Disclosed herein are compositions, methods of treatment, and uses of inhibitory interneuron precursors, derived from the brain's medial ganglionic eminence, or differentiated from iPSC or ESCs, for the treatment of pre-diabetes or diabetes. In some embodiments, compositions including inhibitory interneuron precursors are transplanted into the arcuate nucleus of the hypothalamus region of the brain, to treat, for example, diabetes, such as, type-2 diabetes. In further embodiments, inhibitory interneuron precursors are used in the manufacture of a medicament for the treatment of diabetes, for example, type-2 diabetes.
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
DIGNITY HEALTH (USA)
Inventeur(s)
Saravanan, Nithish Kumar
Nagaraj, Kirthik Roshan
Veluchami, Ezhilan
Sridharan, Ramprakash
Hulson, Tyler
Reynolds, Zane
Chay, Tara
Rhodes, Maura
Abrégé
Feedback systems and methods for speech modulation are provided. The feedback system includes a first microphone, a second microphone, a controller, and a biofeedback device. The first microphone captures a user's voice and the second microphone captures ambient noise. The controller processes inputs from the first microphone and the second microphone corresponding to the user's voice and the ambient noise, respectively, and provides a control signal based on the inputs. The biofeedback device receives the control signal from the controller to provide tactile feedback to the user, including a first form of tactile feedback indicating the user is speaking too softly and a second form of tactile feedback indicating the user is speaking too loudly.
A spinal implant is disclosed for engagement to portions of a spinal segment after a laminectomy procedure. The spinal implant includes a first member and a second member in orthogonal relation relative to the first member such that the spinal implant generally defines a t-shape configuration. The spinal implant is formed using biocompatible materials to safely adapt to the surgical area. The spinal implant may include hooks or apertures for engaging with portions of bodily tissue. The spinal implant may be engaged to other spinal implants along the spine using one or more arms of an interconnecting arrangement.
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
A system provides an electrosurgical tool that delivers an electrosurgical waveform that can be optimized for electrosurgical tasks such as cutting and cauterization of various tissues. The electrosurgical waveform can include a first electrosurgical waveform and a second electrosurgical waveform for simultaneous delivery at respective stimulating electrodes of a stimulating pathway. In some examples, the second electrosurgical waveform is phase-shifted by 180-degrees to minimize deep penetration of current through tissue. The electrosurgical tool provides a relief pathway for further minimization of deep penetration of current through tissue, and can also enable adaptive adjustment of an impedance of the relief pathway, the stimulating pathway, and/or adjustment of one or more parameters of the electrosurgical waveform.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/16 - Électrodes neutres ou passives pour mise à la terre
5.
SYSTEMS AND METHODS FOR A SPATIAL QUANTITATIVE AND ANATOMICALLY ACCURATE SURGICAL CORRIDOR MODELING PLATFORM
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
G06T 17/30 - Description de surfaces, p. ex. description de surfaces polynomiales
G06T 19/00 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
The Translational Genomics Research Institute (USA)
Inventeur(s)
Whitsett, Jr., Timothy G.
Inge, Landon J.
Abrégé
Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising contacting the cancer cells with a therapeutically effective amount of a Wee1 inhibitor and a therapeutically effective amount of a second pharmaceutical composition. Embodiments of the invention also provide a method of prognosing or determining the severity of cancer in a subject comprising (a) determining the presence or absence of LKB1 in the cancer cells of the subject; and (b) prognosing the severity of cancer based on the presence of LKB1 deficiency in the cancer cells of the subject.
A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
The multi-way coupler ring assembly is configured to couple a first end of a receiving vessel with a second end of the receiving vessel, and is further configured to couple a donor vessel to the first and second ends of the receiving vessel in a three-way junction. The multi-way coupler ring assembly includes a first receiving coupler ring configured to receive a first receiving vessel and a second receiving coupler ring configured to receive a second receiving vessel and couple with the first receiving coupler ring. The multi-way coupler ring assembly further includes a donor coupler ring configured to receive the donor vessel and couple with the first receiving coupler ring and the second receiving coupler ring. The first receiving coupler ring, the second receiving coupler ring and the donor coupler ring each respectively define a wedged face to enable three-way simultaneous or stepwise coupling with one another.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour réaliser l'anastomoseBoutons pour anastomose
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A multipurpose medical device and a method of performing a medical procedure using the device are provided. The device can include a handle, a body, a suction system, a sensor, and an indicator. The body can be operatively coupled to the handle and can include a lumen extending through a length of the body, and at least a portion of the body is configured to operate as a retractor during the medical procedure. The suction system can include a suction channel disposed within the lumen. The sensor can be coupled to the body and can be configured to sense a retraction force against the body during the medical procedure. The indicator can be configured to provide feedback to the user based on the sensed retraction force.
A61B 17/02 - Instruments, dispositifs ou procédés chirurgicaux pour maintenir les blessures ouvertes, p. ex. rétracteursÉcarteurs
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
9.
SYSTEMS AND METHODS FOR DIAGNOSING AND TREATING CHRONIC ORGAN REJECTION
Embodiments of the invention provide a method for diagnosing and treating chronic organ rejection in a subject that has previously received an allographic organ transplant. The method may include (i) receiving a sample from the subject, wherein the subject does not yet experience symptoms of chronic organ rejection and (ii) measuring expression of at least one marker within the sample. In some aspects, the method may also include (iii) treating the subject with at least one therapeutic methodology when the expression of the at least one marker is increased compared to expression of the marker in a control sample.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
Disclosed herein are methods for treating hot flushes in a subject. In one embodiment, treating hot flushes includes administering to a subject in need of such treatment, a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for amelioration, alleviation, or prevention of the thermal discomfort in hot flushes, comprising: selecting a subject in need of treatment for hot flushes, administering to the subject a therapeutically effective amount of a TRP channel blocker, such as a TRPV1 blocker, or a pharmaceutically acceptable salt thereof.
A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
12.
