Abstract

Proteins comprising a C3 and/or C3b binding polypeptide and a VEGF inhibitor, and their use in treating complement-mediated disorders, are described.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors

Abstract

The invention relates to proteins having multi-specific binding abilities by fusion of an OB-fold variant, in particular from the Sac7d family, to the light or heavy chain of an antibody.

IPC Classes  ?

• C07K 14/54 - Interleukins [IL]
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the complement component 3 (C3) and/or the component C3b obtained after hydrolysis of C3, and inhibits the complement cascade.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/605 - Glucagons
• C07K 14/765 - Serum albumin, e.g. HSA

Abstract

The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the human leptin receptor and is able to trigger the crossing of the intestinal barrier, in particular of biologicals associated with it.

IPC Classes  ?

• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

The invention relates to variants of OB-fold proteins, hi particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 35/00 - Antineoplastic agents

Abstract

Proteins comprising a C3 and/or C3b binding polypeptide and a VEGF inhibitor, and their use in treating complement-mediated disorders, are described.

IPC Classes  ?

• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• A61P 37/02 - Immunomodulators
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 38/00 - Medicinal preparations containing peptides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the complement component 3 (C3) and/or the component C3b obtained after hydrolysis of C3, and inhibits the complement cascade.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/765 - Serum albumin, e.g. HSA
• C07K 19/00 - Hybrid peptides
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that are able to bind a subunit of a multimeric protein and inhibit the formation of the multimer.

IPC Classes  ?

• C07K 14/44 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from protozoa
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The invention relates to proteins having multi-specific binding abilities by fusion of an OB-fold variant, in particular from the Sac7d family, to the light or heavy chain of an antibody.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/54 - Interleukins [IL]
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

Chemical products for use in industry and science; chemical reagents (other than for medical or veterinary use); chemical diagnostic reagents for industrial use; chemical substances intended for separation (other than for medical or veterinary purposes). Pharmaceutical products and substances; medical products and substances; veterinary preparations and substances; biological preparations for pharmaceutical use; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in chromatography (medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus for non-medical use; scientific apparatus and instruments for therapeutic, diagnostic and analytical use purposes, namely protein chips or DNA chips; scientific apparatus, namely, protein synthesis apparatus, purification of proteins and biomolecules, protein deposition, imaging for identification of molecular interactions; biosensors and sensors (measuring apparatus and instruments). Research and development of new products regarding science and medicine; laboratory services, namely diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory.

Abstract

The invention relates to a topical composition containing a variant of an OB-fold protein, and also to the process for preparing the same.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61K 9/08 - Solutions

Goods & Services

Chemical products for use in industry and science; chemical reagents (other than for medical or veterinary use); chemical diagnostic reagents for industrial use; chemical substances intended for separation (other than for medical or veterinary purposes). Pharmaceutical products and substances; medical products and substances; veterinary preparations and substances; biological preparations for pharmaceutical use; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in chromatography (medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus for non-medical use; scientific apparatus and instruments for therapeutic, diagnostic and analytical use purposes, namely protein chips or DNA chips; scientific apparatus, namely, protein synthesis apparatus, purification of proteins and biomolecules, protein deposition, imaging for identification of molecular interactions; biosensors and sensors (measuring apparatus and instruments). Medical apparatus and instruments; screening apparatus and instruments for medical use; separation apparatus and instruments for medical use; chromatography apparatus and instruments for medical use. Research and development of new products regarding science and medicine; laboratory services, namely medical, pharmaceutical and biological research and diagnostic services provided by a laboratory.

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that are able to bind a subunit of a multimeric protein and inhibit the formation of the multimer.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Goods & Services

Chemical products for use in industry and science; chemical reagents (except for medical and veterinary use); chemical diagnostic reagents for industrial use; chemical substances intended for separation (other than for medical or veterinary purposes); chemical substances, chemical materials and chemical products, and natural elements; chemical products for the purification of proteins for in-vitro use; media for chromatography other than for medical use; chromatography media for scientific laboratories; substances for laboratory use; laboratory reagents for scientific use; diagnostic reagents for scientific use or for research; proteins for scientific purposes; chemical products for use in scientific diagnosis; laboratory chemicals for scientific use; biochemical products for in-vitro and in-vivo scientific use; proteins for use in industry; chemical products for use in chromatography, other than for medical or veterinary use. Biochemical preparations for medical use; biochemical preparations for veterinary use; biological preparations for veterinary use; biological preparations for medical use; chemical preparations for medical use; chemical preparations for veterinary use; medical preparations; reagents for medical use; pharmaceutical preparations and substances; biological reagents for medical use; biological reagents for veterinary use; reagents and substances for medical and veterinary diagnostic purposes; diagnostic reagents for medical use; chemical reagents for medical or veterinary use. Diagnostic apparatus for non-medical use; testing apparatus not for medical use; scientific apparatus and instruments; chromatography apparatus for laboratory or scientific use; separation apparatus for laboratories; laboratory apparatus and instruments; chromatography columns for laboratory use; separation columns for scientific purposes. Medical apparatus and instruments; instruments for medical use; separation instruments for medical use; chromatography instruments for medical use; chromatography columns for medical use; affinity chromatography columns for medical use. Chromatography columns for industrial use; chemical treatment equipment; chromatography apparatus for industrial use. Medical and pharmacological research services; scientific laboratory services; biological laboratory services; research and development in the field of biotechnology; research and development for the pharmaceutical industry; research and development of new products; scientific research and development.

