaging rate.
G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
68.
Systems and methods for volumetric measurement of maximal allowable working volume within a surgical corridor
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
Houlihan, Lena Mary
Naughton, David
Preul, Mark C.
Abstract
Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
Various embodiments of a hydrophilic catheter introduction system for improved insertion of a shunt catheter are disclosed herein. The catheter introduction system includes an introducer sheath defining an inner surface that includes a hydrophilic coating to aid in passage of a catheter through the introducer sheath. Evaluation of the catheter introduction system with respect to other catheter introduction systems resulted in a significant decrease in average catheter threading time.
Various embodiments of an expandable interbody cage device configured to reduce subsidence into an endplate of a vertebral body by including a plurality of arms that engage the cortical tissue of the vertebral body. The plurality of arms increase the surface area and improve distribution of force, especially around stronger parts of the endplate such as the cortical bone at the rim of the endplate. The expandable interbody cage device maintains a low or slim profile while in a “closed” configuration during insertion between vertebrae and is further operable to laterally expand into an “open” configuration that increases the surface area of the expandable interbody cage device after insertion to securely engage the expandable interbody cage device between the vertebra. The expandable interbody cage device further includes one or more ports and/or cavities in which bone graft material can be disposed within.
Methods of externally reinforcing biological vessels include forming a reinforcing frame around a vessel using a pliable framing material, and applying a solidifying substance to the framing material that transitions the framing material and solidifying substance to a solid state, forming a solid encasement. The framing material can include a plurality of sheets for application in an overlapping piecemeal fashion to a vessel within a surgical corridor. The solidifying substance permeates the reinforcing frame prior to transitioning to the solid state to ensure that the resulting encasement is filly solidified.
A61F 2/945 - Stents retaining their form, i.e. not being deformable, after placement in the predetermined place hardenable, e.g. stents formed in situ
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy (CLE) are provided. In some embodiments, a method comprises: receiving images captured by a CLE device during brain surgery; providing the images to a convolution neural network (CNN) trained using at least a plurality of images of brain tissue captured by a CLE device and labeled diagnostic or non-diagnostic; receiving an indication, from the CNN, likelihoods that the images are diagnostic images; determining, based on the likelihoods, which of the images are diagnostic images; and in response to determining that an image is a diagnostic image, causing the image to be presented during the brain surgery.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
An implantable valve device includes a valve unit having a flow limiter in operative association with a dial for controlling a flow of material through a lumen in communication with the valve unit. The dial includes a dial indicator viewable through cross-sectional imaging for determining and/or otherwise verifying a "pressure setting" of the valve unit. The valve unit can include a housing that encapsulates the dial therein and provides one or more reference indicators that enable a practitioner to determine an orientation of the valve unit and further clarify the position of the dial indicator. The valve unit can be interrogated through conventional non-invasive cross-sectional imaging methods such as ultrasound.
G06Q 10/1093 - Calendar-based scheduling for persons or groups
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
75.
SYSTEMS AND METHODS FOR TREATING LEVODOPA DYSKINESIA, ENHANCING MOTOR BENEFIT, AND DELAYING DISEASE PROGRESSION
Board of Trustees of Michigan State University (USA)
Inventor
Manfredsson, Fredric
Steece-Collier, Kathy
Abstract
Disclosed are systems and compositions for reducing the expression of a CaV1.3 protein in a subject and methods of using the systems for treating dyskinesias induced by DA agonist therapy including levodopa-induced dyskinesias (LID), improving the response to levodopa, and improving the response to levodopa in a subject in need thereof; and slowing progression of Parkinson's disease by providing protection against death or dysfunction of substantia nigra dopamine neurons.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 5/18 - Devices for psychotechnicsTesting reaction times for vehicle drivers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical devices, namely, minimally invasive neurovascular devices, spine technologies being medical apparatus for spinal cord stimulation, spine devices being medical apparatus for spinal cord stimulation and related paraphernalia in the nature of spinal syringes, medical apparatus for spinal disc repair, spiral cross connectors, spinal implants composed of artificial materials for medical conditions that may benefit from a neurological or spinal treatment Educational services, namely, classes, seminars and workshops in the field of neurosciences and delivery of treatments Research services in the field of neuroscience Healthcare services; Healthcare services and particularly clinical health services being healthcare services related to the neurosciences
79.
Systems and methods for treatment of cancer using alternating electric field generation
Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.
Disclosed herein are methods for treating hot flushes in a subject. In one embodiment, treating hot flushes includes administering to a subject in need of such treatment, a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for amelioration, alleviation, or prevention of the thermal discomfort in hot flushes, comprising: selecting a subject in need of treatment for hot flushes, administering to the subject a therapeutically effective amount of a TRP channel blocker, such as a TRPV1 blocker, or a pharmaceutically acceptable salt thereof.