DIAGNOSTIC OR PREDICTOR OF RELAPSING REMITTING MULTIPLE SCLEROSIS
Provided herein is a method of detecting or predicting a relapse of multiple sclerosis in an individual afflicted with a form of multiple sclerosis, comprising: (a) providing a blood sample of the individual; (b) testing the blood sample to determine a protein activity or protein level, wherein the protein is Factor VIII, von Willebrand factor, or Protein C; and (c) detecting or predicting a relapse of multiple sclerosis in the individual if the protein activity or protein level is elevated compared to the protein activity or protein level in an individual not afflicted with the form of multiple sclerosis and patients' own baseline values. Also provided herein is a method of treating an individual afflicted with multiple sclerosis, who is experiencing a relapse or predicted to experience a relapse, comprising treating the individual by administering a dose of a steroid or anti-coagulation compound effective to alleviate the symptom of multiple sclerosis.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
13.
ASSISTIVE DEVICE FOR PATIENTS WITH SOMATOSENSATION DEFICIENCY
Arizona Board of Regents on behalf of Arizona State University (USA)
Dignity Health (USA)
Inventeur(s)
Sugar, Thomas
Lopez, Luis
Griffith, Lee
Parmentier, Robin
Sridar, Saivimal
Nguyen, Pham Huy
Palmiscno, Jeremy
Meredith, Will
Abrégé
A soft wearable medical device may comprise a force actuation system at least partially disposed in a glove assembly. The force actuation system may be a passive or active actuation system. The force actuation system may be configured to adjust a grip of a patient during use of the soft wearable medical device. The soft wearable medical device may further comprise a force indication system including a plurality of force sensors and a light array, each force sensor disposed in a finger of the glove assembly and the light array mounted to the glove assembly.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
G06T 17/30 - Description de surfaces, p. ex. description de surfaces polynomiales
G06T 19/00 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
15.
SYSTEMS AND METHODS FOR USING EYE MOVEMENTS TO DETERMINE TRAUMATIC BRAIN INJURY
Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
16.
DRUG DELIVERY COMPOSITION AND METHOD OF FABRICATION
The methods of manufacture of a drug delivery composition. In some aspects, the methods include providing an organic phase, a biologically active ingredient, and an aqueous phase with a desirable pH (e.g., a pH at which the active ingredient has increased solubility in the aqueous phase compared to at neutral pH). After mixing of one or more of the aforementioned components, the resultant mixture is processed to provide the desired drug delivery composition.
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
18.
SYSTEMS AND METHODS FOR REINFORCEMENT OF BIOLOGICAL CHANNELS
Methods of externally reinforcing biological vessels include forming a reinforcing frame around a vessel using a pliable framing material, and applying a solidifying substance to the framing material that transitions the framing material and solidifying substance to a solid state, forming a solid encasement. The framing material can include a plurality of sheets for application in an overlapping piecemeal fashion to a vessel within a surgical corridor. The solidifying substance permeates the reinforcing frame prior to transitioning to the solid state to ensure that the resulting encasement is filly solidified.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
Various embodiments of a rapid-manufacturable and cleanable face covering including a base component that retains a filter material, a cover component that encapsulates the filter material for providing an integrated face shield, and an injection-molded silicon sealant that seals the facial covering against the face. The cover component and base are each vacuum thermoformed for rapid manufacture from polyethylene terephthalate glycol (PETG) or another suitable material.
Arizona Board of Regents on behalf of Arizona State University (USA)
Inventeur(s)
Izadyyazdanabadi, Mohammadhassan
Preul, Mark C.
Belykh, Evgenii
Yang, Yezhou
Abrégé
In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for automatically transforming a digital image into a simulated pathology image are provided. In some embodiments, the method comprises: receiving a content image from an endomicroscopy device; receiving, from a hidden layer of a convolutional neural network (CNN) trained to recognize a multitude of classes of common objects, features indicative of content of the content image; receiving, providing a style reference image to the CNN; receiving, from another hidden layer of the CNN, features indicative of a style of the style reference image; receiving, from the hidden layers of the CNN, features indicative of content and style of a target image; generating a loss value based on the features of the content image, the style reference image, and the target image; minimizing the loss value; and displaying the target image with the minimized loss.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
An implantable valve device includes a valve unit having a flow limiter in operative association with a dial for controlling a flow of material through a lumen in communication with the valve unit. The dial includes a dial indicator viewable through cross-sectional imaging for determining and/or otherwise verifying a “pressure setting” of the valve unit. The valve unit can include a housing that encapsulates the dial therein and provides one or more reference indicators that enable a practitioner to determine an orientation of the valve unit and further clarify the position of the dial indicator. The valve unit can be interrogated through conventional non-invasive cross-sectional imaging methods such as ultrasound.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
F21S 2/00 - Systèmes de dispositifs d'éclairage non prévus dans les groupes principaux ou , p. ex. à construction modulaire
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
DIGNITY HEALTH (USA)
Inventeur(s)
Patwardhan, Amol
Porreca, Frank
Romanovsky, Andrej
Abrégé
Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p. ex. indazole
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61M 16/01 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux spécialement conçus pour l'anesthésie
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
24.
SYSTEMS AND METHODS FOR A CONFORMABLE MODULAR ELECTRODE FOR APPLICATION OF AN ALTERNATING ELECTRIC FIELD TO TISSUE
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
Systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy (CLE) are provided. In some embodiments, a method comprises: receiving images captured by a CLE device during brain surgery; providing the images to a convolution neural network (CNN) trained using at least a plurality of images of brain tissue captured by a CLE device and labeled diagnostic or non-diagnostic; receiving an indication, from the CNN, likelihoods that the images are diagnostic images; determining, based on the likelihoods, which of the images are diagnostic images; and in response to determining that an image is a diagnostic image, causing the image to be presented during the brain surgery.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
26.
SYSTEM AND METHOD FOR DETECTION AND MONITORING OF OVER SEDATION TO PREVENT HARM TO PATIENTS
A system and method for identifying over sedation risk factors and generating appropriate alerts for healthcare professionals as a result of an algorithm triggered based whether a calculated over sedation risk score/level for the patient crosses a predefined threshold, and determine whether the patient score is at a low, moderate, or high risk for over sedation. If the patient is at a moderate or high risk, an alert may be triggered and displayed to the healthcare professional, along with data associated with the alert in a synchronized timeline displayed on a user interface.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
27.
METHOD AND APPARATUS FOR A SUCTION CONNECTION SYSTEM
A catheter placement system for drawing a medical tube through a sheath includes a suction generation device and further includes one or more suction adapter devices that enable connection of the suction generation device to the sheath and facilitate insertion of the medical tube into the sheath. The one or more suction adapter devices are operable for lateral removal from the sheath and the medical tube, enabling connection of the medical tube to one or more external devices prior to drawing the medical tube through the sheath.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
28.
Systems and methods of pharmaceutical administration
A device is disclosed that secures a capsule and accommodates puncturing of the capsule and extraction of a medication. The device includes a cavity that receives and secures the capsule. The device includes at least one opening that provides access to the cavity for extraction of the capsule contents.
A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
A61J 7/00 - Dispositifs pour administrer les médicaments par voie buccale, p. ex. cuillèresDispositifs pour compter les pilulesDispositions pour l'indication ou le rappel du moment où l'on doit prendre des médicaments
An anonymous database system includes a plurality of biometric nodes in communication with one another. Each of the plurality of biometric nodes includes a biometric input that receives biometric data from a user. The system also includes at least one central database in communication with the plurality of biometric nodes; and a plurality of institution databases in communication with the plurality of biometric nodes. A first node of the plurality of biometric nodes is configured to receive a message from a second node of the plurality of biometric nodes, the message requesting authorization of data access by the second node. Various embodiments relate to a method for performing an action requiring multiple levels of authentication using an anonymous database system.
Described herein is an incontinence treatment system and method of use. In certain embodiments the incontinence treatment system comprises a rear incontinence member capable of being releasably coupled to a front incontinence member. For example, in one certain embodiment the rear incontinence member includes a rear absorbent region, a rear outer layer coupled to the rear absorbent region, and a plurality of coupling members. The front incontinence member typically includes a front absorbent region and a front outer layer coupled to the front absorbent region, a support material being disposed around at least a portion of the front absorbent region, and one or more coupling regions being configured and arranged to engage at least a portion of the plurality of coupling members to couple the rear incontinence member to the front incontinence member.
A61F 13/495 - Garnitures absorbantes, p. ex. serviettes ou tampons hygiéniques pour application externe ou interne au corpsMoyens pour les maintenir en place ou les fixerApplicateurs de tampons caractérisées par la forme spécialement adaptées pour être portées autour de la taille, p. ex. couches-culottes avec une cavité fécale
A61F 13/56 - Moyens pour les maintenir en place ou les fixer
A system for inserting a medical tube within the body using a tunneler device enables formation of a tunnel within the body and further enables concurrent insertion of the medical tube within the body as the tunnel is formed, eliminating extra steps required by current technologies for insertion of the medical tube within the body. The tunneler device provides an attachment element that captures the medical tube and further provides a handle slidably mounted along the tunneler device to aid practitioners when inserting the tunneler device into the body. The tunneler device further provides a bend angle to aid practitioners in forming the tunnel past the clavicle of the body. The tunneler device enables practitioners to place medical tubes within the body while reducing time and friction commonly associated with medical tube placement procedures.
Board of Trustees of Michigan State University (USA)
Van Andel Research Institute (USA)
Inventeur(s)
Manfredsson, Fredric
Brundin, Lena
Abrégé
Compositions for increasing the expression of ACMSD in a target cell and methods of using the compositions to provide a general protective effect in a cell or tissue in a subject, or protect a subject from or treating a disease condition associated with inflammation, oxidative stress, protein aggregation, energy failure, toxic exposure such as exposure to pollutants, or any combination thereof.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A device applies standardized central and peripheral stimuli to a patient for assessment of consciousness. The device is hand-held and includes a first stimulus element for application of peripheral stimuli to a digit (e.g., a finger or a toe) of the patient and a second stimulus element for application of central stimuli to the patient, enabling practitioners to rapidly switch between peripheral and central stimulus application. The device can generate a standardized electrical stimulus, thermal stimulus, and/or mechanical stimulus for application for improved accuracy when assessing consciousness of the patient by methods such as the Glasgow Coma Scale. In another aspect, the device applies standardized stimuli at an appropriate intensity to elicit a response without causing tissue damage.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The present disclosure describes methods of determining a treatment protocol for and/or a prognosis for a subject suspected of or at risk of suffering from a neurologic disease or disorder, including such diseases and disorders that involve motor neuron function such as ALS. The methods comprise detecting the presence of a chitinase protein in a biological sample.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour réaliser l'anastomoseBoutons pour anastomose
37.
SYSTEMS AND METHODS FOR 3-DIMENSIONAL ANATOMICAL RECONSTRUCTION USING MONOSCOPIC PHOTOGRAMMETRY
A system applies a monoscopic photogrammetry process that transforms 2D high resolution anatomical images into volumetric surface reconstructions. The system includes a neural network capable of monoscopic depth estimation to generate a set of depth estimation data from a 2D anatomical image. The system then transforms the depth map into a navigable 3D model for display within an extended reality environment.
A61B 5/107 - Mesure de dimensions corporelles, p. ex. la taille du corps entier ou de parties de celui-ci
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
G06T 7/50 - Récupération de la profondeur ou de la forme
G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
G01B 11/02 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur
G01C 11/02 - Dispositions de prises de vues spécialement adaptées pour la photogrammétrie ou les levers photographiques, p. ex. pour commander le recouvrement des photos
G06F 3/04815 - Interaction s’effectuant dans un environnement basé sur des métaphores ou des objets avec un affichage tridimensionnel, p. ex. modification du point de vue de l’utilisateur par rapport à l’environnement ou l’objet
G06T 3/10 - Sélection de méthodes de transformation en fonction de caractéristiques des images d’entrée
Arizona Board of Regents on Behalf of the University of Arizona (USA)
Dignity Health (USA)
Inventeur(s)
Barton, Jennifer Kehlet
Thawani, Nitika
Gelb, Danielle Ann
Cohen, Audrey Tamra
Olivas, Hiram
Mapp, Jacob Emanuel
Zenhausern, Ryan Stephen
Vargas Lopez, Jesus Daniel
Abrégé
A system includes a device associated with an endoscopy guided procedure including a housing defining a housing channel with at least a portion of the housing configured for deployment within a cavity. The device further includes a plurality of bodies defining respective channels defined within the housing. The housing defines a longitudinal axis, and the plurality of channels extends throughout the housing around the longitudinal axis. Each of the plurality of channels accommodates selective activation of radiation emittance from a predetermined different position along the housing via one or more radiation elements such that the plurality of channels collectively provides a predetermined spatial distribution of a radiation treatment to a target area along the cavity.
LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Macknik, Stephen L.
Martinez-Conde, Susana
Kapoula, Zoi
Otero-Millan, Jorge
Abrégé
A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
Various embodiments of a spinal shield having a shield body including a plurality of lateral extensions configured to be positioned over an exposed spinal canal for establishing a protective barrier around the contents of the exposed spinal canal are disclosed.
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
Electric field therapy requires the strategic delivery of electrical energy to living tissue. Machine learning in the context of a computer-implemented planning environment can be adopted to enhance planning, monitoring, and modulation of this therapy.
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61B 5/0536 - Imagerie par impédance, p. ex. par tomographie
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G06T 17/20 - Description filaire, p. ex. polygonalisation ou tessellation
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
44.
SYSTEMS AND METHODS FOR A MULTIDIMENSIONAL TRACKING SYSTEM
A multidimensional tracking system incorporates observed positions of objects tracked within various virtual spaces recorded by a plurality of hierarchical tracking systems based on observable positional relationships between the plurality of hierarchical tracking systems. In one embodiment, the multidimensional tracking system displays and records tracking and manipulation of physical objects over time relative to a virtual space. Further, the multidimensional tracking system can evaluate the accuracy of observed positions of objects as well as mappings that translate each virtual space to one another based on observable positional relationships between tracked objects.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/20 - Microscopes chirurgicaux caractérisés par des aspects non optiques
45.
CATHETER SYSTEM FOR DRAINING A BODILY FLUID FROM A FLUID SOURCE IN A BODY
A catheter system for draining a bodily fluid from a fluid source in a body of a subject. In one form, the catheter tube has a proximal end and a distal end. The catheter tube includes a drainage lumen that extends from a proximal end opening in the proximal end to a distal end opening in the distal end. The catheter system further includes a fluid sampling component in fluid communication with the distal end opening. In some embodiments, the catheter system includes a one-way check valve. In some embodiments, the catheter system includes a balloon positioned between one or more openings.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventeur(s)
Houlihan, Lena Mary
Naughton, David
Preul, Mark C.
Abrégé
Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
Provided herein is a method of detecting or predicting a relapse of multiple sclerosis in an individual afflicted with a form of multiple sclerosis, comprising: (a) providing a blood sample of the individual; (b) testing the blood sample to determine a protein activity or protein level, wherein the protein is Factor VIII, von Willebrand factor, or Protein C; and (c) detecting or predicting a relapse of multiple sclerosis in the individual if the protein activity or protein level is elevated compared to the protein activity or protein level in an individual not afflicted with the form of multiple sclerosis and patients' own baseline values. Also provided herein is a method of treating an individual afflicted with multiple sclerosis, who is experiencing a relapse or predicted to experience a relapse, comprising treating the individual by administering a dose of a steroid or anti-coagulation compound effective to alleviate the symptom of multiple sclerosis.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
G01N 33/86 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir le temps de coagulation du sang
48.
ANTIBODY FUSION PROTEIN AND RELATED COMPOSITIONS FOR TARGETING CANCER
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventeur(s)
Sirianni, Rachael
Cook, Rebecca
Mor, Tsafrir
Blattman, Joseph
Abrégé
Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
Compositions and methods for modifying the expression of one or more chitinase proteins in a target cell or tissue type are disclosed. The compositions can be used in methods of treating a disease condition associated with expression of a chitinase protein in a cell or tissue type in a subject in need thereof, such as ALS and PD.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 9/42 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2) agissant sur les liaisons bêta-glucosidiques-1, 4, p. ex. cellulase
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
51.
Apparatus for incision and removal of osseous tissue and methods thereof
An apparatus for extraction of osseous tissue is disclosed. The apparatus includes a fixed portion and a clamp oriented along a generally central area of the fixed portion. The apparatus includes a first bone cutting device and a second bone cutting device coupled to the fixed portion and oriented around the clamp. The first bone cutting device and the second bone cutting device are coupled to the fixed portion using respective joints that accommodate orientations of the first bone cutting device and the second bone cutting device relative to the fixed portion along different horizontal and vertical axes. The clamp is configured to engage a first bone portion during a surgical procedure. The first bone cutting device and the second bone cutting device are configured to remove a second bone portion.
Various embodiments of a system and associated method for detection of subject activity by processing video and other signals using artificial intelligence are disclosed herein. In particular, a subject monitoring system is disclosed that monitors subjects using a video-capable camera or other suitable video capture device to identify a subject's status of an individual by monitoring subject actions in real-time. The system further monitors other persons in the room with a subject to identify their actions and identities to ensure safety of the subject and facility while preventing confusion of the system as multiple individuals step in and out of frame over the course of the collected video feed. In some embodiments, the system is operable for pose estimation and facial estimation of a subject, care provider, hospital employee or a visitor (collectively, one or more subjects) to recognize actions, emotions and/or identities of each subject to determine if the subject is at risk for an adverse event or to recognize if an adverse event has already happened.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
53.
SYSTEMS AND METHODS FOR A MANUALLY-ACTUATED FASTENER DELIVERY DEVICE
A manually-actuated fastener delivery device for coupling portions of a bodily vessel or other cylindrical structure includes a first clamp portion that carries a first joinable portion of a fastener and a second clamp portion that carries a second joinable portion of the fastener. The fastener delivery device is optimized for micro-surgical applications, and aligns the respective first and second joinable portions of the fastener in a substantially parallel arrangement prior to coupling the first and second joinable portions of the fastener together.
Various embodiments of systems and methods for implantable electrode recording of an alternating electric field are disclosed herein. In particular, the system enables interradial distance-based recording of electric field differential resultant from an applied waveform between various locations within an organic structure. The determination of electric field differential between measuring contacts can enable a practitioner to create a mapping of electric field differential throughout an organic structure that can aid in understanding of how structural and material variability throughout the bodily structure affects electric field propagation through the structure.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
55.
SYSTEMS AND METHODS FOR A STEREOTACTIC COORDINATE ADJUSTER
Various embodiments of a stereotactic coordinate adjuster system and associated method for positional adjustment of components of a stereotactic system are disclosed herein. The system provides fine adjustment to the stereotactic system by providing form-fitting components that encapsulate components of the stereotactic system and allow for fine positional adjustment of an arc support member and a slide portion of the stereotactic system.
A61B 90/10 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre
56.
SYSTEMS AND METHODS FOR NON-INTRUSIVE DECEPTION DETECTION
Arizona Board of Regents on behalf of Arizona State University (USA)
Inventeur(s)
Macknik, Stephen L.
Martinez-Conde, Susana
Dale, Richard E.
Besserman, Richard
Mcdaniel, Troy Lee
Abrégé
Systems and methods for detecting deceptive intent of a subject include observing eye movements of the subject and correlating the observed movements to known baseline neurophysiological indicators of deception. A detection system may record eye movement data from the subject, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not the subject is lying. The detection system may create an alert if deception is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device, such as a non-invasive, non-contact device attached to the subject's computing device and configured to non-obtrusively record the eye movement data.
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
Various exemplary embodiments relate to an anonymous database system. The system includes a plurality of biometric nodes in communication with one another. Each of the plurality of biometric nodes includes a biometric input that receives biometric data from a user. The system also includes at least one central database in communication with the plurality of biometric nodes; and a plurality of institution databases in communication with the plurality of biometric nodes. A first node of the plurality of biometric nodes is configured to receive a message from a second node of the plurality of biometric nodes, the message requesting authorization of data access by the second node. Various embodiments relate to a method for performing an action requiring multiple levels of authentication using an anonymous database system.
A system provides a computer-implemented rendered visualization of a surgeon's path or “roadmap” to a particular target region during a surgical case are disclosed herein. The system includes an approach library in communication with an operating microscope that includes data related to various surgical approach sequences, or “roadmaps” to various target regions. The approach library can be populated by the system and analyzed for variance and trends, as well as provide direct or indirect instruction and guidance through a display member during a surgical case.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/20 - Microscopes chirurgicaux caractérisés par des aspects non optiques
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
59.
METHOD OF ENGINEERING AND ISOLATING ADENO-ASSOCIATED VIRUS
Engineered adeno-associated virus (AAV) capsid proteins, each having tropism to a desired target cell or tissue type, are disclosed. Also disclosed are methods of generating the engineered proteins, libraries comprising the engineered proteins, recombinant viruses comprising the engineered proteins, and nucleic acid constructs encoding the engineered proteins.
A system provides an electrosurgical tool that delivers an electrosurgical waveform that can be optimized for electrosurgical tasks such as cutting and cauterization of various tissues. The electrosurgical waveform can include a first electrosurgical waveform and a second electrosurgical waveform for simultaneous delivery at respective stimulating electrodes of a stimulating pathway. In some examples, the second electrosurgical waveform is phase-shifted by 180-degrees to minimize deep penetration of current through tissue. The electrosurgical tool provides a relief pathway for further minimization of deep penetration of current through tissue, and can also enable adaptive adjustment of an impedance of the relief pathway, the stimulating pathway, and/or adjustment of one or more parameters of the electrosurgical waveform.
A61B 18/04 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage
A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Systems and methods for detecting a traumatic brain injury (TBI). The system comprises a sensing arrangement and a control unit. The sensing arrangement collects eye movement data of a user. The control unit is in communication with the sensing arrangement and configured to compare the eye movement data to one or more baseline measurements of eye movement dynamics. The control unit is also configured to generate an alert indicating the presence or severity of the TBI for delivery to control unit administrator if the eye movement data diverges from one or more of the baseline measurements by a threshold amount.
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
62.
Systems and methods for microvascular anastomotic coupler ring delivery device
Various embodiments of a device for deep surgical corridor microvascular anastomosis are described herein. A device, comprising: an elongated body; a rod disposed at least partially within the channel of the elongated body; an actuator in association with the elongated body and the rod, wherein the actuator is operable to actuate the rod in a first axial direction; and a pair of coupling arms in association with the distal portion of the rod, wherein the actuator is operable to actuate the rod in a first axial direction such that the pivotable end of each coupling arm of the pair of coupling arms is consequently actuated in the first axial direction such that the pair of coupling arms are parallel with one another in a closed configuration.
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour réaliser l'anastomoseBoutons pour anastomose
63.
SYSTEMS AND METHODS FOR AN AIRWAY ISOLATION DRAPE APPARATUS
Various embodiments for an airway isolation apparatus having a wire frame that is operable for deploying an isolation drape over a subjects head to protect healthcare and other workers from contagious or otherwise harmful agents are disclosed herein. The drape frame may include a frame base. A frame channel may extend from the frame base and a frame wire may extend through the frame channel A frame opening may be defined by the frame base and the frame channel of the drape frame. A drape may be disposed in the frame opening. Accordingly, the drape frame may be deployed in place over the chest and head of a subject. The drape may cover the subjects head to isolate the mouth and nose of the subject preparatory to accessing these airways for intubation or other procedure.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Dignity Health (USA)
Inventeur(s)
Vignola, Claudio
Nethken, Cherrylynne
Palmiscno, Kristin
Mcdaniel, Troy
Joshi, Nikita
Rajeev, Athul
Abrégé
Described herein is an assistive medical system that is designed for individuals who are impacted by Midline-Shift Syndrome. Its purpose is to help them reorient and maintain their midline position to improve posture, balance, and other cognitive functions. This is achieved through haptic-feedback mechanisms and visual cues that gently notify the user when their position has deviated from the midline orientation.
An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
F21S 2/00 - Systèmes de dispositifs d'éclairage non prévus dans les groupes principaux ou , p. ex. à construction modulaire
A toothbrush system configured to be coupled to an external suction source. The toothbrush system includes a shaft with a main body with a first end and a second end, and a bristle array and a suction port arranged at the second end. The bristle array and the suction port both extend away from the shaft so that an opening of the suction port is proximal to a distal end of the bristle array. The shaft also includes a stem arranged at the first end. The stem includes a passageway that extends through the main body to provide a fluid connection to the suction port, and is configured to be coupled to the external suction source. Also, the handle is removably coupled to the shaft and includes a drive system operably coupled to the bristle array to actuate motion of the bristle array.
Various embodiments of a system and associated method for whole-blade acquisition and phase correction for fast and robust MR imaging are disclosed herein. In particular, the system enables sampling of odd and even k-space echoes in the same k-space as well as a whole-blade phase correction strategy to achieve improved image quality at an accelerated imaging rate.
G01R 33/561 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne par réduction du temps de balayage, c.-à-d. systèmes d'acquisition rapide, p. ex. utilisant des séquences d'impulsions écho-planar
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
68.
Systems and methods for volumetric measurement of maximal allowable working volume within a surgical corridor
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventeur(s)
Houlihan, Lena Mary
Naughton, David
Preul, Mark C.
Abrégé
Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
G06T 11/20 - Traçage à partir d'éléments de base, p. ex. de lignes ou de cercles
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
69.
SYSTEMS AND METHODS FOR A HYDROPHILIC CATHETER INTRODUCTION SYSTEM
Various embodiments of a hydrophilic catheter introduction system for improved insertion of a shunt catheter are disclosed herein. The catheter introduction system includes an introducer sheath defining an inner surface that includes a hydrophilic coating to aid in passage of a catheter through the introducer sheath. Evaluation of the catheter introduction system with respect to other catheter introduction systems resulted in a significant decrease in average catheter threading time.
Various embodiments of an expandable interbody cage device configured to reduce subsidence into an endplate of a vertebral body by including a plurality of arms that engage the cortical tissue of the vertebral body. The plurality of arms increase the surface area and improve distribution of force, especially around stronger parts of the endplate such as the cortical bone at the rim of the endplate. The expandable interbody cage device maintains a low or slim profile while in a “closed” configuration during insertion between vertebrae and is further operable to laterally expand into an “open” configuration that increases the surface area of the expandable interbody cage device after insertion to securely engage the expandable interbody cage device between the vertebra. The expandable interbody cage device further includes one or more ports and/or cavities in which bone graft material can be disposed within.
Methods of externally reinforcing biological vessels include forming a reinforcing frame around a vessel using a pliable framing material, and applying a solidifying substance to the framing material that transitions the framing material and solidifying substance to a solid state, forming a solid encasement. The framing material can include a plurality of sheets for application in an overlapping piecemeal fashion to a vessel within a surgical corridor. The solidifying substance permeates the reinforcing frame prior to transitioning to the solid state to ensure that the resulting encasement is filly solidified.
A61F 2/945 - Stents conservant leur forme, c.-à-d. non déformables, après mise en place à l’endroit voulu durcissables, p. ex. stents formés in situ
A61F 2/90 - Stents ayant une forme caractérisée par des éléments filiformesStents ayant une forme caractérisée par une structure de type filet ou de type à mailles caractérisés par une structure de type filet ou de type à mailles
In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy (CLE) are provided. In some embodiments, a method comprises: receiving images captured by a CLE device during brain surgery; providing the images to a convolution neural network (CNN) trained using at least a plurality of images of brain tissue captured by a CLE device and labeled diagnostic or non-diagnostic; receiving an indication, from the CNN, likelihoods that the images are diagnostic images; determining, based on the likelihoods, which of the images are diagnostic images; and in response to determining that an image is a diagnostic image, causing the image to be presented during the brain surgery.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
An implantable valve device includes a valve unit having a flow limiter in operative association with a dial for controlling a flow of material through a lumen in communication with the valve unit. The dial includes a dial indicator viewable through cross-sectional imaging for determining and/or otherwise verifying a "pressure setting" of the valve unit. The valve unit can include a housing that encapsulates the dial therein and provides one or more reference indicators that enable a practitioner to determine an orientation of the valve unit and further clarify the position of the dial indicator. The valve unit can be interrogated through conventional non-invasive cross-sectional imaging methods such as ultrasound.
G06Q 10/1093 - Ordonnancement basé sur un agenda pour des personnes ou des groupes
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
75.
SYSTEMS AND METHODS FOR TREATING LEVODOPA DYSKINESIA, ENHANCING MOTOR BENEFIT, AND DELAYING DISEASE PROGRESSION
Board of Trustees of Michigan State University (USA)
Inventeur(s)
Manfredsson, Fredric
Steece-Collier, Kathy
Abrégé
Disclosed are systems and compositions for reducing the expression of a CaV1.3 protein in a subject and methods of using the systems for treating dyskinesias induced by DA agonist therapy including levodopa-induced dyskinesias (LID), improving the response to levodopa, and improving the response to levodopa in a subject in need thereof; and slowing progression of Parkinson's disease by providing protection against death or dysfunction of substantia nigra dopamine neurons.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 5/18 - Dispositifs pour l'exécution des tests de capacité pour conducteurs de véhicules
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical devices, namely, minimally invasive neurovascular devices, spine technologies being medical apparatus for spinal cord stimulation, spine devices being medical apparatus for spinal cord stimulation and related paraphernalia in the nature of spinal syringes, medical apparatus for spinal disc repair, spiral cross connectors, spinal implants composed of artificial materials for medical conditions that may benefit from a neurological or spinal treatment Educational services, namely, classes, seminars and workshops in the field of neurosciences and delivery of treatments Research services in the field of neuroscience Healthcare services; Healthcare services and particularly clinical health services being healthcare services related to the neurosciences
79.
Systems and methods for treatment of cancer using alternating electric field generation
Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
Disclosed herein are methods for treating hot flushes in a subject. In one embodiment, treating hot flushes includes administering to a subject in need of such treatment, a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for amelioration, alleviation, or prevention of the thermal discomfort in hot flushes, comprising: selecting a subject in need of treatment for hot flushes, administering to the subject a therapeutically effective amount of a TRP channel blocker, such as a TRPV1 blocker, or a pharmaceutically acceptable salt thereof.
A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
81.
METHOD AND APPARATUS FOR A SUCTION CONNECTION SYSTEM
A catheter placement system for drawing a medical tube through a sheath includes a suction generation device and further includes one or more suction adapter devices that enable connection of the suction generation device to the sheath and facilitate insertion of the medical tube into the sheath. The one or more suction adapter devices are operable for lateral removal from the sheath and the medical tube, enabling connection of the medical tube to one or more external devices prior to drawing the medical tube through the sheath.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
82.
Systems and methods for a stereotactic coordinate adjuster
Various embodiments of a stereotactic coordinate adjuster system and associated method for positional adjustment of components of a stereotactic system are disclosed herein. The system provides fine adjustment to the stereotactic system by providing form-fitting components that encapsulate components of the stereotactic system and allow for fine positional adjustment of an arc support member and a slide portion of the stereotactic system.
A61B 90/10 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre
83.
COMPUTER-IMPLEMENTED SYSTEMS AND METHODS FOR COMPUTING PROVIDER ATTRIBUTION
Various embodiments of a computer-implemented system for generating an algorithm configured to compute an attribution output to enhance provider attribution are disclosed.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
Various embodiments of an anatomical model suitable for microsurgical training are disclosed. The anatomical model includes predetermined ergonomic features that accommodate training of a surgical task.
Compounds and berberine compositions containing such compounds that are useful for reducing nicotine dependency. Methods for administering the berberine compositions are also disclosed. The compounds may have a structure according to Formula (I). In Formula (I) R1, R2, R3, R4, and R5 are independently H or D; R6 and R7 are independently hydrogen, deuterium, halogen, C4 to C8 unsubstituted aryl, C4 to C8 substituted aryl, C2 to C6 unsubstituted heterocycle, C2 to C6 substituted heterocycle, C1 to C6 unsubstituted alkyl, C1 to C6 substituted alkyl, C3-C10 unsubstituted cycloalkyl, C3-C10 substituted cycloalkyl, or R6 and R7 are taken together as ═O or ═S; and R8 and R9 are independently selected from a group consisting of methyl, CHF2, and CF3.
C07D 455/03 - Composés hétérocycliques contenant des systèmes cycliques quinolizine, p. ex. alcaloïdes de l'émétine, protoberbérineDérivés alkylènedioxy des dibenzo [a, g] quinolizines, p. ex. berbérine contenant des systèmes cycliques quinolizine directement condensés avec au moins un carbocycle à six chaînons, p. ex. protoberbérineDérivés alkylènedioxy des dibenzo [a, g] quinolizines, p. ex. berbérine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 25/34 - Médicaments pour le traitement des troubles du système nerveux des états d'abus ou de dépendance au tabac
86.
SYSTEMS AND METHODS FOR A CATHETER STABILIZATION AND OCCLUDER APPARATUS
Various embodiments of a catheter stabilizer that includes a retention body and an occluder for positioning within a burr hole or other channel in the body for occlusion and stabilization of a catheter during a surgical procedure are described herein.
Various embodiments of a system and associated method for a surgical positioning apparatus for supporting a patient in supine, lateral, kidney and prone position are disclosed herein.
Disclosed herein is a wheel shield apparatus that includes a pair of elongated parallel tube members in perpendicular engagement with a pair of short parallel tube members, at least one removable side of the wheel shield apparatus is operable to be temporarily opened or removed such that the wheel shield apparatus may be placed around a wheel of a neurosurgical microscope or some other type of heavy wheeled machinery and the removable side may be placed in a closed position such that the wheel shield surrounds the wheel. Each of the pair of elongated parallel tube members and/or each of the pair of short parallel tube members comprises a cavity configured to receive a ballast material to provide sufficient weight to ensure that the wheel shield apparatus contacts the floor such that cables along the floor are pushed out of the way by the wheel shield apparatus and prevented from being run over while the machinery is being transported.
A system for inserting a medical tube within the body using a tunneler device enables formation of a tunnel within the body and further enables concurrent insertion of the medical tube within the body as the tunnel is formed, eliminating extra steps required by current technologies for insertion of the medical tube within the body. The tunneler device provides an attachment element that captures the medical tube and further provides a handle slidably mounted along the tunneler device to aid practitioners when inserting the tunneler device into the body. The tunneler device further provides a bend angle to aid practitioners in forming the tunnel past the clavicle of the body. The tunneler device enables practitioners to place medical tubes within the body while reducing time and friction commonly associated with medical tube placement procedures.
Arizona Board of Regents on Behalf of Arizona State University (USA)
Inventeur(s)
Macknik, Stephen L.
Martinez-Conde, Susana
Dale, Richard E.
Besserman, Richard
Mcdaniel, Troy Lee
Abrégé
Systems and methods for detecting onset, presence, and progression of particular states, including intoxication, include observing eye movements of a subject and correlating the observed movements to known baseline neurophysiological indicators of intoxication. A detection system may record eye movement data from a user, compare the eye movement data to a data model comprising threshold eye movement data samples, and from the comparison make a determination whether or not intoxication or impairment is present. The detection system may alert the user to take corrective action if onset or presence of a dangerous condition is detected. The eye movements detected include saccadic and intersaccadic parameters such as intersaccadic drift velocity. Measurements may be collected in situ with a field testing device. An interactive application may be provided on a user device to provoke the desired eye movements during recording.
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 5/18 - Dispositifs pour l'exécution des tests de capacité pour conducteurs de véhicules
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
91.