Goods & Services

Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Research and development of new products regarding science and medicine; laboratory services, namely, diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory

Goods & Services

Chemical reagents, other than for medical and veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes; chemical substances for analyses in laboratories, other than for medical or veterinary purposes; chemical products for the purification of proteins for in-vitro use; media for chromatography other than for medical use, namely, for separation of a mixture into components; chromatography media for scientific laboratories, namely, for separation of a mixture into components; diagnostic laboratory reagents for scientific use; diagnostic reagents for scientific use or for research; proteins in raw material form for scientific research purposes; chemical products for use in scientific diagnosis, not for medical or veterinary purposes; biochemical products for in-vitro and in-vivo scientific use; proteins for use in industry; chemical products for use in chromatography, other than for medical or veterinary use Biochemical preparations for medical use, namely, for the detection and the diagnosis of cancers, inflammation, neurologic disorders, immune system related diseases and disorders; diagnostic preparations for medical purposes; reagents for medical use; biological reagents for medical use; reagents and substances for medical and veterinary diagnostic purposes; diagnostic reagents for medical use; chemical reagents for medical or veterinary use Diagnostic apparatus for the detection of pathogens, allergens and contaminants for laboratory or research use and not for medical use; testing apparatus not for medical use, namely, electronic analyzers for testing chemical and biological substances for the presence, absence, or quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for measuring relative DNA, RNA and proteins and parts and fittings therefor; chromatography apparatus for laboratory or scientific use; separation apparatus for laboratories, namely, pre-packed columns, laboratory filters and hollow fiber membranes for use in separation; chromatography columns for laboratory use; separation columns for scientific purposes Separation instruments, namely, gas chromatography apparatus for medical use; chromatography instruments for medical use; chromatography columns for medical use; affinity chromatography columns for medical use Chromatography columns for industrial use; chromatography apparatus for industrial use Medical and pharmacological research services; scientific laboratory services; biological laboratory services; research and development in the field of biotechnology; research and development for the pharmaceutical industry; research and development of new products; scientific research and development

Goods & Services

Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Research and development of new scientific and medical products; laboratory services, namely, diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory

Goods & Services

Chemical products for use in industry and science; chemical reagents (except for medical and veterinary use); chemical diagnostic reagents for industrial use; chemical substances intended for separation (other than for medical or veterinary purposes). Pharmaceutical products and substances; medical products and substances; veterinary preparations and substances; biological preparations for pharmaceutical use; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in chromatography (medical, surgical, dental and veterinary). Diagnostic apparatus for non-medical use; testing apparatus for non-medical use; scientific apparatus and instruments for therapeutic, diagnostic and analytical use purposes, namely protein chips or DNA chips; scientific apparatus, namely, protein synthesis apparatus, purification of proteins and biomolecules, protein deposition, imaging for identification of molecular interactions; biosensors and sensors (measuring apparatus and instruments). Research and development of new scientific and medical products; laboratory services, namely diagnostic and research services with respect to medicine, pharmaceuticals and biotechnology provided by a laboratory.

Goods & Services

Chemical reagents other than for medical or veterinary use; chemical diagnostic reagents for industrial use; chemical substances intended for separation of proteins other than for medical or veterinary purposes Pharmaceutical products and substances for the treatment of cancers, inflammation, neurologic disorders and immune system related diseases and disorders; diagnostic preparations and substances for veterinary purposes; biological preparations for pharmaceutical use, namely, biological preparations for the treatment of cancers, inflammation, neurologic disorders, and immune system related diseases and disorders; reagents for medical, surgical, veterinary and dental use; diagnostic reagents for medical, surgical, veterinary and dental use; chemical products intended for use in medical, surgical, dental and veterinary chromatography Diagnostic apparatus for non-medical use, namely, diagnostic apparatus for testing food; testing apparatus for non-medical use, namely, electronic and optical analyzers for testing chemical and biological substances for the presence, absence and quantity of target chemicals, biologics and contaminants; scientific apparatus and instruments for diagnostic and analytical use purposes, namely, protein chips and DNA chips; scientific apparatus for use in protein purification; measuring apparatus and instruments, namely, electronic portable analyzers for detecting biological agents Medical apparatus and instruments for use in surgery and medical imaging; medical apparatus and instruments for cardiac screening, cancer screening and infection screening; blood component separation apparatus and instruments for medical use; chromatography apparatus and instruments for medical use Research and development of new products regarding science and medicine; laboratory services, namely, medical, pharmaceutical and biological research and diagnostic services provided by a laboratory