A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
81.
METHOD AND APPARATUS FOR A SUCTION CONNECTION SYSTEM
A catheter placement system for drawing a medical tube through a sheath includes a suction generation device and further includes one or more suction adapter devices that enable connection of the suction generation device to the sheath and facilitate insertion of the medical tube into the sheath. The one or more suction adapter devices are operable for lateral removal from the sheath and the medical tube, enabling connection of the medical tube to one or more external devices prior to drawing the medical tube through the sheath.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61B 17/00 - Surgical instruments, devices or methods
82.
Systems and methods for a stereotactic coordinate adjuster
Various embodiments of a stereotactic coordinate adjuster system and associated method for positional adjustment of components of a stereotactic system are disclosed herein. The system provides fine adjustment to the stereotactic system by providing form-fitting components that encapsulate components of the stereotactic system and allow for fine positional adjustment of an arc support member and a slide portion of the stereotactic system.
A61B 90/10 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
83.
COMPUTER-IMPLEMENTED SYSTEMS AND METHODS FOR COMPUTING PROVIDER ATTRIBUTION
Various embodiments of a computer-implemented system for generating an algorithm configured to compute an attribution output to enhance provider attribution are disclosed.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
Various embodiments of an anatomical model suitable for microsurgical training are disclosed. The anatomical model includes predetermined ergonomic features that accommodate training of a surgical task.
Compounds and berberine compositions containing such compounds that are useful for reducing nicotine dependency. Methods for administering the berberine compositions are also disclosed. The compounds may have a structure according to Formula (I). In Formula (I) R1, R2, R3, R4, and R5 are independently H or D; R6 and R7 are independently hydrogen, deuterium, halogen, C4 to C8 unsubstituted aryl, C4 to C8 substituted aryl, C2 to C6 unsubstituted heterocycle, C2 to C6 substituted heterocycle, C1 to C6 unsubstituted alkyl, C1 to C6 substituted alkyl, C3-C10 unsubstituted cycloalkyl, C3-C10 substituted cycloalkyl, or R6 and R7 are taken together as ═O or ═S; and R8 and R9 are independently selected from a group consisting of methyl, CHF2, and CF3.
C07D 455/03 - Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberineAlkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberineAlkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Various embodiments of a catheter stabilizer that includes a retention body and an occluder for positioning within a burr hole or other channel in the body for occlusion and stabilization of a catheter during a surgical procedure are described herein.
Various embodiments of a system and associated method for a surgical positioning apparatus for supporting a patient in supine, lateral, kidney and prone position are disclosed herein.
Disclosed herein is a wheel shield apparatus that includes a pair of elongated parallel tube members in perpendicular engagement with a pair of short parallel tube members, at least one removable side of the wheel shield apparatus is operable to be temporarily opened or removed such that the wheel shield apparatus may be placed around a wheel of a neurosurgical microscope or some other type of heavy wheeled machinery and the removable side may be placed in a closed position such that the wheel shield surrounds the wheel. Each of the pair of elongated parallel tube members and/or each of the pair of short parallel tube members comprises a cavity configured to receive a ballast material to provide sufficient weight to ensure that the wheel shield apparatus contacts the floor such that cables along the floor are pushed out of the way by the wheel shield apparatus and prevented from being run over while the machinery is being transported.
A system for inserting a medical tube within the body using a tunneler device enables formation of a tunnel within the body and further enables concurrent insertion of the medical tube within the body as the tunnel is formed, eliminating extra steps required by current technologies for insertion of the medical tube within the body. The tunneler device provides an attachment element that captures the medical tube and further provides a handle slidably mounted along the tunneler device to aid practitioners when inserting the tunneler device into the body. The tunneler device further provides a bend angle to aid practitioners in forming the tunnel past the clavicle of the body. The tunneler device enables practitioners to place medical tubes within the body while reducing time and friction commonly associated with medical tube placement procedures.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventor
Macknik, Stephen L.
Martinez-Conde, Susana
Dale, Richard E.
Besserman, Richard
Mcdaniel, Troy Lee
Abstract
Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/18 - Devices for psychotechnicsTesting reaction times for vehicle drivers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
91.
DEVICES AND METHODS FOR APPLYING STIMULATION IN THE ASSESSMENT OF CONSCIOUSNESS
A device applies standardized central and peripheral stimuli to a patient for assessment of consciousness. The device is hand-held and includes a first stimulus element for application of peripheral stimuli to a digit (e.g., a finger or a toe) of the patient and a second stimulus element for application of central stimuli to the patient, enabling practitioners to rapidly switch between peripheral and central stimulus application. The device can generate a standardized electrical stimulus, thermal stimulus, and/or mechanical stimulus for application for improved accuracy when assessing consciousness of the patient by methods such as the Glasgow Coma Scale. In another aspect, the device applies standardized stimuli at an appropriate intensity to elicit a response without causing tissue damage.
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (USA)
VAN ANDEL RESEARCH INSTITUTE (USA)
Inventor
Manfredsson, Fredric
Brundin, Lena
Abstract
Compositions for increasing the expression of ACMSD in a target cell and methods of using the compositions to provide a general protective effect in a cell or tissue in a subject, or protect a subject from or treating a disease condition associated with inflammation, oxidative stress, protein aggregation, energy failure, toxic exposure such as exposure to pollutants, or any combination thereof.
A spinal implant is disclosed for engagement to portions of a spinal segment after a laminectomy procedure. The spinal implant includes a first member and a second member in orthogonal relation relative to the first member such that the spinal implant generally defines a t-shape configuration. The spinal implant is formed using biocompatible materials to safely adapt to the surgical area. The spinal implant may include hooks or apertures for engaging with portions of bodily tissue. The spinal implant may be engaged to other spinal implants along the spine using one or more arms of an interconnecting arrangement.
Disclosed herein is a system/apparatus for storing, use in therapy, and transporting a (bionic) exoskeleton. The apparatus includes a frame comprising a plurality of legs, a seat, and a back which are operable for being moved between one or more configurations. The seat of the frame defines a seat surface configured for engagement with an exoskeleton. Furthermore, the back of the frame is operably engaged with the seat such that the back of the frame may be folded over, into, or extended from the frame to reduce an overall profile size of the apparatus in a collapsed or folded configuration. The apparatus may further include a pair of footrests defined along the legs that rotate in a lateral direction relative to the frame for the patients ease of transition into the exoskeleton. The frame also includes a locking mechanism that aids to from a storage configuration or a ready configuration.
A multidimensional tracking system incorporates observed positions of objects tracked within various virtual spaces recorded by a plurality of hierarchical tracking systems based on observable positional relationships between the plurality of hierarchical tracking systems. In one embodiment, the multidimensional tracking system displays and records tracking and manipulation of physical objects over time relative to a virtual space. Further, the multidimensional tracking system can evaluate the accuracy of observed positions of objects as well as mappings that translate each virtual space to one another based on observable positional relationships between tracked objects.
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
DIGNITY HEALTH (USA)
Inventor
Barton, Jennifer Kehlet
Thawani, Nitika
Gelb, Danielle Ann
Cohen, Audrey Tamra
Olivas, Hiram
Mapp, Jacob Emanuel
Zenhausern, Ryan Stephen
Vargas Lopez, Jesus Daniel
Abstract
A system includes a device associated with an endoscopy guided procedure including a housing defining a housing channel with at least a portion of the housing configured for deployment within a cavity. The device further includes a plurality of bodies defining respective channels defined within the housing. The housing defines a longitudinal axis, and the plurality of channels extends throughout the housing around the longitudinal axis. Each of the plurality of channels accommodates selective activation of radiation emittance from a predetermined different position along the housing via one or more radiation elements such that the plurality of channels collectively provides a predetermined spatial distribution of a radiation treatment to a target area along the cavity.
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
Electric field therapy requires the strategic delivery of electrical energy to living tissue. Machine learning in the context of a computer-implemented planning environment can be adopted to enhance planning, monitoring, and modulation of this therapy.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61N 1/40 - Applying electric fields by inductive or capacitive coupling
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
99.
SYSTEMS AND METHODS FOR IMPLANTABLE ELECTRODES WITH FEEDBACK FOR APPLICATION OF ELECTRIC FIELD THERAPY WITHIN THE BODY
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
A method for bending a surgical rod using an automated bending system includes receiving an indication of a plurality of line segments defined on the rod and an indication of an angle measurement to be formed between at least two adjacent ones of the plurality of line segments. Bending parameters to perform on the rod to form the angle measurement between the at least two adjacent ones of the plurality of line segments are determined and operation of the automated bending system is controlled using the bending parameters to create an angle having the angle measurement between the at least two adjacent ones of the plurality of line segments.
A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
B21D 7/08 - Bending rods, profiles, or tubes by passing between rollers or through a curved die
B21D 7/12 - Bending rods, profiles, or tubes with programme control
B21D 7/14 - Bending rods, profiles, or tubes combined with measuring of bends or lengths
B21D 43/00 - Feeding, positioning or storing devices combined with, or arranged in, or specially adapted for use in connection with, apparatus for working or processing sheet metal, metal tubes or metal profilesAssociations therewith of cutting devices
B21F 1/00 - Bending wire other than coilingStraightening wire
B21F 45/00 - Wire-working in the manufacture of other particular articles