DEVICES AND METHODS FOR APPLYING STIMULATION IN THE ASSESSMENT OF CONSCIOUSNESS
A device applies standardized central and peripheral stimuli to a patient for assessment of consciousness. The device is hand-held and includes a first stimulus element for application of peripheral stimuli to a digit (e.g., a finger or a toe) of the patient and a second stimulus element for application of central stimuli to the patient, enabling practitioners to rapidly switch between peripheral and central stimulus application. The device can generate a standardized electrical stimulus, thermal stimulus, and/or mechanical stimulus for application for improved accuracy when assessing consciousness of the patient by methods such as the Glasgow Coma Scale. In another aspect, the device applies standardized stimuli at an appropriate intensity to elicit a response without causing tissue damage.
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (USA)
VAN ANDEL RESEARCH INSTITUTE (USA)
Inventeur(s)
Manfredsson, Fredric
Brundin, Lena
Abrégé
Compositions for increasing the expression of ACMSD in a target cell and methods of using the compositions to provide a general protective effect in a cell or tissue in a subject, or protect a subject from or treating a disease condition associated with inflammation, oxidative stress, protein aggregation, energy failure, toxic exposure such as exposure to pollutants, or any combination thereof.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A spinal implant is disclosed for engagement to portions of a spinal segment after a laminectomy procedure. The spinal implant includes a first member and a second member in orthogonal relation relative to the first member such that the spinal implant generally defines a t-shape configuration. The spinal implant is formed using biocompatible materials to safely adapt to the surgical area. The spinal implant may include hooks or apertures for engaging with portions of bodily tissue. The spinal implant may be engaged to other spinal implants along the spine using one or more arms of an interconnecting arrangement.
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
A61F 2/44 - Articulations pour l'épine dorsale, p. ex. vertèbres, disques intervertébraux
Disclosed herein is a system/apparatus for storing, use in therapy, and transporting a (bionic) exoskeleton. The apparatus includes a frame comprising a plurality of legs, a seat, and a back which are operable for being moved between one or more configurations. The seat of the frame defines a seat surface configured for engagement with an exoskeleton. Furthermore, the back of the frame is operably engaged with the seat such that the back of the frame may be folded over, into, or extended from the frame to reduce an overall profile size of the apparatus in a collapsed or folded configuration. The apparatus may further include a pair of footrests defined along the legs that rotate in a lateral direction relative to the frame for the patients ease of transition into the exoskeleton. The frame also includes a locking mechanism that aids to from a storage configuration or a ready configuration.
A multidimensional tracking system incorporates observed positions of objects tracked within various virtual spaces recorded by a plurality of hierarchical tracking systems based on observable positional relationships between the plurality of hierarchical tracking systems. In one embodiment, the multidimensional tracking system displays and records tracking and manipulation of physical objects over time relative to a virtual space. Further, the multidimensional tracking system can evaluate the accuracy of observed positions of objects as well as mappings that translate each virtual space to one another based on observable positional relationships between tracked objects.
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
DIGNITY HEALTH (USA)
Inventeur(s)
Barton, Jennifer Kehlet
Thawani, Nitika
Gelb, Danielle Ann
Cohen, Audrey Tamra
Olivas, Hiram
Mapp, Jacob Emanuel
Zenhausern, Ryan Stephen
Vargas Lopez, Jesus Daniel
Abrégé
A system includes a device associated with an endoscopy guided procedure including a housing defining a housing channel with at least a portion of the housing configured for deployment within a cavity. The device further includes a plurality of bodies defining respective channels defined within the housing. The housing defines a longitudinal axis, and the plurality of channels extends throughout the housing around the longitudinal axis. Each of the plurality of channels accommodates selective activation of radiation emittance from a predetermined different position along the housing via one or more radiation elements such that the plurality of channels collectively provides a predetermined spatial distribution of a radiation treatment to a target area along the cavity.
A modular electrode system for therapeutic application of an electric field to a tissue is described. The modular electrode system includes a flexible scaffold that conforms to a variable convex or concave surface such as a resected tissue cavity or other target tissue area and includes one or more surface electrodes in addition to one or more depth electrodes. The modular electrode system includes a control system that communicates with the plurality of electrodes of the flexible scaffold to deliver a stimulating voltage and receive measured voltage values for real-time optimization of the electric field generated within the tissue.
Electric field therapy requires the strategic delivery of electrical energy to living tissue. Machine learning in the context of a computer-implemented planning environment can be adopted to enhance planning, monitoring, and modulation of this therapy.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
99.
SYSTEMS AND METHODS FOR IMPLANTABLE ELECTRODES WITH FEEDBACK FOR APPLICATION OF ELECTRIC FIELD THERAPY WITHIN THE BODY
An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.
A61N 1/18 - Application de courants électriques par électrodes de contact
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A method for bending a surgical rod using an automated bending system includes receiving an indication of a plurality of line segments defined on the rod and an indication of an angle measurement to be formed between at least two adjacent ones of the plurality of line segments. Bending parameters to perform on the rod to form the angle measurement between the at least two adjacent ones of the plurality of line segments are determined and operation of the automated bending system is controlled using the bending parameters to create an angle having the angle measurement between the at least two adjacent ones of the plurality of line segments.
A61B 17/88 - Moyens ou procédés pour implanter ou pour extraire des dispositifs de fixation interne
A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
B21D 7/08 - Cintrage des barres, profilés ou tubes par passage entre des rouleaux ou à travers une matrice courbe
B21D 7/12 - Cintrage des barres, profilés ou tubes avec une commande à programme
B21D 7/14 - Cintrage des barres, profilés ou tubes combiné avec une mesure des courbures ou des longueurs
B21D 43/00 - Dispositifs d'alimentation, de positionnement ou de stockage combinés à des appareils pour travailler ou traiter les tôles, les tubes ou les profilés, disposés dans ces appareils ou spécialement adaptés pour être utilisés en association avec ces appareilsAssociation de dispositifs de coupe avec ces appareils
B21F 1/00 - Cintrage des fils métalliques autre que l'enroulementRedressage des fils métalliques
B21F 45/00 - Travail du fil métallique pour la fabrication d'autres objets particuliers