Goods & Services

Chemicals for use in industry and science; Chemical reagents, other than for medical or veterinary purposes; Chemical diagnostic reagents for industrial use; Chemical substances for use in separation [other than medical or veterinary use]; Chemical substances, chemical materials and chemical preparations, and natural elements; Chemicals for use in the purification of proteins for in vitro use; Media for use in chromatography [not medical]; Chromatographic supports for scientific laboratory use; Substances for laboratory use; Laboratory reagents for scientific use; Diagnostic reagents for scientific or research use; Proteins for use in science; Chemical products for diagnostic use [scientific]; Laboratory chemicals for scientific use; Biochemicals for in vitro and in vivo scientific use; Proteins for use in industry; Chemicals for use in chromatography [other than medical and veterinary]. Biochemical preparations for medical use; Biochemical preparations for veterinary use; Biological preparations for veterinary purposes; Biological preparations for medical purposes; Chemical preparations for medical purposes; Chemical preparations for veterinary purposes; Medical preparations; Reagents for medical use; Pharmaceutical preparations and substances; Biological reagents for medical use; Biological reagents for veterinary use; Reagents and media for medical and veterinary diagnostic purposes; Diagnostic reagents for medical use; Chemical reagents for medical or veterinary purposes. Diagnostic apparatus, not for medical purposes; Testing apparatus not for medical purposes; Scientific apparatus and instruments; Chromatographs for scientific or laboratory use; Separating apparatus for laboratory use; Laboratory apparatus and instruments; Chromatography columns; Separation columns for scientific purposes. Medical apparatus and instruments; Medical instruments; Separation instruments for medical use; Chromatographic instruments for medical use; Chromatographic columns for medical use; Columns for affinity chromatography [for medical use]. Chromatography columns for industrial use; Chemical processing equipment; Chromatography apparatus for industrial purposes. Medical and pharmacological research services; Scientific laboratory services; Biological laboratory services; Research and development in the field of biotechnology; Research and development for the pharmaceutical industry; Research and development of new products; Scientific research and development.

Abstract

The invention relates to proteins having multi-specific binding abilities byfusion of an OB-fold variant, in particular from the Sac7d family,to the light or heavy chain of an antibody.

IPC Classes  ?

• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Abstract

The invention relates to an oral administration composition containing an OB-fold protein variant, and to the method for preparing the same.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to a topical composition containing a variant of an OB-fold protein, and also to the process for preparing the same.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates to an oral administration composition containing an OB-fold protein variant, and to the method for preparing the same.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 49/00 - Preparations for testing in vivo
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

The invention relates to a topical composition containing a variant of an OB-fold protein, and also to the process for preparing same.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• A61P 17/00 - Drugs for dermatological disorders
• A61P 27/02 - Ophthalmic agents

Goods & Services

Chemicals used in industry and science; chemical reagents (other than for medical or veterinary purposes); chemical diagnostic reagents for industrial use; chemical substances for use in separation (other than for medical or veterinary purposes). Pharmaceutical preparations and substances; medical substances and preparations; veterinary substances and preparations; Biological preparations for pharmaceutical purposes; reagents for medical, surgical, veterinary and dental purposes; diagnostic reagents for medical, surgical, veterinary and dental purposes; chemicals for use in chromatography (medical, surgical, dental and veterinary). Diagnostic apparatus, not for medical purposes; testing apparatus, not for medical purposes; scientific apparatus and instruments for therapeutic, diagnostic and analytical purposes, namely protein chips or DNA chips; scientific apparatus, namely apparatus for synthesising proteins, purifying proteins and biomolecules, depositing proteins, imaging for identifying molecular interactions; sensors and biosensors (apparatus and measuring instruments). Scientific and medical research and development; laboratory work, namely medical, pharmaceutical and biotechnological research and diagnosis carried out by a laboratory.

Abstract

The invention relates to an oral administration composition containing an OB-fold protein variant, and to the method for preparing the same.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 49/00 - Preparations for testing in vivo
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

The invention relates to proteins having multi-specific binding abilities byfusion of an OB-fold variant, in particular from the Sac7d family,to the light or heavy chain of an antibody.

IPC Classes  ?

• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind PD-L1 or HSP110 and are able to be used alone or in combination for cancer treatment.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/765 - Serum albumin, e.g. HSA
• C07K 19/00 - Hybrid peptides

Abstract

The invention relates to a polypeptide comprising a variant of a protein of the Sac7d family that specifically binds to the human leptin receptor and is able to trigger the crossing of the intestinal barrier, in particular of biologicals associated with it.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria